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https://www.readbyqxmd.com/read/28634008/aging-associated-modifications-of-collagen-affect-its-degradation-by-matrix-metalloproteinases
#1
Preety Panwar, Georgina S Butler, Andrew Jamroz, Pouya Azizi, Christopher M Overall, Dieter Brömme
The natural aging process and various pathologies correlate with alterations in the composition and the structural and mechanical integrity of the connective tissue. Collagens represent the most abundant matrix proteins and provide for the overall stiffness and resilience of tissues. The structural changes of collagens and their susceptibility to degradation are associated with skin wrinkling, bone and cartilage deterioration, as well as cardiovascular and respiratory malfunctions. Here, matrix metalloproteinases (MMPs) are major contributors to tissue remodeling and collagen degradation...
June 17, 2017: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/28629129/dietary-management-of-skin-health-the-role-of-genistein
#2
REVIEW
Natasha Irrera, Gabriele Pizzino, Rosario D'Anna, Mario Vaccaro, Vincenzo Arcoraci, Francesco Squadrito, Domenica Altavilla, Alessandra Bitto
In women, aging and declining estrogen levels are associated with several cutaneous changes, many of which can be reversed or improved by estrogen supplementation. Two estrogen receptors-α and β-have been cloned and found in various tissue types. Epidermal thinning, declining dermal collagen content, diminished skin moisture, decreased laxity, and impaired wound healing have been reported in postmenopausal women. Experimental and clinical studies in postmenopausal conditions indicate that estrogen deprivation is associated with dryness, atrophy, fine wrinkling, and poor wound healing...
June 17, 2017: Nutrients
https://www.readbyqxmd.com/read/28628686/off-face-usage-of-poly-l-lactic-acid-for-body-rejuvenation
#3
Ahmad Jabbar, Suleima Arruda, Neil Sadick
<p>Injectable soft-tissue augmentation agents have become popular alternatives to surgical procedures for the aging face and body. In contrast to temporary, space-occupying replacement fillers such as collagen-based and hyaluronic acid products, poly-l-lactic acid (PLLA) has been demonstrated to gradually promotes deposition of collagen via a biostimulatory response, with therapeutic effects lasting approximately two years. In 2004, the FDA approved its use for rejuvenation of facial contours secondary to lipoatrophy associated with antiretroviral therapy for HIV infection...
May 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28625328/platelet-rich-plasma-for-the-treatment-of-photodamage-of-the-skin-of-the-hands
#4
J O Cabrera-Ramírez, A G Puebla-Mora, A González-Ojeda, D García-Martínez, J A Cortés-Lares, A R Márquez-Valdés, G I Contreras-Hernández, J Bracamontes-Blanco, J A Saucedo Ortiz, C Fuentes-Orozco
BACKGROUND: Platelet-rich plasma (PRP) provides growth factors that stimulate fibroblast activation and induce the synthesis of collagen and other components of the extracellular matrix. The objective of this study was to evaluate the effect of PRP in the treatment of photodamage of the skin of the hands. MATERIAL AND METHODS: This was an experimental study. Eighteen patients with aging of the skin of the dorsum of the hands (type III of the Glogau photoaging scale or class II of the Fitzpatrick wrinkle and elastosis scale) were included...
June 15, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28617579/programming-feature-size-in-thermal-wrinkling-of-metal-polymer-bilayer-by-modulating-substrate-visco-elasticity
#5
Anuja Das, Aditya Banerji, Rabibrata Mukherjee
We report a novel strategy to create stress induced self-organized wrinkles in a metal polymer bilayer with programmable periodicity (λS) varying over a wide range, from ≈ 20 m down to ≈ 800 nm by modulating the viscoelasticity of the bottom polymer layer. Substrates with different visco-elasticity are prepared by pre-curing thin films of a thermo-curable poly-dimethylsiloxane (PDMS) elastomer (Sylgard 184) for different durations (tP) prior to deposition of the top aluminum layer by thermal evaporation...
