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J Detsky, A Kapadia, J Conklin, G Stanisz, A Sahgal, C Heyn, H Soliman
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
P Tiwari, P Prasanna, L Wolansky, M Pinho, M Cohen, A P Nayate, A Gupta, G Singh, K Hattanpaa, A Sloan, L Rogers, A Madabhushi
BACKGROUND AND PURPOSE: Despite availability of advanced imaging, distinguishing radiation necrosis from recurrent brain tumors noninvasively is a big challenge in neuro-oncology. Our aim was to determine the feasibility of radiomic (computer-extracted texture) features in differentiating radiation necrosis from recurrent brain tumors on routine MR imaging (gadolinium T1WI, T2WI, FLAIR). MATERIALS AND METHODS: A retrospective study of brain tumor MR imaging performed 9 months (or later) post-radiochemotherapy was performed from 2 institutions...
September 15, 2016: AJNR. American Journal of Neuroradiology
Catherine N Tchanque-Fossuo, Faranak Kamangar, Baran Ho, Shurong Chang, Sara E Dahle, Joshua M Schulman, R Rivkah Isseroff
Complications from radiation exposure during fluoroscopic guidance of cardiac catheterization may occur. With repeated procedures, the risk for cutaneous injuries increases. Herein, we describe a 59-year-old man with extensive coronary artery disease, who had undergone multiple revascularization procedures and developed a non-healing ulcer on his left inferior scapula. The patient's medical history, physical exam findings, and histopathology gave clues to a case of radiation-induced dermatitis and necrosis.
2016: Dermatology Online Journal
V Guimas, J Thariat, P Graff-Cailleau, P Boisselier, Y Pointreau, P Pommier, X Montbarbon, C Laude, S Racadot
Modern techniques such as intensity modulated radiation therapy (IMRT) have been proven to significantly decrease the dose delivered to the cochleovestibular apparatus, limiting consecutive toxicity especially for sensorineural hearing loss. However, recent data still report a 42% rate of radio-induced hypoacusia underscoring the need to protect the cochleovestibular apparatus. Due to the small size of the cochlea, a precise dose-volume analysis could not be performed, and recommendations only refer to the mean dose...
October 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
I Hartig, I Matveeva, M Braun
Intra-articular radiation synovectomy is an established and well documented therapy in rheumatology. A rare side effect is necrosis of surrounding tissue caused by leakage of the radionuclide.We describe the case of a 34-year old patient with rheumatoid arthritis who developed skin necrosis 4 weeks after an intra-articular radiation synovectomy of the left wrist. When these lesions are recognized early surgical therapy or hyperbaric oxygen therapy can be initiated.
September 2, 2016: Zeitschrift Für Rheumatologie
Jordi Remon, Cécile Le Péchoux, Caroline Caramella, Frederic Dhermain, Guillame Louvel, Jean-Charles Soria, Benjamin Besse
No abstract text is available yet for this article.
August 17, 2016: Journal of Thoracic Oncology
Faliang Gao, Yong Cui, Haihui Jiang, Dali Sui, Yonggang Wang, Zhongli Jiang, Jizong Zhao, Song Lin
Brain glioma is the most common primary intracranial tumor characterized by dismal prognosis and frequent recurrence, yet a real-time and reliable biological approach to monitor tumor response and progression is still lacking. Recently, few studies have reported that circulating tumor cells (CTCs) could be detected in glioblastoma multiform (GBM), providing the possibility of its application in brain glioma monitoring system. But its application limits still exist, because the detection rate of CTCs is still low and was exclusively limited to high- grade gliomas...
August 8, 2016: Oncotarget
J R Garcia, M Cozar, M Baquero, J M Fernández Barrionuevo, A Jaramillo, J Rubio, G Maida, M Soler, E Riera
OBJECTIVE: To evaluate the contribution of (11)C-Methionine PET in the early differentiation between tumour recurrence and radionecrosis in patients treated for a high grade glioma. METHOD: The study included 30 patients with glioma (III/IV grade) treated with surgery/radiotherapy/chemotherapy (5-8 months) and with an indeterminate MRI. All patients underwent a (11)C-Methione PET (within 15 days of MRI) and studies were visually analysed (intensity and morphology of uptake), quantified (SUV max/SUV mean background), and coregistered to MRI (3D-Flair)...
