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Red cell pathology

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https://www.readbyqxmd.com/read/29241917/pueraria-mirifica-inhibits-17%C3%AE-estradiol-induced-cell-proliferation-of%C3%A2-human-endometrial-mesenchymal-stem-cells
#1
Ta-Chin Lin, Kai-Hung Wang, An-Pei Kao, Kuo-Hsiang Chuang, Tsung-Cheng Kuo
OBJECTIVE: The notion that the human endometrium may contain a population of stem cells has recently been proposed. The mesenchymal stem cells (MSCs) in the endometrium are believed to be responsible for the remarkable regenerative ability of endometrial cells. Estrogens influence the physiological and pathological processes of several hormone-dependent tissues, such as the endometrium. Pueraria mirifica (PM) is a herbal plant that contains several phytoestrogens, including isoflavones, lignans, and coumestans, and is known to exert an estrogenic effect on animal models...
December 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29227278/an-automated-method-for-dynamic-red-blood-cell-aggregate-detection-in-microfluidic-flow
#2
Rym Mehri, Erfan Niazi, Catherine Mavriplis, Marianne Fenech
Red blood cell (RBC) aggregation is a unique phenomenon that occurs when red blood cells are subjected to low shear rates. Little is known about the sizes, shapes and behaviour of aggregates flowing in healthy humans. However, excessive aggregation has been shown to be an indication of pathological conditions. Therefore, characterizing RBC aggregates is important to medical research. The objective of this study was to develop a reliable technique based on image processing to assess and characterize human RBC aggregation subjected to controlled and measurable shear rates in a two-fluid flow microfluidic shearing system...
December 11, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/29217782/rational-management-approach-to-pure-red-cell-aplasia
#3
Suresh Kumar Balasubramanian, Meena Sadaps, Swapna Thota, Mai Aly, Bartlomiej P Przychodzen, Cassandra M Hirsch, Valeria Visconte, Tomas Radivoyevitch, Jaroslaw P Maciejewski
Pure red cell aplasia is an orphan disease without rationally established standard therapies. Most cases are idiopathic; a subset is antibody-mediated. There is overlap between idiopathic cases and those with T-large granular lymphocytic leukemia, hypogammaglobulinemia, and low-grade lymphomas. In all these, the pathogenetic mechanisms may involve autoreactive cytotoxic responses. We selected 62 uniformly diagnosed pure red cell aplasia patients and analyzed their pathophysiologic features and responsiveness to rationally applied first-line and salvage therapies to propose diagnostic and therapeutic algorithms that may help guide management of prospective patients...
December 7, 2017: Haematologica
https://www.readbyqxmd.com/read/29205375/comparison-of-direct-in-house-cerebrospinal-fluid-cytology-with-commercial-pathology-results-in-dogs
#4
P L Newton, D R Fry, M P Best
OBJECTIVES: To investigate the correspondence between in-house direct cytological assessment of cerebrospinal fluid and results from a commercial veterinary pathology laboratory. METHODS: Prospective inclusion of samples from dogs that were presented for investigation of suspected neurological disease and had cerebrospinal fluid samples submitted to a commercial pathology laboratory for analysis. A board-certified veterinary pathologist assessed all cerebrospinal fluid samples, and a line smear was assessed in-house by two observers...
December 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29191734/splenomegaly-pathophysiological-bases-and-therapeutic-options
#5
Campbell V McKenzie, Chanukya K Colonne, Jia Hao Yeo, Stuart T Fraser
The spleen is the largest immune organ in the human body and is also essential for red blood cell homeostasis and iron recycling. An average human spleen is approximately 10 centimetres in length and weighs 150g. Pathological conditions can result in the spleen weighing in excess of 2000g and extending over 30 centrimetres in length. This remarkable property of the spleen to expand is termed splenomegaly. Splenomegaly can occur as a physiological response to stress or as a chronic process that is often detrimental to the wellbeing of the individual...
