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https://www.readbyqxmd.com/read/29771966/the-effect-of-chronic-progressive-dose-sodium-bicarbonate-ingestion-on-crossfit-like-performance-a-double-blind-randomized-cross-over-trial
#1
Krzysztof Durkalec-Michalski, Emilia E Zawieja, Tomasz Podgórski, Igor Łoniewski, Bogna E Zawieja, Marta Warzybok, Jan Jeszka
BACKGROUND: Sodium bicarbonate (SB) has been proposed as an ergogenic aid, as it improves high-intensity and resistance exercise performance. However, no studies have yet investigated SB application in CrossFit. This study examined the effects of chronic, progressive-dose SB ingestion on CrossFit-like performance and aerobic capacity. METHODS: In a randomized, double-blind, cross-over trial, 21 CrossFit-trained participants were randomly allocated to 2 groups and underwent 2 trials separated by a 14-day washout period...
2018: PloS One
https://www.readbyqxmd.com/read/29771807/administration-of-an-oral-hydration-solution-prevents-electrolyte-and-fluid-disturbances-and-reduces-readmissions-in-patients-with-a-diverting-ileostomy-after-colorectal-surgery-a-prospective-randomized-controlled-trial
#2
Athanasios Migdanis, Georgios Koukoulis, Ioannis Mamaloudis, Ioannis Baloyiannis, Ioannis Migdanis, Maria Kanaki, Eleni Malissiova, Georgios Tzovaras
BACKGROUND: Patients with a newly formed ileostomy often develop electrolyte abnormalities and dehydration. OBJECTIVE: The study assessed the prophylactic effect of an isotonic hydration solution on dehydration and electrolyte abnormalities in patients with a newly formed ileostomy. DESIGN: This was a prospective, randomized, controlled trial (NCT02036346). SETTINGS: The study was conducted at a single surgical unit of a public university hospital...
May 15, 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29770867/dietary-supplementation-with-an-amino-acid-blend-enhances-intestinal-function-in-piglets
#3
Dan Yi, Baocheng Li, Yongqing Hou, Lei Wang, Di Zhao, Hongbo Chen, Tao Wu, Ying Zhou, Binying Ding, Guoyao Wu
The traditionally classified nutritionally non-essential amino acids are now known to be insufficiently synthesized for maximal growth and optimal health in piglets. This study determined the effects of dietary supplementation with an amino acid blend (AAB; glutamate:glutamine:glycine:arginine:N-acetylcysteine = 5:2:2:1:0.5) on piglet growth performance and intestinal functions. Sixteen piglets (24-day-old) were randomly assigned to a corn and soybean meal-based diet supplemented with 0.99% alanine (isonitrogenous control) or 1% AAB...
May 16, 2018: Amino Acids
https://www.readbyqxmd.com/read/29765895/effect-of-smear-layer-deproteinization-on-bonding-of-self-etch-adhesives-to-dentin-a-systematic-review-and-meta-analysis
#4
Khaldoan H Alshaikh, Hamdi H H Hamama, Salah H Mahmoud
Objectives: The aim of this systematic review was to critically analyze previously published studies of the effects of dentin surface pretreatment with deproteinizing agents on the bonding of self-etch (SE) adhesives to dentin. Additionally, a meta-analysis was conducted to quantify the effects of the above-mentioned surface pretreatment methods on the bonding of SE adhesives to dentin. Materials and Methods: An electronic search was performed using the following databases: Scopus, PubMed and ScienceDirect...
May 2018: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/29764222/comparative-efficacy-of-once-weekly-semaglutide-and-sglt-2-inhibitors-in-type-2-diabetic-patients-inadequately-controlled-with-metformin-monotherapy-a-systematic-literature-review-and-network-meta-analysis
#5
Rohini Sharma, Lars Wilkinson, Hrvoje Vrazic, Evan Popoff, Sandra Lopes, Steve Kanters, Eric Druyts
OBJECTIVE: Treatment intensification with additional antidiabetic agents is recommended in type 2 diabetes (T2D) for patients inadequately controlled on metformin monotherapy. The present network meta-analysis (NMA) evaluated comparative efficacy and safety of once-weekly semaglutide and sodium-glucose co-transporter 2 inhibitors (SGLT-2is) in T2D patients inadequately controlled with metformin. METHODS: Randomized controlled trials with ≥20 weeks duration were searched in EMBASE, MEDLINE, and CENTRAL...
