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https://www.readbyqxmd.com/read/25432684/physical-rehabilitation-after-total-joint-arthroplasty-in-companion-animals
#1
REVIEW
Denis J Marcellin-Little, Nancy D Doyle, Joanna Freeman Pyke
Patients who have total joint arthroplasty have varying needs related to rehabilitation. In the short term, rehabilitation should be used in all dogs to identify high-risk patients and to minimize the likelihood of postoperative complications. Many patients undergoing total hip replacement recover uneventfully without needing long-term physiotherapy. All patients undergoing total knee replacement and total elbow replacement need rehabilitation to restore limb use and maximize their functional recovery. This article presents rehabilitation considerations for companion animals undergoing total hip replacement, total knee replacement, and total elbow replacement; postoperative complications and how to mitigate risks; and anticipated patient outcomes...
January 2015: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/24951454/intra-articular-enzyme-replacement-therapy-with-rhidua-is-safe-well-tolerated-and-reduces-articular-gag-storage-in-the-canine-model-of-mucopolysaccharidosis-type-i
#2
Raymond Y Wang, Afshin Aminian, Michael F McEntee, Shih-Hsin Kan, Calogera M Simonaro, William C Lamanna, Roger Lawrence, N Matthew Ellinwood, Catalina Guerra, Steven Q Le, Patricia I Dickson, Jeffrey D Esko
BACKGROUND: Treatment with intravenous enzyme replacement therapy and hematopoietic stem cell transplantation for mucopolysaccharidosis (MPS) type I does not address joint disease, resulting in persistent orthopedic complications and impaired quality of life. A proof-of-concept study was conducted to determine the safety, tolerability, and efficacy of intra-articular recombinant human iduronidase (IA-rhIDUA) enzyme replacement therapy in the canine MPS I model. METHODS: Four MPS I dogs underwent monthly rhIDUA injections (0...
August 2014: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/24529507/muscular-dystrophy-in-a-dog-resembling-human-becker-muscular-dystrophy
#3
A B Baroncelli, F Abellonio, T B Pagano, I Esposito, B Peirone, S Papparella, O Paciello
A 3-year-old, male Labrador retriever dog was presented with clinical signs of progressive exercise intolerance, bilateral elbow extension, rigidity of the forelimbs, hindlimb flexion and kyphosis. Microscopical examination of muscle tissue showed marked variability in myofibre size, replacement of muscle with mature adipose tissue and degeneration/regeneration of muscle fibres, consistent with muscular dystrophy. Immunohistochemical examination for dystrophin showed markedly reduced labelling with monoclonal antibodies specific for the rod domain and the carboxy-terminal of dystrophin, while expression of β-sarcoglycan, γ-sarcoglycan and β-dystroglycan was normal...
May 2014: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/24479943/theory-and-development-of-a-unicompartmental-resurfacing-system-for-treatment-of-medial-compartment-disease-of-the-canine-elbow
#4
Samuel P Franklin, Kurt S Schulz, Josh Karnes, James L Cook
Medial compartment disease (MCompD) of the canine elbow can be defined as clinical signs attributable to articular cartilage loss of the medial coronoid process (MCP) of the ulna and medial aspect of the humeral condyle without significant lateral compartment pathology. Whereas outcomes associated with treatment of defined cohorts of dogs with MCompD have not been published, the impressions of many surgeons are that non-surgical management or surgical treatment of the MCP alone does not result in long term highly functional outcomes...
October 2014: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/23560883/an-ex-vivo-investigation-of-the-effect-of-the-tate-canine-elbow-arthroplasty-system-on-kinematics-of-the-elbow
#5
N J Burton, J R Ellis, K J Burton, A M Wallace, A R Wallace, G R Colborne
OBJECTIVE: To devise a kinematic technique to objectively ascertain the location and orientation of the centre of rotation of the canine elbow and to compare this axis following arthroplasty with the first generation TATE™ prosthesis in an ex vivo model. METHODS: Five pairs of cadaveric forelimbs were obtained and proximal limb soft tissues removed. Pin-mounted reflective markers were applied to the humerus and ulna. Limbs were mounted on a frame and six trials of the elbow manually cycled through its sagittal range of motion captured using 4 Qualisys cameras at 120 Hz...
