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Neuromuscular stimulation

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https://www.readbyqxmd.com/read/28544784/presynaptic-congenital-myasthenic-syndrome-with-a-homozygous-sequence-variant-in-lama5-combines-myopia-facial-tics-and-failure-of-neuromuscular-transmission
#1
Ricardo A Maselli, Juan Arredondo, Jessica Vázquez, Jessica X Chong, Michael J Bamshad, Deborah A Nickerson, Marian Lara, Fiona Ng, Victoria L Lo, Peter Pytel, Craig M McDonald
Defects in genes encoding the isoforms of the laminin alpha subunit have been linked to various phenotypic manifestations, including brain malformations, muscular dystrophy, ocular defects, cardiomyopathy, and skin abnormalities. We report here a severe defect of neuromuscular transmission in a consanguineous patient with a homozygous variant in the laminin alpha-5 subunit gene (LAMA5). The variant c.8046C>T (p.Arg2659Trp) is rare and has a predicted deleterious effect. The affected individual, who also carries a rare homozygous sequence variant in LAMA1, had muscle weakness, myopia, and facial tics...
May 25, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28541915/embedded-system-for-prosthetic-control-using-implanted-neuromuscular-interfaces-accessed-via-an-osseointegrated-implant
#2
Enzo Mastinu, Pascal Doguet, Yohan Botquin, Bo Hakansson, Max Ortiz-Catalan
Despite the technological progress in robotics achieved in the last decades, prosthetic limbs still lack functionality, reliability, and comfort. Recently, an implanted neuromusculoskeletal interface built upon osseointegration was developed and tested in humans, namely the Osseointegrated Human-Machine Gateway. Here, we present an embedded system to exploit the advantages of this technology. Our artificial limb controller allows for bioelectric signals acquisition, processing, decoding of motor intent, prosthetic control, and sensory feedback...
May 23, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28539869/correct-the-smile-of-a-child-by-neuromuscular-facilitation-technique-an-interesting-case-report
#3
Vencita Priyanka Aranha, Asir John Samuel, Kanimozhi Narkeesh
Bell's palsy (BP) in children is a rare case with no documented evidence regarding its rehabilitation management. Till date, individuals with BP are being treated with electrical stimulation are proportionately greater than other conventional means such as facial exercise and massage. These conventional modes of treatment have proved to have less incidence of synkinesis with more benefits. Here, we report a case of a 7-year-old boy diagnosed clinically to have right idiopathic facial nerve paralysis, who underwent 14 days of facial proprioceptive neuromuscular facilitation exercises along with facial therapeutic massage...
April 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/28539692/results-of-physiotherapy-treatments-in-exacerbations-of-chronic-obstructive-pulmonary-disease-a-systematic-review
#4
Irene Torres-Sánchez, Roberto Cruz-Ramírez, Irene Cabrera-Martos, Ana Díaz-Pelegrina, Marie Carmen Valenza
Purpose: The objective of this study was to review clinical trials of the effectiveness of physiotherapy compared with standard care, focused mainly on the functional status of patients hospitalized for acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: Search strategies were developed for each of the databases (PubMed, Scopus, and Web of Science). The study eligibility criteria were as follows: (1) The objective was to assess the effect and efficacy of physiotherapy compared with standard care (which included only medical and pharmacological treatment); (2) adults subjects had AECOPD; (3) one of the outcome measures was functional status, defined as an individual's ability to perform the normal daily activities required to meet basic needs, fulfill usual roles, and maintain health and well-being; (4) it was a clinical trial; (5) it was written in English; (6) it was published between January 2009 and February 2016; and (7) the full-text article was available...
2017: Physiotherapy Canada. Physiothérapie Canada
https://www.readbyqxmd.com/read/28539391/reevaluation-of-reflex-responses-of-the-human-masseter-muscle-to-electrical-lip-stimulation
#5
Paulius Uginčius, Gizem Yilmaz, Oguz Sebik, Kemal Sitki Turker
We examined the reflex response of the human masseter muscle to electrical stimulation of the lip using both single motor unit and surface electromyogram based methods. Using the classical analysis methods, reflex response to mild electrical stimuli generated two distinct short-lasting inhibitions. This pattern may reflect the development of combinations of short and long latency inhibitory postsynaptic potentials as a result of the mildly painful electrical lip stimulation. However, this pattern appearing in the classical analysis methods may have developed as a consequence of earlier responses and may not be genuine...
