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https://www.readbyqxmd.com/read/29351393/liver-tissue-metabolically-transformed-by-alcohol-induces-immune-recognition-of-liver-self-proteins-but-not-in-vivo-inflammation
#1
Michael J Duryee, Benjamin M Wiese, Jordan R Bowman, Jared D Vanlandingham, Lynell W Klassen, Geoffrey E Thiele, Carlos D Hunter, Daniel R Anderson, Ted R Mikuls, Geoffrey M Thiele
Precision cut liver slices (PCLSs) provide a novel model for studies in alcoholic liver disease (ALD). This is relevant, as in vivo ethanol exposure does not appear to generate significant liver damage in ethanol fed mice, except in the NIAAA binge model of ALD. Previous studies have shown that the two metabolites of ethanol consumption, malondialdhyde (MDA) and acetaldehyde (AA), combine to form (MAA), which has been correlated with the development and progression of ALD. In this study murine PCLSs were incubated with ethanol and examined for the production of MAA...
December 28, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29350900/fluorescent-tpa-gqds-probe-for-sensitive-assay-and-quantitative-imaging-of-hydroxyl-radical-in-living-cells
#2
Xin Hai, Zhiyong Guo, Xin Lin, Xuwei Chen, Jian-Hua Wang
A fluorescent probe TPA@GQDs is fabricated by the conjugation of terephthalic acid (TPA) on the surface of graphene quantum dots (GQDs). The TPA@GQDs probe not only owns favorable dispersibility, but also exhibits excellent fluorescence stability over wide pH range and high ionic strength, and favorable anti-photobleaching ability. The great fluorescence enhancement of TPA@GQDs induced by the reaction between TPA and hydroxyl radical makes the TPA@GQDs a powerful probe for the sensitive assay of hydroxyl radical, giving rise to a detection limit low down to 12 nmol L-1...
January 19, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29350899/cyclam-modified-pei-for-combined-vegf-sirna-silencing-and-cxcr4-inhibition-to-treat-metastatic-breast-cancer
#3
Yiwen Zhou, Fei Yu, Feiran Zhang, Gang Chen, Kaikai Wang, Minjie Sun, Jing Li, David Oupický
Chemokine receptor CXCR4 plays an important role in cancer cell invasion and metastasis. Recent findings suggest that anti-VEGF therapies upregulate CXCR4 expression, which contributes to resistance to antiangiogenic therapies. Here, we report the development of novel derivatives of polyethylenimine (PEI) that effectively inhibit CXCR4 while delivering anti-VEGF siRNA. PEI was alkylated with different amounts of a CXCR4-binding cyclam derivative to prepare PEI-C. Modification with the cyclam derivatives resulted in a considerable decrease in cytotoxicity when compared with unmodified PEI...
January 19, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29350748/protective-effect-of-chitosan-oligosaccharides-against-cyclophosphamide-induced-immunosuppression-and-irradiation-injury-in-mice
#4
Xingchen Zhai, Xin Yang, Pan Zou, Yong Shao, Shoujun Yuan, A M Abd El-Aty, Jing Wang
Chitosan oligosaccharides (COS), hydrolyzed products of chitosan, was found to display various biological activities. Herein, we assessed the immunostimulatory activity of COS both in in vitro and in vivo studies. In vitro cytotoxicity studies to murine macrophage RAW264.7 revealed that COS is safe even at the maximum tested concentration of 1000 μg/mL. It also stimulates the production of nitric oxide (NO) and tumor necrosis factor (TNF-α) and enhances the phagocytosis in COS-stimulated RAW264.7. We have shown that the COS could significantly (P < 0...
January 19, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29350716/three-dimensional-multiscale-fiber-matrices-development-and-characterization-for-increased-hepg2-functional-maintenance-for-bio-artificial-liver-application
#5
Surendra Kumar Verma, Akshay Modi, Jayesh Bellare
The development of a cell-growth substrate that provides a nature-like microenvironment, promotes cell adhesion, and maintains the cells' functional activities is a research focus in the field of tissue engineering. In the present study, three-dimensional micro-nano multiscale fiber-based substrates were developed by depositing biocompatible polycaprolactone (PCL)/PCL-Chitosan (C)/PCL-C-Gelatin (G) electrospun nanofibers (NFs) on the outer surface of hollow fiber membranes (HFMs) in one step. A comparison study with regard to physico-chemical characterization, hemocompatibility, cytotoxicity, and cellular functionality was performed with the developed matrices...
