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Neuromuscular stimulation

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https://www.readbyqxmd.com/read/29128986/longitudinal-neurophysiological-assessment-of-intramuscular-type-a-botulin-toxin-in-healthy-humans
#1
L Lispi, L Leonardi, A Petrucci
The aim of this study is to assess the neurophysiological abnormalities of type A botulin toxin-infiltrated human muscle, and their evolution over time. Seried cMAP measurements, 3 and 20 Hz repetitive nerve stimulation, EMG, SFEMG over 3 months from toxin injection. Our findings consist in lack of decrement with 3 Hz repetitive nerve stimulation and facilitation with 20 Hz repetitive nerve stimulation; progressive increasing of jitter; early appearance of fibrillations; small and short motor unit action potential in the first 3 weeks, followed by increasing of MUAP amplitude and duration, with polyphasic morphology...
November 11, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29126338/effect-of-neuromuscular-electrical-stimulation-on-brain-derived-neurotrophic-factor
#2
Toshiaki Miyamoto, Keihou Kou, Hideya Yanamoto, Saya Hashimoto, Mai Ikawa, Takashi Sekiyama, Yoshiki Nakano, Shin-Ichiro Kashiwamura, Chisako Takeda, Hiroyuki Fujioka
Brain-derived neurotrophic factor (BDNF) has been considered an essential mediator responsible for the beneficial effects of physical activity in preventing cognitive impairment. This study aimed at examining the effects of a single bout of neuromuscular electrical stimulation (NMES) on levels of BDNF in the plasma and on cognitive performance in healthy adult men. Thirteen healthy adult men participated in three experimental sessions. The first session was 30 min of NMES to both legs, the second was 30 min of cycling exercise at the intensity of 60% peak oxygen uptake, and the third was 30 min of complete rest...
November 10, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29118959/congenital-myasthenic-syndrome-due-to-dok7-mutations-in-a-family-from-chile
#3
Jorge A Bevilacqua, Marian Lara, Jorge Díaz, Mario Campero, Jessica Vázquez, Ricardo A Maselli
Congenital myasthenic syndromes (CMS) are neuromuscular transmission disorders caused by mutations in genes encoding neuromuscular junction proteins. A 61-year-old female and her older sister showed bilateral ptosis, facial and proximal limb weakness, and scoliosis since childhood. Another female sibling had milder signs, while other family members were asymptomatic. Facial nerve repetitive stimulation in the proband showed decrement of muscle responses. Single fiber EMG revealed increased jitter and blocking...
June 27, 2017: European Journal of Translational Myology
https://www.readbyqxmd.com/read/29118716/etiology-and-recovery-of-neuromuscular-fatigue-following-competitive-soccer-match-play
#4
Callum G Brownstein, Jack P Dent, Paul Parker, Kirsty M Hicks, Glyn Howatson, Stuart Goodall, Kevin Thomas
Aim: Previous research into the etiology of neuromuscular fatigue following competitive soccer match-play has primarily focused on peripheral perturbations, with limited research assessing central nervous system function in the days post-match. The aim of the present study was to examine the contribution and time-course of recovery of central and peripheral factors toward neuromuscular fatigue following competitive soccer match-play. Methods: Sixteen male semi-professional soccer players completed a 90-min soccer match...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29117071/deception-improves-tt-performance-in-well-trained-cyclists-without-augmented-fatigue
#5
Paul Ansdell, Kevin Thomas, Glyn Howatson, Markus Amann, Stuart Goodall
PURPOSE: To investigate the effects of feedback, in the form of a virtual avatar paced at 100 and 102% of baseline performance, on neuromuscular fatigue following a 4 km cycling time trial (TT). We hypothesised that improved cycling performance would occur due to participants exceeding a previously established critical threshold, and experiencing greater neuromuscular fatigue. METHODS: Following familiarisation, ten well-trained cyclists performed a baseline 4 km TT without feedback (BASE), followed by two, 4 km TT where they raced against an avatar (set at 100% [accurate - ACC] and 102% [deception - DEC] of baseline power output), in a randomised and counterbalanced order...
