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https://www.readbyqxmd.com/read/29790089/red-drum-sciaenops-ocellatus-growth-and-expression-of-bile-salt-dependent-lipase-in-response-to-increasing-dietary-lipid-supplementation
#1
Mayra L González-Félix, Delbert M Gatlin, Martin Perez-Velazquez, Ken Webb, Armando García-Ortega, Michael Hume
Sciaenops ocellatus has a long history in aquaculture and many difficulties associated with its commercial culture have been addressed and successfully resolved; nevertheless, further research in lipid nutrition could address more comprehensive questions on the way these nutrients are utilized. The purpose of this study was to evaluate S. ocellatus growth and lipase gene expression in response to increasing dietary lipid supplementation. Four experimental diets were formulated to provide 3, 10, 16, or 23% lipid using menhaden fish oil...
May 22, 2018: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29785730/evidence-of-australian-bat-lyssavirus-infection-in-diverse-australian-bat-taxa
#2
Hume Ernest Field
Historically, Australia was considered free of rabies and rabieslike viruses. Thus, the identification of Australian bat lyssavirus (ABLV) in 1996 in a debilitated bat found by a member of the public precipitated both public health consternation and a revision of lyssavirus taxonomy. Subsequent observational studies sought to elaborate the occurrence and frequency of ABLV infection in Australian bats. This paper describes the taxonomic diversity of bat species showing evidence of ABLV infection to better inform public health considerations...
May 21, 2018: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29781938/physical-demands-of-amateur-domestic-and-representative-netball-in-one-season-in-new-zealand-assessed-using-heart-rate-and-movement-analysis
#3
Doug A King, Cloe Cummins, Patria A Hume, Trevor N Clark
King, DA, Cummins, C, Hume, PA, and Clark, TN. Physical demands of amateur domestic and representative netball in one season in New Zealand assessed using heart rate and movement analysis. J Strength Cond Res XX(X): 000-000, 2018-The purpose of this descriptive cohort study was to describe physical demands of netball for positions and between playing levels using microtechnology. Data were collected from 34 female netball players across 3 teams at different levels (over 19 years representative [O19], under 19 years representative [U19], and open-age amateur club domestic) for 20 games using heart rate and microtechnology data...
May 17, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29778628/environmentally-enriched-pigs-have-transcriptional-profiles-consistent-with-neuroprotective-effects-and-reduced-microglial-activity
#4
S M Brown, S J Bush, K M Summers, D A Hume, A B Lawrence
Environmental enrichment (EE) is widely used to study the effects of external factors on brain development, function and health in rodent models, but very little is known of the effects of EE on the brain in a large animal model such as the pig. Twenty-four young pigs (aged 5 weeks at start of study, 1:1 male: female ratio) were housed in environmentally enriched (EE) pens and provided with additional enrichment stimulation (a bag filled with straw) once daily. Litter, weight and sex matched controls n= (24) were housed in barren (B) conditions...
May 17, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29767845/final-results-from-a-defibrotide-treatment-ind-study-for-patients-with-hepatic-veno-occlusive-disease-sinusoidal-obstruction-syndrome
#5
Nancy A Kernan, Stephan Grupp, Angela R Smith, Sally Arai, Brandon Triplett, Joseph H Antin, Leslie Lehmann, Tsiporah Shore, Vincent T Ho, Nancy Bunin, Massimo Iacobelli, Wei Liang, Robin Hume, William Tappe, Robert Soiffer, Paul Richardson
Hepatic veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a potentially life-threatening complication of haematopoietic stem cell transplant (HSCT) conditioning and chemotherapy. Defibrotide is approved for treatment of hepatic VOD/SOS with pulmonary or renal dysfunction [i.e., multi-organ dysfunction (MOD)] after HSCT in the United States and severe VOD/SOS after HSCT in patients aged older than 1 month in the European Union. Defibrotide was available as an investigational drug by an expanded-access treatment programme (T-IND; NCT00628498)...
