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https://www.readbyqxmd.com/read/27913971/myofunctional-therapy-improves-adherence-to-continuous-positive-airway-pressure-treatment
#1
Giovana Diaféria, Rogerio Santos-Silva, Eveli Truksinas, Fernanda L M Haddad, Renata Santos, Silvana Bommarito, Luiz C Gregório, Sergio Tufik, Lia Bittencourt
PURPOSE: Few studies have investigated myofunctional therapy in patients with obstructive sleep apnea syndrome (OSAS). The objective of this study was to evaluate the effect of myofunctional therapy on continuous positive airway pressure (CPAP) adherence. METHODS: The study was registered at ClinicalTrials.gov (NCT01289405). Male patients with OSAS were randomly divided into four treatment groups: placebo, patients undergoing placebo myofunctional therapy (N = 24); myofunctional therapy, undergoing myofunctional therapy (N = 27); CPAP, undergoing treatment with CPAP (N = 27); and combined, undergoing CPAP therapy and myofunctional therapy (N = 22)...
December 2, 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/27901185/applicability-of-predictive-equations-for-resting-energy-expenditure-in-obese-patients-with-obstructive-sleep-apnea
#2
Mariana Pantaleão Del Re, Camila Maria de Melo, Marcus Vinicius Dos Santos, Sergio Tufik, Marco Túlio de Mello
Objective: To investigate the applicability of predictive equations for resting energy expenditure (REE) in obese individuals with obstructive sleep apnea (OSA) and the effects of OSA severity on REE. Materials and methods: Twenty-nine obese men, 41.5 ± 7 years old, with moderate and severe OSA were recruited. All subjects were submitted to a clinical polysomnography, body composition, and indirect calorimetry measurements. REE was also predicted by three different equations: Harris and Benedict (1919), Cunningham (1990), and DRI (2002)...
November 24, 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27880816/paradoxical-sleep-deprivation-causes-cardiac-dysfunction-and-the-impairment-is-attenuated-by-resistance-training
#3
Sara Quaglia de Campos Giampá, Marcos Mônico-Neto, Marco Tulio de Mello, Helton de Sá Souza, Sergio Tufik, Kil Sun Lee, Marcia Kiyomi Koike, Alexandra Alberta Dos Santos, Ednei Luiz Antonio, Andrey Jorge Serra, Paulo José Ferreira Tucci, Hanna Karen Moreira Antunes
BACKGROUND: Paradoxical sleep deprivation activates the sympathetic nervous system and the hypothalamus-pituitary-adrenal axis, subsequently interfering with the cardiovascular system. The beneficial effects of resistance training are related to hemodynamic, metabolic and hormonal homeostasis. We hypothesized that resistance training can prevent the cardiac remodeling and dysfunction caused by paradoxical sleep deprivation. METHODS: Male Wistar rats were distributed into four groups: control (C), resistance training (RT), paradoxical sleep deprivation for 96 hours (PSD96) and both resistance training and sleep deprivation (RT/PSD96)...
2016: PloS One
https://www.readbyqxmd.com/read/27827949/carbohydrate-supplementation-influences-serum-cytokines-after-exercise-under-hypoxic-conditions
#4
Aline Venticinque Caris, Edgar Tavares Da Silva, Samile Amorim Dos Santos, Fabio Santos Lira, Lila Missae Oyama, Sergio Tufik, Ronaldo Vagner Thomatieli Dos Santos
INTRODUCTION: Exercise performed at the hypoxia equivalent of an altitude of 4200 m is associated with elevated inflammatory mediators and changes in the Th1/Th2 response. By contrast, supplementation with carbohydrates has an anti-inflammatory effect when exercise is performed under normoxic conditions. The objective of this study was to evaluate the effect of carbohydrate supplementation on cytokines and cellular damage markers after exercise under hypoxic conditions at a simulated altitude of 4200 m...
November 5, 2016: Nutrients
https://www.readbyqxmd.com/read/27810176/effects-of-acute-sleep-deprivation-on-state-anxiety-levels-a-systematic-review-and-meta-analysis
#5
REVIEW
Gabriel Natan Pires, Andreia Gomes Bezerra, Sergio Tufik, Monica Levy Andersen
Increased anxiety levels have been widely recognized as one of the most important consequences of sleep deprivation. However, despite this general consensus, there are still aspects of this relationship, such as the extent of the anxiogenic potential and the specific effects of different types of sleep deprivation, which remain unclear. As no broad review has been undertaken to evaluate this relationship, we performed a systematic review and meta-analysis regarding the effects of sleep deprivation on state anxiety...
