keyword
MENU ▼
Read by QxMD icon Read
search

Ssc

keyword
https://www.readbyqxmd.com/read/29149923/gastrointestinal-and-hepatic-disease-in-systemic-sclerosis
#1
REVIEW
Tracy M Frech, Diane Mar
Although classification criteria for systemic sclerosis (SSc) do not incorporate gastrointestinal tract (GIT) manifestations often present in this disease, the GIT is the most common internal organ involved. Pathophysiology of GIT involvement is thought to be similar to other organs in SSc with fibroproliferative vascular lesions of small arteries and arterioles, increased production of profibrotic growth factors, and alterations of innate, humoral, and cellular immunity. These processes result in neuropathy progressing to myopathy with eventual fibrosis...
February 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29149505/an-international-continence-society-ics-report-on-the-terminology-for-adult-neurogenic-lower-urinary-tract-dysfunction-anlutd
#2
Jerzy B Gajewski, Brigitte Schurch, Rizwan Hamid, Márcio Averbeck, Ryuji Sakakibara, Enrico F Agrò, Tamara Dickinson, Christopher K Payne, Marcus J Drake, Bernie T Haylen
INTRODUCTION: The terminology for adult neurogenic lower urinary tract dysfunction (ANLUTD) should be defined and organized in a clinically based consensus Report. METHODS: This Report has been created by a Working Group under the auspices and guidelines of the International Continence Society (ICS) Standardization Steering Committee (SSC) assisted at intervals by external referees. All relevant definitions for ANLUTD were updated on the basis of research over the last 14 years...
November 17, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29149196/easy-xeno-free-and-feeder-free-method-for-isolating-and-growing-limbal-stromal-and-epithelial-stem-cells-of-the-human-cornea
#3
Djida Ghoubay-Benallaoua, Céline de Sousa, Raphaël Martos, Gaël Latour, Marie-Claire Schanne-Klein, Elisabeth Dupin, Vincent Borderie
Epithelial and stromal stem cells are required to maintain corneal transparency. The aim of the study was to develop a new method to isolate and grow both corneal stromal (SSC) and epithelial limbal (LSC) stem cells from small human limbal biopsies under culture conditions in accordance with safety requirements mandatory for clinical use in humans. Superficial limbal explants were retrieved from human donor corneo-scleral rims. Human limbal cells were dissociated by digestion with collagenase A, either after epithelial scraping or with no scraping...
2017: PloS One
https://www.readbyqxmd.com/read/29147913/expression-of-tlr7-tlr9-jak2-and-stat3-genes-in-peripheral-blood-mononuclear-cells-from-patients-with-systemic-sclerosis
#4
Miša Vreća, Ana Zeković, Nemanja Damjanov, Marina Andjelković, Milena Ugrin, Sonja Pavlović, Vesna Spasovski
Systemic sclerosis (SSc) is a rare, chronic, multisystem autoimmune disease clinically characterized by progressive fibrosis of the skin and internal organs. The basic mechanism appears to involve endothelial cell injury, overproduction of extracellular matrix proteins, and aberrant immune activation. So far, there have been a few attempts to find genetic biomarkers for monitoring disease activity or for correlation with certain symptoms. In order to reveal reliable biomarkers, we analyzed the expression of four genes representing three important signaling pathways, TLR7, TLR9, and JAK2-STAT3...
November 16, 2017: Journal of Applied Genetics
https://www.readbyqxmd.com/read/29143989/nanos2-promotes-differentiation-of-chicken-gallus-gallus-embryonic-stem-cells-to-male-germ-cells
#5
Zhang Wenhui, Bi Yulin, Wang Yingjie, Li Dong, He Nana, Wang Man, Jin Jing, Zuo Qisheng, Zhang Yani, Li Bichun
Nanos2 is an evolutionarily conserved RNA-binding protein containing 2 CCHC-type zinc finger motives. Here, we report that Nanos2 is strongly expressed in the testis compared to other tissues in chicken (Gallus gallus). Overexpression and knockout plasmid vectors were constructed, and in-vitro Cas9/gRNA digestion and T7 endonuclease I (T7E1) assay indicated that Nanos2-g1 possessed the highest knockout activity. In vitro and in vivo, Nanos2 overexpression accelerated the production of embryoid bodies (EBs) and SSC-like cells and promoted cvh, c-kit and integrin α6 expression...
