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https://www.readbyqxmd.com/read/28335560/serum-amyloid-a-production-is-triggered-by-sleep-deprivation-in-mice-and-humans-is-that-the-link-between-sleep-loss-and-associated-comorbidities
#1
Edson M de Oliveira, Bruna Visniauskas, Sergio Tufik, Monica L Andersen, Jair R Chagas, Ana Campa
Serum amyloid A (SAA) was recently associated with metabolic endotoxemia, obesity and insulin resistance. Concurrently, insufficient sleep adversely affects metabolic health and is an independent predisposing factor for obesity and insulin resistance. In this study we investigated whether sleep loss modulates SAA production. The serum SAA concentration increased in C57BL/6 mice subjected to sleep restriction (SR) for 15 days or to paradoxical sleep deprivation (PSD) for 72 h. Sleep restriction also induced the upregulation of Saa1...
March 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28323628/effects-of-bach-flower-remedies-on-menopausal-symptoms-and-sleep-pattern-a-case-report
#2
Marcele Siegler, Cristina Frange, Monica Levy Andersen, Sergio Tufik, Helena Hachul
Context • During the postmenopausal stage, women go through many remarkable changes, including physical, emotional, and hormonal. They also experience some unwanted effects, such as vasomotor symptoms, anxiety, and insomnia. The use of Bach flower remedies has been described as a supporting therapy for those symptoms. Objectives • The investigation aimed to evaluate the effects of the supplement on sleep pattern (ie, sleep perception and objective sleep) and on menopausal symptoms. Design • The research team created a case report...
March 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28266947/to-the-editor
#3
Carolina Vicente Banzoli, Andréia Gomes Bezerra, Sergio Tufik, Helena Hachul
No abstract text is available yet for this article.
March 6, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28223243/on-the-verge-of-a-respiratory-type-panic-attack-selective-activations-of-rostrolateral-and-caudoventrolateral-periaqueductal-gray-matter-following-short-lasting-escape-to-a-low-dose-of-potassium-cyanide
#4
Cláudia Janaina Torres Müller, Jeyce Willig Quintino-Dos-Santos, Fagna Giacomin Schimitel, Sérgio Tufik, Vanessa Beijamini, Newton Sabino Canteras, Luiz Carlos Schenberg
Intravenous injections of potassium cyanide (KCN) both elicit escape by its own and facilitate escape to electrical stimulation of the periaqueductal gray matter (PAG). Moreover, whereas the KCN-evoked escape is potentiated by CO2, it is suppressed by both lesions of PAG and clinically effective treatments with panicolytics. These and other data suggest that the PAG harbors a hypoxia-sensitive alarm system the activation of which could both precipitate panic and render the subject hypersensitive to CO2. Although prior c-Fos immunohistochemistry studies reported widespread activations of PAG following KCN injections, the employment of repeated injections of high doses of KCN (>60µg) in anesthetized rats compromised both the localization of KCN-responsive areas and their correlation with escape behavior...
February 20, 2017: Neuroscience
https://www.readbyqxmd.com/read/28216961/menopausal-symptoms-and-obesity-is-there-a-relationship
#5
Maria Fernanda Naufel, Cristina Frange, Sérgio Tufik, Helena Hachul
No abstract text is available yet for this article.
October 2016: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28215251/the-association-between-caffeine-consumption-and-objective-sleep-variables-is-dependent-on-adora2a-c-1083t-c-genotypes
#6
Rafael Almeida Nunes, Diego Robles Mazzotti, Camila Hirotsu, Monica L Andersen, Sergio Tufik, Lia Bittencourt
OBJECTIVE: To verify the association between c.1083T>C polymorphism in the adenosine receptor A2A gene (ADORA2A) and objective sleep, as well as the correlation between caffeine consumption, sleep parameters, and electroencephalographic spectral power in a large, population-based sample from São Paulo, Brazil. METHODS: This study was conducted in participants of the São Paulo Epidemiologic Sleep Study (EPISONO), a large, population-based survey consisting of a representative sample of the inhabitants of the city from São Paulo, Brazil, according to sex, age (20-80 years), and socioeconomic status in the year 2007...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28181838/physical-activity-questionnaires-do-not-accurately-estimate-fitness-in-older-women
#7
Aurora de Fátima Cabral, Marcelo M Pinheiro, Charlles Hm Castro, Marco Túlio de Mello, Sergio Tufik, Vera L Szejnfeld
OBJECTIVE: To compare the performance of International Physical Activity Questionnaire - IPAQ and Baecke questionnaire to estimate maximal oxygen uptake (VO2max) in healthy older women. METHODS: One hundred healthy women aged 60 years and older answered the IPAQ and Baecke questionnaires and underwent cardiopulmonary exercise test. Six-minute walk (6MWT), Timed up and go (TUG) and handgrip strength test (HST) were also performed. RESULTS: Mean age and body mass index were 68...
