keyword
https://read.qxmd.com/read/36125911/protective-alpha1-antitrypsin-effects-in-autoimmune-vasculitis-are-compromised-by-methionine-oxidation
#1
JOURNAL ARTICLE
Maximilian Jp Ebert, Uwe Jerke, Claudia Eulenberg-Gustavus, Lovis Kling, Dieter E Jenne, Marieluise Kirchner, Philipp Mertins, Markus Bieringer, Saban Elitok, Kai-Uwe Eckardt, Adrian Schreiber, Alan D Salama, Ralph Kettritz
BACKGROUND: Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitidies (AAV) are life-threatening systemic autoimmune conditions. ANCA directed against proteinase 3 (PR3) or myeloperoxidase (MPO) bind their cell surface-presented antigen, activate neutrophils and cause vasculitis. An imbalance between PR3 and its major inhibitor α1-antitrypsin (AAT) was proposed to underlie PR3- but not MPO-AAV. We measured AAT and PR3 in healthies and AAV patients and studied protective AAT effects pertaining to PR3- and MPO-ANCA...
September 20, 2022: Journal of Clinical Investigation
https://read.qxmd.com/read/34943555/pulmonary-vasculitides-a-radiological-review-emphasizing-parenchymal-hrct-features
#2
REVIEW
Stefano Palmucci, Corrado Inì, Salvatore Cosentino, Luigi Fanzone, Stefano Di Pietro, Alessia Di Mari, Federica Galioto, Francesco Tiralongo, Giovanna Vignigni, Stefano Toscano, Gianluca Sambataro, Carlo Vancheri, Giulio Distefano, Antonio Basile
Vasculitides represent a heterogeneous group of immune-mediated disorders, characterized by a systemic inflammatory destructive process of the blood vessels resulting either in ischemia or hemorrhage. The organ involved and vessel size influence the pattern of presentation of the pathology. The lung is commonly involved in systemic vasculitides, with heterogeneous clinical, radiological, and histopathological presentations. Primary vasculitides most commonly associated with lung parenchymal involvement include small-vessel antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides, such as granulomatosis with polyangiitis (GPA), eosinophilic granulomatosis with polyangiitis (EGPA), and microscopic polyangiitis (MPA)...
December 9, 2021: Diagnostics
https://read.qxmd.com/read/32018021/hiv-associated-aortitis-causing-rapid-development-of-an-abdominal-aortic-aneurysm
#3
REVIEW
Ashley Rosenberg, Pamela Bailey, Margaret Rigamer, Mark Levy
Vasculitides are rare manifestations of human immunodeficiency virus (HIV) infection. They encompass a wide range of different pathologies, both infectious and noninfectious. We present the case of a 68-year-old female with HIV, being treated with antiretrovirals, who presented with a symptomatic abdominal aortic aneurysm. The aneurysm developed within one week. The patient underwent endovascular aneurysm repair, and her aneurysm completely resolved on follow-up computed tomography imaging 16 months later...
July 2020: Annals of Vascular Surgery
https://read.qxmd.com/read/30533405/s100a12-serum-levels-and-pmn-counts-are-elevated-in-childhood-systemic-vasculitides-especially-involving-proteinase-3-specific-anti-neutrophil-cytoplasmic-antibodies
#4
JOURNAL ARTICLE
Kelly L Brown, Joanna M Lubieniecka, Giulia Armaroli, Katharina Kessel, Kristen M Gibson, Jinko Graham, Dongmeng Liu, Robert E W Hancock, Colin J Ross, Susanne M Benseler, Raashid A Luqmani, David A Cabral, Dirk Foell, Christoph Kessel
Objectives: Chronic primary systemic vasculitidies (CPV) are a collection of rare diseases involving inflammation in blood vessels, often in multiple organs. CPV can affect adults and children and may be life- or organ-threatening. Treatments for adult CPV, although effective, have known severe potential toxicities; safety and efficacy of these drugs in pediatric patients is not fully understood. There is an unmet need for biologic measures to assess the level of disease activity and, in turn, inform treatment choices for stopping, starting, or modifying therapy...
