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https://www.readbyqxmd.com/read/28801176/caffeine-use-in-the-neonatal-intensive-care-unit
#1
REVIEW
Jalal M Abu-Shaweesh, Richard J Martin
Caffeine is the most frequently used medication in the neonatal intensive care unit. It is used for the prevention and treatment of apnea, although this has been associated with lower incidence of bronchopulmonary dysplasia (BPD) and patent ductus arteriosus as well as intact survival at 18-21 months of life. Although neurodevelopmental advantage was no longer statistically significant at age 5 years, caffeine was associated with sustained improvement in co-ordination and less gross motor impairment than placebo...
August 8, 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28800210/rates-of-early-intervention-services-in-children-born-extremely-preterm-extremely-low-birthweight
#2
Ianthe S Mills, Lex W Doyle, Jeanie Ly Cheong, Gehan Roberts
AIM: To determine the rates of early intervention (EI) service use in extremely preterm (EP, <28 weeks' gestation) or extremely low birthweight (ELBW, <1000 g) infants between 1991 and 2013, and identify biological or socio-economic factors associated with receiving EI. METHODS: Participants comprised consecutive EP or ELBW survivors born in 1991-1992, 1997 or 2005 in Victoria, Australia, and randomly selected, matched term-born controls. The main outcome measure was parent-reported EI participation up to 8 years of age...
August 11, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28793161/visuospatial-and-verbal-short-term-memory-correlates-of-vocabulary-ability-in-preschool-children
#3
Stephanie F Stokes, Thomas Klee, Myriam Kornisch, Lisa Furlong
Background: Recent studies indicate that school-age children's patterns of performance on measures of verbal and visuospatial short-term memory (STM) and working memory (WM) differ across types of neurodevelopmental disorders. Because these disorders are often characterized by early language delay, administering STM and WM tests to toddlers could improve prediction of neurodevelopmental outcomes. Toddler-appropriate verbal, but not visuospatial, STM and WM tasks are available. A toddler-appropriate visuospatial STM test is introduced...
August 9, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28792689/predictive-value-of-neurodevelopmental-outcome-and-serum-tau-protein-level-in-neonates-with-hypoxic-ischemic-encephalopathy
#4
Hong-Yan Lv, Su-Jing Wu, Xiu-Ling Gu, Qiu-Li Wang, Peng-Shun Ren, Yan Ma, Li-Ying Peng, Lin-Hong Jin, Lian-Xiang Li
BACKGROUND: Tau protein is s specific protein expressed by neurons in the central nervous system. Elevated serum Tau protein is associated with many diseases of the central nervous system. The serum Tau protein level in neonates with hypoxic ischemic encephalopathy (HIE) is still poorly understood. METHODS: Forty-one human neonates with HIE and thirty-five healthy neonates (control group) within 24 hours after birth were studied. Tau protein in serum was detected by enzyme-linked immunosorbent assay...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28791793/early-transition-from-insulin-to-sulfonylureas-in-neonatal-diabetes-and-follow-up-experience-from-china
#5
Xiuzhen Li, Aijing Xu, Huiying Sheng, Tzer Hwu Ting, Xiaojian Mao, Xinjiang Huang, Minyan Jiang, Jing Cheng, Li Liu
BACKGROUND: Sulfonylurea therapy can improve glycemic control and ameliorate neurodevelopmental outcomes in patients suffering from neonatal diabetes mellitus (NDM) with KCNJ11 or ABCC8 mutations. As genetic testing results are often delayed, it remains controversial whether sulfonylurea treatment should be attempted immediately at diagnosis or doctors should await genetic confirmation. OBJECTIVE: This study aimed to investigate the effectiveness and safety of sulfonylurea therapy in Chinese NDM patients during infancy before genetic testing results were available...
August 8, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28783802/association-of-neonatal-glycemia-with-neurodevelopmental-outcomes-at-4-5-years
#6
Christopher J D McKinlay, Jane M Alsweiler, Nicola S Anstice, Nataliia Burakevych, Arijit Chakraborty, J Geoffrey Chase, Gregory D Gamble, Deborah L Harris, Robert J Jacobs, Yannan Jiang, Nabin Paudel, Ryan J San Diego, Benjamin Thompson, Trecia A Wouldes, Jane E Harding
Importance: Hypoglycemia is common during neonatal transition and may cause permanent neurological impairment, but optimal intervention thresholds are unknown. Objective: To test the hypothesis that neurodevelopment at 4.5 years is related to the severity and frequency of neonatal hypoglycemia. Design, Setting, and Participants: The Children With Hypoglycemia and Their Later Development (CHYLD) Study is a prospective cohort investigation of moderate to late preterm and term infants born at risk of hypoglycemia...
