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Neurodevelopmental outcomes

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https://www.readbyqxmd.com/read/28925578/combined-fetal-inflammation-and-postnatal-hypoxia-causes-myelin-deficits-and-autism-like-behavior-in-a-rat-model-of-diffuse-white-matter-injury
#1
Erik van Tilborg, E J Marijke Achterberg, Caren M van Kammen, Annette van der Toorn, Floris Groenendaal, Rick M Dijkhuizen, Cobi J Heijnen, Louk J M J Vanderschuren, Manon N J L Benders, Cora H A Nijboer
Diffuse white matter injury (WMI) is a serious problem in extremely preterm infants, and is associated with adverse neurodevelopmental outcome, including cognitive impairments and an increased risk of autism-spectrum disorders. Important risk factors include fetal or perinatal inflammatory insults and fluctuating cerebral oxygenation. However, the exact mechanisms underlying diffuse WMI are not fully understood and no treatment options are currently available. The use of clinically relevant animal models is crucial to advance knowledge on the pathophysiology of diffuse WMI, allowing the definition of novel therapeutic targets...
September 19, 2017: Glia
https://www.readbyqxmd.com/read/28925538/maternal-intelligence-quotient-iq-predicts-iq-and-language-in-very-preterm-children-at-age-5%C3%A2-years
#2
Rachel E Lean, Rachel A Paul, Christopher D Smyser, Cynthia E Rogers
BACKGROUND: Sociodemographic factors are linked to cognitive outcomes in children born very preterm (VPT; ≤30 weeks gestation). The influence of maternal intellectual ability, a heritable trait, is unknown. Also undetermined is the extent to which associations between maternal and child intellectual ability vary according to parenting behaviors that target cognitive stimulation in the home. METHODS: At age 5 years, 84 VPT and 38 demographically matched full-term (FT) children underwent neurodevelopmental assessment...
September 19, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28925315/prognostic-value-of-brain-magnetic-resonance-imaging-in-neonatal-hypoxic-ischemic-encephalopathy-a-meta-analysis
#3
Iván Sánchez Fernández, J Leon Morales-Quezada, Samuel Law, Paggie Kim
OBJECTIVE: To quantify the prognostic value of neonatal brain magnetic resonance imaging (MRI) in neonatal hypoxic-ischemic encephalopathy. METHODS: Meta-analysis of studies with ≥35-week neonates with hypoxic-ischemic encephalopathy who underwent brain MRI within age 4 weeks and had neurodevelopmental follow-up for at least 12 months. RESULTS: An abnormal neonatal brain MRI was more frequent among patients with unfavorable neurodevelopmental outcome: odds ratio = 18...
January 1, 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28924555/early-changes-in-brain-structure-correlate-with-language-outcomes-in-children-with-neonatal-encephalopathy
#4
Kevin A Shapiro, Hosung Kim, Maria Luisa Mandelli, Elizabeth E Rogers, Dawn Gano, Donna M Ferriero, A James Barkovich, Maria Luisa Gorno-Tempini, Hannah C Glass, Duan Xu
Global patterns of brain injury correlate with motor, cognitive, and language outcomes in survivors of neonatal encephalopathy (NE). However, it is still unclear whether local changes in brain structure predict specific deficits. We therefore examined whether differences in brain structure at 6 months of age are associated with neurodevelopmental outcomes in this population. We enrolled 32 children with NE, performed structural brain MR imaging at 6 months, and assessed neurodevelopmental outcomes at 30 months...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28922987/admissions-for-hypoglycaemia-after-35%C3%A2-weeks-of-gestation-perinatal-predictors-of-cost-of-stay
#5
Theodore Dassios, Anne Greenough, Stamatina Leontiadi, Ann Hickey, Nick Kametas
BACKGROUND: Hypoglycaemia accounts for approximately one tenth of term admissions to neonatal units, can cause long-term neurodevelopmental impairment and is associated with significant burden to the affected infants, families and the health system. OBJECTIVE: To define the prevalence, length and cost of admissions for hypoglycaemia in infants born at greater than 35 weeks gestation and to identify antenatal and perinatal predictors of those outcomes. MATERIAL AND METHODS: This was a retrospective audit of infants admitted for hypoglycaemia between 1/1/2012 and 31/12/2015, in a level three neonatal intensive care unit at King's College Hospital NHS Foundation Trust, London...
