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https://www.readbyqxmd.com/read/28430937/high-sugar-but-not-high-fat-food-activates-supraoptic-oxytocin-neurones-in-the-male-rat
#1
Catherine Hume, Nancy Sabatier, John Menzies
Oxytocin is a potent anorexigen and is believed to have a role in satiety signalling. We developed rat models to study the activity of oxytocin neurones in response to voluntary consumption or oral gavage of foods using c-Fos immunohistochemistry and in vivo electrophysiology.Using c-Fos expression as an indirect marker of neural activation, we showed that the percentage of magnocellular oxytocin neurones expressing c-Fos increased with voluntary consumption of sweetened condensed milk (SCM). To model the effect of food in the stomach, we gavaged anaesthetised rats with SCM...
April 19, 2017: Endocrinology
https://www.readbyqxmd.com/read/28423505/identification-and-analysis-of-mutational-hotspots-in-oncogenes-and-tumour-suppressors
#2
Hanadi Baeissa, Graeme Benstead-Hume, Christopher J Richardson, Frances M G Pearl
BACKGROUND: The key to interpreting the contribution of a disease-associated mutation in the development and progression of cancer is an understanding of the consequences of that mutation both on the function of the affected protein and on the pathways in which that protein is involved. Protein domains encapsulate function and position-specific domain based analysis of mutations have been shown to help elucidate their phenotypes. RESULTS: In this paper we examine the domain biases in oncogenes and tumour suppressors, and find that their domain compositions substantially differ...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28372081/hearing-aids-springer-handbook-of-auditory-research-volume-56
#3
Larry E Humes
No abstract text is available yet for this article.
March 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28360925/jmjd6-a-jmjc-dioxygenase-with-many-interaction-partners-and-pleiotropic-functions
#4
REVIEW
Janice Kwok, Marie O'Shea, David A Hume, Andreas Lengeling
Lysyl hydroxylation and arginyl demethylation are post-translational events that are important for many cellular processes. The jumonji domain containing protein 6 (JMJD6) has been reported to catalyze both lysyl hydroxylation and arginyl demethylation on diverse protein substrates. It also interacts directly with RNA. This review summarizes knowledge of JMJD6 functions that have emerged in the last 15 years and considers how a single Jumonji C (JmjC) domain-containing enzyme can target so many different substrates...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28358162/ligands-and-complexes-based-on-piperidine-and-their-exploitation-of-the-ring-opening-polymerisation-of-rac-lactide
#5
Paul McKeown, James Brown-Humes, Matthew G Davidson, Mary F Mahon, Timothy J Woodman, Matthew D Jones
A range of ligands based upon 2-(aminomethyl)piperidine have been successfully complexed to Mg(ii), Zn(ii) and group IV metal centres. These complexes have been characterised both in solution and solid state with different coordination geometries realised dependant on the nature of the ligand. For the Mg(ii) and Zn(ii) complexes, M(1-2)2, were isolated and analysed by DOSY NMR spectroscopy. These ligands also furnished diastereomeric group IV complexes, M(1-2)2(O(i)Pr)2. Group IV salalen and salan complexes, M(4-5)(OR)2 were also found to be diastereomeric in nature, with either β-cis or α-cis geometriesrespectively...
April 11, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28347504/platform-technologies-for-modern-vaccine-manufacturing
#6
Hayley K Charlton Hume, Linda H L Lua
Improved understanding of antigenic components and their interaction with the immune system, as supported by computational tools, permits a sophisticated approach to modern vaccine design. Vaccine platforms provide an effective tool by which strategically designed peptide and protein antigens are modularized to enhance their immunogenicity. These modular vaccine platforms can overcome issues faced by traditional vaccine manufacturing and have the potential to generate safe vaccines, rapidly and at a low cost...
March 24, 2017: Vaccine
https://www.readbyqxmd.com/read/28342189/straight-to-test-colonoscopy-for-two-week-wait-referrals-improves-time-to-diagnosis-of-colorectal-cancer-and-is-feasible-in-a-high-volume-unit
#7
A Banerjea, J Voll, A Chowdhury, A Siddika, S Thomson, R Briggs, D J Humes
AIM: We have introduced "straight-to-test" (STT) colonoscopy as part of our two-week wait (2WW) pathway to address increasing numbers of urgent referrals for colorectal cancer (CRC) with in the National Health Service. In this study we evaluated the ability of this initiative to shorten the time to diagnosis of CRC. METHODS: We amended our 2WW referral form to include performance status and comorbidities. General practitioners were asked to provide data on estimated glomerular filtration rate and full blood count/ferritin...