August 7, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28782444/prenatal-abnormal-width-of-the-cavum-septum-pellucidum-mri-features-and-neurodevelopmental-outcome
#7
Shiri Cooper, Eldad Katorza, Michal Berkenstadt, Chen Hoffmann, Reuven Achiron, Omer Bar-Yosef
PURPOSE: To describe the morphological characteristics of fetal MRIs and outcome of prenatally-detected abnormal width of the CSP (cavum septum pellucidum). MATERIAL AND METHODS: A retrospective study of cases with abnormal width of the CSP demonstrated prenatally on MRI. Data collected included: prenatal history, MRI features, sonographic follow up, and neurodevelopmental outcome. RESULTS: Most of the cases referred (34/39) had an abnormal CSP on MRI...
August 6, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28780917/filling-a-significant-gap-in-the-cardiac-icu-implementation-of-individualised-developmental-care
#8
Samantha C Butler, Kate Huyler, Aditya Kaza, Chris Rachwal
Mortality rates among children with CHD have significantly declined, although the incidence of neurological abnormalities and neurodevelopmental impairment has increased. Research has focussed on outcomes, with limited attention on prevention and intervention. Although some developmental differences and challenges seen in children with CHD are explained by the cumulative effect of medical complications associated with CHD, many sequelae are not easily explained by medical complications alone. Although cardiac intensive care is lifesaving, it creates high levels of environmental and tactile stimulation, which potentially contribute to adverse neurodevelopmental outcomes...
August 7, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28780548/effect-of-single-family-rooms-for-preterm-infants-on-neurodevelopment-study-protocol-for-a-systematic-review
#9
Nicole R van Veenendaal, Sophie R D van der Schoor, Jacqueline Limpens, Anne A M W van Kempen, Johannes B van Goudoever
INTRODUCTION: Preterm infants are at an increased risk for neurodevelopmental delay. They have to endure many stressors in early life, including parent-infant separation, noise and painful procedures during hospitalisation in the highly technological environment of the modern neonatal ward. Currently, a shift is being noticed in the architectural design of neonatal wards towards single family rooms instead of the common open bay units. The influence of the hospital environment on health and specifically neurodevelopment in this vulnerable patient population remains under discussion...
August 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28780508/population-based-study-of-cognitive-outcomes-in-congenital-heart-defects
#10
Johanna Calderon, Marion Willaime, Nathalie Lelong, Damien Bonnet, Lucile Houyel, Morgane Ballon, François Goffinet, Babak Khoshnood
OBJECTIVE: To characterise and compare cognitive outcomes in children with operated (open-heart surgery) and non-operated (catheter-based interventions only or no intervention) congenital heart defects (CHD) and to determine associated risk factors. DESIGN: This prospective population-based study reports outcomes of 3-year-old children with CHD with or without open-heart surgery. MAIN OUTCOME MEASURES: Standardised cognitive scores (mean scores and proportions below normative values) were assessed with the Kaufman Assessment Battery for Children II...
August 5, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28772198/cerebral-regional-oxygen-saturation-trends-in-infants-with-hypoxic-ischemic-encephalopathy
#11
Siddharth V Jain, Lindsay Pagano, Maria Gillam-Krakauer, James C Slaughter, Sumit Pruthi, Barbara Engelhardt
BACKGROUND: Neurological outcomes in neonatal hypoxic-ischemic encephalopathy (HIE) continue to be sub-optimal despite therapeutic hypothermia (TH). Cerebral near-infrared spectroscopy provides real-time regional oxygen saturation (CrSO2) that may be a marker of adverse MRI findings and neurodevelopmental outcomes. AIM: The aim of this study was to examine the value of CrSO2 monitoring in infants with HIE undergoing TH. STUDY DESIGN AND SUBJECTS: In this prospective study, CrSO2 was continuously recorded in 21 infants with HIE admitted for TH...