June 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28612301/erratum-to-the-clinical-experience-and-efficacy-of-radiofrequency-device-for-wrinkle-treatment
#6
Yeon A No, Beom Joon Kim, Myeung Nam Kim, Chang Kwun Hong
No abstract text is available yet for this article.
June 14, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28609855/two-new-species-of-tardigrada-eutardigrada-ramazzottiidae-macrobiotidae-from-the-supralittoral-zone-of-the-atlantic-iberian-peninsula-rocky-shores
#7
Paulo Fontoura, Marcos Rubal, Puri Veiga
Two new species of Eutardigrada were found in supralittoral lichens, growing on rocky shores at two localities of the Western Atlantic coast of the Iberian Peninsula. Ramazzottius littoreus sp. nov., found in San Cibrao (North of Spain), has the dorsal cuticle sculptured with small tubercles and claws with accessory points similar to R. oberhaeuseri. It can be distinguished from all the other known Ramazzottius species with the same type of cuticular sculpture by the dotted egg shell and the peculiar reticulation visible at the bulbous base of egg processes...
May 10, 2017: Zootaxa
https://www.readbyqxmd.com/read/28609168/forever-young-visual-representations-of-gender-and-age-in-online-dating-sites-for-older-adults
#8
Ateret Gewirtz-Meydan, Liat Ayalon
Online dating has become increasingly popular among older adults following broader social media adoption patterns. The current study examined the visual representations of people on 39 dating sites intended for the older population, with a particular focus on the visualization of the intersection between age and gender. All 39 dating sites for older adults were located through the Google search engine. Visual thematic analysis was performed with reference to general, non-age-related signs (e.g., facial expression, skin color), signs of aging (e...
June 13, 2017: Journal of Women & Aging
https://www.readbyqxmd.com/read/28607855/seri-surgical-scaffold-in-2-stage-breast-reconstruction-2-year-data-from-a-prospective-multicenter-trial
#9
Nolan Karp, Mihye Choi, David A Kulber, Susan Downey, Gloria Duda, Gabriel M Kind, Mark L Jewell, Diane K Murphy, Max R Lehfeldt, Neil Fine
BACKGROUND: Soft-tissue support devices are used during breast reconstruction. This study investigated long-term clinical data following SERI Surgical Scaffold (SERI) implantation, a bioresorbable, silk-derived scaffold for soft-tissue support. METHODS: This was a prospective, multicenter study in 103 subjects who received SERI during stage 1 of 2-stage breast reconstruction with subpectoral tissue expander placement (Natrelle Style 133V; Allergan plc, Dublin, Ireland) followed by subpectoral breast implant placement...
May 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28606525/inhaled-hyaluronic-acid-microparticles-extended-pulmonary-retention-and-suppressed-systemic-exposure-of-a-short-acting-bronchodilator
#10
Ying Li, Meihua Han, Tingting Liu, Dongmei Cun, Liang Fang, Mingshi Yang
The aim of this study was to investigate the feasibility of using hyaluronic acid (HA), a biomucoadhesive carbohydrate polymer to prolong the pulmonary retention and reduce the systemic exposure of inhaled medicine. Salbutamol sulphate (SAS), a model bronchodilator, was co-spray dried with HA into inhalable microparticles, which were subsequently characterized as spherical shape with wrinkled surface. The fine particle fraction of the microparticles tested by using the Next Generation Impactor was over 30% without the aid of any carrier, and the in vitro release of SAS lasted for 20h...
September 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28605051/ultrastructural-aspects-of-primary-anetoderma
#11
Joice Brião Göebel Pinto, Hiram Larangeira de Almeida, Luis Antônio Suíta de Castro, Nara Moreira Rocha
Anetoderma (anetos, Greek for slack) [1], also known as macular atrophy, is a rare elastolytic disorder characterized by circumscribed areas of flaccid skin due to focal loss of dermal elastic tissue, resulting in normochromic or erythematous papules and plaques with a wrinkled and atrophic surface.
