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Mulligan,s mobilization

Clare Lewis, Rafael Diaz, Geoff Lopez, Nicholas Marki, Ben Olivio
OBJECTIVE: The purpose of this preliminary study was to determine if the use of Active Therapeutic Movement Version 2 (ATM2) device and home exercises using the Mulligan's mobilization-with-movement concept by subjects with scoliosis would result in postural improvement and to document any changes in trunk range of motion and quality of life. METHODS: Forty-three subjects between the ages of 12 to 75 years were recruited for the study. Each subject underwent a low back evaluation along with specific measurements for their scoliosis...
September 2014: Journal of Manipulative and Physiological Therapeutics
D R Mulligan, J W Patrick
Gibberellic acid (GA3), applied as a dispersion in aqueous lanolin to the stumps of decapitated stems of P. vulgaris plants, was found to promote the transfer of (14)C-and (32)P-labelled assimilates to the site of hormone application. Measurements of the component transfer processes, operating between source and sink (site of hormone application), showed that GA3 was not acting to promote assimilate transfer by increasing the photosynthetic rate of, or the assimilate export rate from the source, nor by altering the mobilizing ability of the competing root sink...
January 1979: Planta
J Kutzner-Mulligan, J Eisemann, P Siciliano, J Smith, K Hewitt, J Sharlette, S Pratt-Phillips
Management techniques that reduce the insulin response to feeding in horses have application in preventing insulin resistance (IR) and potential associations (e.g., laminitis). Eight mature idle horses of BCS between 5 and 6.5 and with no previous indication of IR were fed a meal of concentrate under 4 feed delivery treatments in a repeated Latin Square design. Treatments were all based on a bucket of equal dimensions. The treatments included a control (CON) and 3 treatments hypothesized to increase time to consume feed (TCF): mobile obstacles above the feed (BALL), stationary obstacles below the feed (WAFF), and feed with water added (WTR)...
August 2013: Journal of Animal Science
Juliet D French, Maya Ghoussaini, Stacey L Edwards, Kerstin B Meyer, Kyriaki Michailidou, Shahana Ahmed, Sofia Khan, Mel J Maranian, Martin O'Reilly, Kristine M Hillman, Joshua A Betts, Thomas Carroll, Peter J Bailey, Ed Dicks, Jonathan Beesley, Jonathan Tyrer, Ana-Teresa Maia, Andrew Beck, Nicholas W Knoblauch, Constance Chen, Peter Kraft, Daniel Barnes, Anna González-Neira, M Rosario Alonso, Daniel Herrero, Daniel C Tessier, Daniel Vincent, Francois Bacot, Craig Luccarini, Caroline Baynes, Don Conroy, Joe Dennis, Manjeet K Bolla, Qin Wang, John L Hopper, Melissa C Southey, Marjanka K Schmidt, Annegien Broeks, Senno Verhoef, Sten Cornelissen, Kenneth Muir, Artitaya Lophatananon, Sarah Stewart-Brown, Pornthep Siriwanarangsan, Peter A Fasching, Christian R Loehberg, Arif B Ekici, Matthias W Beckmann, Julian Peto, Isabel dos Santos Silva, Nichola Johnson, Zoe Aitken, Elinor J Sawyer, Ian Tomlinson, Michael J Kerin, Nicola Miller, Frederik Marme, Andreas Schneeweiss, Christof Sohn, Barbara