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Neuromuscular stimulation

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https://www.readbyqxmd.com/read/28941526/pediatric-myasthenia-gravis
#1
Jason H Peragallo
Myasthenia gravis is a disorder of neuromuscular transmission that leads to fatigue of skeletal muscles and fluctuating weakness. Myasthenia that affects children can be classified into the following 3 forms: transient neonatal myasthenia, congenital myasthenic syndromes, and juvenile myasthenia gravis (JMG). JMG is an autoimmune disorder that has a tendency to affect the extraocular muscles, but can also affect all skeletal muscles leading to generalized weakness and fatigability. Respiratory muscles may be involved leading to respiratory failure requiring ventilator support...
May 2017: Seminars in Pediatric Neurology
https://www.readbyqxmd.com/read/28937031/a-novel-agrn-mutation-leads-to-congenital-myasthenic-syndrome-only-affecting-limb-girdle-muscle
#2
Ying Zhang, Yi Dai, Jing-Na Han, Zhao-Hui Chen, Li Ling, Chuan-Qiang Pu, Li-Ying Cui, Xu-Sheng Huang
BACKGROUND: Congenital myasthenic syndromes (CMSs) are a group of clinically and genetically heterogeneous disorders caused by impaired neuromuscular transmission. The defect of AGRN was one of the causes of CMS through influencing the development and maintenance of neuromuscular transmission. However, CMS reports about this gene mutation were rare. Here, we report a novel homozygous missense mutation (c.5302G>C) of AGRN in a Chinese CMS pedigree. METHODS: We performed a detailed clinical assessment of a Chinese family with three affected members...
October 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28935232/utilising-physiological-principles-of-motor-unit-recruitment-to-reduce-fatigability-of-electrically-evoked-contractions-a-narrative-review
#3
Trevor S Barss, Emily N Ainsley, Francisca C Claveria-Gonzalez, M John Luu, Dylan J Miller, Matheus J Wiest, David F Collins
Neuromuscular electrical stimulation (NMES) is used to produce contractions to restore movement and reduce secondary complications for individuals experiencing motor impairment. NMES is conventionally delivered through a single pair of electrodes over a muscle belly or nerve trunk using short pulse durations and frequencies between 20-40 Hz (conventional NMES). Unfortunately, the benefits and widespread use of conventional NMES are limited by contraction fatigability, which is due in large part to the non-physiological way that contractions are generated...
September 18, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28930862/an-innovative-ergometer-to-measure-neuromuscular-fatigue-immediately-after-cycling
#4
Douglas Doyle-Baker, John Temesi, Mary E Medysky, Robert J Holash, Guillaume Y Millet
PURPOSE: When assessing neuromuscular fatigue (NMF) from dynamic exercise using large muscle mass (e.g. cycling), most studies have delayed measurement for 1-3 min after task failure. This study aimed to determine the reliability of an innovative cycling ergometer permitting the start of fatigue measurement within 1 s after cycling. METHODS: Twelve subjects participated in two experimental sessions. Knee-extensor NMF was assessed by electrical nerve and transcranial magnetic stimulation with both a traditional chair set-up (PRE and POST-Chair, 2 min post-exercise) and the new cycling ergometer (PRE, every 3 min during incremental exercise and POST-Bike, at task failure)...