December 2, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29187904/multimodality-imaging-of-angiogenesis-in-a-rabbit-atherosclerotic-model-by-gebp11-peptide-targeted-nanoparticles
#6
Tao Su, Ya-Bin Wang, Dong Han, Jing Wang, Shun Qi, Lei Gao, Ya-Hui Shao, Hong-Yu Qiao, Jiang-Wei Chen, Shu-Hui Liang, Yong-Zhan Nie, Jia-Yi Li, Feng Cao
Background and Aims: Angiogenesis is an important pathological process during progression of plaque formation, which can result in plaque hemorrhage and vulnerability. This study aims to explore non-invasive imaging of angiogenesis in atherosclerotic plaque through magnetic resonance imaging (MRI) and positron emission tomography (PET) by using GEBP11 peptide targeted magnetic iron oxide nanoparticles in a rabbit model of atherosclerosis. Methods: The dual-modality imaging probe was constructed by coupling 2, 3-dimercaptosuccinnic acid-coated paramagnetic nanoparticles (DMSA-MNPs) and the PET 68Ga chelator 1,4,7-triazacyclononane-N, N', N''-triacetic acid (NOTA) to GEBP11 peptide...
2017: Theranostics
https://www.readbyqxmd.com/read/29180398/inhibition-of-heme-oxygenase-ameliorates-anemia-and-reduces-iron-overload-in-%C3%AE-thalassemia-mouse-model
#7
Daniel Garcia-Santos, Amel Hamdi, Zuzana Saxova, Carine Fillebeen, Kostas Pantopoulos, Monika Horvathova, Prem Ponka
Thalassemias are a heterogeneous group of red blood cell disorders, considered as major cause of morbidity and mortality among genetic diseases. However, there is still no universally available cure for thalassemias. The underlying basis of thalassemia pathology is the premature apoptotic destruction of erythroblasts causing ineffective erythropoiesis. In β-thalassemia, β-globin synthesis is reduced causing α-globin accumulation. Unpaired globin chains, with heme attached to them, accumulate in thalassemic erythroblasts causing oxidative stress and the premature cell death...
November 27, 2017: Blood
https://www.readbyqxmd.com/read/29180269/dysregulation-of-antioxidant-responses-in-patients-diagnosed-with-concomitant-primary-sclerosing-cholangitis-inflammatory-bowel-disease
#8
Colin T Shearn, David J Orlicky, Dennis R Petersen
OBJECTIVE: Primary Sclerosing Cholangitis (PSC) is a chronic cholestatic liver disease that is characterized by severe peri-biliary tract inflammation and fibrosis, elevated oxidative stress and hepatocellular injury. A hallmark of PSC patients is the concurrent diagnosis of Inflammatory Bowel Disease occurring in approximately 70%-80% of PSC patients (PSC/IBD). The objective of this study was to determine the impact of end stage PSC/IBD on cellular antioxidant responses and the formation of protein carbonylation...
November 24, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29178185/case-series-of-outcomes-of-a-standardized-surgical-approach-for-placenta-percreta-for-prevention-of-ureteral-lesions
#9
David Atallah, Malak Moubarak, Malek Nassar, Bernard Kassab, Michel Ghossain, Nadine El Kassis
OBJECTIVE: To report the outcomes of women with placenta percreta who were surgically treated by a specialized technique based on gynecologic oncology experience, and to demonstrate its safety in preventing ureteral lesions and reducing blood loss. METHODS: In the present retrospective study, data from patients with placenta percreta radically treated at Hôtel-Dieu de France, Beirut, Lebanon, between December 2012 and January 2017 were reviewed. Demographic, pathology, and delivery data, medical history, per-operative and postoperative information, and neonatal data were assessed...
November 27, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29171106/autophagy-regulates-cisplatin-induced-stemness-and-chemoresistance-via-the-upregulation-of-cd44-abcb1-and-adam17-in-oral-squamous-cell-carcinoma
#10
Prajna Paramita Naik, Subhadip Mukhopadhyay, Prashanta Kumar Panda, Niharika Sinha, Chandan Kanta Das, Rajakishore Mishra, Shankargouda Patil, Sujit Kumar Bhutia
OBJECTIVE: We inspected the relevance of CD44, ABCB1 and ADAM17 in OSCC stemness and deciphered the role of autophagy/mitophagy in regulating stemness and chemoresistance. MATERIAL AND METHODS: A retrospective analysis of CD44, ABCB1 and ADAM17 with respect to the various clinico-pathological factors and their correlation was analysed in sixty OSCC samples. Furthermore, the stemness and chemoresistance were studied in resistant oral cancer cells using sphere formation assay, flow cytometry and florescence microscopy...
November 23, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/29169901/-transfusion-practices-in-elderly-patients-a-descriptive-study-about-241%C3%A2-patients-at-the-university-hospital-of-brest
#11
C Le Niger, N Magne Tagne, A Gentric
Red blood cell transfusion is commonly required for elderly patients with little specific guidelines for this population. We wished to study the transfusion practices for patients aged≥75 years transfused with red blood cells in all units of our institution. The aim of this work is to describe this population of patients and to compare the transfusion practices to the HAS and ANSM guidelines published in 2014. METHODS: An observational study was performed including patients≥75 years, transfused with red blood cells between 27th January to 27th March 2014...
