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https://www.readbyqxmd.com/read/29776574/incidence-of-bleeding-in-patients-with-atrial-fibrillation-and-advanced-liver-fibrosis-on-treatment-with-vitamin-k-or-non-vitamin-k-antagonist-oral-anticoagulants
#1
Daniele Pastori, Gregory Y H Lip, Alessio Farcomeni, Francesco Del Sole, Angela Sciacqua, Francesco Perticone, Rossella Marcucci, Elisa Grifoni, Pasquale Pignatelli, Francesco Violi
OBJECTIVES: To investigate the incidence of bleeding events in atrial fibrillation (AF) patients treated with vitamin K (VKAs) or non-vitamin K antagonist oral anticoagulants (NOACs) screened for the presence of liver fibrosis (LF). BACKGROUND: Previous studies provided conflicting results on bleeding risk in AF patients with liver disease on VKAs, and no data on NOACs in this setting are available. METHODS: Post-hoc analysis of a prospective, observational multicentre study including 2330 AF outpatients treated with VKAs (n = 1297) or NOACs (n = 1033)...
August 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29770366/complete-resolution-of-left-atrial-appendage-thrombosis-with-oral-dabigatran-etexilate-in-a-patient-with-myotonic-dystrophy-type-1-and-atrial-fibrillation
#2
Anna Rago, Andrea Antonio Papa, Giulia Arena, Marco Mosella, Antonio Cassese, Alberto Palladino, Paolo Golino
Myotonic Dystrophy type 1 (DM1) is the most common muscular dystrophy in adult life characterized by muscle dysfunction and cardiac conduction abnormalities. Atrial fibrillation frequently occurs in DM1 patients. It's related to the discontinuous and inhomogeneous propagation of sinus impulses and to the prolongation of atrial conduction time, caused by progressive fibrosis and fatty replacement of the myocardium. AF predisposes to a hyper-coagulable state and to an increased risk of thromboembolism. We report the first case of complete resolution of left atrial appendage thrombosis with oral dabigatran etexilate in a myotonic dystrophy type I patient with atrial fibrillation scheduled for transesophageal echocardiogram-guided direct current cardioversion...
December 2017: Acta Myologica: Myopathies and Cardiomyopathies: Official Journal of the Mediterranean Society of Myology
https://www.readbyqxmd.com/read/29759774/assessment-of-left-atrial-fibrosis-by-late-gadolinium-enhancement-magnetic-resonance-imaging-methodology-and-clinical-implications
#3
REVIEW
Johannes Siebermair, Eugene G Kholmovski, Nassir Marrouche
Recently, studies using late gadolinium enhancement (LGE) magnetic resonance imaging (MRI) to identify structural changes of atrial tissue have contributed significantly to understanding the pathophysiology and progression of atrial fibrillation (AF). Moreover, imaging of atrial fibrosis using MRI has evolved to be a tool to improve clinical outcome of AF ablation procedures by allowing a patient-specific individualized management approach. LGE-MRI has been shown to predict AF ablation outcome based on pre-procedural imaging to define the extent of atrial fibrosis...
August 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29759716/atrial-fibrillation-in-athletes-a-lesson-in-the-virtue-of-moderation
#4
REVIEW
N A Mark Estes, Christopher Madias
Although the cardiovascular benefits of moderate exercise are well established, there is growing epidemiological support for the notion that high-intensity endurance athletics increases the risk of atrial fibrillation (AF). There are many gaps in evidence related to epidemiology and mechanisms of AF in endurance athletes. The proposed pathophysiological mechanisms include alterations of autonomic tone, electrical remodeling, anatomical remodeling, fibrosis, and inflammation. Clinical management of the athlete with AF often includes a period of decreased frequency, intensity, and duration of exercise with assessment for improvement in AF recurrence...
September 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29759532/therapeutic-approaches-to-atrial-fibrillation-ablation-targeting-atrial-fibrosis
#5
REVIEW
Hans Kottkamp, Doreen Schreiber, Fabian Moser, Andreas Rieger
Atrial fibrosis is the fundamental histopathologic finding in atrial fibrillation (AF) patients and an important predictor of ablation failure beyond pulmonary vein isolation. There is wide variation in the extent and localization of left atrial fibrosis in patients with paroxysmal and nonparoxysmal AF. Box isolation of fibrotic areas is an effective rhythm control concept in patients with paroxysmal AF despite durable pulmonary vein isolation, and this strategy has recently been implemented successfully in initial AF ablation procedures in addition to pulmonary vein isolation for patients with nonparoxysmal AF...
