keyword
https://read.qxmd.com/read/38492853/time-dependent-ultrastructural-changes-during-venous-thrombogenesis-and-thrombus-resolution
#21
JOURNAL ARTICLE
Irina N Chernysh, Subhradip Mukhopadhyay, Tierra A Johnson, Jacob A Brooks, Rajabrata Sarkar, John W Weisel, Toni M Antalis
BACKGROUND: Deep venous thrombosis (DVT) is a common vascular event that can result in debilitating morbidity and even death due to pulmonary embolism. Clinically, patients with faster resolution of a venous thrombus have improved prognosis, but the detailed structural information regarding changes that occur in a resolving thrombus over time is lacking. OBJECTIVE: To define the spatial-morphological characteristics of venous thrombus formation, propagation, and resolution at the submicron level over time...
March 14, 2024: Journal of Thrombosis and Haemostasis: JTH
https://read.qxmd.com/read/38490102/implantation-of-a-double-allogeneic-human-engineered-tissue-graft-on-damaged-heart-insights-from-the-periscope-phase-i-clinical-trial
#22
JOURNAL ARTICLE
Antoni Bayes-Genis, Paloma Gastelurrutia, Marta Monguió-Tortajada, Maria Luisa Cámara, Cristina Prat-Vidal, German Cediel, Luciano Rodríguez-Gómez, Albert Teis, Elena Revuelta-López, Gemma Ferrer-Curriu, Santiago Roura, Carolina Gálvez-Montón, Felipe Bisbal, Joaquim Vives, Anna Vilarrodona, Christian Muñoz-Guijosa, Sergi Querol
BACKGROUND: In preclinical studies, the use of double allogeneic grafts has shown promising results in promoting tissue revascularization, reducing infarct size, preventing adverse remodelling and fibrosis, and ultimately enhancing cardiac function. Building upon these findings, the safety of PeriCord, an engineered tissue graft consisting of a decellularised pericardial matrix and umbilical cord Wharton's jelly mesenchymal stromal cells, was evaluated in the PERISCOPE Phase I clinical trial (NCT03798353), marking its first application in human subjects...
March 14, 2024: EBioMedicine
https://read.qxmd.com/read/38489995/iron-homeostasis-in-older-adults-balancing-nutritional-requirements-and-health-risks
#23
REVIEW
Rola S Zeidan, Matthew Martenson, Javier A Tamargo, Christian McLaren, Armin Ezzati, Yi Lin, Jae Jeong Yang, Hyung-Suk Yoon, Taylor McElroy, James F Collins, Christiaan Leeuwenburgh, Robert T Mankowski, Stephen Anton
Iron plays a crucial role in many physiological processes, including oxygen transport, bioenergetics, and immune function. Iron is assimilated from food and also recycled from senescent red blood cells. Iron exists in two dietary forms: heme (animal based) and non-heme (mostly plant based). The body uses iron for metabolic purposes, and stores the excess mainly in splenic and hepatic macrophages. Physiologically, iron excretion in humans is inefficient and not highly regulated, so regulation of intestinal absorption maintains iron homeostasis...
March 14, 2024: Journal of Nutrition, Health & Aging
https://read.qxmd.com/read/38487913/-how-i-explore%C3%A2-anemia-in-children
#24
Élisa Hindryckx, Christophe Chantrain
Anemia is a common problem in pediatrics. The most frequent cause is iron deficiency, but it can also be associated to a constitutional or acquired pathology of the bone marrow or red blood cells. We describe a practical approach for rapidly guiding the diagnosis and management of anemia in children. It is based on the history and clinical examination, mean corpuscular volume, ferritinemia, reticulocytosis and hemolytic profile.
