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https://www.readbyqxmd.com/read/29332451/psca-rs1045531-polymorphism-and-the-risk-of-prostate-cancer-in-a-chinese-population-undergoing-prostate-biopsy
#1
Xuefeng Zhang, Qin Hu, Ye Chen, Miao Li, Huming Yin, Chenchao Zhou, Gang Li, Jianquan Hou
BACKGROUND AND PURPOSE: This study explored the association between a single-nucleotide polymorphism of prostate stem cell antigen and prostate cancer in Chinese patients undergoing prostate biopsy. MATERIALS AND METHODS: DNA from 416 patients undergoing prostate biopsy was typed for the prostate stem cell antigen rs1045531 single-nucleotide polymorphism. The frequency of the rs1045531 polymorphism in patients with prostate cancer and in patients with benign prostatic hyperplasia was compared...
December 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29319340/denaturing-gradient-gel-electrophoresis-polymerase-chain-reaction-comparison-of-chitosan-effects-on-anaerobic-cultures-of-broiler-cecal-bacteria-and-salmonella-typhimurium
#2
Michael Hume, Muhammad Umar Sohail
Enteropathogen colonization and product contamination are major poultry industry problems. The emergence of antibiotic resistance, and associated risks to human health, is limiting the use of antibiotics as first-line defense against enteropathogens in poultry. The chitin derivative, chitosan, has drawn substantial attention for its bactericidal properties. Different molecular weight (MW) chitosans can have varied effects against different bacteria in monoculture. In the current study, cecal contents from each of three market-age broilers and Salmonella Typhimurium, as indicator enteropathogen, were exposed to in vitro anaerobic culture to three chitosan preparations (0...
January 10, 2018: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/29313671/cluster-formation-in-the-superconducting-complex-intermetallic-compound-be21pt5
#3
Alfred Amon, Alim Ormeci, Matej Bobnar, Lev G Akselrud, Maxim Avdeev, Roman Gumeniuk, Ulrich Burkhardt, Yurii Prots, Christoph Hennig, Andreas Leithe-Jasper, Yuri Grin
Materials with the crystal structure of γ-brass type (Cu5Zn8 type) are typical representatives of intermetallic compounds. From the electronic point of view, they are often interpreted using the valence electron concentration approach of Hume-Rothery, developed previously for transition metals. The γ-brass-type phases of the main-group elements are rather rare. The intermetallic compound Be21Pt5, a new member of this family, was synthesized, and its crystal structure, chemical bonding, and physical properties were characterized...
January 9, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29301558/leucine-and-ace-inhibitors-as-therapies-for-sarcopenia-lace-trial-study-protocol-for-a-randomised-controlled-trial
#4
Margaret M Band, Deepa Sumukadas, Allan D Struthers, Alison Avenell, Peter T Donnan, Paul R Kemp, Karen T Smith, Cheryl L Hume, Adrian Hapca, Miles D Witham
BACKGROUND: Sarcopenia (the age-related loss of muscle mass and function) is a major contributor to loss of mobility, falls, loss of independence, morbidity and mortality in older people. Although resistance training is effective in preventing and reversing sarcopenia, many older people are sedentary and either cannot or do not want to exercise. This trial examines the efficacy of supplementation with the amino acid leucine and/or angiotensin converting enzyme inhibition to potentially improve muscle mass and function in people with sarcopenia...
January 4, 2018: Trials
https://www.readbyqxmd.com/read/29281117/an-update-on-equine-postoperative-ileus-definitions-pathophysiology-and-management
#5
REVIEW
Z M Lisowski, R S Pirie, A T Blikslager, D Lefebvre, D A Hume, N P H Hudson
Postoperative ileus (POI) is a serious condition which any horse undergoing abdominal surgery is at risk of developing, leading to increased hospitalisation time and resulting costs. Advances in the understanding of the development of equine POI are mainly based on human and rodent literature, where manipulation-induced inflammation has been identified as a key trigger, with activation of resident muscularis externa macrophages playing a crucial role in the pathophysiology. Despite many pharmacological trials in all species, there is no single completely successful treatment for POI, highlighting that the condition is multifactorial in cause and requires a multimodal approach to minimise its incidence...
