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https://www.readbyqxmd.com/read/28642564/remineralisation-and-arresting-caries-in-children-with-topical-fluorides
#1
Neeraj Gugnani, Shalini Gugnani
Data sourcesThe Cochrane Library, PubMed, Embase and the ISI Web of Science.Study selectionEnglish language clinical trials in children with outcome measures including the remineralisation or arresting effect of caries by professional fluoride treatment were considered.Data extraction and synthesisTwo reviewers screened the studies and assessed risk of bias. Random effects meta-analysis was conducted.ResultsSeventeen studies were included, ten focused on remineralisation, seven on arresting carious lesions...
June 23, 2017: Evidence-based Dentistry
https://www.readbyqxmd.com/read/28637887/mitigating-cardiovascular-risk-in-type-2-diabetes-with-antidiabetes-drugs-a-review-of-principal-cardiovascular-outcome-results-of-empa-reg-outcome-leader-and-sustain-6-trials
#2
Sanjay Kaul
The U.S. Food and Drug Administration (FDA) issued a diabetes guidance in 2008 mandating that all new antidiabetes drugs rule out excess cardiovascular (CV) risk, defined as an upper bound of the two-sided 95% CI for major adverse CV events (MACE) of less than 1.80 preapproval and 1.30 postapproval. Over 25 large, prospective, randomized, controlled clinical trials involving nearly 195,000 subjects thus far have been completed or are ongoing in accordance with this guidance. The results of seven trials have been presented so far-three with dipeptidyl peptidase 4 inhibitors, one with a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and three with glucagon-like peptide 1 receptor agonists (GLP-1 RA)...
July 2017: Diabetes Care
https://www.readbyqxmd.com/read/28633650/effects-of-tolvaptan-in-patients-with-acute-heart-failure-a-systematic-review-and-meta-analysis
#3
Chunbin Wang, Bo Xiong, Lin Cai
BACKGROUND: Acute heart failure, which requires urgent evaluation and treatment, is a leading cause for admission to the emergency department. The aim of this meta-analysis was to evaluate the effects of tolvaptan on acute heart failure and compare them with the effects of conventional therapy or placebo. METHODS: The electronic databases PubMed, EMBASE, and the Cochrane Controlled Trial registry were searched from their starting dates to October 24, 2016. Two authors independently read the trials and extracted related information from the included studies...
June 20, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28631933/a-salt-reduction-smartphone-app-supports-lower-salt-food-purchases-for-people-with-cardiovascular-disease-findings-from-the-saltswitch-randomised-controlled-trial
#4
Helen Eyles, Rebecca McLean, Bruce Neal, Yannan Jiang, Robert N Doughty, Rachael McLean, Cliona Ni Mhurchu
Background SaltSwitch is an innovative smartphone application (app) that enables shoppers to scan the barcode of a packaged food and receive an immediate, interpretive, traffic light nutrition label on the screen, along with suggestions for lower salt alternatives. Our aim was to determine the effectiveness of SaltSwitch to support people with cardiovascular disease to make lower salt food choices. Design Six-week, two-arm, parallel, randomised controlled trial in Auckland, New Zealand (2 weeks baseline and 4 weeks intervention)...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28622115/ppar%C3%AE-2-c1431t-polymorphism-interacts-with-the-antiobesogenic-effects-of-kochujang-a-korean-fermented-soybean-based-red-pepper-paste-in-overweight-obese-subjects-a-12-week-double-blind-randomized-clinical-trial
#5
Yunkyoung Lee, Youn-Soo Cha, Yongsoon Park, Myoungsook Lee
Kochujang, a Korean fermented soybean-based red pepper paste, has been reported to have beneficial health effects. The aim of this study was to examine the antiobesity effects of Kochujang as a supplement in overweight/obese subjects according polymorphisms in the obesity-linked gene, peroxisome proliferator activator receptor γ (PPARγ2). Sixty overweight/obese subjects, who had body mass indexes (BMI, kg/m(2)) ≥23 or waist/hip ratios (WHR) ≥0.90 for males or ≥0.85 for females, were randomly assigned to either taking 32 g/day of placebo or Kochujang for 12 weeks...
