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https://www.readbyqxmd.com/read/28726005/the-role-of-sleep-in-pemphigus-a-review-of-mechanisms-and-perspectives
#1
Matheus Negrao Pedroni, Camila Hirotsu, Adriana Maria Porro, Sergio Tufik, Monica Levy Andersen
Pemphigus is an autoimmune bullous disease that causes the development of blisters and erosions on the skin and/or mucosa. Its inflammatory process is mediated by cytokines, which interact with sleep in a bidirectional manner. Pain, a frequent symptom due to pemphigus lesions, is well known to impair sleep quality. Depression is also associated with pemphigus and pro-inflammatory cytokines and may impair sleep. Additionally, a common relationship among other dermatological diseases and sleep has increasingly been described...
July 19, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28690872/physiological-and-lipid-profile-response-to-acute-exercise-at-different-intensities-in-individuals-with-spinal-cord-injury
#2
Eduardo S Alves, Ronaldo Vt Santos, Francieli S Ruiz, Fabio S Lira, Alexandre A Almeida, Giscard Lima, Thatiana Cs Goni, Lila Oyama, Kate M Edwards, Sergio Tufik, Marco Túlio De Mello
STUDY DESIGN: Experimental and cross-sectional study. OBJECTIVE: To assess the immediate effect of exercise on heart rate (HR), oxygen uptake (VO2), pulmonary ventilation (PV), oxygen pulse (OP), glucose and lipids of wheelchair basketball players with spinal cord injury (SCI). SETTING: Center of Studies in Psychobiology and Exercise-São Paulo, Brazil. METHODS: In all, nine wheelchair basketball players with SCI and nine able-bodied controls (C) performed three exercise sessions at different intensities: ventilatory threshold 1 (VT1), 15% below VT1 and 15% above VT1 with a duration of ~24-34 min...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28686746/obstructive-sleep-apnea-and-objective-short-sleep-duration-are-independently-associated-with-the-risk-of-serum-vitamin-d-deficiency
#3
Ronaldo D Piovezan, Camila Hirotsu, Marcia C Feres, Fatima D Cintra, Monica L Andersen, Sergio Tufik, Dalva Poyares
BACKGROUND: Studies demonstrate an association between vitamin D (25(OH)D) deficiency and sleep disturbances, such as obstructive sleep apnea (OSA) and short sleep duration. However, to date, no studies have concurrently and objectively evaluated the effect of these factors on 25(OH)D. OBJECTIVES: To evaluate whether OSA and objective short sleep duration are independently associated with reduced 25(OH)D in an adult population sample. METHODS: A cross-sectional study included 657 individuals from the city of Sao Paulo, Brazil, as part of the ERA project...
2017: PloS One
https://www.readbyqxmd.com/read/28671626/effects-of-carbohydrate-and-glutamine-supplementation-on-oral-mucosa-immunity-after-strenuous-exercise-at-high-altitude-a-double-blind-randomized-trial
#4
Aline Venticinque Caris, Edgar Tavares Da Silva, Samile Amorim Dos Santos, Sergio Tufik, Ronaldo Vagner Thomatieli Dos Santos
This study analyzed the effects of carbohydrate and glutamine supplementation on salivary immunity after exercise at a simulated altitude of 4500 m. Fifteen volunteers performed exercise of 70% of VO2peak until exhaustion and were divided into three groups: hypoxia placebo, hypoxia 8% maltodextrin (200 mL/20 min), and hypoxia after six days glutamine (20 g/day) and 8% maltodextrin (200 mL/20 min). All procedures were randomized and double-blind. Saliva was collected at rest (basal), before exercise (pre-exercise), immediately after exercise (post-exercise), and two hours after exercise...