May 2013: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/23550778/resistance-to-lateral-luxation-of-two-canine-total-elbow-replacement-systems-under-variable-mechanical-loads
#6
Nathan D Rose, Andy Freeman, Michael G Conzemius
OBJECTIVE: To measure the loads required to induce lateral luxation of the Iowa State University (ISU) elbow implant, a modified elbow implant, and the normal canine elbow with the ligaments and joint capsule removed. STUDY DESIGN: Mechanical testing on cadaveric specimens SAMPLE POPULATION: Twelve thoracic limbs were harvested from adult, medium sized dogs that had been euthanatized for reasons unrelated to the study. METHODS: The torque needed for luxation was identified on potted cadaver elbows under variable axial load and compared to ISU implants and modified implants...
May 2013: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/22943214/advances-in-total-joint-replacement-in-small-animals
#7
REVIEW
M J Allen
Total joint replacement is now considered a routine surgical option for small animals with advanced joint disease. This review highlights the current state of the art in total hip, elbow and knee replacement in small animals, as well as the potential for application to other joints such as the intervertebral discs, hock and shoulder. Advances in cementless fixation, the use of less-invasive, bone-sparing procedures, and the development of custom implant options for revision surgery and oncologic reconstruction will be discussed...
September 2012: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/22215295/-anatomical-and-pathophysiological-features-and-treatment-of-elbow-luxation-in-rabbits
#8
J Ertelt, J Maierl, A Kaiser, U Matis
OBJECTIVE: Functional anatomical evaluation of elbow luxation in rabbits and the comparison of this lesion to cats and dogs. MATERIAL AND METHODS: The relative frequency of elbow luxation and the most common direction of antebrachial bone dislocation in rabbits were compared catamnestically with data in dogs and cats. Goniometric evaluation of the range of motion of the elbow was carried out in 14 rabbits. This was followed by visualisation of the anatomical structures of cadaver elbows and measurement of the subchondral bone density of the elbow using computed tomographic osteoabsorptiometry in seven rabbits and seven cats...
2010: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/21936851/production-of-canine-mesenchymal-stem-cells-from-adipose-tissue-and-their-application-in-dogs-with-chronic-osteoarthritis-of-the-humeroradial-joints
#9
Annalisa Guercio, Patrizia Di Marco, Stefania Casella, Vincenza Cannella, Laura Russotto, Giuseppa Purpari, Santina Di Bella, Giuseppe Piccione
Autologous AD-MSC [adipose-derived MSC (mesenchymal stem cell)] therapy involves harvesting fat from the patient by isolating the stem and regenerative cells and administering the cells back to the patient. This study evaluated the production of canine AD-MSCs and their possible application in cellular therapy for dogs. To assess whether cellular therapy can replace drug therapy, the clinical effect of a single intra-articular injection of AD-MSCs was evaluated on 4 dogs with lameness associated with OA (osteoarthritis) of the humeroradial joints...
February 2012: Cell Biology International
https://www.readbyqxmd.com/read/19236685/nonconstrained-elbow-replacement-in-dogs
#10
REVIEW
Mike Conzemius
OBJECTIVE: To review development of a nonconstrained total elbow replacement system for use in dogs and report the surgical technique used for implantation. STUDY DESIGN: Descriptive report. ANIMALS: Dogs with chronic elbow osteoarthritis (OA) unresponsive to medical management for at least 1 year. METHODS: A nonconstrained elbow replacement system (radioulnar and humeral components) was developed and used in dogs with medically nonresponsive elbow OA...
February 2009: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/17686128/in-vitro-validation-of-a-technique-for-assessment-of-canine-and-feline-elbow-joint-collateral-ligament-integrity-and-description-of-a-new-method-for-collateral-ligament-prosthetic-replacement
#11
Michael Farrell, Davinia Draffan, Toby Gemmill, Dominic Mellor, Stuart Carmichael
OBJECTIVE: To assess the ability of an operator to differentiate intact from transected canine and feline elbow joint collateral ligaments (CL) using a reported manipulative test (Campbell's test) and to determine the potential for elbow joint luxation in canine and feline elbows with intact, transected, and surgically stabilized CL. STUDY DESIGN: In vitro biomechanical study. SAMPLE POPULATION: Canine (n=6) and feline cadavers (n=3). METHODS: Thoracic limb specimens were mounted on a custom-built jig with the elbows and carpi fixed in 90 degrees of flexion...
August 2007: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/16129140/total-joint-replacement-in-the-dog
#12
Michael G Conzemius, Jennifer Vandervoort
Total joint replacement has evolved over the past 50 years from a concept that was first attempted in people suffering from osteoarthritis to a commonly applied practice in veterinary medicine. Although many questions have been answered, several controversies still exist, with many implant and technical options being explored. Currently, total hip and elbow replacement are commercially available options viable for use in dogs. These options are detailed in this article. Joint replacement for other canine joints (ie, knee, hock, shoulder) that develop osteoarthritis likely will be developed in the near future...