September 18, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28915901/possible-effects-of-an-early-diagnosis-and-treatment-in-patients-with-growth-hormone-deficiency-the-state-of-art
#6
REVIEW
Stefano Stagi, Perla Scalini, Giovanni Farello, Alberto Verrotti
Growth hormone deficiency (GHD) is a relatively uncommon and heterogeneous endocrine disorder presenting in childhood with short stature. However, during the neonatal period, the metabolic effects of GHD may to require prompt replacement therapy to avoid possible life-threatening complications. An increasing amount of data suggests the importance of an early diagnosis and treatment of GHD because of its auxological, metabolic, and neurodevelopmental features with respect to the patients diagnosed and treated later in life...
September 16, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28915839/risk-of-mortality-among-children-adolescents-and-adults-with-autism-spectrum-disorder-or-attention-deficit-hyperactivity-disorder-and-their-first-degree-relatives-a-protocol-for-a-systematic-review-and-meta-analysis-of-observational-studies
#7
Ferrán Catalá-López, Brian Hutton, Matthew J Page, Manuel Ridao, Jane A Driver, Adolfo Alonso-Arroyo, Jaume Forés-Martos, Diego Macías Saint-Gerons, Eduard Vieta, Alfonso Valencia, Rafael Tabarés-Seisdedos
BACKGROUND: Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are childhood onset neurodevelopmental disorders that may persist into adulthood. ASD and ADHD tend to run in families and may have a significant negative impact on the health and longevity of those with the disorder and their relatives. The aim of this study will be to analyze the risk of mortality among children, adolescents, and adults with ASD or ADHD and their first-degree relatives. METHODS/DESIGN: We will conduct a systematic review and meta-analysis of observational studies...
September 15, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28915232/effects-of-early-nutrition-and-growth-on-brain-volumes-white-matter-microstructure-and-neurodevelopmental-outcome-in-preterm-newborns
#8
Caterina Coviello, Kristin Keunen, Karina J Kersbergen, Floris Groenendaal, Alexander Leemans, Barbara Peels, Ivana Isgum, Max A Viergever, Linda S de Vries, Giuseppe Buonocore, Virgilio P Carnielli, Manon J N L Benders
BACKGROUND: This study aimed to investigate the effect of nutrition and growth during the first 4 weeks after birth on cerebral volumes and white matter maturation at term equivalent age(TEA) and on neurodevelopmental outcome at 2 years corrected age(CA), in preterm infants. METHODS: 131 infants born at a gestational age(GA)<31weeks with MRI at TEA were studied. Cortical gray matter volumes(CGM), basal ganglia and thalami(BGT) volumes, cerebellar volumes and total brain volume(TBV) were computed...
September 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28915231/postnatal-polyunsaturated-fatty-acids-associated-with-larger-preterm-brain-tissue-volumes-and-better-outcomes
#9
Daphne Kamino, Colin Studholme, Mengyuan Liu, Vann Chau, Steven P Miller, Anne Synnes, Elizabeth E Rogers, A James Barkovich, Donna M Ferriero, Rollin Brant, Emily W Y Tam
BACKGROUND: Human studies investigating the link between postnatal polyunsaturated fatty acids and preterm brain growth are limited, despite emerging evidence of potential effects on outcomes. METHODS: Sixty preterm neonates <32 weeks gestational age with MRI scanning at near-birth and near-term age were assessed for brain tissue volumes including cortical grey matter, white matter, deep grey matter, cerebellum, brainstem and ventricular cerebrospinal fluid. Red blood cell fatty acid content was evaluated within 1 week of each MRI scan...
September 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28915132/clinical-update-regarding-general-anesthesia-associated-neurotoxicity-in-infants-and-children
#10
M Ruth Graham
PURPOSE OF REVIEW: The U.S. Federal Drug Administration (FDA) recently released a warning stating that 'repeated or lengthy use of general anesthetic and sedation drugs during surgeries or procedures in children younger than 3 years or in pregnant women during their third trimester may affect the development of children's brains' (www.fda.gov/ucm582356.htm). The goal of this article is to review the most recent clinical studies which provide evidence that these concerns may be overstated for the majority of healthy young children who require surgery and anesthesia...
