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https://www.readbyqxmd.com/read/29783161/candidate-gene-analysis-in-the-s%C3%A3-o-paulo-epidemiologic-sleep-study-episono-shows-an-association-of-variant-in-pde4d-and-sleepiness
#1
Victoria M Pak, Diego R Mazzotti, Brendan T Keenan, Camila Hirotsu, Philip Gehrman, Lia Bittencourt, Allan I Pack, Sergio Tufik
INTRODUCTION: Sleepiness and cardiovascular disease share common molecular pathways; thus, genetic risk factors for sleepiness may also predict cardiovascular disease risk. This study explored the associations between subjective sleepiness and single-nucleotide polymorphisms (SNPs) in candidate genes within oxidative stress, inflammatory, and neuronal pathways, which may contribute to sleepiness and downstream cardiovascular disease risk: Cytochrome B-245, Alpha Polypeptide (CYBA), Cytochrome B-245, Beta Polypeptide (CYBB), Neutrophil Cytosolic Factor (NCF2), Tumor Necrosis Factor-Alpha (TNFA), and Phosphodiesterase 4D (PDE4D)...
January 12, 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29765923/insomnia-with-musculoskeletal-pain-in-postmenopause-associations-with-symptoms-mood-and-quality-of-life
#2
Cristina Frange, Helena Hachul, Camila Hirotsu, Sergio Tufik, Monica Levy Andersen
Objectives: To investigate the relationship between insomnia (INS) combined with chronic musculoskeletal pain (MSP) in postmenopausal women and its characteristics regarding MSP, menopausal and mood symptoms, sleep and quality of life (QOL). Methods: A cross-sectional control study in 4 groups of postmenopausal women: control (n = 15), MSP (n = 15), INS (n =15) and INS + MSP (n = 17). Sixty-two participants completed questionnaires and had blood collected, and 43 underwent polysomnography...
April 2018: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/29764215/myotonic-dystrophytype-1-report-of-non-24-h-sleep-wake-disorder-with-excessive-daytime-sleepiness
#3
Lucio Huebra Pimentel Filho, Ana Carolina Dias Gomes, Bruno Gonçalves, Sergio Tufik, Fernando Morgadinho Coelho
Myotonic dystrophy (MD) is a neuromuscular disease with myotonia, progressive weakness, and involvement of CNS, heart, and gastrointestinal system. Excessive daytime sleepiness (EDS) in myotonic dystrophy type 1 (MD1) is related to sleep breathing diseases, restless leg syndrome, periodic limb movements during sleep and narcoleptic-like phenotype. However, authors highlight a central dysfunction of sleep regulation. We describe a 26-year-old, female, MD1 patient with EDS. Sleep diary/actigraphy evidenced two different circadian periods with values of 1442 and 1522 min...
May 15, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29734993/the-effects-of-sildenafil-on-the-respiratory-system-of-patients-with-obstructive-sleep-apnea-and-erectile-dysfunction
#4
Monica L Andersen, Sergio Tufik
No abstract text is available yet for this article.
April 30, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29704826/premenstrual-syndrome-and-sleep-disturbances-results-from-the-sao-paulo-epidemiologic-sleep-study
#5
Zaira F M Nicolau, Andréia G Bezerra, Daniel N Polesel, Monica L Andersen, Lia Bittencourt, Sergio Tufik, Helena Hachul
The aim of this study is to compare sleep characteristics between women with premenstrual syndrome (PMS) and a control group. The data were extracted from an epidemiologic survey conducted in Sao Paulo (EPISONO), Brazil, which used subjective assessments and objective polysomnography records to analyze subjects' sleep pattern. Subjective questionnaires used in this study were Women's Questionnaire, Pittsburgh Sleep Quality Index, Epworth sleepiness scale, Insomnia Severity Index and the general sleep questionnaire...
