keyword
https://read.qxmd.com/read/38547357/which-older-adults-are-at-highest-risk-of-prescribing-cascades-a-national-study-of-the-gabapentinoid-loop-diuretic-cascade
#21
JOURNAL ARTICLE
Matthew E Growdon, Bocheng Jing, Earl J Morris, W James Deardorff, W John Boscardin, Amy L Byers, Kenneth S Boockvar, Michael A Steinman
BACKGROUND: Prescribing cascades are important contributors to polypharmacy. Little is known about which older adults are at highest risk of experiencing prescribing cascades. We explored which older veterans are at highest risk of the gabapentinoid (including gabapentin and pregabalin)-loop diuretic (LD) cascade, given the dramatic increase in gabapentinoid prescribing in recent years. METHODS: Using Veterans Affairs and Medicare claims data (2010-2019), we performed a prescription sequence symmetry analysis (PSSA) to assess loop diuretic initiation before and after gabapentinoid initiation among older veterans (≥66 years)...
March 28, 2024: Journal of the American Geriatrics Society
https://read.qxmd.com/read/38547348/prevalence-assessment-and-correlates-of-mental-health-problems-in-neglected-tropical-diseases-a-systematic-review
#22
JOURNAL ARTICLE
Samuel Adjorlolo, Emma Efua Adimado, Mawuko Setordzi, Vincent Valentine Akorli
Neglected tropical diseases (NTDs) are a group of disease conditions that affect the world's poorest people in low- and middle-income countries. NTDs are associated with negative behavioural experiences, including discrimination, rejection and stigmatization, that predisposes those affected to mental health problems. Consequently, researchers have shown profound interest in elucidating the mental health burden associated with NTDs. To address pertinent issues in the burgeoning literature relating to the prevalence, assessment and correlates of mental health problems in NTDs, a systematic review methodology was used...
March 28, 2024: International Health
https://read.qxmd.com/read/38547318/enantioselective-%C3%AE-boryl-carbene-transformations
#23
JOURNAL ARTICLE
Ming-Yao Huang, Jia-Bao Zhao, Cheng-Da Zhang, Yuan-Jun Zhou, Zhan-Sheng Lu, Shou-Fei Zhu
Carbenes, recognized as potent intermediates, enable unique chemical transformations, and organoborons are pivotal in diverse chemical applications. As a hybrid of carbene and the boryl group, α-boryl carbenes are promising intermediates for the construction of organoborons; unfortunately, such carbenes are hard to access and have low structural diversity with their asymmetric transformations largely uncharted. In this research, we utilized boryl cyclopropenes as precursors for the swift synthesis of α-boryl metal carbenes, a powerful category of intermediates for chiral organoboron synthesis...
March 28, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38547236/volumetric-quantification-identifies-some-left-atrial-dilations-undetected-by-left-atrium-aorta-ratio-measurements-a-prospective-echocardiographic-study-in-155-cavalier-king-charles-spaniels-with-and-without-degenerative-mitral-valve-disease
#24
JOURNAL ARTICLE
Valérie Chetboul, Camille Poissonnier, Pierre Foulex, Maria Paz Alvarado, Émilie Trehiou-Sechi, Vittorio Saponaro, Peggy Passavin, Loïc Desquilbet
INTRODUCTION: Degenerative mitral valve disease (DMVD) is the most common canine heart disease with a high predisposition in Cavalier King Charles Spaniels (CKCSs). Mitral regurgitation related to DMVD can lead to left atrial (LA) dilation, which is associated with survival time. Left-atrial-to-aortic (LA:Ao) ratio assessed by two-dimensional echocardiography is commonly used to evaluate LA size. The objectives of this prospective observational study were therefore 1) to compare different echocardiographic methods (i...
2024: PloS One
https://read.qxmd.com/read/38547227/low-board-pass-rates-in-blood-banking-transfusion-medicine
#25
JOURNAL ARTICLE
Gary W Procop, Tyler Sandersfeld, Mark K Fung
No abstract text is available yet for this article.