July 3, 2017: Nutrients
https://www.readbyqxmd.com/read/28643460/periodic-limb-movement-in-sleep-and-sickle-cell-disease-a-neglected-association
#5
Ana C Cabañas-Pedro, Suely Roizenblatt, Altay A L de Souza, Sérgio Tufik, Maria S Figueiredo
High frequency of periodic limb movements in sleep (PLMS) has been described among children with sickle cell disease (SCD), but there is little information about PLMS among adults with SCD. We aim to determine the frequency of PLMS among adults with SCD and to identify possible associations with iron status and haemolytic parameters. We analysed polysomnography on 99 adults: 74 with sickle cell anaemia (HbSS), 19 with HbSC (double heterozygosis HbS and HbC) and 6 with HbS-beta thalassaemia. Laboratory data were collected close to the time of the polysomnography examination...
June 23, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28536294/the-interfaces-between-vitamin-d-sleep-and-pain
#6
REVIEW
Daniela Leite de Oliveira, Camila Hirotsu, Sergio Tufik, Monica Levy Andersen
The role of vitamin D in osteomineral metabolism is well known. Several studies have suggested its action on different biological mechanisms, such as nociceptive sensitivity and sleep-wake cycle modulation. Sleep is an important biological process regulated by different regions of the central nervous system, mainly the hypothalamus, in combination with several neurotransmitters. Pain, which can be classified as nociceptive, neuropathic and psychological, is regulated by both the central and peripheral nervous systems...
July 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28504003/different-metabolic-responses-induced-by-long-term-interdisciplinary-therapy-in-obese-adolescents-related-to-ace-i-d-polymorphism
#7
Sandro S Almeida, Flavia C Corgosinho, Carlos En Amorim, Marcos F Gregnani, Raquel Ms Campos, Deborah Cl Masquio, Priscila L Sanches, Aline P Ganen, João B Pesquero, Ana R Dâmaso, Marco T Mello, Sergio Tufik, Ronaldo C Araújo
INTRODUCTION: The main purpose of the present study was to investigate whether I/D polymorphism of the ACE gene might affect metabolic changes related to the metabolic syndrome through a long-term interdisciplinary therapy in obese adolescents. METHODS: In total, 125 obese adolescents who entered the interdisciplinary obesity programme were assigned to the following two subgroups: metabolic syndrome or non-metabolic syndrome. They were evaluated at baseline and after 1 year...
April 2017: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://www.readbyqxmd.com/read/28502283/why-should-we-care-about-selenium-in-obstructive-sleep-apnea
#8
Rachel Gimenes Albuquerque, Camila Hirotsu, Sergio Tufik, Monica Levy Andersen
No abstract text is available yet for this article.
July 15, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28499899/the-wake-promoting-drug-modafinil-prevents-motor-impairment-in-sickness-behavior-induced-by-lps-in-mice-role-for-dopaminergic-d1-receptor
#9
Adriano Zager, Wesley Nogueira Brandão, Rafael Oliveira Margatho, Jean Pierre Peron, Sergio Tufik, Monica Levy Andersen, Birgitte Rahbek Kornum, João Palermo-Neto
The wake-promoting drug Modafinil has been used for many years for treatment of Narcolepsy and Excessive Daytime Sleepiness, due to a dopamine-related psychostimulant action. Recent studies have indicated that Modafinil prevents neuroinflammation in animal models. Thus, the aim of the present study was to evaluate the effect of Modafinil pretreatment in the Lipopolysaccharide (LPS)-induced sickness and depressive-like behaviors. Adult male C57BL/6J mice were pretreated with Vehicle or Modafinil (90mg/Kg) and, 30min later, received a single saline or LPS (2mg/Kg) administration, and were submitted to the open field and elevated plus maze test 2h later...
May 9, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28495376/gabaa-receptor-positive-allosteric-modulators-modify-the-abuse-related-behavioral-and-neurochemical-effects-of-methamphetamine-in-rhesus-monkeys
#10
Laís F Berro, Monica L Andersen, Sergio Tufik, Leonard L Howell
GABAA receptor positive allosteric modulators (GABAA receptor modulators) are commonly used for the treatment of insomnia. Nevertheless, the effects of these compounds on psychostimulant-induced sleep impairment are poorly understood. Because GABAA receptor modulators have been shown to decrease the abuse-related effects of psychostimulants, the aim of the present study was to evaluate the effects of temazepam (0.3, 1.0 or 3.0 mg/kg) and eszopiclone (0.3, 1.0 or 3.0 mg/kg), two GABAA receptor modulators, on the behavioral neuropharmacology of methamphetamine in adult rhesus macaques (n = 5)...
