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https://www.readbyqxmd.com/read/28431140/performance-of-the-patient-reported-outcomes-measurement-information-system-29-in-scleroderma-a-scleroderma-patient-centered-intervention-network-cohort-study
#1
Linda Kwakkenbos, Brett D Thombs, Dinesh Khanna, Marie-Eve Carrier, Murray Baron, Daniel E Furst, Karen Gottesman, Frank van den Hoogen, Vanessa L Malcarne, Maureen D Mayes, Luc Mouthon, Warren R Nielson, Serge Poiraudeau, Robert Riggs, Maureen Sauvé, Fredrick Wigley, Marie Hudson, Susan J Bartlett
Objective.: The Patient-Reported Outcomes Measurement Information System (PROMIS)-29 assesses seven health-related quality of life domains plus pain intensity. The objective was to examine PROMIS-29v2 validity and explore clinical associations in patients with SSc. Methods.: English-speaking SSc patients in the Scleroderma Patient-centered Intervention Network Cohort from 26 sites in Canada, the USA and the UK completed the PROMIS-29v2 between July 2014 and November 2015...
April 18, 2017: Rheumatology
https://www.readbyqxmd.com/read/28426895/short-term-pulmonary-function-trends-are-predictive-of-mortality-in-interstitial-lung-disease-associated-with-systemic-sclerosis
#2
Nicole S Goh, Rachel K Hoyles, Christopher P Denton, David M Hansell, Elisabetta A Renzoni, Toby M Maher, Andrew G Nicholson, Athol U Wells
OBJECTIVE: To determine the prognostic value of pulmonary function test (PFT) trends at one and two years in interstitial lung disease associated with systemic sclerosis (SSc-ILD). METHODS: The prognostic significance of PFT trends at one year (n=162), and two years (n=140) was examined against 15 year survival. PFT trends, expressed as continuous and categorical change in separate analyses, were examined against mortality in univariate and multivariate models. SSc-ILD was defined at presentation as limited lung fibrosis or extensive lung fibrosis using the UKRSA staging system...
April 20, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28422071/comparative-analysis-of-the-complete-chloroplast-genome-of-four-endangered-herbals-of-notopterygium
#3
Jiao Yang, Ming Yue, Chuan Niu, Xiong-Feng Ma, Zhong-Hu Li
Notopterygium H. de Boissieu (Apiaceae) is an endangered perennial herb endemic to China. A good knowledge of phylogenetic evolution and population genomics is conducive to the establishment of effective management and conservation strategies of the genus Notopterygium. In this study, the complete chloroplast (cp) genomes of four Notopterygium species (N. incisum C. C. Ting ex H. T. Chang, N. oviforme R. H. Shan, N. franchetii H. de Boissieu and N. forrestii H. Wolff) were assembled and characterized using next-generation sequencing...
April 19, 2017: Genes
https://www.readbyqxmd.com/read/28422002/treatment-of-psoriasis-with-ustekinumab-improved-skin-tightening-in-systemic-sclerosis
#4
Asako Ichihara, Masatoshi Jinnin, Hironobu Ihn
Systemic sclerosis (SSc) is a chronic autoimmune disease characterised by fibrosis, inflammation and vasculopathy in the skin and internal organs. Recently, several articles described that Th17 cells, IL-23 and IL-17 levels were significantly elevated in the peripheral blood or fibrotic sites of SSc. We report a case of SSc and psoriasis administered ustekinumab, IL-12/IL-23 inhibitor. In this case, the skin tightening was successfully improved and ustekinumab was more effective, even though oral prednisolone (9-12 mg/day) had some effect on skin tightening and arthralgia...
April 19, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28420992/deficient-adipogenesis-of-scleroderma-patient-and-healthy-african-american-monocytes
#5
Rebecca Lee, Charles Reese, Gustavo Carmen-Lopez, Beth Perry, Michael Bonner, Marina Zemskova, Carole L Wilson, Kristi L Helke, Richard M Silver, Stanley Hoffman, Elena Tourkina
Monocytes from systemic sclerosis (SSc, scleroderma) patients and healthy African Americans (AA) are deficient in the regulatory protein caveolin-1 leading to enhanced migration toward chemokines and fibrogenic differentiation. While dermal fibrosis is the hallmark of SSc, loss of subcutaneous adipose tissue is a lesser-known feature. To better understand the etiology of SSc and the predisposition of AA to SSc, we studied the adipogenic potential of SSc and healthy AA monocytes. The ability of SSc and healthy AA monocytes to differentiate into adipocyte-like cells (ALC) is inhibited compared to healthy Caucasian (C) monocytes...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28414208/highly-compressible-nitrogen-doped-carbon-foam-electrode-with-excellent-rate-capability-via-a-smart-etching-and-catalytic-process
#6
Kang Xiao, Yanhua Zeng, Jin Long, Hongbin Chen, Liangxin Ding, Suqing Wang, Haihui Wang
Freestanding three-dimensional (3D) nitrogen-doped carbon foam (NCF) with large pore architectures is proposed as a promising electrode configuration for elastic electronics. However, although it exhibits excellent mechanical performance, the available capacitive performances (especially its rate capability) are still unsatisfactory. By using KMnO4, we demonstrate a smart etching and catalytic process to form highly graphitized and etched nitrogen-doped carbon foam (denoted as ENCF) with an exfoliated carbon shell architecture...
