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https://www.readbyqxmd.com/read/29122475/head-impact-exposure-from-match-participation-in-women-s-rugby-league-over-one-season-of-domestic-competition
#1
Doug A King, Patria A Hume, Conor Gissane, David C Kieser, Trevor N Clark
OBJECTIVES: To quantify the magnitude, frequency, duration and distribution of head impact exposure in a women's rugby league competition. DESIGN: Prospective cohort study. METHODS: Twenty-one players had a wireless impact measuring device (X2Biosystems XPatch) behind their right ear during match participation. Head impact data were collected and downloaded for analysis. Median peak linear and rotational accelerations and impact locations between player positions were assessed using a Friedman repeated measures ANOVA on ranks with a Wilcoxon signed-rank test for post hoc analysis with a Bonferroni correction...
October 28, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29112375/gold-polar-intermetallics-structural-versatility-through-exclusive-bonding-motifs
#2
Volodymyr Smetana, Melissa Rhodehouse, Gerd Meyer, Anja-Verena Mudring
The design of new materials with desired chemical and physical characteristics requires thorough understanding of the underlying composition-structure-property relationships and the experimental possibility of their modification through the controlled involvement of new components. From this point of view, intermetallic phases, a class of compounds formed by two or more metals, present an endless field of combinations that produce several chemical compound classes ranging from simple alloys to true ionic compounds...
November 7, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29111304/who-are-they-patients-with-heart-failure-in-american-skilled-nursing-facilities
#3
Lin Li, Bill M Jesdale, Anne Hume, Giovanni Gambassi, Robert J Goldberg, Kate L Lapane
BACKGROUND: Heart failure (HF) is common among skilled nursing facility (SNF) residents, yet patients with HF in the SNF setting have not been well described. METHODS: Using Minimum Data Set 3.0 cross-linked to Medicare data (2011-2012), we studied 150,959 HF patients admitted to 13,858 SNFs throughout the USA. ICD-9 codes were used to differentiate patients with HF with preserved ejection fraction (HFpEF), reduced ejection fraction (HFrEF), or unspecified HF. RESULTS: The median age of the study population was 82 years, 68% were women, 34% had HFpEF, and 27% had HFrEF...
October 27, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/29107337/cd169-macrophages-are-critical-for-osteoblast-maintenance-and-promote-intramembranous-and-endochondral-ossification-during-bone-repair
#4
Lena Batoon, Susan Marie Millard, Martin Eduard Wullschleger, Corina Preda, Andy Chiu-Ku Wu, Simranpreet Kaur, Hsu-Wen Tseng, David Arthur Hume, Jean-Pierre Levesque, Liza Jane Raggatt, Allison Robyn Pettit
Osteal macrophages (osteomacs) contribute to bone homeostasis and regeneration. To further distinguish their functions from osteoclasts, which share many markers and growth factor requirements, we developed a rapid, enzyme-free osteomac enrichment protocol that permitted characterization of minimally manipulated osteomacs by flow cytometry. Osteomacs differ from osteoclasts in expression of Siglec1 (CD169). This distinction was confirmed using the CD169-diphtheria toxin (DT) receptor (DTR) knock-in model. DT treatment of naïve CD169-DTR mice resulted in selective and striking loss of osteomacs, whilst osteoclasts and trabecular bone area were unaffected...
October 22, 2017: Biomaterials
https://www.readbyqxmd.com/read/29094920/distinct-nucleation-and-growth-kinetics-of-amorphous-srtio3-on-001-srtio3-and-sio2-si-a-step-toward-new-architectures
#5
Yajin Chen, M Humed Yusuf, Yingxin Guan, R B Jacobson, Max G Lagally, Susan E Babcock, Thomas F Kuech, Paul G Evans
Integration of emerging complex-oxide compounds into sophisticated nanoscale single-crystal geometries faces significant challenges arising from the kinetics of vapor-phase thin-film epitaxial growth. A comparison of the crystallization of the model perovskite SrTiO3 (STO) on (001) STO and oxidized (001) Si substrates indicates that there is a viable alternative route that can yield three-dimensional epitaxial synthesis, an approach in which STO is crystallized from an amorphous thin film by postdeposition annealing...