May 24, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28536859/accelerated-life-test-methods-and-results-for-implantable-electronic-devices-with-adhesive-encapsulation
#6
Xuechen Huang, Petcharat May Denprasert, Li Zhou, Adriana Nicholson Vest, Sam Kohan, Gerald E Loeb
We have developed and applied new methods to estimate the functional life of miniature, implantable, wireless electronic devices that rely on non-hermetic, adhesive encapsulants such as epoxy. A comb pattern board with a high density of interdigitated electrodes (IDE) could be used to detect incipient failure from water vapor condensation. Inductive coupling of an RF magnetic field was used to provide DC bias and to detect deterioration of an encapsulated comb pattern. Diodes in the implant converted part of the received energy into DC bias on the comb pattern...
September 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28534754/the-icvsie-a-general-purpose-integral-equation-method-for-bio-electromagnetic-analysis
#7
Luis J Gomez, Abdulkadir C Yucel, Eric Michielssen
An internally combined volume surface integral equation (ICVSIE) for analyzing electromagnetic (EM) interactions with biological tissue and wide ranging diagnostic, therapeutic, and research applications, is proposed. METHOD: The ICVSIE is a system of integral equations in terms of volume and surface equivalent currents in biological tissue subject to fields produced by externally or internally positioned devices. The system is created by using equivalence principles and solved numerically; the resulting current values are used to evaluate scattered and total electric fields, specific absorption rates, and related quantities...
May 16, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28527228/efficacy-of-neuromuscular-electrical-stimulation-for-preventing-quadriceps-muscle-wasting-in-patients-with-moderate-or-severe-acute-stroke-a-pilot-study
#8
Masafumi Nozoe, Masashi Kanai, Hiroki Kubo, Yuka Takeuchi, Miki Kobayashi, Miho Yamamoto, Asami Furuichi, Makoto Yamazaki, Shinichi Shimada, Kyoshi Mase
BACKGROUND: Stroke-related muscle wasting is one of the factors leading to long-term disability and functional dependency. No study has reported an effective therapeutic intervention for such muscle wasting. OBJECTIVE: The purpose of this study was to investigate the effects of neuromuscular electrical stimulation (NMES) on quadriceps muscle mass preservation in patients with acute moderate or severe stroke by using ultrasonography (US). METHODS: Twenty patients with acute, moderate, or severe stroke (age: 68±11 years) were divided into usual care group (control group) and intervention groups (NMES group), respectively...
May 19, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28513326/the-effects-of-blood-flow-restricted-electrostimulation-on-strength-hypertrophy
#9
Joshua Slysz, Jamie F Burr
CONTEXT: The combined effect of neuromuscular electrical muscle stimulation (NMES) and blood flow restriction (BFR) on muscle mass and strength has not been thoroughly investigated. OBJECTIVE: To examine the effects of combined and independent BFR and a low-intensity NMES on skeletal muscle adaptation. DESIGN: Exploratory Study. SETTING: Laboratory. PARTICIPANTS: Twenty recreationally active subjects...