March 25, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28331397/world-reclassification-of-the-cardiophorinae-coleoptera-elateridae-based-on-phylogenetic-analyses-of-morphological-characters
#8
Hume B Douglas
The prior genus-level classification of Cardiophorinae had never been assessed phylogenetically, and not revised since 1906. A phylogeny for Cardiophorinae and Negastriinae is inferred by Bayesian analyses of 163 adult morphological characters to revise the generic classification. Parsimony analysis is also performed to assess the sensitivity of the Bayesian results to the choice of optimality criterion. Bayesian hypothesis testing rejected monophyly for: Negastriinae; Cardiophorinae (but monophyletic after addition of four taxa); Cardiophorini; cardiophorine genera Aphricus LeConte, 1853; Aptopus Eschscholtz, 1829; Cardiophorus Eschscholtz, 1829; Cardiotarsus Eschscholtz, 1836; Paracardiophorus Schwarz, 1895; Phorocardius Fleutiaux, 1931; Dicronychussensu Platia, 1994; Dicronychussensu Méquignon, 1931; Craspedostethussensu Schwarz, 1906 (i...
2017: ZooKeys
https://www.readbyqxmd.com/read/28331091/ebolaviruses-associated-with-differential-pathogenicity-induce-distinct-host-responses-in-human-macrophages
#9
Judith Olejnik, Adriana Forero, Laure R Deflubé, Adam J Hume, Whitney A Manhart, Andrew Nishida, Andrea Marzi, Michael G Katze, Hideki Ebihara, Angela L Rasmussen, Elke Mühlberger
Ebola virus (EBOV) and Reston virus (RESTV) are members of the Ebolavirus genus which greatly differ in their pathogenicity. While EBOV causes a severe disease in humans characterized by a dysregulated inflammatory response and elevated cytokine and chemokine production, there are no reported disease-associated human cases of RESTV infection, suggesting that RESTV is non-pathogenic for humans. The underlying mechanisms determining the pathogenicity of different ebolavirus species are not yet known. In this study we dissect the host response to EBOV and RESTV infection in primary human monocyte-derived macrophages (MDMs)...
March 22, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28292717/test-retest-reproducibility-of-quantitative-binding-measures-of-11-c-ro15-4513-a-pet-ligand-for-gabaa-receptors-containing-alpha5-subunits
#10
Colm J McGinnity, Daniela A Riaño Barros, Lula Rosso, Mattia Veronese, Gaia Rizzo, Alessandra Bertoldo, Rainer Hinz, Federico E Turkheimer, Matthias J Koepp, Alexander Hammers
INTRODUCTION: Alteration of γ-aminobutyric acid "A" (GABAA) receptor-mediated neurotransmission has been associated with various neurological and psychiatric disorders. [(11)C]Ro15-4513 is a PET ligand with high affinity for α5-subunit-containing GABAA receptors, which are highly expressed in limbic regions of the human brain (Sur et al., 1998). We quantified the test-retest reproducibility of measures of [(11)C]Ro15-4513 binding derived from six different quantification methods (12 variants)...
March 11, 2017: NeuroImage
https://www.readbyqxmd.com/read/28285079/defibrotide-for-patients-with-hepatic-veno-occlusive-disease-sinusoidal-obstruction-syndrome-interim-results-from-a-treatment-ind-study
#11
Paul G Richardson, Angela R Smith, Brandon M Triplett, Nancy A Kernan, Stephan A Grupp, Joseph H Antin, Leslie Lehmann, Tsiporah Shore, Massimo Iacobelli, Maja Miloslavsky, Robin Hume, Alison L Hannah, Bijan Nejadnik, Robert J Soiffer
Hepatic veno-occlusive disease, or sinusoidal obstruction syndrome (VOD/SOS), is a serious and potentially fatal complication of conditioning for hematopoietic stem cell transplantation (HSCT) or of chemotherapy regimens alone. Defibrotide is a complex mixture of single-stranded polydeoxyribonucleotides that is approved in the United States for treating hepatic VOD/SOS with renal or pulmonary dysfunction post-HSCT and in the European Union, Israel, and South Korea for treating severe hepatic VOD/SOS post-HSCT...
