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https://www.readbyqxmd.com/read/28926390/misconceptions-misuses-and-misinterpretations-of-p-values-and-significance-testing
#1
Joel J Gagnier, Hal Morgenstern
The interpretation and reporting of p values and significance testing in biomedical research are fraught with misconceptions and inaccuracies. Publications of peer-reviewed research in orthopaedics are not immune to such problems. The American Statistical Association (ASA) recently published an official statement on the use, misuse, and misinterpretation of statistical testing and p values in applied research. The ASA statement discussed 6 principles: (1) "P-values can indicate how incompatible the data are with a specified statistical model...
September 20, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28922427/knowledge-evolution-in-physics-research-an-analysis-of-bibliographic-coupling-networks
#2
Wenyuan Liu, Andrea Nanetti, Siew Ann Cheong
Even as we advance the frontiers of physics knowledge, our understanding of how this knowledge evolves remains at the descriptive levels of Popper and Kuhn. Using the American Physical Society (APS) publications data sets, we ask in this paper how new knowledge is built upon old knowledge. We do so by constructing year-to-year bibliographic coupling networks, and identify in them validated communities that represent different research fields. We then visualize their evolutionary relationships in the form of alluvial diagrams, and show how they remain intact through APS journal splits...
2017: PloS One
https://www.readbyqxmd.com/read/28921584/we-didn-t-say-that-challenges-in-the-public-dissemination-of-a-research-finding-with-controversial-implications
#3
Zachary P Neal, Jennifer Watling Neal
In the March 2014 issue of American Journal of Community Psychology, we published an article that examined the tension between two core values in the field of community psychology: promoting contextual conditions that foster respect for diversity and promoting contextual conditions that foster sense of community. We concluded that processes of social network formation could help explain why diversity and sense of community are seemingly incompatible goals. The study's findings initially disseminated through the usual academic channels, and later through mainstream media outlets...
September 18, 2017: American Journal of Community Psychology
https://www.readbyqxmd.com/read/28902122/on-p-values-and-effect-modification
#4
Martin Mayer
AIM: A crucial element of evidence-based healthcare is the sound understanding and use of statistics. As part of instilling sound statistical knowledge and practice, it seems useful to highlight instances of unsound statistical reasoning or practice, not merely in captious or vitriolic spirit, but rather, to use such error as a springboard for edification by giving tangibility to the concepts at hand and highlighting the importance of avoiding such error. This article aims to provide an instructive overview of two key statistical concepts: effect modification and P values...
September 8, 2017: International Journal of Evidence-based Healthcare
https://www.readbyqxmd.com/read/28901325/associations-between-socio-demographic-characteristics-and-chemical-concentrations-contributing-to-cumulative-exposures-in-the-united-states
#5
Hongtai Huang, Rogelio Tornero-Velez, Timothy M Barzyk
Association rule mining (ARM) has been widely used to identify associations between various entities in many fields. Although some studies have utilized it to analyze the relationship between chemicals and human health effects, fewer have used this technique to identify and quantify associations between environmental and social stressors. Socio-demographic variables were generated based on U.S. Census tract-level income, race/ethnicity population percentage, education level, and age information from the 2010-2014, 5-Year Summary files in the American Community Survey (ACS) database, and chemical variables were generated by utilizing the 2011 National-Scale Air Toxics Assessment (NATA) census tract-level air pollutant exposure concentration data...
September 13, 2017: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/28895700/conflict-of-interest-nuances-between-principles-and-the-aim
#6
María E Serra
A conflict of interest exists when a health care provider's primary interest is at risk of being biased by a secondary interest that would cause harm. This concerns the different fields of professional practice. Based on a supplement of the Journal of the American Medical Association (JAMA) about conflicts of interest inviting to analyze the situation under the "Do No Harm" ethical principle, diverse scenarios are described, showing the intricacy and controversy of this topic. Elimination of conflict is not always possible, and there is consensus that science-based interactions among private organizations, health care providers and health institutions can be beneficial to patients...
