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https://www.readbyqxmd.com/read/28974415/hypofractionated-stereotactic-radiation-therapy-to-the-resection-bed-for-intracranial-metastases
#1
Audrey Keller, Mélanie Doré, Hélène Cebula, François Thillays, François Proust, Ioana Darié, Stéphane-André Martin, Gregory Delpon, François Lefebvre, Georges Noël, Delphine Antoni
PURPOSE: To retrospectively report the outcomes of a large multicenter cohort of patients treated with surgery and hypofractionated stereotactic radiation therapy (HFSRT) to the resection cavities of brain metastases (BMs). METHODS AND MATERIALS: Between March 2008 and February 2015, 181 patients with no prior whole-brain radiation therapy (WBRT) were treated by HFSRT to the surgical bed of BM at the dose of 33 Gy (3 × 11 Gy). The primary endpoint was local control...
August 19, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28973311/phase-i-trial-of-radiosurgery-dose-escalation-plus-bevacizumab-in-patients-with-recurrent-progressive-glioblastoma
#2
Mahmoud Abbassy, Symeon Missios, Gene H Barnett, Cathy Brewer, David M Peereboom, Manmeet Ahluwalia, Gennady Neyman, Samuel T Chao, John H Suh, Michael A Vogelbaum
BACKGROUND: The effectiveness of stereotactic radiosurgery (SRS) for recurrent glioblastoma (rGBM) remains uncertain. SRS has been associated with a high risk of radionecrosis in gliomas. OBJECTIVE: To determine the safety of dose escalation of single-fraction radiosurgery for rGBM in the setting of bevacizumab therapy. METHODS: We conducted a prospective trial to determine the safety and synergistic benefit of higher doses of SRS administered with bevacizumab for rGBM...
July 21, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28893524/-hippocampus-brainstem-and-brain-dose-volume-constraints-for-fractionated-3-d-radiotherapy-and-for-stereotactic-radiation-therapy-limits-and-perspectives
#3
REVIEW
M Gérard, R Jumeau, B Pichon, J Biau, E Blais, J Horion, G Noël
Cerebral radiation-induced toxicities after radiotherapy (RT) of brain tumors are frequent. The protection of organs at risk (OAR) is crucial, especially for brain tumors, to preserve cognition in cancer survivors. Dose constraints of cerebral OAR used in conventional RT, radiosurgery (SRS) and stereotactic radiotherapy (SRT) are debated. In fact, they are based on historical cohorts or calculated with old mathematical models. Values of α/β ratio of cerebral OAR are also controversial leading to misestimate the equivalent dose in 2Gy fractions or the biological equivalent dose, especially during hypofractionated RT...
October 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28879459/hypofractionated-radiotherapy-with-simultaneous-integrated-boost-sib-plus-temozolomide-in-good-prognosis-patients-with-glioblastoma-a-multicenter-phase-ii-study-by-the-brain-study-group-of-the-italian-association-of-radiation-oncology-airo
#4
Silvia Scoccianti, Marco Krengli, Livia Marrazzo, Stefano Maria Magrini, Beatrice Detti, Vincenzo Fusco, Luigi Pirtoli, Daniela Doino, Alba Fiorentino, Laura Masini, Daniela Greto, Michela Buglione, Giovanni Rubino, Federico Lonardi, Fernanda Migliaccio, Salvino Marzano, Riccardo Santoni, Umberto Ricardi, Lorenzo Livi
INTRODUCTION: A multicenter phase II study for assessing the efficacy and the toxicity of hypofractionated radiotherapy with SIB plus temozolomide in patients with glioblastoma was carried out by the Brain Study Group of the Italian Association of Radiation Oncology. METHODS: Twenty-four patients with newly diagnosed glioblastoma belonging to Recursive Partitioning Analysis classes III and IV were enrolled. The prescribed dose was 52.5 Gy in 15 fractions of 3.5 Gy and 67...