September 1, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28487661/commentary-stress-signal-network-between-hypoxia-and-er-stress-in-chronic-kidney-disease
#11
COMMENT
Priscila F Tempaku, Sergio Tufik, Camila Hirotsu
No abstract text is available yet for this article.
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28426387/characterization-of-bimodal-chronotype-and-its-association-with-sleep-a-population-based-study
#12
Priscila Farias Tempaku, Juliana Ramirez Arruda, Diego Robles Mazzotti, Bruno S B Gonçalves, Mário Pedrazzoli, Lia Bittencourt, Sergio Tufik
The circadian system coordinates internal events in a daily schedule to make sure that the body systems are synchronized to environmental time and internal cues. One important behavioral aspect of the circadian system is the chronotype. It is usually assessed through subjective questionnaires, being the Horne-Ostberg Morningness-Eveningness Questionnaire (MEQ) one of the most used. It classifies individuals into three major categories: morning, evening, and intermediate types. Recently, it has been hypothesized the existence of a fourth chronotype, the bimodal type, through an algorithm derived from the MEQ responses...
2017: Chronobiology International
https://www.readbyqxmd.com/read/28415893/rem-sleep-deprivation-impairs-muscle-regeneration-in-rats
#13
Marcos Mônico-Neto, Murilo Dáttilo, Daniel Araki Ribeiro, Kil Sun Lee, Marco Túlio de Mello, Sergio Tufik, Hanna Karen Moreira Antunes
INTRODUCTION: The aim was observe the influence of sleep deprivation (SD) and sleep recovery on muscle regeneration process in rats submitted to cryolesion. METHODS: Thirty-two Wistar rats were randomly allocated in four groups: control (CTL), SD for 96 h (SD96), control plus sleep recovery period (CTL + R) and SD96h plus 96 h of sleep recovery (SD96 + R). The animals were submitted to muscle injury by cryolesioning, after to SD and sleep recovery. RESULTS: The major outcomes of this study were the reduction of muscular IGF-1 in both legs (injured and uninjured) and a delay in muscle regeneration process of animals submitted to SD compared to animals that slept, with increase connective tissue, inflammatory infiltrate and minor muscle fibers...
February 2017: Growth Factors
https://www.readbyqxmd.com/read/28394943/sleep-continuity-is-positively-correlated-with-sleep-duration-in-laboratory-nighttime-sleep-recordings
#14
Akifumi Kishi, Hans P A Van Dongen, Benjamin H Natelson, Amy M Bender, Luciana O Palombini, Lia Bittencourt, Sergio Tufik, Indu Ayappa, David M Rapoport
Sleep duration varies widely across individuals and appears to be trait-like. Differences in the stability of underlying sleep processes may underlie this phenomenon. To investigate underlying mechanisms, we examined the relationship between sleep duration and sleep continuity in baseline polysomnography (PSG) recordings from three independently collected datasets: 1) 134 healthy controls (ages 37 ± 13 years) from the São Paulo Epidemiologic Sleep Study, who spent one night in a sleep laboratory, 2) 21 obstructive sleep apnea (OSA) patients who were treated with continuous positive airway pressure for at least 2 months (45 ± 12 years, respiratory disturbance index <15), who spent one night in a sleep laboratory with previous experience of multiple PSG studies, and 3) 62 healthy controls (28 ± 6 years) who, as part of larger experiments, spent 2 consecutive nights in a sleep laboratory...