March 2024: Revue Médicale de Liège
https://read.qxmd.com/read/38486821/synergistic-effect-of-metformin-and-vitamin-d-3-on-osteogenic-differentiation-of-human-adipose-tissue-derived-mesenchymal-stem-cells-under-high-d-glucose-conditions
#25
JOURNAL ARTICLE
Nhi Nguyen-Yen Ha, Thi Kim Tan Huynh, Ngoc Uyen Phuong Phan, Thi-Hiep Nguyen, Long Binh Vong, Nhu-Thuy Trinh
INTRODUCTION: Vitamin D3 plays a vital role in bone health, with low levels of vitamin D3 being related to skeletal fragility, fractures, and metabolic disorders such as diabetes. Metformin is known as an antihyperglycemic agent for regulating blood sugar. A correlation between diabetes mellitus and osteoporosis is attracting considerable interest, and research to find the prevention and treatment is gradually being studied. In this study, we investigated the effect of metformin and vitamin D3 on osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells (AT-MSCs) under high d-glucose concentrations and optimized by combining vitamin D3 and metformin in the process...
March 2024: Regenerative Therapy
https://read.qxmd.com/read/38483756/ilk-inhibition-reduces-osteophyte-formation-through-suppression-of-osteogenesis-in-bmscs-via-akt-gsk-3%C3%AE-%C3%AE-catenin-pathway
#26
JOURNAL ARTICLE
Zhixiang Huang, Lixin Huang, Jiali Ding, Yukai Huang, Xuechan Huang, Tianwang Li
BACKGROUND: Osteophyte development is a common characteristic of inflammatory skeletal diseases. Elevated osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) participates in pathological osteogenesis. Integrin-linked kinase (ILK) positively regulates the osteoblastic differentiation of osteoprogenitors, but whether the ILK blockage prevents osteophytes and its potential mechanism is still unknown. Furthermore, the low-dose tumor necrosis factor-α (TNF-α) promotes osteogenic differentiation, but a lack of study reports on the relationship between this cytokine and ILK...
March 14, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38480050/clinical-profile-and-serological-correlation-with-haemolysis-in-dat-positive-autoimmune-haemolytic-anaemia-patients-in-bangladesh
#27
JOURNAL ARTICLE
Anika Mahmood, Ayesha Khatun, Mahamudul Hasan, Sonia Shormin Miah, Md Mazharul Hoque Tapan, Atiar Rahman
Discerning the type of autoimmune haemolytic anaemia (AIHA) is crucial for transfusion support and initiation of treatment. This study aimed to establish the clinical profile and serological character of red cell autoantibodies and to investigate the relationship with haemolysis in AIHA patients who were direct antiglobulin test (DAT)-positive. A total of 59 DAT-positive AIHA patients were included in this study. Clinical, laboratory and serological findings were evaluated to find the gradation of haemolysis and to investigate its correlation with age, sex, type of autoantibody and level of autoantibody...
February 24, 2024: Pathology
https://read.qxmd.com/read/38479555/comp-promotes-pancreatic-fibrosis-by-activating-pancreatic-stellate-cells-through-cd36-erk-akt-signaling-pathways
#28
JOURNAL ARTICLE
Yi Wang, Hai-Tao Li, Gang Liu, Chuan-Shen Jiang, Yan-Hong Ni, Jing-Hui Zeng, Xia Lin, Qing-Yun Wang, Da-Zhou Li, Wen Wang, Xiang-Peng Zeng
BACKGROUND: Pancreatic fibrosis is one of the most important pathological features of chronic pancreatitis (CP) and pancreatic stellate cells (PSCs) are the key cells of fibrosis. As an extracellular matrix (ECM) glycoprotein, cartilage oligomeric matrix protein (COMP) is critical for collagen assembly and ECM stability and recent studies showed that COMP exert promoting fibrosis effect in the skin, lungs and liver. However, the role of COMP in activation of PSCs and pancreatic fibrosis remain unclear...
