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https://www.readbyqxmd.com/read/28643541/effects-of-ph-and-concentration-of-sodium-citrate-anticoagulant-on-platelet-aggregation-measured-by-light-transmission-aggregometry-induced-by-adenosine-diphosphate
#1
Ksenia Germanovich, Eti Alessandra Femia, Chun Yan Cheng, Natalia Dovlatova, Marco Cattaneo
The 2013 ISTH-SSC guidelines for the standardization of light transmission aggregometry (LTA) were largely based on expert consensus, as studies directly comparing LTA methodologies were lacking. We experimentally tested the cogency of ISTH-SSC recommendations pertaining to use of anticoagulant, in particular whether: (1) buffered citrate (BC) is preferable to unbuffered citrate (C); (2) the two recommended concentrations of sodium citrate (109 and 129 mM) are equivalent in terms of platelet aggregation (PA)...
June 23, 2017: Platelets
https://www.readbyqxmd.com/read/28641551/nailfold-capillaroscopy-within-and-beyond-the-scope-of-connective-tissue-diseases
#2
Sevdalina Lambova, Ulf Müller-Ladner
Nailfold capillaroscopy is a noninvasive instrumental method for morphological analysis of the nutritive capillaries in the nailfold area. In rheumatology, it is a method of choice among instrumental modalities for differentiation of primary and secondary Raynaud's phenomenon (RP) in rheumatic diseases. RP is a common diagnostic problem in rheumatology. Defining the proper diagnosis is a prerequisite for administration of the appropriate treatment. Thus, nailfold capillaroscopic examination is of crucial importance for the every-day practice of the rheumatologists and is currently gaining increasing attention...
June 14, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28640077/improvement-of-peripheral-artery-disease-with-sildenafil-and-bosentan-combined-therapy-in-a-patient-with-limited-cutaneous-systemic-sclerosis-a-case-report
#3
Loukman Omarjee, Cedric Fontaine, Guillaume Mahe, Vincent Jaquinandi
RATIONALE: Sildenafil, a phosphodiesterase-5-inhibitor and Bosentan, an endothelin-1-receptor antagonist combined therapy could have beneficial effect in systemic sclerosis (SSc) patients with peripheral artery disease. PATIENT CONCERNS: We report a case of a 48-year-old Black woman, who developed severe left limb claudication and walking limitation following a left femoropopliteal bypass occlusion in 2014. She was a heavy smoker and had a history of right middle cerebral artery ischemic stroke and bilateral Raynaud phenomenon...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28639412/the-role-of-microrna-5196-in-the-pathogenesis-of-systemic-sclerosis
#4
Marzena Ciechomska, Patryk Zarecki, Michal Merdas, Jerzy Swierkot, Ewa Morgiel, Piotr Wiland, Wlodzimierz Maslinski, Katarzyna Bogunia-Kubik
BACKGROUND: Systemic sclerosis (SSc) is a chronic autoimmune disease characterised by tissue fibrosis and immune abnormalities. Recent evidence suggests that activated circulating monocytes from SSc patients play an important role in early stages of SSc pathogenesis due to enhanced expression of tissue inhibitor of metalloproteinases 1 (TIMP-1), IL-8 and reactive oxygen species (ROS) induction. However, the exact factors that contribute to chronic inflammation and subsequently fibrosis progression are still unknown...