March 8, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28272897/magnetic-switching-in-granular-fept-layers-promoted-by-near-field-laser-enhancement
#12
Patrick W Granitzka, Emmanuelle Jal, Loïc Le Guyader, Matteo Savoini, Daniel J Higley, Tianmin Liu, Zhao Chen, Tyler Chase, Hendrik Ohldag, Georgi L Dakovski, William F Schlotter, Sebastian Carron, Matthias C Hoffman, Alexander X Gray, Padraic Shafer, Elke Arenholz, Olav Hellwig, Virat Mehta, Yukiko K Takahashi, Jian Wang, Eric E Fullerton, Joachim Stöhr, Alexander H Reid, Hermann A Dürr
Light-matter interaction at the nanoscale in magnetic materials is a topic of intense research in view of potential applications in next-generation high-density magnetic recording. Laser-assisted switching provides a pathway for overcoming the material constraints of high-anisotropy and high-packing density media, though much about the dynamics of the switching process remains unexplored. We use ultrafast small-angle X-ray scattering at an X-ray free-electron laser to probe the magnetic switching dynamics of FePt nanoparticles embedded in a carbon matrix following excitation by an optical femtosecond laser pulse...
March 17, 2017: Nano Letters
https://www.readbyqxmd.com/read/28263993/analysis-of-the-human-monocyte-derived-macrophage-transcriptome-and-response-to-lipopolysaccharide-provides-new-insights-into-genetic-aetiology-of-inflammatory-bowel-disease
#13
J Kenneth Baillie, Erik Arner, Carsten Daub, Michiel De Hoon, Masayoshi Itoh, Hideya Kawaji, Timo Lassmann, Piero Carninci, Alistair R R Forrest, Yoshihide Hayashizaki, Geoffrey J Faulkner, Christine A Wells, Michael Rehli, Paul Pavli, Kim M Summers, David A Hume
The FANTOM5 consortium utilised cap analysis of gene expression (CAGE) to provide an unprecedented insight into transcriptional regulation in human cells and tissues. In the current study, we have used CAGE-based transcriptional profiling on an extended dense time course of the response of human monocyte-derived macrophages grown in macrophage colony-stimulating factor (CSF1) to bacterial lipopolysaccharide (LPS). We propose that this system provides a model for the differentiation and adaptation of monocytes entering the intestinal lamina propria...
March 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28252160/the-effects-of-service-delivery-model-and-purchase-price-on-hearing-aid-outcomes-in-older-adults-a-randomized-double-blind-placebo-controlled-clinical-trial
#14
Larry E Humes, Sara E Rogers, Tera M Quigley, Anna K Main, Dana L Kinney, Christine Herring
Objectives: The objectives of this study were to determine efficacy of hearing aids in older adults using audiology best practices, to evaluate the efficacy of an alternative over-the-counter (OTC) intervention, and to examine the influence of purchase price on outcomes for both service-delivery models. Design: The design of this study was a single-site, prospective, double-blind placebo-controlled randomized trial with three parallel branches: (a) audiology best practices (AB), (b) consumer decides OTC model (CD), and (c) placebo devices (P)...
March 2, 2017: American Journal of Audiology
https://www.readbyqxmd.com/read/28249093/exploring-use-of-the-coordinate-response-measure-in-a-multitalker-babble-paradigm
#15
Larry E Humes, Gary R Kidd, Daniel Fogerty
Purpose: Three experiments examined the use of competing coordinate response measure (CRM) sentences as a multitalker babble. Method: In Experiment I, young adults with normal hearing listened to a CRM target sentence in the presence of 2, 4, or 6 competing CRM sentences with synchronous or asynchronous onsets. In Experiment II, the condition with 6 competing sentences was explored further. Three stimulus conditions (6 talkers saying same sentence, 1 talker producing 6 different sentences, and 6 talkers each saying a different sentence) were evaluated with different methods of presentation...