September 19, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28928706/early-stroke-rehabilitation-of-the-upper-limb-assisted-with-an-electromyography-driven-neuromuscular-electrical-stimulation-robotic-arm
#5
Qiuyang Qian, Xiaoling Hu, Qian Lai, Stephanie C Ng, Yongping Zheng, Waisang Poon
BACKGROUND: Effective poststroke motor rehabilitation depends on repeated limb practice with voluntary efforts. An electromyography (EMG)-driven neuromuscular electrical stimulation (NMES)-robot arm was designed for the multi-joint physical training on the elbow, the wrist, and the fingers. OBJECTIVES: To investigate the training effects of the device-assisted approach on subacute stroke patients and to compare the effects with those achieved by the traditional physical treatments...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28905003/an-immediate-effect-of-pnf-specific-mobilization-on-the-angle-of-trunk-rotation-and-the-trunk-pelvis-hip-angle-range-of-motion-in-adolescent-girls-with-double-idiopathic-scoliosis-a-pilot-study
#6
A Stępień, K Fabian, K Graff, M Podgurniak, A Wit
BACKGROUND: Impairment of spine rotation is a key concept in several theories explaining the pathogenesis and progression of scoliosis. In previous studies, a more limited range of motion in scoliotic girls compared to their non-scoliotic peers was noted. The Trunk-Pelvis-Hip Angle measurement is a test used to assess the range of motion in the trunk-pelvis-hip complex in the transverse plane. The aim of this study was to assess an immediate effect of Proprioceptive Neuromuscular Facilitation specific mobilization (mPNF) on the angle of trunk rotation and Trunk-Pelvis-Hip Angle range of motion in adolescent girls with double scoliosis...
2017: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/28900719/the-effects-of-exercise-induced-muscle-damage-on-critical-torque
#7
Marcin K Szczyglowski, Carl J Ade, Jason A Campbell, Christopher D Black
OBJECTIVE: Exercise-induced muscle damage (EIMD) has been shown to reduce endurance exercise performance. This study examined the effects of EIMD on critical torque (CT) and the sum of the torque integral above CT during (∫ T total) during a 5-min all-out, intermittent isometric knee extension exercise. METHODS: CT was determined in eight participants prior to and 48-h following EIMD. EIMD was induced using electrically stimulated eccentric knee extensions until maximal voluntary strength (MVC) was reduced by 40%...
September 12, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28900414/alterations-in-spectral-attributes-of-surface-electromyograms-after-utilization-of-a-foot-drop-stimulator-during-post-stroke-gait
#8
Rakesh Pilkar, Arvind Ramanujam, Karen J Nolan
BACKGROUND: A foot drop stimulator (FDS) is a rehabilitation intervention that stimulates the common peroneal nerve to facilitate ankle dorsiflexion at the appropriate time during post-stroke hemiplegic gait. Time-frequency analysis (TFA) of non-stationary surface electromyograms (EMG) and spectral variables such as instantaneous mean frequency (IMNF) can provide valuable information on the long-term effects of FDS intervention in terms of changes in the motor unit (MU) recruitment during gait, secondary to improved dorsiflexion...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28894267/optogenetic-approach-for-targeted-activation-of-global-calcium-transients-in-differentiated-c2c12-myotubes
#9
Stéphane Sebille, Oualid Ayad, Charles-Albert Chapotte-Baldacci, Christian Cognard, Patrick Bois, Aurélien Chatelier
Excitation-contraction coupling in muscle cells is initiated by a restricted membrane depolarization delimited within the neuromuscular junction. This targeted depolarization triggers an action potential that propagates and induces a global cellular calcium response and a consequent contraction. To date, numerous studies have investigated this excitation-calcium response coupling by using different techniques to depolarize muscle cells. However, none of these techniques mimic the temporal and spatial resolution of membrane depolarization observed in the neuromuscular junction...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28890686/synaptic-activity-and-muscle-contraction-increases-pdk1-and-pkc%C3%AE-i-phosphorylation-in-the-presynaptic-membrane-of-the-neuromuscular-junction
#10
Erica Hurtado, Víctor Cilleros, Laia Just, Anna Simó, Laura Nadal, Marta Tomàs, Neus Garcia, Maria A Lanuza, Josep Tomàs