November 16, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29143880/effects-of-heat-waves-on-daily-excess-mortality-in-14-korean-cities-during-the-past-20%C3%A2-years-1991-2010-an-application-of-the-spatial-synoptic-classification-approach
#6
Dae-Geun Lee, Kyu Rang Kim, Jiyoung Kim, Baek-Jo Kim, Chun-Ho Cho, Scott C Sheridan, Laurence S Kalkstein, Ho Kim, Seung-Muk Yi
The aims of this study are to explore the "offensive" summer weather types classified under the spatial synoptic classification (SSC) system and to evaluate their impacts on excess mortality in 14 Korean cities. All-cause deaths per day for the entire population were examined over the summer months (May-September) of 1991-2010. Daily deaths were standardized to account for long-term trends of subcycles (annual, seasonal, and weekly) at the mid-latitudes. In addition, a mortality prediction model was constructed through multiple stepwise regression to develop a heat-health warning system based on synoptic climatology...
November 16, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/29142074/stat3-controls-col1a2-enhancer-activation-cooperatively-with-junb-regulates-type-i-collagen-synthesis-post-transcriptionally-and-is-essential-for-lung-myofibroblast-differentiation
#7
Ioannis Papaioannou, Shiwen Xu, Christopher P Denton, David J Abraham, Markella Ponticos
Fibroblast differentiation is key cellular process that underlies the process of fibrosis, a deadly complication of fibrotic diseases like Scleroderma (SSc). This transition coincides with the overproduction of Collagen type I (COL1) and other extracellular matrix proteins. High level expression of the collagen type 1α2 subunit (COL1A2), requires the engagement of a far upstream enhancer, whose activation is strongly dependent on the AP1 factor JunB. We now report that STAT3 also binds the COL1A2 enhancer and is essential for RNA polymerase recruitment, without affecting JunB binding...
November 15, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29142033/all-cause-healthcare-costs-and-mortality-in-patients-with-systemic-sclerosis-with-lung-involvement
#8
Aryeh Fischer, Amanda M Kong, Jeffrey J Swigris, Ashley L Cole, Karina Raimundo
OBJECTIVE: Patients with systemic sclerosis (SSc) often develop interstitial lung disease (ILD) and/or pulmonary arterial hypertension (PAH). The effect of ILD and PAH on healthcare costs among patients with SSc is not well described. The objective of this analysis was to describe healthcare costs in patients with newly diagnosed SSc and SSc patients newly diagnosed with ILD and/or PAH in the United States. METHODS: This retrospective cohort analysis was conducted in the Truven Health MarketScan Commercial and Medicare Supplemental healthcare claims databases from 2003 to 2014...
November 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29142028/high-baseline-serum-clara-cell-16-kda-predicts-subsequent-lung-disease-worsening-in-systemic-sclerosis
#9
Sébastien Rivière, Thong Hua-Huy, Kiet Phong Tiev, Jean Cabane, Anh Tuan Dinh-Xuan
OBJECTIVE: Clara cell secretory protein (CC16) is a sensitive marker of bronchial epithelial cell damage. The CC16 serum level is elevated in patients with pulmonary fibrosis, but its predictive value on lung disease progression has not yet been studied. We aimed to assess the value of serum CC16 concentration in predicting lung disease deterioration in patients with systemic sclerosis (SSc). METHODS: We prospectively analyzed and followed 106 patients with SSc during a 4-year period for the risk of developing combined deleterious event, defined as a 10% decrease in total lung capacity or forced vital capacity from baseline, or death, according to serum CC16 at inclusion...
November 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29140474/identification-of-novel-systemic-sclerosis-biomarkers-employing-aptamer-proteomic-analysis
#10
Peter J Wermuth, Sonsoles Piera-Velazquez, Sergio A Jimenez
There is an important unmet need for clinically validated non-invasive biomarkers for SSc diagnosis, assessment of disease activity, extent of internal organ involvement, therapeutic response and prognosis. There is also an unmet need for biomarkers to accurately differentiate primary RP from recent onset RP evolving into SSc. The lack of sensitive and specific biomarkers for SSc and SSc-associated RP is a limitation for the optimal clinical management of these patients. The development of highly sensitive and specific proteomic analysis employing aptamers and the expansion in the number of proteins that can be specifically identified by aptamer proteomics have opened new horizons for biomarker discovery...
