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Keywords atrial fibrillation fibrosis r...

atrial fibrillation fibrosis review

https://read.qxmd.com/read/37777437/factors-associated-with-patent-foramen-ovale-related-stroke-safas-study
#21
JOURNAL ARTICLE
T Pommier, A Lafont, R Didier, L Garnier, G Duloquin, A Meloux, Audrey Sagnard, M Graber, G Dogon, G Laurent, C Vergely, Y Béjot, C Guenancia
BACKGROUND: Persistent foramen ovale (PFO) contributes to cryptogenic stroke and is associated with stroke recurrence, although the exact mechanism of ischemic events is not fully understood. Several biomarkers have been developed for the prediction of atrial fibrillation after stroke, but there are currently only limited data on their potential value for the diagnosis of PFO-related stroke. METHODS: This study was a prospective single-center study that included all patients hospitalized between March 31, 2018, and January 18, 2020, in the stroke department of the Dijon University Hospital for ischemic stroke without obvious cause and without a history of atrial fibrillation...
September 28, 2023: Revue Neurologique
https://read.qxmd.com/read/37773454/the-role-of-galectin-3-in-atrial-fibrillation
#22
REVIEW
Grzegorz Procyk, Aleksandra Czapla, Kamila Jałocha, Agata Tymińska, Marcin Grabowski, Aleksandra Gąsecka
Numerous risk factors for atrial fibrillation (AF) progression have been identified. However, the biomarkers mentioned in the guidelines do not have any clinically relevant predictive value. Some research groups investigated the potential utility of galectin-3 (gal-3) as a diagnostic, prognostic, and predictive biomarker in AF. In this review, we have thoroughly summarized the current data on the role of gal-3 in AF based on the original research in this field. Patients suffering from AF present with increased levels of gal-3...
September 29, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/37760868/pollutants-including-organophosphorus-and-organochloride-pesticides-may-increase-the-risk-of-cardiac-remodeling-and-atrial-fibrillation-a-narrative-review
#23
REVIEW
Ewen Le Quilliec, Alexia Fundere, Doa'a G F Al-U'datt, Roddy Hiram
Atrial fibrillation (AF) is the most common type of cardiac rhythm disorder. Recent clinical and experimental studies reveal that environmental pollutants, including organophosphorus-organochloride pesticides and air pollution, may contribute to the development of cardiac arrhythmias including AF. Here, we discussed the unifying cascade of events that may explain the role of pollutant exposure in the development of AF. Following ingestion and inhalation of pollution-promoting toxic compounds, damage-associated molecular pattern (DAMP) stimuli activate the inflammatory response and oxidative stress that may negatively affect the respiratory, cognitive, digestive, and cardiac systems...
August 30, 2023: Biomedicines
https://read.qxmd.com/read/37741599/epigenetic-micrornas-as-prognostic-markers-of-post-operative-atrial-fibrillation-a-systematic-review
#24
REVIEW
Junsu Lee, Hyunmin Lee, Adham El Sherbini, Leili Baghaie, Fleur Leroy, Husam Abdel-Qadir, Myron R Szewczuk, Mohammad El-Diasty
Post-operative atrial fibrillation (POAF) is a common complication after cardiac surgery, increasing the risk for adverse outcomes such as perioperative and long-term mortality, stroke, myocardial infarction, and other thromboembolic events. Epigenetic biomarkers show promise as prognostic tools for POAF. Epigenetic changes, such as DNA methylation, histone modification, and microRNAs (miRNA), can result in altered gene expression and the development of various pathological conditions. This systematic review aims to present the current literature on the association between various epigenetic markers and the development of POAF following cardiac surgery...
September 21, 2023: Current Problems in Cardiology
https://read.qxmd.com/read/37695505/perspectives-on-secondary-mitral-regurgitation-in-heart-failure
#25
REVIEW
Theo E Meyer, Kai Chen, Matthew W Parker, Jeff Shih, Youssef Rahban
PURPOSE OF THE REVIEW: This review focuses on broader perspectives of mitral regurgitation (MR) in patients with heart failure. RECENT FINDINGS: The ratio of regurgitant volume to end-diastolic volume appears to help identify patients who may benefit from valve interventions. Secondary MR is not only attributed to geometric changes of the LV but also related to the structural changes in the mitral valve that include fibrosis of the mitral leaflets and changes in the extracellular matrix...
