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Medical informatics standards

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https://www.readbyqxmd.com/read/29313057/regional-differences-in-thrombectomy-rates-secondary-use-of-billing-codes-in-the-miracum-medical-informatics-for-research-and-care-in-university-medicine-consortium
#1
Christian Haverkamp, Thomas Ganslandt, Petar Horki, Martin Boeker, Arnd Dörfler, Stefan Schwab, Joachim Berkefeld, Waltraud Pfeilschifter, Wolf-Dirk Niesen, Karl Egger, Manfred Kaps, Marc A Brockmann, Eva Neumaier-Probst, Kristina Szabo, Martin Skalej, Siegfried Bien, Christoph Best, Hans-Ulrich Prokosch, Horst Urbach
BACKGROUND AND PURPOSE: Mechanical thrombectomy, in addition to intravenous (i.v.) thrombolysis is recommended for treatment of acute stroke in patients with large vessel occlusions (LVO) in the anterior circulation up to 6 h after symptom onset. We compared thrombectomy rates of eight university hospitals of the MIRACUM consortium to analyze the implementation of this guideline in clinical routine. METHODS: Anonymized billing data in a standardized format were loaded into a local i2b2 data warehouse by applying already existing extract, transform and load (ETL) routines...
January 8, 2018: Clinical Neuroradiology
https://www.readbyqxmd.com/read/29298192/helping-older-adults-improve-their-medication-experience-home-by-addressing-medication-regimen-complexity-in-home-healthcare
#2
Orla C Sheehan, Hadi Kharrazi, Kimberly J Carl, Bruce Leff, Jennifer L Wolff, David L Roth, Jennifer Gabbard, Cynthia M Boyd
In skilled home healthcare (SHHC), communication between nurses and physicians is often inadequate for medication reconciliation and needed changes to the medication regimens are rarely made. Fragmentation of electronic health record (EHR) systems, transitions of care, lack of physician-nurse in-person contact, and poor understanding of medications by patients and their families put patients at risk for serious adverse outcomes. The aim of this study was to develop and test the HOME tool, an informatics tool to improve communication about medication regimens, share the insights of home care nurses with physicians, and highlight to physicians and nurses the complexity of medication schedules...
January 2018: Home Healthcare Now
https://www.readbyqxmd.com/read/29285339/medium-chain-acyl-coa-dehydrogenase-deficiency-in-a-premature-infant
#3
Steven F Dobrowolski, Lina Ghaloul-Gonzalez, Jerry Vockley
Medium-chain acyl-CoA dehydrogenase deficiency (MCADD) is identified by newborn screening (NBS). The natural history of MCADD includes metabolic decompensation with hypoglycemia, hyperammonemia, seizures, coma, and death. NBS enables expectant management thus severe symptoms are rare in managed patients. We report premature birth of an MCADD affected infant and resultant management challenges. Nutritional support advanced from parenteral nutrition at 24 hours to enteral feeds. A NBS sample was collected day 2, positive results for MCADD was reported day six, and diagnostic tests were performed day seven...
November 21, 2017: Pediatric Reports
https://www.readbyqxmd.com/read/29284292/the-national-rare-diseases-registry-system-nrdrs-of-china-and-the-related-cohort-studies-vision-and-roadmap
#4
Shi Feng, Shuang Liu, Chong Zhu, Mengchun Gong, Yicheng Zhu, Shuyang Zhang
Rare diseases are major challenges in healthcare and medical research and have been involved in national development strategies in many countries. However, inadequate definition of rare diseases and lags in orphan drug development in China hinder rare diseases research. The first nationwide rare diseases registry system, National Rare Diseases Registry System of China (NRDRS) has been established and various cohort studies have been launched since 2016. More than 20 top academic institutions participate in this joint effort to carry out nationwide registration of rare diseases...
December 28, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/29247099/evidence-assessing-the-diagnostic-performance-of-medical-smartphone-apps-a-systematic-review-and-exploratory-meta-analysis
#5
Rahel Buechi, Livia Faes, Lucas M Bachmann, Michael A Thiel, Nicolas S Bodmer, Martin K Schmid, Oliver Job, Kenny R Lienhard
OBJECTIVE: The number of mobile applications addressing health topics is increasing. Whether these apps underwent scientific evaluation is unclear. We comprehensively assessed papers investigating the diagnostic value of available diagnostic health applications using inbuilt smartphone sensors. METHODS: Systematic Review-MEDLINE, Scopus, Web of Science inclusive Medical Informatics and Business Source Premier (by citation of reference) were searched from inception until 15 December 2016...