November 13, 2017: Rheumatology
https://www.readbyqxmd.com/read/29138689/clarifying-sub-genomic-positions-of-qtls-for-flowering-habit-and-fruit-quality-in-u-s-strawberry-fragaria%C3%A3-ananassa-breeding-populations-using-pedigree-based-qtl-analysis
#11
Sujeet Verma, Jason D Zurn, Natalia Salinas, Megan M Mathey, Beatrice Denoyes, James F Hancock, Chad E Finn, Nahla V Bassil, Vance M Whitaker
The cultivated strawberry (Fragaria×ananassa) is consumed worldwide for its flavor and nutritional benefits. Genetic analysis of commercially important traits in strawberry are important for the development of breeding methods and tools for this species. Although several quantitative trait loci (QTL) have been previously detected for fruit quality and flowering traits using low-density genetic maps, clarity on the sub-genomic locations of these QTLs was missing. Recent discoveries in allo-octoploid strawberry genomics led to the development of the IStraw90 single-nucleotide polymorphism (SNP) array, enabling high-density genetic maps and finer resolution QTL analysis...
2017: Horticulture Research
https://www.readbyqxmd.com/read/29138534/vitamin-d-levels-in-systemic-sclerosis-patients-a-meta-analysis
#12
REVIEW
Lin An, Ming-Hui Sun, Feng Chen, Jin-Ran Li
Purpose: This study aimed to investigate the association between vitamin D and systemic sclerosis (SSc) by meta-analysis. Methods: A comprehensive search was performed through June 12, 2017. Pooled standardized mean difference (SMD) was used to estimate the mean vitamin D difference between case and control groups (or between diffused- and limited-type SSc). Pooled risk ratios (RRs) with 95% confidence intervals (CIs) were used to assess the impact of vitamin D level on clinical characteristics of SSc patients...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29134154/a-comparison-of-chloroplast-genome-sequences-in-aconitum-ranunculaceae-a-traditional-herbal-medicinal-genus
#13
Hanghui Kong, Wanzhen Liu, Gang Yao, Wei Gong
The herbal medicinal genus Aconitum L., belonging to the Ranunculaceae family, represents the earliest diverging lineage within the eudicots. It currently comprises of two subgenera, A. subgenus Lycoctonum and A. subg. Aconitum. The complete chloroplast (cp) genome sequences were characterized in three species: A. angustius, A. finetianum, and A. sinomontanum in subg. Lycoctonum and compared to other Aconitum species to clarify their phylogenetic relationship and provide molecular information for utilization of Aconitum species particularly in Eastern Asia...
2017: PeerJ
https://www.readbyqxmd.com/read/29131378/physiological-benefits-to-parents-from-undertaking-skin-to-skin-contact-with-their-neonate-in-a-neonatal-intensive-special-care-unit
#14
Hannah Jones, Nick Santamaria
There has been increased focus on the use of family-centred care interventions, such as skin-to-skin contact (SSC) in Neonatal Intensive Special Care (NISC) Units over the past two decades. SSC between a parent and their neonate has previously shown to promote positive mental and emotional health in parents and assist in bonding and attachment between parent and neonate. The purpose of this study was to investigate the effect that SSC between parent and their neonate has on the parent's heart rate (HR) and blood pressure (BP)...
November 13, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/29131296/complete-percutaneous-approach-versus-surgical-access-in-transfemoral-transcatheter-aortic-valve-implantation-results-from-a-multicenter-registry
#15
Janusz Kochman, Łukasz Kołtowski, Zenon Huczek, Bartosz Rymuza, Radosław Wilimski, Maciej Dąbrowski, Adam Witkowski, Marek Grygier, Anna Olasińska-Wiśniewska, Piotr Kubler, Krzysztof Reczuch, Radosław Parma, Andrzej Ochała, Dariusz Jagielak, Wacław Kochman, Eberhard Grube
BACKGROUND: Although the femoral approach is the most common route utilized in transcatheter aortic valve implantation (TAVI) it still carries a substantial risk of severe bleeding and vascular complications. The aim of our study was to compare the safety and efficacy of the complete percutaneous (CPC) approach with surgical cutdown and closure (SCC) in TAVI patients. METHODS: The study population comprised 683 patients with severe aortic stenosis who underwent transfemoral TAVI...