April 3, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29702204/chronic-intermittent-hypoxia-induces-changes-on-the-expression-and-activity-of-neprilysin-ec-3-4-24-16-in-the-brain-of-rats
#6
Renato W de Oliveira, Guilherme S Julian, Juliana C Perry, Sergio Tufik, Jair R Chagas
Obstructive sleep apnea (OSA) is a frequent sleeping breathing disorder associated with cognitive impairments. Neprilysin (NEP) is responsible for degrading several substrates related to cognition; however, the effect of chronic intermittent hypoxia (CIH) on NEP is still unknown. This study aimed to evaluate the expression and activity of NEP under CIH in cognitive-related brain structures. Western blot, qRT-PCR and enzyme activity assay, demonstrated that a six-week intermittent hypoxia increased NEP expression and activity, selectively in temporal cortex, but not in the hippocampus and frontal cortex...
April 24, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29658807/effect-of-bright-light-therapy-on-delayed-sleep-wake-cycle-and-reaction-time-of-athletes-participating-in-the-rio-2016-olympic-games
#7
João Paulo P Rosa, Andressa Silva, Dayane F Rodrigues, Mário Antônio Simim, Fernanda V Narciso, Sergio Tufik, Jorge J Bichara, Sebastian Rafael D Pereira, Sidney C Da Silva, Marco Tulio de Mello
This study investigated the effect of using an artificial bright light on the entrainment of the sleep/wake cycle as well as the reaction times of athletes before the Rio 2016 Olympic Games. A total of 22 athletes from the Brazilian Olympic Swimming Team were evaluated, with the aim of preparing them to compete at a time when they would normally be about to go to bed for the night. During the 8-day acclimatization period, their sleep/wake cycles were assessed by actigraphy, with all the athletes being treated with artificial light therapy for between 30 and 45 min (starting at day 3)...
April 16, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29649791/the-long-term-impact-of-high-levels-of-alpha-melanocyte-stimulating-hormone-in-energy-balance-among-obese-adolescents
#8
Ana Claudia Pelissari Kravchychyn, Raquel Munhoz da Silveira Campos, Flávia Campos Corgosinho, Deborah Cristina Landi Masquio, Sofia Emanuelle de Castro Ferreira Vicente, Yasmin Alaby Martins Ferreira, Patrícia Leão Silva, Aline de Piano Ganen, Lila Missae Oyama, Lian Tock, Marco Túlio de Mello, Sérgio Tufik, Ana Raimunda Dâmaso
BACKGROUND: Deregulation of orexigenic and anorexigenic pathways occurs among adolescents with obesity. Alpha-melanocyte-stimulating hormone (α-MSH) is a key catabolic mediator of energy homeostasis and an important anorexigenic neuropeptide in the control of energy balance and thermogenesis. However, it was not well explored if α-MSH can modulate long-term weight loss therapy responses in a dependent manner according to its concentration. Our hypothesis is that a high α-MSH concentration at baseline promotes better modulation of anorexigenic/orexigenic pathways in obese adolescents...
April 12, 2018: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29565956/neonatal-sleep-restriction-increases-nociceptive-sensitivity-in-adolescent-mice
#9
Paula Araujo, Cesar A Coelho, Maria G Oliveira, Sergio Tufik, Monica L Andersen
BACKGROUND: Sleep loss in infants may have a negative effect on the functional and structural development of the nociceptive system. We tested the hypothesis that neonatal sleep restriction induces a long-term increase of pain-related behaviors in mice and that this hypersensitivity occurs due to changes in the neuronal activity of nociceptive pathways. OBJECTIVES: We aim to investigate the effects of sleep loss in neonatal mice on pain behaviors of adolescent and adult mice in a sex-dependent manner...
March 2018: Pain Physician
https://www.readbyqxmd.com/read/29508656/is-there-a-relationship-between-excessive-sugar-consumption-and-sleep-quality-in-children
#10
Nadia Raci Marques Pereira, Sergio Tufik, Helena Hachul
No abstract text is available yet for this article.
March 6, 2018: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/29421538/sleep-deprivation-precipitates-the-development-of-amphetamine-induced-conditioned-place-preference-in-rats
#11
Laís F Berro, Sergio B Tufik, Roberto Frussa-Filho, Monica L Andersen, Sergio Tufik
Sleep deprivation (SD) and amphetamine use are commonly associated conditions. SD shares similar neurobiological effects with psychostimulants, playing an important role in drug addiction, especially through conditioning manipulations. The aim of the present study was to investigate the effects of SD on the development of amphetamine-induced conditioned place preference (CPP) in a protocol with a reduced number of conditioning sessions. Male adult Wistar rats were submitted to 4 conditioning sessions (2 sessions/day) in the CPP apparatus, half with saline (non-drug-paired compartment) and half with 2 mg/kg amphetamine (drug-paired compartment) after control (home-cage maintained) or SD (6 h gentle handling method) conditions...