November 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29056337/early-life-gene-expression-in-neurons-modulates-lasting-epigenetic-states
#6
Hume Stroud, Susan C Su, Sinisa Hrvatin, Alexander W Greben, William Renthal, Lisa D Boxer, M Aurel Nagy, Daniel R Hochbaum, Benyam Kinde, Harrison W Gabel, Michael E Greenberg
In mammals, the environment plays a critical role in promoting the final steps in neuronal development during the early postnatal period. While epigenetic factors are thought to contribute to this process, the underlying molecular mechanisms remain poorly understood. Here, we show that in the brain during early life, the DNA methyltransferase DNMT3A transiently binds across transcribed regions of lowly expressed genes, and its binding specifies the pattern of DNA methylation at CA sequences (mCA) within these genes...
November 16, 2017: Cell
https://www.readbyqxmd.com/read/29051184/novel-use-of-hydroxyurea-in-an-african-region-with-malaria-noharm-a-trial-for-children-with-sickle-cell-anemia
#7
Robert O Opoka, Christopher M Ndugwa, Teresa S Latham, Adam Lane, Heather A Hume, Phillip Kasirye, James S Hodges, Russell E Ware, Chandy C John
Hydroxyurea treatment is recommended for children with sickle cell anemia (SCA) living in high-resource malaria-free regions, but its safety and efficacy in malaria-endemic sub-Saharan Africa, where the greatest sickle cell burden exists, remain unknown. In vitro studies suggest hydroxyurea could increase malaria severity, and hydroxyurea-associated neutropenia could worsen infections. NOHARM was a randomized, double-blinded, placebo-controlled trial conducted in malaria-endemic Uganda, comparing hydroxyurea to placebo at 20 ± 2...
October 19, 2017: Blood
https://www.readbyqxmd.com/read/29049618/introduction-hearing-across-the-lifespan-heal-2016
#8
Sophia E Kramer, Gabriella Tognola, Larry E Humes
This introduction overviews this special issue on the Hearing Across the Lifespan (HEAL) conference, which was held in Cernobbio, Italy, June 2-4, 2016.
October 12, 2017: American Journal of Audiology
https://www.readbyqxmd.com/read/29020804/multi-informant-assessment-of-transition-related-skills-and-skill-importance-in-adolescents-with-autism-spectrum-disorder
#9
Kara Hume, Jessica Dykstra Steinbrenner, John Sideris, Leann Smith, Suzanne Kucharczyk, Kate Szidon
Adolescents with autism spectrum disorder have limited participation in the transition planning process, despite the link between active participation and an improvement in postsecondary education and employment outcomes. The Secondary School Success Checklist was designed to support transition planning for adolescents with autism spectrum disorder by incorporating their own assessments of strengths, skill deficits, and prioritization for instruction along with those of their parents and teachers across multiple skill domains...
October 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/28975307/effect-of-lorazepam-with-haloperidol-vs-haloperidol-alone-on-agitated-delirium-in-patients-with-advanced-cancer-receiving-palliative-care-a-randomized-clinical-trial
#10
RANDOMIZED CONTROLLED TRIAL
David Hui, Susan Frisbee-Hume, Annie Wilson, Seyedeh S Dibaj, Thuc Nguyen, Maxine De La Cruz, Paul Walker, Donna S Zhukovsky, Marvin Delgado-Guay, Marieberta Vidal, Daniel Epner, Akhila Reddy, Kimerson Tanco, Janet Williams, Stacy Hall, Diane Liu, Kenneth Hess, Sapna Amin, William Breitbart, Eduardo Bruera
Importance: The use of benzodiazepines to control agitation in delirium in the last days of life is controversial. Objective: To compare the effect of lorazepam vs placebo as an adjuvant to haloperidol for persistent agitation in patients with delirium in the setting of advanced cancer. Design, Setting, and Participants: Single-center, double-blind, parallel-group, randomized clinical trial conducted at an acute palliative care unit at MD Anderson Cancer Center, Texas, enrolling 93 patients with advanced cancer and agitated delirium despite scheduled haloperidol from February 11, 2014, to June 30, 2016, with data collection completed in October 2016...
