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JOURNAL ARTICLE
Laura D Zambrano, Margaret M Newhams, Regina M Simeone, Amanda B Payne, Michael Wu, Amber O Orzel-Lockwood, Natasha B Halasa, Jemima M Calixte, Pia S Pannaraj, Kanokporn Mongkolrattanothai, Julie A Boom, Leila C Sahni, Satoshi Kamidani, Kathleen Chiotos, Melissa A Cameron, Aline B Maddux, Katherine Irby, Jennifer E Schuster, Elizabeth H Mack, Austin Biggs, Bria M Coates, Kelly N Michelson, Katherine E Bline, Ryan A Nofziger, Hillary Crandall, Charlotte V Hobbs, Shira J Gertz, Sabrina M Heidemann, Tamara T Bradford, Tracie C Walker, Stephanie P Schwartz, Mary Allen Staat, Samina S Bhumbra, Janet R Hume, Michele Kong, Melissa S Stockwell, Thomas J Connors, Melissa L Cullimore, Heidi R Flori, Emily R Levy, Natalie Z Cvijanovich, Matt S Zinter, Mia Maamari, Cindy Bowens, Danielle M Zerr, Judith A Guzman-Cottrill, Ivan Gonzalez, Angela P Campbell, Adrienne G Randolph
Pediatric COVID-19 vaccination is effective in preventing COVID-19-related hospitalization, but duration of protection of the original monovalent vaccine during SARS-CoV-2 Omicron predominance merits evaluation, particularly given low coverage with updated COVID-19 vaccines. During December 19, 2021-October 29, 2023, the Overcoming COVID-19 Network evaluated vaccine effectiveness (VE) of ≥2 original monovalent COVID-19 mRNA vaccine doses against COVID-19-related hospitalization and critical illness among U...
April 18, 2024: MMWR. Morbidity and Mortality Weekly Report
#2
JOURNAL ARTICLE
Thor E Andreassen, Donald R Hume, Landon D Hamilton, Sean E Higinbotham, Kevin B Shelburne
Computer representations of three-dimensional (3D) geometries are crucial for simulating systems and processes in engineering and science. In medicine, and more specifically, biomechanics and orthopaedics, obtaining and using 3D geometries is critical to many workflows. However, while many tools exist to obtain 3D geometries of organic structures, little has been done to make them usable for their intended medical purposes. Furthermore, many of the proposed tools are proprietary, limiting their use. This work introduces two novel algorithms based on Generalized Regression Neural Networks (GRNN) and 4 processes to perform mesh morphing and overclosure adjustment...
April 2024: Medical Engineering & Physics
#3
JOURNAL ARTICLE
Simon John Hume, Jacinta Alison Holmes, Alexander James Thompson
No abstract text is available yet for this article.
April 15, 2024: American Journal of Gastroenterology
#4
JOURNAL ARTICLE
Doug King, Patria Hume, Trevor Clark, Jennifer Wethe
AIM: Address deficiencies in access to sports sideline medical care by using a Concussion Check Protocol (CCP) for non-medically-trained people. METHOD: A prospective observational cohort study was undertaken on a single amateur female club-based soccer team over two consecutive years in New Zealand utilising a non-medically trained support person termed a Safety officer. CCP is an extension of the King-Devick test with features such as warning signs and symptoms of concussion built into the application...
April 13, 2024: Journal of the Neurological Sciences
#5
JOURNAL ARTICLE
Eduardo C Humes, Dan V Iosifescu, Jose O Siqueira, Renerio Fraguas
OBJECTIVE: Few studies have focused on medical students and residents' mental health impact on medical residency selection (MRS) performance. The authors evaluated the association of performance in MRS with depressive and anxiety symptoms and with a reported psychiatric diagnosis (rPD). METHODS: The authors enrolled candidates after the second round of MRS examinations at a Brazilian Medical School. Performance was assessed by final grade. Depressive and anxiety symptoms were assessed by the Quick Inventory of Depressive Symptomatology Self-Report (QIDS-SR) and the State-Trait Anxiety Inventory (STAI)...
April 12, 2024: Medical Teacher
#6
JOURNAL ARTICLE
Sara Hatam, Sean Timothy Scully, Sarah Cook, Hywel T Evans, Alastair Hume, Constantinos Kallis, Ian Farr, Chris Orton, Aziz Sheikh, Jennifer K Quint
BACKGROUND: Electronic healthcare records (EHRs) are an important resource for health research that can be used to improve patient outcomes in chronic respiratory diseases. However, consistent approaches in the analysis of these datasets are needed for coherent messaging, and when undertaking comparative studies across different populations. METHODS AND RESULTS: We developed a harmonised curation approach to generate comparable patient cohorts for asthma, chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD) using datasets from within Clinical Practice Research Datalink (CPRD; for England), Secure Anonymised Information Linkage (SAIL; for Wales) and DataLoch (for Scotland) by defining commonly derived variables consistently between the datasets...