May 16, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29748802/binding-of-cu-co-and-cs-to-fluorescent-components-of-natural-organic-matter-nom-from-three-contrasting-sites
#6
Scott Hume, François Caron, Stefan Siemann
Aqueous natural organic matter (NOM) contains different types of functional groups (carboxylic, phenolic, sulfidic, etc.), and hence could change the speciation of metals in environmental systems. This work is a proof-of-concept study on the interaction of three metals (Cu, Co, and Cs) with NOM using fluorescence spectroscopy. The specific aim was to determine the conditional stability constants for these three metals with NOM optical components, obtained from the quenching of fluorescence signals. Three contrasting water types were sampled in Northern Ontario: a pristine source (Cross Rd...
May 10, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29742275/early-intensive-behavioral-intervention-eibi-for-young-children-with-autism-spectrum-disorders-asd
#7
REVIEW
Brian Reichow, Kara Hume, Erin E Barton, Brian A Boyd
BACKGROUND: The rising prevalence of autism spectrum disorders (ASD) increases the need for evidence-based behavioral treatments to lessen the impact of symptoms on children's functioning. At present, there are no curative or psychopharmacological therapies to effectively treat all symptoms of the disorders. Early intensive behavioral intervention (EIBI) is a treatment based on the principles of applied behavior analysis. Delivered for multiple years at an intensity of 20 to 40 hours per week, it is one of the more well-established treatments for ASD...
May 9, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29729082/a-case-series-of-perioperative-variables-in-relation-to-short-term-outcomes-in-pediatric-renal-transplant-recipients
#8
Celine Y Y Goh, Helen Hume-Smith, Nicos Kessaris, Stephen D Marks
Multiple perioperative variables have been shown in existing literature to influence long-term outcomes of pediatric RTx, such as allograft survival. Their impact on short-term outcomes is not as well-documented. This case series aims to investigate the effects of nine perioperative variables on two short-term outcomes in pRTR: 1-week post-operative eGFR and post-operative LOS. A total of 73 pRTR transplanted over 3 years from 2012 to 2014 at a single center were studied retrospectively and statistical analyses were performed...
May 5, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29726055/dogs-with-acute-myeloid-leukemia-or-lymphoid-neoplasms-large-cell-lymphoma-or-acute-lymphoblastic-leukemia-may-have-indistinguishable-mediastinal-masses-on-radiographs
#9
Erin Epperly, Kelly R Hume, Steven Moirano, Tracy Stokol, Joanne Intile, Hollis N Erb, Peter V Scrivani
Acute myeloid leukemia is an uncommon hematopoietic neoplasm of dogs that should be differentiated from lymphoid neoplasms, such as lymphoma, because of different treatment protocols and a worse prognosis. Thoracic radiography is performed frequently in dogs with suspected hematopoietic neoplasia, and detecting a mediastinal mass often prioritizes lymphoma as the most likely diagnosis. However, we have observed a mediastinal mass in several dogs with acute myeloid leukemia and hypothesized that (1) the frequency of a mediastinal mass was higher and (2) the size of the mass was larger in dogs with acute myeloid leukemia compared to dogs with lymphoid neoplasms...
May 3, 2018: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29715078/mapping-of-the-us-domestic-influenza-virologic-surveillance-landscape
#10
Barbara Jester, Joy Schwerzmann, Desiree Mustaquim, Tricia Aden, Lynnette Brammer, Rosemary Humes, Pete Shult, Shahram Shahangian, Larisa Gubareva, Xiyan Xu, Joseph Miller, Daniel Jernigan
Influenza virologic surveillance is critical each season for tracking influenza circulation, following trends in antiviral drug resistance, detecting novel influenza infections in humans, and selecting viruses for use in annual seasonal vaccine production. We developed a framework and process map for characterizing the landscape of US influenza virologic surveillance into 5 tiers of influenza testing: outpatient settings (tier 1), inpatient settings and commercial laboratories (tier 2), state public health laboratories (tier 3), National Influenza Reference Center laboratories (tier 4), and Centers for Disease Control and Prevention laboratories (tier 5)...