May 17, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28507531/noradrenergic-activation-of-hypoglossal-nucleus-modulates-the-central-regulation-of-genioglossus-in-chronic-intermittent-hypoxic-rats
#10
Xinshi Nie, Ling Zhou, Aidi Wang, Hongyu Jin, Zheng Qin, Jian Pang, Wei Wang, Jian Kang
Neuromuscular compensation of the genioglossus muscle can be induced by chronic intermittent hypoxia (CIH) in obstructive sleep apnea to maintain upper airway stability. Noradrenergic activation of hypoglossal nucleus plays a critical role in the central control of the genioglossus. However, it remains unknown whether norepinephrine takes part in the central regulation of the genioglossus during CIH. Adult male Wistar rats (n = 32) were studied to explore the influence of noradrenergic activation of hypoglossal nucleus on the central control of the genioglossus at different stages of CIH...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28506261/a-possible-role-of-low-regulatory-t-cells-in-anti-acetylcholine-receptor-antibody-positive-myasthenia-gravis-after-bone-marrow-transplantation
#11
Masahiko Fukatsu, Takenobu Murakami, Hiroshi Ohkawara, Shunichi Saito, Kazuhiko Ikeda, Suguru Kadowaki, Itaru Sasaki, Mari Segawa, Tomoko Soeda, Akihiko Hoshi, Hiroshi Takahashi, Akiko Shichishima-Nakamura, Kazuei Ogawa, Yoshihiro Sugiura, Hitoshi Ohto, Yasuchika Takeishi, Takayuki Ikezoe, Yoshikazu Ugawa
BACKGROUND: Chronic graft-versus-host disease (GVHD) appears several months following allogenic hematopoietic stem cell transplantation (HSCT) and is clinically analogous to autoimmune disorder. Polymyositis is a common neuromuscular disorder in chronic GVHD, but myasthenia gravis (MG) is extremely rare. Hence, its pathophysiology and treatment have not been elucidated. CASE PRESENTATION: A 63-year-old man with a history of chronic GVHD presented with ptosis, dropped head, and dyspnea on exertion, which had worsened over the previous several months...
May 15, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28495848/physical-activity-modulates-corticospinal-excitability-of-the-lower-limb-in-young-and-old-adults
#12
Hamidollah Hassanlouei, Christopher W Sundberg, Ashleigh Elizabeth Smith, Andrew Kuplic, Sandra K Hunter
Aging is associated with reduced neuromuscular function, which may be due in part to altered corticospinal excitability. Regular physical activity (PA) may ameliorate these age-related declines, but the influence of PA on corticospinal excitability is unknown. The purpose of this study was to determine the influence of age, sex and PA on corticospinal excitability by comparing the stimulus-response curves of motor evoked potentials (MEP) in 28 young (22.4±2.2 yrs, 14 women, 14 men) and 50 old adults (70.2±6...
May 11, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28495800/mechanically-patterned-neuromuscular-junctions-in-a-dish-have-improved-functional-maturation
#13
Cassandra L Happe, Kevin P Tenerelli, Anastasia K Gromova, Frederic Kolb, Adam J Engler
Motor neuron (MN) diseases are progressive disorders resulting from degeneration of neuromuscular junctions (NMJs), which form the connection between MNs and muscle fibers. NMJ-in-a-dish models have been developed to examine human MN-associated dysfunction with disease; however such co-culture models have randomly oriented myotubes with immature synapses that contract asynchronously. Mechanically patterned (MP) extracellular matrix with alternating soft and stiff stripes improve current NMJ-in-a-dish models by inducing both mouse and human myoblast durotaxis to stripes where they aligned, differentiated, and fused into patterned myotubes...
May 11, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28489210/sugammadex-ed90-dose-to-reverse-the-rocuronium-neuromuscular-blockade-in-obese-patients
#14
Mauro Prado DA Silva, Christiano Matsui, Daniel Dongiou Kim, Joaquim Edson Vieira, Carlos Alberto Malheiros, Ligia Andrade Silva Telles Mathias
Objective: to determine the ED90 (minimum effective dose in 90% of patients) of sugammadex for the reversal of rocuronium-induced moderate neuromuscular blockade (NMB) in patients with grade III obesity undergoing bariatric surgery. Methods: we conducted a prospective study with the biased coin up-and-down sequential design. We chosen the following doses: 2.0mg/Kg, 2.2mg/Kg, 2.4mg/Kg, 2.6mg/Kg, 2.8mg/Kg. The complete reversal of rocuronium-induced NMB considered a T4/T1 ratio ≥0...
