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https://www.readbyqxmd.com/read/29026639/optimising-the-acceptability-and-feasibility-of-novel-complex-interventions-an-iterative-person-based-approach-to-developing-the-uk-morita-therapy-outpatient-protocol
#1
Holly Victoria Rose Sugg, David A Richards, Julia Frost
BACKGROUND: The aim of this paper is to showcase best practice in intervention development by illustrating a systematic, iterative, person-based approach to optimising intervention acceptability and feasibility, as applied to the cross-cultural adaptation of Morita therapy for depression and anxiety. METHODS: We developed the UK Morita therapy outpatient protocol over four stages integrating literature synthesis and qualitative research. Firstly, we conducted in-depth interviews combining qualitative and cognitive interviewing techniques, utilising vignettes of Morita therapy being delivered and analysed using Framework analysis to investigate potential patients and therapists' perceptions of Morita therapy...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28992899/tailored-online-cognitive-behavioural-therapy-with-or-without-therapist-support-calls-to-target-psychological-distress-in-adults-receiving-haemodialysis-a-feasibility-randomised-controlled-trial
#2
Joanna L Hudson, Rona Moss-Morris, Sam Norton, Federica Picariello, David Game, Amy Carroll, Jonathan Spencer, Paul McCrone, Matthew Hotopf, Lucy Yardley, Joseph Chilcot
BACKGROUND: Psychological distress is prevalent in haemodialysis (HD) patients yet access to psychotherapy remains limited. This study assessed the feasibility and acceptability of online cognitive-behavioural therapy (CBT) tailored for HD patients, with or without therapist support, for managing psychological distress. METHODS: This feasibility randomised controlled trial recruited patients from a UK HD centre. Following psychological distress screens, patients with mild-moderate psychological distress (Patient Health Questionnaire PHQ-9; score: 5-19 and/or Generalised Anxiety Disorder; GAD-7 score: 5-14) who met remaining inclusion criteria were approached for consent...
November 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28985589/screening-for-psychological-distress-using-the-patient-health-questionnaire-anxiety-and-depression-scale-phq-ads-initial-validation-of-structural-validity-in-dialysis-patients
#3
Joseph Chilcot, Joanna L Hudson, Rona Moss-Morris, Amy Carroll, David Game, Anna Simpson, Matthew Hotopf
OBJECTIVE: To validate the factor structure of the Patient Health Questionnaire Anxiety and Depression Scale (PHQ-ADS)- which is a composite measure of depression and anxiety using the Patient Health Questionnaire-9 and Generalised Anxiety Disorder Scale (GAD-7), in a sample of haemodialysis patients. METHOD: Screening data (n=182) used to select entry into a feasibility study of an online cognitive-behavioural therapy intervention for distress in dialysis patients were analysed here...
September 28, 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28967365/hypermobility-the-ehlers-danlos-syndromes-and-chronic-pain
#4
REVIEW
Delfien Syx, Inge De Wandele, Lies Rombaut, Fransiska Malfait
Chronic widespread pain is a common complaint among individuals affected by generalised joint hypermobility. In the absence of other conditions that cause chronic pain, these individuals are usually diagnosed with joint hypermobility syndrome (JHS). JHS is a multifactorial trait with a strong genetic basis, but no specific genetic markers. Clinical overlap of JHS is seen with heritable connective tissue disorders, particularly with the Ehlers-Danlos syndrome, hypermobile type (hEDS). The Ehlers-Danlos syndromes (EDS) comprise a heterogeneous group of rare monogenic conditions that are characterised by joint hypermobility, skin and vascular fragility and generalised connective tissue friability, and are caused by genetic defects in an array of extracellular matrix genes...
September 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28944321/effect-of-evacuation-and-displacement-on-the-association-between-flooding-and-mental-health-outcomes-a-cross-sectional-analysis-of-uk-survey-data
#5
Alice Munro, R Sari Kovats, G James Rubin, Thomas David Waite, Angie Bone, Ben Armstrong
BACKGROUND: Extensive flooding occurred during the winter of 2013-14 in England. Previous studies have shown that flooding affects mental health. Using data from the 2013-14 Public Health England National Study of Flooding and Health, we compared the prevalence of symptoms of depression, anxiety, and post-traumatic stress disorder between participants displaced by flooding and those flooded, but not displaced, 1 year after flooding. METHODS: In this multivariable ordinal regression analysis, we collected data from a cross-sectional survey collected 1 year after the flooding event from flood-affected postcodes in five counties in England...