April 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28414099/molecular-evolution-of-the-plastid-genome-during-diversification-of-the-cotton-genus
#7
Zhiwen Chen, Corrinne E Grover, Pengbo Li, Yumei Wang, Hushuai Nie, Yanpeng Zhao, Meiyan Wang, Fang Liu, Zhongli Zhou, Xingxing Wang, Xiaoyan Cai, Kunbo Wang, Jonathan F Wendel, Jinping Hua
Cotton (Gossypium spp.) is commonly grouped into eight diploid genomic groups, designated A-G and K, and one tetraploid genomic group, namely AD. To gain insight into the phylogeny of Gossypium and molecular evolution of the chloroplast genome duringdiversification, chloroplast genomes (cpDNA) from 6 D-genome and 2 G-genome species of Gossypium (G. armourianum D2-1, G. harknessii D2-2, G. davidsonii D3-d, G. klotzschianum D3-k, G. aridum D4, G. trilobum D8, and G. australe G2, G. nelsonii G3) were newly reported here...
April 13, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28413676/expression-patterns-of-cd168-correlate-with-the-stage-and-grade-of-squamous-cell-carcinoma-of-head-and-neck
#8
Korinna Jöhrens, Ioannis Anagnostopoulos, Steffen Dommerich, Jan Dirk Raguse, Agnieszka J Szczepek, Frederick Klauschen, Katharina Stölzel
The receptor for hyaluronan-mediated motility CD168 is associated with the processes of oncogenesis and metastasis. The objective of the present study was to determine the possible association between the expression and distribution of CD168 and the tumor stage of head-and-neck squamous cell carcinoma (SCC). Formalin-fixed and paraffin-embedded tumor samples obtained from 100 patients during primary resection of SCC from the oral cavity, oropharynx, hypopharynx or larynx were included in the present study. The patients were divided into two risk groups: Low risk, representing the early stage of completely resected SCCs with good-to-moderate differentiation, and the high-risk group, representing the advanced stage SCCs with positive resection margins, vascular invasion or locoregional metastasis...
April 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28412704/structural-validity-of-the-rheumatology-attitudes-index-in-systemic-sclerosis-analysis-from-the-ucla-scleroderma-quality-of-life-study
#9
Shadi Gholizadeh, Sarah D Mills, Rina S Fox, Erin L Merz, Scott C Roesch, Philip J Clements, Suzanne Kafaja, Daniel E Furst, Dinesh Khanna, Vanessa L Malcarne
OBJECTIVE: To evaluate the structural validity of the Rheumatology Attitudes Index (RAI), a widely used measure of rheumatic disease-related helplessness in patients with systemic sclerosis (SSc). METHODS: Patients with physician-confirmed SSc from the University of California, Los Angeles (UCLA) Scleroderma Quality of Life Study (n = 208) received clinical examinations and completed self-report questionnaires. The structural validity of the RAI was examined through confirmatory and exploratory factor analysis (CFA/EFA)...
April 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28412648/content-decline-of-serca-inhibitors-saikosaponin-a-and-d-attenuates-cardiotoxicity-and-hepatotoxicity-of-vinegar-baked-radix-bupleuri
#10
Shifeng Wang, Yuxin Zhang, Qiao Zhang, Sha Peng, Chen Shen, Yangyang Yu, Minyu Zhang, Wei Yang, Qinghua Wu, Yanling Zhang, Shiyou Li, Yanjiang Qiao
Improper usage of unprocessed Radix bupleuri root (chaihu) may cause cardiotoxicity and liver injury. Baking herb with vinegar is believed to attenuate the adverse responses. However, the chemical and molecular basis involved remained unclear. To this end, we investigated the in vitro toxicity of saikosaponin a, c, d, and their hydrolysates saikosaponin b1 and b2. Results showed that SSa and SSd possessed higher affinity with sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) by molecular docking, and exhibited stronger toxic responses on cardiomyocytes and hepatocytes than the other three saikosaponins in equivalent concentrations...