September 19, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28959737/transcriptomic-signatures-of-tacaribe-virus-infected-jamaican-fruit-bats
#11
Diana L Gerrard, Ann Hawkinson, Tyler Sherman, Cassandra M Modahl, Gretchen Hume, Corey L Campbell, Tony Schountz, Seth Frietze
Tacaribe virus (TCRV) is a mammalian arenavirus that was first isolated from artibeus bats in the 1950s. Subsequent experimental infection of Jamaican fruit bats (Artibeus jamaicensis) caused a disease similar to that of naturally infected bats. Although substantial attention has focused on bats as reservoir hosts of viruses that cause human disease, little is known about the interactions between bats and their pathogens. We performed a transcriptome-wide study to illuminate the response of Jamaican fruit bats experimentally infected with TCRV...
September 2017: MSphere
https://www.readbyqxmd.com/read/28941356/computational-approaches-to-identify-genetic-interactions-for-cancer-therapeutics
#12
Graeme Benstead-Hume, Sarah K Wooller, Frances M G Pearl
The development of improved cancer therapies is frequently cited as an urgent unmet medical need. Here we describe how genetic interactions are being therapeutically exploited to identify novel targeted treatments for cancer. We discuss the current methodologies that use 'omics data to identify genetic interactions, in particular focusing on synthetic sickness lethality (SSL) and synthetic dosage lethality (SDL). We describe the experimental and computational approaches undertaken both in humans and model organisms to identify these interactions...
September 23, 2017: Journal of Integrative Bioinformatics
https://www.readbyqxmd.com/read/28940193/prevalence-of-long-term-opioid-use-in-long-stay-nursing-home-residents
#13
Jacob N Hunnicutt, Stavroula A Chrysanthopoulou, Christine M Ulbricht, Anne L Hume, Jennifer Tjia, Kate L Lapane
BACKGROUND/OBJECTIVES: Overall and long-term opioid use among older adults have increased since 1999. Less is known about opioid use in older adults in nursing homes (NHs). DESIGN: Cross-sectional. SETTING: U.S. NHs (N = 13,522). PARTICIPANTS: Long-stay NH resident Medicare beneficiaries with a Minimum Data Set 3.0 (MDS) assessment between April 1, 2012, and June 30, 2012, and 120 days of follow-up (N = 315,949). MEASUREMENTS: We used Medicare Part D claims to measure length of opioid use in the 120 days from the index assessment (short-term: ≤30 days, medium-term: >30-89 days, long-term: ≥90 days), adjuvants (e...
September 21, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28939460/pharmacotherapy-use-in-older-patients-with-heart-failure-and-reduced-ejection-fraction-after-a-skilled-nursing-facility-stay
#14
Lin Li, Bill M Jesdale, Anne Hume, Giovanni Gambassi, Robert J Goldberg, Kate L Lapane
BACKGROUND: Little is known about guideline-directed pharmacotherapy use in patients with heart failure and reduced ejection fraction (HFrEF) discharged to skilled nursing facilities (SNFs). This study aimed to describe the use of angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin receptor blocker (ARBs) and evidence-based β-blockers (EBBBs) among older patients with HFrEF within 90 days after the SNF admission and to identify factors associated with receipt of these medications...
September 20, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28936882/technology-use-as-a-support-tool-by-secondary-students-with-autism
#15
Susan H Hedges, Samuel L Odom, Kara Hume, Ann Sam
The purpose of this study was to examine how secondary students with autism spectrum disorder use technology in supportive ways. In this self-report survey study, 472 adolescents with autism spectrum disorder enrolled in high school described the forms of technology they use and purposes for which they use it. Students reported the benefits as well as barriers to technology use at school. They reported using technology in school and home settings in a variety of supportive ways such as increasing their independence, reducing their anxiety, and increasing their social opportunities...
