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Maren C Podszun, Metta Jakobi, Marc Birringer, Johanna Weiss, Jan Frank
SCOPE: Members of the vitamin E family or their metabolites may induce the xenobiotic transporter P-glycoprotein (P-gp), which can limit the bioavailability of drugs and phytochemicals. This study aimed to investigate if α- and γ-tocopherol, α- and γ-tocotrienol, the long chain metabolite α-tocopherol-13'-COOH, the short chain metabolites α- and γ-carboxyethylhydroxychromanol and plastochromanol-8 activate the pregnane X receptor (PXR) and thereby modulate P-gp expression and/or activity...
October 6, 2016: Molecular Nutrition & Food Research
Alessandro Roncone, Matej Hoffmann, Ugo Pattacini, Luciano Fadiga, Giorgio Metta
This paper investigates a biologically motivated model of peripersonal space through its implementation on a humanoid robot. Guided by the present understanding of the neurophysiology of the fronto-parietal system, we developed a computational model inspired by the receptive fields of polymodal neurons identified, for example, in brain areas F4 and VIP. The experiments on the iCub humanoid robot show that the peripersonal space representation i) can be learned efficiently and in real-time via a simple interaction with the robot, ii) can lead to the generation of behaviors like avoidance and reaching, and iii) can contribute to the understanding the biological principle of motor equivalence...
2016: PloS One
Metta Dülk, Gyöngyi Kudlik, Anna Fekete, Dávid Ernszt, Krisztián Kvell, Judit E Pongrácz, Balázs L Merő, Bálint Szeder, László Radnai, Miklós Geiszt, Dalma E Csécsy, Tamás Kovács, Ferenc Uher, Árpád Lányi, Virag Vas, László Buday
The commitment steps of mesenchymal stromal cells (MSCs) to adipogenic and other lineages have been widely studied but not fully understood. Therefore, it is critical to understand which molecules contribute to the conversion of stem cells into differentiated cells. The scaffold protein Tks4 plays a role in podosome formation, EGFR signaling and ROS production. Dysfunction of Tks4 causes a hereditary disease called Frank-ter Haar syndrome with a variety of defects concerning certain mesenchymal tissues (bone, fat and cartilage) throughout embryogenic and postnatal development...
October 6, 2016: Scientific Reports
J Rolando Aguilar-Calderón, Alejandro J Metta-Magaña, Bruce Noll, Skye Fortier
Two-electron reduction of the Ti(IV) compound ((ket) guan)(Im(Dipp) N)Ti(OTf)2 (3) gives the arene-masked complex ((ket) guan)(η(6) -Im(Dipp) N)Ti (1) in excellent yield. Upon standing in solution, 1 converts to a Ti(IV) metallacycle (4) through dehydrogenation of a pendant isopropyl group. Spectroscopic evidence shows this transformation initially proceeds via the oxidative addition of a C(sp(3) )-H bond and can be reversed upon exposure of 4 to H2 . Interestingly, treatment of 1 with cyclohexene gives cyclohexane and 4 via a titanium-mediated transfer hydrogenation reaction, a process that can be extended to catalytically hydrogenate other unsaturated hydrocarbons under mild conditions...
October 6, 2016: Angewandte Chemie
Metta B Pratt, Joshua S Titlow, Ilan Davis, Amy R Barker, Helen R Dawe, Jordan W Raff, Helio Roque
Cilia are conserved organelles that have important motility, sensory and signalling roles. The transition zone (TZ) at the base of the cilium is crucial for cilia function, and defects in several TZ proteins are associated with human congenital ciliopathies such as nephronophthisis (NPHP) and Meckel-Gruber syndrome (MKS). In several species, MKS and NPHP proteins form separate complexes that cooperate with Cep290 to assemble the TZ, but flies seem to lack core components of the NPHP module. We show that MKS proteins in flies are spatially separated from Cep290 at the TZ, and that flies mutant for individual MKS genes fail to recruit other MKS proteins to the TZ, whereas Cep290 seems to be recruited normally...
October 15, 2016: Journal of Cell Science
Chiara Bartolozzi, Lorenzo Natale, Francesco Nori, Giorgio Metta
No abstract text is available yet for this article.
August 24, 2016: Nature Materials
Metta K Jana, Roberto Cappai, Giuseppe D Ciccotosto
Accumulation of soluble amyloid β (Aβ) oligomers in the brain has been suggested to cause neurodegeneration associated with Alzheimer's disease (AD). Our previous findings showed that the binding of Aβ trimer and tetramer to neurons is significantly correlated with Aβ-induced neuronal cell death. We propose blocking of neuronal binding of these neurotoxic Aβ oligomers as a therapeutic strategy for preventing this disease. To test this, a nontoxic triphenylmethane dye, Brilliant Blue G (BBG), which has been reported to modulate Aβ aggregation and neurotoxicity, was investigated using mouse primary cortical neuronal cultures treated with photoinduced cross-linked toxic Aβ40 oligomers as well as soluble Aβ40 and Aβ42 peptides...