September 6, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28875373/differentiating-brain-radionecrosis-from-tumour-recurrence-a-role-for-contrast-enhanced-ultrasound
#5
Luca Mattei, Francesco Prada, Marcello Marchetti, Paola Gaviani, Francesco DiMeco
Differentiating radionecrosis from tumour recurrence is a major issue in neuro-oncology. Conventional imaging is far from being validated as an alternative to histological assessment. We report the case of a patient operated on for suspected recurrence of brain metastasis 9 months after cyberknife radiosurgery. While magnetic resonance imaging showed strong enhancement of the lesion, intraoperative contrast-enhanced ultrasonography (CEUS) surprisingly did not-different from what is expected for brain metastases...
September 5, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28870792/multicenter-phase-1-dose-escalation-study-of-hypofractionated-stereotactic-radiation-therapy-with-bevacizumab-for-recurrent-glioblastoma-and-anaplastic-astrocytoma
#6
Jennifer Clarke, Elizabeth Neil, Robert Terziev, Philip Gutin, Igor Barani, Thomas Kaley, Andrew B Lassman, Timothy A Chan, Josh Yamada, Lisa DeAngelis, Ase Ballangrud, Robert Young, Katherine S Panageas, Kathryn Beal, Antonio Omuro
PURPOSE: To establish the maximum tolerated dose of a 3-fraction hypofractionated stereotactic reirradiation schedule when delivered with concomitant bevacizumab to treat recurrent high-grade gliomas. METHODS AND MATERIALS: Patients with recurrent high-grade glioma with Karnofsky performance status ≥60, history of standard fractionated initial radiation, tumor volume at recurrence ≤40 cm(3), and absence of brainstem or corpus callosum involvement were eligible...
June 30, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28854994/brainstem-radionecrosis-in-a-patient-with-nasopharyngeal-carcinoma
#7
Theodora Afrantou, Konstantinos S Natsis, Aristomenis Angelou
No abstract text is available yet for this article.
August 31, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/28841798/re-irradiation-for-recurrent-glioblastoma-multiforme
#8
Christian Barney, Gaurav Shukla, Deepak Bhamidipati, Joshua D Palmer
As our understanding of normal brain tissue tolerance and radiation technology have improved, central nervous system (CNS) re-irradiation has garnered more attention; whereas, in the past there had been hesitancy due to late toxicity concerns, particularly radionecrosis (RN). There is minimal prospective data evaluating repeat radiation in recurrent gliomas. In this review, the rationale for and different approaches to re-irradiation will be discussed, and the biology and clinical impact of late CNS toxicity will be reviewed...
August 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28818094/radiotoxicity-in-robotic-radiosurgery-proposing-a-new-quality-index-for-optimizing-the-treatment-planning-of-brain-metastases
#9
Alexandra Hellerbach, Klaus Luyken, Mauritius Hoevels, Andreas Gierich, Daniel Rueß, Wolfgang W Baus, Martin Kocher, Maximilian I Ruge, Harald Treuer
BACKGROUND: As irradiated brain volume at 12 Gy (V12) is a predictor for radionecrosis, the purpose of the study was to develop a model for Cyberknife (CK) plans that is able to predict the lowest achievable V12 at a given tumor size and prescription dose (PD), and to suggest a new quality index regarding V12 for optimizing the treatment planning of brain metastases. METHOD: In our model V12 was approximated as a spherical shell around the tumor volume. The radial distance between tumor surface and the 12 Gy isodose line was calculated using an approximation of the mean dose gradient in that area...