February 9, 2017: Journal of Aging and Physical Activity
https://www.readbyqxmd.com/read/28123648/effectiveness-of-maxillomandibular-advancement-mma-surgery-in-sleep-apnea-treatment-case-report
#8
Otávio Ferraz, Thais M Guimarães, Rowdley R Rossi, Paulo A Cunali, Cibele Dal Fabbro, Cauby M Chaves, Milton Maluly, Lia Bittencourt, Sergio Tufik
Obstructive sleep apnea (OSA) is characterized by episodes of pharyngeal collapse during sleep. Craniofacial alterations such as retrognathia are often found in OSA patients. Maxillomandibular advancement (MMA) surgeries increase the pharyngeal space and are a treatment option for OSA. The aim of this study was to present a successful case of MMA surgery in the treatment of OSA. A patient with moderate OSA (apnea-hypopnea index (AHI)=25.2) and mandibular retrognathism and Maxillomandibular asymmetry underwent MMA surgery...
July 2016: Sleep Science
https://www.readbyqxmd.com/read/28123647/phenotypic-contrasts-of-duchenne-muscular-dystrophy-in-women-two-case-reports
#9
Karen T Nozoe, Ricardo T Akamine, Diego R Mazzotti, Daniel N Polesel, Luís F Grossklauss, Sergio Tufik, Monica L Andersen, Gustavo A Moreira
We discussed two cases of symptomatic female carriers to Duchenne Muscular Dystrophy. The first case is a 20 year-old girl with classical phenotypic manifestation of the disease, similar to the condition in boys. The case 2 is a 62 year-old woman with progressive muscular weakness. The disease is much less common in woman than men so both cases described here are considered rare forms of the disease, with several clinical implications. In both cases, a progressive muscle weakness, impairment in walking and sleeping was observed, in addition to obstructive sleep apnea syndrome and alveolar hypoventilation, that required noninvasive ventilatory support...
July 2016: Sleep Science
https://www.readbyqxmd.com/read/28121915/moderate-exercise-increases-endotoxin-concentration-in-hypoxia-but-not-in-normoxia-a-controlled-clinical-trial
#10
RANDOMIZED CONTROLLED TRIAL
Paola Machado, Aline Caris, Samile Santos, Edgar Silva, Lila Oyama, Sergio Tufik, Ronaldo Santos
BACKGROUND: Hypoxia and high altitudes affect various organs, which impairs important physiological functions, such as a disruption of the intestinal barrier mediated by increased translocation of bacteria and increased circulating endotoxin levels. Physical exercise can alter endotoxin concentration in normoxia. The aim of this study is to evaluate the effects of moderate exercise on endotoxin concentration in normobaric hypoxia. METHODS: Nine healthy male volunteers exercised on a treadmill for 60 minutes at an intensity of 50% VO2peak in normoxic or hypoxic conditions (4200 m)...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28116804/gabapentin-acutely-increases-the-apnea-hypopnea-index-in-older-men-data-from-a-randomized-double-blind-placebo-controlled-study
#11
Ronaldo D Piovezan, Camila Kase, Renato Moizinho, Sergio Tufik, Dalva Poyares
Although drugs with sedative properties may increase the risk of airway collapse during sleep, their acute effects on the apnea-hypopnea index in older adults are under-reported. We investigated the acute effects of gabapentin (GABA) on sleep breathing in older men without sleep apnea. A double-blind, randomized, placebo-controlled cross-over pilot study using a bedtime dose of gabapentin 300 mg was conducted in eight non-obese older men. Polysomnography measured the effects of the intervention. The apnea-hypopnea index was higher in the gabapentin arm than in the placebo arm (22...
