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https://www.readbyqxmd.com/read/29450811/debulking-surgery-of-pituitary-adenoma-as-a-strategy-to-facilitate-definitive-stereotactic-radiosurgery
#1
Neil Forster, Ronald Warnick, Vinita Takiar, Luke Pater, John Breneman
In patients with pituitary adenomas (PA) who are unable to undergo complete surgical resection, radiation therapy (RT), specifically stereotactic radiosurgery (SRS), results in excellent local control. However, the utility of radiosurgery may be limited by the proximity of the lesion to the optic chiasm (OC). We evaluate the efficacy of debulking surgery in increasing the PA-OC separation to convert patients into SRS candidates. From 2007 to 2015, 31 patients with PA < 2 mm from the OC underwent debulking surgery followed by RT within 2 years of resection...
February 15, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29396062/sellar-plasmacytomas-masquerading-as-pituitary-adenomas-a-systematic-review
#2
REVIEW
Joseph DiDomenico, Leonel Ampie, Winward Choy, Jonathan B Lamano, Daniel E Oyon, Kartik Kesavabhotla, Orin Bloch
Given the rarity of intracranial plasmacytomas, these lesions are frequently misdiagnosed as pituitary adenomas. We report on the distinguishing characteristics of sellar plasmacytomas from cases in the literature and our experience. A literature search was conducted to collect all documented cases of a plasmacytoma originating in the sellar region. Patient characteristics, medical history, presentation, tumor characteristics, and survival data were collected. An additional case from our institution not previously reported was included...
January 22, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29382618/primary-meningeal-melanocytoma-in-sellar-region-simulating-a-nonfunctioning-pituitary-adenoma-a-case-report-and-literature-review
#3
Fei Wang, Shiying Ling
BACKGROUND: and Importance Primary meningeal melanocytoma (PMM) is a benign lesion in the central nervous system derived from leptomeningeal melanocytes, most commonly growing in the posterior fossa and cervical spinal cord. The primary sellar melanocytoma is an exceptionally rare tumor. The authors reported the ninth published case of a sellar primary meningeal melanocytoma (SPMM). CLINICAL PRESENTATION: The patient presented only with visual impairment and irregular menstruation without other symptoms...
January 27, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29372392/management-of-nonfunctioning-pituitary-tumors-radiotherapy
#4
REVIEW
Giuseppe Minniti, John Flickinger, Barbara Tolu, Sergio Paolini
External beam radiotherapy (RT) is an essential part of the management of intracranial tumors and has been used in treating pituitary adenomas for more than five decades. It has been demonstrated that conventional RT for postoperative residual or progressive nonfunctioning pituitary adenomas (NFAs) present an excellent long-term local tumor control, although its use has been limited because of the potential late toxicity related to radiation treatments. Recent advances in radiation techniques have led to more accurate treatments, rendering obsolete many commonly held views of the "old" radiotherapy...
January 25, 2018: Pituitary
https://www.readbyqxmd.com/read/29355797/cyberknife-radiosurgery-in-the-multimodal-management-of-patients-with-cushing-s-disease
#5
Justin M Moore, Elisa Sala, Alvaro Amorin, Hector Martinez, Aprotim C Bhowmik, Steven D Chang, Scott G Soltys, Griffith R Harsh, Laurence Katznelson
OBJECTIVE: Surgery is the primary treatment for Cushing's disease (CD). However, when surgery is not successful at normalizing hypercortisolism, adjuvant radiation, such as stereotactic radiosurgery (SRS), may be useful to improving biochemical control. METHODS: We completed a retrospectively cohort study of consecutively treated patients with CyberKnife (CK) radiosurgery for active CD at Stanford Hospital and Clinics. RESULTS: As first line treatment, all patients underwent transsphenoidal surgery with histological demonstration of an adrenocorticotropic hormone (ACTH) producing pituitary adenoma...