September 11, 2023: Current Heart Failure Reports
https://read.qxmd.com/read/37685918/the-role-of-galectin-3-in-heart-failure-the-diagnostic-prognostic-and-therapeutic-potential-where-do-we-stand
#26
REVIEW
Beata Zaborska, Małgorzata Sikora-Frąc, Krzysztof Smarż, Ewa Pilichowska-Paszkiet, Andrzej Budaj, Dariusz Sitkiewicz, Grażyna Sygitowicz
Heart failure (HF) is a clinical syndrome with high morbidity and mortality, and its prevalence is rapidly increasing. Galectin-3 (Gal-3) is an important factor in the pathophysiology of HF, mainly due to its role in cardiac fibrosis, inflammation, and ventricular remodeling. Fibrosis is a hallmark of cardiac remodeling, HF, and atrial fibrillation development. This review aims to explore the involvement of Gal-3 in HF and its role in the pathogenesis and clinical diagnostic and prognostic significance. We report data on Gal-3 structure and molecular mechanisms of biological function crucial for HF development...
August 23, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37641724/the-effectiveness-of-ablation-therapy-for-atrial-fibrillation-a-systematic-review
#27
REVIEW
Arturo P Jaramillo, Luisa Jaramillo, Rebeca R Briones Andriuoli, Jhoanny C Revilla, Javier Castells, Sabina Ibrahimli, Jossua L Villacres, Neyla Garzon Mora
It is expected that the prevalence of atrial fibrillation (AF), the most prevalent cardiac arrhythmia among people aged 65 to 85, would be mostly classified using the CHAS2DS2-VASc approach for anticoagulation therapy. A high number of people in the entire world will be living with AF by 2030. Long-term follow-up data are sparse, although radiofrequency catheter ablation (CA) for symptomatic AF patients has the potential to be a curative therapy. Although women are referred later and less often than men, the outcomes following ablation are comparable across both genders...
August 2023: Curēus
https://read.qxmd.com/read/37608882/effects-of-inflammatory-cell-death-caused-by-catheter-ablation-on-atrial-fibrillation
#28
REVIEW
Dishiwen Liu, Yajia Li, Qingyan Zhao
Atrial fibrillation (AF) poses a serious healthcare burden on society due to its high morbidity and the resulting serious complications such as thrombosis and heart failure. The principle of catheter ablation is to achieve electrical isolation by linear destruction of cardiac tissue, which makes AF a curable disease. Currently, catheter ablation does not have a high long-term success rate. The current academic consensus is that inflammation and fibrosis are central mechanisms in the progression of AF. However, artificially caused inflammatory cell death by catheter ablation may have a significant impact on structural and electrical remodeling, which may affect the long-term prognosis...
2023: Journal of Inflammation Research
https://read.qxmd.com/read/37530946/covid-19-vaccination-and-cardiac-arrhythmias-a-review
#29
REVIEW
Bavithra Pari, Akhilesh Babbili, Ayeesha Kattubadi, Anuj Thakre, Sahithreddy Thotamgari, Rakesh Gopinathannair, Brian Olshansky, Paari Dominic
PURPOSE OF REVIEW: In this review, we aim to delve into the existing literature, seeking to uncover the mechanisms, investigate the electrocardiographic changes, and examine the treatment methods of various cardiac arrhythmias that occur after administration of the COVID-19 vaccine. RECENT FINDINGS: A global survey has exposed an incidence of arrhythmia in 18.27% of hospitalized COVID-19 patients. Furthermore, any type of COVID-19 vaccine - be it mRNA, adenovirus vector, whole inactivated, or protein subunit - appears to instigate cardiac arrhythmias...
September 2023: Current Cardiology Reports
https://read.qxmd.com/read/37516824/obesity-and-atrial-fibrillation-a-narrative-review-from-arrhythmogenic-mechanisms-to-clinical-significance
#30
REVIEW
Hongyang Shu, Jia Cheng, Na Li, Zixuan Zhang, Jiali Nie, Yizhong Peng, Yan Wang, Dao Wen Wang, Ning Zhou
The prevalence of obesity and atrial fibrillation (AF), which are inextricably linked, is rapidly increasing worldwide. Obesity rates are higher among patients with AF than healthy individuals. Some epidemiological data indicated that obese patients were more likely to develop AF, but others reported no significant correlation. Obesity-related hypertension, diabetes, and obstructive sleep apnea are all associated with AF. Additionally, increased epicardial fat, systemic inflammation, and oxidative stress caused by obesity can induce atrial enlargement, inflammatory activation, local myocardial fibrosis, and electrical conduction abnormalities, all of which led to AF and promoted its persistence...