January 19, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29350596/enhancement-of-antitumor-activity-by-using-5-ala-mediated-sonodynamic-therapy-to-induce-apoptosis-in-malignant-gliomas-significance-of-high-intensity-focused-ultrasound-on-5-ala-sdt-in-a-mouse-glioma-model
#6
Satoshi Suehiro, Takanori Ohnishi, Daisuke Yamashita, Shohei Kohno, Akihiro Inoue, Masahiro Nishikawa, Shiro Ohue, Junya Tanaka, Takeharu Kunieda
OBJECTIVE High invasiveness of malignant gliomas frequently causes early local recurrence of the tumor, resulting in extremely poor outcome. To control such recurrence, novel therapies targeted toward infiltrating glioma cells around the tumor border are required. Here, the authors investigated the antitumor activity of sonodynamic therapy (SDT) combined with a sonosensitizer, 5-aminolevulinic acid (5-ALA), on malignant gliomas to explore the possibility for clinical use of 5-ALA-mediated SDT (5-ALA-SDT). METHODS In vitro cytotoxicity of 5-ALA-SDT was evaluated in U87 and U251 glioma cells and in U251Oct-3/4 glioma stemlike cells...
January 19, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29350566/abp-501-for-the-treatment-of-rheumatoid-arthritis
#7
Eleftherios Pelechas, Paraskevi V Voulgari, Alexandros A Drosos
Rheumatoid arthritis (RA) is an autoimmune disease, which has a negative impact on the ability to perform activities daily. Tumour necrosis factor α (TNF) is a cytokine with diverse cellular effects, and a key regulator of the inflammatory response. ABP 501 is a biosimilar to adalimumab, a TNF inhibitor. Areas covered: In this review, we examined ABP 501, as a biosimilar candidate to adalimumab in the treatment of RA focusing on the available data. Current data indicate that ABP 501 is a highly similar alternative to adalimumab in terms of safety, efficacy, tolerability and immunogenicity...
January 19, 2018: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/29350467/alveolar-soft-part-sarcoma-in-children-and-young-adults-a-report-of-69-cases
#8
Ricardo J Flores, Douglas J Harrison, Noah C Federman, Wayne L Furman, Winston W Huh, Emily G Broaddus, Mehmet F Okcu, Rajkumar Venkatramani
BACKGROUND: Alveolar soft part sarcoma (ASPS) is a rare mesenchymal tumor characterized by ASPL-TFE3 translocation. Apart from complete surgical resection, there is no standard management strategy. PROCEDURE: The clinical data of 69 children and young adults less than 30 years old with ASPS diagnosed from 1980-2014 were retrospectively collected from four major institutions. RESULTS: Median age at diagnosis was 17 years (range: 1.5-30). Forty-four (64%) were female...
January 19, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29350433/amino-group-of-salicylic-acid-exhibits-enhanced-inhibitory-potential-against-insulin-amyloid-fibrillation-with-protective-aptitude-toward-amyloid-induced-cytotoxicity
#9
Masihuz Zaman, Mohsin Vahid Khan, Syed Mohammad Zakariya, Saima Nusrat, Syed Mustapha Meeran, Parvez Alam, Mohammad Rehan Ajmal, Wahiduzzaman Wahiduzzaman, Yasser E Shahein, Amira M Abouelella, Rizwan Hasan Khan
Protein misfolding and aggregation lead to amyloid generation that in turn may induce cell membrane disruption and leads to cell apoptosis. In an effort to prevent or treat amyloidogenesis, large number of studies has been paying attention on breakthrough of amyloid inhibitors. In the present work, we aim to access the effect of two drugs, that is, acetylsalicylic acid and 5-amino salicylic acid on insulin amyloids by using various biophysical, imaging, cell viability assay, and computational approaches. We established that both drugs reduce the turbidity, light scattering and fluorescence intensity of amyloid indicator dye thioflavin T...
December 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29350342/mesenchymal-stromal-cells-of-the-bone-marrow-and-natural-killer-cells-cell-interactions-and-cross-modulation
#10
Mehdi Najar, Mohammad Fayyad-Kazan, Nathalie Meuleman, Dominique Bron, Hussein Fayyad-Kazan, Laurence Lagneaux
Bone marrow-derived mesenchymal stromal cells (BM-MSCs) are multipotent progenitor cells that have shown promise for several different therapeutic applications. As they are able to modulate the function of several types of immune cells, BM-MSCs are highly important in the field of cell-based immunotherapy. Understanding BM-MSC-natural killer (NK) cell interactions is crucial for improving their therapeutic efficiency. Here, we observed that the type of NK cell-activating cytokine (e.g., IL-2, IL-12, IL-15 and IL-21) strongly influenced the outcomes of their interactions with BM-MSCs...
