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https://www.readbyqxmd.com/read/28917493/usefulness-of-myocardial-annular-velocity-change-during-mental-stress-to-predict-cardiovascular-outcome-in-patients-with-coronary-artery-disease-from-the-responses-of-mental-stress-induced-myocardial-ischemia-to-escitalopram-treatment-trial
#1
Fawaz Alenezi, Beverly H Brummett, Stephen H Boyle, Zainab Samad, Michael A Babyak, Nabil Alzaeim, Jennifer Wilson, Minna M D Romano, Julia L Sun, Mads Ersboll, Christopher M O'Connor, Eric J Velazquez, Wei Jiang
Mental stress-induced myocardial ischemia is common and a prognostic factor of adverse cardiovascular outcomes in patients with coronary artery disease (CAD). The present study aimed at examining associations between mental stress-induced myocardial annular velocity (MAV) and cardiovascular outcome in patients with CAD. MAV, specifically, diastolic early (e'), diastolic late (a'), and systolic (s') velocities were obtained at rest and during mental stress testing in 224 patients with clinically stable CAD. Using Cox regression models, age, sex, and baseline-adjusted mental stress-induced MAV measures were examined as predictors of a priori defined composite event term that comprised all-cause mortality and/or nonfatal cardiovascular events, resulting in an unplanned hospitalization (major adverse cardiovascular events [MACE])...
July 29, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28910072/mapping-the-binding-site-for-escitalopram-and-paroxetine-in-the-human-serotonin-transporter-using-genetically-encoded-photocrosslinkers
#2
Hafsteinn Rannversson, Jacob Andersen, Benny Bang-Andersen, Kristian Strømgaard
In spite of the important role of the human serotonin transporter (hSERT) in depression treatment, the molecular details of how antidepressant drugs bind are still not completely understood, in particular those related to potential high- and low-affinity binding sites in hSERT. Here, we utilize amber codon suppression in hSERT to encode the photocrosslinking unnatural amino acid p-azido-L-phenylalanine into the suggested high- and low-affinity binding sites. We then employ UV-induced crosslinking with azF to map the binding site of escitalopram and paroxetine, two prototypical selective serotonin reuptake inhibitors (SSRIs)...
September 14, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28904397/study-of-the-link-between-dopamine-transporter-gene-polymorphisms-and-response-to-paroxetin-and-escitalopram-in-patients-with-lifelong-premature-ejaculation
#3
T K Eltonsi, T M Tawfik, L A Rashed, S F GamalEl Din, M A Mahmoud
We evaluated the role of dopamine (DA) transporter gene polymorphism in lifelong premature ejaculation (LPE) and its role in determining the response to paroxetine and escitalopram. Eighty consecutive patients and controls were recruited. Sixty of them suffered from LPE. They were divided into two equal groups. One group received paroxetine 20 mg daily for 3 months and the other one received ecistalopram 20 mg daily for 3 months. Their wives were instructed to measure the intra-vaginal ejaculation latency time using stopwatch...
September 14, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/28903098/cognitive-behavioral-analysis-system-of-psychotherapy-versus-escitalopram-in-patients-with-chronic-depression-results-from-a-naturalistic-long-term-follow-up
#4
Paul Bausch, Thomas Fangmeier, Elisabeth Schramm, Ingo Zobel, Sarah Drost, Knut Schnell, Henrik Walter, Mathias Berger, Dieter Schoepf, Claus Normann
No abstract text is available yet for this article.
September 14, 2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/28899417/serotonin-augmentation-therapy-by-escitalopram-has-minimal-effects-on-amyloid-%C3%AE-levels-in-early-stage-alzheimer-s-like-disease-in-mice
#5
Christian Ulrich von Linstow, Jonas Waider, Manuela Grebing, Athanasios Metaxas, Klaus Peter Lesch, Bente Finsen
BACKGROUND: Dysfunction of the serotonergic (5-HTergic) system has been implicated in the cognitive and behavioural symptoms of Alzheimer's disease (AD). Accumulation of toxic amyloid-β (Aβ) species is a hallmark of AD and an instigator of pathology. Serotonin (5-HT) augmentation therapy by treatment with selective serotonin reuptake inhibitors (SSRIs) in patients with AD has had mixed success in improving cognitive function, whereas SSRI administration to mice with AD-like disease has been shown to reduce Aβ pathology...