Conventional protein kinase C βI (cPKCβI) is a conventional protein kinase C (PKC) isoform directly involved in the regulation of neurotransmitter release in the neuromuscular junction (NMJ). It is located exclusively at the nerve terminal and both synaptic activity and muscle contraction modulate its protein levels and phosphorylation. cPKCβI molecular maturation includes a series of phosphorylation steps, the first of which is mediated by phosphoinositide-dependent kinase 1 (PDK1). Here, we sought to localize PDK1 in the NMJ and investigate the hypothesis that synaptic activity and muscle contraction regulate in parallel PDK1 and cPKCβI phosphorylation in the membrane fraction...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28885365/therapeutic-efficacy-of-neuromuscular-electrical-stimulation-and-electromyographic-biofeedback-on-alzheimer-s-disease-patients-with-dysphagia
#11
Yi Tang, Xiang Lin, Xiao-Juan Lin, Wei Zheng, Zhi-Kai Zheng, Zhao-Min Lin, Jian-Hao Chen
To study the therapeutic effect of neuromuscular electrical stimulation and electromyographic biofeedback (EMG-biofeedback) therapy in improving swallowing function of Alzheimer's disease patients with dysphagia.A series of 103 Alzheimer's disease patients with dysphagia were divided into 2 groups, among which the control group (n = 50) received swallowing function training and the treatment group (n = 53) received neuromuscular electrical stimulation plus EMG-biofeedback therapy. The mini-mental state scale score was performed in all patients along the treatment period...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28883745/review-of-devices-used-in-neuromuscular-electrical-stimulation-for-stroke-rehabilitation
#12
REVIEW
Kotaro Takeda, Genichi Tanino, Hiroyuki Miyasaka
Neuromuscular electrical stimulation (NMES), specifically functional electrical stimulation (FES) that compensates for voluntary motion, and therapeutic electrical stimulation (TES) aimed at muscle strengthening and recovery from paralysis are widely used in stroke rehabilitation. The electrical stimulation of muscle contraction should be synchronized with intended motion to restore paralysis. Therefore, NMES devices, which monitor electromyogram (EMG) or electroencephalogram (EEG) changes with motor intention and use them as a trigger, have been developed...
2017: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/28883534/biological-effects-of-dosing-aerobic-exercise-and-neuromuscular-electrical-stimulation-in-rats
#13
Stefania Dalise, Loredana Cavalli, Harmanvir Ghuman, Brendon Wahlberg, Madeline Gerwig, Carmelo Chisari, Fabrisia Ambrosio, Michel Modo
Aerobic exercise (AE) and non-aerobic neuromuscular electric stimulation (NMES) are common interventions used in physical therapy. We explored the dose-dependency (low, medium, high) of these interventions on biochemical factors, such as brain derived neurotrophic growth factor (BDNF), vascular endothelial growth factor-A (VEGF-A), insulin-like growth factor-1 (IGF-1) and Klotho, in the blood and brain of normal rats, as well as a treadmill-based maximum capacity test (MCT). A medium dose of AE produced the most improvement in MCT with dose-dependent changes in Klotho in the blood...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28879576/effects-of-acute-resistance-training-modality-on-corticospinal-excitability-intra-cortical-and-neuromuscular-responses
#14
Christopher Latella, Wei-Peng Teo, Dale Harris, Brendan Major, Dan VanderWesthuizen, Ashlee M Hendy
OBJECTIVE: Although neural adaptations from strength training are known to occur, the acute responses associated with heavy-strength (HST) and hypertrophy training (HYT) remain unclear. Therefore, we aimed to compare the acute behaviour of corticospinal responses following a single session of HST vs HYT over a 72-h period. METHODS: Fourteen participants completed a random counterbalanced, crossover study that consisted of a single HST session [5 sets × 3 repetition maximum (RM)], a HYT session (3 sets × 12 RM) of the leg extensors and a control session (CON)...
September 6, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28874063/venous-thromboprophylaxis-with-neuromuscular-stimulation-is-it-calf-muscle-pumping-or-just-twitches-and-jerks
#15
Christopher R Lattimer, Vassilios Zymvragoudakis, George Geroulakos, Evi Kalodiki
The common peroneal nerve stimulator (CPNS) is a UK-approved device for reducing venous thromboembolism risk. It resembles a wrist watch and is placed over the common peroneal nerve to fire at 1 electrical impulse/sec. The aim was to quantify the claim that it drives the venous muscle pump and imitates walking. Twelve healthy volunteers performed 10 tip-toe maneuvers and 10 ankle dorsiflexions to imitate walking movements. The reductions in calf volume were recorded using air plethysmography (APG). The common peroneal nerve was stimulated for over 10 seconds at each of the 7 increasing electrical impulse settings, and the volume reductions were measured for comparison...