November 7, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29114039/neuronal-activity-drives-fmrp-and-hspg-dependent-matrix-metalloproteinase-function-required-for-rapid-synaptogenesis
#6
Mary L Dear, Jarrod Shilts, Kendal Broadie
Matrix metalloproteinase (MMP) functions modulate synapse formation and activity-dependent plasticity. Aberrant MMP activity is implicated in fragile X syndrome (FXS), a disease caused by the loss of the RNA-binding protein FMRP and characterized by neurological dysfunction and intellectual disability. Gene expression studies in Drosophila suggest that Mmps cooperate with the heparan sulfate proteoglycan (HSPG) glypican co-receptor Dally-like protein (Dlp) to restrict trans-synaptic Wnt signaling and that synaptogenic defects in the fly model of FXS are alleviated by either inhibition of Mmp or genetic reduction of Dlp...
November 7, 2017: Science Signaling
https://www.readbyqxmd.com/read/29111852/emg-triggered-stimulation-post-spinal-cord-injury-a-case-report
#7
Maryam Zoghi, Mary P Galea
BACKGROUND: Mechanical injury in patients with spinal cord injury (SCI) rarely transects the cord completely, even when the injury is classified as complete. These patients can show sub-clinical evidence of spared motor connections, which might be amenable to targeted rehabilitation. Neurophysiological evaluations can complement the clinical evaluation by providing objective data about conduction across the SCI site. CASE DESCRIPTION: A twenty-four year old patient with SCI was admitted to a rehabilitation centre 49 days post traumatic SCI...
November 7, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29110426/functional-near-infrared-spectroscopy-to-probe-sensorimotor-region-activation-during-electrical-stimulation-evoked-movement
#8
Makii Muthalib, Marco Ferrari, Valentina Quaresima, Graham Kerr, Stephane Perrey
This study used non-invasive functional near-infrared spectroscopy (fNIRS) neuroimaging to monitor bilateral sensorimotor region activation during unilateral voluntary (VOL) and neuromuscular electrical stimulation (NMES)-evoked movements. METHODS: In eight healthy male volunteers, fNIRS was used to measure relative changes in oxyhaemoglobin (O2 Hb) and deoxyhaemoglobin (HHb) concentrations from a cortical sensorimotor region of interest in the left (LH) and right (RH) hemispheres during NMES-evoked and VOL wrist extension movements of the right arm...
November 7, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/29104116/putative-roles-of-soluble-trophic-factors-in-facial-nerve-regeneration-target-reinnervation-and-recovery-of-vibrissal-whisking
#9
REVIEW
Habib Bendella, Svenja Rink, Maria Grosheva, Levent Sarikcioglu, Tessa Gordon, Doychin N Angelov
It is well-known that, after nerve transection and surgical repair, misdirected regrowth of regenerating motor axons may occur in three ways. The first way is that the axons enter into endoneurial tubes that they did not previously occupy, regenerate through incorrect fascicles and reinnervate muscles that they did not formerly supply. Consequently the activation of these muscles results in inappropriate movements. The second way is that, in contrast with the precise target-directed pathfinding by elongating motor nerves during embryonic development, several axons rather than a single axon grow out from each transected nerve fiber...
November 8, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29090216/congenital-myasthenic-syndrome-in-a-mixed-breed-dog
#10
Theresa J Blakey, Jennifer R Michaels, Ling T Guo, Amy J Hodshon, G Diane Shelton
A 6-month-old, male, intact mixed breed dog was presented for a 3-month history of progressive generalized weakness. Neurologic examination revealed non-ambulatory tetraparesis, weakness of the head and neck, and decreased withdrawal reflexes in all limbs consistent with a generalized neuromuscular disorder. Electromyography and motor nerve conduction velocity were normal. Repetitive nerve stimulation showed a decremental response of the compound muscle action potential with improvement upon intravenous administration of edrophonium chloride...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29079805/genetic-interaction-of-disc1-and-neurexin-in-the-development-of-fruit-fly-glutamatergic-synapses
#11
Himani Pandey, Katia Bourahmoune, Takato Honda, Ken Honjo, Kazuki Kurita, Tomohito Sato, Akira Sawa, Katsuo Furukubo-Tokunaga
Originally identified at the breakpoint of a (1;11)(q42.1; q14.3) chromosomal translocation in a Scottish family with a wide range of mental disorders, the DISC1 gene has been a focus of intensive investigations as an entry point to study the molecular mechanisms of diverse mental dysfunctions. Perturbations of the DISC1 functions lead to behavioral changes in animal models, which are relevant to psychiatric conditions in patients. In this work, we have expressed the human DISC1 gene in the fruit fly (Drosophila melanogaster) and performed a genetic screening for the mutations of psychiatric risk genes that cause modifications of DISC1 synaptic phenotypes at the neuromuscular junction...