April 4, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28411133/clinical-significance-of-fibromyalgia-syndrome-in-different-rheumatic-diseases-relation-to-disease-activity-and-quality-of-life
#11
Sarah El-Rabbat M, Nermeen K Mahmoud, Tamer A Gheita
OBJECTIVE: To describe the frequencies of fibromyalgia syndrome (FMS) in various rheumatic diseases; rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis (SSc) and Behçets disease (BD) patients and to study the relation to clinical manifestations and quality of life (QoL). PATIENTS AND METHODS: 160 patients (50 RA, 50 SLE, 30 SSc and 30 BD) and matched corresponding healthy controls were included. Disease activity was assessed using disease activity score in 28 joints (DAS28) for RA, SLE Disease Activity index (SLEDAI), modified Rodnan skin score for SSc and BD Current Activity Form (BDCAF)...
April 11, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28408750/transcriptional-regulatory-networks-underlying-the-reprogramming-of-spermatogonial-stem-cells-to-multipotent-stem-cells
#12
Hoe-Su Jeong, Jinhyuk Bhin, Hyung Joon Kim, Daehee Hwang, Dong Ryul Lee, Kye-Seong Kim
Spermatogonial stem cells (SSCs) are germline stem cells located along the basement membrane of seminiferous tubules in testes. Recently, SSCs were shown to be reprogrammed into multipotent SSCs (mSSCs). However, both the key factors and biological networks underlying this reprogramming remain elusive. Here, we present transcriptional regulatory networks (TRNs) that control cellular processes related to the SSC-to-mSSC reprogramming. Previously, we established intermediate SSCs (iSSCs) undergoing the transition to mSSCs and generated gene expression profiles of SSCs, iSSCs and mSSCs...
April 14, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28408277/lung-transplantation-in-systemic-sclerosis-a-single-center-cohort-study
#13
Andreu Fernández-Codina, Cristina Berastegui, Iago Pinal-Fernández, María Guadalupe Silveira, Manuel López-Meseguer, Víctor Monforte, Alfredo Guillén-Del Castillo, Carmen Pilar Simeón-Aznar, Vicent Fonollosa-Plà, Joan Solé, Carlos Bravo-Masgoret, Antonio Román-Broto
OBJECTIVE: Lung transplantation (LT) has been proposed as a treatment for advanced Interstitial Lung Disease (ILD) and/or Pulmonary Hypertension (PH) associated to Systemic Sclerosis (SSc) but few studies have been reported. The aim of this study was to describe the clinical features, complications and survival of a single-center cohort of patients with SSc that underwent LT and to compare their survival with a group of non-SSc transplanted patients. METHODS: Fifteen patients with SSc were transplanted between May 2005 and April 2015...
April 10, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28407907/the-effects-of-postharvest-application-of-lecithin-to-improve-storage-potential-and-quality-of-fresh-goji-lycium-barbarum-l-berries
#14
Mushtaque Ahmed Jatoi, Slaven Jurić, Rajko Vidrih, Marko Vinceković, Marko Vuković, Tomislav Jemrić
To enhance storage life and post-storage quality of fresh goji berries, three treatments with lecithin (1, 5, 10g·L(-1)) and two storage times (8, 16days) were evaluated. The significant effects on the physiological and biochemical parameters were varied. 1g·L(-1) lecithin showed its main effects after 8days of storage by reduction in total weight loss and decay, SSC/TA ratio (also at 16days), and chlorophyll content and with highest scores of sensory attributes (also at 16days). 5g·L(-1) lecithin showed its main effects after 16days of storage: highest SSC, highest TA (also at 8days), highest TPC, only significant reduction in DPPH antioxidant activity, and highest total flavonoid content...
September 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28407476/measurement-of-sodium-concentration-in-sweat-samples-comparison-of-five-analytical-techniques
#15
Eric D B Goulet, Audrey Asselin, Jonathan Gosselin, Lindsay B Baker
PURPOSE: Sweat sodium concentration (SSC) can be determined using different analytical techniques (ATs), which may have implications for athletes and scientists. This study compared the SSC measured with five ATs: ion chromatography (IChr), flame photometry (FP), direct (DISE) and indirect (IISE) ion selective electrode and ion conductivity (IC). METHODS: Seventy sweat samples collected from 14 athletes were analyzed with 5 instruments: the 883 Basic IC Plus (IChr, reference instrument), AAnalyst 200 (FP), Cobas 6000 (IISE), Sweat-Chek (IC) and B-722 Laqua Twin (DISE)...