September 2005: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/14648533/short-term-outcome-after-total-elbow-arthroplasty-in-dogs-with-severe-naturally-occurring-osteoarthritis
#13
Michael G Conzemius, Rhonda L Aper, Lisa B Corti
OBJECTIVE: To evaluate limb function in client-owned dogs before and after total elbow arthroplasty (TEA) for severe, naturally occurring osteoarthritis (OA). STUDY DESIGN: Prospective clinical evaluation comparing limb function before and after surgery. ANIMALS: Twenty adult, large breed dogs with elbow OA. METHODS: Physical, radiographic, and force platform gait examinations were performed on all dogs before surgery...
November 2003: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/11172456/evaluation-of-a-canine-total-elbow-arthroplasty-system-a-preliminary-study-in-normal-dogs
#14
M G Conzemius, R L Aper, C M Hill
OBJECTIVE: Short-term, in vivo evaluation of a total-elbow arthroplasty (TEA) system in normal dogs. STUDY DESIGN: Prospective evaluation comparing pre- and postoperative findings. ANIMALS: Six normal, skeletally mature, large-breed dogs. METHODS: Physical, radiographic, and force-plate gait examinations were performed on all dogs before surgery. TEA was performed in the dogs using a canine TEA system. Examinations were repeated every 8 weeks for 24 weeks, with an additional examination at 52 weeks...
January 2001: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/9463864/diagnostic-and-surgical-arthroscopy-in-osteochondrosis-lesions
#15
REVIEW
H J van Bree, B Van Ryssen
In the dog, as in man and the horse, arthroscopy has an important role in treatment of joint disease. In the shoulder, elbow, and stifle joints, surgical arthroscopy can and should replace the classical surgical methods of treating osteochondrosis lesions. In elbow and tarsocrural joint disorders, the diagnostic potentials of arthroscopy are evident. With the established techniques, not only can the lesions be diagnosed with accuracy, but they can also be treated within the same procedure, making arthroscopy the treatment of choice to deal with osteochondrosis lesions...
January 1998: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/9243788/surgical-treatment-of-osteoarthritis
#16
REVIEW
J L Cook, J T Payne
Surgical treatment of OA is appropriate when conservative therapy fails or is inadequate. The veterinary orthopedist's goals in treatment should be to alleviate pain, maintain function, and prevent or remove the potential for further degeneration of the joint. Currently, in veterinary surgery, THR and femoral head and neck excision are the primary treatments for OA of the coxofemoral joint. Other joints are treated primarily by arthrodesis or excision arthroplasty. Arthroscopy is proving to be a valuable tool in the diagnosis and treatment of OA, and total stifle and elbow replacement and cartilage resurfacing through chondrocyte grafting are on the horizon as potential treatment options...
July 1997: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/9048542/refined-structure-of-an-intact-igg2a-monoclonal-antibody
#17
L J Harris, S B Larson, K W Hasel, A McPherson
The structure of an intact, anti-canine lymphoma monoclonal antibody (Mab231) was determined by molecular replacement and refined in a triclinic cell to an R-value of 20.9%, using synchrotron diffraction data from 2.8 to 20 A resolution. All segments of the antibody, including the hinge region and carbohydrate component, are visible in electron density maps. There is no overall symmetry to the antibody, as the Fc is disposed in an entirely oblique manner with respect to the Fabs. The CH2 and CH3 domains do, however, possess a nearly exact, local 2-fold relationship...
February 18, 1997: Biochemistry
https://www.readbyqxmd.com/read/5183210/replacement-of-chronic-luxation-of-the-canine-elbow
#18
R L Leighton
No abstract text is available yet for this article.
August 1967: Veterinary Medicine, Small Animal Clinician: VM, SAC
https://www.readbyqxmd.com/read/1448155/the-three-dimensional-structure-of-an-intact-monoclonal-antibody-for-canine-lymphoma
#19
L J Harris, S B Larson, K W Hasel, J Day, A Greenwood, A McPherson
Crystal structures of Fab antibody fragments determined by X-ray diffraction characteristically feature four-domain, beta-barrel arrangements. A human antibody Fc fragment has also been found to have four beta-barrel domains. The structures of a few intact antibodies have been solved: in two myeloma proteins, the flexible hinge regions that connect the Fc to the Fab segments were deleted so the molecules were non-functional, structurally restrained, T-shaped antibodies; a third antibody, Kol, had no hinge residues missing but the Fc region was sufficiently disordered that it was not possible to relate its disposition accurately with respect to the Fab components...
November 26, 1992: Nature
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