April 3, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29415833/short-term-l-arginine-supplementation-attenuates-elevation-of-interleukin-6-level-after-resistance-exercise-in-overweight-men
#12
Marcos Antonio do Nascimento, Fábio Dos Santos Lira, Giovana Rita Punaro, Marco Túlio de Mello, Sérgio Tufik, Elisa Mieko Suemitsu Higa
BACKGROUND AND AIM: l-Arginine (l-arg) supplementation and resistance exercise can induce changes in inflammatory and anti-inflammatory cytokines; however, it has not been investigated in obese hypertensive men. This study examines the effects of short-term l-arg supplementation and acute resistance exercise (AREX) on cytokine levels in obese hypertensive men. METHODS: Eight obese hypertensive men aged 46 ± 6 yrs. with an average body weight of 92.56 ± 9...
December 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29410751/michel-jouvet-and-his-importance-for-brazilian-preclinical-sleep-research
#13
Gabriel Natan Pires, Sergio Tufik, Monica Andersen
No abstract text is available yet for this article.
October 2017: Sleep Science
https://www.readbyqxmd.com/read/29410750/women-s-sleep-disorders-integrative-care
#14
Cristina Frange, Carolina Vicente Banzoli, Ana Elisa Colombo, Marcele Siegler, Glaury Coelho, Andréia Gomes Bezerra, Marcelo Csermak, Maria Fernanda Naufel, Cristiana Cesar-Netto, Monica Levy Andersen, Manoel João Batista Castelo Girão, Sergio Tufik, Helena Hachul
The integrative care model is rooted in a biopsychosocial approach. Integrative is a term which refers to increasing the harmony and coherence of your whole being, and integrative care is therefore focused on the person, not on either the disease or a therapy. It is provided collaboratively by a health team comprising physicians, psychologists, physiotherapists, acupuncturists, and meditation, nutrition, and floral therapy. Previous studies have demonstrated that interventions based on the integrative care model improved womens lifestyle and quality of life...
October 2017: Sleep Science
https://www.readbyqxmd.com/read/29351822/influence-of-obstructive-sleep-apnea-in-the-functional-aspects-of-patients-with-osteoarthritis
#15
Andressa Silva, Marco Túlio Mello, Paula Regina Serrão, Roberta Pitta Luz, Franciele Ruiz, Lia Rita Bittencourt, Sergio Tufik, Stela Márcia Mattiello
STUDY OBJECTIVES: It has been demonstrated in recent studies that obstructive sleep apnea (OSA) is the most prevalent sleep disorder in patients with osteoarthritis (OA), and thus the current study aimed to investigate the influence of OSA on knee extensor torque, pain, stiffness, and physical function in men with low-grade knee OA. METHODS: The study included 60 male volunteers, aged 40 to 70 years, allocated into four groups: Group 1 (G1) Control (n = 15): without OA and without OSA; Group 2 (G2) (n = 15): with OA and without OSA; Group 3 (G3) (n = 15): without OA and with OSA; and Group 4 (G4) (n = 15) with OA and with OSA...
February 15, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29315434/recognizable-clinical-subtypes-of-obstructive-sleep-apnea-across-international-sleep-centers-a-cluster-analysis
#16
Brendan T Keenan, Jinyoung Kim, Bhajan Singh, Lia Bittencourt, Ning-Hung Chen, Peter A Cistulli, Ulysses J Magalang, Nigel McArdle, Jesse W Mindel, Bryndis Benediktsdottir, Erna Sif Arnardottir, Lisa Kristin Prochnow, Thomas Penzel, Bernd Sanner, Richard J Schwab, Chol Shin, Kate Sutherland, Sergio Tufik, Greg Maislin, Thorarinn Gislason, Allan I Pack
Study Objectives: A recent study of patients with moderate-severe obstructive sleep apnea (OSA) in Iceland identified three clinical clusters based on symptoms and comorbidities. We sought to verify this finding in a new cohort in Iceland and examine the generalizability of OSA clusters in an international ethnically diverse cohort. Methods: Using data on 972 patients with moderate-severe OSA (apnea-hypopnea index [AHI] ≥ 15 events per hour) recruited from the Sleep Apnea Global Interdisciplinary Consortium (SAGIC), we performed a latent class analysis of 18 self-reported symptom variables, hypertension, cardiovascular disease, and diabetes...