2017: PloS One
https://www.readbyqxmd.com/read/28366322/sleep-pattern-and-spectral-analysis-of-caregiver-mothers-of-sons-with-duchenne-muscular-dystrophy-and-an-examination-of-differences-between-carriers-and-non-carriers
#15
Karen Tieme Nozoe, Lenise Jihe Kim, Daniel Ninello Polesel, Camila Hirotsu, Altay Lino de Souza, Helena Hachul, Sergio Brasil Tufik, Sergio Tufik, Monica Levy Andersen, Gustavo Antônio Moreira
OBJECTIVES: Sleep is essential for physical and mental well-being. However, poor sleep is a common complaint among caregivers. The aim of the present study was to determine sleep patterns of caregiver-mothers (CM group) of sons with Duchenne muscular dystrophy (DMD) and also to examine the differences between non-carriers and carriers of the gene related to DMD within the CM group. METHODS: Observational case-control study. PARTICIPANTS: The CM and control (CTRL) groups were matched for age, body mass index and social class...
April 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28335560/serum-amyloid-a-production-is-triggered-by-sleep-deprivation-in-mice-and-humans-is-that-the-link-between-sleep-loss-and-associated-comorbidities
#16
Edson M de Oliveira, Bruna Visniauskas, Sergio Tufik, Monica L Andersen, Jair R Chagas, Ana Campa
Serum amyloid A (SAA) was recently associated with metabolic endotoxemia, obesity and insulin resistance. Concurrently, insufficient sleep adversely affects metabolic health and is an independent predisposing factor for obesity and insulin resistance. In this study we investigated whether sleep loss modulates SAA production. The serum SAA concentration increased in C57BL/6 mice subjected to sleep restriction (SR) for 15 days or to paradoxical sleep deprivation (PSD) for 72 h. Sleep restriction also induced the upregulation of Saa1...
March 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28323628/effects-of-bach-flower-remedies-on-menopausal-symptoms-and-sleep-pattern-a-case-report
#17
Marcele Siegler, Cristina Frange, Monica Levy Andersen, Sergio Tufik, Helena Hachul
Context • During the postmenopausal stage, women go through many remarkable changes, including physical, emotional, and hormonal. They also experience some unwanted effects, such as vasomotor symptoms, anxiety, and insomnia. The use of Bach flower remedies has been described as a supporting therapy for those symptoms. Objectives • The investigation aimed to evaluate the effects of the supplement on sleep pattern (ie, sleep perception and objective sleep) and on menopausal symptoms. Design • The research team created a case report...
March 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28266947/to-the-editor
#18
Carolina Vicente Banzoli, Andréia Gomes Bezerra, Sergio Tufik, Helena Hachul
No abstract text is available yet for this article.
June 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28223243/on-the-verge-of-a-respiratory-type-panic-attack-selective-activations-of-rostrolateral-and-caudoventrolateral-periaqueductal-gray-matter-following-short-lasting-escape-to-a-low-dose-of-potassium-cyanide
#19
Cláudia Janaina Torres Müller, Jeyce Willig Quintino-Dos-Santos, Fagna Giacomin Schimitel, Sérgio Tufik, Vanessa Beijamini, Newton Sabino Canteras, Luiz Carlos Schenberg
Intravenous injections of potassium cyanide (KCN) both elicit escape by its own and facilitate escape to electrical stimulation of the periaqueductal gray matter (PAG). Moreover, whereas the KCN-evoked escape is potentiated by CO2, it is suppressed by both lesions of PAG and clinically effective treatments with panicolytics. These and other data suggest that the PAG harbors a hypoxia-sensitive alarm system the activation of which could both precipitate panic and render the subject hypersensitive to CO2. Although prior c-Fos immunohistochemistry studies reported widespread activations of PAG following KCN injections, the employment of repeated injections of high doses of KCN (>60µg) in anesthetized rats compromised both the localization of KCN-responsive areas and their correlation with escape behavior...
February 20, 2017: Neuroscience
https://www.readbyqxmd.com/read/28216961/menopausal-symptoms-and-obesity-is-there-a-relationship
#20
Maria Fernanda Naufel, Cristina Frange, Sérgio Tufik, Helena Hachul
No abstract text is available yet for this article.
October 2016: Journal of Pharmacy & Bioallied Sciences
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