2018: Frontiers in Pediatrics
https://read.qxmd.com/read/30509707/pulmonary-manifestations-of-large-medium-and-variable-vessel-vasculitis
#5
REVIEW
Traci N Adams, Da Zhang, Kiran Batra, John E Fitzgerald
The hallmark of vasculitis is autoimmune inflammation of blood vessels and surrounding tissues, resulting in an array of constitutional symptoms and organ damage. The lung is commonly targeted in the more familiar ANCA-associated small vessel vasculitidies, but large and medium vessel vasculitides, including Takayasu arteritis, giant cell arteritis, polyarteritis nodosa, Behcet's disease, and necrotizing sarcoid granulomatosis, may also feature prominent pulmonary involvement. Pulmonary manifestations of these conditions include pulmonary arterial aneurysms, pulmonary hypertension, diffuse alveolar hemorrhage, pulmonary nodules, and parenchymal infiltrates...
December 2018: Respiratory Medicine
https://read.qxmd.com/read/27545842/current-trends-in-autoimmunity-and-the-nervous-system
#6
REVIEW
Carlo Selmi, Jobert G Barin, Noel R Rose
In the broad field of autoimmunity and clinical immunology, experimental evidence over the past few years have demonstrated several connections between the immune system and the nervous system, both central and peripheral, leading to the definition of neuroimmunology and of an immune-brain axis. Indeed, the central nervous system as an immune-privileged site, thanks to the blood-brain barrier, is no longer a dogma as the barrier may be altered during chronic inflammation with disruptive changes of endothelial cells and tight junctions, largely mediated by adenosine receptors and the expression of CD39/CD73...
December 2016: Journal of Autoimmunity
https://read.qxmd.com/read/25776140/cutaneous-vasculitidis-histology-and-immunofluorescence
#7
REVIEW
A Filosa, A Verdelli, B Bianchi, E Del Bianco, L Bugatti, G Filosa, M Caproni
Cutaneous vasculitis comprises a wide spectrum of diseases that involve predominantly the blood vessels and surrounding tissues of the skin. Few vasculitic syndromes have pathognomonic clinical, radiographic and/or laboratory findings; thus, confident and accurate diagnosis of vasculitis requires histological confirmation. Skin biopsy should be done, optimally within 24 to 48 hours after vasculitic lesions appear. Deep excision biopsy must be preferred. Direct immunofluorescence of lesional skin is helpful in the diagnosis of vasculitides in the light of a proper clinico-pathological setting and diagnostic in some peculiarly forms...
April 2015: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://read.qxmd.com/read/25265937/the-risk-of-deep-venous-thrombosis-and-pulmonary-embolism-in-giant-cell-arteritis-a-general-population-based-study
#8
JOURNAL ARTICLE
J Antonio Aviña-Zubieta, Vidula M Bhole, Neda Amiri, Eric C Sayre, Hyon K Choi
IMPORTANCE: Patients with giant cell arteritis (GCA) may have an increased risk of pulmonary embolism (PE), similar to other systemic vasculitidies; however, no relevant population data are available to date. OBJECTIVE: To evaluate the future risk and time trends of new venous thromboembolism (VTE) in individuals with incident GCA at the general population level. DESIGN: Observational cohort study. SETTING: General population of British Columbia...
January 2016: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/25056155/the-immunopathology-of-anca-associated-vasculitis
#9
REVIEW
Eoin F McKinney, Lisa C Willcocks, Verena Broecker, Kenneth G C Smith
The small-vessel vasculitides are a group of disorders characterised by variable patterns of small blood vessel inflammation producing a markedly heterogeneous clinical phenotype. While any vessel in any organ may be involved, distinct but often overlapping sets of clinical features have allowed the description of three subtypes associated with the presence of circulating anti-neutrophil cytoplasmic antibodies (ANCA), namely granulomatosis with polyangiitis (GPA, formerly known as Wegener's Granulomatosis), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (eGPA, formerly known as Churg-Strauss syndrome)...