July 17, 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29706541/the-egyptian-rousette-genome-reveals-unexpected-features-of-bat-antiviral-immunity
#11
Stephanie S Pavlovich, Sean P Lovett, Galina Koroleva, Jonathan C Guito, Catherine E Arnold, Elyse R Nagle, Kirsten Kulcsar, Albert Lee, Françoise Thibaud-Nissen, Adam J Hume, Elke Mühlberger, Luke S Uebelhoer, Jonathan S Towner, Raul Rabadan, Mariano Sanchez-Lockhart, Thomas B Kepler, Gustavo Palacios
Bats harbor many viruses asymptomatically, including several notorious for causing extreme virulence in humans. To identify differences between antiviral mechanisms in humans and bats, we sequenced, assembled, and analyzed the genome of Rousettus aegyptiacus, a natural reservoir of Marburg virus and the only known reservoir for any filovirus. We found an expanded and diversified KLRC/KLRD family of natural killer cell receptors, MHC class I genes, and type I interferons, which dramatically differ from their functional counterparts in other mammals...
April 18, 2018: Cell
https://www.readbyqxmd.com/read/29690875/cross-species-inference-of-long-non-coding-rnas-greatly-expands-the-ruminant-transcriptome
#12
Stephen J Bush, Charity Muriuki, Mary E B McCulloch, Iseabail L Farquhar, Emily L Clark, David A Hume
BACKGROUND: mRNA-like long non-coding RNAs (lncRNAs) are a significant component of mammalian transcriptomes, although most are expressed only at low levels, with high tissue-specificity and/or at specific developmental stages. Thus, in many cases lncRNA detection by RNA-sequencing (RNA-seq) is compromised by stochastic sampling. To account for this and create a catalogue of ruminant lncRNAs, we compared de novo assembled lncRNAs derived from large RNA-seq datasets in transcriptional atlas projects for sheep and goats with previous lncRNAs assembled in cattle and human...
April 24, 2018: Genetics, Selection, Evolution: GSE
https://www.readbyqxmd.com/read/29689936/the-r%C3%A3-union-fody-and-sonnerat-s-shrew-and-the-validity-of-scientifically-naming-animals-described-without-physical-types
#13
Anthony S Cheke, Julian P Hume
An essential requirement of the current edition of the International Code of Zoological Nomenclature (ICZN 1999) is to designate a holotype or syntypes for a species or subspecies newly described after 1999. Where specimens exist this makes sense (and is indeed essential), but is meaningless when describing a species-group taxon from an old illustration or written account in which specimens were not preserved or even necessarily taken at all. The naming of two species which one or both of us described post-1999 from old accounts without designating types has been singled out as invalid on this basis...
February 21, 2018: Zootaxa
https://www.readbyqxmd.com/read/29686855/a-death-in-the-family-sea-lamprey-petromyzon-marinus-avoidance-of-confamilial-alarm-cues-diminishes-with-phylogenetic-distance
#14
John B Hume, Michael Wagner
Alarm signals released after predator attack function as reliable public information revealing areas of high risk. The utility of this information can extend beyond species boundaries, benefiting heterospecifics capable of recognizing and responding appropriately to the signal. Nonmutually exclusive hypotheses explaining the acquisition of heterospecific reactivity to cues suggest it could be conserved phylogenetically following its evolution in a common ancestor (a species-level effect) and/or learned during periods of shared risk (a population-level effect; e...
April 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29675789/experimental-platform-utilising-melting-curve-technology-for-detection-of-mutations-in-mycobacterium-tuberculosis-isolates
#15
Agnieszka Broda, Vlad Nikolayevskyy, Nicki Casali, Huma Khan, Richard Bowker, Gemma Blackwell, Bhakti Patel, James Hume, Waqar Hussain, Francis Drobniewski
Tuberculosis (TB) remains one of the most deadly infections with approximately a quarter of cases not being identified and/or treated mainly due to a lack of resources. Rapid detection of TB or drug-resistant TB enables timely adequate treatment and is a cornerstone of effective TB management. We evaluated the analytical performance of a single-tube assay for multidrug-resistant TB (MDR-TB) on an experimental platform utilising RT-PCR and melting curve analysis that could potentially be operated as a point-of-care (PoC) test in resource-constrained settings with a high burden of TB...