October 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28895585/habitual-sleep-duration-and-sleep-duration-variation-are-independently-associated-with-body-mass-index
#7
X Xu, M P Conomos, O Manor, J E Rohwer, A T Magis, J C Lovejoy
BACKGROUND: Sleep plays a vital role in maintaining homeostasis and promoting health. Previous studies show that shorter sleep duration is associated with elevated body mass index (BMI) and other cardiovascular risk factors. The goal of this study was to investigate the effects of habitual sleep duration and nightly sleep duration variation based on daily device-recorded data on BMI and obesity-related biomarkers. METHOD: 748 individuals (50.6% females, 85.4% European-Americans, average age: 49...
September 12, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28886848/preparing-a-systematic-review-for-the-american-journal-of-ophthalmology-updated-guidance
#8
EDITORIAL
Gianni Virgili, Richard K Parrish
No abstract text is available yet for this article.
September 6, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28885999/weight-change-in-older-adults-and-mortality-the-multiethnic-cohort-study
#9
S-Y Park, L R Wilkens, G Maskarinec, C A Haiman, L N Kolonel, L L Marchand
OBJECTIVE: To investigate the association between weight change in older adults and mortality in a multiethnic population. METHODS: We performed a prospective analysis using data on weight change between the baseline (1993-1996) and the 10-year follow-up (2003-2007) surveys in relation to subsequent mortality among 63 040 participants in the Multiethnic Cohort Study in Hawaii and California. The participants were African American, Native Hawaiian, Japanese American, Latino and white, aged 45-75 years at baseline, and did not report heart disease or cancer at either survey...
August 14, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28871971/financial-relationships-with-industry-of-editorial-board-members-of-the-three-journals-of%C3%A2-the-american-society-for-radiation-oncology
#10
Vivek Verma
PURPOSE: To quantitate financial conflicts of interest (FCOIs) among radiation oncology peer-reviewers, specifically editorial board members of the 3 American Society for Radiation Oncology journals. METHODS AND MATERIALS: The public Centers for Medicare and Medicaid Services Open Payments database delineates payments in 3 categories (general payments, research funding, and company ownership). After excluding non-US and non-MDs, names of board members were searched...
October 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28866067/fostering-student-interest-in-neurological-surgery-the-university-of-pittsburgh-experience
#11
Ahmed Kashkoush, Rafey Feroze, Stephanie Myal, Arpan V Prabhu, Alexandra Sansosti, Daniel Tonetti, Nitin Agarwal
INTRODUCTION: Early involvement and research in neurosurgery can increase chances for medical students to successfully matriculate into residency. This study reports the creation of a Neurological Surgery Interest Group (NSIG) at the University of Pittsburgh School of Medicine and shares its activities over two academic years. METHODS: In October 2014, the University of Pittsburgh School of Medicine's NSIG was created to augment medical student interest in neurosurgery...
August 30, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28863043/pediatric-tandem-therapeutic-apheresis-a-multidisciplinary-approach
#12
Rachel M Sirignano, Erin K Meyer, Ross Fasano, Matthew L Paden
The epidemiology, safety, and efficacy of pediatric multiple tandem extracorporeal therapies are not well understood. We conducted a retrospective chart review of therapeutic apheresis (TA) from January 1, 2012 to October 31, 2015. We collected procedural/clinical demographics, American Society for Apheresis (ASFA) indication, complications, and mortality. One hundred eighty tandem TA procedures were performed in 53 patients. Median age was 9 years (range: 2 months to 21 years) with a median weight of 28 kg (range: 6-170...
August 31, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28856383/side-effects-of-radiotherapy-in-breast-cancer-patients-the-internet-as-an-information-source
#13
S Janssen, L Käsmann, F B Fahlbusch, D Rades, D Vordermark
AIM: Breast cancer is the most common cancer type among women necessitating adjuvant radiotherapy. As the Internet has become a major source of information for cancer patients, this study aimed to evaluate the quality of websites giving information on side effects of radiotherapy for breast cancer patients. METHODS: A patients' search for the English terms "breast cancer - radiotherapy - side effects" and the corresponding German terms "Brustkrebs - Strahlentherapie - Nebenwirkungen" was carried out twice (5 months apart) using the search engine Google...
