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https://www.readbyqxmd.com/read/28319669/cell-adhesion-on-dynamic-supramolecular-surfaces-probed-by-fluid-force-microscopy-based-single-cell-force-spectroscopy
#1
Shrikrishnan Sankaran, Leena Jaatinen, Jenny Brinkmann, Tomaso Zambelli, Janos Vörös, Pascal Jonkheijm
Biomimetic and stimuli-responsive cell-material interfaces are actively being developed to study and control various cell-dynamics phenomena. Since cells naturally reside in the highly dynamic and complex environment of the extracellular matrix, attempts are being made to replicate these conditions in synthetic biomaterials. Supramolecular chemistry, dealing with non-covalent interactions, has recently provided possibilities to incorporate such dynamicity and responsiveness in various types of architectures...
March 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/28319617/biosimilars-in-psoriasis-the-future-or-not
#2
Roselyn Kellen, Gary Goldenberg
As patents for the biologic agents reach their expiration dates, dermatologists must prepare for the coming of biosimilars. These agents have been deemed "highly similar" to their reference products in a process outlined by the US Food and Drug Administration (FDA). In 2016, the FDA approved 3 biosimilars for various indications including plaque psoriasis and psoriatic arthritis. However, biosimilars are not the same as small-molecule generics because they have a complex manufacturing process that makes it impossible to produce identical products to their reference products...
February 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28319592/trends-in-prevalence-awareness-treatment-and-control-of-high-blood-pressure-in-the-seychelles-between-1989-and-2013
#3
Samuel Heiniger, Bharathi Viswanathan, Jude Gedeon, Fred Paccaud, Pascal Bovet
BACKGROUND: Limited data are available in the African region on trends in blood pressure (BP) and awareness, treatment and control rates. OBJECTIVE: We examined trends in these indicators for a 25-year period in the Seychelles, a rapidly developing small island state in the African region. METHODS: Population-based surveys of adults aged 25-64 years were performed in 1989, 1994, 2004 and 2013 using nearly identical methods for all surveys...
March 17, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28319204/responses-to-others-pain-in-adults-with-autistic-traits-the-influence-of-gender-and-stimuli-modality
#4
Jing Meng, Zuoshan Li, Lin Shen
Individuals with autism-spectrum disorder (ASD) exhibit impairments in response to others' pain. Evidence suggests that features of autism are not restricted to individuals with ASD, and that autistic traits vary throughout the general population. To investigate the association between autistic traits and the responses to others' pain in typically developing adults, we employed the Autism-Spectrum Quotient (AQ) to quantify autistic traits in a group of 1670 healthy adults and explored whether 60 participants (30 males and 30 females) with 10% highest AQ scores (High-AQ) would exhibit difficulties in the responses to others' pain relative to 60 participants (30 males and 30 females) with 10% lowest AQ scores (Low-AQ)...
2017: PloS One
https://www.readbyqxmd.com/read/28318413/treatment-strategies-for-programming-and-ritual-abuse
#5
Colin Ross
Individuals in treatment for dissociative identity disorder not uncommonly describe childhood involvement in organized, multi-perpetrator ritual abuse. They described being "programmed" by the perpetrators and feel that the programming is out of their control. The author has developed a set of treatment strategies and interventions for such cases. These are based on the principle of therapeutic neutrality and can be used no matter what assumptions the therapist makes about the historical accuracy of the memories and beliefs...