March 28, 2024: American Journal of Clinical Pathology
https://read.qxmd.com/read/38547139/association-between-sociodemographic-factors-clinic-characteristics-and-mental-health-screening-rates-in-primary-care
#26
JOURNAL ARTICLE
Frank Müller, Alyssa M Abdelnour, Diana N Rutaremara, Judith E Arnetz, Eric D Achtyes, Omayma Alshaarawy, Harland T Holman
BACKGROUND: Screening for mental health problems has been shown to be effective to detect depression and initiate treatment in primary care. Current guidelines recommend periodic screening for depression and anxiety. This study examines the association of patient sociodemographic factors and clinic characteristics on mental health screening in primary care. DESIGN: In this retrospective cohort study, electronic medical record (EMR) data from a 14-month period from 10/15/2021 to 12/14/2022 were analyzed...
2024: PloS One
https://read.qxmd.com/read/38547088/a-scoping-review-reducing-musculoskeletal-injury-risk-factors-for-adaptive-sport-athletes-through-prevention-programs
#27
JOURNAL ARTICLE
Samantha Koerber, Susan G Wager, Aaron J Zynda, Matthew T Santa Barbara
The purpose of this scoping review was to identify existing strategies to reduce modifiable risk factors for musculoskeletal injury in adaptive athletes. Medline, Embase, Web of Science, and CINAHL were searched. Inclusion criteria required studies written in English, samples of adaptive athletes, and evaluation of any injury prevention programs that would reduce risk factors associated with MSK injury. The literature search resulted in 785 unique articles. 32 full text articles were screened for inclusion...
March 25, 2024: American Journal of Physical Medicine & Rehabilitation
https://read.qxmd.com/read/38547051/bilateral-flexion-type-supracondylar-humerus-fracture
#28
JOURNAL ARTICLE
Muhammed Uslu, Mahsum Solmaz, Mustafa Fatih Daşcı, Ozan Beytemür
Supracondylar humerus fractures are common in the pediatric population, but flexion fractures are very rare in this population. The need for open reduction in these fractures is high and can be challenging for orthopaedic surgeons. In this article, we report a 9-year-old patient with bilateral flexion-type humeral fracture treated with closed reduction, which, to our knowledge, is the first report in the literature. We concluded that the first step in the treatment of flexion-type supracondylar fractures should be closed reduction with the help of an experienced assistant surgeon and that successful results can be obtained even in bilateral flexion-type fractures with appropriate treatment and follow-up...
April 1, 2024: Journal of the American Academy of Orthopaedic Surgeons. Global Research & Reviews
https://read.qxmd.com/read/38547046/the-use-of-biomarkers-to-quantify-clinical-response-to-total-knee-arthroplasty-interventions-a-systematic-review
#29
JOURNAL ARTICLE
Mark Mackie, Kristen I Barton, Darek Sokol-Randell, Brent Lanting
The primary objective of this review was to determine whether the attenuation of the postoperative inflammatory response (PIR) after total knee arthroplasty (TKA) leads to a notable improvement in clinical outcome scores. The secondary objective of this review was to determine the optimal approach in using inflammatory biomarkers, clinical inflammatory assessments, and imaging to quantify the PIR. A systematic literature search of eight major databases was conducted using a predetermined search strategy. C-reactive protein (CRP), interleukin-6 (IL-6), erythrocyte sedimentation rate (ESR), knee surface temperature (KST), and clinical outcome data were collected and graphically displayed...
April 1, 2024: Journal of the American Academy of Orthopaedic Surgeons. Global Research & Reviews
https://read.qxmd.com/read/38547045/value-driven-pediatric-supracondylar-humerus-fracture-care-implementing-evidence-based-practices
#30
JOURNAL ARTICLE
Sonia Chaudhry
Supracondylar humerus fractures are high-volume injuries in children; therefore, value-driven treatment has far-reaching implications for patients and families as well as healthcare systems. Children younger than 5 years can remodel posterior angulation. Most Type IIa fractures will maintain alignment after closed reduction. Many patients with surgical fractures can safely wait for nonemergent fixation. Outpatient surgery is associated with shorter surgical time, lower costs, and fewer return visits to the emergency department with no increase in adverse events...