September 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/28934262/effects-of-eimeria-tenella-infection-on-chicken-caecal-microbiome-diversity-exploring-variation-associated-with-severity-of-pathology
#16
Sarah E Macdonald, Matthew J Nolan, Kimberley Harman, Kay Boulton, David A Hume, Fiona M Tomley, Richard A Stabler, Damer P Blake
Eimeria species cause the intestinal disease coccidiosis, most notably in poultry. While the direct impact of coccidiosis on animal health and welfare is clear, its influence on the enteric microbiota and by-stander effects on chicken health and production remains largely unknown, with the possible exception of Clostridium perfringens (necrotic enteritis). This study evaluated the composition and structure of the caecal microbiome in the presence or absence of a defined Eimeria tenella challenge infection in Cobb500 broiler chickens using 16S rRNA amplicon sequencing...
2017: PloS One
https://www.readbyqxmd.com/read/28931544/a-mitohormetic-response-to-pro-oxidant-exposure-in-the-house-mouse
#17
Yufeng Zhang, Frances Humes, Gregory Almond, Andreas N Kavazis, Wendy R Hood
Mitochondria are hypothesized to display a biphasic response to reactive oxygen species (ROS) exposure. In this study, we evaluated the time course changes in mitochondrial performance and oxidative stress in house mice following X-irradiation. Forty-eight mice were equally divided among six groups, including a non-irradiated control and 5 experimental groups that varied in time between X-ray exposure and euthanasia (1 hour, 1, 4, 7, or 10 days after X-irradiation). We measured parameters associated with mitochondrial respiratory function and ROS emission from isolated liver and skeletal muscle mitochondria and levels of oxidative damage and antioxidants in liver, skeletal muscle, and heart tissues...
September 20, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28931390/who-s-holding-the-baby-a-prospective-diary-study-of-the-contact-patterns-of-mothers-with-an-infant
#18
Patricia Therese Campbell, Jodie McVernon, Niraj Shrestha, Paula M Nathan, Nicholas Geard
BACKGROUND: Models of infectious disease are increasingly utilising empirical contact data to quantify the number of potentially infectious contacts between age groups. While a growing body of data is being collected on contact patterns across many populations, less attention has been paid to the social contacts of young infants. We collected information on the social contacts of primary carers of young infants and investigated their potential for use as a proxy for contacts made by their infant...
September 20, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28925357/restraint-of-presynaptic-protein-levels-by-wnd-dlk-signaling-mediates-synaptic-defects-associated-with-the-kinesin-3-motor-unc-104
#19
Jiaxing Li, Yao V Zhang, Elham Asghari Adib, Doychin T Stanchev, Xin Xiong, Susan Klinedinst, Pushpanjali Soppina, Thomas Robert Jahn, Richard I Hume, Tobias M Rasse, Catherine A Collins
The kinesin-3 family member Unc-104/KIF1A is required for axonal transport of many presynaptic components to synapses, and mutation of this gene results in synaptic dysfunction in mice, flies and worms. Our studies at the Drosophila neuromuscular junction indicate that many synaptic defects in unc-104-null mutants are mediated independently of Unc-104's transport function, via the Wallenda (Wnd)/DLK MAP kinase axonal damage signaling pathway. Wnd signaling becomes activated when Unc-104's function is disrupted, and leads to impairment of synaptic structure and function by restraining the expression level of active zone (AZ) and synaptic vesicle (SV) components...
September 19, 2017: ELife
https://www.readbyqxmd.com/read/28919234/effects-of-periplasmic-chaperones-and-membrane-thickness-on-bama-catalyzed-outer-membrane-protein-folding
#20
Bob Schiffrin, Antonio N Calabrese, Anna J Higgins, Julia R Humes, Alison E Ashcroft, Antreas C Kalli, David J Brockwell, Sheena E Radford
The biogenesis of outer-membrane proteins (OMPs) in gram-negative bacteria involves delivery by periplasmic chaperones to the β-barrel assembly machinery (BAM), which catalyzes OMP insertion into the outer membrane. Here, we examine the effects of membrane thickness, the Escherichia coli periplasmic chaperones Skp and SurA, and BamA, the central subunit of the BAM complex, on the folding kinetics of a model OMP (tOmpA) using fluorescence spectroscopy, native mass spectrometry, and molecular dynamics simulations...
September 15, 2017: Journal of Molecular Biology
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