February 16, 2017: Journal of Trauma & Dissociation
https://www.readbyqxmd.com/read/28318307/stress-socializing-and-other-motivations-for-smoking-among-the-lesbian-gay-bisexual-transgender-and-queer-community-in-new-york-city
#6
Deanna P Jannat-Khah, LeConté J Dill, Simone A Reynolds, Michael A Joseph
PURPOSE: This study contributes to the emerging literature on lesbian, gay, bisexual, transgendered, and queer (LGBTQ) health disparities and tobacco use by examining the motivations for smoking among the New York City (NYC) LGBTQ population. APPROACH: We used grounded theory and blended methods from 3 grounded theorists-Strauss, Corbin, and Charmaz-for data collection, coding, and analysis. SETTING: NYC has extensive legislation to prevent smoking; however, the current smoking prevalence of homosexuals is double that of heterosexuals...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/28318291/consistent-individual-differences-in-standard-exploration-tasks-in-the-black-rat-rattus-rattus
#7
Barbora Žampachová, Barbora Kaftanová, Hana Šimánková, Eva Landová, Daniel Frynta
In a fluctuating environment, the optimal level of exploratory behavior depends on the proportion of current risks and benefits. The exploratory behavior is, therefore, often subjected to heterogenous selection. In populations of commensal rodents living in close proximity of humans, this pressure is further increased by pest management. We hypothesize that the black rat (Rattus rattus) responds to this pressure by either high behavioral flexibility or by development of personality types. The aim of this study was to analyze exploratory behavior and boldness of wild black rats and its changes over time to determine whether exploratory behavior is a personality trait in black rats...
March 20, 2017: Journal of Comparative Psychology
https://www.readbyqxmd.com/read/28318242/whole-blood-metabolomics-by-1h-nmr-spectroscopy-provides-a-new-opportunity-to-evaluate-coenzymes-and-antioxidants
#8
G A Nagana Gowda, Daniel Raftery
Conventional human blood metabolomics employs serum or plasma and provides a wealth of metabolic information therein. However, this approach lacks the ability to measure and evaluate important metabolites such as coenzymes that are present at high concentrations in red blood cells. As an important alternative to serum/plasma metabolomics, we show here that a simple 1H NMR experiment can simultaneously measure coenzymes and antioxidants in extracts of whole human blood, in addition to the nearly 70 metabolites that were shown to be quantitated in serum/plasma, recently [Anal...
March 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28318017/thymic-crosstalk-restrains-the-pool-of-cortical-thymic-epithelial-cells-with-progenitor-properties
#9
Catarina Meireles, Ana R Ribeiro, Rute D Pinto, Catarina Leitão, Pedro M Rodrigues, Nuno L Alves
Cortical (cTEC) and medullary (mTEC) thymic epithelial cells establish key microenvironments for T-cell differentiation and arise from thymic epithelial cell progenitors (TEP). However, the nature of TEPs and the mechanism controlling their stemness in the postnatal thymus remain poorly defined. Using TEC clonogenic assays as a surrogate to survey TEP activity, we found that a fraction of cTECs generates specialized clonal-derived colonies, which contain cells with sustained colony-forming capacity (ClonoTECs)...
March 20, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28318013/ethnic-identity-development-and-acculturation-preferences-among-minority-and-majority-youth-norms-and-contact
#10
Roberto González, Brian Lickel, Manisha Gupta, Linda R Tropp, Bernadette P Luengo Kanacri, Eduardo Mora, Pablo De Tezanos-Pinto, Christian Berger, Daniel Valdenegro, Oscar Cayul, Daniel Miranda, Patricio Saavedra, Michelle Bernardino
This article tests a longitudinal model of the antecedents and consequences of changes in identification with indigenous (Mapuche) among indigenous and nonindigenous youth in Chilean school contexts over a 6-month period (633 nonindigenous and 270 Mapuche students, Mages  = 12.47 and 12.80 years, respectively). Results revealed that in-group norms supporting contact and quality of intergroup contact at Time 1 predicted student's changes in Mapuche identification at Time 2, which in turn predicted changes in support for adoption of Chilean culture and maintenance of Mapuche culture at Time 2; some of the relationships between these variables were found to be moderated by age and ethnicity...