December 27, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29273069/single-walled-carbon-nanotubes-modulate-pulmonary-immune-responses-and-increase-pandemic-influenza-a-virus-titers-in-mice
#6
Hao Chen, Xiao Zheng, Justine Nicholas, Sara T Humes, Julia C Loeb, Sarah E Robinson, Joseph H Bisesi, Dipesh Das, Navid B Saleh, William L Castleman, John A Lednicky, Tara Sabo-Attwood
BACKGROUND: Numerous toxicological studies have focused on injury caused by exposure to single types of nanoparticles, but few have investigated how such exposures impact a host's immune response to pathogen challenge. Few studies have shown that nanoparticles can alter a host's response to pathogens (chiefly bacteria) but there is even less knowledge of the impact of such particles on viral infections. In this study, we performed experiments to investigate if exposure of mice to single-walled carbon nanotubes (SWCNT) alters immune mechanisms and viral titers following subsequent influenza A virus (IAV) infection...
December 22, 2017: Virology Journal
https://www.readbyqxmd.com/read/29241532/glucocorticoid-receptor-binding-induces-rapid-and-prolonged-large-scale-chromatin-decompaction-at-multiple-target-loci
#7
Alasdair W Jubb, Shelagh Boyle, David A Hume, Wendy A Bickmore
Glucocorticoids act by binding to the glucocorticoid receptor (GR), which binds to specific motifs within enhancers of target genes to activate transcription. Previous studies have suggested that GRs can promote interactions between gene promoters and distal elements within target loci. In contrast, we demonstrate here that glucocorticoid addition to mouse bone-marrow-derived macrophages produces very rapid chromatin unfolding detectable by fluorescence in situ hybridization (FISH) at loci associated with GR binding...
December 12, 2017: Cell Reports
https://www.readbyqxmd.com/read/29239119/a-retrospective-review-of-acute-myeloid-leukaemia-in-35-dogs-diagnosed-by-a-combination-of-morphologic-findings-flow-cytometric-immunophenotyping-and-cytochemical-staining-results-2007-2015
#8
L L Davis, K R Hume, T Stokol
Acute myeloid leukaemia (AML) is an uncommon, rapidly progressive neoplasm in dogs. The aim of this retrospective study was to characterize the clinical presentation, haematologic findings, diagnostic imaging results, treatment and survival time of a contemporary cohort of dogs with AML. Diagnosis was based on >20% blasts in bone marrow or blood identified as myeloid based on morphologic findings, flow cytometric immunophenotyping and cytochemical staining. Medical records of 35 dogs diagnosed with AML from 2007 to 2015 were included...
December 14, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/29239110/association-of-prognostic-features-and-treatment-on-survival-time-of-dogs-with-systemic-mastocytosis-a-retrospective-analysis-of-40-dogs
#9
S J Moirano, S F Lima, K R Hume, E M Brodsky
Systemic mastocytosis is a rare phenomenon, with limited information regarding prognostic features and effective treatment of canine patients with this disease. The objective of this study is to determine the impact of certain features and treatments on dogs with systemic mastocytosis. The medical records of 40 dogs from 4 northeastern US veterinary hospitals, with evidence of systemic mast cell disease, were evaluated retrospectively. Variables analysed with relation to overall survival and prognostic significance included treatment protocol used, substage, presence of a cutaneous or visceral tumour, presence of multiple cutaneous Mast cell tumours, grade of the primary tumour and metastatic site(s)...
December 14, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/29230814/nigella-sativa-l-as-an-alternative-antibiotic-feed-supplement-and-effect-on-growth-performance-in-weanling-pigs
#10
Branko T Petrujkić, Ross C Beier, Haiqi He, Kenneth J Genovese, Christina L Swaggerty, Michael E Hume, Tawni L Crippen, Roger B Harvey, Robin C Anderson, David J Nisbet
BACKGROUND: Nigella sativa L. (NS) is a plant containing bioactive constituents like thymoquinone. Extracts of NS improve performance and reduce enteropathogen colonization in poultry and small ruminants but studies with swine are lacking. In two different studies oral administration of NS extracts at doses equivalent to 0, 1.5 and 4.5 g extract kg-1 diet was assessed on piglet performance and intestinal carriage of wildtype Escherichia coli and Campylobacter, and Salmonella Typhimurium...