November 20, 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/29168661/spatio-temporal-dynamics-of-cerebral-capillary-segments-with-stalling-red-blood-cells
#12
Şefik Evren Erdener, Jianbo Tang, Amir Sajjadi, Kıvılcım Kılıç, Sreekanth Kura, Chris B Schaffer, David A Boas
Optical coherence tomography (OCT) allows label-free imaging of red blood cell (RBC) flux within capillaries with high spatio-temporal resolution. In this study, we utilized time-series OCT-angiography to demonstrate interruptions in capillary RBC flux in mouse brain in vivo. We noticed ∼7.5% of ∼200 capillaries had at least one stall in awake mice with chronic windows during a 9-min recording. At any instant, ∼0.45% of capillaries were stalled. Average stall duration was ∼15 s but could last over 1 min...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29163922/bright-and-sensitive-ratiometric-fluorescent-probe-enabling-endogenous-fa-imaging-and-mechanistic-exploration-of-indirect-oxidative-damage-due-to-fa-in-various-living-systems
#13
Kun Dou, Guang Chen, Fabiao Yu, Yuxia Liu, Lingxin Chen, Ziping Cao, Tao Chen, Yulin Li, Jinmao You
As a notorious toxin, formaldehyde (FA) poses an immense threat to human health. Aberrantly elevated FA levels lead to serious pathologies, including organ damage, neurodegeneration, and cancer. Unfortunately, current techniques limit FA imaging to general comparative studies, instead of a mechanistic exploration of its biological role, and this is presumably due to the lack of robust molecular tools for reporting FA in living systems. More importantly, despite being reductive, FA, however, can induce oxidative damage to organisms, thus providing a challenge to the mechanistic study of FA using fluorescence imaging...
November 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29162636/quantitative-proteomic-profiling-reveals-novel-plasmodium-falciparum-surface-antigens-and-possible-vaccine-candidates
#14
Sandra K Nilsson Bark, Rushdy Ahmad, Kathleen Dantzler, Amanda K Lukens, Mariana De Niz, Matthew J Szucs, Xiaojing Jin, Joanne Cotton, Dietmar Hoffmann, Eva Bric-Furlong, Ray Oomen, Mark Parrington, Dan Milner, Daniel E Neafsey, Steven A Carr, Dyann F Wirth, Matthias Marti
Despite recent efforts towards control and elimination, malaria remains a major public health problem worldwide. Plasmodium falciparum resistance against artemisinin, used in front line combination drugs, is on the rise, and the only approved vaccine shows limited efficacy. Combinations of novel and tailored drug and vaccine interventions are required to maintain the momentum of the current malaria elimination program. Current evidence suggests that strain-transcendent protection against malaria infection can be achieved using whole organism vaccination or with a polyvalent vaccine covering multiple antigens or epitopes...
November 21, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29162392/hematological-phenotypes-in-children-according-to-the-%C3%AE-globin-genotypes
#15
Raffaella Origa, Susanna Barella, Maria Elisabetta Paglietti, Franco Anni, Fabrice Danjou, Anna Rita Denotti, Maria Franca Desogus, Daniela Loi, Valeria Orecchia, Maria Carla Sollaino, Paolo Moi
Limited information is available on the hematological characterization of the α-thalassemia carrier in pediatric age. The objective of this report was to evaluate the red cell indices according to the α-globin genotype in a cohort of children evaluated in Sardinia. Moreover, we verified the frequency of different α-globin genotypes in this cohort. A total of 453 subjects were investigated for hematological indices and for the most common α-globin defects present in Sardinia. Of them, 352 with HbA2≤3.2%, and no iron deficiency anemia were taken into consideration to evaluate the red cell indices according to the α-globin genotype in pediatric age...
November 3, 2017: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/29156008/urinalysis-for-the-diagnosis-of-glomerulonephritis-role-of-dysmorphic-red-blood-cells
#16
Abdurrahman M Hamadah, Kamel Gharaibeh, Kristin C Mara, Katherine A Thompson, John C Lieske, Samar Said, Samih H Nasr, Nelson Leung
Background: Dysmorphic red blood cells (dRBCs) on urine microscopy have been associated with glomerulonephritis (GN). We assessed the prevalence and ability of dRBCs to differentiate GN from other kidney diseases. Methods: Adult patients with kidney biopsy performed between 2012 and 2015 at a single center who had a concurrent urinalysis were retrospectively studied. The association of ≥25% dRBCs with the presence of glomerular pathology was assessed. Univariate and multivariate logistic regression were performed on significantly associated variables...