August 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27796270/sleep-restriction-during-pregnancy-and-its-effects-on-blood-pressure-and-renal-function-among-female-offspring
#6
Rogério Argeri, Erika E Nishi, Rildo A Volpini, Beatriz D Palma, Sergio Tufik, Guiomar N Gomes
The influence of sleep restriction (SR) during pregnancy on blood pressure and renal function among female adult offspring was investigated. Pregnant Wistar rats were distributed into control and SR groups. The SR was performed between the 14th and 20th days of pregnancy (multiple platforms method for 20 h/day). At 2 months of age, half of the offspring from both groups were subjected to an ovariectomy (ovx), and the other half underwent sham surgery. The groups were as follows: control sham (Csham), control ovx (Covx), SR sham (SRsham), and SR ovx (SRovx)...
August 2016: Physiological Reports
https://www.readbyqxmd.com/read/27690344/the-effect-of-the-severity-of-obstructive-sleep-apnea-syndrome-on-telomere-length
#7
Priscila Farias Tempaku, Diego Robles Mazzotti, Camila Hirotsu, Monica Levy Andersen, Gabriela Xavier, Pawan Kumar Maurya, Lucas Bortolotto Rizzo, Elisa Brietzke, Sintia Iole Belangero, Lia Bittencourt, Sergio Tufik
Aging is associated with an increase in the prevalence of obstructive sleep apnea syndrome (OSAS) as well as the shortening of telomeres. It is known that OSAS-related factors are stimuli that can contribute to the acceleration of cellular senescence. Thus, the present study aimed to compare the leukocyte telomere length (LTL) between OSAS patients and controls, as well as to verify the correlation between LTL and sleep parameters. We used DNA extracted of 928 individuals from EPISONO to measure the LTL by the quantitative real-time polymerase chain reaction...
September 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/27632832/assessment-of-body-composition-and-sport-performance-of-brazilian-paralympic-swimming-team-athletes
#8
Radamés Maciel Vítor Medeiros, Eduardo da Silva Alves, Valdir de Aquino Lemos, Paulo Adriano Schwingel, Andressa da Silva, Roberto Vital, Alexandre Silva Vieira, Murilo Moreira Barreto, Edilson Alves da Rocha, Sergio Tufik, Marco Túlio de Mello
CONTEXT: Body composition assessments of high-performance athletes are very important for identifying physical performance potential. Although the relationship between the kinanthropometric characteristics and performance abilities of Olympic swimmers is extremely important, this subject is not completely understood for Paralympic swimmers. OBJECTIVE: To investigate the relationship between body composition and sport performance in Brazilian Paralympic swimmers 6 months after training...
August 24, 2016: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/27627113/hypertriglyceridemic-waist-phenotype-indicates-insulin-resistance-in-adolescents-according-to-the-clamp-technique-in-the-brams-study
#9
Francieli Barreiro-Ribeiro, Ana Carolina Junqueira Vasques, Cleliani de Cassia da Silva, Mariana Porto Zambon, Ana Maria De Bernardi Rodrigues, Daniella Fernandes Camilo, Maria Ângela Reis de Góes Monteiro Antonio, Ana Raimunda Dâmaso, Raquel Munhoz da Silveira Campos, Sergio Tufik, Marco Túlio de Mello, Bruno Geloneze
OBJECTIVE: This study aimed to identify cutoff points for detecting hypertriglyceridemic waist phenotype (HTWP) in adolescents and to investigate the association of the HTWP with insulin resistance (IR) and metabolic syndrome components. METHODS: A multicentric cross-sectional study of 861 adolescents (10-19 years of age, 504 girls) was conducted. Pubertal stage, anthropometric, and laboratory parameters were assessed. IR was assessed by Homeostasis Model Assessment for Insulin Resistance (HOMA1-IR) index and hyperglycemic clamp (n = 80)...
September 14, 2016: Childhood Obesity
https://www.readbyqxmd.com/read/27621224/the-relationship-between-sleep-apnea-metabolic-dysfunction-and-inflammation-the-gender-influence
#10
Camila Hirotsu, Rachel G Albuquerque, Heloisa Nogueira, Helena Hachul, Lia Bittencourt, Sergio Tufik, Monica L Andersen
Obstructive sleep apnea (OSA) has been associated with increased risk of cardiovascular morbidity and mortality. Although inflammatory markers may mediate this association, it is unknown the influence of gender in this mechanism. Thus, we aimed to evaluate the interaction effects between OSA and gender on metabolic and inflammatory profile in a population sample. This study is part of EPISONO cohort, in which 1042 participants underwent polysomnography, answered questionnaires, and had their blood collected for analysis of fasting glucose, total cholesterol and fractions, leptin, ghrelin, liver transaminases, tumor necrosis factor (TNF)-α, interleukin (IL)-6, and C-reactive protein...