Burwinkel, Pascal Guénel, Thérèse Truong, Pierre Laurent-Puig, Florence Menegaux, Stig E Bojesen, Børge G Nordestgaard, Sune F Nielsen, Henrik Flyger, Roger L Milne, M Pilar Zamora, Jose Ignacio Arias Perez, Javier Benitez, Hoda Anton-Culver, Hermann Brenner, Heiko Müller, Volker Arndt, Christa Stegmaier, Alfons Meindl, Peter Lichtner, Rita K Schmutzler, Christoph Engel, Hiltrud Brauch, Ute Hamann, Christina Justenhoven, Kirsimari Aaltonen, Päivi Heikkilä, Kristiina Aittomäki, Carl Blomqvist, Keitaro Matsuo, Hidemi Ito, Hiroji Iwata, Aiko Sueta, Natalia V Bogdanova, Natalia N Antonenkova, Thilo Dörk, Annika Lindblom, Sara Margolin, Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M Hartikainen, Anna H Wu, Chiu-chen Tseng, David Van Den Berg, Daniel O Stram, Diether Lambrechts, Stephanie Peeters, Ann Smeets, Giuseppe Floris, Jenny Chang-Claude, Anja Rudolph, Stefan Nickels, Dieter Flesch-Janys, Paolo Radice, Paolo Peterlongo, Bernardo Bonanni, Domenico Sardella, Fergus J Couch, Xianshu Wang, Vernon S Pankratz, Adam Lee, Graham G Giles, Gianluca Severi, Laura Baglietto, Christopher A Haiman, Brian E Henderson, Fredrick Schumacher, Loic Le Marchand, Jacques Simard, Mark S Goldberg, France Labrèche, Martine Dumont, Soo Hwang Teo, Cheng Har Yip, Char-Hong Ng, Eranga Nishanthie Vithana, Vessela Kristensen, Wei Zheng, Sandra Deming-Halverson, Martha Shrubsole, Jirong Long, Robert Winqvist, Katri Pylkäs, Arja Jukkola-Vuorinen, Mervi Grip, Irene L Andrulis, Julia A Knight, Gord Glendon, Anna Marie Mulligan, Peter Devilee, Caroline Seynaeve, Montserrat García-Closas, Jonine Figueroa, Stephen J Chanock, Jolanta Lissowska, Kamila Czene, Daniel Klevebring, Nils Schoof, Maartje J Hooning, John W M Martens, J Margriet Collée, Madeleine Tilanus-Linthorst, Per Hall, Jingmei Li, Jianjun Liu, Keith Humphreys, Xiao-Ou Shu, Wei Lu, Yu-Tang Gao, Hui Cai, Angela Cox, Sabapathy P Balasubramanian, William Blot, Lisa B Signorello, Qiuyin Cai, Paul D P Pharoah, Catherine S Healey, Mitul Shah, Karen A Pooley, Daehee Kang, Keun-Young Yoo, Dong-Young Noh, Mikael Hartman, Hui Miao, Jen-Hwei Sng, Xueling Sim, Anna Jakubowska, Jan Lubinski, Katarzyna Jaworska-Bieniek, Katarzyna Durda, Suleeporn Sangrajrang, Valerie Gaborieau, James McKay, Amanda E Toland, Christine B Ambrosone, Drakoulis Yannoukakos, Andrew K Godwin, Chen-Yang Shen, Chia-Ni Hsiung, Pei-Ei Wu, Shou-Tung Chen, Anthony Swerdlow, Alan Ashworth, Nick Orr, Minouk J Schoemaker, Bruce A J Ponder, Heli Nevanlinna, Melissa A Brown, Georgia Chenevix-Trench, Douglas F Easton, Alison M Dunning
Analysis of 4,405 variants in 89,050 European subjects from 41 case-control studies identified three independent association signals for estrogen-receptor-positive tumors at 11q13. The strongest signal maps to a transcriptional enhancer element in which the G allele of the best candidate causative variant rs554219 increases risk of breast cancer, reduces both binding of ELK4 transcription factor and luciferase activity in reporter assays, and may be associated with low cyclin D1 protein levels in tumors. Another candidate variant, rs78540526, lies in the same enhancer element...