September 14, 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/28913834/which-children-and-young-people-are-excluded-from-school-findings-from-a-large-british-birth-cohort-study-the-avon-longitudinal-study-of-parents-and-children-alspac
#11
A Paget, C Parker, J Heron, S Logan, W Henley, A Emond, T Ford
BACKGROUND: Exclusion from school is increasingly recognized as pertinent to child health. National educational data reveal that boys, children who are looked-after, living in poverty, have special educational needs, or from certain ethnic minorities, are disproportionately excluded from school. As population-based data on the wider characteristics of excluded children are scarce, we aimed to describe predictors of school exclusion in the Avon Longitudinal Study of Parents and Children...
September 14, 2017: Child: Care, Health and Development
https://www.readbyqxmd.com/read/28912368/neurodevelopment-of-hiv-exposed-and-hiv-unexposed-uninfected-children-at-24-months
#12
Sumona Chaudhury, Paige L Williams, Gloria K Mayondi, Jean Leidner, Penny Holding, Vicki Tepper, Sharon Nichols, Jane Magetse, Maureen Sakoi, Kebaiphe Moabi, Joseph Makhema, Charlotte Mdluli, Haruna Jibril, George R Seage, Betsy Kammerer, Shahin Lockman
BACKGROUND: We sought to determine if HIV-exposed uninfected (HEU) children had worse neurodevelopmental outcomes at 24 months compared with HIV-unexposed uninfected (HUU) children in Botswana. METHODS: HIV-infected and uninfected mothers enrolled in a prospective observational study ("Tshipidi") in Botswana from May 2010 to July 2012. Child neurodevelopment was assessed at 24 months with the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III: cognitive, gross motor, fine motor, expressive language, and receptive language domains) and the Development Milestones Checklist (DMC), a caregiver-completed questionnaire (locomotor, fine motor, language and personal-social domains)...
September 14, 2017: Pediatrics
https://www.readbyqxmd.com/read/28911050/motor-abnormalities-from-neurodevelopmental-to-neurodegenerative-through-functional-neuro-psychiatric-disorders
#13
Victor Peralta, Manuel J Cuesta
Background: Motor abnormalities (MAs) of severe mental disorders have been traditionally neglected both in clinical practice and research, although they are an increasing focus of attention because of their clinical and neurobiological relevance. For historical reasons, most of the literature on MAs has been focused to a great extent on schizophrenia, and as a consequence their prevalence and featural properties in other psychiatric or neuropsychiatric disorders are poorly known. In this article, we evaluated the extent to which catatonic, extrapyramidal and neurological soft signs, and their associated clinical features, are present transdiagnostically...
September 1, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28910243/fluoride-exposure-and-reported-learning-disability-diagnosis-among-canadian-children-implications-for-community-water-fluoridation
#14
Amanda M Barberio, Carlos Quiñonez, F Shaun Hosein, Lindsay McLaren
OBJECTIVES: Recent studies have connected increased fluoride exposure with increased risk of neurodevelopmental-related outcomes, such as ADHD (attention deficit hyperactivity disorder) and lower IQ in children. Our primary objective was to examine the association between fluoride exposure and reported diagnosis of a learning disability among a population-based sample of Canadian children aged 3-12 years. METHODS: We analyzed data from Cycles 2 and 3 of the Canadian Health Measures Survey...
September 14, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28905997/children-with-neurodevelopmental-disorders-and-disabilities-a-population-based-study-of-healthcare-service-utilization-using-administrative-data
#15
Rubab G Arim, Anton R Miller, Anne Guèvremont, Lucyna M Lach, Jamie C Brehaut, Dafna E Kohen
AIM: The aim of this study was to identify children with neurodevelopmental disorders and disabilities (NDD/D) and compare their healthcare service utilization to children without NDD/D using provincial linked administrative data. METHOD: The sample included children aged 6 to 10 years (n=183 041), who were registered with the British Columbia Medical Services Plan. Diagnostic information was used for the identification and classification of NDD/D in six functional domains...