August 6, 2016: Revista Española de Medicina Nuclear e Imagen Molecular
Brandon S Imber, Ishan Kanungo, Steve Braunstein, Igor J Barani, Shannon E Fogh, Jean L Nakamura, Mitchel S Berger, Edward F Chang, Annette M Molinaro, Juan R Cabrera, Michael W McDermott, Penny K Sneed, Manish K Aghi
BACKGROUND: The role of stereotactic radiosurgery (SRS) for recurrent glioblastoma and the radionecrosis risk in this setting remain unclear. OBJECTIVE: To perform a large retrospective study to help inform proper indications, efficacy, and anticipated complications of SRS for recurrent glioblastoma. METHODS: We retrospectively analyzed patients who underwent Gamma Knife SRS between 1991 and 2013. We used the partitioning deletion/substitution/addition algorithm to identify potential predictor covariate cut points and Kaplan-Meier and proportional hazards modeling to identify factors associated with post-SRS and postdiagnosis survival...
July 13, 2016: Neurosurgery
Maria Jesus Lobón, Francisco Bautista, François Riet, Frederic Dhermain, Sandra Canale, Christelle Dufour, Thomas Blauwblomme, Michel Zerah, Kevin Beccaria, Christian Saint-Rose, Stephanie Puget, Christian Carrie, Eric Lartigau, Pierre-Yves Bondiau, Dominique Valteau-Couanet, Jacques Grill, Stephanie Bolle
BACKGROUND: Standard treatment for recurrent ependymomas is not defined. Re- irradiation has been proposed but its modalities and results are still to be explored. PATIENTS AND METHODS: From June 1994 to December 2013, 32 pediatric patients with ependymoma were re-irradiated for local (n = 15) or metastatic (n = 17) relapses. Files were reviewed retrospectively. RESULTS: Local relapses were treated with hypofractionated focal radiotherapy (hypoFFRT) (n = 8) or focal fractionated radiotherapy (FFRT) (n = 7)...
2016: SpringerPlus
Arun Chandran, Shubhabrata Biswas, James Leon Hartley, Hans Christean Nahser, Jeffrey Lancaster, Mani Puthuran
A bleeding vertebral artery pseudoaneurysm is a rare cause of haemoptysis. Pseudoaneurysm can arise due to radionecrosis from previous radiotherapy in the base of skull and neck region and may present with haemoptysis many years later. It is important to be aware of this entity in the work-up of haemoptysis, particularly in patients with previous base of skull and neck radiotherapy. Our patient was successfully treated with endovascular occlusion.
October 2016: Interventional Neuroradiology
Mark Amsbaugh, Jianmin Pan, Mehran B Yusuf, Anthony Dragun, Neal Dunlap, Timothy Guan, Warren Boling, Shesh Rai, Shiao Woo
BACKGROUND: Our aim was to identify a dose-volume response relationship for brain metastases treated with frameless stereotactic radiosurgery (SRS). METHODS: We reviewed patients who underwent frameless single-fraction linear accelerator SRS for brain metastases between 2007 and 2013 from an institutional database. Proportional hazards modeling was used to identify predictors of outcome. A ratio of maximum lesion dose per mm-diameter (Gy/mm) was constructed to establish a dose-volume relationship...
2016: Curēus
Caroline Papin-Michault, Christelle Bonnetaud, Maxime Dufour, Fabien Almairac, Mickael Coutts, Stéphanie Patouraux, Thierry Virolle, Jacques Darcourt, Fanny Burel-Vandenbos
Positron emission tomography using radiolabeled amino acid (PET-AA) appears to be promising in distinguishing between recurrent tumour and radionecrosis in the follow-up of brain metastasis (BM). The amino acid transporter LAT1 and its cofactor CD98, which are involved in AA uptake, have never been investigated in BM. The aim of our study was to determine and compare the expression of LAT1 and CD98 in BM and in non-tumoral brain tissue (NT). The expression of LAT1 and CD98 were studied by immunohistochemistry in 67 BM, including 18 BM recurrences after radiotherapy, in 53 NT, and in 13 cases of patients with previously irradiated brain tumor and investigated by [18F] FDOPA-PET...
2016: PloS One
A Gabriella Wernicke, Andrew W Smith, Shoshana Taube, Menachem Z Yondorf, Bhupesh Parashar, Samuel Trichter, Lucy Nedialkova, Albert Sabbas, Paul Christos, Rohan Ramakrishna, Susan C Pannullo, Philip E Stieg, Theodore H Schwartz
OBJECTIVE Managing patients whose intraparenchymal brain metastases recur after radiotherapy remains a challenge. Intraoperative cesium-131 (Cs-131) brachytherapy performed at the time of neurosurgical resection may represent an excellent salvage treatment option. The authors evaluated the outcomes of this novel treatment with permanent intra-operative Cs-131 brachytherapy. METHODS Thirteen patients with 15 metastases to the brain that recurred after stereotactic radiosurgery and/or whole brain radiotherapy were treated between 2010 and 2015...