December 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29226007/houston-methodist-variant-viewer-an-application-to-support-clinical-laboratory-interpretation-of-next-generation-sequencing-data-for-cancer
#6
Paul A Christensen, Yunyun Ni, Feifei Bao, Heather L Hendrickson, Michael Greenwood, Jessica S Thomas, S Wesley Long, Randall J Olsen
Introduction: Next-generation-sequencing (NGS) is increasingly used in clinical and research protocols for patients with cancer. NGS assays are routinely used in clinical laboratories to detect mutations bearing on cancer diagnosis, prognosis and personalized therapy. A typical assay may interrogate 50 or more gene targets that encompass many thousands of possible gene variants. Analysis of NGS data in cancer is a labor-intensive process that can become overwhelming to the molecular pathologist or research scientist...
2017: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/29154853/standards-and-guidelines-for-validating-next-generation-sequencing-bioinformatics-pipelines-a-joint-recommendation-of-the-association-for-molecular-pathology-and-the-college-of-american-pathologists
#7
REVIEW
Somak Roy, Christopher Coldren, Arivarasan Karunamurthy, Nefize S Kip, Eric W Klee, Stephen E Lincoln, Annette Leon, Mrudula Pullambhatla, Robyn L Temple-Smolkin, Karl V Voelkerding, Chen Wang, Alexis B Carter
Bioinformatics pipelines are an integral component of next-generation sequencing (NGS). Processing raw sequence data to detect genomic alterations has significant impact on disease management and patient care. Because of the lack of published guidance, there is currently a high degree of variability in how members of the global molecular genetics and pathology community establish and validate bioinformatics pipelines. Improperly developed, validated, and/or monitored pipelines may generate inaccurate results that may have negative consequences for patient care...
November 17, 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/29132622/know-thy-ehealth-user-development-of-biopsychosocial-personas-from-a-study-of-older-adults-with-heart-failure
#8
Richard J Holden, Anand Kulanthaivel, Saptarshi Purkayastha, Kathryn M Goggins, Sunil Kripalani
BACKGROUND: Personas are a canonical user-centered design method increasingly used in health informatics research. Personas-empirically-derived user archetypes-can be used by eHealth designers to gain a robust understanding of their target end users such as patients. OBJECTIVE: To develop biopsychosocial personas of older patients with heart failure using quantitative analysis of survey data. METHOD: Data were collected using standardized surveys and medical record abstraction from 32 older adults with heart failure recently hospitalized for acute heart failure exacerbation...
December 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29114115/data-requirements-and-the-basis-for-designing-health-information-kiosks
#9
REVIEW
Mina Afzali, Maryam Ahmadi, Zahra Mahmoudvand
Introduction: Health kiosks are an innovative and cost-effective solution that organizations can easily implement to help educate people. Aim: To determine the data requirements and basis for designing health information kiosks as a new technology to maintain the health of society. Methods: By reviewing the literature, a list of information requirements was provided in 4 sections (demographic information, general information, diagnostic information and medical history), and questions related to the objectives, data elements, stakeholders, requirements, infrastructures and the applications of health information kiosks were provided...
September 2017: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/29084368/electronic-health-record-phenotypes-for-precision-medicine-perspectives-and-caveats-from-treatment-of-breast-cancer-at-a-single-institution
#10
Matthew K Breitenstein, Hongfang Liu, Kara N Maxwell, Jyotishman Pathak, Rui Zhang
Precision medicine is at the forefront of biomedical research. Cancer registries provide rich perspectives and electronic health record(EHR)s are commonly utilized to gather additional clinical data elements needed for translational research. However, manual annotation is resource-intense and not readily scalable. Informatics-based phenotyping presents an ideal solution, but perspectives obtained can be impacted by both data source and algorithm selection. We derived breast cancer(BC) receptor status phenotypes from structured and unstructured EHR data using rule-based algorithms, including natural language processing(NLP)...
