keyword
https://read.qxmd.com/read/37946726/radiation-induced-undifferentiated-malignant-pituitary-tumor-after-5-years-of-treatment-for-cushing-disease
#21
Gazal Bakshi, Sunil Kumar Mishra, Vishnupriya Ar, Virendera Pal Singh
The occurrence of a second neoplasm possibly constitutes an adverse and uncommon complication after radiotherapy. The incidence of a second pituitary tumor in patients irradiated for adrenocorticotropic hormone secreting pituitary adenoma is rare. We report a case of a 40-year-old female with Cushing disease who underwent surgical management followed by radiotherapy. After 5 years of initial treatment, an increase in tumor size was evident at the same location, with a significant interval growth of the parasellar component of the lesion...
November 2023: JCEM Case Rep
https://read.qxmd.com/read/37940745/endoscopic-endonasal-surgery-for-prolactinomas-prognostic-factors-for-disease-control-and-management-of-persistent-disease
#22
JOURNAL ARTICLE
Aristotelis Kalyvas, Joao Paulo Almeida, Farshad Nassiri, Ruth Lau, Philip J O'Halloran, Nilesh Mohan, Thomas Wälchli, Vincent C Ye, Dennis M Tang, Pranay Soni, Tamia Potter, Shereen Ezzat, Varun R Kshettry, Gelareh Zadeh, Pablo F Recinos, Fred Gentili
Only a limited number of studies have focused on the results of the Endoscopic Endonasal Approach (EEA) for treatment of prolactinomas. We sought to assess the effectiveness of EEA for prolactinoma surgery, identify factors for disease remission, and present our approach for the management of persistent disease. Forty-seven prolactinomas operated over 10 years, with a mean follow-up of 59.9 months, were included. The primary endpoints were early disease remission and remission at last follow-up. Resistance/intolerance to DA were surgical indications in 76...
November 9, 2023: Neurosurgical Review
https://read.qxmd.com/read/37940504/radiotherapy-and-mortality-in-pituitary-adenomas
#23
JOURNAL ARTICLE
Baldomero González-Virla, Guadalupe Vargas-Ortega, Carlos Alfonso Romero-Gameros
BACKGROUND: Pituitary adenomas (PA), comprising 10-20% of intracranial tumors, are classified as functioning and non-functioning and are further divided by size. Non-functioning tumors cause mechanical symptoms while functioning ones result in hormonal hypersecretion syndromes. Initial treatment involves surgery, with medical treatment for prolactinomas. Radiotherapy (RT) is employed as an adjuvant treatment, with various modalities including conventional, stereotactic radiosurgery (SRS), and fractionated stereotactic RT (FSRT)...
November 6, 2023: Archives of Medical Research
https://read.qxmd.com/read/37926781/key-ct-and-mri-findings-of-drug-associated-hepatobiliary-and-pancreatic-disorders
#24
REVIEW
Shintaro Ichikawa, Satoshi Goshima
Obtaining an imaging diagnosis of various hepatobiliary and pancreatic disorders caused by certain drugs can often be challenging. Familiarity with these conditions may improve diagnostic accuracy and patient management. This review aimed to describe the imaging findings of drug-associated hepatobiliary and pancreatic disorders and identify suggestions for obtaining a correct diagnosis. We focused on relatively common disorders or those that can present with characteristic imaging findings, such as drug-induced acute hepatitis, sinusoidal obstruction syndrome, focal nodular hyperplasia-like lesions, hepatocellular adenoma, pseudocirrhosis, chemotherapy-associated steatohepatitis, amiodarone deposition in the liver, secondary iron overload, drug-induced pancreatitis, pancreatic enlargement after epoprostenol therapy, ceftriaxone-associated gallbladder pseudolithiasis, immune-related adverse events, and methotrexate-associated lymphoproliferative disorders...