January 24, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28110177/effects-of-localized-versus-widespread-tmd-pain-on-sleep-parameters-in-patients-with-bruxism-a-single-night-polysomnographic-study
#12
José Tadeu Tesseroli de Siqueira, Cinara Maria Camparis, Silvia Regina Dowgan Tesseroli de Siqueira, Manoel Jacobsen Teixeira, Lia Bittencourt, Sérgio Tufik
OBJECTIVE: The purpose of this study was to investigate whether the presence of concomitant widespread pain could influence the polysomnographic characteristics of patients with Sleep Bruxism(SB) and chronic masticatory muscle pain(TMD). METHODS: 20 SB/TMD patients (17 women and 3 men) were evaluated according to the RDC/TMD questionnaire; and were divided into two groups according to the absence (Group A) or presence (Group B) of widespread pain. They were evaluated in a one night polysomnography paradigm...
January 16, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28076650/chronotype-and-anxiety-are-associated-in-patients-with-chronic-primary-insomnia
#13
Giselle S Passos, Marcos G Santana, Dalva Poyares, Carolina V D'Aurea, Alexandre A Teixeira, Sergio Tufik, Marco T de Mello
Objective: To assess the interaction of chronotype with anxiety in patients with chronic primary insomnia. Methods: Sixty-four patients (50 women) with mean age 43.9±8.1 years were investigated with the Horne and Östberg Morningness-Eveningness Questionnaire (MEQ) and State-Trait Anxiety Inventory (STAI). Results: Significant negative correlations of chronotype-MEQ score with STAI state-anxiety (r = -0.40, p < 0.05), STAI trait-anxiety (r = -0...
January 9, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28069386/sleep-influences-the-immune-response-and-the-rejection-process-alters-sleep-pattern-evidence-from-a-skin-allograft-model-in-mice
#14
Francieli Silva Ruiz, Monica Levy Andersen, Camila Guindalini, Leandro Pires Araujo, José Daniel Lopes, Sergio Tufik
INTRODUCTION: Sleep generally regulates immune functions in a supportive manner and can affect parameters that are directly involved in the rejection process. STUDY OBJECTIVES: The first objective was to assess whether sleep deprivation (SD) or sleep restriction (SR) affects the allograft rejection process in mice. The second objective was to investigate whether the rejection process itself modulates the sleep pattern of allografted mice. DESIGN: Adult BALB/c and C57BL/6J male mice were used as the donors and recipients, respectively, except for the syngeneic group (ISOTX), which received skin from mice of the same strain (C57BL/6J)...
January 7, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28007359/neurocognitive-function-in-patients-with-residual-excessive-sleepiness-from-obstructive-sleep-apnea-a-prospective-controlled-study
#15
Ksdy S Werli, Leonardo J Otuyama, Paulo H Bertolucci, Camila F Rizzi, Christian Guilleminault, Sergio Tufik, Dalva Poyares
OBJECTIVE: This study aimed to evaluate neurocognitive function in adult patients with residual excessive sleepiness (RES) after appropriate treatment of obstructive sleep apnea (OSA) with CPAP and good adherence to treatment. METHODS: This was a prospective controlled study. We included patients of both sexes, aged 35-60 years with OSA and an apnea-hypopnea index >20 ev/h, effectively treated with CPAP, but with a residual Epworth Sleepiness Scale score ≥11...
