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Sergio tufik

Priscila Farias Tempaku, Diego Robles Mazzotti, Camila Hirotsu, Monica Levy Andersen, Gabriela Xavier, Pawan Kumar Maurya, Lucas Bortolotto Rizzo, Elisa Brietzke, Sintia Iole Belangero, Lia Bittencourt, Sergio Tufik
Aging is associated with an increase in the prevalence of obstructive sleep apnea syndrome (OSAS) as well as the shortening of telomeres. It is known that OSAS-related factors are stimuli that can contribute to the acceleration of cellular senescence. Thus, the present study aimed to compare the leukocyte telomere length (LTL) between OSAS patients and controls, as well as to verify the correlation between LTL and sleep parameters. We used DNA extracted of 928 individuals from EPISONO to measure the LTL by the quantitative real-time polymerase chain reaction...
September 27, 2016: Oncotarget
Radamés Maciel Vítor Medeiros, Eduardo da Silva Alves, Valdir de Aquino Lemos, Paulo Adriano Schwingel, Andressa da Silva, Roberto Vital, Alexandre Silva Vieira, Murilo Moreira Barreto, Edilson Alves da Rocha, Sergio Tufik, Marco Túlio de Mello
CONTEXT: Body composition assessments of high-performance athletes are very important for identifying physical performance potential. Although the relationship between the kinanthropometric characteristics and performance abilities of Olympic swimmers is extremely important, this subject is not completely understood for Paralympic swimmers. OBJECTIVE: To investigate the relationship between body composition and sport performance in Brazilian Paralympic swimmers 6 months after training...
August 24, 2016: Journal of Sport Rehabilitation
Francieli Barreiro-Ribeiro, Ana Carolina Junqueira Vasques, Cleliani de Cassia da Silva, Mariana Porto Zambon, Ana Maria De Bernardi Rodrigues, Daniella Fernandes Camilo, Maria Ângela Reis de Góes Monteiro Antonio, Ana Raimunda Dâmaso, Raquel Munhoz da Silveira Campos, Sergio Tufik, Marco Túlio de Mello, Bruno Geloneze
OBJECTIVE: This study aimed to identify cutoff points for detecting hypertriglyceridemic waist phenotype (HTWP) in adolescents and to investigate the association of the HTWP with insulin resistance (IR) and metabolic syndrome components. METHODS: A multicentric cross-sectional study of 861 adolescents (10-19 years of age, 504 girls) was conducted. Pubertal stage, anthropometric, and laboratory parameters were assessed. IR was assessed by Homeostasis Model Assessment for Insulin Resistance (HOMA1-IR) index and hyperglycemic clamp (n = 80)...
September 14, 2016: Childhood Obesity
Camila Hirotsu, Rachel G Albuquerque, Heloisa Nogueira, Helena Hachul, Lia Bittencourt, Sergio Tufik, Monica L Andersen
Obstructive sleep apnea (OSA) has been associated with increased risk of cardiovascular morbidity and mortality. Although inflammatory markers may mediate this association, it is unknown the influence of gender in this mechanism. Thus, we aimed to evaluate the interaction effects between OSA and gender on metabolic and inflammatory profile in a population sample. This study is part of EPISONO cohort, in which 1042 participants underwent polysomnography, answered questionnaires, and had their blood collected for analysis of fasting glucose, total cholesterol and fractions, leptin, ghrelin, liver transaminases, tumor necrosis factor (TNF)-α, interleukin (IL)-6, and C-reactive protein...
September 9, 2016: Brain, Behavior, and Immunity
Erika Treptow, Mayron F Oliveira, Aline Soares, Roberta P Ramos, Luiz Medina, Rita Lima, Maria Clara Alencar, Eloara Vieira Ferreira, Jaquelina S Ota-Arakaki, Sergio Tufik, Luiz E Nery, Lia Rita Bittencourt, J Alberto Neder
Hypocapnia and endothelial dysfunction might impair microvascular cerebral blood flow (CBFmicr) and cerebrovascular reactivity to CO2 (CVRCO2). Pulmonary arterial hypertension (PAH) is characteristically associated with chronic alveolar hyperventilation and microvascular endothelial dysfunction. We therefore determined CBFmicr (pre-frontal blood flow index (BFI) by the indocyanine green-near infrared spectroscopy methodology) during hypocapnia and hypercapnia in 25 PAH patients and 10 gender- and age-matched controls...
November 2016: Respiratory Physiology & Neurobiology
Mariana Santos-Camilo, Stefanie Pires Arães, Camila Hirotsu, Sergio Tufik, Monica Levy Andersen
No abstract text is available yet for this article.
2016: Therapeutics and Clinical Risk Management
Valdir De Aquino Lemos, Eduardo Da Silva Alves, Paulo Adriano Schwingel, João Paulo Pereira Rosa, Andressa Da Silva, Ciro Winckler, Roberto Vital, Alexandre Aparecido De Almeida, Sergio Tufik, Marco Túlio De Mello
Body composition is a physiological variable associated with physical activity and, in some cases, is related to athletic performance. Our objectives were to describe the body composition of participants in three distinct Paralympic sports and to compare the values of body density and estimated body fat obtained from the Paralympic athletes on the National Team by air-displacement plethysmography (ADP) and by the anthropometric method (skinfolds (SFs)). The sample consisted of 70 volunteers of both genders...