July 31, 2017: Early Human Development
https://www.readbyqxmd.com/read/28768286/nicu-human-milk-dose-and-20-month-neurodevelopmental-outcome-in-very-low-birth-weight-infants
#12
Kousiki Patra, Matthew Hamilton, Tricia J Johnson, Michelle Greene, Elizabeth Dabrowski, Paula P Meier, Aloka L Patel
BACKGROUND: The association between human milk (HM) feeding in the NICU and neurodevelopmental (ND) outcome in very low birth weight (VLBW) infants is unclear. Limitations of previous studies include a lack of exact estimates of HM dose and of generalizability to minority populations. OBJECTIVE: To determine the impact on ND outcome of an exact dose of HM received in the NICU in a diverse, contemporary cohort of VLBW infants. METHODS: We included 430 VLBW infants born in the period 2008-2012 for whom the mean daily dose (DD) of HM received during the stay in the NICU (NICU HM-DD) was calculated prospectively from the daily nutritional intake from admission to discharge...
August 3, 2017: Neonatology
https://www.readbyqxmd.com/read/28768252/amniotic-fluid-concentrations-of-glial-fibrillary-acidic-protein-do-not-correlate-with-prenatal-metrics-in-fetuses-with-myelomeningocele
#13
Aimee G Kim, Enrico Danzer, Julie S Moldenhauer, Nahla Khalek, Lauren E McClain, Lindsay N Waqar, Holly L Hedrick, Mark P Johnson, N Scott Adzick, William H Peranteau, Alan W Flake
INTRODUCTION: We investigated the correlation of amniotic fluid (AF) concentrations of glial fibrillary acidic protein (GFAP) with prenatal features of myelomeningocele (MMC) and neurodevelopmental outcome after fetal MMC (fMMC) surgery. MATERIALS AND METHODS: AF was collected during fMMC surgery between December 2012 and November 2015. AF-GFAP concentration was determined by ELISA. Retrospective chart review identified the characteristics of the defect. Data regarding delivery and 1-year neurodevelopmental outcome was collected from The Children's Hospital of Philadelphia fMMC Registry...
July 29, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28763424/congenital-cytomegalovirus-infection-after-a-multiple-birth-pregnancy
#14
Einat Shmueli, Eran Hadar, Joseph Pardo, Joseph Attias, Jacob Amir, Efraim Bilavsky
BACKGROUND: Congenital cytomegalovirus (cCMV) infection is an important cause of hearing loss and neurodevelopment delay. While data on vertical transmission and neonatal outcome after singleton pregnancy with cCMV is well established, only scarce reports have addressed cCMV in multiple birth pregnancies. Furthermore, no studies have yet compared the outcome after birth and long-term follow up of children with cCMV born after a singleton vs. multiple pregnancy. METHODS: Infant outcome after birth of symptomatic vs...
July 31, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28759667/early-life-epilepsies-and-the-emerging-role-of-genetic-testing
#15
Anne T Berg, Jason Coryell, Russell P Saneto, Zachary M Grinspan, John J Alexander, Mariana Kekis, Joseph E Sullivan, Elaine C Wirrell, Renée A Shellhaas, John R Mytinger, William D Gaillard, Eric H Kossoff, Ignacio Valencia, Kelly G Knupp, Courtney Wusthoff, Cynthia Keator, William B Dobyns, Nicole Ryan, Tobias Loddenkemper, Catherine J Chu, Edward J Novotny, Sookyong Koh
Importance: Early-life epilepsies are often a consequence of numerous neurodevelopmental disorders, most of which are proving to have genetic origins. The role of genetic testing in the initial evaluation of these epilepsies is not established. Objective: To provide a contemporary account of the patterns of use and diagnostic yield of genetic testing for early-life epilepsies. Design, Setting, and Participants: In this prospective cohort, children with newly diagnosed epilepsy with an onset at less than 3 years of age were recruited from March 1, 2012, to April 30, 2015, from 17 US pediatric hospitals and followed up for 1 year...