December 11, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29215000/the-evolution-of-the-macrophage-specific-enhancer-fms-intronic-regulatory-element-within-the-csf1r-locus-of-vertebrates
#11
David A Hume, Evi Wollscheid-Lengeling, Rocio Rojo, Clare Pridans
The Csf1r locus encodes the receptor for macrophage colony-stimulating factor, which controls the proliferation, differentiation and survival of macrophages. The 300 bp Fms intronic regulatory element (FIRE), within the second intron of Csf1r, is necessary and sufficient to direct macrophage-specific transcription. We have analysed the conservation and divergence of the FIRE DNA sequence in vertebrates. FIRE is present in the same location in the Csf1r locus in reptile, avian and mammalian genomes. Nearest neighbor analysis based upon this element alone largely recapitulates phylogenies inferred from much larger genomic sequence datasets...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29212683/-hot-joints-infection-protocol-reduces-unnecessary-post-operative-re-admissions-following-total-hip-and-knee-arthroplasty
#12
J Dattilo, D Gittings, M Sloan, R Charette, E Hume, G-C Lee
AIMS: To evaluate the effectiveness of an institutionally developed algorithm for evaluation and diagnosis of prosthetic joint injection and to determine the impact of this protocol on overall hospital re-admissions.p PATIENTS AND METHODS: We retrospectively evaluated 2685 total hip arthroplasty (THA) and total knee arthroplasty (TKA) patients prior to (1263) and following (1422) the introduction of an infection detection protocol. The protocol used conservative thresholds for C-reactive protein to direct the medical attendant to aspirate the joint...
December 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/29193327/effects-of-toceranib-phosphate-on-the-hypothalamic-pituitary-thyroid-axis-in-tumor-bearing-dogs
#13
K R Hume, V L Rizzo, J R Cawley, C E Balkman
BACKGROUND: Thyroid dysfunction is associated with the use of tyrosine kinase inhibitors (TKI) in people. HYPOTHESIS/OBJECTIVES: To determine whether dysfunction in the hypothalamic-pituitary-thyroid axis occurs in dogs receiving the TKI, toceranib phosphate. ANIMALS: Forty-three client-owned dogs with cancer. METHODS: Prospective, observational study. Concentrations of total thyroxine (TT4), free thyroxine (FT4), total triiodothyronine (TT3), and thyroid-stimulating hormone (TSH) were evaluated on day 0, 30, and 90...
November 30, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29182495/platelet-transfusion-for-patients-with-cancer-american-society-of-clinical-oncology-clinical-practice-guideline-update
#14
Charles A Schiffer, Kari Bohlke, Meghan Delaney, Heather Hume, Anthony J Magdalinski, Jeffrey J McCullough, James L Omel, John M Rainey, Paolo Rebulla, Scott D Rowley, Michael B Troner, Kenneth C Anderson
Purpose To provide evidence-based guidance on the use of platelet transfusion in people with cancer. This guideline updates and replaces the previous ASCO platelet transfusion guideline published initially in 2001. Methods ASCO convened an Expert Panel and conducted a systematic review of the medical literature published from September 1, 2014, through October 26, 2016. This review builds on two 2015 systematic reviews that were conducted by the AABB and the International Collaboration for Transfusion Medicine Guidelines...
November 28, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29181688/expanded-description-of-lamproglena-cleopatra-humes-1957-lernaeidae-copepoda-from-labeo-spp-cyprinidae-with-a-key-to-species-of-lamproglena-von-nordmann-1832
#15
Katlego D Kunutu, Sareh Tavakol, Ali Halajian, Chantelle Baker, Michela Paoletti, Richard A Heckmann, Wilmien J Luus-Powell
The occurrence of the copepod Lamproglena cleopatra Humes, 1957, parasitising freshwater fishes in the Limpopo River System is presented, along with new morphological data. This crustacean was originally described parasitising a cyprinid (Labeo forskalii Rüppell) from the River Nile, Egypt. During 2014-2015 crustacean samples were collected from the gills of three cyprinid fish species, Labeo rosae Steindachner from Flag Boshielo Dam, Labeo molybdinus Du Plessis from Nwanedi-Luphephe Dam in South Africa, and Labeo ruddi Boulenger from the River Bubye in Zimbabwe...