January 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29342030/mesenchymal-chondrosarcoma-of-the-lacrimal-gland
#6
Hayyam Kiratli, Yağmur Deniz, Berrin Büyükeren, Gökhan Gedikoğlu
A 23-year-old woman presented with right-sided painless proptosis that developed in 12 months. MRI studies demonstrated a well-delineated tumorous enlargement of the right lacrimal gland with homogenous signal intensity and compressing the globe. The tumor was removed totally and in 1 piece with the tentative diagnosis of a pleomorphic adenoma. Pathologic examination revealed biphasic neoplastic elements, which were composed of the cartilaginous matrix and small round cell component. Immunohistopathological examination showed positive CD99 staining and negative reaction to S100, panCK, and CD15...
January 16, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29299820/malignant-transformation-in-non-functioning-pituitary-adenomas-pituitary-carcinoma
#7
REVIEW
Nèle Lenders, Ann McCormack
Non-functioning pituitary carcinomas (NFPC) are defined as tumours of adenophyseal origin with craniospinal or systemic dissemination, with the absence of a hormonal hypersecretion syndrome. These are a histologically heterogenous group of tumours, comprising gonadotroph, null cell, "silent" tumours of corticotroph, somatotroph or lactotroph cell lineages as well as plurihormonal Pit-1 tumours. NFPC are exceedingly rare, and hence few cases have been described. This review has identified 38 patients with NFPC reported in the literature...
January 3, 2018: Pituitary
https://www.readbyqxmd.com/read/29278551/the-recurrent-pleomorphic-adenoma-conundrum
#8
Patrick J Bradley
PURPOSE OF REVIEW: Recurrent pleomorphic adenoma (RPA) is uncommon. Treatment selection is based on the likely possibility of minimizing the risk of tumour recurrence, avoiding local functional and cosmetic sequelae, and eradicates the possibility of metastatic or malignant transformation. Much has changed since the topic was reviewed in 2001, and this manuscript comments on clinical progress and discusses patient treatment options. RECENT FINDINGS: Surgery is the preferred treatment for head and neck pleomorphic adenoma...
December 22, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/29170844/early-recognition-of-aggressive-pituitary-adenomas-a-single-centre-experience
#9
Filippo Ceccato, Daniela Regazzo, Mattia Barbot, Luca Denaro, Enzo Emanuelli, Daniele Borsetto, Giuseppe Rolma, Luigi Alessio, Marina Paola Gardiman, Giuseppe Lombardi, Nora Albiger, Domenico D'Avella, Carla Scaroni
BACKGROUND: Pituitary adenomas are usually considered benign tumours, although some of them can exhibit an aggressive behaviour. Patients with clinically aggressive pituitary adenomas are frequently diagnosed with larger masses, and may present an earlier recurrence (or persistence) after surgery. Our aim was to characterise the clinical, histopathological and radiological features of patients with aggressive pituitary adenoma, in order to correlate their clinical behaviour with the response to treatment plan...
January 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29143959/intracapsular-carcinoma-ex-pleomorphic-adenoma-of-the-parapharyngeal-space-report-of-two-cases-and-review-of-the-literature
#10
Remo Accorona, Diego Barbieri, Davide Farina, Davide Lombardi, Mario Bussi, Piero Nicolai
BACKGROUND: Carcinoma ex-pleomorphic adenoma of the parapharyngeal space is an exceedingly rare entity. METHODS: The clinical records of two patients with primary carcinoma ex-pleomorphic adenoma of the parapharyngeal space surgically treated at two different centers were retrospectively analyzed. RESULTS: Despite ultrasound-guided fine-needle aspiration cytology and magnetic resonance imaging, the correct diagnosis was preoperatively missed in both cases...