March 11, 2024: Cellular Signalling
https://read.qxmd.com/read/38478142/bmsc-derived-exosomes-carrying-mir-26a-5p-ameliorate-spinal-cord-injury-via-negatively-regulating-ezh2-and-activating-the-bdnf-trkb-creb-signaling
#29
JOURNAL ARTICLE
Min Chen, Yu Lin, Wenbin Guo, Lihui Chen
BACKGROUND: Spinal cord injury (SCI) is a destructive neurological and pathological state that causes major motor, sensory and autonomic dysfunctions. Bone marrow mesenchymal stem cells (BMSCs)-derived exosomes show great therapeutic potential for SCI. Exosomes derived from miR-26a-modified MSCs promote axonal regeneration following SCI. Our study aims to uncover the mechanisms by which BMSC-derived exosomes carrying miR-26a-5p regulate SCI. METHODS: BMSCs and BMSC-derived exosomes were isolated and characterized by Oil Red O and alizarin red staining, transmission electron microscopy, flow cytometry, nanoparticle tracking analysis and Western blotting...
March 13, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38477421/in-depth-investigation-of-fam20a-insufficiency-effects-on-deciduous-dental-pulp-cells-altered-behaviours-osteogenic-differentiation-and-inflammatory-gene-expression
#30
JOURNAL ARTICLE
Kanokwan Sriwattanapong, Thanakorn Theerapanon, Chompak Khamwachirapitak, Pannagorn Sae-Ear, Noppadol Sa-Ard-Iam, Vorasuk Shotelersuk, Thantrira Porntaveetus
AIM: Loss-of-function mutations in FAM20A result in amelogenesis imperfecta IG (AI1G) or enamel-renal syndrome, characterized by hypoplastic enamel, ectopic calcification, and gingival hyperplasia, with some cases reporting spontaneous tooth infection. Despite previous reports on the consequence of FAM20A reduction in gingival fibroblasts and transcriptome analyses of AI1G pulp tissues, suggesting its involvement in mineralization and infection, its role in deciduous dental pulp cells (DDP) remains unreported...
March 13, 2024: International Endodontic Journal
https://read.qxmd.com/read/38473116/ectopic-pregnancy-and-t-cell-lymphoma-in-a-eurasian-red-squirrel-sciurus-vulgaris-possible-comorbidity-and-a-comparative-pathology-perspective
#31
Caterina Raso, Valentina Galietta, Claudia Eleni, Marco Innocenti, Niccolò Fonti, Tiziana Palmerini, Mauro Grillo, Pietro Calderini, Elena Borgogni
Ectopic pregnancy (EP) is a life-threatening disease that affects humans and other mammals. Tumors causing ruptures of the reproductive tract have been identified as possible predisposing factors in human and veterinary medicine. We here describe a case of concomitant ectopic pregnancy and lymphoma in a Eurasian red squirrel found deceased in Italy and submitted to the public health laboratory Istituto Zooprofilattico Sperimentale del Lazio e della Toscana (IZSLT) for post-mortem examination. A full-term partially mummified ectopic fetus in the abdomen and a large fibrinonecrotic tubal scar adjacent to the right ovary were observed at necropsy...
February 27, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38469636/association-between-the-red-blood-cell-distribution-width-and-30-day-mortality-in-intensive-care-patients-undergoing-cardiac-surgery-a-retrospective-observational-study-based-on-the-medical-information-mart-for-intensive-care-iv-database
#32
JOURNAL ARTICLE
Weiqiang Chen, Peiling Yu, Chao Chen, Shaoyan Cai, Junheng Chen, Chunqin Zheng, Chaojin Chen, Liangjie Zheng, Chunming Guo
BACKGROUND: Millions of patients undergo cardiac surgery each year. The red blood cell distribution width (RDW) could help predict the prognosis of patients who undergo percutaneous coronary intervention or coronary artery bypass surgery. We investigated whether the RDW has robust predictive value for the 30-day mortality among patients in an intensive care unit (ICU) after undergoing cardiac surgery. METHODS: Using the Medical Information Mart for Intensive Care-IV Database, we retrieved data for 11,634 patients who underwent cardiac surgery in an ICU...