June 21, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28634390/increased-glutamate-in-somatosensory-cortex-in-functional-dyspepsia
#5
Arthur D P Mak, Georg Northoff, David K W Yeung, Winnie C W Chu, Steve C N Hui, Cynthia Cheung, Jessica Ching, Linda Lam, Sing Lee, Justin Wu
Functional Dyspepsia-Post-prandial Distress Syndrome (FD-PDS) was associated with mood-related increases in resting activity and lowered activation threshold in the somatosensory cortex (SSC), insula and perigenual anterior cingulate cortex(pgACC) in functional imaging studies. The underlying cortical neurochemical changes are unknown. We performed proton Magnetic Resonance Spectroscopy (1H-MRS) on 17 consecutive tertiary clinic-recruited psychotropic-naïve Rome III FD-PDS female and 17 age-sex matched healthy controls...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28633671/preliminary-safety-and-efficacy-profile-of-prucalopride-in-the-treatment-of-systemic-sclerosis-ssc-related-intestinal-involvement-results-from-the-open-label-cross-over-progass-study
#6
Barbara Vigone, Monica Caronni, Adriana Severino, Chiara Bellocchi, Anna Rita Baldassarri, Mirella Fraquelli, Gaia Montanelli, Alessandro Santaniello, Lorenzo Beretta
BACKGROUND: Prokinetics are used to treat enteric dismotility symptoms in systemic sclerosis (SSc) patients, but they often lack adequate efficacy. The most effective prokinetics belonging to the serotonin (5-HT4) receptor agonists class were withdrawn due to cardiac toxicity in relation to modest 5-HT4 receptor affinity. Prucalopride is a high-affinity 5-HT4 receptor agonist with no major cardiac issues, for which the efficacy in SSc has not yet been assessed. METHODS: Forty patients with self-reported mild to moderately severe enteric symptoms were enrolled in a cross-over 2 × 2 study...
June 20, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28631694/-the-influence-of-stat4-rs7574865-g-t-polymorphism-on-the-risk-of-clinical-and-immunological-phenotypes-of-systemic-sclerosis-in-a-russian-patient-population-results-of-a-pilot-study
#7
M Yu Krylov, L P Ananyeva, О А Koneva, M N Starovoytova, O V Desinova, O B Ovsyannikova, E N Aleksandrova, A A Novikov, I A Guseva, N V Konovalova, D A Varlamov
AIM: To examine the association of signal transducer and activator transcription 4 (STAT4) rs7574865 G/T polymorphism with a predisposition to systemic sclerosis (SSC) and associated clinical and autoimmune phenotypes in a Russian population. SUBJECTS AND METHODS: A total of 102 patients with SSC and 103 healthy individuals as controls were examined. STAT4 rs7574865 polymorphism was investigated by real-time polymerase chain reaction. RESULTS: The carriers of the T allele showed a statistically significant association with SSC, a diffuse form (DF), the presence of interstitial lung disease (ILD), cardiac injury (CI), and seropositivity for anti-topoisomerase I antibodies (ATA)...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28630308/measuring-shared-variants-in-cohorts-of-discordant-siblings-with-applications-to-autism
#8
Kenny Ye, Ivan Iossifov, Dan Levy, Boris Yamrom, Andreas Buja, Abba M Krieger, Michael Wigler
We develop a method of analysis [affected to discordant sibling pairs (A2DS)] that tests if shared variants contribute to a disorder. Using a standard measure of genetic relation, test individuals are compared with a cohort of discordant sibling pairs (CDS) to derive a comparative similarity score. We ask if a test individual is more similar to an unrelated affected than to the unrelated unaffected sibling from the CDS and then, sum over such individuals and pairs. Statistical significance is judged by randomly permuting the affected status in the CDS...
June 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28628838/validated-uplc-ms-ms-method-for-simultaneous-quantification-of-eight-saikosaponins-in-rat-plasma-application-to-a-comparative-pharmacokinetic-study-in-depression-rats-after-oral-administration-of-extracts-of-raw-and-vinegar-baked-bupleuri-radix
#9
Tianli Lei, Dandan Zhang, Kun Guo, Mingxiao Li, Chongning Lv, Jing Wang, Lingyun Jia, Jincai Lu
A sensitive and efficient UPLC-MS/MS method was developed and validated for simultaneous quantification of eight saikosaponins (SSa, SSb1, SSb2, SSb3, SSb4, SSc, SSd and SSf) in rat plasma. Furthermore, comparative pharmacokinetic profiles of these sakosaponins were investigated, following oral administration of extracts of raw and vinegar-baked Bupleuri Radix to depression rats. Biosamples were processed with liquid-liquid extraction technique using ethyl acetate. Chromatographic separation was accomplished on Waters BEH C18 UPLC column...
June 16, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28627985/diagnostic-performance-of-reformatted-isotropic-thin-section-helical-ct-images-in-the-detection-of-superior-semicircular-canal-dehiscence
#10
Gianvincenzo Sparacia, Alberto Iaia
Purpose The purpose of this article is to assess the diagnostic performance of computed tomography (CT) reformatted images for detection of superior semicircular canal (SSC) dehiscence. Material and methods Forty-two patients, with sound- and/or pressure-induced vestibular symptoms, and 42 control participants underwent helical CT examination with a highly collimated beam (0.5 mm). Reformatted images of the vestibular labyrinth were obtained in the standard axial and coronal planes (group A images), and in a plane parallel and perpendicular to the SSC (group B images)...