September 9, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27521776/cerebral-microvascular-blood-flow-and-co2-reactivity-in-pulmonary-arterial-hypertension
#11
Erika Treptow, Mayron F Oliveira, Aline Soares, Roberta P Ramos, Luiz Medina, Rita Lima, Maria Clara Alencar, Eloara Vieira Ferreira, Jaquelina S Ota-Arakaki, Sergio Tufik, Luiz E Nery, Lia Rita Bittencourt, J Alberto Neder
Hypocapnia and endothelial dysfunction might impair microvascular cerebral blood flow (CBFmicr) and cerebrovascular reactivity to CO2 (CVRCO2). Pulmonary arterial hypertension (PAH) is characteristically associated with chronic alveolar hyperventilation and microvascular endothelial dysfunction. We therefore determined CBFmicr (pre-frontal blood flow index (BFI) by the indocyanine green-near infrared spectroscopy methodology) during hypocapnia and hypercapnia in 25 PAH patients and 10 gender- and age-matched controls...
November 2016: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/27468237/correlation-between-obesity-and-chronic-kidney-disease-is-obstructive-sleep-apnea-an-interfering-factor
#12
Mariana Santos-Camilo, Stefanie Pires Arães, Camila Hirotsu, Sergio Tufik, Monica Levy Andersen
No abstract text is available yet for this article.
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27412133/analysis-of-the-body-composition-of-paralympic-athletes-comparison-of-two-methods
#13
Valdir De Aquino Lemos, Eduardo Da Silva Alves, Paulo Adriano Schwingel, João Paulo Pereira Rosa, Andressa Da Silva, Ciro Winckler, Roberto Vital, Alexandre Aparecido De Almeida, Sergio Tufik, Marco Túlio De Mello
Body composition is a physiological variable associated with physical activity and, in some cases, is related to athletic performance. Our objectives were to describe the body composition of participants in three distinct Paralympic sports and to compare the values of body density and estimated body fat obtained from the Paralympic athletes on the National Team by air-displacement plethysmography (ADP) and by the anthropometric method (skinfolds (SFs)). The sample consisted of 70 volunteers of both genders...
November 2016: European Journal of Sport Science
https://www.readbyqxmd.com/read/27391478/sleep-fatigue-and-quality-of-life-a-comparative-analysis-among-night-shift-workers-with-and-without-children
#14
Silvio Araújo Fernandes-Junior, Francieli Silva Ruiz, Leandro Stetner Antonietti, Sergio Tufik, Marco Túlio de Mello
INTRODUCTION: The reversal of the natural cycle of wakefulness and sleep may cause damage to the health of workers. However, there are few studies evaluating sleep, fatigue and quality of life of night shift workers considering the influence of small children on these variables. AIMS: Evaluate the sleep time, fatigue and quality of life of night shift workers and verify the relationship between these variables with the presence or absence of children in different age groups...
2016: PloS One
https://www.readbyqxmd.com/read/27385541/homa-ad-the-role-of-different-types-of-physical-exercise-in-obese-adolescents
#15
Raquel M Campos, Deborah C Masquio, Flavia C Corgosinho, Priscila DE Lima Sanches, Aline DE Piano, June Carnier, Patricia L DA Silva, Ana P Clemente, Sofia E Vicente, Lila M Oyama, Claudia M DO Nascimento, Lian Tock, Sergio Tufik, Marco T DE Mello, Ana R Damaso
BACKGROUND: Homeostasis Model Assessment-Adiponectin (HOMA-AD) is suggesting a new biomarker of insulin resistance in obese population. In this way, the purpose of this study was to investigate the effects of different kinds of exercise in the sensitive index predictor of insulin resistance. METHODS: A total of 148 obese adolescents were enrolled in the program. They aged 15- 19y, with body mass index (BMI) ≥ P95th and were submitted to 1 year of interdisciplinary weight loss therapy, randomized in two groups, aerobic training (n=51) and aerobic plus resistance training (n=97)...