October 27, 2017: NPJ Schizophrenia
https://www.readbyqxmd.com/read/29079458/bilateral-extracephalic-transcranial-direct-current-stimulation-improves-endurance-performance-in-healthy-individuals
#12
L Angius, A R Mauger, J Hopker, A Pascual-Leone, E Santarnecchi, S M Marcora
BACKGROUND: Transcranial direct current stimulation (tDCS) has been used to enhance endurance performance but its precise mechanisms and effects remain unknown. OBJECTIVE: To investigate the effect of bilateral tDCS on neuromuscular function and performance during a cycling time to task failure (TTF) test. METHODS: Twelve participants in randomized order received a placebo tDCS (SHAM) or real tDCS with two cathodes (CATHODAL) or two anodes (ANODAL) over bilateral motor cortices and the opposite electrode pair over the ipsilateral shoulders...
October 5, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29068982/delayed-recovery-of-the-affected-finger-extensors-at-chronic-stage-in-a-stroke-patient-a-case-report
#13
Sung Ho Jang, Han Do Lee
RATIONALE: A 33-year-old male presented with complete weakness of the right extremities due to corona radiata infarct. PATIENT CONCERNS: The main concerns of the patient is recovery of hand function especially related to finger extension. DIAGNOSES: Right corona radiata infarct. INTERVENTIONS: He underwent physical therapy and occupational therapy at the outpatient clinic of the rehabilitation department of the same university hospital until 2 years after onset...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29068628/upper-limb-rehabilitation-robot-powered-by-pams-cooperates-with-fes-arrays-to-realize-reach-to-grasp-trainings
#14
Xikai Tu, Hualin Han, Jian Huang, Jian Li, Chen Su, Xiaobo Jiang, Jiping He
The reach-to-grasp activities play an important role in our daily lives. The developed RUPERT for stroke patients with high stiffness in arm flexor muscles is a low-cost lightweight portable exoskeleton rehabilitation robot whose joints are unidirectionally actuated by pneumatic artificial muscles (PAMs). In order to expand the useful range of RUPERT especially for patients with flaccid paralysis, functional electrical stimulation (FES) is taken to activate paralyzed arm muscles. As both the exoskeleton robot driven by PAMs and the neuromuscular skeletal system under FES possess the highly nonlinear and time-varying characteristics, iterative learning control (ILC) is studied and is taken to control this newly designed hybrid rehabilitation system for reaching trainings...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29065566/upper-limb-rehabilitation-robot-powered-by-pams-cooperates-with-fes-arrays-to-realize-reach-to-grasp-trainings
#15
Xikai Tu, Hualin Han, Jian Huang, Jian Li, Chen Su, Xiaobo Jiang, Jiping He
The reach-to-grasp activities play an important role in our daily lives. The developed RUPERT for stroke patients with high stiffness in arm flexor muscles is a low-cost lightweight portable exoskeleton rehabilitation robot whose joints are unidirectionally actuated by pneumatic artificial muscles (PAMs). In order to expand the useful range of RUPERT especially for patients with flaccid paralysis, functional electrical stimulation (FES) is taken to activate paralyzed arm muscles. As both the exoskeleton robot driven by PAMs and the neuromuscular skeletal system under FES possess the highly nonlinear and time-varying characteristics, iterative learning control (ILC) is studied and is taken to control this newly designed hybrid rehabilitation system for reaching trainings...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29059847/low-intensity-focused-ultrasound-stimulator-using-focal-depth-controller-for-improved-targeting-in-neuromuscular-rehabilitation
#16
Sungjin Oh, Dong Hwee Kim, Inchan Youn
Low-intensity ultrasound can be used for noninvasive neuromuscular stimulation to enhance the recovery of injured peripheral nerves and muscles. In order to improve the stimulation efficiency, focused ultrasound (FUS) with a high energy density should be used. Because the FUS is concentrated at a miniaturized focal area, deliberate targeting with focal depth control is required to achieve the accurate stimulation. In this study, a low-intensity focused ultrasound (LIFU) stimulator with a focal depth controller is presented as an effective ultrasound stimulation system for the neuromuscular rehabilitation...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29059108/neuromuscular-electrical-stimulation-superimposed-on-movement-early-after-acl-surgery