November 15, 2017: Tumori
https://www.readbyqxmd.com/read/29022276/diagnosis-and-treatment-of-tsh-secreting-adenomas-review-of-a-longtime-experience-in-a-reference-center
#11
D M Nazato, J Abucham
PURPOSE: TSH-secreting pituitary adenomas are among the less prevalent pituitary tumors, corresponding to 0.9-1.5% of all pituitary adenomas in surgical series. METHODS: A series of 11 patients with TSH-secreting and cosecreting adenomas diagnosed and treated in the last 25 years in a single center is described. RESULTS: The mean age at diagnosis was 37 years (range 18-80 years; median 23 years); the ratio of male-to-female patients was similar (6M:5F)...
October 11, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28955679/polymorphous-low-grade-adenocarcinoma-of-the-parotid-in-a-teenager
#12
Divya Khosla, Shalini Verma, Nitin Gupta, Rajpal-S Punia, Gurbir Kaur, Awadhesh-K Pandey, Kislay Dimri
INTRODUCTION: Polymorphous low grade adenocarcinoma (PLGA) is a rare salivary gland neoplasm with an indolent course. It occurs primarily in the minor salivary glands but can rarely occur in the major salivary glands. It usually occurs in the fifth to seventh decades of life with female preponderance. CASE REPORT: A 16-year-old male presented with recurrent painless swelling in the right preauricular region and with a history of surgical intervention at the same site in the past...
September 2017: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28913704/impact-of-etiology-age-and-gender-on-onset-and-severity-of-hyponatremia-in-patients-with-hypopituitarism-retrospective-analysis-in-a-specialised-endocrine-unit
#13
Dragana Miljic, Mirjana Doknic, Marko Stojanovic, Marina Nikolic-Djurovic, Milan Petakov, Vera Popovic, Sandra Pekic
BACKGROUND: Hyponatremia can unmask hypopituitarism and secondary adrenal insufficiency. This is important, since the need to screen for steroid deficiency, in patients with hyponatremia is often neglected. PATIENTS AND METHODS: In a retrospective study, twenty-five patients (13f/12m, age 58.9 ± 18.6 years) with hyponatremia (119.7 ± 10.5 mmol/L) were identified among 260 in-patients treated for hypopituitarism in our specialized endocrine unit, over the last decade...
November 2017: Endocrine
https://www.readbyqxmd.com/read/28855848/primary-breast-angiosarcoma-a-rare-presentation-of-rare-tumor-case-report
#14
Fayçal Abbad, Najat Cherif Idrissi, Btissam Fatih, Bouchra Fakhir, Jamal Drissi, Mouna Khouchani, Hanane Rais
BACKGROUND: Primary breast angiosarcoma is defined as malignant proliferation showing endothelial differentiation. It is a very rare tumour (0.05% of primary mammary cancers), whose diagnosis can be difficult. CASE PRESENTATION: We report the observation of a patient with no previous history, aged 27 years. The clinical examination finds a right breast discreetly increased in volume. The trucut biopsy was in favour of a lactating tubular adenoma. However, an immunohistochemical complement was requested...
2017: BMC Clinical Pathology
https://www.readbyqxmd.com/read/28832172/-metastatic-pituitary-disorders
#15
V Novák, L Hrabálek, M Hampl, J Hoza, Z Fryšák, M Vaverka
BACKGROUND: Pituitary metastases are a rare complication of generalized cancer. Metastases to the pituitary gland occur in only 1% of patients operated on for sellar tumor. The most common presenting symptom in patients with pituitary metastases is diabetes insipidus, whereas this is rare in those with pituitary adenoma. MATERIAL AND METHODS: This publication presents the cases of two patients with pituitary metastases and a systematic review of the literature. English-language publications related to pituitary metastases and published from 1957 to 2016 were identified using the PubMed database...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28831662/pituitary-apoplexy-and-rivaroxaban
#16
S Ly, A Naman, B Chaufour-Higel, M Patey, C Arndt, B Delemer, C F Litre
Pituitary apoplexy (PA), defined by the occurrence of a massive hemorrhagic necrotic rearrangement within a pituitary adenoma, is rare. Its occurrence can be associated with certain risk factors, including anticoagulation. We report the first case of PA with rivaroxaban which is one of the new oral anticoagulants: a 73 year-old patient presenting with severe headache and visual field deterioration. Surgery was performed. Radiotherapy treatment was decided three months after surgery because of tumor residue.