June 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28610932/automatic-environmental-disinfection-with-hydrogen-peroxide-and-ion-silver-versus-manual-environmental-disinfection-with-sodium-hypochlorite-a-multicenter-randomized-before-and-after-trial
#6
D Mosci, G W Marmo, L Sciolino, C Zaccaro, R Antonellini, L Accogli, T Lazzarotto, M Mongardi, M P Landini
AIMS: 1. Compare the effectiveness of an automated disinfection system with hydrogen peroxide <8% and silver ion versus a manual method with 0.5% sodium hypochlorite solution to evaluate the reduction of microbial mesophilic contamination and Clostridium difficile (CD) presence; 2. Evaluate the organizational impact of these two technologies in terms of time required for the process. METHODS: A randomized multicenter trial performed in four public and private health facilities in the Emilia-Romagna Region, in different wards including medicine, orthopaedics, long-term care, recovery and functional rehabilitation, which were previously occupied by patients with Clostridium difficile Infection (CDI)...
June 10, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28606267/-comparison-of-two-kinds-of-artificial-tears-on-the-dry-eye-after-phacoemulsification
#7
R You, J Wang, Y Han, L J Liu, W Y Wang
Objective: To compare the curative effect of two different artificial tears on dry eye after phacoemulsification. Methods: Prospective randomized controlled clinical trial. From March to June in 2012, 102 patients (102 eyes) with age-related cataract were treated with phacoemulsification at Beijing Tongren Hospital, Capital University of Medical Sciences, and these eyes were randomly divided into blank group (group A ) 32 cases, treatment group 1 (group B) 35 cases and treatment group 2 (group C) 35 cases. Group A was treated with conventional antibiotics...
June 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28605608/canagliflozin-and-cardiovascular-and-renal-events-in-type-2-diabetes
#8
Bruce Neal, Vlado Perkovic, Kenneth W Mahaffey, Dick de Zeeuw, Greg Fulcher, Ngozi Erondu, Wayne Shaw, Gordon Law, Mehul Desai, David R Matthews
Background Canagliflozin is a sodium-glucose cotransporter 2 inhibitor that reduces glycemia as well as blood pressure, body weight, and albuminuria in people with diabetes. We report the effects of treatment with canagliflozin on cardiovascular, renal, and safety outcomes. Methods The CANVAS Program integrated data from two trials involving a total of 10,142 participants with type 2 diabetes and high cardiovascular risk. Participants in each trial were randomly assigned to receive canagliflozin or placebo and were followed for a mean of 188...
June 12, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28597117/oral-dexamethasone-decreases-postoperative-pain-swelling-and-trismus-more-than-diclofenac-following-third-molar-removal-a-randomized-controlled-clinical-trial
#9
Carlos Alysson Aragão Lima, Vinícius Tatsumoto Favarini, Alexandre Machado Torres, Rogério Almeida da Silva, Fábio Ricardo Loureiro Sato
PURPOSE: The aim of this study was to compare the anti-inflammatory potential of two pharmacotherapy protocols based on the parameters of pain, trismus, and swelling, after extraction of third molars. METHODS: Thirty patients selected with symmetrical impaction of third molars were submitted to surgical procedures in both sides in different times. For one group, dexamethasone was used for 3 days, and for another group diclofenac sodium was also used for the same period...
June 8, 2017: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28594482/non-severe-hypoglycemia-risk-difference-between-sulfonylurea-and-sodium-glucose-cotransporter-2-inhibitors-sglt2-i-as-an-add-on-to-metformin-in-randomized-controlled-trials
#10
Pendar Farahani
BACKGROUND: Non-severe hypoglycemia reduces well-being, lowers quality of life, reduces productivity and increases treatment costs. The non-severe hypoglycemia rate, attributable to sulfonylurea (SU) utilization compared with newer classes such as SGLT2-I, could be of clinical significance. OBJECTIVES: To explore the non-severe hypoglycemia risk difference (RD) for SU use compared with SGLT2-I in randomized controlled trials (RCTs) as an add on to metformin. METHODS: A search was conducted for RCTs of SGLT2-I...