January 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28485493/regionalization-of-the-stretch-reflex-in-the-human-vastus-medialis
#15
Alessio Gallina, Jean-Sébastien Blouin, Tanya D Ivanova, S Jayne Garland
The localization of motor unit territories provides an anatomical basis to suggest that the CNS may have more independence in motor unit recruitment and control strategies than what was previously thought. In this study, we investigated whether the human spinal cord has the neuromuscular circuitry to independently activate motor units located in different regions of the vastus medialis. Mechanical taps were applied to multiple locations in the vastus medialis (VM) in nine healthy individuals. Regional responses within the muscle were observed using a grid of 5 × 13 surface EMG electrodes...
May 9, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28482746/neuromuscular-electrical-stimulation-combined-with-protein-ingestion-preserves-thigh-muscle-mass-but-not-muscle-function-in-healthy-older-adults-during-5-days-of-bed-rest
#16
Paul Reidy, Alec McKenzie, Preston Brunker, Daniel Nelson, Katherine Barrows, Mark Supiano, Paul LaStayo, Micah Drummond
Short-term bed rest in older adults is characterized by significant loss in leg lean mass and strength posing significant health consequences. The purpose of this study was to determine in healthy older adults if the daily combination of neuromuscular electrical stimulation and protein supplementation (NMES+PRO) would protect muscle mass and function after 5-days of bed rest. Twenty healthy older adults (~70y) were subjected to 5-days of continuous bed rest and were randomized into one of two groups: NMES+PRO (n=10) or CON (n=10)...
May 8, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28480963/use-of-stimulated-electromyography-in-the-analysis-of-the-neuromuscular-junction-in-children
#17
REVIEW
Matthew C Pitt
A screening test is required to diagnose disorders of the neuromuscular junction (NMJ) in children. This Review describes the development of stimulation potential analysis with concentric needle electrodes (SPACE). This nomenclature was chosen to distinguish the technique from single-fiber methodology because of the difficulties in identifying single-fiber potentials in most studies, particularly those with the most severe abnormalities of the NMJ. Performed on orbicularis oculi in children with proven or probable disorders of the NMJ, it demonstrated a sensitivity of 84%, specificity of 71%, negative predictive value of 95%, and positive predictive value of 36%...
May 8, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28478993/exercise-training-versus-neuromuscular-stimulation-in-severe-chronic-obstructive-pulmonary-disease
#18
Matthew Maddocks, Veronica Delogu, Sarah E Jones, Michael I Polkey, William D-C Man
No abstract text is available yet for this article.
May 4, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/28464800/effect-of-tendon-vibration-during-wide-pulse-neuromuscular-electrical-stimulation-nmes-on-the-decline-and-recovery-of-muscle-force
#19
Vanesa Bochkezanian, Robert U Newton, Gabriel S Trajano, Amilton Vieira, Timothy S Pulverenti, Anthony J Blazevich
BACKGROUND: Neuromuscular electrical stimulation (NMES) is commonly used to activate skeletal muscles and reverse muscle atrophy in clinical populations. Clinical recommendations for NMES suggest the use of short pulse widths (100-200 μs) and low-to-moderate pulse frequencies (30-50 Hz). However, this type of NMES causes rapid muscle fatigue due to the (non-physiological) high stimulation intensities and non-orderly recruitment of motor units. The use of both wide pulse widths (1000 μs) and tendon vibration might optimize motor unit activation through spinal reflex pathways and thus delay the onset of muscle fatigue, increasing muscle force and mass...
May 2, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28460690/pain-catastrophizing-moderates-changes-in-spinal-control-in-response-to-noxiously-induced-low-back-pain
#20
Gwyneth B Ross, Peter J Sheahan, Brian Mahoney, Brendon J Gurd, Paul W Hodges, Ryan B Graham
It is generally accepted that spine control and stability are relevant for the prevention and rehabilitation of low back pain (LBP). However, there are conflicting results in the literature in regards to how these variables are modified in the presence of LBP. The aims of the present work were twofold: (1) to use noxious stimulation to induce LBP in healthy individuals to assess the direct effects of pain on control (quantified by the time-dependent behavior of kinematic variance), and (2) to assess whether the relationship between pain and control is moderated by psychological features (i...
April 19, 2017: Journal of Biomechanics
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