March 12, 2024: Annals of Laboratory Medicine
https://read.qxmd.com/read/38466071/mechanistic-study-of-glycyrrhizic-acid-improving-alcoholic-fatty-liver-disease-by-modulating-the-shp1-syk-signaling-pathway-in-macrophages
#33
JOURNAL ARTICLE
Qian Liu, Yuanyuan Li, Junqing Li, Junying Zhou
OBJECTIVE: To investigate glycyrrhizin's effects and molecular mechanisms on the progression of alcoholic fatty liver. METHODS: An alcoholic fatty liver model was established, followed by the administration of glycyrrhizin ammonium (20 mg/kg). Liver tissue pathological changes were observed using oil red O staining, and pyroptotic bodies were observed using transmission electron microscopy. Western blot was used to detect the expression of related proteins. To establish a model of alcoholic fatty liver cells to explore the molecular mechanism of glycolic acid in this disease...
March 8, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38459540/characterization-of-preclinical-alzheimer-s-disease-model-spontaneous-type-2-diabetic-cynomolgus-monkeys-with-systemic-pro-inflammation-positive-biomarkers-and-developing-ad-like-pathology
#34
JOURNAL ARTICLE
Xinxin Huang, Shanshan Huang, Fangyan Fu, Junzhen Song, Yuling Zhang, Feng Yue
BACKGROUND: The key to the prevention and treatment of Alzheimer's disease (AD) is to be able to predict and diagnose AD at the preclinical or early stage, but the lack of a preclinical model of AD is the critical factor that causes this problem to remain unresolved. METHODS: We assessed 18 monkeys in vivo evaluation of pro-inflammatory cytokines and AD pathological biomarkers (n = 9 / type 2 diabetic mellitus (T2DM) group, age 20, fasting plasma glucose (FPG) ≥ 100 mg/dL, and n = 9 / negative control (NC) group, age 17, FPG < 100 mg/dL)...
March 8, 2024: Alzheimer's Research & Therapy
https://read.qxmd.com/read/38456066/inflammation-as-a-cause-of-acute-myocardial-infarction-in-patients-with-myeloproliferative-neoplasm
#35
EDITORIAL
Amedeo Tirandi, Elisa Schiavetta, Elia Maioli, Fabrizio Montecucco, Luca Liberale
Myeloproliferative neoplasms (MPN) are a group of diseases characterized by the clonal proliferation of hematopoietic progenitor or stem cells. They are clinically classifiable into four main diseases: chronic myeloid leukemia, essential thrombocythemia, polycythemia vera, and primary myelofibrosis. These pathologies are closely related to cardio- and cerebrovascular diseases due to the increased risk of arterial thrombosis, the most common underlying cause of acute myocardial infarction. Recent evidence shows that the classical Virchow triad (hypercoagulability, blood stasis, endothelial injury) might offer an explanation for such association...
February 26, 2024: World Journal of Cardiology
https://read.qxmd.com/read/38447400/erythrocyte-membrane-coated-with-nitrogen-doped-quantum-dots-and-polydopamine-composite-nano-system-combined-with-photothermal-treatment-of-alzheimer-s-disease
#36
JOURNAL ARTICLE
Jichun Liu, Mingyuan Chi, Lianxin Li, Yuewen Zhang, Meng Xie
Mitochondrial dysfunction and metal ion imbalance are recognized as pathological hallmarks of Alzheimer's Disease (AD), leading to deposition of β-amyloid (Aβ) thereby and inducing neurotoxicity, activating apoptosis, eliciting oxidative stress, and ultimately leading to cognitive impairment. In this study, the red blood cell membrane (RBC) was used as a vehicle for encapsulating carbon quantum dots (CQD) and polydopamine (PDA), creating a nanocomposite (PDA-CQD/RBC). This nanocomposite was combined with near-infrared light (NIR) for AD treatment...