July 29, 2023: Cardiovascular Diabetology
https://read.qxmd.com/read/37467828/microrna-382-as-a-tumor-suppressor-roles-in-tumorigenesis-and-clinical-significance
#31
REVIEW
Mehdi Fattahi, Saeid Shahrabi, Fatemeh Saadatpour, Delsuz Rezaee, Zahra Beyglu, Sana Delavari, Anita Amrolahi, Shirin Ahmadi, Saeid Bagheri-Mohammadi, Effat Noori, Jamal Majidpoor, Shadi Nouri, Seyed Mohsen Aghaei-Zarch, Shahab Falahi, Sajad Najafi, Binh Nguyen Le
MicroRNAs (miRNAs) are small single-stranded RNAs belonging to a class of non-coding RNAs with an average length of 18-22 nucleotides. Although not able to encode any protein, miRNAs are vastly studied and found to play role in various human physiologic as well as pathological conditions. A huge number of miRNAs have been identified in human cells whose expression is straightly regulated with crucial biological functions, while this number is constantly increasing. miRNAs are particularly studied in cancers, where they either can act with oncogenic function (oncomiRs) or tumor-suppressors role (referred as tumor-suppressor/oncorepressor miRNAs)...
July 17, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/37371131/mechanisms-of-atrial-fibrillation-in-obstructive-sleep-apnoea
#32
REVIEW
James Saleeb-Mousa, Demitris Nathanael, Andrew M Coney, Manish Kalla, Keith L Brain, Andrew P Holmes
Obstructive sleep apnoea (OSA) is a strong independent risk factor for atrial fibrillation (AF). Emerging clinical data cite adverse effects of OSA on AF induction, maintenance, disease severity, and responsiveness to treatment. Prevention using continuous positive airway pressure (CPAP) is effective in some groups but is limited by its poor compliance. Thus, an improved understanding of the underlying arrhythmogenic mechanisms will facilitate the development of novel therapies and/or better selection of those currently available to complement CPAP in alleviating the burden of AF in OSA...
June 19, 2023: Cells
https://read.qxmd.com/read/37367420/the-complex-but-fascinating-relationship-between-sport-and-atrial-fibrillation-from-pathophysiology-to-the-clinical-scenario
#33
REVIEW
Mario Tatangelo, Marco Rebecchi, Marianna Sgueglia, Alessandra Colella, Cinzia Crescenzi, Germana Panattoni, Pellegrino Ciampi, Oreste Lanza, Emanuele Canali, Leonardo Calò
Atrial fibrillation (AF) is the most common cause of hospital admission among all arrhythmias in the general population. Moreover, AF represents the most common arrhythmia in the athletic population as well. The complex but fascinating relationship between sport and atrial fibrillation has not yet been fully clarified. Although the benefits of moderate physical activity in controlling cardiovascular risk factors and in reducing the risk of atrial fibrillation have been widely demonstrated, some concerns have been raised about the potential adverse effects of physical activity...
June 11, 2023: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/37293559/the-role-of-major-inflammatory-biomarkers-in-the-pathogenesis-of-atrial-fibrillation
#34
JOURNAL ARTICLE
Saira Rafaqat, Shaheed Afzal, Huma Khurshid, Sanober Safdar, Sana Rafaqat, Simon Rafaqat
Many studies have reported a relationship between inflammation and atrial fibrillation (AF). According to the literature, inflammation is the key component in pathophysiological processes during the development of AF; the amplification of inflammatory pathways triggers AF, and, at the same time, AF increases the inflammatory state. The plasma levels of several inflammatory biomarkers are elevated in patients with AF; therefore, inflammation might contribute to both the maintenance and occurrence of AF and its thromboembolic complications...
December 2022: Journal of Innovations in Cardiac Rhythm Management
https://read.qxmd.com/read/37288203/the-liver-heart-connection-a-literature-review-of-liver-disease-as-a-risk-factor-for-atrial-fibrillation
#35
REVIEW
Mukosolu F Obi, Arianna Reinberg Palmar, Vikhyath Namireddy, Frederick N Campos, Hyun Joon Cho
Atrial fibrillation (AFib) is a common type of cardiac arrhythmia, characterized by disorganized atrial electrical activity with features of irregularly irregular heart rhythm and often with rapid ventricular response increasing the risk of stroke and heart failure due to tachyarrhythmia. The pathophysiology mechanism of AFib is either triggered by atrial distension, abnormality in conducting system, catecholamine excess, or increased atrial irritation or automaticity. Risk factors include uncontrolled diabetes, obesity, obstructive sleep apnea, hypothyroidism, and certain stimulants...