2024: Clinical Epidemiology
#7
JOURNAL ARTICLE
Stuart L Goldstein, Nicholas J Ollberding, David J Askenazi, Rajit K Basu, David T Selewski, Kelli A Krallman, Lenar Yessayan, Harvey David Humes
RATIONALE AND OBJECTIVE: Critically ill children with acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT) are at increased risk of death. The selective cytopheretic device (SCD) promotes an immunomodulatory effect at circuit-ionized calcium of <0.40 mmol/L. In an adult CRRT patient study, SCD-treated patients reported improved survival or dialysis independence. We reported safety data from children who received CRRT-SCD therapy and compared outcomes with a historic pediatric CRRT cohort...
April 2024: Kidney medicine
#8
Namita Kalra, Rishi Tyagi, Amit Khatri, Khadeeja Kulood, Puja Sabherwal
BACKGROUND: Benign migratory glossitis or geographic tongue is a chronic recurring inflammatory condition of the oral cavity. With its ephemeral characteristics, there has been reported literature showing its association with the administration of certain drugs including angiogenesis inhibitors. The antiangiogenic drugs act by selectively inhibiting the vascular endothelial growth factor (VEGF) signaling. It has been widely used as an adjunct and a maintenance agent for the treatment of various cancers...
January 2024: International Journal of Clinical Pediatric Dentistry
#9
JOURNAL ARTICLE
Melissa Bates, Christine Pabico, Maricon Dans, Leigh Hume
No abstract text is available yet for this article.
April 1, 2024: Nursing Management
#10
JOURNAL ARTICLE
Sabrina L Lanker, Christopher J Pino, H David Humes, Lakhmir Chawla, Kimberly A Johnston
INTRODUCTION: The manual single lumen alternating micro-batch hemodiafiltration (mSLAMB) system is a closed-loop dialysis system designed to provide kidney support in emergency situations (e.g., fluid overload, hyperkalemia, acidemia). If done repeatedly in small batches and at high flow rates, this system was found to achieve clearance levels comparable to traditional renal replacement therapy (RRT). METHODS: Using a porcine model, uremic toxins and exogenous fluorescent tracer concentrations were successfully lowered within just 1 hour of treatment...
March 27, 2024: Blood Purification
#11
Natalie J Hardaker, Patria A Hume, Stacy T Sims
BACKGROUND: Female sex is a significant determinant of anterior cruciate ligament (ACL) injury. It is not understood if sex is a key determinant of other sports-related injuries. OBJECTIVE: The aim of this systematic review was to identify where differences in injury profiles are most apparent between the sexes in all sports across the six-tiered participant classification framework. METHODS: This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and the 'implementing PRISMA in Exercise, Rehabilitation, Sport medicine and SporTs science'(PERSiST) guidance...
March 27, 2024: Sports Medicine
#12
Taylor P Williams, Mitchell W Cox, Bagi Jana, Merrick I Ross, Sarah B Fisher, John P Walker, Celyne B Hume, Lauren L Mayo, Douglas S Tyler
Locally advanced cutaneous squamous cell carcinoma can erode into blood vessels, leading to vascular blowout, requiring emergent surgical intervention. We describe a first case of this disease complication which was effectively managed with endovascular stenting as a bridge to effective systemic and regional therapy. We discuss the efficacy of this staged approach which is novel and timely in a clinical environment of increasingly effective systemic therapies.
March 27, 2024: Journal of Surgical Oncology
#13
JOURNAL ARTICLE
Andreas Kretschmer, Paul Heinz Mayrhofer
To quickly screen for single-phased multi-principal-element materials, a so-called entropy forming ability (EFA) parameter is sometimes used as a descriptor. The larger the EFA, the larger is the propensity to form a single-phase structure. We have investigated this EFA descriptor with atomic relaxations in special-quasi-random structures and discovered that the EFA correlates inversely with the lattice distortion. Large effective atomic size differences lead to multi-phase compounds, and little size differences to single-phase compounds...
March 26, 2024: Scientific Reports
#14
JOURNAL ARTICLE
M'Bouye Doucoure, Amatigue Zeguime, Amadou Niangaly, Merepen A Guindo, Justin Y A Doritchamou, Mahamadoun H Assadou, Abdoulaye Katile, Moussa B Kanoute, Sidiki Perou, Adama Ouattara, Sintry Sanogo, Boucary Ouologuem, Souleymane Traore, Bakary Dao, Drissa Dembele, Mamady Kone, Bourama Kamate, Kourane Sissoko, Seydou Sankare, Sadio Diarra, Amagana Dolo, Mahamadou S Sissoko, Jennifer C C Hume, David Cook, Sara A Healy, J Patrick Gorres, Boubacar Traoré, Jordyn Gamiel, Patrick E Duffy, Issaka Sagara
The interpretation of a laboratory test result requires an appropriate reference range established in healthy subjects, and normal ranges may vary by factors such as geographic region, sex, and age. We examined hematological and clinical chemistry parameters in healthy residents at two rural vaccine trial sites: Bancoumana and Doneguebougou in Mali, West Africa. During screening of clinical studies in 2018 and 2019, peripheral blood samples from 1,192 apparently healthy individuals age 6 months to 82 years were analyzed at a laboratory accredited by the College of American Pathologists for a complete blood count, and creatinine and/or alanine aminotransferase levels...