October 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27913971/myofunctional-therapy-improves-adherence-to-continuous-positive-airway-pressure-treatment
#16
Giovana Diaféria, Rogerio Santos-Silva, Eveli Truksinas, Fernanda L M Haddad, Renata Santos, Silvana Bommarito, Luiz C Gregório, Sergio Tufik, Lia Bittencourt
PURPOSE: Few studies have investigated myofunctional therapy in patients with obstructive sleep apnea syndrome (OSAS). The objective of this study was to evaluate the effect of myofunctional therapy on continuous positive airway pressure (CPAP) adherence. METHODS: The study was registered at ClinicalTrials.gov (NCT01289405). Male patients with OSAS were randomly divided into four treatment groups: placebo, patients undergoing placebo myofunctional therapy (N = 24); myofunctional therapy, undergoing myofunctional therapy (N = 27); CPAP, undergoing treatment with CPAP (N = 27); and combined, undergoing CPAP therapy and myofunctional therapy (N = 22)...
December 2, 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/27901185/applicability-of-predictive-equations-for-resting-energy-expenditure-in-obese-patients-with-obstructive-sleep-apnea
#17
Mariana Pantaleão Del Re, Camila Maria de Melo, Marcus Vinicius Dos Santos, Sergio Tufik, Marco Túlio de Mello
Objective: To investigate the applicability of predictive equations for resting energy expenditure (REE) in obese individuals with obstructive sleep apnea (OSA) and the effects of OSA severity on REE. Materials and methods: Twenty-nine obese men, 41.5 ± 7 years old, with moderate and severe OSA were recruited. All subjects were submitted to a clinical polysomnography, body composition, and indirect calorimetry measurements. REE was also predicted by three different equations: Harris and Benedict (1919), Cunningham (1990), and DRI (2002)...
November 24, 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27880816/paradoxical-sleep-deprivation-causes-cardiac-dysfunction-and-the-impairment-is-attenuated-by-resistance-training
#18
Sara Quaglia de Campos Giampá, Marcos Mônico-Neto, Marco Tulio de Mello, Helton de Sá Souza, Sergio Tufik, Kil Sun Lee, Marcia Kiyomi Koike, Alexandra Alberta Dos Santos, Ednei Luiz Antonio, Andrey Jorge Serra, Paulo José Ferreira Tucci, Hanna Karen Moreira Antunes
BACKGROUND: Paradoxical sleep deprivation activates the sympathetic nervous system and the hypothalamus-pituitary-adrenal axis, subsequently interfering with the cardiovascular system. The beneficial effects of resistance training are related to hemodynamic, metabolic and hormonal homeostasis. We hypothesized that resistance training can prevent the cardiac remodeling and dysfunction caused by paradoxical sleep deprivation. METHODS: Male Wistar rats were distributed into four groups: control (C), resistance training (RT), paradoxical sleep deprivation for 96 hours (PSD96) and both resistance training and sleep deprivation (RT/PSD96)...
2016: PloS One
https://www.readbyqxmd.com/read/27827949/carbohydrate-supplementation-influences-serum-cytokines-after-exercise-under-hypoxic-conditions
#19
Aline Venticinque Caris, Edgar Tavares Da Silva, Samile Amorim Dos Santos, Fabio Santos Lira, Lila Missae Oyama, Sergio Tufik, Ronaldo Vagner Thomatieli Dos Santos
INTRODUCTION: Exercise performed at the hypoxia equivalent of an altitude of 4200 m is associated with elevated inflammatory mediators and changes in the Th1/Th2 response. By contrast, supplementation with carbohydrates has an anti-inflammatory effect when exercise is performed under normoxic conditions. The objective of this study was to evaluate the effect of carbohydrate supplementation on cytokines and cellular damage markers after exercise under hypoxic conditions at a simulated altitude of 4200 m...
November 5, 2016: Nutrients
https://www.readbyqxmd.com/read/27810176/effects-of-acute-sleep-deprivation-on-state-anxiety-levels-a-systematic-review-and-meta-analysis
#20
REVIEW
Gabriel Natan Pires, Andreia Gomes Bezerra, Sergio Tufik, Monica Levy Andersen
Increased anxiety levels have been widely recognized as one of the most important consequences of sleep deprivation. However, despite this general consensus, there are still aspects of this relationship, such as the extent of the anxiogenic potential and the specific effects of different types of sleep deprivation, which remain unclear. As no broad review has been undertaken to evaluate this relationship, we performed a systematic review and meta-analysis regarding the effects of sleep deprivation on state anxiety...
August 2016: Sleep Medicine
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