keyword
https://read.qxmd.com/read/12285590/labor-migration-amongst-hierarchically-competing-and-intervening-origins-and-destinations
#21
JOURNAL ARTICLE
T J Fik, R G Amey, G F Mulligan
"A spatial interaction methodology is developed for modeling flows in a hierarchical system. A competing and intervening destinations framework is employed to model and predict U.S. state-to-state labor migration. This analysis is used to assess the importance of geographic variables in explaining variations in regional labor flows. Empirical findings suggest that U.S. labor migration is largely explained by...size, distance, locational accessibility, and intervening opportunities in a spatial hierarchy. It is also suggested that lagged migration or migrant stock is a product of the combined effect of these forces...
September 1992: Environment & Planning A
https://read.qxmd.com/read/12238858/regulation-of-chemokine-expression-by-cyclosporine-a-in-alveolar-macrophages-exposed-to-hypoxia-and-reoxygenation
#22
JOURNAL ARTICLE
Babu V Naidu, Baiya Krishnadasan, Karen Byrne, Angie L Farr, Matthew Rosengart, Edward D Verrier, Michael S Mulligan
BACKGROUND: We have recently demonstrated a role for selected chemokines in a rat model of lung ischemia reperfusion injury (LIRI). We have further shown that pretreatment with cyclosporine A (CSA) is protective. The precise cellular events regulating this model are unknown. The alveolar macrophage (AM) is a key effector cell in multiple models of acute lung injury, and it likely plays a central role in LIRI as well. The present studies were undertaken to determine whether CSA functions in part by modifying the chemokine response of AMs to hypoxia and reoxygenation in vitro...
September 2002: Annals of Thoracic Surgery
https://read.qxmd.com/read/12184632/normal-transcription-of-the-c1-inhibitor-gene-is-dependent-upon-a-polypurine-polypyrimidine-region-within-the-promoter
#23
JOURNAL ARTICLE
Kamyar Zahedi, Anne E Prada, Aideen Mulligan, Jorge A Prada, Alvin E Davis
Analysis of the transcriptional activity of C1 inhibitor (CIINH) promoter reporter constructs with mutations in the R-Y region indicate that triplex formation by this region is not a predictor of transcriptional activity and that normal promoter function depends on the interaction of trans acting factors with specific elements within this region. Electrophoretic mobility shift assay (EMSA) of Hep3B nuclear extracts using the wild type promoter probe (nucleotides -98 to -9) yielded four major bands. Incubation of the same extracts with probes lacking the HNF-1 site resulted in the disappearance of one band...
August 2002: Inflammation
https://read.qxmd.com/read/11986604/decreased-lung-ischemia-reperfusion-injury-in-rats-after-preoperative-administration-of-cyclosporine-and-tacrolimus
#24
COMPARATIVE STUDY
B Krishnadasan, B Naidu, M Rosengart, A L Farr, A Barnes, E D Verrier, M S Mulligan
OBJECTIVES: Calcineurin inhibitors reduce experimental reperfusion injury in the liver, brain, heart, kidney, and small bowel. These studies were undertaken to determine whether these agents are similarly protective against lung ischemia-reperfusion injury. METHODS: Left lungs of male rats were rendered ischemic for 90 minutes and reperfused for as long as 4 hours. Treated animals received cyclosporine A (INN: ciclosporin; 1 or 5 mg/kg) or tacrolimus (0.2 mg/kg) 6 hours before ischemia, at reperfusion, or 2 hours after reperfusion...
April 2002: Journal of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/11516133/compilation-and-evaluation-of-a-paso-del-norte-emission-inventory
#25
JOURNAL ARTICLE
T H Funk, L R Chinkin, P T Roberts, M Saeger, S Mulligan, V H Páramo Figueroa, J Yarbrough
Emission inventories of ozone precursors are routinely used as input to comprehensive photochemical air quality models. Photochemical model performance and the development of effective control strategies rely on the accuracy and representativeness of an underlying emission inventory. This paper describes the tasks undertaken to compile and evaluate an ozone precursor emission inventory for the El Paso/Ciudad Juárez/Southern Doña Ana region. Point, area and mobile source emission data were obtained from local government agencies and were spatially and temporally allocated to a gridded domain using region-specific demographic and land-cover information...
August 10, 2001: Science of the Total Environment
https://read.qxmd.com/read/11054558/sp1-and-sp3-transactivate-the-ret-proto-oncogene-promoter
#26
JOURNAL ARTICLE
S D Andrew, P J Delhanty, L M Mulligan, B G Robinson
The RET proto-oncogene plays an important role in the initiation and progression of tumors derived from the neural crest. The cis-regulatory elements responsible for RET basal promoter activity have not been identified. To characterize these elements, a RET promoter DNA fragment (-453 to +227bp) was fused to a luciferase reporter and introduced into TT, a neural crest-derived cell line. Sequential 5' deletions of the promoter revealed that optimal expression of the RET promoter in TT cells required only 70bp of sequence upstream of the transcription start site, and contains two Sp1 binding sites...