July 2017: The Lancet. Planetary health
https://www.readbyqxmd.com/read/28898708/cue-exposure-therapy-reduces-overeating-of-exposed-and-non-exposed-foods-in-obese-adolescents
#6
Ghislaine Schyns, Anne Roefs, Fren T Y Smulders, Anita Jansen
BACKGROUND AND OBJECTIVES: This study tested whether two sessions of food cue exposure therapy reduced eating in the absence of hunger (EAH), specified for exposed and non-exposed food, in overweight and obese adolescents, and whether habituation of food cue reactivity and reduced CS-US expectancies predicted a decrease in EAH. METHODS: 41 overweight adolescents (aged 12-18 years) were randomly assigned to a cue exposure intervention or a lifestyle intervention (control condition)...
September 5, 2017: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/28886500/peripheral-proinflammatory-cytokines-in-chinese-patients-with-generalised-anxiety-disorder
#7
Zhen Tang, Gang Ye, Xinyun Chen, Mingzhi Pan, Jialin Fu, Tian Fu, Qichun Liu, Zhenyong Gao, David S Baldwin, Ruihua Hou
BACKGROUND: Inflammatory responses and inflammatory cytokines have been implicated in the pathogenesis of affective disorders, particularly major depression. Given the limited evidence relating to the potential role of proinflammatory cytokines in generalised anxiety disorder (GAD), we aimed to examine peripheral proinflammatory cytokines in Chinese patients with GAD. METHODS: A case-controlled cross-sectional study design, with recruitment of 48 patients with first episode GAD and 48 matched healthy controls...
January 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28877841/cognitive-behaviour-therapy-for-health-anxiety-in-medical-patients-champ-a-randomised-controlled-trial-with-outcomes-to-5-years
#8
Peter Tyrer, Paul Salkovskis, Helen Tyrer, Duolao Wang, Michael J Crawford, Simon Dupont, Sylvia Cooper, John Green, David Murphy, Georgina Smith, Sharandeep Bhogal, Shaeda Nourmand, Valentina Lazarevic, Gemma Loebenberg, Rachel Evered, Stephanie Kings, Antoinette McNulty, Yvonne Lisseman-Stones, Sharon McAllister, Kofi Kramo, Jessica Nagar, Steven Reid, Rahil Sanatinia, Katherine Whittamore, Gemma Walker, Aaron Philip, Hilary Warwick, Sarah Byford, Barbara Barrett
BACKGROUND: Health anxiety is an under-recognised but frequent cause of distress that is potentially treatable, but there are few studies in secondary care. OBJECTIVE: To determine the clinical effectiveness and cost-effectiveness of a modified form of cognitive-behaviour therapy (CBT) for health anxiety (CBT-HA) compared with standard care in medical outpatients. DESIGN: Randomised controlled trial. SETTING: Five general hospitals in London, Middlesex and Nottinghamshire...
September 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28871029/protocol-for-a-qualitative-study-exploring-perspectives-on-the-international-classification-of-diseases-11th-revision-using-lived-experience-to-improve-mental-health-diagnosis-in-nhs-england-include-study
#9
Corinna Hackmann, Amanda Green, Caitlin Notley, Amorette Perkins, Geoffrey M Reed, Joseph Ridler, Jon Wilson, Tom Shakespeare
INTRODUCTION: Developed in dialogue with WHO, this research aims to incorporate lived experience and views in the refinement of the International Classification of Diseases Mental and Behavioural Disorders 11th Revision (ICD-11). The validity and clinical utility of psychiatric diagnostic systems has been questioned by both service users and clinicians, as not all aspects reflect their lived experience or are user friendly. This is critical as evidence suggests that diagnosis can impact service user experience, identity, service use and outcomes...
September 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/28857658/minocycline-as-an-adjunct-for-treatment-resistant-depressive-symptoms-a-pilot-randomised-placebo-controlled-trial
#10
Muhammad I Husain, Imran B Chaudhry, Nusrat Husain, Ameer B Khoso, Raza R Rahman, Munir M Hamirani, John Hodsoll, Inti Qurashi, John Fw Deakin, Allan H Young
BACKGROUND: Evidence suggests that anti-inflammatory medication may be effective in the treatment of depressive symptoms. In this study, we aimed to investigate whether minocycline added to treatment as usual (TAU) for 3 months in patients with treatment-resistant depression will lead to an improvement in depressive symptoms. METHODS: Multi-site, 12-week, double-blind, placebo-controlled, pilot trial of minocycline added to TAU for patients suffering from DSM-5 major depressive disorder, whose current episode has failed to respond to at least two antidepressants...