April 1, 2024: Journal of the American Academy of Orthopaedic Surgeons. Global Research & Reviews
https://read.qxmd.com/read/38547041/covalent-organic-frameworks-as-single-site-photocatalysts-for-solar-to-fuel-conversion
#31
REVIEW
Liang Yao, Alexander M Pütz, Hugo Vignolo-González, Bettina V Lotsch
Single-site photocatalysts (SSPCs) are well-established as potent platforms for designing innovative materials to accomplish direct solar-to-fuel conversion. Compared to classical inorganic porous materials, such as zeolites and silica, covalent organic frameworks (COFs)─an emerging class of porous polymers that combine high surface areas, structural diversity, and chemical stability─are attractive candidates for SSPCs due to their molecular-level precision and intrinsic light harvesting ability, both amenable to structural engineering...
March 28, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38547040/diagnostic-neuromuscular-ultrasound-to-confirm-clinical-significance-of-a-genetic-variant-for-charcot-marie-tooth-type-4c-a-case-report
#32
JOURNAL ARTICLE
James B Meiling, Vanessa Baute Penry
Neuromuscular ultrasound (NMUS) has emerged as a beneficial, complementary tool to EMG in the diagnosis of neuromuscular diseases as it provides high-resolution anatomic imaging of peripheral nerves and muscles. It has been used previously as an adjunct to EMG to diagnose Charcot-Marie-Tooth disease (CMT). Here, we present a case of a 64-year-old male with bilateral sensorineural hearing loss of 14 years who presented to an outpatient neuromuscular clinic at a tertiary medical center with very slow progressive paresthesias...
March 26, 2024: American Journal of Physical Medicine & Rehabilitation
https://read.qxmd.com/read/38547030/expert-consensus-on-classification-and-performance-in-paralympic-powerlifting-a-delphi-study
#33
JOURNAL ARTICLE
Lorenzo Rum, Ruggero Romagnoli, Aldo Lazich, Tommaso Sciarra, Nicoletta Balletti, Maria Francesca Piacentini, Alessandro Boraschi, Elena Bergamini
BACKGROUND: In Paralympic sports, classification ensures fair competition by grouping athletes based on their impairments. The International Paralympic Committee has provided scientific principles to guide evidence-based classification procedures. In Paralympic Powerlifting (PPO), athletes compete in one class, divided by sex and bodyweight categories, overlooking impairment impact on performance. OBJECTIVE: This study aimed to establish a consensus among international PPO experts regarding classification and performance issues to guide future research...
March 25, 2024: American Journal of Physical Medicine & Rehabilitation
https://read.qxmd.com/read/38547029/pain-neuroscience-education-following-arthroscopic-rotator-cuff-repair-for-patients-with-rotator-cuff-tears-a-double-blind-randomized-controlled-clinical-trial
#34
JOURNAL ARTICLE
Caner Kararti, Fatih Özyurt, Muhammed İhsan Kodak, Hakkı Çağdaş, Gülşah Özsoy, İsmail Özsoy, Abdulhamit Tayfur
OBJECTIVE: This trial examines the efficacy of the Pain Neuroscience Education (PNE) on clinical outcomes in patients with arthroscopic rotator cuff repair (ARCR). DESIGN: A total of 36 participants undergoing ARCR were assigned to either the experimental group (n = 18) or control group (n = 18) in this randomized study. A 6-week-long conventional physiotherapy program was administered for both groups. In addition, a PNE protocol was administered for the experimental group for a whole period of 6 weeks (one session/week, 15-60 min per session)...