August 30, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28852359/have-residents-produced-more-research-since-the-inception-of-the-80-hour-workweek
#14
David M Levy, Timothy J Luchetti, Brett R Levine
BACKGROUND: This study hypothesizes that resident involvement in research has increased since institution of the maximum 80-hour workweek in 2002. METHODS: All 571 papers published in the Journal of Bone and Joint Surgery (JBJS) in 1997 and 2007 (five years before and after the start of the 80-hour workweek) were reviewed. To identify resident authors, a search was performed in the American Board of Orthopaedic Surgery (ABOS) database for any U.S. author with a medical doctorate (MD)...
2017: Iowa Orthopaedic Journal
https://www.readbyqxmd.com/read/28841625/american-society-of-maxillofacial-surgeons-2006-to-2016-another-decade-of-excellence-in-education-and-research
#15
Gaby Doumit, Ali Totonchi, Andy Wexler, Arun K Gosain
Over the past 10 years, the American Society of Maxillofacial Surgeons (ASMS) has continued to advance to meet its mission of being the premier organization to represent maxillofacial and pediatric plastic surgery in the United States. These advances are focused on education of its members, to include the American Society of Maxillofacial Surgeons basic course, the preconference symposium, the annual meeting, two basic maxillofacial courses per year, advanced maxillofacial courses, a boot camp for craniofacial fellows, a cleft course, quarterly webinars, sponsored fellowships, a visiting professorship, and the ASMS journal...
September 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28841383/refinement-of-the-affordable-care-act
#16
Vivian Ho
Regardless of what legislation the federal government adopts to address health insurance coverage for nonelderly Americans, private insurance will likely play a major role. This article begins by listing some of the major reasons critics dislike the Affordable Care Act, then discusses the validity of these concerns from an economics perspective. Criticisms of the ACA include the increased role of government in healthcare, the ACA's implicit income redistribution, and concern about high and rising insurance premiums...
August 25, 2017: Annual Review of Medicine
https://www.readbyqxmd.com/read/28840931/parent-child-relationships-implementation-of-a-screening-and-referral-program-for-adolescents-with-mood-disorders
#17
Bryson C Okeoma
Parent-child relational problems (PCRP) have been increasingly recognized as a risk factor in the development and/or progression of childhood mental illnesses. Despite many young individuals being at risk, health care providers do not specifically screen for PCRP in children diagnosed with mental illnesses. The objective of the current project was to implement a PCRP screening program in a metropolitan children's hospital and refer those with PCRP for treatment. Adolescents ages 10 to 17 presenting for admission in an inpatient pediatric psychiatric unit were screened with the PCRP semi-structured questionnaire and diagnostic criteria developed by the American Psychiatric Association's Relational Processes Workgroup...
August 24, 2017: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/28826376/nutrition-from-the-inside-out
#18
Dennis M Bier
Nearly 50 years ago, I set out to investigate the clinical problem of hypoglycemia in children with illnesses that limited their food intake. My goal was to gather accurate and precise measurable data. At the time, I wasn't interested in nutrition as a discipline defined in its more general or popular sense. To address the specific problem that interested me required development of entirely new methods based on stable, nonradioactive tracers that satisfied the conditions of accuracy and precision. At the time, I had no inclination of the various theoretical and practical problems that would have to be solved to achieve this goal...
August 21, 2017: Annual Review of Nutrition
https://www.readbyqxmd.com/read/28822232/this-month-in-ajp
#19
(no author information available yet)
The following highlights summarize research articles that are published in the current issue of The American Journal of Pathology.
August 16, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28818559/-to-boldly-go-where-no-one-has-gone-before
#20
Keith W Kelley
Americans are suffering from a culture of taking pills. Six out of ten Americans utilize at least one prescription drug, and more than one in ten use five or more prescription medicines. Although this torrent of taking pills is already high, drug use in the USA has not yet crested. Prescription drugs have specific targets, but often they adversely affect other tissues and organs. In keeping with the mission of the recently named National Center for Complementary and Integrative Health (NCCIH), Brain, Behavior, and Immunity searches for the underlying cause and potential efficacy of both drug and non-drug interventions...
August 14, 2017: Brain, Behavior, and Immunity
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