August 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28857042/cost-and-outcome-of-behavioural-activation-cobra-a-randomised-controlled-trial-of-behavioural-activation-versus-cognitive-behavioural-therapy-for-depression
#11
David A Richards, Shelley Rhodes, David Ekers, Dean McMillan, Rod S Taylor, Sarah Byford, Barbara Barrett, Katie Finning, Poushali Ganguli, Fiona Warren, Paul Farrand, Simon Gilbody, Willem Kuyken, Heather O'Mahen, Ed Watkins, Kim Wright, Nigel Reed, Emily Fletcher, Steven D Hollon, Lucy Moore, Amy Backhouse, Claire Farrow, Julie Garry, Deborah Kemp, Faye Plummer, Faith Warner, Rebecca Woodhouse
BACKGROUND: Depression is a common, debilitating and costly disorder. The best-evidenced psychological therapy - cognitive-behavioural therapy (CBT) - is complex and costly. A simpler therapy, behavioural activation (BA), may be an effective alternative. OBJECTIVES: To determine the clinical effectiveness and cost-effectiveness of BA compared with CBT for depressed adults at 12 and 18 months' follow-up, and to investigate the processes of treatments. DESIGN: Randomised controlled, non-inferiority trial stratified by depression severity, antidepressant use and recruitment site, with embedded process evaluation; and randomisation by remote computer-generated allocation...
August 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28856899/building-a-bridge-a-case-report-on-communicating-mental-health-diagnoses-to-patients-of-a-culturally-and-linguistically-diverse-background
#12
Rony Kayrouz, Christine Irene Senediak, Roy Laube
OBJECTIVE: This paper is based on a case report, describing a protocol to help practitioners communicate mental-health diagnosis to patients from culturally and linguistically diverse (CALD) backgrounds. The protocol was presented by integrating the DSM-5 Cultural Formulation Interview (CFI) and the SPIKES protocol for communicating the diagnosis of cancer, yielding a modified CFI-SPIKES protocol (i.e. S, Support; P, Perception using CFI; I, Invitation; K, Knowledge; E, Emotions). The protocol was demonstrated using a case report with a patient of a Middle-Eastern background experiencing generalised anxiety disorder...
August 1, 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/28853392/pilot-of-a-randomised-controlled-trial-of-the-selective-serotonin-reuptake-inhibitor-sertraline-versus-cognitive-behavioural-therapy-for-anxiety-symptoms-in-people-with-generalised-anxiety-disorder-who-have-failed-to-respond-to-low-intensity-psychological-treatments
#13
Marta Buszewicz, John Cape, Marc Serfaty, Roz Shafran, Thomas Kabir, Peter Tyrer, Caroline S Clarke, Irwin Nazareth
BACKGROUND: Generalised anxiety disorder (GAD) is common, causing unpleasant symptoms and impaired functioning. The National Institute for Health and Care Excellence (NICE) guidelines have established good evidence for low-intensity psychological interventions, but a significant number of patients will not respond and require more intensive step 3 interventions, recommended as either high-intensity cognitive behavioural therapy (CBT) or a pharmacological treatment such as sertraline. However, there are no head-to-head comparisons evaluating which is more clinically effective and cost-effective, and current guidelines suggest that treatment choice at step 3 is based mainly on patient preference...
August 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28814971/quality-of-life-in-anxious-adolescents
#14
Solfrid Raknes, Ståle Pallesen, Joseph A Himle, Jon Fauskanger Bjaastad, Gro Janne Wergeland, Asle Hoffart, Kari Dyregrov, Åshild Tellefsen Håland, Bente Storm Mowatt Haugland
PURPOSE: To examine associations between health-related quality of life (HRQoL) and anxiety symptoms across anxiety domains (obsessions/compulsions, social anxiety, panic disorder, agoraphobia, separation anxiety, physical injury fears, generalised anxiety, and posttraumatic stress) in a general adolescent population. Expanded knowledge about these associations can provide valuable information for improving interventions and prevention strategies for adolescent anxiety. METHODS: Cross-sectional data about anxiety were collected via a school survey from a community sample of Norwegian adolescents aged 12-17 (N = 1719)...
2017: Child and Adolescent Psychiatry and Mental Health
https://www.readbyqxmd.com/read/28814317/collaborative-care-for-panic-disorder-generalised-anxiety-disorder-and-social-phobia-in-general-practice-study-protocol-for-three-cluster-randomised-superiority-trials
#15
Nadja Kehler Curth, Ursula Ødum Brinck-Claussen, Annette Sofie Davidsen, Marianne Engelbrecht Lau, Merete Lundsteen, John Hagel Mikkelsen, Claudio Csillag, Carsten Hjorthøj, Merete Nordentoft, Lene Falgaard Eplov
BACKGROUND: People with anxiety disorders represent a significant part of a general practitioner's patient population. However, there are organisational obstacles for optimal treatment, such as a lack of coordination of illness management and limited access to evidence-based treatment such as cognitive behavioral therapy. A limited number of studies suggest that collaborative care has a positive effect on symptoms for people with anxiety disorders. However, most studies are carried out in the USA and none have reported results for social phobia or generalised anxiety disorder separately...