March 25, 2024: American Journal of Physical Medicine & Rehabilitation
https://read.qxmd.com/read/38547026/association-between-leg-muscle-thickness-and-walking-test-with-the-haemophilia-specific-functional-parameters
#35
JOURNAL ARTICLE
Jia-Pei Hong, Jiunn-Horng Kang, Chian-Her Lee, Chih-Hong Lee, Shu-Huey Chen, Yen-Lin Liu, Jia-Ruey Tsai, Chen-Hua Tsai, Wan-Ling Ho, Mei-Mei Cheng, Prangthip Charoenpong, Chia-Yau Chang
OBJECTIVE: To evaluate the muscle thickness and walking test in people with haemophilia A (PWH) and their correlation to joint health and functional impairments. DESIGN: Cross-sectional study. RESULTS: 29 severe/moderate PWH were enrolled. Muscle thickness of quadriceps and medial gastrocnemius were measured using ultrasound. Joint health and functional capacity were assessed using Haemophilia Joint Health Score (HJHS), Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US), 6-Minute Walking test (6MWT), Haemophilia Quality of Life Questionnaire for Adults (Haem-A-QoL), and Haemophilia Activities List (HAL)...
March 26, 2024: American Journal of Physical Medicine & Rehabilitation
https://read.qxmd.com/read/38547023/implementation-of-group-based-exercise-programs-in-physiotherapy-a-rapid-scoping-review
#36
JOURNAL ARTICLE
Mélanie Le Berre, Lauriane Forest, Chantale Dumoulin
This review synthesized implementation literature on group-based exercise programs in physiotherapy. MEDLINE and EMBASE databases were searched for English and French articles published between 2000 and 2022. Through a two-step process (titles/abstracts and full text), two independent reviewers selected studies. The independent reviewers then extracted data and assessed study quality using the Mixed Methods Appraisal Tool (MMAT). A total of 31 studies involving 4,555 participants were included. Data on the group-based programs were extracted using the Consensus on Exercise Reporting Template (CERT) and reported narratively...
March 25, 2024: American Journal of Physical Medicine & Rehabilitation
https://read.qxmd.com/read/38547022/chemical-and-photochemical-driven-dissipative-fe-3-fe-2-ion-cross-linked-carboxymethyl-cellulose-gels-operating-under-aerobic-conditions-applications-for-transient-controlled-release-and-mechanical-actuation
#37
JOURNAL ARTICLE
Roberto Baretta, Gilad Davidson-Rozenfeld, Vitaly Gutkin, Marco Frasconi, Itamar Willner
A Fe3+ -ion cross-linked carboxymethyl cellulose, Fe3+ -CMC, redox-active gel exhibiting dissipative, transient stiffness properties is introduced. Chemical or photosensitized reduction of the higher-stiffness Fe3+ -CMC to the lower-stiffness Fe2+ -CMC gel, accompanied by the aerobic reoxidation of the Fe2+ -CMC matrix, leads to the dissipative, transient stiffness, functional matrix. The light-induced, temporal, transient release of a load (Texas red dextran) and the light-triggered, transient mechanical bending of a poly- N -isopropylacrylamide (p-NIPAM)/Fe3+ -CMC bilayer construct are introduced, thus demonstrating the potential use of the dissipative Fe3+ -CMC gel for controlled drug release or soft robotic applications...
March 28, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38547006/aryl-azocyclopropeniums-minimalist-visible-light-photoswitches
#38
JOURNAL ARTICLE
Moritz Fink, Jannik Stäuble, Maïté Weisgerber, Erick M Carreira
We report convenient syntheses of aryl azocyclopropeniums and a study of their photochemical properties. Incorporation of the smallest arene leads to pronounced redshift of the π-π* absorbance band, compared to azobenzenes. Photoisomerization under purple or green light irradiation affords Z - or E -isomers in ratios up to 94% Z or 90% E , and the switches proved stable over multiple irradiation cycles. Thermal half-lives of metastable Z -isomers range from minutes to hours in acetonitrile and water...