November 2016: European Journal of Sport Science
Silvio Araújo Fernandes-Junior, Francieli Silva Ruiz, Leandro Stetner Antonietti, Sergio Tufik, Marco Túlio de Mello
INTRODUCTION: The reversal of the natural cycle of wakefulness and sleep may cause damage to the health of workers. However, there are few studies evaluating sleep, fatigue and quality of life of night shift workers considering the influence of small children on these variables. AIMS: Evaluate the sleep time, fatigue and quality of life of night shift workers and verify the relationship between these variables with the presence or absence of children in different age groups...
2016: PloS One
Raquel M Campos, Deborah C Masquio, Flavia C Corgosinho, Priscila DE Lima Sanches, Aline DE Piano, June Carnier, Patricia L DA Silva, Ana P Clemente, Sofia E Vicente, Lila M Oyama, Claudia M DO Nascimento, Lian Tock, Sergio Tufik, Marco T DE Mello, Ana R Damaso
BACKGROUND: Homeostasis Model Assessment-Adiponectin (HOMA-AD) is suggesting a new biomarker of insulin resistance in obese population. In this way, the purpose of this study was to investigate the effects of different kinds of exercise in the sensitive index predictor of insulin resistance. METHODS: A total of 148 obese adolescents were enrolled in the program. They aged 15- 19y, with body mass index (BMI) ≥ P95th and were submitted to 1 year of interdisciplinary weight loss therapy, randomized in two groups, aerobic training (n=51) and aerobic plus resistance training (n=97)...
July 6, 2016: Journal of Sports Medicine and Physical Fitness
Guilherme Silva Julian, Renato Watanabe de Oliveira, Sergio Tufik, Jair Ribeiro Chagas
Obstructive sleep apnea (OSA) has been associated with oxidative stress and various cardiovascular consequences, such as increased cardiovascular disease risk. Quantitative real-time PCR is frequently employed to assess changes in gene expression in experimental models. In this study, we analyzed the effects of chronic intermittent hypoxia (an experimental model of OSA) on housekeeping gene expression in the left cardiac ventricle of rats. Analyses via four different approaches-use of the geNorm, BestKeeper, and NormFinder algorithms; and 2-ΔCt (threshold cycle) data analysis-produced similar results: all genes were found to be suitable for use, glyceraldehyde-3-phosphate dehydrogenase and 18S being classified as the most and the least stable, respectively...
May 2016: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
Gabriel Natan Pires, Andréia Gomes Bezerra, Sergio Tufik, Monica Levy Andersen
Increased acute anxiety is a commonly reported behavioral consequence of sleep deprivation in humans. However, rodent studies conducted so far produced inconsistent results, failing to reproduce the same sleep deprivation induced-anxiety observed in clinical experiments. While some presented anxiogenesis as result of sleep deprivation, others reported anxiolysis. In face of such inconsistencies, this article explores the effects of experimental sleep deprivation on anxiety-like behavior in animal research through a systematic review and a series of meta-analyses...
September 2016: Neuroscience and Biobehavioral Reviews
Helena Marti-Soler, Camila Hirotsu, Pedro Marques-Vidal, Peter Vollenweider, Gérard Waeber, Martin Preisig, Mehdi Tafti, Sergio Brasil Tufik, Lia Bittencourt, Sergio Tufik, José Haba-Rubio, Raphael Heinzer
BACKGROUND: Diagnosis of sleep-disordered breathing requires overnight recordings, such as polygraphy or polysomnography. Considering the cost and low availability of these procedures, preselection of patients at high risk is recommended. We aimed to develop a screening tool allowing identification of individuals at risk of sleep-disordered breathing. METHODS: We used the participants from the population-based HypnoLaus cohort in Lausanne, Switzerland, who had a clinical assessment and polysomnography at home, to build a clinical score (the NoSAS score) using multiple factor analysis and logistic regression to identify people likely to have clinically significant sleep-disordered breathing...
September 2016: Lancet Respiratory Medicine
Luciana Balester Mello de Godoy, Gabriela Pontes Luz, Luciana Oliveira Palombini, Luciana Oliveira E Silva, Wilson Hoshino, Thaís Moura Guimarães, Sergio Tufik, Lia Bittencourt, Sonia Maria Togeiro
PURPOSE: To compare sleep quality and sustained attention of patients with Upper Airway Resistance Syndrome (UARS), mild Obstructive Sleep Apnea (OSA) and normal individuals. METHODS: UARS criteria were presence of excessive daytime sleepiness (Epworth Sleepiness Scale-ESS-≥ 10) and/or fatigue (Modified Fatigue Impact Scale-MFIS-≥ 38) associated to Apnea/hypopnea index (AHI) ≤ 5 and Respiratory Disturbance Index (RDI) > 5 events/hour of sleep or more than 30% of total sleep time with flow limitation...