August 16, 2017: Trials
https://www.readbyqxmd.com/read/28795914/domestic-violence-and-mental-health-a-cross-sectional-survey-of-women-seeking-help-from-domestic-violence-support-services
#16
Giulia Ferrari, Roxane Agnew-Davies, Jayne Bailey, Louise Howard, Emma Howarth, Tim J Peters, Lynnmarie Sardinha, Gene Solomon Feder
Background Domestic violence and abuse (DVA) are associated with increased risk of mental illness, but we know little about the mental health of female DVA survivors seeking support from domestic violence services. Objective Our goal was to characterise the demography and mental health of women who access specialist DVA services in the United Kingdom and to investigate associations between severity of abuse and measures of mental health and health state utility, accounting for important confounders and moderators...
December 2016: Global Health Action
https://www.readbyqxmd.com/read/28789715/metabolic-alterations-in-generalised-anxiety-disorder-a-review-of-proton-magnetic-resonance-spectroscopic-studies
#17
G Delvecchio, J A Stanley, A C Altamura, P Brambilla
Generalised anxiety disorder (GAD) is a common psychiatric illness characterised by selective morpho-functional brain alterations. The breath of neuroimaging studies investigating the neural basis of GAD is extensive; however, its pathophysiology is still largely unknown. Specifically for proton Magnetic Resonance Spectroscopy (¹H MRS) investigations, which have the aim of identifying differences in metabolite levels between conditions in key brain areas, often showed contrasting results. Indeed, there are selected ¹H MRS studies reporting deficits of key metabolites in GAD patients; however, collectively the literature remains mixed with respect to consistency of major findings...
August 9, 2017: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/28782098/measuring-generalised-expectancies-for-negative-mood-regulation-in-china-the-chinese-language-negative-mood-regulation-scale
#18
Guofang Wang, Jack Mearns, Xiaohui Yang, Peng Han, Salvatore J Catanzaro
Negative mood regulation expectancies (NMRE) represent people's confidence that they can alleviate their negative affect or induce a positive emotional state through thought or action. NMRE predict coping behaviour and mood outcomes for individuals under stress. Since 1990, much research documents the reliability and validity of the English language Negative Mood Regulation (NMR) scale as a measure of NMRE. The current research reports two studies developing a Chinese language translation of the NMR (NMR-C) scale that goes beyond literal translation to be a culturally sensitive measure of NMRE in China...
August 6, 2017: International Journal of Psychology: Journal International de Psychologie
https://www.readbyqxmd.com/read/28764770/psychometric-properties-of-the-short-warwick-edinburgh-mental-well-being-scale-swemwbs-in-service-users-with-schizophrenia-depression-and-anxiety-spectrum-disorders
#19
Janhavi Ajit Vaingankar, Edimansyah Abdin, Siow Ann Chong, Rajeswari Sambasivam, Esmond Seow, Anitha Jeyagurunathan, Louisa Picco, Sarah Stewart-Brown, Mythily Subramaniam
BACKGROUND: To establish the validity and reliability of the Short Warwick Edinburgh Mental Well-being Scale (SWEMWBS) in service users with schizophrenia, depression and anxiety spectrum disorders in Singapore and estimate SWEMWBS scores across socio-demographic and the three psychiatric diagnostic groups in the sample. METHODS: This secondary analysis was conducted using data from a study among outpatients of a tertiary psychiatric hospital. In addition to the SWEMWBS, socio-demographic data and current psychiatric diagnosis were collected...
August 1, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28739577/common-pitfalls-and-mistakes-in-the-set-up-analysis-and-interpretation-of-results-in-network-meta-analysis-what-clinicians-should-look-for-in-a-published-article
#20
Anna Chaimani, Georgia Salanti, Stefan Leucht, John R Geddes, Andrea Cipriani
OBJECTIVE: Several tools have been developed to evaluate the extent to which the findings from a network meta-analysis would be valid; however, applying these tools is a time-consuming task and often requires specific expertise. Clinicians have little time for critical appraisal, and they need to understand the key elements that help them select network meta-analyses that deserve further attention, optimising time and resources. This paper is aimed at providing a practical framework to assess the methodological robustness and reliability of results from network meta-analysis...
July 24, 2017: Evidence-based Mental Health
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