March 20, 2017: Child Development
https://www.readbyqxmd.com/read/28317938/on-the-determination-of-%C3%AF-2-in-thin-films-a-comparison-of-one-beam-second-harmonic-generation-measurement-methodologies
#11
Artur Hermans, Clemens Kieninger, Kalle Koskinen, Andreas Wickberg, Eduardo Solano, Jolien Dendooven, Martti Kauranen, Stéphane Clemmen, Martin Wegener, Christian Koos, Roel Baets
The determination of the second-order susceptibility (χ((2))) of thin film samples can be a delicate matter since well-established χ((2)) measurement methodologies such as the Maker fringe technique are best suited for nonlinear materials with large thicknesses typically ranging from tens of microns to several millimeters. Here we compare two different second-harmonic generation setups and the corresponding measurement methodologies that are especially advantageous for thin film χ((2)) characterization. This exercise allows for cross-checking the χ((2)) obtained for identical samples and identifying the main sources of error for the respective techniques...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28316260/animal-physiology-and-genetic-aspects-of-ryegrass-staggers-in-grazing-sheep
#12
C A Morris, T T Wheeler, H V Henderson, N R Towers, S H Phua
Ryegrass staggers (RGS) is a metabolic disease of herbivores, caused by the ingestion of perennial ryegrass (Lolium perenne L.) containing a fungal endophyte (Neotyphodium lolii) which produces a tremorgenic toxin, lolitrem B. RGS has a major economic impact for agriculture in New Zealand as well as internationally. Management of RGS in grazing sheep can be problematic, and there is an incomplete knowledge of the interaction between the toxin and the grazing animal. This review is focused on recent advances in understanding the molecular physiology of RGS in the affected animal as well as the influence of animal genetics on the degree of susceptibility to RGS...
March 19, 2017: New Zealand Veterinary Journal
https://www.readbyqxmd.com/read/28315589/the-multidimensional-card-selection-task-a-new-way-to-measure-concurrent-cognitive-flexibility-in-preschoolers
#13
Gal Podjarny, Deepthi Kamawar, Katherine Andrews
Most executive function research examining preschoolers' cognitive flexibility, the ability to think about something in more than one way, has focused on preschoolers' facility for sequentially switching their attention from one dimension to another (e.g., sorting bivalent cards first by color and then by shape). We know very little about preschoolers' ability to coordinate more than one dimension simultaneously (concurrent cognitive flexibility). Here we report on a new task, the Multidimensional Card Selection Task, which was designed to measure children's ability to consider two dimensions, and then three dimensions, concurrently (e...
March 15, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28315422/sfpq-psf-tfe3-renal-cell-carcinoma-rcc-a-clinicopathologic-study-emphasizing-extended-morphology-and-reviewing-the-differences-between-sfpq-tfe3-rcc-and-the-corresponding-mesenchymal-neoplasm-despite-an-identical-gene-fusion
#14
Xiao-Tong Wang, Qiu-Yuan Xia, Hao Ni, Sheng-Bing Ye, Rui Li, Xuan Wang, Shan-Shan Shi, Xiao-Jun Zhou, Qiu Rao
Xp11 translocation renal cell carcinoma (RCC) with SFPQ/PSF-TFE3 gene fusion is a rare epithelial tumor. Of note, the appearance of the gene fusion does not necessarily mean that it is renal cell carcinoma. The corresponding mesenchymal neoplasms, including Xp11 neoplasm with melanocytic differentiation, TFE3 rearrangement-associated perivascular epithelioid cell tumor (PEComa) and melanotic Xp11 translocation renal cancer, can also harbor the identical gene fusion. However, the differences between Xp11 translocation RCC and the corresponding mesenchymal neoplasm have only recently been described...
March 14, 2017: Human Pathology
https://www.readbyqxmd.com/read/28314455/multicultural-developmental-experiences-implications-for-resilience-in-transitional-age-youth
#15
REVIEW
Deborah Rivas-Drake, Gabriela Livas Stein
Transitional age youth were born into a world that is becomingly increasingly diverse. Youth who are ethnic or racial minorities encounter cultural stressors, including acculturative stress and discrimination that undermine their health and mental health. Decades of research demonstrate that cultural assets can serve as risk-reducing and resilience-enhancing mechanisms among minority and immigrant youth. Cultural assets include the development of a healthy ethnic-racial identity and maintenance of cultural values...