March 1, 2018: Sleep
https://www.readbyqxmd.com/read/29164263/plasma-leptin-and-premenstrual-syndrome-a-review
#17
Zaira Fernanda Martinho Nicolau, Andréia Gomes Bezerra, Daniel Ninello Polesel, Monica Levy Andersen, Sergio Tufik, Helena Hachul
Importance: Premenstrual syndrome (PMS) is characterized by physical and psychological symptoms in the luteal phase. Leptin can influence PMS as it acts on the hypothalamic-pituitary-gonadal axis. Objective: The aim of this study was to evaluate data in the literature about the profile of plasma leptin in women with PMS. Evidence Acquisition: We performed a search of databases using both descriptors. Three studies were identified. They included 181 participants...
November 2017: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/29148894/metabolic-profile-in-patients-with-mild-obstructive-sleep-apnea
#18
Luciana Oliveira E Silva, Thais M Guimarães, Gabriela P Luz, Glaury Coelho, Luciana Badke, Ildonete R Almeida, Aline Millani-Carneiro, Sergio Tufik, Lia Bittencourt, Sonia M Togeiro
BACKGROUND: Mild obstructive sleep apnea (OSA) is a highly prevalent disorder in adults. However, it is not clear whether mild OSA has significant metabolic complications. This study examined the prevalence of metabolic syndrome (MS) in patients with mild OSA compared to control group. METHODS: Adults (18-65 years of age) of both genders with a body mass index (BMI) ≤35 kg/m2 were included. The mild OSA group comprised of patients with an apnea-hypopnea index (AHI) score of ≥5 but ≤15 events/hr of sleep, independent of other symptoms...
February 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29098525/prognostic-value-of-real-time-three-dimensional-echocardiography-compared-to-two-dimensional-echocardiography-in-patients-with-systolic-heart-failure
#19
Frederico J N Mancuso, Valdir A Moises, Dirceu R Almeida, Dalva Poyares, Luciana J Storti, Flavio S Brito, Sergio Tufik, Angelo A V de Paola, Antonio C C Carvalho, Orlando Campos
Heart failure (HF) is associated with morbidity and mortality. Real-time three-dimensional echocardiography (RT3DE) may offer additional prognostic data in patients with HF. The study aimed to evaluate the prognostic value of real-time three-dimensional echocardiography (RT3DE). This is a prospective study that included 89 patients with HF and left ventricular ejection fraction (LVEF) < 0.50 who were followed for 48 months. Left atrium and ventricular volumes and functions were evaluated by RT3DE. TDI and two-dimensional echocardiography parameters were also obtained...
November 2, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29045745/long-term-oral-appliance-therapy-improves-daytime-function-and-mood-in-upper-airway-resistance-syndrome-patients
#20
Luciana B M Godoy, Luciana Palombini, Dalva Poyares, Cibele Dal-Fabbro, Thaís Moura Guimarães, Priscila Calixto Klichouvicz, Sergio Tufik, Sonia Maria Togeiro
Objectives: To evaluate the long-term effects of an oral appliance on clinical symptoms, respiratory sleep parameters, sleep quality, and sustained attention in patients with upper airway resistance syndrome (UARS) were compared with placebo. Methods: This study was a randomized placebo-controlled clinical trial. Thirty UARS patients were randomized in two groups: placebo and mandibular advancement device (MAD) groups. UARS criteria were presence of sleepiness (Epworth Sleepiness Scale ≥ 10) and/or fatigue (Modified Fatigue Impact Scale ≥ 38) associated with an apnea/hypopnea index ≤ 5 and a respiratory disturbance index (RDI) > 5 events/hour of sleep, and/or flow limitation in more than 30% of total sleep time...
December 1, 2017: Sleep
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