November 6, 2023: Japanese Journal of Radiology
https://read.qxmd.com/read/37908695/promising-outcomes-in-acromegaly-patients-receiving-cyberknife-stereotactic-hypofractionated-radiotherapy
#25
JOURNAL ARTICLE
Rasim Meral, Ozlem S Selcukbiricik, Ayse K Uzum, Serdar Sahin, Murat Okutan, Mehmet Barburoglu, Ilyas Dolas, Musa Altun, Sema Yarman, Pinar Kadıoglu
BACKGROUND: The primary treatment for patients with acromegaly has traditionally been transsphenoidal surgery, with decreasing reliance on radiotherapy (RT) due to advancements in pharmacotherapy (PT). Despite these advancements, a substantial portion of patients still face persistent acromegaly, necessitating novel treatment approaches. This study investigates the role of CyberKnife Stereotactic Hypofractionated Radiotherapy (CK-HFRT) in persistent acromegaly. OBJECTIVE: The primary objective was to assess the impact of CK-HFRT on endocrine remission (ER) rates while maintaining acceptable toxicity levels...
October 2023: Curēus
https://read.qxmd.com/read/37908013/pituitary-macroadenomas-in-childhood-and-adolescence-a-clinical-analysis-of-7-patients
#26
JOURNAL ARTICLE
Cristina Aguilar-Riera, María Clemente, Núria González-Llorens, Eduard Mogas, Ariadna Campos-Martorell, Anna Fàbregas, Betina Biagetti, Elida Vázquez, Diego Yeste
BACKGROUND: Pituitary adenomas (PPAs) are uncommon in childhood and adolescence, accounting for 2-6% of all intracranial neoplasms. Delayed puberty, growth retardation, galactorrhea and weight gain are common features at presentation in pediatric patients. Functional tumors constitute a vast majority (90%) of PPAs, with the most frequent being prolactinomas. CASE PRESENTATION: A retrospective review of the clinical features and outcomes of 7 pediatric patients with pituitary macroadenomas was conducted...
October 31, 2023: Clinical Diabetes and Endocrinology
https://read.qxmd.com/read/37886631/intracranial-germinoma-combined-with-parathyroid-adenoma-in-a-male-pediatric-patient-a-case-report
#27
Tingting Zhang, Chuanjie Yuan, Juanjuan Lv, Ying Liu, Jin Wu
Cases of young patients combined with intracranial germinoma and parathyroid adenoma are extremely rare. A 6.25-year-old boy was diagnosed with growth hormone deficiency at his first visit and was then treated with growth hormone substitution. Later, he was clinically diagnosed with central diabetes insipidus (CDI) and primary hyperparathyroidism, whereas no abnormal imaging evidence was identified, except for a thickened pituitary stalk. Due to persistent follow-up, parathyroid adenoma and intracranial germinoma were verified in succession...
2023: SAGE Open Medical Case Reports
https://read.qxmd.com/read/37883878/supra-sellar-granular-cell-tumor-report-of-a-case-with-literature-review
#28
Farah Sassi, Alia Zehani, Abdelhafidh Slimane, Imed Ben Said, Khedija Bellil, Slim Haouet
INTRODUCTION AND IMPORTANCE: Granular cell tumor (GCT) originating from the sellar and suprasellar regions, specifically from the neurohypophysis, is a rare neoplasm. Distinguishing GCT from other pituitary tumors, including pituitary adenoma, pituicytoma, and spindle cell oncocytoma, poses significant challenges. Here, we present a rare case of GCT originating from the posterior pituitary in the supra-sellar region. CASE PRESENTATION: A 41-year-old woman, with no past medical history, presented to neurology department with decreased visual acuity and peripheral facial paralysis since 3 months...
