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https://www.readbyqxmd.com/read/28332165/low-microchimeric-cell-density-in-tumors-suggests-alternative-antineoplastic-mechanism
#1
Timothy W Jolis, Brenna M Brucker, Christoph Schorl, James N Butera, Peter J Quesenberry
Microchimerism has generally been shown to protect against cancer (Gilmore et al. in Exp Hematol 36(9):1073-1077, 2008). The mechanism of how this occurs is an area of intense study, as it may lead to new cancer treatments. The leading theory is that microchimeric cells perform immune surveillance by directly fighting cancerous cells and that they also act as stem cells, repairing damaged tissue (Khosrotehrani et al. in JAMA 292:75-80, 2004). However, there is conflicting evidence to support this theory. Several small studies have found few microchimeric cells in tumor tissue (Gadi in Breast Cancer Res Treat 121(1):241-244, 2010; Cirello et al...
April 2017: Medical Oncology
https://www.readbyqxmd.com/read/28325713/two-decades-of-cardiovascular-trials-with-primary-surrogate-endpoints-1990-2011
#2
Behnood Bikdeli, Natdanai Punnanithinont, Yasir Akram, Ike Lee, Nihar R Desai, Joseph S Ross, Harlan M Krumholz
BACKGROUND: Surrogate endpoint trials test strategies more efficiently but are accompanied by uncertainty about the relationship between changes in surrogate markers and clinical outcomes. METHODS AND RESULTS: We identified cardiovascular trials with primary surrogate endpoints published in the New England Journal of Medicine, Lancet, and JAMA: Journal of the American Medical Association from 1990 to 2011 and determined the trends in publication of surrogate endpoint trials and the success of the trials in meeting their primary endpoints...
March 21, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28324059/jama
#3
(no author information available yet)
No abstract text is available yet for this article.
March 14, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28322491/threats-to-reliability-risk-erroneous-conclusions-a-survey-of-prospective-registration-and-sample-sizes-of-randomised-trials-in-women-s-health
#4
S K Nijjar, K S Khan
OBJECTIVE: Prospective registration of clinical trials has been required since 2005. We aimed to assess concordance between registered and reported sample sizes among prospectively registered randomised controlled trials (RCTs) in obstetrics and gynaecology. DESIGN: Analysis of prospectively registered and published data. SETTING: Women's health. SAMPLE: Obstetrics and gynaecology RCTs published in eight journals in 2015...
March 21, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28314888/youtube-provides-poor-information-regarding-anterior-cruciate-ligament-injury-and-reconstruction
#5
J T Cassidy, E Fitzgerald, E S Cassidy, M Cleary, D P Byrne, B M Devitt, J F Baker
PURPOSE: YouTube is a global medium used predominantly by young adults (aged 18-49 years). This study examined the quality of YouTube information regarding ACL injury and reconstruction. METHODS: YouTube was searched on the 13th of June 2015 for "ACL" and "anterior cruciate ligament" with/without associated terms of "injury", "reconstruction", and "surgery". Videos were evaluated by two independent reviewers [EF (Reviewer 1), (Reviewer 2)] using two recognized information scoring systems (Modified DISCERN (MD) 0-5 and JAMA Benchmark 0-4) and an adaptation of a score designed for written ACL information [ACL Specific Score (ASS) 0-25]...
March 17, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28301665/jama-otolaryngology-head-neck-surgery
#6
(no author information available yet)
No abstract text is available yet for this article.
March 1, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28297024/jama-cardiology-list-of-peer-reviewers
#7
(no author information available yet)
No abstract text is available yet for this article.
March 15, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28297019/jama-cardiology
#8
(no author information available yet)
No abstract text is available yet for this article.
March 1, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28297008/jama-surgery-2016-year-in-review
#9
Melina R Kibbe
No abstract text is available yet for this article.
March 15, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28296997/jama-cardiology-inaugural-year-in-review
#10
Robert O Bonow
No abstract text is available yet for this article.
March 15, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28296996/jama-surgery-peer-review-list
#11
(no author information available yet)
No abstract text is available yet for this article.
March 15, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28294069/wallet-neuritis-an-example-of-peripheral-sensitization
#12
Md Abu Bakar Siddiq, Israt Jahan, Sam Masihuzzaman
BACKGROUND: Wallet neuritis is an example of extra-spinal tunnel neuropathy concerning sciatic nerve. Its clinical appearance often gets confused with sciatica of lumbar spine origin. Wallet-induced chronic sciatic nerve constriction produces gluteal and ipsilateral lower extremity pain, tingling, and burning sensation. It was Lutz, first describing credit-card wallet sciatica in an Attorney, surfaced on Journal of American Medical Association (JAMA), 1978; however, the condition has not been well-studied in various other occupations...
March 9, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28292317/the-association-of-funding-source-on-effect-size-in-randomized-controlled-trials-2013-2015-a-cross-sectional-survey-and-meta-analysis
#13
Alberto Falk Delgado, Anna Falk Delgado
BACKGROUND: Trials financed by for-profit organizations have been associated with favorable outcomes of new treatments, although the effect size of funding source impact on outcome is unknown. The aim of this study was to estimate the effect size for a favorable outcome in randomized controlled trials (RCTs), stratified by funding source, that have been published in general medical journals. METHODS: Parallel-group RCTs published in The Lancet, New England Journal of Medicine, and JAMA between 2013 and 2015 were identified...
March 14, 2017: Trials
https://www.readbyqxmd.com/read/28291897/jama
#14
(no author information available yet)
No abstract text is available yet for this article.
March 14, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28288267/jama-pediatrics-peer-review-list
#15
(no author information available yet)
No abstract text is available yet for this article.
March 13, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28288242/jama-pediatrics-2016-year-in-review
#16
Frederick P Rivara
No abstract text is available yet for this article.
March 13, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28284713/air-quality-environmental-epidemiology-studies-are-unreliable
#17
S Stanley Young
Ever since the London Great Smog of 1952 is estimated to have killed over 4000 people, scientists have studied the relationship between air quality and acute mortality. There are many hundreds of papers examining the question. There is a serious statistical problem with most of these papers. If there are many questions under consideration, and there is no adjustment for multiple testing or multiple modeling, then unadjusted p-values are totally unreliable making claims unreliable. Our idea is to determine the statistical reliability of eight papers published in Environmental Health Perspectives that were used in meta-analysis papers appearing in Lancet and JAMA...
March 8, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28278347/jama-ophthalmology
#18
(no author information available yet)
No abstract text is available yet for this article.
March 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28278332/jama-oncology
#19
(no author information available yet)
No abstract text is available yet for this article.
March 1, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28273312/jama-dermatology
#20
(no author information available yet)
No abstract text is available yet for this article.
March 1, 2017: JAMA Dermatology
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