November 27, 2017: Systematic Parasitology
https://www.readbyqxmd.com/read/29174270/are-e-cigarettes-beneficial-for-public-health-hume-s-guillotine-the-debate-continues
#16
EDITORIAL
Sundeep Mishra
Cigarette smoking is the most common preventable cause of death which has led to a search for healthier alternatives to tobacco smoke. Electronic cigarettes are devoid of many harmful constituents found in cigarette smoke and are therefore being positioned as safer alternative to tobacco smoke. The carcinogenic potential may be of lower magnitude compared with cigarette smoke, but it is still there. The use of e-cigarettes, however, is fairly new, so its long-term effects are still unknown. Moreover, they continue to posses the cardiovascular side-effects and are certainly as addicting...
November 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/29171352/the-one-week-and-six-month-reliability-and-variability-of-three-dimensional-tibial-acceleration-in-runners
#17
Kelly R Sheerin, Thor F Besier, Duncan Reid, Patria A Hume
Tibial acceleration is a surrogate measure for impact loading and lower limb fatigue injury in runners. Triaxial accelerometers may offer reliable and practical measurement of resultant peak tibial acceleration (PTA). With such potential in mind, this study examined variability and measurement reliability of tibial acceleration in 14 runners at baseline at one week, and eight of the runners again at six months. Triaxial accelerometers were attached to the distal tibiae of runners before they ran on a treadmill for two minutes each, at speeds of 2...
November 24, 2017: Sports Biomechanics
https://www.readbyqxmd.com/read/29159578/assessing-quality-of-program-environments-for-children-and-youth-with-autism-autism-program-environment-rating-scale-apers
#18
Samuel L Odom, Ann Cox, John Sideris, Kara A Hume, Susan Hedges, Suzanne Kucharczyk, Evelyn Shaw, Brian A Boyd, Stephanie Reszka, Jennifer Neitzel
The purpose of this study was to examine the psychometric properties of the Autism Program Environment Rating Scale (APERS), an instrument designed to assess quality of program environments for students with autism spectrum disorder. Data sets from two samples of public school programs that provided services to children and youth with autism spectrum disorder were utilized. Cronbach alpha analyses indicated high coefficients of internal consistency for the total APERS and moderate levels for item domains for the first data set, which was replicated with the second data set...
November 20, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29157371/australian-horse-owners-and-their-biosecurity-practices-in-the-context-of-hendra-virus
#19
Anke K Wiethoelter, Nicole Schembri, Navneet K Dhand, Kate Sawford, Melanie R Taylor, Barbara Moloney, Therese Wright, Nina Kung, Hume E Field, Jenny-Ann L M L Toribio
In recent years, outbreaks of exotic as well as newly emerging infectious diseases have highlighted the importance of biosecurity for the Australian horse industry. As the first potentially fatal zoonosis transmissible from horses to humans in Australia, Hendra virus has emphasised the need to incorporate sound hygiene and general biosecurity practices into day-to-day horse management. Recommended measures are widely publicised, but implementation is at the discretion of the individual owner. This cross-sectional study aimed to determine current levels of biosecurity of horse owners and to identify factors influencing the uptake of practices utilising data from an online survey...
December 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29122475/head-impact-exposure-from-match-participation-in-women-s-rugby-league-over-one-season-of-domestic-competition
#20
Doug A King, Patria A Hume, Conor Gissane, David C Kieser, Trevor N Clark
OBJECTIVES: To quantify the magnitude, frequency, duration and distribution of head impact exposure in a women's rugby league competition. DESIGN: Prospective cohort study. METHODS: Twenty-one players had a wireless impact measuring device (X2Biosystems XPatch) behind their right ear during match participation. Head impact data were collected and downloaded for analysis. Median peak linear and rotational accelerations and impact locations between player positions were assessed using a Friedman repeated measures ANOVA on ranks with a Wilcoxon signed-rank test for post hoc analysis with a Bonferroni correction...
October 28, 2017: Journal of Science and Medicine in Sport
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