November 2023: International Journal of Surgery Case Reports
https://read.qxmd.com/read/37822603/intensity-modulated-radiotherapy-for-cushing-s-disease-single-center-experience-in-70-patients
#29
JOURNAL ARTICLE
Xin Lian, Zhuoran Xu, Shuai Sun, Weiping Wang, Huijuan Zhu, Lin Lu, Xiaorong Hou, Fuquan Zhang
CONTEXT: Intensity-modulated radiotherapy (IMRT) is a modern precision radiotherapy technique for the treatment of the pituitary adenoma. OBJECTIVE: Aim to investigate the efficacy and toxicity of IMRT in treating Cushing's Disease (CD). METHODS: 70 of 115 patients with CD treated with IMRT at our institute from April 2012 to August 2021 were included in the study. The radiation doses were usually 45-50 Gy in 25 fractions. After IMRT, endocrine evaluations were performed every 6 months and magnetic resonance imaging (MRI) annually...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/37796342/radiotherapy-for-benign-diseases-in-turkey-a%C3%A2-patterns-of-care-survey-of-the-turkish-society-for-radiation-oncology-trod-05-002
#30
JOURNAL ARTICLE
Halil Cumhur Yıldırım, Fazilet Öner Dinçbaş, Volkan Demircan, Murat Beyzadeoğlu, Ertuğrul Tekçe, Gözde Yazıcı, Menekşe Turna, Oğuz Çetinayak, Kudret Ensarioğlu Baktır, Mustafa Akın, Emine Canyılmaz, Ayse Altınok, Ela Delikgöz Soykut, Müge Akmansu, Fuzuli Tuğrul, Seda Ünverdi, Berrin Benli Yavuz, Serra Kamer, Mürsel Düzova, Sumerya Duru Birgi, Emine Elif Özkan, Berrin Yalçın, Merve Şahin, Durmuş Etiz, Hasan Suat Arslantaş, Deniz Meydan, Şefik İğdem, Halil Sağınç, Murtaza Parvizi, Pelin Altınok, Yavuz Anacak
PURPOSE: We aimed to investigate the patterns of radiotherapy (RT) care in cases of benign diseases in Turkey. METHODS: A questionnaire survey was sent to all radiation oncology (RO) departments in Turkey. The number of patients treated for benign disease between 2015 and 2020 was requested. A list of benign conditions was given, and information on the number of patients per disease, single and total doses prescribed, weekly fractions, radiation type, energy, and device was requested...
October 5, 2023: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://read.qxmd.com/read/37796263/-salivary-gland-neoplasms
#31
JOURNAL ARTICLE
Florian Chatelet
SALIVARY GLAND NEOPLASMS. Salivary gland tumors represent a heterogeneous group of lesions, with various anatomical locations. The most frequent site of involvement is the parotid, and the most frequent histology is pleomorphic adenoma, a benign tumor with the potential for recurrence and malignant transformation. Approximately one third of tumors are malignant, and the prognosis depends on the tumor histology and histoprognostic criteria. The diagnostic strategy focuses on determining the benignity or malignancy of these lesions to choose appropriate treatment...
September 2023: La Revue du Praticien
https://read.qxmd.com/read/37782323/results-from-a-global-multicenter-registry-of-6193-patients-to-refine-endoscopic-anatomical-enucleation-of-the-prostate-reap-by-evaluating-trends-and-outcomes-and-nuances-of-prostate-enucleation-in-a-real-world-setting
#32
MULTICENTER STUDY
Vineet Gauhar, Fernando Gómez Sancha, Dmitry Enikeev, Mario Sofer, Khi Yung Fong, Moisés Rodríguez Socarrás, Dean Elterman, Mallikarjuna Chiruvella, Mohammed Taif Bendigeri, Azimdjon N Tursunkulov, Abhay Mahajan, Tanuj Paul Bhatia, Sorokin Nikolai Ivanovich, Nariman Gadzhiev, Lie Kwok Ying, Biligere Sarvajit, Marco Dellabella, Vladislav Petov, Bhaskar Kumar Somani, Daniele Castellani, Thomas R W Herrmann
PURPOSE: To collect a multicentric, global database to assess current preferences and outcomes for endoscopic enucleation of the prostate (EEP). METHODS: Endourologists experienced in EEP from across the globe were invited to participate in the creation of this retrospective registry. Surgical procedures were performed between January 2020 and August 2022. INCLUSION CRITERIA: lower urinary tract symptoms not responding to or worsening despite medical therapy and absolute indication for surgery...
November 2023: World Journal of Urology
https://read.qxmd.com/read/37757941/early-versus-delayed-fractionated-stereotactic-radiotherapy-for-nonfunctioning-pituitary-adenoma
#33
JOURNAL ARTICLE
Anish V Sathe, Alan Siu, KiChang Kang, Allison Kayne, Shreya Vinjamuri, Patrick Kelly, Wenyin Shi, James J Evans, Christopher J Farrell
BACKGROUND: Fractionated stereotactic radiotherapy (FSRT) is a common modality used to treat pituitary adenomas with good control rates. It is currently unknown whether FSRT should be performed early or delayed until progression occurs. OBJECTIVE: We compared FSRT in treating non-functional pituitary adenomas (NFPA) as an adjuvant (ADJ) or on-progression (PRG) therapy. METHODS: A retrospective review of patients who underwent FSRT for a NFPA between January 2004 to December 2022 at a single institution was performed...