#17
Luciana Labanca, Jacopo Emanuele Rocchi, Luca Laudani, Rita Guitaldi, Alessandro Virgulti, Pier Paolo Mariani, Andrea Macaluso
PURPOSE: Quadriceps weakness and asymmetrical loading of lower limbs are two major issues following anterior cruciate ligament reconstruction (ACLR). The aim of this study was to evaluate the effectiveness of a 6-week training protocol involving neuromuscular electrical stimulations (NMES) of the quadriceps muscle superimposed on repeated sit-to-stand-to-sit exercises (STSTS), as an additional treatment to standard rehabilitation, from the 15th to the 60th day following ACLR. METHODS: Sixty-three ACLR patients were randomly allocated to one of the three treatment groups: NMES superimposed on STSTS (NMES+STSTS), STSTS only, or no additional treatment (NAT) to standard rehabilitation...
October 20, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29046425/carotid-chemoreceptors-tune-breathing-via-multipath-routing-reticular-chain-and-loop-operations-supported-by-parallel-spike-train-correlations
#18
Kendall F Morris, Sarah C Nuding, Lauren S Segers, Kimberly Erin Iceman, Russell O'Connor, Jay B Dean, Mackenzie M Ott, Pierina A Alencar, Dale Shuman, Kofi-Kermit Horton, Thomas E Taylor-Clark, Donald C Bolser, Bruce G Lindsey
We tested the hypothesis that carotid chemoreceptors tune breathing through parallel circuit paths that target distinct elements of an inspiratory neuron chain in the ventral respiratory column (VRC). Microelectrode arrays were used to monitor neuronal spike trains simultaneously in the VRC, peri-nucleus tractus solitarius-medial medulla (p-NTS-MM), the dorsal parafacial region of the lateral tegmental field (FTL-pF), and medullary raphé nuclei together with phrenic nerve activity during selective stimulation of carotid chemoreceptors or transient hypoxia in 19 decerebrate, neuromuscularly-blocked, and artificially ventilated cats...
October 18, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29044455/use-of-an-app-controlled-neuromuscular-electrical-stimulation-system-for-improved-self-management-of-knee-conditions-and-reduced-costs
#19
Morad Chughtai, Nicholas Piuzzi, George Yakubek, Anton Khlopas, Nipun Sodhi, Assem A Sultan, Salahuddin Nasir, Benjamin S T Yates, Anil Bhave, Michael A Mont
Patients suffering from quadriceps muscle weakness secondary to osteoarthritis or after surgeries, such as total knee arthroplasty, appear to benefit from the use of neuromuscular electrical stimulation (NMES), which can improve muscle strength and function, range of motion, exercise capacity, and quality of life. Several modalities exist that deliver this therapy. However, with the ever-increasing demand to improve clinical efficiency and costs, digitalize healthcare, optimize data collection, improve care coordination, and increase patient compliance and engagement, newer devices incorporating technologies that facilitate these demands are emerging...
October 12, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29042299/non-pharmacological-interventions-for-spasticity-in-adults-an-overview-of-systematic-reviews
#20
REVIEW
Fary Khan, Bhasker Amatya, Djamel Bensmail, Alain Yelnik
OBJECTIVES: Spasticity causes significant long-term disability-burden, requiring comprehensive management. This review evaluates evidence from published systematic reviews of clinical trials for effectiveness of non-pharmacological interventions for improved spasticity outcomes. METHODS: Data sources: a literature search was conducted using medical and health science electronic (MEDLINE, EMBASE, CINAHL, PubMed, and the Cochrane Library) databases for published systematic reviews up to 15th June 2017...
October 16, 2017: Annals of Physical and Rehabilitation Medicine
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