May 23, 2017: Journal of Population Therapeutics and Clinical Pharmacology
https://www.readbyqxmd.com/read/28593470/effect-of-selenium-from-selenium-enriched-kale-sprout-versus-other-selenium-sources-on-productivity-and-selenium-concentrations-in-egg-and-tissue-of-laying-hens
#11
Anut Chantiratikul, Orawan Chinrasri, Piyanete Chantiratikul
A 6-week trial was conducted to compare the effect of selenium (Se) from hydroponically produced Se-enriched kale sprout (HPSeKS), sodium selenite (SS), and Se-enriched yeast (SeY) in laying hens. A total of 144 40-week-old hens were randomly divided into four groups, according to a completely randomized design. Each group consisted of four replicates with nine hens per replicate. The dietary treatments were T1 (basal diet) and T2, T3, and T4 (basal diets supplemented with 0.30 mg Se/kg from SS, SeY, and HPSeKS, respectively)...
June 7, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28589039/gum-arabic-reduces-c-reactive-protein-in-chronic-kidney-disease-patients-without-affecting-urea-or-indoxyl-sulfate-levels
#12
Sarra Elamin, Mariam J Alkhawaja, Amina Y Bukhamsin, Mohamed A S Idris, Muntasir M Abdelrahman, Nasrulla K Abutaleb, Abdulrahman A Housawi
INTRODUCTION: Gum Arabic (GA) is a complex polysaccharide with proven prebiotic properties and potentially beneficial systemic effects. METHODS: We randomly allocated 36 chronic kidney disease (CKD) patients to receive 10, 20, or 40 grams daily of GA for four weeks and studied the systemic effects of this intervention. RESULTS: Thirty participants completed the study with baseline glomerular filtration rate 29.1 ± 9.9 mL/min/1.7 m(2)...
2017: International Journal of Nephrology
https://www.readbyqxmd.com/read/28588220/effects-of-sglt2-inhibitors-on-utis-and-genital-infections-in-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis
#13
Jiali Liu, Ling Li, Sheyu Li, Pengli Jia, Ke Deng, Wenwen Chen, Xin Sun
Previous trial evidence suggested potential risk of serious urinary tract infections (UTIs) and genital infections in type 2 diabetes patients using sodium glucose co-transporter-2 inhibitors (SGLT2) inhibitors. We conducted a systematic review and meta-analysis to assess the effects of SGLT2 inhibitors on UTIs and genital infections in patients with type 2 diabetes. In total, 77 RCTs involving 50,820 participants were eligible. The meta-analyses of randomized controlled trials (RCTs) showed no significant difference in UTIs between SGLT2 inhibitors versus control (2,526/29,086 vs...
June 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28584540/evaluation-and-comparison-of-efficacy-of-three-desensitizing-dentifrices-on-dentinal-hypersensitivity-and-salivary-biochemical-characteristics-a-randomized-controlled-trial
#14
Deepthi Athuluru, Chandrasekhara Reddy, K M Sudhir, Krishna Kumar, Sreenivasulu Gomasani, Sreenivas Nagarakanti
BACKGROUND: This study aimed to evaluate and compare the efficacy of three desensitizing dentifrices on dentinal hypersensitivity (DH) and salivary biochemical characteristics. MATERIALS AND METHODS: A randomized, parallel arm, triple-blinded, clinical trial was conducted over a period of 12 weeks, with a total of three visits: baseline, 6 weeks, and 12 weeks. Calcium sodium phosphosilicate, potassium nitrate and amine fluoride dentifrices were compared. A total of 68 subjects who satisfied the inclusion criteria were included and randomly divided into four groups...
March 2017: Dental Research Journal
https://www.readbyqxmd.com/read/28584432/the-effect-of-high-dose-parenteral-sodium-selenite-in-critically-ill-patients-following-sepsis-a-clinical-and-mechanistic-study
#15
Legese Chelkeba, Arezoo Ahmadi, Mohammad Abdollahi, Atabak Najafi, Mohammad Hosein Ghadimi, Reza Mosaed, Mojtaba Mojtahedzadeh
INTRODUCTION: Severe sepsis and septic shock is characterized by inflammation and oxidative stress. Selenium levels have been reported to be low due to loss or increased requirements during severe sepsis and septic shock. We investigated the effect of high-dose parenteral selenium administration in septic patients. METHODS: A prospective, randomized control clinical trial was performed in septic patients. After randomization, patients in selenium group received high-dose parenteral sodium selenite (2 mg intravenous [IV] bolus followed by 1...