September 25, 2023: World Neurosurgery
https://read.qxmd.com/read/37742355/a-solitary-fibrous-tumor-of-the-parotid-gland-case-report
#34
Carmelo Saraniti, Davide Burrascano, Barbara Verro, Giovanni De Lisi, Vito Rodolico
INTRODUCTION: Solitary fibrous tumor is a rare neoplasm that can affect any part of the body, also head and neck region. Etiology is unknown. The incidence is slightly higher in males, the age ranges from 11 to 79 years. PRESENTATION OF CASE: It's the first case in our country of left parotid solitary fibrous tumor, removed by partial parotidectomy with facial nerve preservation. Histology examination showed diffuse spindle-shaped cells proliferation, moderate polymorphism, low mitotic index (<4 mitoses per 10 HPF), partially bordered by fibrous capsule...
September 22, 2023: International Journal of Surgery Case Reports
https://read.qxmd.com/read/37741079/reconstruction-with-facial-artery-musculo-mucosal-flap-famm-f-after-resection-of-upper-lip-pleomorphic-adenoma-case-report
#35
Amirmohsen Jalaeefar, Hana Saffar, Mohammad Shirkhoda, Ata Garajei, Amirsina Sharifi
INTRODUCTION: Although pleomorphic adenoma (PA) is the most common neoplasm of both minor and major salivary glands, its presence in the buccal surface of upper lip is rare. PRESENTATION OF CASE: A 70-year-old male presented with a chief complaint of recent rapid growth of a mass in the buccal aspect of the upper lip. A well-circumscribed mass measuring 3 × 2 cm with intact overlying mucosa without regional lymphadenopathy was evident. Core needle biopsy report was suggestive of PA...
September 14, 2023: International Journal of Surgery Case Reports
https://read.qxmd.com/read/37720528/efficacy-and-safety-of-temozolomide-in-the-treatment-of-aggressive-pituitary-neuroendocrine-tumours-in-spain
#36
JOURNAL ARTICLE
Cristina Lamas, Rosa Cámara, Carmen Fajardo, Pablo Remon-Ruiz, Betina Biagetti, Fernando Guerrero-Pérez, Marta Araujo-Castro, Mireia Mora, Felicia Hanzu, Pedro Iglesias, Rogelio García-Centeno, Alfonso Soto
Current guidelines recommend temozolomide as the first-line chemotherapy for aggressive pituitary neuroendocrine tumours. However, no clinical trials have been conducted to date and clinical experience is quite limited. We retrospectively analyzed 28 patients (9 women and 19 men), aged 46.6 + 16.9, with aggressive pituitary tumours (4 pituitary carcinomas and 24 aggressive adenomas) treated with temozolomide in 10 Spanish pituitary reference centres. Four patients had Cushing's disease, 9 prolactinomas and 15 clinically non-functioning pituitary tumours (seven silent corticotroph, three silent somatotroph, one silent lactotroph, one silent gondotroph and three null-cell tumours)...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/37711900/the-clinical-and-therapeutic-profiles-of-prolactinomas-associated-with-germline-pathogenic-variants-in-the-aryl-hydrocarbon-receptor-interacting-protein-aip-gene
#37
JOURNAL ARTICLE
Laurent Vroonen, Albert Beckers, Severine Camby, Thomas Cuny, Pablo Beckers, Marie-Lise Jaffrain-Rea, Muriel Cogne, Luciana Naves, Amandine Ferriere, Pauline Romanet, Atanaska Elenkova, Auli Karhu, Thierry Brue, Anne Barlier, Patrick Pétrossians, Adrian F Daly