April 4, 2013: American Journal of Human Genetics
Elizabeth A Mulligan, Eli Hatchwell, Sean R McCorkle, John J Dunn
The Escherichia coli McrA protein, a putative C(5)-methylcytosine/C(5)-hydroxyl methylcytosine-specific nuclease, binds DNA with symmetrically methylated HpaII sequences (Cm5CGG), but its precise recognition sequence remains undefined. To determine McrA's binding specificity, we cloned and expressed recombinant McrA with a C-terminal StrepII tag (rMcrA-S) to facilitate protein purification and affinity capture of human DNA fragments with m5C residues. Sequence analysis of a subset of these fragments and electrophoretic mobility shift assays with model methylated and unmethylated oligonucleotides suggest that N(Y > R) m5CGR is the canonical binding site for rMcrA-S...
April 2010: Nucleic Acids Research
Bill Vicenzino, Aatit Paungmali, Pamela Teys
There are an increasing number of reports espousing the clinically beneficial effects of Mulligan's mobilization-with-movement (MWM) treatment techniques. The most frequent reported effect is that of an immediate and substantial pain reduction accompanied by improved function. Prompted by these dramatic effects are questions regarding the mechanism(s) of action that underpins MWM. It appears timely that a review of the current literature is performed to synthesize and evaluate claims of the effectiveness of MWM and speculation about the proposed mechanisms of action...
May 2007: Manual Therapy
Garry S A Myers, David A Rasko, Jackie K Cheung, Jacques Ravel, Rekha Seshadri, Robert T DeBoy, Qinghu Ren, John Varga, Milena M Awad, Lauren M Brinkac, Sean C Daugherty, Daniel H Haft, Robert J Dodson, Ramana Madupu, William C Nelson, M J Rosovitz, Steven A Sullivan, Hoda Khouri, George I Dimitrov, Kisha L Watkins, Stephanie Mulligan, Jonathan Benton, Diana Radune, Derek J Fisher, Helen S Atkins, Tom Hiscox, B Helen Jost, Stephen J Billington, J Glenn Songer, Bruce A McClane, Richard W Titball, Julian I Rood, Stephen B Melville, Ian T Paulsen
Clostridium perfringens is a Gram-positive, anaerobic spore-forming bacterium commonly found in soil, sediments, and the human gastrointestinal tract. C. perfringens is responsible for a wide spectrum of disease, including food poisoning, gas gangrene (clostridial myonecrosis), enteritis necroticans, and non-foodborne gastrointestinal infections. The complete genome sequences of Clostridium perfringens strain ATCC 13124, a gas gangrene isolate and the species type strain, and the enterotoxin-producing food poisoning strain SM101, were determined and compared with the published C...
August 2006: Genome Research
Alexander S Farivar, Brendan MacKinnon-Patterson, Andrew D Barnes, Michael S Mulligan
BACKGROUND: Lung ischemia-reperfusion injury (LIRI) is associated with an increased incidence of both primary graft failure and obliterative bronchiolitis. The immunosuppressant mycophenolate mofetil (MMF) has recently been shown to attenuate inflammatory injury in acute ischemia-reperfusion models via a mechanism that is presently unclear. These experiments studied the effects of MMF in a warm, in situ LIRI model, focusing on transcriptional regulation of pro-inflammatory mediators. METHODS: Left lungs of rats were rendered ischemic for 90 minutes and reperfused for up to 4 hours...
December 2005: Journal of Heart and Lung Transplantation
Alexander S Farivar, Brendan Mackinnon-Patterson, Anton S McCourtie, Jane Namkung, Peter A Ward, Michael S Mulligan
Obliterative bronchiolitis is the major complication affecting long-term lung transplant survivors. Tumor necrosis factor-alpha (TNF-alpha) promotes inflammation and fibrosis in chronic lung injury models. These experiments defined the role of TNF-alpha in an established model of obliterative airway disease (OAD). Rat tracheas were transplanted from Brown-Norway donors into Lewis recipients, and explanted on days 7 and 14. Treated groups received either anti-TNF-alpha antibodies or a novel TNF-alpha translational inhibitor, RDP-58, beginning either immediately or on post-transplant day 7...