July 2014: Seminars in Immunopathology
https://read.qxmd.com/read/23683962/therapeutic-update-in-large-vessel-vasculitides
#10
REVIEW
S Pérez-Esteban, M A González-Gay, S Castañeda
The term large vessel vasculitidis includes two distinct clinical entities: Takayasu's arteritis and giant cell arteritis. Takayasu's arteritis mainly affects children and women under 40 years, affecting the aorta and its major branches. Its incidence in Southern Europe is low. Giant cell arteritis is the most common vasculitis in those 60. Its incidence in the European population is greater than that of Takayasu's arteritis. It mainly affects the extracranial vessels, especially those derived from the carotid artery...
October 2013: Revista Clínica Espanõla
https://read.qxmd.com/read/23591909/gastrointestinal-mucosal-involvement-without-amyloidosis-in-children-with-familial-mediterranean-fever
#11
JOURNAL ARTICLE
Odul Egritas Gurkan, Buket Dalgic
BACKGROUND AND OBJECTIVES: Familial Mediterranean fever (FMF) and inflammatory bowel disease togetherness is well described in the literature. Abdominal pain and various gastrointestinal manifestations may arise directly from FMF or secondary to FMF-associated diseases such as inflammatory bowel disease, vasculitidies, or amyloidosis. The aim of the study was to document gastrointestinal involvement in familial Mediterranean fever. METHODS: The medical files of the patients who were diagnosed as having FMF at the Department of Pediatric Gastroenterology, Gazi University School of Medicine between 2007 and 2012 were examined retrospectively...
September 2013: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/22673387/antineutrophil-cytoplasm-autoantibodies-usefulness-in-rheumatology
#12
REVIEW
Luis Felipe Flores-Suárez
The primary vasculitidies are complex diseases with varied clinical manifestations, which may be common to those present in multiple diseases. The antineutrophil cytoplasm autoantibodies (ANCA) led to a revolution in the diagnosis and research of these diseases, being the first and so far, the only biomarkers for three of these diseases, which affect small caliber vessels. From their description, much progress has been made, but there are still gray or misunderstood areas regarding their best use in the clinic...
November 2012: Reumatología Clinica
https://read.qxmd.com/read/22119278/-advances-in-the-diagnosis-of-large-vessel-vasculitis-identification-of-biomarkers-and-imaging-studies
#13
REVIEW
Ignacio Villa, Mario Agudo Bilbao, Víctor M Martínez-Taboada
Depending on the geographic area and the affected age group, large vessel vasculitis (LVV) are one of the most frequent types of systemic vasculitidies. Whereas giant cell arteritis (GCA) occurs exclusively in elderly individuals and is more frequent in countries with European ancestry, Takayasús arteritis (TA) mainly affects young women from eastern countries. The diagnosis of these disorders has been based on the characteristic clinical picture, together with the typical histopathological features in the temporal artery of patients with GCA, and the angiography results in TA patients...
December 2011: Reumatología Clinica
https://read.qxmd.com/read/22115871/-role-of-the-ears-nose-and-throat-specialist-in-the-diagnosis-and-follow-up-of-patients-with-primary-vasculitidies
#14
REVIEW
Olga E Beltrán Rodríguez Cabo, Gabriel Tona Acedo
First manifestations of vasculitis can appear on the head and neck, still few physicians are aware of these diseases, as they are unspecific and because other conditions like infections and allergies are more frequent. Among them, signs and symptoms like epistaxis, nasal obstruction, discharge, burning pain of sinonasal region, headache, sinus polyps and crusts, the latter found in people who live in highly polluted cities with low humidity, in patients with respiratory scleroma, atrophy, those receiving local radiotherapy, and due to other conditions...
December 2011: Reumatología Clinica
https://read.qxmd.com/read/22115870/-approach-and-challenges-in-primary-vasculitidies
#15
REVIEW
Beatriz Zazueta Montiel, Luis Felipe Flores Suárez
The primary systemic vasculitidies (PSV) comprise an heterogeneous group of complex clinical entities with a common substrate: inflammation and necrosis of blood vessels. The inflammatory process involves vessels of any caliber. The location and the different size of the affected vessels, the severity of vascular damage and the different histopathological patterns which may predominate are the basic characteristics that define the different vasculitic syndromes and enable individualization. The description and progress in the knowledge of the primary vasculitidies have evolved considerably in recent decades, allowing for a better resolution of the complex problems placed by these patients...