May 15, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29758155/six-month-evaluation-of-a-sodium-bicarbonate-containing-toothpaste-for-reduction-of-established-gingivitis-a-randomized-usa-based-clinical-trial
#6
Anto Jose, Jonathan Pratten, Mary-Lynn Bosma, Kimberly R Milleman, Jeffery L Milleman, Nan Wang
OBJECTIVES: Short-term use of sodium bicarbonate (NaHCO3)-containing toothpaste reduces plaque and improves clinical measures of gingivitis. To examine this over a longer period, we compared efficacy and tolerability of twice-daily brushing for 24 weeks with 67% or 0% NaHCO3-containing toothpastes in USA-based participants with moderate gingivitis (Clinicaltrials.gov:NCT02207400). METHODS: This was a six-month, randomized, examiner-blind, parallel-group, clinical trial...
March 2018: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/29757447/humic-acid-and-enzymes-inclusion-in-canola-based-diets-generate-different-responses-in-growth-performance-protein-utilization-dynamics-and-hemato-biochemical-parameters-in-broiler-chickens
#7
A R P Disetlhe, U Marume, V Mlambo
The current study was conducted to investigate the effect of a humic acid and enzymes on growth performance, protein utilization, and blood parameters in broilers fed canola-based diets. Canola meal (CM) is characterized as low protein compared to soybean meal. Two-hundred-twenty broiler chickens were randomly allotted to the following 5 dietary treatments: 1. Control (commercial broiler diet); 2. CM (17.5% canola meal inclusion); 3. CMEnz (CM + 0.3 g/kg enzymes [Axtra XAP]); 4. CMPh (CM + 1.5% potassium humate, PH) and 5...
May 10, 2018: Poultry Science
https://www.readbyqxmd.com/read/29753693/oral-administration-of-5-aminolevulinic-acid-induces-heme-oxygenase-1-expression-in-peripheral-blood-mononuclear-cells-of-healthy-human-subjects-in-combination-with-ferrous-iron
#8
Hidenori Ito, Yoshiaki Nishio, Takeshi Hara, Hidemitsu Sugihara, Tohru Tanaka, Xiao-Kang Li
Heme oxygenase-1 (HO-1) is a major anti-inflammatory enzyme and a key regulator that induces immune tolerance through affecting the differentiation of dendritic cells. The aim of this study is to determine whether the combination of 5-aminolevulinic acid (ALA) and iron induces HO-1 expression in healthy human peripheral blood mononuclear cells (PBMC). The study was an open labeled, non-randomized, non-placebo-controlled trial using healthy male adults and consisted of three parts. Study A aimed to find the peak HO-1 expression at 0, 1, 2, 3, 4, 6, 8, 12, 16, and 24h after administration...
May 10, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29752695/sodium-tanshinone-ii-a-sulfonate-for-coronary-heart-disease-a-systematic-review-of-randomized-controlled-trials
#9
Mei-Li Yu, Si-Ming Li, Xiang Gao, Jin-Gen Li, Hao Xu, Ke-Ji Chen
OBJECTIVE: To assess whether an adjunctive therapy of Sodium Tanshinone II A Sulfonate Injection (STS) is effective and safe in improving clinical outcomes in patients with coronary heart disease (CHD). METHODS: literature search was conducted through PubMed, the Cochrane Library, Knowledge Infrastructure Databases (CNKI), Chinese Biomedical Literature Database (SinoMed), Chinese Science and Technology Periodical Database (VIP) and Wanfang Database up to August 2017...
May 11, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29746282/comparing-the-effects-of-atorvastatin-with-sodium-valproate-divalproex-on-frequency-and-intensity-of-frequent-migraine-headaches-a-double-blind-randomized-controlled-study
#10
Omid Hesami, Mohammad Sistanizad, Elnaz Asadollahzade, Mohammad-Sadegh Johari, Nahid Beladi-Moghadam, Homa Mazhabdar-Ghashghai
OBJECTIVES: To evaluate the prophylactic effects of atorvastatin on frequency, intensity, and duration of migraine attacks compared with sodium valproate. METHODS: In this randomized, double-blind, single-center controlled trial, patients with 6 to 15 migraine attacks per month, which were candidates of preventive treatment, were recruited. The patients were randomly allocated into 2 groups. The first group (A) received atorvastatin 40 mg daily, and the second group (B) received sodium valproate 500 mg daily...