March 28, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38546978/role-of-kcnk3-dysfunction-in-dasatinib-associated-pah-and-endothelial-cell-dysfunction
#39
JOURNAL ARTICLE
Hélène Le Ribeuz, Anaïs Saint-Martin Willer, Benoit Chevalier, Maria Sancho, Bastien Masson, Mélanie Eyries, Vincent Jung, Ida Chiara Guerrera, Mary Dutheil, Kristelle El Jekmek, Loann Laubry, Gilles Carpentier, Francisco Perez-Vizcaino, Ly Tu, Christophe Guignabert, Marie-Camille Chaumais, Christine Péchoux, Marc Humbert, Alexandre Hinzpeter, Olaf Mercier, Véronique Capuano, David Montani, Fabrice Antigny
Pulmonary arterial hypertension (PAH) is severe cardiopulmonary disease that may be triggered by exposure to drugs such as dasatinib or facilitated by genetic predispositions. The incidence of dasatinib-associated PAH is estimated at 0.45%, suggesting individual predispositions. The mechanisms of dasatinib-associated PAH are still incomplete. We discovered a KCNK3 gene (coding for outward K+ channel) variant in a patient with dasatinib-associated PAH, and we investigated the impact of this variant on KCNK3 function...
March 28, 2024: American Journal of Respiratory Cell and Molecular Biology
https://read.qxmd.com/read/38546971/risk-factors-for-thyroid-dysfunction-in-pregnancy-an-individual-participant-data-meta-analysis
#40
JOURNAL ARTICLE
Joris A J Osinga, Yindi Liu, Tuija Männistö, Marina Vafeiadi, Fang-Biao Tao, Bijay Vaidya, Tanja G M Vrijkotte, Lorena Mosso, Judit Bassols, Abel López-Bermejo, Laura Boucai, Ashraf Aminorroaya, Ulla Feldt-Rasmussen, Aya Hisada, Jun Yoshinaga, Maarten A C Broeren, Sachiko Itoh, Reiko Kishi, Ghalia Ashoor, Liangmiao Chen, Flora Veltri, Xuemian Lu, Peter N Taylor, Suzanne J Brown, Leda Chatzi, Polina V Popova, Elena N Grineva, Farkhanda Ghafoor, Amna Pirzada, Maryam Kianpour, Emily Oken, Eila Suvanto, Andrew Hattersley, Marisa Rebagliato, Isolina Riaño-Galán, Amaia Irizar, Martine Vrijheid, Juana Maria Delgado-Saborit, Ana Fernández-Somoano, Loreto Santa-Marina, Kristien Boelaert, Gabriela Brenta, Rima Dhillon-Smith, Chrysoula Dosiou, Jennifer L Eaton, Haixia Guan, Sun Y Lee, Spyridoula Maraka, Lilah F Morris-Wiseman, Caroline T Nguyen, Zhongyan Shan, Mònica Guxens, Victor J M Pop, John P Walsh, Kypros H Nicolaides, Mary E D'Alton, W Edward Visser, David M Carty, Christian Delles, Scott M Nelson, Erik K Alexander, Layal Chaker, Glenn E Palomaki, Robin P Peeters, Sofie Bliddal, Kun Huang, Kris G Poppe, Elizabeth N Pearce, Arash Derakhshan, Tim I M Korevaar
Background: International guidelines recommend targeted screening to identify gestational thyroid dysfunction. However, currently used risk factors have questionable discriminative ability. We quantified the risk for thyroid function test abnormalities for a subset of risk factors currently used in international guidelines. Methods: We included prospective cohort studies with data on gestational maternal thyroid function and potential risk factors (maternal age, body mass index [BMI], parity, smoking status, pregnancy through in vitro fertilization, twin pregnancy, gestational age, maternal education, and thyroid peroxidase antibody [TPOAb] or thyroglobulin antibody [TgAb] positivity)...
March 28, 2024: Thyroid: Official Journal of the American Thyroid Association
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