August 17, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28721889/clinical-outcomes-of-large-brain-metastases-treated-with-neurosurgical-resection-and-intraoperative-cesium-131-brachytherapy-results-of-a-prospective-trial
#10
A Gabriella Wernicke, Cole B Hirschfeld, Andrew W Smith, Shoshana Taube, Menachem Z Yondorf, Bhupesh Parashar, Lucy Nedialkova, Fridon Kulidzhanov, Samuel Trichter, Albert Sabbas, Rohan Ramakrishna, Susan Pannullo, Theodore H Schwartz
PURPOSE: Studies on adjuvant stereotactic radiosurgery to the cavity of resected brain metastases have suggested that larger tumors (>2.0 cm) have greater rates of recurrence and radionecrosis (RN). The present study assessed the effect of permanent low-dose (131)Cs brachytherapy on local control and RN in patients treated for large brain metastases. METHODS AND MATERIALS: After institutional review board approval, 42 patients with 46 metastases ≥2.0 cm in preoperative diameter were accrued to a prospective trial from 2010 to 2015...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28656127/postoperative-fractionated-stereotactic-radiosurgery-to-the-tumor-bed-for-surgically-resected-brain-metastases
#11
Ryan K Cleary, Jessica Meshman, Michael Dewan, Liping Du, Anthony J Cmelak, Guozhen Luo, Manuel Morales-Paliza, Kyle Weaver, Reid Thompson, Lola B Chambless, Albert Attia
Introduction Stereotactic radiosurgery (SRS) is increasingly used as an alternative to whole brain radiotherapy (WBRT) following surgical resection of brain metastases. We analyzed the outcomes of postoperative frameless fractionated stereotactic radiosurgery (fSRS) cases for surgically resected brain metastases at our institution. Materials and Methods We performed a retrospective review of 85 patients who underwent fSRS to 87 resection beds from 2006 - 2014 with a median follow-up of 6.4 months. Clinically relevant outcomes were assessed with analysis to determine predictors of these outcomes...
May 26, 2017: Curēus
https://www.readbyqxmd.com/read/28599998/-pet-scan-and-nmr-spectroscopy-for-the-differential-diagnosis-between-brain-radiation-necrosis-and-tumour-recurrence-after-stereotactic-irradiation-of-brain-metastases-place-in-the-decision-tree
#12
I Menoux, G Noël, I Namer, D Antoni
PURPOSE: After stereotactic radiation therapy for brain metastases, one of the complications is radionecrosis. Differential diagnosis with tumour recurrence can be helped by different methods of imaging, although histology remains the gold standard. According to the treatment centres, practice diverges. The objective of this single-centre retrospective study was to define the power of MRI, PET scan and NMR spectroscopy to establish a decision tree. MATERIAL AND METHODS: This study included patients who underwent stereotactic radiation therapy for brain metastases, and required, during follow-up, both a PET scan and NMR spectroscopy in order to differentiate a radiation necrosis and tumour recurrence...
August 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28580203/single-fraction-stereotactic-radiosurgery-for-retreatment-of-skull-base-recurrent-head-and-neck-malignancies
#13
Rajal A Patel, Derrick Lock, Thomas Kim, Sandeep Samant, James P Chandler, Bharat B Mittal, Tim J Kruser
INTRODUCTION: Recurrent head and neck carcinomas are notoriously difficult to treat. Salvage surgery, brachytherapy, and repeat external beam radiotherapy have all been utilized, achieving modest local control at the expense of elevated toxicity. We performed a retrospective review to evaluate the efficacy of single fraction stereotactic radiosurgery (SRS) for the treatment of recurrent head and neck carcinomas. METHODS: Eighteen previously irradiated patients diagnosed with a locoregionally recurrent head and neck malignancy and treated with single fraction SRS from 2000 to 2016 were analyzed...
May 1, 2017: Curēus
https://www.readbyqxmd.com/read/28571888/management-of-the-airway-through-cervical-faringostoma-by-radionecrosis
#14
S Pardo, S Trabanco, M J Bartolomé, A Largo
No abstract text is available yet for this article.
May 29, 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/28551018/-risk-of-radionecrosis-after-hypofractionated-stereotactic-radiotherapy-targeting-the-postoperative-resection-cavity-of-brain-metastases
#15
MULTICENTER STUDY
A Keller, M Doré, D Antoni, I Menoux, F Thillays, J B Clavier, G Delpon, D Jarnet, C Bourrier, F Lefebvre, S Chibbaro, I Darié, F Proust, G Noël
PURPOSE: To investigate the factors that potentially lead to brain radionecrosis after hypofractionated stereotactic radiotherapy targeting the postoperative resection cavity of brain metastases. METHODS AND MATERIALS: A retrospective analysis conducted in two French centres, was performed in patients treated with trifractionated stereotactic radiotherapy (3×7.7Gy prescribed to the 70% isodose line) for resected brain metastases. Patients with previous whole-brain irradiation were excluded of the analysis...