November 13, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/29130325/the-plasma-levels-of-adamts-13-von-willebrand-factor-vwfpp-and-fibrin-related-markers-in-patients-with-systemic-sclerosis-having-thrombosis
#16
Koji Habe, Hideo Wada, Ayaka Higashiyama, Tomoko Akeda, Kenshiro Tsuda, Ryoko Mori, Masato Kakeda, Takeshi Matsumoto, Kohshi Ohishi, Keiichi Yamanaka, Naoyuki Katayama, Hitoshi Mizutani
This study aimed to examine the hemostatic abnormalities in patients with systemic sclerosis (SSc) and the relationship between these abnormalities and thrombotic events (THEs), focusing on the difference in diffuse cutaneous SSc (dcSSc) and limited cutaneous SSc (lcSSc). The plasma levels of ADAMTS-13 (a disintegrin-like and metalloproteinase with thrombospondin type 1 motifs 13), von Willebrand factor (VWF), VWF propeptide (VWFpp), d-dimer, and soluble fibrin (SF) were measured in 233 patients with SSc. The relationship between their levels and organ involvement, including THEs and interstitial lung disease (ILD), was evaluated...
January 1, 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29129363/decreasing-intraoperative-delays-with-meaningful-use-of-the-surgical-safety-checklist
#17
K Tinsley Anderson, Marisa A Bartz-Kurycki, Kendall M Masada, Jocelyn E Abraham, Jiasen Wang, Akemi L Kawaguchi, Mary T Austin, Lillian S Kao, Kevin P Lally, KuoJen Tsao
BACKGROUND: Purposeful completion (fidelity) more than simple adherence to items in the surgical safety checklist may improve operating room efficiency and patient safety. The purpose of this study was to evaluate intraoperative delays and correlate them with adherence and fidelity to the preincision surgical safety checklist. METHODS: Trained observers evaluated surgical safety checklist compliance during 3 observation periods from 2014-2016. Degree of adherence, checkpoint verbalization, fidelity, and meaningful completion were assessed...
November 9, 2017: Surgery
https://www.readbyqxmd.com/read/29127442/increased-frequencies-of-circulating-cxcl10-cxcl8-and-ccl4-producing-monocytes-and-siglec-3-expressing-myeloid-dendritic-cells-in-systemic-sclerosis-patients
#18
Tiago Carvalheiro, Sara Horta, Joel A G van Roon, Mariana Santiago, Maria J Salvador, Hélder Trindade, Timothy R D J Radstake, José A P da Silva, Artur Paiva
OBJECTIVE: To investigate the ex vivo pro-inflammatory properties of classical and non-classical monocytes as well as myeloid dendritic cells (mDCs) in systemic sclerosis (SSc) patients. METHODS: Spontaneous production of CXCL10, CCL4, CXCL8 and IL-6 was intracellularly evaluated in classical, non-classical monocytes and Siglec-3-expressing mDCs from peripheral blood of SSc patients and healthy controls (HC) through flow cytometry. In addition, production of these cytokines was determined upon toll-like receptor (TLR) 4 plus Interferon-γ (IFN-γ) stimulation...
November 10, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29126878/dendritic-cells-in-systemic-sclerosis-advances-from-human-and-mice-studies
#19
REVIEW
Alsya J Affandi, Tiago Carvalheiro, Timothy R D J Radstake, Wioleta Marut
Systemic sclerosis (SSc) is a complex heterogeneous fibrotic autoimmune disease with an unknown exact etiology, and characterized by three hallmarks: fibrosis, vasculopathy, and immune dysfunction. Dendritic cells (DCs) are specialized cells in pathogen sensing with high potency of antigen presentation and capable of releasing mediators to shape the immune response. Altered DCs distributions and their impaired functions may account for their role in breaking the immune tolerance and driving inflammation in SSc, and the direct contribution of DCs in promoting endothelial dysfunction and fibrotic process has only begun to be understood...
November 7, 2017: Immunology Letters
https://www.readbyqxmd.com/read/29126717/2013-acr-eular-systemic-sclerosis-classification-criteria-in-patients-with-associated-pulmonary-arterial-hypertension
#20
Beatriz E Joven, Pilar Escribano, Jose Luis Andreu, Estibaliz Loza, Carmen Jimenez, M Jesus Garcia de Yebenes, M Jose Ruiz-Cano, Loreto Carmona, Patricia E Carreira
OBJECTIVE: To analyze the performance of the 1980 ACR and new 2013 ACR/EULAR criteria for systemic sclerosis (SSc) in cutaneous SSc (lcSSc) patients, especially those affected by lcSSc and pulmonary arterial hypertension (PAH). METHODS: All patients with a clinical lcSSc diagnosis from a prospective observational SSc cohort were included. Sociodemographic and disease-related variables were collected, and PAH confirmed by right heart catheterization (RHC). Performance of the 2013 and 1980 SSc criteria was analyzed in terms of clinical diagnosis...
October 13, 2017: Seminars in Arthritis and Rheumatism
keyword
keyword
7456
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"