April 13, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28404628/simultaneous-detection-of-decidual-th1-th2-and-nk1-nk2-immunophenotyping-in-unknown-recurrent-miscarriage-using-8-color-flow-cytometry-with-fsc-vt-extended-strategy
#16
Peng Dong, Xi Wen, Jia Liu, Cui-Yan Yan, Jing Yuan, Lan-Rong Luo, Qiao-Fei Hu, Jian Li
Th1/Th2 imbalance is considered as a mechanism of recurrent miscarriage. The NK1/NK2 paradigm is hypothesized to play an important role in pregnancy. However, few results showed simultaneous changes of these subsets in vivo in decidual tissues. This study aimed to detect the decidual mononuclear cells and the Th1/Th2 and NK1/NK2 paradigm simultaneously using multiparametric flow cytometry (MFC) in unexplained recurrent miscarriages (URM). Mononuclear cells were isolated from the decidual tissues of URM cases and early pregnant women...
April 12, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28402008/genome-wide-association-studies-reveal-additional-related-loci-for-fatty-acid-composition-in-a-duroc-pig-multigenerational-population
#17
Shuji Sato, Yoshinobu Uemoto, Takashi Kikuchi, Sachiko Egawa, Kimiko Kohira, Tomomi Saito, Hironori Sakuma, Satoshi Miyashita, Shinji Arata, Keiichi Suzuki
The aim of the present study was to detect quantitative trait loci affecting fatty acid composition in back fat and intramuscular fat in a Duroc pig population comprising seventh-generation pedigrees using genome-wide association studies (GWAS). In total, 305 animals were genotyped using single nucleotide polymorphisms (SNPs) array and five selected SNPs from regions containing known candidate genes related to fatty acid synthesis or metabolism. In total, 24 genome-wide significant SNP regions were detected in 12 traits, and 76 genome-wide suggestive SNP regions were detected in 33 traits...
April 12, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28400867/evaluation-of-autoantibodies-in-patients-with-primary-and-secondary-sjogren-s-syndrome
#18
Ellen De Langhe, Xavier Bossuyt, Long Shen, Kishore Malyavantham, Julian L Ambrus, Lakshmanan Suresh
BACKGROUND: Antibodies to salivary gland protein 1 (SP1), carbonic anhydrase 6 (CA6) and parotid secretory protein (PSP) were discovered in an animal model of Sjogren's syndrome (SS). Their expression was noted in patients with SS, especially those with lower focus scores on lip biopsies and those with early disease lacking antibodies to Ro and La. OBJECTIVE: The current studies evaluated these autoantibodies in patients with long-standing SS expressing high levels of anti-Ro antibodies and in patients with Sjogren's syndrome secondary to systemic lupus erythematosus (SLE), systemic sclerosis (SSc) and mixed connective tissue disease (MCTD)...
2017: Open Rheumatology Journal
https://www.readbyqxmd.com/read/28400270/differential-expression-profile-of-mirnas-in-porcine-muscle-and-adipose-tissue-during-development
#19
Qi Wang, Renli Qi, Jing Wang, Wenming Huang, Yongjiang Wu, Huang Xiaofeng, Feiyun Yang, Jinxiu Huang
MicroRNAs (miRNAs) are a class of non-coding RNAs that play a crucial regulatory role in many biological processes. Previous studies have reported miRNAs that are associated with the growth, differentiation, and proliferation of myocytes and adipocytes in pigs. However, differences in the miRNA expression profiles between muscle and adipose tissues during porcine development are unknown. Muscle and adipose tissues are the two major organs that are crucial for dynamic energy balance in the development and metabolism...
April 8, 2017: Gene
https://www.readbyqxmd.com/read/28399523/sperm-sediment-cytology-a-new-technique-for-diagnosing-occult-urologic-infections
#20
Zhanna Sapozhkova, Karina Kasoyan, Elena Kovalchuk, Irina Shabalova
BACKGROUND: Ill-defined chronic symptoms such as itching, burning, urethral discharge, and pelvic pain are not uncommon in male urologic patients. Often, microscopic urinalysis, bacterial cultures, and laboratory testing are non-contributory. We have developed a technique for sperm sedimentation and used the cytologic examination of the sediment routinely in more than 4,000 patients with urologic complaints over the last 5 years. CASE: We present 3 exemplary cases, documenting the diagnostic power of sperm sediment cytology (SSC)...
April 12, 2017: Acta Cytologica
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