March 1, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28228425/prebiotic-supplementation-improves-appetite-control-in-children-with-overweight-and-obesity-a-randomized-controlled-trial
#16
Megan P Hume, Alissa C Nicolucci, Raylene A Reimer
Background: Prebiotics have been shown to improve satiety in adults with overweight and obesity; however, studies in children are limited.Objective: We examined the effects of prebiotic supplementation on appetite control and energy intake in children with overweight and obesity.Design: This study was a randomized, double-blind, placebo-controlled trial. Forty-two boys and girls, ages 7-12 y, with a body mass index (BMI) of ≥85th percentile were randomly assigned to 8 g oligofructose-enriched inulin/d or placebo (maltodextrin) for 16 wk...
February 22, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28211723/sympathetic-ground-state-cooling-and-time-dilation-shifts-in-an-27-al-optical-clock
#17
J-S Chen, S M Brewer, C W Chou, D J Wineland, D R Leibrandt, D B Hume
We report on Raman sideband cooling of ^{25}Mg^{+} to sympathetically cool the secular modes of motion in a ^{25}Mg^{+}-^{27}Al^{+} two-ion pair to near the three-dimensional (3D) ground state. The evolution of the Fock-state distribution during the cooling process is studied using a rate-equation simulation, and various heating sources that limit the efficiency of 3D sideband cooling in our system are discussed. We characterize the residual energy and heating rates of all of the secular modes of motion and estimate a secular motion time-dilation shift of -(1...
February 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28195944/regulatory-advocacy-update-asps-comments-in-response-to-the-fda-draft-guidance-documents-on-human-cell-and-tissue-products
#18
J Peter Rubin, Richard A D'Amico, Ricardo Rodriguez, Sydney R Coleman, Paul Cederna, Scot Glasberg, Michael Neumeister, David H Song, Charles Butler, Keith M Hume
The Food and Drug Administration (FDA) released draft guidance documents on Human Cells, Tissues, and Cellular and Tissue-Based Products (HCT/P) Regulations. These proposed guidance documents can impact the practice of plastic surgery in the area of tissue grafting procedures. This article describes the relevant issues in these draft guidance documents, and presents the comments provided to the FDA by the American Society of Plastic Surgeons (ASPS).
February 9, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28157153/enhancing-the-biological-relevance-of-machine-learning-classifiers-for-reverse-vaccinology
#19
Ashley I Heinson, Yawwani Gunawardana, Bastiaan Moesker, Carmen C Denman Hume, Elena Vataga, Yper Hall, Elena Stylianou, Helen McShane, Ann Williams, Mahesan Niranjan, Christopher H Woelk
Reverse vaccinology (RV) is a bioinformatics approach that can predict antigens with protective potential from the protein coding genomes of bacterial pathogens for subunit vaccine design. RV has become firmly established following the development of the BEXSERO® vaccine against Neisseria meningitidis serogroup B. RV studies have begun to incorporate machine learning (ML) techniques to distinguish bacterial protective antigens (BPAs) from non-BPAs. This research contributes significantly to the RV field by using permutation analysis to demonstrate that a signal for protective antigens can be curated from published data...
February 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28156612/effects-of-high-dose-asian-ginseng-panax-ginseng-to-improve-cancer-related-fatigue-results-of-a-double-blind-placebo-controlled-randomized-controlled-trial
#20
Nizar M Tannir, Janet L Williams, Kenneth R Hess, Susan Frisbee-Hume, Helen L House, Frank V Fossella, Zita Dubauskas Lim, Gabriel Lopez, Akhila Sunkepally Reddy, Ahsan Azhar, Angelique Wong, Sunil M Patel, Ahmed Omar Kaseb, Wen-Jen Hwu, Zhanni Lu, Lorenzo Cohen, Eduardo Bruera
209 Background: Cancer related fatigue (CRF) is the most common and disabling symptom in cancer.Panax ginseng extract (PG) is frequently used as a nutraceutical treatment for fatigue. There are no well-powered placebo-controlled trials that used validated CRF outcome measures to investigate of PG effects in cancer patients. The primary objective of this trial was to evaluate the effects oral PG versus Placebo (PL) for CRF. METHODS: Patients with cancer fatigue ≥ 4/10 on Edmonton Symptom Assessment Scale (ESAS) were eligible...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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