May 2018: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/29740015/effects-of-5-aminolevulinic-acid-supplementation-on-home-based-walking-training-achievement-in-middle-aged-depressive-women-randomized-double-blind-crossover-pilot-study
#11
Hiroshi Suzuki, Shizue Masuki, Akiyo Morikawa, Yu Ogawa, Yoshi-Ichiro Kamijo, Kiwamu Takahashi, Motowo Nakajima, Hiroshi Nose
Depressive patients often experience difficulty in performing exercise due to physical and psychological barriers. We examined the effects of 5-aminolevulinic acid (ALA) with sodium ferrous citrate (SFC) supplementation during home-based walking training in middle-aged depressive women. Nine outpatients [53 ± 8 (SD) yr] with major depressive disorder participated in the pilot study with randomized, placebo-controlled, double-blind crossover design. They underwent two trials for 7 days, each performing interval walking training (IWT) with ALA + SFC (ALA + SFC) or placebo supplement intake (PLC) intermittently with >a 10-day washout period...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29736490/in-office-treatments-for-dentin-hypersensitivity-a-randomized-split-mouth-clinical-trial
#12
Deise Osmari, Sara Fraga, Ana Carolina de Oliveira Ferreira, Carlos de Paula Eduardo, Marcela Marquezan, Bruno Lopes da Silveira
PURPOSE: To assess the effectiveness of four in-office therapies used for the treatment of dentin hypersensitiviy (DH) after one single application. MATERIALS AND METHODS: A randomised, controlled, split-mouth clinical trial was designed to evaluate the following treatments: 5% sodium fluoride varnish (positive control); 3% potassium oxalate; two-step self-etching adhesive; high power diode laser. Nineteen patients were selected and one tooth per quadrant was included in the study...
2018: Oral Health & Preventive Dentistry
https://www.readbyqxmd.com/read/29732932/perceived-barriers-to-adherence-to-hemodialysis-dietary-recommendations
#13
Maya N Clark-Cutaia, Mary Ann Sevick, Jennifer Thurheimer-Cacciotti, Leslie A Hoffman, Linda Snetselaar, Lora E Burke, Susan L Zickmund
Barriers to following dietary recommendations have been described; however, they remain poorly understood. The purpose of this qualitative study was to explore perceived barriers to adherence to dietary recommendations in a diverse hemodialysis patient population. Participants were eligible to participate in a semi-structured qualitative telephone interview prior to randomization for an ongoing clinical trial to evaluate the efficacy of an intervention designed to reduce dietary sodium intake. Interviews were digitally recorded, transcribed verbatim and coded using an iterative qualitative process...
May 1, 2018: Clinical Nursing Research
https://www.readbyqxmd.com/read/29729189/ad-libitum-mediterranean-and-low-fat-diets-both-significantly-reduce-hepatic-steatosis-a-randomized-controlled-trial
#14
Catherine Properzi, Therese A O'Sullivan, Jill L Sherriff, Helena L Ching, Garry P Jeffrey, Rachel F Buckley, Jonathan Tibballs, Gerry C MacQuillan, George Garas, Leon A Adams
Although diet induced weight loss is first-line treatment for patients with non-alcoholic fatty liver disease (NAFLD), long-term maintenance is difficult. The optimal diet for either improvement in NAFLD or associated cardio-metabolic risk factors regardless of weight loss, is unknown. We examined the effect of two ad libitum isocaloric diets [Mediterranean (MD) or Low Fat (LF)] on hepatic steatosis and cardio-metabolic risk factors. Subjects with NAFLD were randomized to a 12-week blinded dietary intervention (MD vs LF)...
May 5, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29722800/effects-of-orthodontic-treatment-and-different-fluoride-regimens-on-numbers-of-cariogenic-bacteria-and-caries-risk-a-randomized-controlled-trial
#15
Hanna Enerbäck, Marie Möller, Cathrine Nylén, Cecilia Ödman Bresin, Ingrid Östman Ros, Anna Westerlund
Background: Caries is an undesirable side-effect of treatment with fixed orthodontic appliances. Therefore, it is crucial to understand how orthodontic treatment and different fluoride regimens affect caries risk and individual risk factors. Objective: To evaluate the effects of orthodontic treatment and different fluoride regimens on caries risk and caries risk factors, including cariogenic bacteria. Trial design: Three-armed, parallel group, randomized, controlled trial...