INTRODUCTION: Prolactinomas are the most frequent type of pituitary adenoma encountered in clinical practice. Dopamine agonists (DA) like cabergoline typically provide sign/ symptom control, normalize prolactin levels and decrease tumor size in most patients. DA-resistant prolactinomas are infrequent and can occur in association with some genetic causes like MEN1 and pathogenic germline variants in the AIP gene (AIPvar). METHODS: We compared the clinical, radiological, and therapeutic characteristics of AIPvar-related prolactinomas (n=13) with unselected hospital-treated prolactinomas ("unselected", n=41) and genetically-negative, DA-resistant prolactinomas (DA-resistant, n=39)...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/37625240/efficacy-of-pd-1-inhibitors-for-colorectal-cancer-and-polyps-in-lynch-syndrome-patients
#38
JOURNAL ARTICLE
Jie-Hai Yu, Bin-Yi Xiao, Jing-Hua Tang, Dan-Dan Li, Fang Wang, Ya Ding, Kai Han, Ling-Heng Kong, Yi-Hong Ling, Wei-Jian Mei, Zhi-Gang Hong, Le-En Liao, Wan-Jun Yang, Zhi-Zhong Pan, Xiao-Shi Zhang, Wu Jiang, Pei-Rong Ding
BACKGROUND: Programmed death-1 (PD-1) inhibitor is effective for colorectal cancer (CRC) with deficient mismatch repair (dMMR) or high microsatellite instability (MSI-H). We aimed to explore its effects on CRCs and colonic polyps in Lynch syndrome (LS) patients. METHODS: LS patients with CRC who had evaluable tumours and received at least 2 cycles of PD-1 inhibitors were retrospectively included. PD-1 inhibitors were given as a monotherapy or in combination with other therapies, including anticytotoxic T-lymphocyte-associated antigen-4 treatment, radiotherapy, chemotherapy, and targeted therapy...
October 2023: European Journal of Cancer
https://read.qxmd.com/read/37584889/the-potential-link-between-acromegaly-and-risk-of-acute-ischemic-stroke-in-patients-with-pituitary-adenoma-a-new-perspective
#39
REVIEW
Saud A Alnaaim, Hayder M Al-Kuraishy, Mohammad Mitran Zailaie, Athanasios Alexiou, Marios Papadakis, Hebatallah M Saad, Gaber El-Saber Batiha
Acromegaly is an endocrine disorder due to the excess production of growth hormone (GH) from the anterior pituitary gland after closed epiphyseal growth plates. Acromegaly is mainly caused by benign GH-secreting pituitary adenoma. Acute ischemic stroke (AIS) is one of the most common cardiovascular complications. It ranks second after ischemic heart disease (IHD) as a cause of disability and death in high-income countries globally. Thus, this review aimed to elucidate the possible link between acromegaly and the development of AIS...
August 16, 2023: Acta Neurologica Belgica
https://read.qxmd.com/read/37579837/position-statement-on-the-diagnosis-and-management-of-acromegaly-the-french-national-diagnosis-and-treatment-protocol-ndtp
#40
Thierry Brue, Haïfa Rahabi, Abdoulaye Barry, Anne Barlier, Jérôme Bertherat, Françoise Borson-Chazot, Frédéric Castinetti, Laure Cazabat, Olivier Chabre, Nicolas Chevalier, Sophie Christin-Maitre, Christine Cortet, Delphine Drui, Peter Kamenicky, Catherine Lançon, Frédéric Lioté, Isabelle Pellegrini, Rachel Reynaud, Sylvie Salenave, Igor Tauveron, Philippe Touraine, Marie-Christine Vantyghem, Bruno Vergès, Delphine Vezzosi, Chiara Villa, Gérald Raverot, Régis Coutant, Philippe Chanson, Frederique Albarel
Acromegaly is a rare disease with prevalence of approximately 60 cases per million, slight female predominance and peak onset in adults in the fourth decade. Clinical diagnosis is often delayed by several years due to the slowly progressive onset of symptoms. There are multiple clinical criteria that define acromegaly: dysmorphic syndrome of insidious onset, symptoms related to the pituitary tumor (headaches, visual disorders), general signs (sweating, carpal tunnel syndrome, joint pain, etc.), complications of the disease (musculoskeletal, cardiovascular, pneumological, dental, metabolic comorbidities, thyroid nodules, colonic polyps, etc...
August 12, 2023: Annales D'endocrinologie
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