June 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28626184/a-16-year-follow-up-case-of-interstitial-pneumonia-with-systemic-sclerosis-rheumatoid-arthritis-overlap-syndrome
#11
Hideaki Yamakawa, Eri Hagiwara, Yumie Yamanaka, Satoshi Ikeda, Akimasa Sekine, Hideya Kitamura, Tomohisa Baba, Koji Okudela, Tae Iwasawa, Tamiko Takemura, Takashi Ogura
Interstitial pneumonia is a common and major comorbidity affecting the prognosis of patients with systemic sclerosis (SSc). However, there are few reported cases of SSc-rheumatoid arthritis (RA) overlap-associated interstitial pneumonia. We herein report a case in which the clinical behavior and histopathology of interstitial pneumonia with SSc-RA overlap syndrome was followed over a long clinical course. When clinicians are deciding on the treatment strategy for patients with SSc-RA overlap syndrome-associated interstitial pneumonia, a pathological examination of a surgical lung biopsy may be useful...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28624768/a-revised-asingle-model-to-explain-stem-cell-dynamics-in-the-mouse-male-germline
#12
REVIEW
Tessa Lord, Jon M Oatley
Spermatogonial stem cells (SSCs) and progenitor spermatogonia encompass the undifferentiated spermatogonial pool in mammalian testes. In rodents, this population is comprised of Asingle, Apaired and chains of 4-16 Aaligned spermatogonia. Although traditional models propose that the entire Asingle pool represents SSCs, and formation of an Apaired syncytium symbolizes irreversible entry to a progenitor state destined for differentiation; recent models have emerged that suggest that the Asingle pool is heterogeneous, and Apaired/Aaligned can fragment to produce new SSCs...
August 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28624173/high-resolution-manometry-compared-with-the-university-of-california-los-angeles-scleroderma-clinical-trials-consortium-git-2-0-in-systemic-sclerosis
#13
Hanan Sayed M Abozaid, Hala M K Imam, Marwa Mahmoud Abdelaziz, Dina H El-Hammady, Nihal A Fathi, Daniel E Furst
OBJECTIVES: To study esophageal high resolution manometry (HRM) in systemic sclerosis (SSc) patients and the correlation of findings to The University of California, Los Angeles Scleroderma Clinical Trials Consortium gastrointestinal tract 2.0 (UCLA SCTC_GIT 2.0). METHODS: Forty SSc patients were administered to the UCLA SCTC GIT 2.0. Patients underwent HRM study (Solar GI MMS). HRM data were compared with 15 healthy volunteers. RESULTS: Forty patients with mean age 46 ± 7 years and disease duration 9...
May 19, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28623945/mir-155-is-overexpressed-in-systemic-sclerosis-fibroblasts-and-is-required-for-nlrp3-inflammasome-mediated-collagen-synthesis-during-fibrosis
#14
Carol M Artlett, Sihem Sassi-Gaha, Jennifer L Hope, Carol A Feghali-Bostwick, Peter D Katsikis
BACKGROUND: Despite the important role that microRNAs (miRNAs) play in immunity and inflammation, their involvement in systemic sclerosis (SSc) remains poorly characterized. miRNA-155 (miR-155) plays a role in pulmonary fibrosis and its expression can be induced with interleukin (IL)-1β. SSc fibroblasts have activated inflammasomes that are integrally involved in mediating the myofibroblast phenotype. In light of this, we investigated whether miR-155 played a role in SSc and if its expression was dependent on inflammasome activation...
June 17, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28621739/root-system-water-consumption-pattern-identification-on-time-series-data
#15
Manuel Figueroa, Christopher Pope
In agriculture, soil and meteorological sensors are used along low power networks to capture data, which allows for optimal resource usage and minimizing environmental impact. This study uses time series analysis methods for outliers' detection and pattern recognition on soil moisture sensor data to identify irrigation and consumption patterns and to improve a soil moisture prediction and irrigation system. This study compares three new algorithms with the current detection technique in the project; the results greatly decrease the number of false positives detected...