May 2, 2018: European Journal of Orthodontics
https://www.readbyqxmd.com/read/29718689/comparative-effects-of-different-dietary-approaches-on-blood-pressure-in-hypertensive-and-pre-hypertensive-patients-a-systematic-review-and-network-meta-analysis
#16
Lukas Schwingshackl, Anna Chaimani, Carolina Schwedhelm, Estefania Toledo, Marina Pünsch, Georg Hoffmann, Heiner Boeing
BACKGROUND: Pairwise meta-analyses have shown beneficial effects of individual dietary approaches on blood pressure but their comparative effects have not been established. OBJECTIVE: Therefore we performed a systematic review of different dietary intervention trials and estimated the aggregate blood pressure effects through network meta-analysis including hypertensive and pre-hypertensive patients. DESIGN: PubMed, Cochrane CENTRAL, and Google Scholar were searched until June 2017...
May 2, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29713851/assessment-of-complementary-treatment-with-yiqi-fumai-lyophilized-injection-on-acute-decompensated-ischemic-heart-failure-act-adihf-rationale-and-design-of-a-multicenter-randomized-controlled-trial
#17
Xianliang Wang, Zhiqiang Zhao, Yazhu Hou, E Tang, Guoyuan Zhao, Shuai Wang, Yingfei Bi, Chengliang Zhong, Ming Ren, Junhua Zhang, Jingyuan Mao, Boli Zhang
BACKGROUND: Heart failure (HF) is the end stage of many heart diseases, and ischemic heart disease (IHD) is the primary cause. Yiqi Fumai lyophilized injection, a contemporary Chinese medicine preparation, widely used in the treatment of IHF patients, shows clinical efficacy on improving symptoms and cardiac function, but the quality of the current literature does not address multiple important issues. This article describes a protocol for assessment of complementary treatment with Yiqi Fumai lyophilized injection in acute decompensated IHD...
April 30, 2018: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/29710221/what-surgeons-should-know-about-non-vitamin-k-oral-anticoagulants-a-review
#18
Atul Verma, Andrew C T Ha, James T Rutka, Subodh Verma
Importance: Non-vitamin K oral anticoagulants (NOACs) are increasingly prescribed for patients to treat or prevent arterial or venous thromboembolism. The following 4 NOAC agents are approved by the US Food and Drug Administration for clinical use: dabigatran etexilate, apixaban, edoxaban tosylate, and rivaroxaban. A good understanding of these agents' pharmacologic properties is important for surgeons given their marked differences compared with warfarin sodium. This review highlights key practical issues surrounding the use of NOACs in the perioperative setting...
April 18, 2018: JAMA Surgery
https://www.readbyqxmd.com/read/29699723/delayed-increase-of-thrombocyte-levels-after-a-single-sub-anesthetic-dose-of-ketamine-a-randomized-trial
#19
Lejla Colic, Marie Woelfer, Merima Colic, Anna Linda Leutritz, Thomas Liebe, Luisa Fensky, Zumrut Duygu Sen, Meng Li, Juliane Hoffmann, Moritz A Kretzschmar, Berend Isermann, Martin Walter
Recently, ketamine has been investigated as a potential antidepressant option for treatment resistant depression. Unlike traditional drugs, it yields immediate effects, most likely via increased glutamatergic transmission and synaptic plasticity. However, ketamine administration in humans is systemic and its long-term impact on blood parameters has not yet been described in clinical studies. Here we investigated potential sustained effects of ketamine administration (0.5 mg/kg ketamine racemate) on hematological and biochemical values in plasma and serum in a randomized double-blinded study...
April 23, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29696037/pharmacological-treatment-in-diabetes-mellitus-type-1-insulin-and-what-else
#20
REVIEW
Ewa Otto-Buczkowska, Natalia Jainta
The basis of treatment in autoimmune diabetes is insulin therapy; however, many clinical cases have proven that this method does not solve all problems. Trials of causal treatment including blocking the autoimmune processes and insulin-producing cells transplants were carried out. Those methods require more research to be concerned as efficient and safe ways of treatment in type 1 diabetes. The use of non-insulin adjunct treatment is a new trend. It has been successfully used in laboratories as well as clinical trials...
January 2018: International Journal of Endocrinology and Metabolism
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