September 12, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28895028/prevalence-of-qt-interval-prolonging-drug-drug-interactions-qt-ddis-in-psychiatry-wards-of-tertiary-care-hospitals-in-pakistan-a-multicenter-cross-sectional-study
#6
Qasim Khan, Mohammad Ismail, Iqbal Haider, Fahadullah Khan
Background QT prolongation and associated arrhythmias, torsades de pointes (TdP), are considerable negative outcomes of many antipsychotic and antidepressant agents frequently used by psychiatric patients. Objective To identify the prevalence, levels, and predictors of QT prolonging drug-drug interactions (QT-DDIs), and AZCERT (Arizona Center for Education and Research on Therapeutics) classification of drugs involved in QT-DDIs. Setting Psychiatry wards of three major tertiary care hospitals of Khyber-Pakhtunkhwa, Pakistan...
September 12, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28875616/prescription-pattern-of-antidepressants-for-children-and-adolescents-in-korea-based-on-nationwide-data
#7
Myong Wuk Chon, Jungsun Lee, Seockhoon Chung, Yangsik Kim, Hyo Won Kim
Antidepressant prescription for youths has recently been on the increase. There is a growing concern over the increasing off-label usage of antidepressants. Current data on off-label antidepressant usage vary across countries and healthcare systems. Therefore, we examined the extent and pattern of antidepressant prescription for Korean children and adolescents using population-based data. Our data was retrieved from the Korean National Health Insurance Service National Sample Cohort of the year 2013. Among 0...
October 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28866072/changes-in-the-cannabinoids-receptors-in-rats-following-treatment-with-antidepressants
#8
Irena Smaga, Magdalena Zaniewska, Dawid Gawliński, Agata Faron-Górecka, Przemysław Szafrański, Marek Cegła, Małgorzata Filip
The endocannabinoid (eCB) system plays a significant role in the pathophysiology of depression. The potential participation of this system in the mechanism of action of antidepressants has been highlighted in recent years. The aim of this study was to investigate the expression of cannabinoid (CB) receptors using Western blot and CB1 receptor density using autoradiography after acute or chronic administration of antidepressant drugs [imipramine (IMI, 15mg/kg), escitalopram (ESC, 10mg/kg) and tianeptine (TIA, 10mg/kg)]...
September 1, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28860775/a-case-of-paroxysmal-kinesigenic-dyskinesia-which-exhibited-the-phenotype-of-anxiety-disorder
#9
Yasuto Kunii, Nozomu Matsuda, Hirooki Yabe
BACKGROUND: Paroxysmal kinesigenic dyskinesia (PKD) is a rare heritable neurologic disorder characterized by attacks of involuntary movement induced by sudden voluntary movements. No previous reports have described cases showing comorbidity with psychiatric disease or symptoms. In this case, we showed a patient with PKD who exhibited several manifestations of anxiety disorder. CASE: A 35-year-old Japanese man with PKD had been maintained on carbamazepine since he was 16 years of age without any attacks...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28860564/differential-effects-of-antidepressant-treatment-on-long-range-and-short-range-functional-connectivity-strength-in-patients-with-major-depressive-disorder
#10
Jing An, Li Wang, Ke Li, Yawei Zeng, Yunai Su, Zhen Jin, Xin Yu, Tianmei Si
Although we have some basic understanding of the neurochemical mechanisms of the antidepressants, the network-level effect of antidepressant treatment is still not fully understood. This study was conducted to investigate the effects of antidepressant on functional brain networks of patients with major depressive disorder (MDD). We performed resting-state fMRI scans on 20 first-episode drug-naive MDD patients at baseline and after escitalopram medication for 8 weeks. Twenty healthy controls also received MRI scans with an 8-week interval...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28857719/a-randomized-double-blind-placebo-controlled-dose-ranging-study-of-lisdexamfetamine-dimesylate-augmentation-for-major-depressive-disorder-in-adults-with-inadequate-response-to-antidepressant-therapy
#11
Cynthia Richards, Dan V Iosifescu, Rajnish Mago, Elias Sarkis, James Reynolds, Brooke Geibel, Matthew Dauphin
BACKGROUND: This randomized, double-blind, placebo-controlled study evaluated dose-response relationships of lisdexamfetamine dimesylate when used as augmentation for major depressive disorder in individuals exhibiting inadequate responses to antidepressant monotherapy. METHODS: Eligible adults (18-65 years) were assigned to antidepressant monotherapy (escitalopram or venlafaxine extended-release) plus lisdexamfetamine dimesylate-matching placebo during an eight-week single-blind lead-in phase...