April 20, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29670058/effective-conversion-of-amide-to-carboxylic-acid-on-polymers-of-intrinsic-microporosity-pim-1-with-nitrous-acid
#16
Wei-Hsuan Wu, Paul Thomas, Paul Hume, Jianyong Jin
Carboxylate-functionalised polymers of intrinsic microporosity (C-PIMs) are highly desirable materials for membrane separation applications. The recently reported method to afford C-PIMs was via an extensive base hydrolysis process requiring 360 h. Herein, a novel and effective method to convert PIM-CONH₂ to C-PIM using nitrous acid was studied. The chemical structure of C-PIM was characterised by ¹H NMR, 13 C NMR, FTIR, elemental analysis, UV-Vis, TGA and TGA-MS. Complete conversion from amide to carboxylic acid groups was confirmed...
April 18, 2018: Membranes
https://www.readbyqxmd.com/read/29662667/genetically-enhanced-t-lymphocytes-and-the-intensive-care-unit
#17
REVIEW
Tiberiu Tat, Huming Li, Catalin-Sorin Constantinescu, Anca Onaciu, Sergiu Chira, Ciprian Osan, Sergiu Pasca, Bobe Petrushev, Vlad Moisoiu, Wilhelm-Thomas Micu, Cristian Berce, Sebastian Tranca, Delia Dima, Ioana Berindan-Neagoe, Jianliang Shen, Ciprian Tomuleasa, Liren Qian
Chimeric antigen receptor-modified T cells (CAR-T cells) and donor lymphocyte infusion (DLI) are important protocols in lymphocyte engineering. CAR-T cells have emerged as a new modality for cancer immunotherapy due to their potential efficacy against hematological malignancies. These genetically modified receptors contain an antigen-binding moiety, a hinge region, a transmembrane domain, and an intracellular costimulatory domain resulting in lymphocyte T cell activation subsequent to antigen binding. In present-day medicine, four generations of CAR-T cells are described depending on the intracellular signaling domain number of T cell receptors...
March 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29652604/an-engineered-human-adipose-collagen-model-for-in-vitro-breast-cancer-cell-migration-studies
#18
Robert David Hume, Lorraine Berry, Stefanie Reichelt, Michael D'Angelo, Jenny Gomm, Ruth Elizabeth Cameron, Christine Watson
Adipocytes are one of the major stromal cell components of the human breast. These cells play a key role in the development of the gland and are implicated in breast tumorigenesis. Frequently, directional stromal collagen I fibres are found surrounding aggressive breast tumours. These fibres enhance breast cancer cell migration and are associated with poor patient prognosis. We sought to recapitulate these stromal components in vitro to provide a 3D model comprising human adipose tissue and anisotropic collagen fibres...
March 8, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29650757/conformational-flexibility-within-the-nascent-polypeptide-associated-complex-enables-its-interactions-with-structurally-diverse-client-proteins
#19
Esther M Martin, Matthew P Jackson, Martin Gamerdinger, Karina Gense, Theodoros K Karamanos, Julia R Humes, Elke Deuerling, Alison E Ashcroft, Sheena E Radford
As newly synthesized polypeptides emerge from the ribosome, it is crucial that they fold correctly. To prevent premature aggregation, nascent chains interact with chaperones that facilitate folding or prevent misfolding until protein synthesis is complete. Nascent polypeptide-associated complex (NAC) is a ribosome-associated chaperone important for protein homeostasis. However, how NAC binds its substrates remains unclear. Using native electrospray ionization MS (ESI MS), limited proteolysis, NMR and cross-linking, we analysed the conformational properties of NAC from Caenorhabditis elegans and studied its ability to bind proteins in different conformational states...
April 12, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29625243/%C3%AE-1-3-glucan-derived-from-euglena-gracilis-and-algamune%C3%A2-enhances-innate-immune-responses-of-red-drum-sciaenops-ocellatus-l
#20
Fernando Y Yamamoto, Fei Yin, Waldemar Rossi, Michael Hume, Delbert M Gatlin
To reduce susceptibility to stressors and diseases, immune-modulators such as β-glucans have been proven effective tools to enhance the innate immune responses of fish. Consequently, commercial sources of this polysaccharide are becoming increasingly more available. Algamune™ is a commercial additive produced from Euglena gracilis, as a source of linear β-1,3-glucan. In order to evaluate the immunomodulatory effects of this β-glucan product, the present study assessed the innate immune parameters of red drum (Sciaenops ocellatus) exposed to Algamune™ ex vivo and in vivo...
April 3, 2018: Fish & Shellfish Immunology
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