July 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29754423/imaging-mass-spectrometry-for-characterization-of-atrial-fibrillation-subtypes
#6
Oliver Klein, Thorsten Hanke, Grit Nerbrich, Junfeng Yan, Benedikt Schubert, Patrick Giavalisco, Frank Noack, Herbert Thiele, Salah A Mohamed
PURPOSE: Atrial fibrillation (AF) is a cardiac arrhythmia characterized by a rapid and irregular heart rhythm. AF types, paroxysmal (PX), persistent (PE) and long-lasting persistent (LSP), requires differences in clinical management. Unfortunately, a significant proportion of AF patients are clinical misclassified. Therefore, our study aim that MALDI-Imaging (IMS) is valuable as a diagnostic aid in AF subtypes assessment. EXPERIMENTAL DESIGN: Patients were clinically classified according guidelines of the European Society of Cardiology...
May 13, 2018: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29748196/interleukin-10-treatment-ameliorates-high-fat-diet-induced-inflammatory-atrial-remodeling-and-fibrillation
#7
(no author information available yet)
BACKGROUND: Obesity, characterized by systemic low-grade inflammation, is considered a well-known risk for atrial fibrillation. In fact, IL-10 (interleukin 10), which is a potent anti-inflammatory cytokine, has been reported to decrease in obese and diabetic patients. We tested the hypotheses forwarding that genetic deletion of IL-10 exacerbates high-fat diet (HFD)-induced obesity-caused atrial inflammation, lipidosis, fibrosis, and fibrillation and that IL-10 therapy inhibits this pathology...
May 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29725307/comparing-reentrant-drivers-predicted-by-image-based-computational-modeling-and-mapped-by-electrocardiographic-imaging-in-persistent-atrial-fibrillation
#8
Patrick M Boyle, Joe B Hakim, Sohail Zahid, William H Franceschi, Michael J Murphy, Edward J Vigmond, Rémi Dubois, Michel Haïssaguerre, Mélèze Hocini, Pierre Jaïs, Natalia A Trayanova, Hubert Cochet
Electrocardiographic mapping (ECGI) detects reentrant drivers (RDs) that perpetuate arrhythmia in persistent AF (PsAF). Patient-specific computational models derived from late gadolinium-enhanced magnetic resonance imaging (LGE-MRI) identify all latent sites in the fibrotic substrate that could potentially sustain RDs, not just those manifested during mapped AF. The objective of this study was to compare RDs from simulations and ECGI (RDsim /RDECGI ) and analyze implications for ablation. We considered 12 PsAF patients who underwent RDECGI ablation...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29721673/linagliptin-prevents-atrial-electrical-and-structural-remodeling-in-a-canine-model-of-atrial-fibrillation
#9
Tazuru Igarashi, Shinichi Niwano, Hiroe Niwano, Tomoharu Yoshizawa, Hironori Nakamura, Hidehira Fukaya, Tamami Fujiishi, Naruya Ishizue, Akira Satoh, Jun Kishihara, Masami Murakami, Junya Ako
Dipeptidyl peptidase 4 (DPP-4) inhibitors have recently been reported to exhibit additional cardioprotective effects; however, their effect in atrial remodeling, such as in atrial fibrillation (AF), remains unclear. In this study, the effect of linagliptin on atrial electrical and structural remodeling was evaluated in a canine AF model. Sixteen beagle dogs with 3-week atrial rapid stimulation were divided into the linagliptin group (9 mg/kg/day, n = 8) and pacing control group (n = 8). Three additional dogs without rapid pacing were assigned into non-pacing group, which was used as sham in this study...