June 2005: Experimental and Molecular Pathology
Alexander S Farivar, Steven M Woolley, Babu V Naidu, Charles H Fraga, Karen Byrne, Robert Thomas, Andrew L Salzman, Csaba S Szabo, Michael S Mulligan
BACKGROUND: Obliterative bronchiolitis (OB) is the major long-term complication affecting lung transplant recipients, and is characterized pathologically by chronic inflammatory and fibroproliferative airway disease. Based on studies revealing anti-inflammatory and anti-apoptotic properties of poly (ADP)-ribose synthetase (PARS) inhibitors, we hypothesized that their administration would be protective in a heterotopic model of experimental OB. METHODS: We transplanted rat tracheas from Brown-Norway donors into Lewis recipients, and treated 2 groups with a novel PARS inhibitor, INO-1001...
August 2004: Journal of Heart and Lung Transplantation
Alexander S Farivar, Brendan Mackinnon-Patterson, Steven Woolley, Jane Namkung, Akira Shimamoto, Edward D Verrier, Michael S Mulligan
BACKGROUND: Obliterative bronchiolitis (OB) is the main cause of late mortality among long-term survivors of lung transplantation. Although p38 kinase is functional in multiple acute inflammatory injury models, its role in chronic lung rejection is undefined. p38 regulates the expression of the cytokines tumor necrosis (TNF)-alpha and interleukin (IL)-1beta, 2 mediators involved in the development of OB in a tracheal transplant model. These studies assessed whether specific inhibition of p38 with FR167653 (FR) protects against the development of OB in rat tracheal allografts...
August 2004: Journal of Heart and Lung Transplantation
Alexander S Farivar, Steven M Woolley, Charles H Fraga, Robert Thomas, Andrew L Salzman, Csaba Szabo, Michael S Mulligan
BACKGROUND: We previously demonstrated that intravenous poly (ADP) ribose synthetase (PARS) inhibition protects against experimental lung ischemia reperfusion injury (LIRI) in an in situ, hilar occlusion model. This study determined its efficacy when administered intratracheally (IT). METHODS: Left lungs of rats were rendered ischemic for 90 minutes, and reperfused for up to 4 hours. Treated animals received INO-1001, a PARS inhibitor, intratracheally 30 minutes before ischemia, while controls were given IT vehicle at equivalent volumes...
June 2004: Annals of Thoracic Surgery
Steven M Woolley, Alexander S Farivar, Babu V Naidu, Matthew Rosengart, Robert Thomas, Charles Fraga, Michael S Mulligan
OBJECTIVES: We previously demonstrated that calcineurin inhibitors given intravenously ameliorate experimental lung ischemia-reperfusion injury. This study evaluates whether these effects can be achieved when these agents are delivered endotracheally. METHODS: Left lungs of Long Evans rats were rendered ischemic for 90 minutes and reperfused for up to 4 hours. Treated animals received tacrolimus endotracheally at doses of 0.2, 0.1, or 0.025 mg/kg 60 minutes before ischemia...
February 2004: Journal of Thoracic and Cardiovascular Surgery
T J Fik, R G Amey, G F Mulligan
"A spatial interaction methodology is developed for modeling flows in a hierarchical system. A competing and intervening destinations framework is employed to model and predict U.S. state-to-state labor migration. This analysis is used to assess the importance of geographic variables in explaining variations in regional labor flows. Empirical findings suggest that U.S. labor migration is largely explained by...size, distance, locational accessibility, and intervening opportunities in a spatial hierarchy. It is also suggested that lagged migration or migrant stock is a product of the combined effect of these forces...