October 3, 2000: Gene
https://read.qxmd.com/read/8932316/glbn-cyanoglobin-is-a-peripheral-membrane-protein-that-is-restricted-to-certain-nostoc-spp
#27
COMPARATIVE STUDY
D R Hill, T J Belbin, M V Thorsteinsson, D Bassam, S Brass, A Ernst, P Böger, H Paerl, M E Mulligan, M Potts
The glbN gene of Nostoc commune UTEX 584 is juxtaposed to nifU and nifH, and it encodes a 12-kDa monomeric hemoglobin that binds oxygen with high affinity. In N. commune UTEX 584, maximum accumulation of GlbN occurred in both the heterocysts and vegetative cells of nitrogen-fixing cultures when the rate of oxygen evolution was repressed to less than 25 micromol of O2 mg of chlorophyll a(-1) h(-1). Accumulation of GlbN coincided with maximum synthesis of NifH and ferredoxin NADP+ oxidoreductase (PetH or FNR)...
November 1996: Journal of Bacteriology
https://read.qxmd.com/read/3288541/specific-binding-of-proteins-from-rhizobium-meliloti-cell-free-extracts-containing-nodd-to-dna-sequences-upstream-of-inducible-nodulation-genes
#28
JOURNAL ARTICLE
R F Fisher, T T Egelhoff, J T Mulligan, S R Long
Nodulation (nod) genes in Rhizobium meliloti are transcriptionally induced by flavonoid signal molecules, such as luteolin, produced by its symbiotic host plant, alfalfa. This induction depends on expression of nodD. Upstream of three inducible nod gene clusters, nodABC, nodFE, and nodH, is a highly conserved sequence referred to as a 'nod box.' The upstream sequences have no other obvious similarity. We have found that DNA fragments containing the regions upstream of all three inducible transcripts show altered electrophoretic mobility when treated with R...
March 1988: Genes & Development
https://read.qxmd.com/read/2454400/dual-pathways-of-calcium-entry-in-spike-and-plateau-phases-of-luteinizing-hormone-release-from-chicken-pituitary-cells-sequential-activation-of-receptor-operated-and-voltage-sensitive-calcium-channels-by-gonadotropin-releasing-hormone
#29
JOURNAL ARTICLE
J S Davidson, I K Wakefield, J A King, G P Mulligan, R P Millar
It has previously been shown that, in pituitary gonadotrope cells, the initial rise in cytosolic Ca2+ induced by GnRH is due to a Ca2+ mobilization from intracellular stores. This raises the possibility that the initial transient spike phase of LH release might be fully or partially independent of extracellular Ca2+. We have therefore characterized the extracellular Ca2+ requirements, and the sensitivity to Ca2+ channel blockers, of the spike and plateau phases of secretion separately. In the absence of extracellular Ca2+ the spike and plateau phases were inhibited by 65 +/- 4% and 106 +/- 3%, respectively...
April 1988: Molecular Endocrinology
https://read.qxmd.com/read/1460042/polypyrimidine-tract-binding-protein-interacts-with-sequences-involved-in-alternative-splicing-of-beta-tropomyosin-pre-mrna
#30
JOURNAL ARTICLE
G J Mulligan, W Guo, S Wormsley, D M Helfman
Previous studies of alternative splicing of the rat beta-tropomyosin gene have shown that nonmuscle cells contain factors that block the use of the skeletal muscle exon 7 (Guo, W., Mulligan, G. J., Wormsley, S., and Helfman, D. M. (1991) Genes & Dev. 5, 2095-2106). Using an RNA mobility-shift assay we have identified factors in HeLa cell nuclear extracts that specifically interact with sequences responsible for exon blockage. Here we present the purification to apparent homogeneity of a protein that exhibits these sequence specific RNA binding properties...
December 15, 1992: Journal of Biological Chemistry
https://read.qxmd.com/read/183208/direct-biochemical-mapping-of-eukaryotic-viral-dna-by-means-of-a-linked-transcription-translation-cell-free-system
#31
JOURNAL ARTICLE
S Rozenblatt, R C Mulligan, M Gorecki, B E Roberts, A Rich
A method is described for mapping regions of eukaryotic viral DNA coding for specific proteins, utilizing a linked transcription-translation cell-free system primed with DNA fragments generated by restriction endonucleases. Three simian virus 40 (SV40) DNA fragments derived from that region of the DNA expressed late in lytic infection were purified. They were: Hpa I-A (0.76-0.175 map units), Bgl I-EcoRI-B (0.672-0), and Hpa II-EcoRI-B (0.735-0). (Fragments are named from the cleaving restriction endonuclease and electrophoretic mobility...
August 1976: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/168582/simian-virus-40-dna-directs-synthesis-of-authentic-viral-polypeptides-in-a-linked-transcription-translation-cell-free-system
#32
JOURNAL ARTICLE
B E Roberts, M Gorecki, R C Mulligan, K J Danna, S Rozenblatt, A Rich
A linked cell-free system has been developed which is capable of transcribing and translating mamalian viral DNA, and its characteristics and requirements are outlined. In this system, simian virus 40 (SV40) DNA Form I (supercoiled) directed the synthesis of discrete polypeptides up to 85,000 daltons in size. One of these products was indistingusihable from authentic major virus capsid protein VPI, as judged by mobility on sodium dodecyl sulfate/polyacrylamide gels, antibody predipitation, and peptide analyses...
May 1975: Proceedings of the National Academy of Sciences of the United States of America
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