May 2, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29720500/xanthine-oxidase-inhibitor-allopurinol-prevents-oxidative-stress-mediated-atrial-remodeling-in-alloxan-induced-diabetes-mellitus-rabbits
#10
Yajuan Yang, Jianping Zhao, Jiuchun Qiu, Jian Li, Xue Liang, Zhiwei Zhang, Xiaowei Zhang, Huaying Fu, Panagiotis Korantzopoulos, Konstantinos P Letsas, Gary Tse, Guangping Li, Tong Liu
BACKGROUND: There are several mechanisms, including inflammation, oxidative stress and abnormal calcium homeostasis, involved in the pathogenesis of atrial fibrillation. In diabetes mellitus (DM), increased oxidative stress may be attributable to higher xanthine oxidase activity. In this study, we examined the relationship between oxidative stress and atrial electrical and structural remodeling, and calcium handling abnormalities, and the potential beneficial effects of the xanthine oxidase inhibitor allopurinol upon these pathological changes...
May 2, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29713820/diagnostic-value-of-electrocardiographic-p-wave-characteristics-in-atrial-fibrillation-recurrence-and-tachycardia-induced-cardiomyopathy-after-catheter-ablation
#11
Atsushi Doi, Masahiko Takagi, Hisashi Katayama, Tomotaka Yoshiyama, Yusuke Hayashi, Hiroaki Tatsumi, Minoru Yoshiyama
Abnormal P-wave characteristics were reportedly associated with left ventricular interstitial fibrosis as defined by cardiac magnetic resonance images. The objective of this study is to investigate the utility of P-wave characteristics to predict atrial fibrillation (AF) recurrence and the recovery of left ventricular systolic dysfunction (LVSD) after catheter ablation (CA) for AF. Two hundred and five AF patients (109 paroxysmal and 96 persistent) who underwent CA were enrolled. We measured maximum P-wave duration (max PWD) and P-wave terminal force in lead V1 (PTFV1) calculated as a product of P-wave terminal amplitude (PTaV1) and duration (PTdV1) in lead V1 during sinus rhythm...
April 30, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29690710/-relationship-between-fgf23-fgfr4-expression-in-atrial-tissue-and-atrial-fibrosis-in-patients-with-atrial-fibrillation
#12
Q B Dong, Y H Tang, W X Wang, Y B Wu, L Han, J X Li, K Hong, Y Q Wu, Q H Wu, X S Cheng
Objective: To observe the expression of fibroblast growth factor 23 (FGF23) and FGFR4 in patients with atrial fibrillation (AF) and its relationship with atrial fibrosis. Methods: Fifty-one patients with rheumatic heart disease undergoing cardiac surgery at the Second Affiliated Hospital of Nanchang University from October 2016 to April 2017 were divided into two groups according to whether they were complicated with atrial fibrillation: 39 patients with persistent AF(AF group), and 12 patients with sinus rhythm (SR group)...
April 3, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29676832/circulating-mirnas-in-acute-new-onset-atrial-fibrillation-and-their-target-mrna-network
#13
Ananília Medeiros Gomes da Silva, Jéssica Nayara Góes de Araújo, Katiene Macêdo de Oliveira, Ana Eloísa Melo Novaes, Mariana Borges Lopes, Júlio César Vieira de Sousa, Antônio Amorim de Araújo Filho, André Ducati Luchessi, Adriana Augusto de Rezende, Mário Hiroyuki Hirata, Vivian Nogueira Silbiger
BACKGROUND: MicroRNAs (miRNAs) are involved in the pathogenesis of atrial fibrillation (AF), acting on development and progression. Our pilot study investigated the expression of six miRNAs and their miRNA-mRNA interactions in patients with acute new-onset AF, well-controlled AF, and normal sinus rhythm (controls). METHODS AND RESULTS: Plasma of acute new-onset AF patients (n = 5) was collected in the emergency room when patients presented with irregular and fast-atrial fibrillation rhythm...
April 20, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29671258/atrial-overexpression-of-microrna-27b-attenuates-angiotensin-ii-induced-atrial-fibrosis-and-fibrillation-by-targeting-alk5
#14
Yanshan Wang, Heng Cai, Hongmei Li, Zhisheng Gao, Kunqing Song
Atrial fibrosis influences atrial fibrillation (AF) development by transforming growth factor beta 1 (TGF-β1)/Smad pathway. Although microRNAs are implicated in the pathogenesis of various diseases, information regarding the functional role of microRNAs in atrial dysfunction is limited. In the present study, we found that microRNA-27b (miR-27b) was the dominant member of miR-27 family expressed in left atrium. Moreover, the expression of miR-27b was significantly reduced after angiotensin II (AngII) infusion...