June 12, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28604878/assessment-and-control-of-the-impermeability-of-graphene-for-atomically-thin-membranes-and-barriers
#12
Piran R Kidambi, Rebekah A Terry, Luda Wang, Michael S H Boutilier, Doojoon Jang, Jing Kong, Rohit Karnik
Two-dimensional materials such as graphene offer fundamentally transformative opportunities in membrane separations and as impermeable barriers, but the lack of facile methods to assess and control its 'impermeability' critically limits progress. Here we show that a simple etch of the growth catalyst (Cu) through defects in monolayer graphene synthesized by chemical vapor deposition (CVD) can be used to effectively assess graphene quality for membrane/barrier applications. Using feedback from the method to tune synthesis, we realize graphene with nearly no nanometer-scale defects as assessed by diffusion measurements, in contrast to commercially available graphene that is largely optimized for electronic applications...
June 12, 2017: Nanoscale
https://www.readbyqxmd.com/read/28595250/prospective-split-face-randomized-long-term-blinded-objective-comparison-of-the-performance-and-tolerability-of-two-new-hyaluronic-acid-fillers
#13
Patrick Trevidic, Pierre Andre, Laurent Benadiba, Jean-Jacques Deutsch, Olivier Galatoire, Philippe Garcia, Anne Grand-Vincent, Sylvie Boisnic, Jean-Charles Kerihuel, Catherine Salomon
BACKGROUND: There are requirements for long-term, objective comparisons of hyaluronic acid (HA) dermal fillers. OBJECTIVE: To compare efficacy and tolerability of ART FILLER Universal (AFU) and ART FILLER Fine lines (AFFL) with the existing HA fillers for the treatment of nasolabial folds and crow's feet. MATERIALS AND METHODS: Prospective, randomized, rater- and patient-blind, split-face comparison of AFU with JUVEDERM Ultra 3 (JUV) and AFFL with FIRST LINES PureSense (FLPS)...
June 6, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28588254/magnetic-anisotropy-and-high-frequency-property-of-flexible-fecota-films-obliquely-deposited-on-a-wrinkled-topography
#14
Jincai Li, Qingfeng Zhan, Shuanglan Zhang, Jinwu Wei, Jianbo Wang, Minjie Pan, Yali Xie, Huali Yang, Zheng Zhou, Shuhong Xie, Baomin Wang, Run-Wei Li
We investigated the magnetic anisotropy and the high-frequency property of flexible Fe60Co26Ta14 (FeCoTa) thin films obtained by oblique sputtering onto a wrinkled surface. The sinuously wrinkled topography is produced by growing Ta layer on a pre-strained polydimethylsiloxane (PDMS) membrane. Due to the enhanced effect of shadowing, the oblique deposition of FeCoTa layer gives rise to a shift of wrinkle peak towards the incident atomic flux. With increasing the PDMS pre-strain or increasing the oblique sputtering angle, both the uniaxial magnetic anisotropy and the ferromagnetic resonance frequency of FeCoTa films are enhanced, but the initial permeability decreases...
June 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28587311/genetic-variation-controlling-wrinkled-seed-phenotypes-in-pisum-how-lucky-was-mendel
#15
Tracey Rayner, Carol Moreau, Mike Ambrose, Peter G Isaac, Noel Ellis, Claire Domoney
One of the traits studied by Mendel in pea (Pisum sativum L.) was the wrinkled-seeded phenotype, and the molecular basis for a mutation underlying this phenotype was discovered in the 1990s. Although the starch-branching enzyme gene mutation identified at the genetic locus r is most likely to be that in seeds available to Mendel in the mid-1800s, it has remained an open question as to whether or not additional natural mutations in this gene exist within Pisum germplasm collections. Here, we explore this question and show that all but two wrinkled-seeded variants in one such collection correspond to either the mutant allele described previously for the r locus or a mutation at a second genetic locus, rb, affecting the gene encoding the large subunit of Adenosine diphosphoglucose (ADP-glucose) pyrophosphorylase; the molecular basis for the rb mutation is described here...