January 1, 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28873252/carbonic-anhydrase-inhibitor-acetazolamide-shifts-synaptic-vesicle-recycling-to-a-fast-mode-at-the-mouse-neuromuscular-junction
#16
Nicolas Ivan Bertone, Ayelén Ivana Groisman, Graciela Lujan Mazzone, Raquel Cano, Lucia Tabares, Osvaldo Daniel Uchitel
Acetazolamide (AZ), a molecule frequently used to treat different neurological syndromes, is an inhibitor of the carbonic anhydrase (CA), an enzyme that regulates pH inside and outside cells. We combined fluorescent FM styryl dyes and electrophysiological techniques at ex vivo levator auris longus neuromuscular junctions (NMJs) from mice to investigate the modulation of synaptic transmission and vesicle recycling by AZ. Transmitter release was minimally affected by AZ, as evidenced by evoked and spontaneous end-plate potential measurements...
September 5, 2017: Synapse
https://www.readbyqxmd.com/read/28869434/effects-of-neuromuscular-electrical-stimulation-and-kinesio-taping-applications-in-children-with-cerebral-palsy-on-postural-control-and-sitting-balance
#17
Bülent Elbasan, Kamile Uzun Akkaya, Mufit Akyüz, Deran Oskay
BACKGROUND: Neurodevelopmental treatment (NDT), neuromuscular electrical stimulation (NMES), and Kinesio Taping (KT) applications are separately used to improve postural control and sitting balance in children with cerebral palsy (CP). OBJECTIVE: The aim of this study is to examine the combined effect of NDT, NMES and KT applications on postural control and sitting balance in children with CP. METHODS: Forty five children, in 3 groups, between the ages 5-12 years were included in the study...
August 21, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28869034/plasticity-and-function-of-human-skeletal-muscle-in-relation-to-disuse-and-rehabilitation-influence-of-ageing-and-surgery
#18
Charlotte Suetta
In order to study the influence of disuse and aging on skeletal muscle homeostasis, different human models were employed. Effects of chronic disuse were investigated in elderly patients suffering from uni-lateral hip-osteoarthritis, whereas the effect of short-term disuse (4 and 14 days of unilateral lower limb immobilisation) was assessed in healthy young and old individuals. In summary, chronic muscle disuse in the elderly was associated with marked quantitative as well as qualitative neuromuscular impairments...
August 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28863931/diabetes-mellitus-does-not-affect-the-neuromuscular-blocking-action-of-atracurium-in-dogs
#19
Elizabeth A Leece, Louise Clark
OBJECTIVE: To compare the duration of action of atracurium in diabetic and nondiabetic dogs. STUDY DESIGN: Prospective, blinded, clinical study. ANIMALS: A total of 26 diabetic and 29 nondiabetic dogs. METHODS: Following preanaesthetic medication and intravenous (IV) propofol induction, anaesthesia was maintained with isoflurane in oxygen. Atracurium 0.2 mg kg(-1) IV was administered to provide neuromuscular blockade (NMB) and the responses (twitches; T) to train-of-four nerve stimulation were recorded by palpation and electromyography (EMG)...
April 25, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28862761/effects-of-pulse-duration-on-muscle-fatigue-during-electrical-stimulation-inducing-moderate-level-contraction
#20
Woohyoung Jeon, Lisa Griffin
INTRODUCTION: Neuromuscular electrical stimulation (NMES) is used to prevent muscle atrophy. However, the effect of pulse duration modulation for reducing muscle fatigue and pain is unknown. METHODS: Two 2-minute stimulation protocols were applied to the knee extensors of 10 healthy individuals. In one session, a long pulse duration (1,000 μs) and a low current amplitude (LL) set to evoke 25% maximal voluntary contraction at 30 Hz were applied. The other session was identical except that a short pulse duration (200 μs) and a high current amplitude (SH) were used...
September 1, 2017: Muscle & Nerve
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