2016: PloS One
Adriana T Ramos, Sergio Tufik, Lanfranco R P Troncone
Vasopressin and CRH have complementary roles in the secretion of ACTH following different stress modalities. The concomitant use of V1b and CRF1 receptor antagonists completely inhibits ACTH secretion in response to different stress modalities. The combination of the CRF1 antagonist SSR125543 with the V1b antagonist SSR149415 effectively suppressed plasma ACTH 1.30 h after injection in rats stressed by ether vapor inhalation for 1 min, restraint stress for 1 h or forced swimming for 5 min. The duration of the effect was also studied...
2016: Neuropsychobiology
Mayra Dos Santos Silva, Caroline Moreira Bazzana, Altay Lino de Souza, Luiz Roberto Ramos, Sergio Tufik, Lígia M Lucchesi, Guiomar Silva Lopes
[This corrects the article DOI: 10.1016/j.slsci.2015.04.002.].
January 2016: Sleep Science
Danilo Anunciatto Sguillar, Tatiana de Aguiar Vidigal, João Paulo Mangussi, Lia Bittencourt, Luiz Carlos Gregório, Sergio Tufik, Fernanda Louise Martinho Haddad
PURPOSE: The goal of this study was to investigate the agreement between examiners who were or were not trained in the physical examination of the upper airway (UA) and the craniofacial skeleton of individuals with obstructive sleep disorders (OSD). METHOD: A systematic assessment of the UA and craniofacial skeleton was performed on 55 individuals with OSD. The participants were consecutively assessed by three otorhinolaryngologists who specialized in sleep medicine for at least 1 year (trained examiners) and two doctors who were attending a residency program in otorhinolaryngology (untrained examiners)...
May 23, 2016: Sleep & Breathing, Schlaf & Atmung
Lenise Jihe Kim, Fernando Morgadinho Coelho, Paula Araujo, Roberto Carlos Tedesco, Rodrigo Barbosa Souza, Sergio Tufik, Monica Levy Andersen
Cerebral blood flow is associated with the cerebrovascular prognosis. Sleep restriction (SR) may be a limiting factor of the prognosis after a cerebrovascular event, impairing the neurological recovery. We aimed to investigate the effects of SR on mortality rate and on behavioral and histological parameters of animals submitted to permanent cerebral hypoperfusion. Sixty male Wistar rats were distributed in 4 groups, according to the protocol of common carotid artery occlusion (CCAO) and SR: nSR+nCCAO, SR+nCCAO, nSR+CCAO, and SR+CCAO...
August 1, 2016: Brain Research
Rodrigo C Gatti, Patrick R Burke, Leonardo J Otuyama, Dirceu R Almeida, Sergio Tufik, Dalva Poyares
STUDY OBJECTIVE: This study aimed to evaluate the effects of zolpidem CR (controlled release) on sleep and nocturnal ventilation in patients with congestive heart failure, a population at risk for insomnia and poor sleep quality. METHODS: Fifteen patients with heart failure (ischemic cardiomyopathy) and ejection fraction ≤ 45% in NYHA functional class I or II were evaluated with full polysomnography in a placebo-controlled, double-blind, randomized trial. Patients underwent three tests: (1) baseline polysomnography and, after randomization, (2) a new test with zolpidem CR 12...
2016: Sleep
Deborah Cristina Landi Masquio, Aline de Piano-Ganen, Lila Missae Oyama, Raquel Munhoz da Silveira Campos, Aline Boveto Santamarina, Gabriel Inácio de Morais Honorato de Souza, Aline Dal'Olio Gomes, Renata Guimarães Moreira, Flávia Campos Corgosinho, Claudia Maria Oller do Nascimento, Lian Tock, Sergio Tufik, Marco Túlio de Mello, Ana R Dâmaso
The purpose of the present study was to evaluate if interdisciplinary therapy can influence the cardiometabolic and serum free fatty acid profile. The second aim was to evaluate if there is an association between serum free fatty acids, inflammation and cardiometabolic biomarkers in obese adolescents with and without metabolic syndrome submitted to a long-term interdisciplinary therapy. The study involved 108 postpuberty obese adolescents, who were divided according to metabolic syndrome (MetS) diagnosis: MetS (n=32) and Non-MetS (n=76)...
July 2016: Journal of Nutritional Biochemistry
Fernanda Veruska Narciso, José A Barela, Stefane A Aguiar, Adriana N S Carvalho, Sergio Tufik, Marco Túlio de Mello
The purpose of the study was to investigate the effects of shift work on the psychomotor and postural performance of night workers. The study included 20 polysomnography technicians working schedule of 12-h night shift by 36-h off. On the first day of protocol, the body mass and height were measured, and an actigraph was placed on the wrist of each participant. On the second day of protocol, sleepiness by Karolinska Sleepiness Scale, postural control by force platform (30 seconds) and psychomotor performance by Psychomotor Vigilance Task (10 minutes) were measured before and after 12-h night work...
2016: PloS One
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