August 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28543402/a-prediction-model-of-radiation-induced-necrosis-for-intracranial-radiosurgery-based-on-target-volume
#16
Bo Zhao, Ning Wen, Indrin J Chetty, Yimei Huang, Stephen L Brown, Karen C Snyder, Farzan Siddiqui, Benjamin Movsas, M Salim Siddiqui
PURPOSE: This study aims to extend the observation that the 12 Gy-radiosurgical-volume (V12Gy) correlates with the incidence of radiation necrosis in patients with intracranial tumors treated with radiosurgery by using target volume to predict V12Gy. V12Gy based on the target volume was used to predict the radiation necrosis probability (P) directly. Also investigated was the reduction in radiation necrosis rates (ΔP) as a result of optimizing the prescription isodose lines for linac-based SRS...
August 2017: Medical Physics
https://www.readbyqxmd.com/read/28499660/stereotactic-radiation-therapy-of-brain-metastases-from-colorectal-cancer-a-single-institution-cohort
#17
A Paix, D Antoni, R Adeduntan, G Noël
PURPOSE: The brain remains an uncommon site of colorectal cancer metastases. Due to the improvement of overall colorectal cancer patient survival, the incidence of brain metastases will likely rise. We report the efficacy and safety of hypofractionnated stereotactic radiation therapy and stereotactic radiosurgery, and its role in colorectal cancer brain metastasis management. METHODS AND MATERIAL: Between June 2010 and December 2014, fifteen consecutive patients received hypofractionnated stereotactic radiation therapy or stereotactic radiosurgery as first local therapy or following surgical removal for colorectal cancer brain metastases...
May 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28464742/functional-image-guided-dose-escalation-in-gliomas-using-of-state-of-the-art-photon-vs-proton-therapy
#18
Anne Ivalu Sander Holm, Jørgen Breede Baltzer Petersen, Ludvig Paul Muren, Klaus Seiersen, Per Borghammer, Slávka Lukacova
BACKGROUND: Recurrences of glioma are usually local, suggesting the need for higher tumor dose. We investigated the boundaries for dose escalation of an (18)F-fluoro-ethyl-tyrosine positron emission tomography defined target by intensity-modulated photon therapy (IMRT), volumetric modulated arc therapy (VMAT) and intensity-modulated proton therapy (IMPT). MATERIALS AND METHODS: Standard dose (60 Gy) and dose-escalated plans were calculated for seven patients using IMRT, VMAT and IMPT...
June 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28408096/local-treatment-of-a-pharyngocutaneous-fistula-secondary-to-osteoradionecrosis
#19
Olga González-Antolín
Radionecrosis is a late, and difficult to treat,complication of radiotherapy performed on head and neck tumours, and it is difficult to treat. This process causes significant damage, not only in the skin, but also in muscular, nervous, vascular, and bone structures. This, in turn, leads to airway and digestive tract involvement, as well as a functional loss and a cosmetic defect that usually requires reconstructive surgery. Therefore, this process is associated with a significant loss in the quality of life of patients and involves a long hospital stay for treatment, as well as the necessary support measures...
April 10, 2017: Enfermería Clínica
https://www.readbyqxmd.com/read/28382534/pseudoprogression-radionecrosis-inflammation-or-true-tumor-progression-challenges-associated-with-glioblastoma-response-assessment-in-an-evolving-therapeutic-landscape
#20
REVIEW
Benjamin M Ellingson, Caroline Chung, Whitney B Pope, Jerrold L Boxerman, Timothy J Kaufmann
The wide variety of treatment options that exist for glioblastoma, including surgery, ionizing radiation, anti-neoplastic chemotherapies, anti-angiogenic therapies, and active or passive immunotherapies, all may alter aspects of vascular permeability within the tumor and/or normal parenchyma. These alterations manifest as changes in the degree of contrast enhancement or T2-weighted signal hyperintensity on standard anatomic MRI scans, posing a potential challenge for accurate radiographic response assessment for identifying anti-tumor effects...
April 5, 2017: Journal of Neuro-oncology
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