March 2, 2024: Journal of Colloid and Interface Science
https://read.qxmd.com/read/38443508/improved-green-and-red-grab-sensors-for-monitoring-spatiotemporal-serotonin-release-in-vivo
#37
JOURNAL ARTICLE
Fei Deng, Jinxia Wan, Guochuan Li, Hui Dong, Xiju Xia, Yipan Wang, Xuelin Li, Chaowei Zhuang, Yu Zheng, Laixin Liu, Yuqi Yan, Jiesi Feng, Yulin Zhao, Hao Xie, Yulong Li
The serotonergic system plays important roles in both physiological and pathological processes, and is a therapeutic target for many psychiatric disorders. Although several genetically encoded GFP-based serotonin (5-HT) sensors were recently developed, their sensitivities and spectral profiles are relatively limited. To overcome these limitations, we optimized green fluorescent G-protein-coupled receptor (GPCR)-activation-based 5-HT (GRAB5-HT ) sensors and developed a red fluorescent GRAB5-HT sensor. These sensors exhibit excellent cell surface trafficking and high specificity, sensitivity and spatiotemporal resolution, making them suitable for monitoring 5-HT dynamics in vivo...
March 5, 2024: Nature Methods
https://read.qxmd.com/read/38442806/hawthorn-leaf-flavonoids-alleviate-the-deterioration-of-atherosclerosis-by-inhibiting-scap-srebp2-ldlr-pathway-through-spla2-%C3%A2-a-signaling-in-macrophages-in-mice
#38
JOURNAL ARTICLE
Xufeng Bai, Shuwen Wang, Limei Shu, Qingyu Cao, Huiming Hu, Yanchen Zhu, Chen Chen
ETHNOPHARMACOLOGICAL RELEVANCE: Hawthorn leaves are a combination of the dried leaves of the Rosaceae plants, i.e., Crataegus pinnatifida Bge. or Crataegus pinnatifida Bge. var. major N. E. Br., is primarily cultivated in East Asia, North America, and Europe. hawthorn leaf flavonoids (HLF) are the main part of extraction. The HLF have demonstrated potential in preventing hypertension, inflammation, hyperlipidemia, and atherosclerosis. However, the potential pharmacological mechanism behind its anti-atherosclerotic effect has yet to be explored...
March 3, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38441397/role-of-mesenchymal-stem-cells-derived-exosomes-on-inflammation-apoptosis-fibrosis-and-telocyte-modulation-in-doxorubicin-induced-cardiotoxicity-a-closer-look-at-the-structural-level
#39
JOURNAL ARTICLE
Reda A El Nasser Imam, Basma Emad Aboulhoda, Maha M Amer, Fatma E Hassan, Mansour A Alghamdi, Mohamed R Abdel-Hamed
Cardiotoxicity induced by doxorubicin (Dox) is a major complication in cancer patients. Exosomes (Ex) derived from mesenchymal cells could be a promising therapeutic for various heart diseases. This study investigated the role of Ex in Dox-induced cardiotoxicity and its mechanistic insights, using Sacubitril/valsartan (S/V) as a reference drug widely recommended in heart failure management. The study involved 24 Wistar rats, divided into a control, Dox, Dox + S/V, and Dox + Ex groups...
March 5, 2024: Microscopy Research and Technique
https://read.qxmd.com/read/38433116/immune-mediated-hemolytic-anemia-and-pure-red-cell-aplasia-in-a-jack-russell-terrier-during-treatment-for-hypoadrenocorticism
#40
Shunya Yokota, Masashi Yuki
An 11-year-old neutered male Jack Russell Terrier was presented to Yuki Animal Hospital for regenerative anemia during the treatment of hypoadrenocorticism. A blood smear examination showed spherocytes, polychromatic erythrocytes, and erythrocyte ghosts. The direct agglutination test was positive at 37°C. The dog was then diagnosed with immune-mediated hemolytic anemia (IMHA). Although prednisolone and mycophenolate mofetil were administered, the hematocrit and reticulocyte count decreased, and nonregenerative anemia developed...
March 3, 2024: Veterinary Clinical Pathology
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