September 14, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28901887/microcytosis-is-associated-with-low-cognitive-outcomes-in-healthy-2-year-olds-in-a-high-resource-setting
#16
Elaine K McCarthy, Mairead E Kiely, Geraldine Hannon, Caroline Ahearne, Louise C Kenny, Jonathan O'B Hourihane, Alan D Irvine, Deirdre M Murray
Fe deficiency in early childhood is associated with long-term consequences for cognitive, motor and behavioural development; however explorations in healthy children from low risk, high-resource settings have been limited. We aimed to explore associations between Fe status and neurodevelopmental outcomes in low risk, healthy 2-year-olds. This study was a secondary analysis of a nested case-control subgroup from the prospective, maternal-infant Cork Babies after Screening for Pregnancy Endpoints: Evaluating the Longitudinal Impact using Neurological and Nutritional Endpoints (BASELINE) Birth Cohort Study...
September 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28894999/needs-of-adolescents-and-young-adults-with-neurodevelopmental-disorders-comparisons-of-young-people-and-parent-perspectives
#17
Hanna Eklund, James Findon, Tim Cadman, Hannah Hayward, Declan Murphy, Philip Asherson, Karen Glaser, Kiriakos Xenitidis
This study used the Camberwell Assessment of Need for adults with Developmental and Intellectual Disabilities (CANDID) to examine the social, physical health and mental health needs of 168 young people (aged 14-24 years) with neurodevelopmental disorders and compared young person and parent ratings of need. Agreement was poor in 21 out of 25 domains. Parents consistently reported higher levels of need than young people in the majority of domains although young people with ADHD reported significantly more needs in physical health, eyesight/hearing, seizures, other mental health problems and safety of others than their parents...
September 11, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28892073/progress-and-roadblocks-in-the-search-for-brain-based-biomarkers-of-autism-and-attention-deficit-hyperactivity-disorder
#18
REVIEW
L Q Uddin, D R Dajani, W Voorhies, H Bednarz, R K Kana
Children with neurodevelopmental disorders benefit most from early interventions and treatments. The development and validation of brain-based biomarkers to aid in objective diagnosis can facilitate this important clinical aim. The objective of this review is to provide an overview of current progress in the use of neuroimaging to identify brain-based biomarkers for autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD), two prevalent neurodevelopmental disorders. We summarize empirical work that has laid the foundation for using neuroimaging to objectively quantify brain structure and function in ways that are beginning to be used in biomarker development, noting limitations of the data currently available...
August 22, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28891004/cerebral-imaging-and-neurodevelopmental-outcome-after-entero-and-human-parechovirus-sepsis-in-young-infants
#19
Eveline P de Jong, Herma C Holscher, Sylke J Steggerda, Jeanine M M Van Klink, Erika P M van Elzakker, Enrico Lopriore, Frans J Walther, Frank Brus
Enterovirus (EV) and human parechovirus (HPeV) are major causes of sepsis-like illness in infants under 90 days of age and have been identified as neurotropic. Studies about acute and long-term neurodevelopment in infants with sepsis-like illness without the need for intensive care are few. This study investigates cerebral imaging and neurodevelopmental outcome following EV and HPeV infection in these infants. We studied infants under 90 days of age who were admitted to a medium care unit with proven EV- or HPeV-induced sepsis-like illness...
September 10, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28888092/neurodevelopmental-outcome-at-the-age-of-4-years-according-to-the-planned-mode-of-delivery-in-term-breech-presentation-a-nationwide-population-based-record-linkage-study
#20
Georg Macharey, Mervi Väisänen-Tommiska, Mika Gissler, Veli-Matti Ulander, Leena Rahkonen, Mika Nuutila, Seppo Heinonen
PURPOSE: To evaluate whether a trial of planned vaginal breech labor affects neurologic development in children. METHODS: This is a nationwide, Finnish, population-based record linkage study. An odds ratio with 95% confidence intervals was used to estimate the relative risk that a child delivered by planned vaginal breech labor would be diagnosed with adverse neurodevelopmental outcome (cerebral palsy, epilepsy, intellectual disability, sensor neural developmental outcome, hyperactivity, speech and language problems) at the age of 4 years...
September 9, 2017: Journal of Perinatal Medicine
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