April 18, 2018: Human Cell
https://www.readbyqxmd.com/read/29669504/atrial-fibrillation-in-autoimmune-rheumatic-diseases-from-the-pathogenesis-to-the-treatment
#15
Giuseppe Ciconte, Manuel Conti, Martina Evangelista, Carlo Pappone
BACKGROUND: Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia in the general population and is associated with an increased number of adverse outcomes. The onset and maintenance of this arrhythmia requires a trigger event and the presence of a predisposing substrate. Atrial fibrosis, a major characteristic of AF-related structural remodeling, represents a process closely related to inflammation as demonstrated by emerging evidence. Aim of this article is to review the evidence linking AF to systemic autoimmune diseases...
April 17, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29658562/microrna%C3%A2-34a-mediates-atrial-fibrillation-through-regulation-of-ankyrin%C3%A2-b-expression
#16
Yun Zhu, Zezhou Feng, Wei Cheng, Yingbin Xiao
Atrial fibrillation (AF) has a high prevalence and recurrence rate, and is associated with substantial mortality. However, its underlying mechanisms are not thoroughly understood. Increasing attention has been paid to the roles of microRNAs (miRs) in the pathogenesis of cardiovascular disease, including miR‑1 and miR‑133 (in the electrophysiological response), and miR‑34a (in cardiac fibrosis). Recently, Ankyrin‑B (Ank‑B), an adaptor protein, has been demonstrated to be associated with AF. As a predicted target gene of miR‑34a, the present study aimed to investigate if miR‑34a has a role in AF via regulation of Ank‑B expression...
April 12, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29623658/atrial-fibrillation-in-patients-with-heart-failure-current-state-and-future-directions
#17
REVIEW
Tuoyo O Mene-Afejuku, Persio D López, Adedoyin Akinlonu, Carissa Dumancas, Ferdinand Visco, Savi Mushiyev, Gerald Pekler
Heart failure affects nearly 26 million people worldwide. Patients with heart failure are frequently affected with atrial fibrillation, and the interrelation between these pathologies is complex. Atrial fibrillation shares the same risk factors as heart failure. Moreover, it is associated with a higher-risk baseline clinical status and higher mortality rates in patients with heart failure. The mechanisms by which atrial fibrillation occurs in a failing heart are incompletely understood, but animal studies suggest they differ from those that occur in a healthy heart...
April 5, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/29600783/a-secret-marriage-between-fibrosis-and-atrial-fibrillation-drivers
#18
EDITORIAL
Vadim V Fedorov, Brian J Hansen
No abstract text is available yet for this article.
January 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29593565/aerobic-interval-training-prevents-age-dependent-vulnerability-to-atrial-fibrillation-in-rodents
#19
Vegard Malmo, Allen Kelly, Karin S Garten, Tomas Stolen, Natale P L Rolim, Ulrik Wisloff, Godfrey Smith, Jan P Loennechen
Aims: Increasing age is the most important risk factor for atrial fibrillation (AF). Very high doses of exercise training might increase AF risk, while moderate levels seem to be protective. This study aimed to examine the effects of age on vulnerability to AF and whether long-term aerobic interval training (AIT) could modify these effects. Methods: Nine months old, male Sprague-Dawley rats were randomized to AIT for 16 weeks (old-ex) or to a sedentary control group (old-sed), and compared to young sedentary males (young-sed)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29587379/galectin-3-in-atrial-fibrillation-mechanisms-and-therapeutic-implications
#20
REVIEW
Nicolas Clementy, Eric Piver, Arnaud Bisson, Clémentine Andre, Anne Bernard, Bertrand Pierre, Laurent Fauchier, Dominique Babuty
Maintenance of atrial fibrillation is a complex mechanism, including extensive electrical and structural remodeling of the atria which involves progressive fibrogenesis. Galectin-3 is a biomarker of fibrosis, and, thus, may be involved in atrial remodeling in atrial fibrillation patients. We review the role of galectin-3 in AF mechanisms and its potential therapeutic implications.
March 25, 2018: International Journal of Molecular Sciences
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