March 26, 2024: American Journal of Tropical Medicine and Hygiene
#15
JOURNAL ARTICLE
Catherine Hume, Samantha L Baglot, Lucia Javorcikova, Savannah H M Lightfoot, Jessica Scheufen, Matthew N Hill
BACKGROUND: 4-20% of people report using cannabis during pregnancy, thereby it is essential to assess the associated risks. There is some evidence that prenatal cannabis exposure (PCE) may be associated with increased risk for developing of obesity and diabetes later in life, however this has not been well explored under controlled conditions. The aim of this study was to use a translational THC vapor model in rodents to characterize the effects of PCE on adiposity, glucose metabolism, and feeding patterns in adulthood, with focus on potential sex differences...
March 25, 2024: International Journal of Obesity
#16
JOURNAL ARTICLE
Lena Batoon, Sahar Keshvari, Katharine M Irvine, Eileen Ho, Melanie Caruso, Omkar L Patkar, Anuj Sehgal, Susan M Millard, David A Hume, Allison R Pettit
Macrophage and osteoclast proliferation, differentiation and survival are regulated by colony-stimulating factor-1 receptor (CSF1R) signaling. Osteopetrosis associated with Csf1 and Csf1r mutations has been attributed to the loss of osteoclasts and deficiency in bone resorption. Here we demonstrate that homozygous Csf1r mutation in rat leads to delayed postnatal skeletal ossification associated with substantial loss of osteal macrophages (osteomacs) in addition to osteoclasts. Osteosclerosis and site-specific skeletal abnormalities were reversed by intraperitoneal transfer of wild-type bone marrow cells (BMT) at weaning...
March 25, 2024: Journal of Leukocyte Biology
#17
JOURNAL ARTICLE
Liangxue Sun, Zhouting Tuo, Xin Chen, Huming Wang, Zhaojie Lyu, Guangyuan Li
BACKGROUND: In the context of prostate cancer (PCa), the occurrence of biochemical recurrence (BCR) stands out as a pivotal factor significantly impacting prognosis, potentially leading to metastasis and mortality. However, the early detection of BCR poses a substantial challenge for PCa patients. There is an urgent need to pinpoint hub genes that can serve as predictive indicators for BCR in PCa patients. METHODS: Our primary goal was to identify cell differentiation trajectory-related gene signature in PCa patients by pseudo-time trajectory analysis...
March 30, 2024: Heliyon
#18
JOURNAL ARTICLE
G Cavoto, R Chakraborty, A Doinaki, C Dutsov, M Giovannozzi, T Hume, K Kirch, K Michielsen, L Morvaj, A Papa, F Renga, M Sakurai, P Schmidt-Wellenburg
At the Paul Scherrer Institut (PSI), we are developing a high-precision apparatus with the aim of searching for the muon electric dipole moment (EDM) with unprecedented sensitivity. The underpinning principle of this experiment is the frozen-spin technique, a method that suppresses the spin precession due to the anomalous magnetic moment, thereby enhancing the signal-to-noise ratio for EDM signals. This increased sensitivity enables measurements that would be difficult to achieve with conventional <mml:math xmlns:mml="https://www...
2024: European Physical Journal. C, Particles and Fields
#19
JOURNAL ARTICLE
Dougie Zubizarreta, Andrea L Wirtz, Elizabeth Humes, Erin E Cooney, Meg Stevenson, Keri N Althoff, Asa E Radix, Tonia Poteat, Chris Beyrer, Andrew J Wawrzyniak, Kenneth H Mayer, Sari L Reisner
The prevalence and correlates of food insecurity-the unavailability of food and limited access to it-have not been adequately considered among transgender women (TW), particularly alongside other health-related conditions burdening this population, such as HIV infection. This study examined the prevalence and correlates of food insecurity among TW. Between 2018 and 2020, 1590 TW in the Eastern and Southern U.S. completed a multi-site baseline assessment (socio-behavioral survey and HIV testing). Descriptive statistics were calculated and multivariable Poisson models with robust error variance were used to estimate prevalence ratios and 95% confidence intervals for correlates of food insecurity (dichotomized as sometimes-to-always vs...
February 29, 2024: Nutrients
#20
REVIEW
Mark A Faghy, Rae Duncan, Emily Hume, Lewis Gough, Clare Roscoe, Deepika Laddu, Ross Arena, Ruth E M Asthon, Caroline Dalton
The Post Covid-19 Condition (commonly known as Long Covid) has been defined by the World Health Organisation as occurring in individuals with a history of probable or confirmed SARS CoV 2 infection, usually within 3 months from the onset of acute Covid-19 infection with symptoms that last for at least two months which cannot be explained by an alternative diagnosis. Long Covid is associated with over two hundred recognised symptoms and affects tens of millions of people worldwide. Widely reported reductions in quality of life(QoL) and functional status are caused by extremely sensitive and cyclical symptom profiles that are augmented following exposure to physical, emotional, orthostatic, and cognitive stimuli...
March 8, 2024: Progress in Cardiovascular Diseases
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