May 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28577665/rationale-design-and-baseline-characteristics-of-the-salt-substitute-and-stroke-study-ssass-a-large-scale-cluster-randomized-controlled-trial
#16
Bruce Neal, Maoyi Tian, Nicole Li, Paul Elliott, Lijing L Yan, Darwin R Labarthe, Liping Huang, Xuejun Yin, Zhixin Hao, Sandrine Stepien, Jingpu Shi, Xiangxian Feng, Jianxin Zhang, Yuhong Zhang, Ruijuan Zhang, Yangfeng Wu
Lowering sodium intake with a reduced-sodium, added potassium salt substitute has been proved to lower blood pressure levels. Whether the same strategy will also reduce the risks of vascular outcomes is uncertain and controversial. The SSaSS has been designed to test whether sodium reduction achieved with a salt substitute can reduce the risk of vascular disease. The study is a large-scale, open, cluster-randomized controlled trial done in 600 villages across 5 provinces in China. Participants have either a history of stroke or an elevated risk of stroke based on age and blood pressure level at entry...
June 2017: American Heart Journal
https://www.readbyqxmd.com/read/28570250/effect-of-negative-pressure-wound-therapy-with-instillation-on-bioburden-in-chronically-infected-wounds
#17
Chun Yang, Selena G Goss, Sean Alcantara, Greg Schultz, John C Lantis Ii
INTRODUCTION: Standard negative pressure wound therapy (NPWT) has been shown to help close wounds despite increasing planktonic bioburden. Both planktonic and biofilm critical colonization are associated with delayed wound healing; therefore, reducing microbial colonization is thought to aid wound healing. The use of NPWT with topical antimicrobial irrigation solution has previously shown reduction in quantitative planktonic bioburden when combined with sharp debridement in chronic wounds...
May 25, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28566523/gastric-and-postgastric-processing-of-13-c-markers-renders-the-13-c-breath-test-an-inappropriate-measurement-method-for-the-gastric-emptying-of-lipid-emulsions-in-healthy-adults
#18
Helen L Parker, Dian Liu, Jelena Curcic, Marc-Olivier Ebert, Werner Schwizer, Michael Fried, Andreas Steingoetter
Background: Breath tests (BTs) present an alternative gastric-emptying (GE) measure. However, their efficacy in the measurement of the GE rate of lipid emulsions (LEs) is unknown.Objective: The objective of this work was to investigate the validity of (13)C BTs as a measure of fat GE rate in LEs.Methods: The lipophilic (13)C octanoate (OCC) BT marker was investigated for fat GE with the hydrophilic (13)C sodium acetate (ACC) and the triglyceride (13)C trioctanoin (TCC) markers as comparators. Data from 2 randomized studies were combined [50 healthy participants; 25 men, mean ± SD age: 23 ± 2...
May 31, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28566266/the-development-of-a-web-based-program-to-reduce-dietary-salt-intake-in-schoolchildren-study-protocol
#19
Carley Ann Grimes, Alison Booth, Durreajam Khokhar, Madeline West, Claire Margerison, Karen Campbell, Caryl Nowson
BACKGROUND: Salt intake of schoolchildren in the Australian state of Victoria is high. To protect future cardiovascular health, interventions that seek to reduce the amount of salt in children's diets are required. OBJECTIVE: We sought to develop and pilot test a Web-based program (Digital Education to Limit Salt Intake in the Home [DELISH]) that aims to reduce dietary salt intake among schoolchildren and to improve child and parent knowledge, attitudes, and behaviors related to salt intake...
May 31, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28560121/comparison-of-different-analgesia-drug-regimens-for-pain-control-during-extracorporeal-shock-wave-lithotripsy-for-renal-stones-a-randomized-control-study
#20
Muhammad Waqas, Amna Butt, Mohammad Ayaz Khan, Ijaz Khan, Imad-Ud-Din Saqib, Tariq Hussain, Saeed Akhter
INTRODUCTION: With the increased use of extracorporeal shock wave lithotripsy (ESWL), the management of urolithiasis has become much convenient for the patients and the health care professionals alike. However, associated with the procedure is the common complaint of pain. No agreed upon pain management strategy has yet been developed for the procedure. We compared the effect of different analgesia drug regiments for pain control. METHODOLOGY: A randomised controlled trial was carried out in Shifa International Hospital from between July 2015 to January 2016...
April 26, 2017: Curēus
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