April 2017: Child and Adolescent Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/28314219/supplemental-description-of-nyctotheroides-pyriformis-n-comb-macrocytopharynxa-pyriformis-nie-1932-li-et-al-2002-from-frog-hosts-with-consideration-of-the-validity-of-the-genus-macrocytopharynxa-armophorea-clevelandellida
#16
Ming Li, Can Li, J Norman Grim, Francisco Ponce-Gordo, Guitang Wang, Hong Zou, Wenxiang Li, Shangong Wu
The morphological revisions of Macrocytopharynxa pyriformis (Nie, 1932) Li et al., 2002; collected from the rectum of Fejervarya limnocharis (=Rana limnocharis), are presented in this paper: (1) two surfaces of the organism are not identical - left side narrower and convex, right broader and flat or slightly concave; (2) infundibulum is large and well-developed with no "fold" or "plicature" present in the middle or posterior portion; (3) micronucleus is tiny and ovoid shaped and always embedded in the middle concavity of macronucleus, which can be well revealed by ammoniacal silver staining...
October 12, 2016: European Journal of Protistology
https://www.readbyqxmd.com/read/28314074/better-understanding-of-homologous-recombination-through-a-12-week-laboratory-course-for-undergraduates-majoring-in-biotechnology
#17
Ming Li, Xiaodong Shen, Yan Zhao, Xiaomei Hu, Fuquan Hu, Xiancai Rao
Homologous recombination, a central concept in biology, is defined as the exchange of DNA strands between two similar or identical nucleotide sequences. Unfortunately, undergraduate students majoring in biotechnology often experience difficulties in understanding the molecular basis of homologous recombination. In this study, we developed and implemented a 12-week laboratory course for biotechnology undergraduates in which gene targeting in Streptococcus suis was used to facilitate their understanding of the basic concept and process of homologous recombination...
March 17, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28304245/kineothrix-alysoides-gen-nov-sp-nov-a-saccharolytic-butyrate-producer-within-the-family-lachnospiraceae
#18
Kelly Nicole Haas, Jeffrey L Blanchard
An anaerobic, saccharolytic, spore-forming, butyrate-producing bacterium, strain KNHs209T, was isolated from a switchgrass microcosm seeded with forest soil. Cells were highly motile rods, often forming long filamentous chains which were easily observed moving under the microscope. Its closest phylogenetic relative was Eisenbergiella tayi (16S rRNA gene sequence identity 94.2 %), although it was easily distinguishable based on its morphology and physiology. Whole-genome sequencing enabled development of a minimal medium, and also suggested that the organism is capable of fixing nitrogen...
February 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28304110/perceptions-of-health-among-black-adults-living-in-a-diverse-urban-community
#19
Dahnika Sachs, Jill N Peltzer, Jerrihlyn L McGee
OBJECTIVE: The Robert Wood Johnson Foundation's culture of health initiative advocates for making health a shared value. Health cannot be a shared value without an understanding of how health is defined and perceived. The purpose of this qualitative descriptive study was to examine community members' perceptions of health and influencing factors, including health care services. DESIGN AND SAMPLE: Data were collected through a purposive sample of nine focus groups with 52 participants who were primarily Black (94%) and female (65%)...
March 17, 2017: Public Health Nursing
https://www.readbyqxmd.com/read/28303796/rapid-structural-analysis-of-nanomaterials-in-aqueous-solutions
#20
Sou Ryuzaki, Makusu Tsutsui, Yuhui He, Kazumichi Yokota, Akihide Arima, Takanori Morikawa, Masateru Taniguchi, Tomoji Kawai
Rapid structural analysis of nanoscale matter in a liquid environment represents innovative technologies that reveal the identities and functions of biologically important molecules. However, there is currently no method with high spatio-temporal resolution that can scan individual particles in solutions to gain structural information. Here we report the development of a nanopore platform realizing quantitative structural analysis for suspended nanomaterials in solutions with a high z-axis and xy-plane spatial resolution of 35...
April 18, 2017: Nanotechnology
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