October 6, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29155345/the-relationship-between-hematoma-and-pachymeninges-in-an-interdural-hematoma-diagnosis-and-surgical-strategy
#17
Ko-Ting Chen, Hsu-Chen Huang, Ya-Jui Lin, Ming-Houng Chen, Tsung-Che Hsieh
BACKGROUND: The exact location of a hematoma in relation to the pachymeninges contributes to typical radiographic presentations. However, because of the complexity of hematoma evolution and neomembrane formation, an unexpected intraoperative finding may lead to a change of surgical strategy. Besides, the concentration of hemoglobin and its degradation products, the integrity of red blood cells (RBCs), and the infiltration of fibroblasts, polymorphonuclear neutrophils, and macrophages are factors that affect the imaging characteristics on computed tomography (CT) and magnetic resonance imaging (MRI) as the hematoma ages...
November 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29149721/biological-safety-and-tissue-distribution-of-16-mercaptohexadecyl-trimethylammonium-bromide-modified-cationic-gold-nanorods
#18
Monika Zarska, Michal Sramek, Filip Novotny, Filip Havel, Andrea Babelova, Blanka Mrazkova, Oldrich Benada, Milan Reinis, Ivan Stepanek, Kamil Musilek, Jiri Bartek, Monika Ursinyova, Ondrej Novak, Rastislav Dzijak, Kamil Kuca, Jan Proska, Zdenek Hodny
The exceptionally high cellular uptake of gold nanorods (GNRs) bearing cationic surfactants makes them a promising tool for biomedical applications. Given the known specific toxic and stress effects of some preparations of cationic nanoparticles, the purpose of this study was to evaluate, in an in vitro and in vivo in mouse, the potential harmful effects of GNRs coated with (16-mercaptohexadecyl)trimethylammonium bromide ((MTAB)GNRs). Interestingly, even after cellular accumulation of high amounts of (MTAB)GNRs sufficient for induction of photothermal effect, no genotoxicity (even after longer-term accumulation), induction of autophagy, destabilization of lysosomes (dominant organelles of their cellular destination), alterations of actin cytoskeleton, or in cell migration could be detected in vitro...
November 1, 2017: Biomaterials
https://www.readbyqxmd.com/read/29145790/innate-immunity-in-cardiac-myxomas-and-its-pathological-and-clinical-correlations
#19
Anna Di Vito, Gianluca Santise, Chiara Mignogna, Eusebio Chiefari, Gabriella Cardillo, Ivan Presta, Franco Arturi, Natalia Malara, Francesco Brunetti, Annalidia Donato, Domenico Maisano, Stefania Leonetti, Daniele Maselli, Tullio Barni, Giuseppe Donato
Cardiac myxomas are the most common benign cardiac tumor. We investigated the immunohistochemical properties of 11 surgically excised cardiac myxomas, in order to analyze the correlation between macrophages and mast cell populations and clinical parameters. CD68(+)/CD163(-)/iNOS(-) (M0) cells represent the most abundant macrophage phenotype; however, CD68(+)/CD163(+) cells (M2) were also frequent. CD68(+)/iNOS(+) (M1) elements were rare. Mast cells, defined as a population of c-kit (CD117)(+) and/or tryptase(+) cells were also detected...
January 1, 2017: Innate Immunity
https://www.readbyqxmd.com/read/29136691/-tumors-of-lymphoid-and-hematopoietic-tissue-of-spleen-a-clinicopathologic-analysis-of-53-cases
#20
D B Chen, D H Shen, H Zhang, Y Wang, Q J Song, S M Yang, X Z Fang
Objective: To study the clinicopathologic features, diagnosis and differential diagnosis of the tumors of lymphoidand hematopoietic tissue of the spleen(TLTS). Methods: Fifty-three cases of TLTS were selected from the pathologic files from Peking University People's Hospital from April 2002 to April 2017. According to WHO classification of tumors of hematopoietic and lymphoid tissues (2008) and its updated classification (2016), the cases were studied by microscopy, immunohistochemistry and in situ hybridization, combined with the bone marrow biopsy and clinical examination...
November 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
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