July 6, 2016: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/27383935/analysis-of-the-stability-of-housekeeping-gene-expression-in-the-left-cardiac-ventricle-of-rats-submitted-to-chronic-intermittent-hypoxia
#16
Guilherme Silva Julian, Renato Watanabe de Oliveira, Sergio Tufik, Jair Ribeiro Chagas
Obstructive sleep apnea (OSA) has been associated with oxidative stress and various cardiovascular consequences, such as increased cardiovascular disease risk. Quantitative real-time PCR is frequently employed to assess changes in gene expression in experimental models. In this study, we analyzed the effects of chronic intermittent hypoxia (an experimental model of OSA) on housekeeping gene expression in the left cardiac ventricle of rats. Analyses via four different approaches-use of the geNorm, BestKeeper, and NormFinder algorithms; and 2-ΔCt (threshold cycle) data analysis-produced similar results: all genes were found to be suitable for use, glyceraldehyde-3-phosphate dehydrogenase and 18S being classified as the most and the least stable, respectively...
May 2016: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/27345144/effects-of-experimental-sleep-deprivation-on-anxiety-like-behavior-in-animal-research-systematic-review-and-meta-analysis
#17
REVIEW
Gabriel Natan Pires, Andréia Gomes Bezerra, Sergio Tufik, Monica Levy Andersen
Increased acute anxiety is a commonly reported behavioral consequence of sleep deprivation in humans. However, rodent studies conducted so far produced inconsistent results, failing to reproduce the same sleep deprivation induced-anxiety observed in clinical experiments. While some presented anxiogenesis as result of sleep deprivation, others reported anxiolysis. In face of such inconsistencies, this article explores the effects of experimental sleep deprivation on anxiety-like behavior in animal research through a systematic review and a series of meta-analyses...
September 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27321086/the-nosas-score-for-screening-of-sleep-disordered-breathing-a-derivation-and-validation-study
#18
Helena Marti-Soler, Camila Hirotsu, Pedro Marques-Vidal, Peter Vollenweider, Gérard Waeber, Martin Preisig, Mehdi Tafti, Sergio Brasil Tufik, Lia Bittencourt, Sergio Tufik, José Haba-Rubio, Raphael Heinzer
BACKGROUND: Diagnosis of sleep-disordered breathing requires overnight recordings, such as polygraphy or polysomnography. Considering the cost and low availability of these procedures, preselection of patients at high risk is recommended. We aimed to develop a screening tool allowing identification of individuals at risk of sleep-disordered breathing. METHODS: We used the participants from the population-based HypnoLaus cohort in Lausanne, Switzerland, who had a clinical assessment and polysomnography at home, to build a clinical score (the NoSAS score) using multiple factor analysis and logistic regression to identify people likely to have clinically significant sleep-disordered breathing...
September 2016: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/27228081/upper-airway-resistance-syndrome-patients-have-worse-sleep-quality-compared-to-mild-obstructive-sleep-apnea
#19
Luciana Balester Mello de Godoy, Gabriela Pontes Luz, Luciana Oliveira Palombini, Luciana Oliveira E Silva, Wilson Hoshino, Thaís Moura Guimarães, Sergio Tufik, Lia Bittencourt, Sonia Maria Togeiro
PURPOSE: To compare sleep quality and sustained attention of patients with Upper Airway Resistance Syndrome (UARS), mild Obstructive Sleep Apnea (OSA) and normal individuals. METHODS: UARS criteria were presence of excessive daytime sleepiness (Epworth Sleepiness Scale-ESS-≥ 10) and/or fatigue (Modified Fatigue Impact Scale-MFIS-≥ 38) associated to Apnea/hypopnea index (AHI) ≤ 5 and Respiratory Disturbance Index (RDI) > 5 events/hour of sleep or more than 30% of total sleep time with flow limitation...
2016: PloS One
https://www.readbyqxmd.com/read/27221315/control-of-stress-induced-acth-secretion-by-vasopressin-and-crh-additional-evidence
#20
Adriana T Ramos, Sergio Tufik, Lanfranco R P Troncone
Vasopressin and CRH have complementary roles in the secretion of ACTH following different stress modalities. The concomitant use of V1b and CRF1 receptor antagonists completely inhibits ACTH secretion in response to different stress modalities. The combination of the CRF1 antagonist SSR125543 with the V1b antagonist SSR149415 effectively suppressed plasma ACTH 1.30 h after injection in rats stressed by ether vapor inhalation for 1 min, restraint stress for 1 h or forced swimming for 5 min. The duration of the effect was also studied...
2016: Neuropsychobiology
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