December 2011: Reumatología Clinica
https://read.qxmd.com/read/21762728/cross-talk-between-the-complement-and-the-kinin-system-in-vascular-permeability
#16
REVIEW
Fleur Bossi, Ellinor I Peerschke, Berhane Ghebrehiwet, Francesco Tedesco
The endothelium is a continuous physical barrier that regulates coagulation and selective passage of soluble molecules and circulating cells through the vessel wall into the tissue. Due to its anatomic localization, the endothelium may establish contact with components of the complement, the kinin and the coagulation systems which are the main, though not exclusive, inducers of vascular leakage. Although the complement and the kinin systems may act independently, increasing evidence suggest that there is a crosstalk that involve different components of both systems...
October 30, 2011: Immunology Letters
https://read.qxmd.com/read/21179985/ct-angiography-evaluation-of-the-renal-vascular-pathologies-a-pictorial-review
#17
REVIEW
M Oz, T Hazirolan, B Turkbey, A D Karaosmanoglu, M Canyigit, B Peynircioglu
The emergence of CT angiography (CTA) has a groundbreaking impact on the evaluation of renal vessels and is gradually replacing the conventional catheter angiography as the standard imaging procedure. In this review, we aimed to describe the renal CTA technique and imaging findings of several renal arterial (i.e. atherosclerosis, fibromuscular dysplasia, aneurysms of the renal arteries, dissection, vasculitidis, follow-up of patients with renal arterial stent) and venous (i.e. nut-cracker syndrome, pelvic congestion syndrome) pathologies...
September 2010: JBR-BTR: Organe de la Société Royale Belge de Radiologie (SRBR)
https://read.qxmd.com/read/20360980/myocardial-ischemia-in-wegener-s-granulomatosis-coronary-atherosclerosis-versus-vasculitis
#18
JOURNAL ARTICLE
Giuseppe Cocco, Armen Yuri Gasparyan
Wegener's granulomatosis (WG) is one of the most common small- and medium-sized necrotizing vasculitides that mainly affects the upper and lower respiratory tract and the kidneys. Cardiac manifestations in WG are relatively rare, and their role and place among different causes of mortality remain largely unknown. Substantially increased number of reports describing involvement of all structures of the heart, which underlie conduction disturbances, valvular disease, ischemic heart disease and other potentially serious conditions, underscores importance of comprehensive cardiovascular investigations and monitoring of patients with WG...
February 23, 2010: Open Cardiovascular Medicine Journal
https://read.qxmd.com/read/19834724/vertigo-and-autoimmunity
#19
REVIEW
Roberto Bovo, Andrea Ciorba, Alessandro Martini
Autoimmune inner ear disease probably accounts for less than 1% of all cases of balance disorders, but its incidence is often overlooked due to the absence of a specific diagnostic test. Furthermore, in several systemic autoimmune diseases the vestibulo-cochlear system may be affected. Clinical features comprise generalized imbalance, ataxia, motion intolerance, episodic vertigo and positional vertigo. An autoimmune mechanism seems to be responsible for 6% of unilateral and 16% of bilateral forms of Ménière's disease...
January 2010: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/19734736/fatal-aortic-dissection-due-to-a-fulminant-variety-of-isolated-aortitis
#20
REVIEW
Hilary F Ryder, Laura J Tafe, Christopher M Burns
Aortitis is typically a chronic, progressive disease manifestation associated with large vessel vasculitidies, most notably giant cell, Takayasu arteritis, and a newly described entity, isolated aortitis. The aortitis may lead to aneurysm formation and symptoms associated with branch vessel occlusion in these diseases, but aortic dissection is rare and usually a late complication of smoldering, incompletely treated disease. We present a case of aortitis in a previously healthy 39-year-old man who succumbed to aortic dissection hours after the onset of symptoms...
September 2009: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
keyword
keyword
74525
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.