August 17, 2016: ACS Chemical Neuroscience
Hemant K Sharma, Paulina E Gonzalez, Alexander L Craig, Sanchita Chakrabarty, Alejandro Metta-Magaña, Keith H Pannell
Compound Et3 SiOCH2 NMe2 transfers Me2 NCH2 to R2 NH (R2 =Et2 , PhMe, [Cr(η(6) -C6 H5 )(CO)3 ]Me, PhH) to form previously unknown diaminomethanes, Me2 NCH2 NR2 and, in the case of R2 =PhH, the triamine Me2 NCH2 N(Ph)CH2 NMe2 . The diaminomethanes exhibit an unreported disproportionation to a mixture of (R2 N)2 CH2 , (Me2 N)2 CH2 , and Me2 NCH2 NR2 , which can be trapped as their [Mo(CO)4 (diamine)] complexes. Whereas PhMeNCH2 NMe2 is a labile material, the metal-substituted ([(η(6) -C6 H5 )Cr(CO)3 ]MeNCH2 NMe2 is a stable material...
May 23, 2016: Chemistry: a European Journal
Mabel Q H Leow, Sally W C Chan
OBJECTIVE: Our aim was to evaluate caregivers' perceptions of a video, telephone follow-up, and online forum as components of a psychoeducational intervention. METHOD: Qualitative semistructured face-to-face interviews were conducted with 12 participants two weeks post-intervention. The study was conducted from September of 2012 to May of 2015. Family caregivers were recruited from four home hospice organizations (HCA Hospice Care, Metta Hospice, Singapore Cancer Centre, and Agape Methodist Hospice) and the National Cancer Centre outpatient clinic in Singapore...
October 2016: Palliative & Supportive Care
M K Metta, R K Kunaparaju, S Tantravahi
Recombinant therapeutic proteins have changed the face of modern medicine in the present trend and they continue to provide innovative therapies for deadly diseases. This study describes the development of a novel stable expression system for rapid amplification of genes in Chinese Hamster Ovary (CHO) cells. The expression system consists of a host CHO cell line and an expression vector (pUB-PyOri-D-C) which encodes for Polyomavirus (Py) Origin of Replication (PyOri) for amplification of integrated genes in the presence of Py Large T Antigen (PyLT) and Dihydrofolate Reductase (DHFR) selectable marker gene for selection in the presence of Methotrexate (MTX)...
2016: Cellular and Molecular Biology
Channing Yu, Aristotle M Mannan, Griselda Metta Yvone, Kenneth N Ross, Yan-Ling Zhang, Melissa A Marton, Bradley R Taylor, Andrew Crenshaw, Joshua Z Gould, Pablo Tamayo, Barbara A Weir, Aviad Tsherniak, Bang Wong, Levi A Garraway, Alykhan F Shamji, Michelle A Palmer, Michael A Foley, Wendy Winckler, Stuart L Schreiber, Andrew L Kung, Todd R Golub
Hundreds of genetically characterized cell lines are available for the discovery of genotype-specific cancer vulnerabilities. However, screening large numbers of compounds against large numbers of cell lines is currently impractical, and such experiments are often difficult to control. Here we report a method called PRISM that allows pooled screening of mixtures of cancer cell lines by labeling each cell line with 24-nucleotide barcodes. PRISM revealed the expected patterns of cell killing seen in conventional (unpooled) assays...
April 2016: Nature Biotechnology
Vivian S Gainer, Andrew Cagan, Victor M Castro, Stacey Duey, Bhaswati Ghosh, Alyssa P Goodson, Sergey Goryachev, Reeta Metta, Taowei David Wang, Nich Wattanasin, Shawn N Murphy
We have designed a Biobank Portal that lets researchers request Biobank samples and genotypic data, query associated electronic health records, and design and download datasets containing de-identified attributes about consented Biobank subjects. This do-it-yourself functionality puts a wide variety and volume of data at the fingertips of investigators, allowing them to create custom datasets for their clinical and genomic research from complex phenotypic data and quickly obtain corresponding samples and genomic data...
2016: Journal of Personalized Medicine
Paul Frewen, Nicholas Rogers, Les Flodrowski, Ruth Lanius
Trauma and stressor-related disorders, including post-traumatic stress disorder (PTSD) and related comorbid disorders such as anxiety, depression, and dissociative disorders, are difficult to treat. Mindfulness-based clinical interventions have proven efficacy for mental health treatment in face-to-face individual and group modalities, although the feasibility and efficacy of delivering these interventions via the internet has not been evaluated. The present research developed mindfulness and metta-based trauma therapy (MMTT) as an internet resource to support the practice of mindfulness and metta (lovingkindness) meditations for self-regulation and healing from trauma and stressor-related disorders...