May 2023: Curēus
https://read.qxmd.com/read/37239123/biomarkers-of-atrial-fibrillation-recurrence-in-patients-with-paroxysmal-or-persistent-atrial-fibrillation-following-external-direct-current-electrical-cardioversion
#36
REVIEW
Ozan Demirel, Alexander E Berezin, Moritz Mirna, Elke Boxhammer, Sarah X Gharibeh, Uta C Hoppe, Michael Lichtenauer
Atrial fibrillation (AF) is associated with atrial remodeling, cardiac dysfunction, and poor clinical outcomes. External direct current electrical cardioversion is a well-developed urgent treatment strategy for patients presenting with recent-onset AF. However, there is a lack of accurate predictive serum biomarkers to identify the risks of AF relapse after electrical cardioversion. We reviewed the currently available data and interpreted the findings of several studies revealing biomarkers for crucial elements in the pathogenesis of AF and affecting cardiac remodeling, fibrosis, inflammation, endothelial dysfunction, oxidative stress, adipose tissue dysfunction, myopathy, and mitochondrial dysfunction...
May 16, 2023: Biomedicines
https://read.qxmd.com/read/37169841/construction-and-integrated-analysis-of-the-cerna-network-hsa_circ_0000672-mir-516a-5p-traf6-and-its-potential-function-in-atrial-fibrillation
#37
JOURNAL ARTICLE
Xing Liu, Mingxing Wu, Yan He, Chun Gui, Weiming Wen, Zhiyuan Jiang, Guoqiang Zhong
Atrial fibrosis is a crucial contributor to initiation and perpetuation of atrial fibrillation (AF). This study aimed to identify a circRNA-miRNA-mRNA competitive endogenous RNA (ceRNA) regulatory network related to atrial fibrosis in AF, especially to validate hsa_circ_0000672/hsa_miR-516a-5p/TRAF6 ceRNA axis in AF preliminarily. The circRNA-miRNA-mRNA ceRNA network associated with AF fibrosis was constructed using bioinformatic tools and literature reviews. Left atrium (LA) low voltage was used to represent LA fibrosis by using LA voltage matrix mapping...
May 11, 2023: Scientific Reports
https://read.qxmd.com/read/36964672/the-role-of-interleukins-in-pathogenesis-and-prognosis-of-atrial-fibrillation
#38
JOURNAL ARTICLE
Mohammad Erfan Lotfi, Parmida Sadat Pezeshki, Nima Rezaei
INTRODUCTION: Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia. Moreover, it is mentioned as one of the important causes of death due to heart disease, which imposes an undeniable financial burden on public health systems. Almost 1 out of 4 individuals aged 40 to 55 will experience AF at some point during their life. Increasing the pressure or the volume of the atria over time leads to the activation of fibroblasts, resulting in the accumulation of extracellular matrix and fibrosis...
March 25, 2023: Expert Review of Clinical Immunology
https://read.qxmd.com/read/36909314/direct-and-indirect-effects-of-fibroblast-growth-factor-23-on-the-heart
#39
REVIEW
Toshiaki Nakano, Hiroshi Kishimoto, Masanori Tokumoto
Fibroblast growth factor (FGF)23 is a bone-derived phosphotropic hormone that regulates phosphate and mineral homeostasis. Recent studies have provided evidence that a high plasma concentration of FGF23 is associated with cardiac disease, including left ventricular hypertrophy (LVH), heart failure, atrial fibrillation, and cardiac death. Experimental studies have shown that FGF23 activates fibroblast growth factor receptor 4 (FGFR4)/phospholipase Cγ/calcineurin/nuclear factor of activated T-cells signaling in cardiomyocytes and induces cardiac hypertrophy in rodents...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/36876051/emerging-role-of-mirnas-in-the-regulation-of-ferroptosis
#40
REVIEW
Reza Mahmoudi-Lamouki, Sepideh Kadkhoda, Bashdar Mahmud Hussen, Soudeh Ghafouri-Fard
Ferroptosis is a kind of cell death which has distinctive features differentiating it from autophagy, necrosis and apoptosis. This iron-dependent form of cell death is described by an increase in lipid reactive oxygen species, shrinkage of mitochondria and decrease in mitochondrial cristae. Ferroptosis is involved in the initiation and progression of many diseases and is regarded as a hotspot of investigations on treatment of disorders. Recent studies have shown that microRNAs partake in the regulation of ferroptosis...
2023: Frontiers in Molecular Biosciences
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