January 19, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29350306/progress-on-the-study-of-the-mechanism-of-busulfan-cytotoxicity
#11
REVIEW
Xiaoli Chen, Mingyuan Liang, Dong Wang
The preparation of spermatogonial stem cell (SSC) transplant recipients laid the technical foundation for SSC transplant technology and the understanding of spermatogenesis mechanisms. Busulfan is commonly used to prepare recipients for mouse SSC transplantation; however, its safety and efficiency have been questioned. This review summarizes the relationship between SSCs and Sertoli cells (SCs), and the mechanism of busulfan toxicity against sperm cells. We concluded that the proliferation, differentiation, and apoptosis of SSCs are regulated by SCs...
January 19, 2018: Cytotechnology
https://www.readbyqxmd.com/read/29350299/mutagenicity-cytotoxic-and-antioxidant-activities-of-ricinus-communis-different-parts
#12
Mazhar Abbas, Abid Ali, Muhammad Arshad, Asia Atta, Zahed Mehmood, Imtiaz Mahmood Tahir, Munawar Iqbal
Ricinus communis (castor plant) is a potent medicinal plant, which is commonly used in the treatment of various ailments. The present study was conducted to appraise the cytotoxicity and mutagenicity of R. communis along with antioxidant and antimicrobial activities. Cytotoxicity was evaluated by hemolytic and brine shrimp assays, whereas Ames test (TA98 and TA100) was used for mutagenicity evaluation. Plant different parts were extracted in methanol by shaking, sonication and Soxhlet extraction methods. The R...
January 19, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/29350186/mri-tracing-non-invasive-tio2-based-nanoparticles-motivated-by-ultrasound-for-multi-mechanism-therapy-of-prostatic-cancer
#13
Pu Yuan, Dongkui Song
To reduce the side effects of chemotherapy and reach effective and safe therapy of prostate cancer, herein, a simple but multifunctional system TiO2:Gd@DOX/FA motivated by ultrasound was developed for MRI guided multi-mechanism therapy of prostate cancer. TiO2 nanoparticles served as a sonosensitizer as well as a nanocarrier with pH-responsive release of DOX. Doping of Gd could not only endow TiO2 the ability of magnetic resonance imaging (MRI), but also further improve sonodynamic ability of TiO2. The characterization revealed the as-prepared TiO2:Gd@DOX/FA showed sensitive pH-responsive drug release, high ROS production, T1-MRI contrast performance and excellent biocompatibility...
January 19, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29350096/%C3%AE-tocopherol-protected-against-cobalt-nanoparticles-and-cocl2-induced-cytotoxicity-and-inflammation-in-balb-3t3-cells
#14
Xin Yan, Yake Liu, Tian Xie, Fan Liu
CONTEXT: Currently, tissue damage induced by cobalt nanoparticles (CoNPs) and cobalt ions (Co2+) are the most serious adverse effect in the patients with metal-on-metal hip prostheses. Therefore, an urgent need exists for the identification of the mechanisms and the development of therapeutic strategies to limit it. OBJECTIVE: We aimed to explore the mechanisms of cytotoxicity of CoNPs and Co2+ and developed strategies to reduce this cytotoxicity with α-tocopherol treatment...
January 19, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29350064/comparison-of-hyaluronic-acid-based-micelles-and-polyethylene-glycol-based-micelles-on-reversal-of-multidrug-resistance-and-enhanced-anticancer-efficacy-in-vitro-and-in-vivo
#15
Jinling Wang, Ying Li, Lifang Wang, Xiaohui Wang, Pengfei Tu
Polyethylene glycol (PEG)-based block copolymer micelles and hyaluronic acid (HA)-based grafted copolymer micelles have been widely investigated in chemotherapy. In this study, to evaluate the differences among HA-based grafted polymer micelles, PEG-based block polymer micelles and the mixed of these two micelles in enhancing antitumor effects and overcoming MDR, two amphiphilic vitamin E succinate (VES) derivatives, HA VES (HA-g-VES) and PEG 2000 VES (TPGS2k), were applied as nanocarriers to prepare HA-VES micelles (HA-PMs), TPGS2k micelles (TPGS2k-PMs) and the mixed micelles (HA/TPGS2k-PMs) for the co-delivery of doxorubicin (DOX) and curcumin (Cur)...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29350056/new-isolates-from-leaves-of-nicotiana-tabacum-and-their-biological-activities
#16
Shanzhai Shang, Jianlian Shi, Jianguo Tang, Juxing Jiang, Wei Zhao, Xudong Zheng, Ping Lei, Jingmei Han, Chengya Wang, Dalin Yuan, Guangyu Yang, Yongkuan Chen, Mingming Miao
Three new isolates (1-3) including one new sterol and two new flavonoids together with three known sterols (4-6) were isolated from the leaves of Nicotiana tabacum. Their structures were determined mainly by spectroscopic methods, including extensive 1D and 2D NMR techniques. All compounds were evaluated for their anti-tobacco mosaic virus and cytotoxic activities. The results showed that compounds 2 and 3 exhibited high anti-TMV activity with inhibition rate of 34.2 and 33.4%, respectively, which were roughly equivalent to that of positive control...