October 30, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/29063565/clinical-research-informatics-supporting-the-research-study-lifecycle
#11
S B Johnson
Objectives: The primary goal of this review is to summarize significant developments in the field of Clinical Research Informatics (CRI) over the years 2015-2016. The secondary goal is to contribute to a deeper understanding of CRI as a field, through the development of a strategy for searching and classifying CRI publications. Methods: A search strategy was developed to query the PubMed database, using medical subject headings to both select and exclude articles, and filtering publications by date and other characteristics...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29063556/knowledge-representation-and-management-it-s-time-to-integrate
#12
F Dhombres, J Charlet
Objectives: To select, present, and summarize the best papers published in 2016 in the field of Knowledge Representation and Management (KRM). Methods: A comprehensive and standardized review of the medical informatics literature was performed based on a PubMed query. Results: Among the 1,421 retrieved papers, the review process resulted in the selection of four best papers focused on the integration of heterogeneous data via the development and the alignment of terminological resources. In the first article, the authors provide a curated and standardized version of the publicly available US FDA Adverse Event Reporting System...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29063555/representing-knowledge-consistently-across-health-systems
#13
S T Rosenbloom, R J Carroll, J L Warner, M E Matheny, J C Denny
Objectives: Electronic health records (EHRs) have increasingly emerged as a powerful source of clinical data that can be leveraged for reuse in research and in modular health apps that integrate into diverse health information technologies. A key challenge to these use cases is representing the knowledge contained within data from different EHR systems in a uniform fashion. Method: We reviewed several recent studies covering the knowledge representation in the common data models for the Observational Medical Outcomes Partnership (OMOP) and its Observational Health Data Sciences and Informatics program, and the United States Patient Centered Outcomes Research Network (PCORNet)...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29063549/an-assessment-of-imaging-informatics-for-precision-medicine-in-cancer
#14
C Chennubhotla, L P Clarke, A Fedorov, D Foran, G Harris, E Helton, R Nordstrom, F Prior, D Rubin, J H Saltz, E Shalley, A Sharma
Objectives: Precision medicine requires the measurement, quantification, and cataloging of medical characteristics to identify the most effective medical intervention. However, the amount of available data exceeds our current capacity to extract meaningful information. We examine the informatics needs to achieve precision medicine from the perspective of quantitative imaging and oncology. Methods: The National Cancer Institute (NCI) organized several workshops on the topic of medical imaging and precision medicine...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29063538/health-information-management-changing-with-time
#15
S H Fenton, S Low, K J Abrams, K Butler-Henderson
Objective: With the evolution of patient medical records from paper to electronic media and the changes to the way data is sourced, used, and managed, there is an opportunity for health information management (HIM) to learn and facilitate the increasing expanse of available patient data. Methods: This paper discusses the emerging trends and lessons learnt in relation with the following four areas: 1) data and information governance, 2) terminology standards certification, 3) International Classification of Diseases, 11th edition (ICD-11), and 4) data analytics and HIM...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/28903073/reconciling-disparate-information-in-continuity-of-care-documents-piloting-a-system-to-consolidate-structured-clinical-documents
#16
Masoud Hosseini, Josette Jones, Anthony Faiola, Daniel J Vreeman, Huanmei Wu, Brian E Dixon
BACKGROUND: Due to the nature of information generation in health care, clinical documents contain duplicate and sometimes conflicting information. Recent implementation of Health Information Exchange (HIE) mechanisms in which clinical summary documents are exchanged among disparate health care organizations can proliferate duplicate and conflicting information. MATERIALS AND METHODS: To reduce information overload, a system to automatically consolidate information across multiple clinical summary documents was developed for an HIE network...
October 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28895104/concordance-of-adherence-measurement-using-self-reported-adherence-questionnaires-and-medication-monitoring-devices-an-updated-review
#17
REVIEW
Alisha Monnette, Yichen Zhang, Hui Shao, Lizheng Shi
INTRODUCTION: As medication adherence continues to be a prevalent issue in today's society, the methods used to monitor medication-taking behaviors are constantly being re-evaluated and compared in search of the 'gold standard' measure. Our review aimed to assess the current literature surrounding the correlation between self-reported questionnaires (SRQs) and electronic monitoring devices to determine if these measures produce similar results. METHODS: We performed a literature search from 2009 to 2017 using PubMed, PubMed In-Process and Non-Indexed, EMBASE, Ovid MEDLINE, and Ovid MEDLINE In-Process...
September 11, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28883196/from-a-content-delivery-portal-to-a-knowledge-management-system-for-standardized-cancer-documentation
#18
Danijela Schlue, Sebastian Mate, Jörg Haier, Dennis Kadioglu, Hans-Ulrich Prokosch, Bernhard Breil
Heterogeneous tumor documentation and its challenges of interpretation of medical terms lead to problems in analyses of data from clinical and epidemiological cancer registries. The objective of this project was to design, implement and improve a national content delivery portal for oncological terms. Data elements of existing handbooks and documentation sources were analyzed, combined and summarized by medical experts of different comprehensive cancer centers. Informatics experts created a generic data model based on an existing metadata repository...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28883166/standards-based-procedural-phenotyping-the-arden-syntax-on-i2b2
#19
Sebastian Mate, Ixchel Castellanos, Thomas Ganslandt, Hans-Ulrich Prokosch, Stefan Kraus
Phenotyping, or the identification of patient cohorts, is a recurring challenge in medical informatics. While there are open source tools such as i2b2 that address this problem by providing user-friendly querying interfaces, these platforms lack semantic expressiveness to model complex phenotyping algorithms. The Arden Syntax provides procedural programming language construct, designed specifically for medical decision support and knowledge transfer. In this work, we investigate how language constructs of the Arden Syntax can be used for generic phenotyping...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28840966/the-diy-digital-medical-centre
#20
James Kenneth Timmis, Kenneth Timmis
Healthcare systems worldwide are confronted with major economic, organizational and logistical challenges. Historic evolution of health care has led to significant healthcare sector fragmentation, resulting in systemic inefficiencies and suboptimal resource exploitation. To attain a sustainable healthcare model, fundamental, system-wide improvements that effectively network, and ensure fulfilment of potential synergies between sectors, and include and facilitate coherent strategic planning and organisation of healthcare infrastructure are needed...
September 2017: Microbial Biotechnology
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