2015: Mindfulness
Metta K Jana, Roberto Cappai, Chi L L Pham, Giuseppe D Ciccotosto
Amyloid beta (Aβ) peptide is the major constituent of the extracellular amyloid plaques deposited in the brains of Alzheimer's disease patients and is central to the pathogenic pathway causing this disease. The identity of the neurotoxic Aβ species remains elusive. We previously reported that Aβ toxicity correlates strongly with its neuronal cell binding leading us to hypothesize that neuronal cell death is caused by the binding of a specific oligomeric Aβ species. To identify the specific oligomeric Aβ species that is associated with cell death, we treated mouse cortical neuronal cultures with synthetic Aβ40 and Aβ42 peptides and identified that the cellular Aβ binding and neurotoxicity were time and concentration dependent...
February 2016: Journal of Neurochemistry
Chia-Hsiang Chen, Amineh Aghabali, Alejandro J Metta-Magana, Marilyn M Olmstead, Alan L Balch, Luis Echegoyen
A new flexible hexakis-fullerene adduct with two bis(pyridin-4-ylmethyl)malonate groups located at trans-1 positions was synthesized. Via reaction with Ag(PF6) under two different conditions, two new 1D coordination polymers were obtained; under a nitrogen atmosphere, the silver ions are connected by argentophilic interactions but under an ambient atmosphere, the silver ions exhibit no interaction between them but coordination to the (H2PO4)(-) ions.
November 14, 2015: Dalton Transactions: An International Journal of Inorganic Chemistry
Sandhya Metta, Doddamani R Basalingappa, Satyanarayana Uppala, Geeta Mitta
BACKGROUND: Cigarette smoke promotes atherogenesis by producing oxygen-derived free radicals. AIM: The present study was conducted to determine the effect of cigarette smoking on lipid peroxidation and erythrocyte antioxidant status in ischemic heart disease (IHD). MATERIALS AND METHODS: A total of 327 male subjects were enrolled for this study, divided into two groups consisting of 200 patients, who were consecutively admitted for IHD in the intensive cardiac care unit (ICCU) of a Government Hospital and 127 age matched male healthy subjects...
June 2015: Journal of Clinical and Diagnostic Research: JCDR
Melanie G Mayer, Christian Rödelsperger, Hanh Witte, Metta Riebesell, Ralf J Sommer
Many nematodes form dauer larvae when exposed to unfavorable conditions, representing an example of phenotypic plasticity and a major survival and dispersal strategy. In Caenorhabditis elegans, the regulation of dauer induction is a model for pheromone, insulin, and steroid-hormone signaling. Recent studies in Pristionchus pacificus revealed substantial natural variation in various aspects of dauer development, i.e. pheromone production and sensing and dauer longevity and fitness. One intriguing example is a strain from Ohio, having extremely long-lived dauers associated with very high fitness and often forming the most dauers in response to other strains' pheromones, including the reference strain from California...
June 2015: PLoS Genetics
M K Metta, S Tantravahi, R Kunaparaju
The PCR—based replication assay is one of the most simple, quick and economical methods for the analysis of episomal replication. However, in spite of its advantages the method has not been able to replace the southern—based replication assay, the latter of which is a tedious and time—consuming process. This is due to the generation of spurious amplification products in the PCR—based replication assay. The replication assay is based on the use of methylation—sensitive restriction endonucleases (eg...
2015: Cellular and Molecular Biology
Sandhya Metta, Satyanarayana Uppala, Doddamani R Basalingappa, Srinivasa R Badeti, Geeta Mitta, Shruti Mohanty, Poornima Subhadra, Qurratulain Hasan
BACKGROUND: Ischemic heart disease (IHD) remains a major public health problem nationally and internationally. Smoking is a major risk factor for IHD.The deletion (D) allele of the angiotensin converting enzyme (ACE) gene polymorphism has been associated with hypertension, ischemic stroke and myocardial infarction. The present study was carried out to determine the association of the ACE gene insertion/deletion (I/D) polymorphism in IHD patients with and without smoking. MATERIALS AND METHODS: One hundred seven male IHD patients admitted consecutively in the Cardiology unit of a Government Hospital and 100 age and sex matched healthy controls were enrolled in this study...
April 2015: Journal of Clinical and Diagnostic Research: JCDR
Valentina Sulpizio, Giorgia Committeri, Emilia Metta, Simon Lambrey, Alain Berthoz, Gaspare Galati
In the visuospatial domain, perspective taking is the ability to imagine how a visual scene appears from an external observer's viewpoint, and can be studied by asking subjects to encode object locations in a visual scene where another individual is present and then detecting their displacement when seeing the scene from the other's viewpoint. In the current study, we explored the relationship between visuospatial perspective taking and self-report measures of the cognitive and emotional components of empathy in young adults...
July 2015: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
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