January 19, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29350054/caloinophyllin-a-a-new-chromanone-derivative-from-calophyllum-inophyllum-roots
#17
Sasa Ponguschariyagul, Jirapast Sichaem, Suttira Khumkratok, Pongpun Siripong, Kiattisak Lugsanangarm, Santi Tip-Pyang
A new chromanone derivative, namely caloinophyllin A (1), along with eight known compounds (2-9), nobiletin (2), pentamethylquercetin (3), 3,5,7,4'-tetramethoxyflavone (4), 5,7,4'-trimethoxyflavone (5), 1,5-dihydroxyxanthone (6), 1,8-dimethoxy-2-hydroxyxanthone (7), 1,6-dihydroxy-7-methoxyxanthone (8) and 4-methoxycaffeic acid (9) were isolated from the roots of Calophyllum inophyllum. The structures of all the isolated compounds (1-9) were fully characterised using spectroscopic data, as well as comparison with the previous literature data...
January 19, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29349927/treatment-related-toxicities-of-immune-checkpoint-inhibitors-in-advanced-cancers-a-meta-analysis
#18
Johnathan Man, Georgia Ritchie, Matthew Links, Sally Lord, Chee Khoon Lee
BACKGROUND: We performed a meta-analysis to quantify toxic death, adverse events (AEs) and treatment discontinuation due to AEs from checkpoint inhibitors (CI). METHODS: We searched for randomized trials with adequate reporting for toxicity outcomes. Pooled risk ratios were estimated for CI versus chemotherapy or different combinations of these agents. RESULTS: Twenty trials of five different cancers with 10 794 patients with performance status 0 or 1 were identified...
January 19, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29349894/assessment-of-the-potential-of-temporin-peptides-from-the-frog-rana-temporaria-ranidae-as-anti-diabetic-agents
#19
Vishal Musale, Bruno Casciaro, Maria Luisa Mangoni, Yasser H A Abdel-Wahab, Peter R Flatt, J Michael Conlon
Temporin A (FLPLIGRVLSGIL-NH2 ), temporin F (FLPLIGKVLSGIL-NH2 ), and temporin G (FFPVIGRILNGIL-NH2 ), first identified in skin secretions of the frog Rana temporaria, produced concentration-dependent stimulation of insulin release from BRIN-BD11 rat clonal β-cells at concentrations ≥1 nM, without cytotoxicity at concentrations up to 3 μM. Temporin A was the most effective. The mechanism of insulinotropic action did not involve an increase in intracellular Ca2+ concentrations. Temporins B, C, E, H, and K were either inactive or only weakly active...
January 19, 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/29349835/optimization-of-aqueous-extraction-from-kalanchoe-pinnata-leaves-to-obtain-the-highest-content-of-an-anti-inflammatory-flavonoid-using-a-response-surface-model
#20
Luana Beatriz Dos Santos Nascimento, Paula Fernandes de Aguiar, Marcos Vinicius Leal-Costa, Marcela Araújo Soares Coutinho, Maria Paula Gonçalves Borsodi, Bartira Rossi-Bergmann, Eliana Schwartz Tavares, Sônia Soares Costa
INTRODUCTION: The medicinal plant Kalanchoe pinnata is a phenolic-rich species used worldwide. The reports on its pharmacological uses have increased by 70% in the last 10 years. The leaves of this plant are the main source of an unusual quercetin-diglycosyl flavonoid (QAR, quercetin arabinopyranosyl rhamnopyranoside), which can be easily extracted using water. QAR possess a strong in vivo anti-inflammatory activity. OBJECTIVE: To optimize the aqueous extraction of QAR from K...
January 19, 2018: Phytochemical Analysis: PCA
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