August 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28857309/impact-of-the-black-triangle-label-on-prescribing-of-new-drugs-in-the-united-kingdom-lessons-for-the-united-states-at-a-time-of-deregulation
#12
Daniel B Horton, Tobias Gerhard, Amy Davidow, Brian L Strom
PURPOSE: Newly approved novel drugs in Europe receive a black triangle label to promote pharmacovigilance. With growing momentum for earlier drug approvals and reliance on real-world evidence, we studied if the black triangle label promotes more judicious prescribing. METHODS: We examined whether general practitioners prescribed escitalopram, tadalafil, and vardenafil with a black triangle more cautiously than the same or similar drugs without a black triangle in The Health Improvement Network (UK)...
August 31, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28854817/in-vitro-genotoxic-and-cytotoxic-effects-of-doxepin-and-escitalopram-on-human-peripheral-lymphocytes
#13
Hayal Cobanoglu, Mahmut Coskun, Akin Çayir, Munevver Coskun
Antidepressants are drugs used for the treatment of many psychiatric conditions including depression. There are findings suggesting that these drugs might have genotoxic, carcinogenic, and/or mutagenic effects. Therefore, the present in vitro study is intended to investigate potential genotoxic and cytotoxic effects of the antidepressants escitalopram (selective serotonin reuptake inhibitor) and doxepin (Tricyclic antidepressant) on human peripheral lymphocytes cytokinesis-block micronucleus (CBMN), sister chromatid exchange (SCE), and single cell gel electrophoresis (alkaline comet assay) were used for the purpose of the study...
August 31, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/28852260/-the-barking-girl-a-case-report-of-psychogenic-cough-in-a-child-with-a-review-of-literature
#14
Praveen Kumar Jakati, Subrata Naskar, Anisha Khanna
A 9-year-old girl presented with 2-month history of continuous coughing; despite detailed evaluation, no organic cause was found. Considering the provisional diagnosis of a psychogenic cough, she was advised for psychiatry consultation. After a psychological assessment, she was found to have comorbid anxiety (Screen for Child Anxiety Related Disorders score- 25) along with punitive parenting and sibling rivalry issues. She was initially treated with parental psychoeducation, play therapy, and behavior therapy...
July 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28831260/an-observational-study-of-duloxetine-versus-ssri-monotherapy-in-japanese-patients-with-major-depressive-disorder-subgroup-analyses-of-treatment-effectiveness-for-pain-depressive-symptoms-and-quality-of-life
#15
Atsushi Kuga, Toshinaga Tsuji, Shinji Hayashi, Shinji Fujikoshi, Hirofumi Tokuoka, Aki Yoshikawa, Rodrigo Escobar, Kazuhide Tanaka, Takaharu Azekawa
OBJECTIVE: To examine how clinical and demographic patient baseline characteristics influence effectiveness of duloxetine versus selective serotonin reuptake inhibitor (SSRI) treatment, in real-world Japanese clinical settings of patients with major depressive disorder (MDD) and associated painful physical symptoms (PPS). METHODS: This was a multicenter, 12-week, prospective, observational study in patients with MDD (Quick Inventory of Depressive Symptomatology ≥16) and at least moderate PPS (Brief Pain Inventory-Short Form [BPI-SF] average pain ≥3)...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28831259/an-observational-study-of-duloxetine-versus-ssri-monotherapy-for-the-treatment-of-painful-physical-symptoms-in-japanese-patients-with-major-depressive-disorder-primary-analysis
#16
Atsushi Kuga, Toshinaga Tsuji, Shinji Hayashi, Mako Matsubara, Shinji Fujikoshi, Hirofumi Tokuoka, Aki Yoshikawa, Rodrigo Escobar, Kazuhide Tanaka, Takaharu Azekawa