September 1992: Environment & Planning A
Babu V Naidu, Baiya Krishnadasan, Karen Byrne, Angie L Farr, Matthew Rosengart, Edward D Verrier, Michael S Mulligan
BACKGROUND: We have recently demonstrated a role for selected chemokines in a rat model of lung ischemia reperfusion injury (LIRI). We have further shown that pretreatment with cyclosporine A (CSA) is protective. The precise cellular events regulating this model are unknown. The alveolar macrophage (AM) is a key effector cell in multiple models of acute lung injury, and it likely plays a central role in LIRI as well. The present studies were undertaken to determine whether CSA functions in part by modifying the chemokine response of AMs to hypoxia and reoxygenation in vitro...
September 2002: Annals of Thoracic Surgery
Kamyar Zahedi, Anne E Prada, Aideen Mulligan, Jorge A Prada, Alvin E Davis
Analysis of the transcriptional activity of C1 inhibitor (CIINH) promoter reporter constructs with mutations in the R-Y region indicate that triplex formation by this region is not a predictor of transcriptional activity and that normal promoter function depends on the interaction of trans acting factors with specific elements within this region. Electrophoretic mobility shift assay (EMSA) of Hep3B nuclear extracts using the wild type promoter probe (nucleotides -98 to -9) yielded four major bands. Incubation of the same extracts with probes lacking the HNF-1 site resulted in the disappearance of one band...
August 2002: Inflammation
B Krishnadasan, B Naidu, M Rosengart, A L Farr, A Barnes, E D Verrier, M S Mulligan
OBJECTIVES: Calcineurin inhibitors reduce experimental reperfusion injury in the liver, brain, heart, kidney, and small bowel. These studies were undertaken to determine whether these agents are similarly protective against lung ischemia-reperfusion injury. METHODS: Left lungs of male rats were rendered ischemic for 90 minutes and reperfused for as long as 4 hours. Treated animals received cyclosporine A (INN: ciclosporin; 1 or 5 mg/kg) or tacrolimus (0.2 mg/kg) 6 hours before ischemia, at reperfusion, or 2 hours after reperfusion...
April 2002: Journal of Thoracic and Cardiovascular Surgery
T H Funk, L R Chinkin, P T Roberts, M Saeger, S Mulligan, V H Páramo Figueroa, J Yarbrough
Emission inventories of ozone precursors are routinely used as input to comprehensive photochemical air quality models. Photochemical model performance and the development of effective control strategies rely on the accuracy and representativeness of an underlying emission inventory. This paper describes the tasks undertaken to compile and evaluate an ozone precursor emission inventory for the El Paso/Ciudad Juárez/Southern Doña Ana region. Point, area and mobile source emission data were obtained from local government agencies and were spatially and temporally allocated to a gridded domain using region-specific demographic and land-cover information...
August 10, 2001: Science of the Total Environment
S D Andrew, P J Delhanty, L M Mulligan, B G Robinson
The RET proto-oncogene plays an important role in the initiation and progression of tumors derived from the neural crest. The cis-regulatory elements responsible for RET basal promoter activity have not been identified. To characterize these elements, a RET promoter DNA fragment (-453 to +227bp) was fused to a luciferase reporter and introduced into TT, a neural crest-derived cell line. Sequential 5' deletions of the promoter revealed that optimal expression of the RET promoter in TT cells required only 70bp of sequence upstream of the transcription start site, and contains two Sp1 binding sites...
October 3, 2000: Gene
D R Hill, T J Belbin, M V Thorsteinsson, D Bassam, S Brass, A Ernst, P Böger, H Paerl, M E Mulligan, M Potts
The glbN gene of Nostoc commune UTEX 584 is juxtaposed to nifU and nifH, and it encodes a 12-kDa monomeric hemoglobin that binds oxygen with high affinity. In N. commune UTEX 584, maximum accumulation of GlbN occurred in both the heterocysts and vegetative cells of nitrogen-fixing cultures when the rate of oxygen evolution was repressed to less than 25 micromol of O2 mg of chlorophyll a(-1) h(-1). Accumulation of GlbN coincided with maximum synthesis of NifH and ferredoxin NADP+ oxidoreductase (PetH or FNR)...
November 1996: Journal of Bacteriology
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