December 2017: Pituitary
https://www.readbyqxmd.com/read/28828496/impact-of-postoperative-radiotherapy-and-her2-new-overexpression-in-salivary-duct-carcinoma-a%C3%A2-monocentric-clinicopathologic-analysis
#17
Marlen Haderlein, Claudia Scherl, Sabine Semrau, Sebastian Lettmaier, Markus Hecht, Ramona Erber, Heinrich Iro, Rainer Fietkau, Abbas Agaimy
AIM: Retrospective Investigation of the prognostic relevance of clinicopathologic parameters in patients with salivary duct carcinoma (SDC). METHODS: An experienced pathologist reviewed 67 patients with de novo SDC or SDC ex pleomorphic adenoma. Paraffin-embedded tumor samples were examined by immunohistochemistry for expression of HER2/neu, androgen (AR), progesterone (PR), estrogen (ER), epidermal growth factor (EGFR) and programmed death ligand 1 (PD-L1-R) receptor...
November 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28796082/the-first-reported-case-of-primary-intestinal-type-adenocarcinoma-of-the-middle-ear-and-review-of-the-literature
#18
Marc-Elie Nader, Diana Bell, Lawrence Ginsberg, Franco DeMonte, G Brandon Gunn, Paul W Gidley
OBJECTIVE: Adenocarcinoma of the middle ear is a rare entity that must be distinguished from other adenomatous tumors of the temporal bone. We present the first patient of an intestinal-type adenocarcinoma originating from the middle ear. PATIENTS: A 58-year-old woman presented with an 8-year history of left otorrhea. Her middle ear effusions were quite thick and gummy. She underwent eight sets of pressure-equalization tubes within 3 years. In 2011, her physical examination identified a middle ear mass, and she underwent mastoidectomy...
October 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28775202/pet-mr-imaging-in-the-diagnosis-of-hormone-producing-pituitary-micro-adenoma-a-prospective-pilot-study
#19
Hao Wang, Bo Hou, Lin Lu, Ming Feng, Jie Zang, Shaobo Yao, Feng Feng, Renzhi Wang, Fang Li, Zhaohui Zhu
Purpose: This study was designed to evaluate positron emission tomography/magnetic resonance (PET/MR), using (18)F-FDG and (68)Ga-DOTATATE as tracers, in the detection of hormone-producing pituitary micro-adenoma, where diagnosis is difficult using magnetic resonance imaging (MRI) alone. Methods: A total of 37 patients with elevated hormone levels were recruited, including 19 patients with undiagnosable primary pituitary tumors and 18 patients with suspected recurrent pituitary adenomas (PAs). Patients underwent (18)F-FDG PET/MR and (68)Ga-DOTATATE PET/MR within one week...
August 3, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28742502/temozolomide-therapy-for-resistant-prolactin-secreting-pituitary-adenomas-and-carcinomas-a-systematic-review
#20
REVIEW
Mussa H Almalki, Nora Nasser Aljoaib, Maha Jurais Alotaibi, Bayan Saloum Aldabas, Tayba Saleh Wahedi, Maswood H Ahmad, Fahad Alshahrani
Pituitary tumors represent 10-15% of all intracranial tumors; of these, prolactinomas account for 40-50% of cases. Prolactinomas usually respond well to dopamine agonists (DA) as first-line therapy. However, treatment resistance remains a concern. Temozolomide (TMZ) is an oral alkylating agent that has shown promise in treating aggressive pituitary adenomas and carcinomas that are resistant to other therapies. To date, no control trials have been undertaken and only single case reports of pituitary tumors treated with TMZ have been published...
April 2017: Hormones: International Journal of Endocrinology and Metabolism
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