June 3, 2016: Journal of Neurosurgery
Sahar M El Khamary, Alicia Galindo-Ferreiro, Patricia Akaishi, Yerena Muiños-Diaz, Sheila P Cechetti, Murilo B Cintra, Antonio Augusto V Cruz
PURPOSE: To describe CT scan findings following orbital exenteration in 27 patients and to identify the factors involved in the development of post exenteration hyperostosis. METHODS: Noncomparative case series. The authors reviewed the charts of 27 patients ranging in age from 33 to 99 years, who underwent unilateral exenteration at King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia and at the School of Medicine of Ribeirão Preto, University of São Paulo, Brazil...
May 31, 2016: Ophthalmic Plastic and Reconstructive Surgery
Omar Bohoudi, Anna M E Bruynzeel, Frank J Lagerwaard, Johan P Cuijpers, Ben J Slotman, Miguel A Palacios
PURPOSE/OBJECTIVE(S): Radionecrosis (RN) has previously been correlated with radiosurgery (RS) dose, lesion volume, and the volume of the brain receiving specific doses, i.e. V10-14Gy. A knowledge-based individualized estimation of the optimum RS dose has been derived based on lesional volume and brain toxicity parameters. METHODS AND MATERIALS: A prediction model for brain toxicity parameters and estimation of the optimum RS dose was derived using 30 historical linac-based dynamic conformal arc RS plans for single brain metastases (BM) (0...
August 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Giuseppe Minniti, Claudia Scaringi, Sergio Paolini, Gaetano Lanzetta, Andrea Romano, Francesco Cicone, Mattia Osti, Riccardo Maurizi Enrici, Vincenzo Esposito
PURPOSE: To investigate the local control and radiation-induced brain necrosis in patients with brain metastases >2 cm in size who received single-fraction or multifraction stereotactic radiosurgery (SRS); factors associated with clinical outcomes and the development of brain radionecrosis were assessed. METHODS AND MATERIALS: Two hundred eighty-nine consecutive patients with brain metastases >2.0 cm who received SRS as primary treatment at Sant'Andrea Hospital, University of Rome Sapienza, Rome, Italy, were analyzed...
July 15, 2016: International Journal of Radiation Oncology, Biology, Physics
E Le Rhun, F Dhermain, G Vogin, N Reyns, P Metellus
INTRODUCTION: Radionecrosis (RN) represents the main complication of stereotactic radiotherapy (SRT) for brain metastases. It may be observed in up to 34% of cases at 24 months after treatment and associated with significant morbidity in 10-17%. AREAS COVERED: Our aim is to discuss the results of original studies on RN related to SRT for brain metastases. Expert commentary: Although the development of RN is unpredictable, larger volume of the lesion, prior whole brain irradiation, and higher dose of radiation represent the major risk factors...
August 2016: Expert Review of Neurotherapeutics
Christopher J Anker, Kenneth F Grossmann, Michael B Atkins, Gita Suneja, Ahmad A Tarhini, John M Kirkwood
BRAF kinase gene V600 point mutations drive approximately 40% to 50% of all melanomas, and BRAF inhibitors (BRAFi) have been found to significantly improve survival outcomes. Although radiation therapy (RT) provides effective symptom palliation, there is a lack of toxicity and efficacy data when RT is combined with BRAFi, including vemurafenib and dabrafenib. This literature review provides a detailed analysis of potential increased dermatologic, pulmonary, neurologic, hepatic, esophageal, and bowel toxicity from the combination of BRAFi and RT for melanoma patients described in 27 publications...
June 1, 2016: International Journal of Radiation Oncology, Biology, Physics
J Hernández Pinzón, D Mena, M Aguilar, F Biafore, G Recondo, M Bastianello
The use of (18)F-DOPA PET/CT with magnetic resonance imaging fusion and the use of visual methods and quantitative analysis helps to differentiate between changes post-radiosurgery vs. suspicion of disease progression in a patient with brain metastases from melanoma, thus facilitating taking early surgical action.
September 2016: Revista Española de Medicina Nuclear e Imagen Molecular
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