July 31, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28759409/head-growth-trajectory-and-neurodevelopmental-outcomes-in-preterm-neonates
#16
Kamini Raghuram, Junmin Yang, Paige T Church, Zenon Cieslak, Anne Synnes, Amit Mukerji, Prakesh S Shah
OBJECTIVES: To evaluate the association between head growth (HG) during neonatal and postdischarge periods and neurodevelopmental outcomes of preterm neonates of <29 weeks gestational age. METHODS: We conducted a retrospective cohort study of infants <29 weeks gestational
age admitted between 2009 and 2011 to participating Canadian Neonatal Network
units and followed by Canadian Neonatal Follow-Up Network clinics. Differences in head circumference (ΔHC) z score were calculated for 3 time periods, which include admission to discharge, discharge to follow-up at 16-36 months, and admission to follow-up...
July 2017: Pediatrics
https://www.readbyqxmd.com/read/28755859/systemic-inflammation-combined-with-neonatal-cerebellar-haemorrhage-aggravates-long-term-structural-and-functional-outcomes-in-a-mouse-model
#17
Sophie Tremblay, Alex Pai, Lindsay Richter, Rod Vafaei, Praneetha Potluri, Jacob Ellegood, Jason P Lerch, Daniel Goldowitz
BACKGROUND: Despite the increased recognition of cerebellar injury in survivors of preterm birth, the neurodevelopmental consequences of isolated cerebellar injury have been largely unexplored and our current understanding of the functional deficits requires further attention in order to translate knowledge to best practices. Preterm infants are exposed to multiple stressors during their postnatal development including perinatal cerebellar haemorrhage (CBH) and postnatal infection, two major risk factors for neurodevelopmental impairments...
July 27, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28754176/genome-wide-gene-by-lead-exposure-interaction-analysis-identifies-unc5d-as-a-candidate-gene-for-neurodevelopment
#18
Zhaoxi Wang, Birgit Claus Henn, Chaolong Wang, Yongyue Wei, Li Su, Ryan Sun, Han Chen, Peter J Wagner, Quan Lu, Xihong Lin, Robert Wright, David Bellinger, Molly Kile, Maitreyi Mazumdar, Martha Maria Tellez-Rojo, Lourdes Schnaas, David C Christiani
BACKGROUND: Neurodevelopment is a complex process involving both genetic and environmental factors. Prenatal exposure to lead (Pb) has been associated with lower performance on neurodevelopmental tests. Adverse neurodevelopmental outcomes are more frequent and/or more severe when toxic exposures interact with genetic susceptibility. METHODS: To explore possible loci associated with increased susceptibility to prenatal Pb exposure, we performed a genome-wide gene-environment interaction study (GWIS) in young children from Mexico (n = 390) and Bangladesh (n = 497)...
July 28, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28752797/the-bird-dancer-and-the-warrior-king-divergent-lived-experiences-of-tourette-syndrome-in-bali
#19
Robert Lemelson, Annie Tucker
In the past two decades, ethnographic, epidemiological and interdisciplinary research has robustly established that culture is significant in determining the long-term outcomes of people with neurodevelopmental, neuropsychiatric and mood disorders. Yet these cultural factors are certainly not uniform across discrete individual experiences. Thus, in addition to illustrating meaningful differences for people with neuropsychiatric disorder between different cultures, ethnography should also help detail the variations within a culture...
January 1, 2017: Transcultural Psychiatry
https://www.readbyqxmd.com/read/28751857/the-bdnf-val-66-met-polymorphism-affects-neuronal-morphology-and-synaptic-transmission-in-cultured-hippocampal-neurons-from-rett-syndrome-mice
#20
Xin Xu, Jordi Garcia, Rachel Ewalt, Shelly Nason, Lucas Pozzo-Miller
Brain-derived neurotrophic factor (Bdnf) has been implicated in several neurological disorders including Rett syndrome (RTT), an X-linked neurodevelopmental disorder caused by loss-of-function mutations in the transcriptional modulator methyl-CpG-binding protein 2 (MECP2). The human BDNF gene has a single nucleotide polymorphism (SNP)-a methionine (met) substitution for valine (val) at codon 66-that affects BDNF's trafficking and activity-dependent release and results in cognitive dysfunction. Humans that are carriers of the met-BDNF allele have subclinical memory deficits and reduced hippocampal volume and activation...
2017: Frontiers in Cellular Neuroscience
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