June 16, 2017: Sensors
https://www.readbyqxmd.com/read/28621173/evaluation-and-management-approaches-for-scleroderma-lung-disease
#16
Sara R Schoenfeld, Flavia V Castelino
Interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH) are leading causes of morbidity and mortality in systemic sclerosis (SSc). As symptoms are often under-reported in SSc, early screening of ILD and PAH is of paramount importance, and early treatment may be associated with better clinical outcomes. Serologies are particularly helpful in identifying patients at risk for pulmonary involvement. Pulmonary function testing, high-resolution computed tomography of the chest and echocardiography are important tools in the initial screening of these patients...
June 1, 2017: Therapeutic Advances in Respiratory Disease
https://www.readbyqxmd.com/read/28620623/resolution-of-diffuse-intrahepatic-biliary-strictures-after-chemotherapy-for-metastatic-ovarian-cancer
#17
Daniel Lew, Vinay Sundaram, Brad D Barrows, Simon K Lo, Srinivas Gaddam
Sclerosing cholangitis and cholestatic jaundice secondary to metastatic disease is a rare complication. We report a rare case of secondary sclerosing cholangitis (SSC) due to lymphatic spread from ovarian cancer with complete resolution after chemotherapy. The diagnosis of SSC from metastatic ovarian cancer was clinically challenging, as endoscopic retrograde cholangiopancreatography revealed irregular hepatic ducts consistent with sclerosing cholangitis, but it did not identify any malignant cells. The final diagnosis was made with liver biopsy revealing high-grade metastatic Mullerian carcinoma...
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28619664/nailfold-capillaroscopic-changes-in-patients-with-idiopathic-pulmonary-arterial-hypertension-and-systemic-sclerosis-related-pulmonary-arterial-hypertension
#18
A Corrado, M Correale, N Mansueto, I Monaco, A Carriero, A Mele, R Colia, M Di Biase, F P Cantatore
Pulmonary arterial hypertension (PAH) represents one of the main clinical expressions of the vascular changes in systemic sclerosis (SSc). Lung microvascular changes can play a role in the pathogenesis of idiopathic PAH (IPAH) also. The aim of this study is to investigate the presence of capillaroscopic abnormalities in patients with IPAH and to evaluate the differences in capillary nailfold changes between patients with IPAH and patients with SSc with and without PAH. METHODS: 39 SSc patients (19 with PAH - SSc-PAH and 20 without - SSc-noPAH), 21 subjects with IPAH and 20 healthy subjects were recruited...
June 12, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28617867/complete-chloroplast-genome-sequence-of-common-bermudagrass-cynodon-dactylon-l-pers-and-comparative-analysis-within-the-family-poaceae
#19
Ya-Yi Huang, Shu-Ting Cho, Mindia Haryono, Chih-Horng Kuo
Common bermudagrass (Cynodon dactylon (L.) Pers.) belongs to the subfamily Chloridoideae of the Poaceae family, one of the most important plant families ecologically and economically. This grass has a long connection with human culture but its systematics is relatively understudied. In this study, we sequenced and investigated the chloroplast genome of common bermudagrass, which is 134,297 bp in length with two single copy regions (LSC: 79,732 bp; SSC: 12,521 bp) and a pair of inverted repeat (IR) regions (21,022 bp)...
2017: PloS One
https://www.readbyqxmd.com/read/28612399/postharvest-gaseous-ozone-treatment-enhances-quality-parameters-and-delays-softening-in-cantaloupe-melon-during-storage-at-6%C3%A2-%C3%A2-c
#20
Mauro Toti, Cristian Carboni, Rinaldo Botondi
BACKGROUND: This trial shows postharvest gaseous ozone treatment to evaluate the quality parameters and cell wall enzymes during the Cantaloupe melon cv Caldeo storage at 6 °C for 13 days. RESULTS: The fruits were kept in cold storage and treated with 0.15 ppm gaseous ozone during the day and 0.3 ppm overnight; the control fruits (CK) are stored in normal atmosphere. The firmness was higher and ethylene concentration was significantly lower on treated fruits compared to CK (untreated)...
June 14, 2017: Journal of the Science of Food and Agriculture
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