OBJECTIVE: The objective of this study was to assess the effectiveness of duloxetine monotherapy, in comparison with selective serotonin reuptake inhibitor (SSRI) monotherapy, in the treatment of painful physical symptoms (PPS) in Japanese patients with major depressive disorder (MDD) in real-world clinical settings. METHODS: This was a multicenter, 12-week prospective, observational study. This study enrolled MDD patients with at least moderate PPS, defined as a Brief Pain Inventory-Short Form (BPI-SF) average pain score (item 5) ≥3...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28827861/the-prospective-24-week-assessment-of-cost-efficacy-of-and-compliance-to-antidepressant-medications-in-a-rural-setting-pacecar-study
#17
T S Sathyanarayana Rao, J Shivanand Manohar, Rajesh Raman, M S Darshan, Abhinav Tandon, K N Karthik, N Saraswathi, Keya Das, G T Harsha, Swetha Patil Kunkeri, Chittaranjan Andrade
BACKGROUND: Anxiety and depression are common mental health disorders that are responsible for considerable societal burden. There are no data on cost-efficacy and medication compliance related to the treatment of these disorders in rural India. MATERIALS AND METHODS: All consenting adults (n = 455) diagnosed with generalized anxiety or (unipolar) depressive disorders in Suttur village, Karnataka, were treated with open-label fluoxetine (20-60 mg/day), sertraline (50-150 mg/day), escitalopram (10-20 mg/day), desvenlafaxine (50-150 mg/day), duloxetine (30-90 mg/day), amitriptyline (75-150 mg/day), or clomipramine (75-150 mg/day) in a structured, monotherapy dosing plan...
April 2017: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28815595/sigma-1-receptor-ligands-inhibit-catecholamine-secretion-from-adrenal-chromaffin-cells-due-to-block-of-nicotinic-acetylcholine-receptors
#18
Rebecca L Brindley, Mary Beth Bauer, Nolan D Hartley, Kyle J Horning, Kevin P M Currie
Adrenal chromaffin cells (ACCs) are the neuroendocrine arm of the sympathetic nervous system and key mediators of the physiological stress response. Acetylcholine (ACh) released from preganglionic splanchnic nerves activates nicotinic acetylcholine receptors (nAChRs) on chromaffin cells causing membrane depolarization, opening voltage-gated Ca(2+) channels (VGCC), and exocytosis of catecholamines and neuropeptides. The serotonin transporter (SERT) is expressed in ACCs and interacts with 5-HT1A receptors to control secretion...
August 16, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28808405/catha-edulis-forsk-khat-evaluation-of-its-antidepressant-like-activity
#19
Hassan Alfaifi, Siddig Ibrahim Abdelwahab, Syam Mohan, Manal Mohamed Elhassan Taha, Sohier M Syame, Lamiaa A Shaala, Rashad Alsanosy
BACKGROUND: Catha edulis Forsk. (Khat) is traditionally used for treating various disorders. Nevertheless there are no reports of any scientific assessment of its psychopharmacological properties. OBJECTIVE: Therefore, the current study was designed to evaluate the antidepressant-like activity of Khat ethanolic extract using established animal models of depression and stress. MATERIALS AND METHODS: Ninety healthy male albino mice were used in this study...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28793999/association-of-qt-prolonging-medication-use-in-ckd-with-electrocardiographic-manifestations
#20
Soren Snitker, Rebecca M Doerfler, Elsayed Z Soliman, Rajat Deo, Wendy L St Peter, Susan Kramlik, Michael J Fischer, Sankar Navaneethan, Patrice Delafontaine, Bernard G Jaar, Akinlolu Ojo, Gail K Makos, Anne Slaven, Matthew R Weir, Min Zhan, Jeffrey C Fink
BACKGROUND AND OBJECTIVES: Several drugs used in CKD can prolong electrocardiographic conduction. We examined the use of electrocardiogram QT-prolonging medications in predialysis CKD and their association with QT duration. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In total, 3252 Chronic Renal Insufficiency Cohort participants with at least one study electrocardiogram between 2003 and 2011 were included. QT-prolonging medications used in 100 or more visits (n=16,451 visits) along with diuretics and proton pump inhibitors, given their potential for electrolyte disturbances, were examined for QT interval prolongation...
August 9, 2017: Clinical Journal of the American Society of Nephrology: CJASN
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