June 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28587261/ulmus-macrocarpa-hance-extracts-attenuated-h%C3%A2-o%C3%A2-and-uvb-induced-skin-photo-aging-by-activating-antioxidant-enzymes-and-inhibiting-mapk-pathways
#16
Sun-Il Choi, Jin-Ha Lee, Jae-Min Kim, Tae-Dong Jung, Bong-Yeon Cho, Seung-Hyun Choi, Dae-Won Lee, Jinkyung Kim, Jong-Yea Kim, Ok-Hawn Lee
To protect from reactive oxygen species (ROS) damages, skin cells have evolved to have antioxidant enzymes, such as copper and zinc-dependent superoxide dismutase (SOD1), mitochondrial manganese-dependent superoxide dismutase (SOD2), catalase (CAT), glutathione peroxidase (GPX), and glutathione reductase (GR), and suppressed the expression of matrix metalloproteinases (MMPs) through the mitogen-activated protein kinase (MAPK) signaling pathways, such as c-Jun N-terminal kinase (JNK) and p38. Bioactive compounds analyses were performed using a high-performance liquid chromatography-photodiode array detector (HPLC-PDA) system...
June 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28585335/comparison-of-two-skin-imaging-analysis-instruments-the-visia-%C3%A2-from-canfield-vs-the-antera-3d-%C3%A2-cs-from-miravex
#17
F Linming, H Wei, L Anqi, C Yuanyu, X Heng, P Sushmita, L Yiming, L Li
BACKGROUND: The skin imaging analysis instruments are widely used to record and measure the surface and subsurface skin conditions. The main aim of this study is to reveal the differences and correlations in measuring wrinkle, skin texture, coloration/evenness, vascular features, and pore between two commercially available instruments. METHODS: Twenty-eight subjects were enrolled in the study. A 2*2 cm cardboard was used to make sure the two instruments analyze the same area...
June 5, 2017: Skin Research and Technology
https://www.readbyqxmd.com/read/28583948/lysinibacillus-fusiformis-m5-induces-increased-complexity-in-bacillus-subtilis-168-colony-biofilms-via-hypoxanthine
#18
Ramses Gallegos-Monterrosa, Stefanie Kankel, Sebastian Götze, Robert Barnett, Pierre Stallforth, Ákos T Kovács
In recent years, biofilms have become a central subject of research in the fields of microbiology, medicine, agriculture, or systems biology amongst others. The sociomicrobiology of multispecies biofilms, however, is still poorly understood. Here, we report a screening system that allowed us to identify soil bacteria, which induce architectural changes in biofilm colonies when cocultured with B. subtilis We identified the soil bacterium Lysinibacillus fusiformis M5 as inducer of wrinkle-formation in B. subtilis colonies mediated by a diffusible signaling molecule...
June 5, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28583333/dry-powder-formulation-of-kanamycin-with-enhanced-aerosolization-efficiency-for-drug-resistant-tuberculosis
#19
Mohammad A M Momin, Shubhra Sinha, Ian G Tucker, Colin Doyle, Shyamal C Das
BACKGROUND: Kanamycin, an injectable agent, is currently used to treat drug-resistant tuberculosis (TB). Parenteral kanamycin causes high systemic toxicity which could be avoided by direct delivery to the lungs. This study focused on producing a highly aerosolizable dry-powder of hygroscopic kanamycin by spray-drying with l-leucine. METHODS: Kanamycin powders were prepared with different concentrations (0, 5, 10, 15 and 20% w/w) of l-leucine using the Buchi B-290 Mini Spray-Dryer...
June 3, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28582809/dietary-galacto-oligosaccharides-improve-skin-health-a-randomized-double-blind-clinical-trial
#20
Yang Hee Hong, Un Jae Chang, Young Suk Kim, Eun Young Jung, Hyung Joo Suh
BACKGROUND AND OBJECTIVES: To study the effects of galacto-oligosaccharides (GOS) on the skin, we investigated skin-related parameters in healthy adults who received GOS for 12 weeks. METHODS AND STUDY DESIGN: This double-blind, randomized, placebo-controlled study included subjects divided into two groups (control and GOS) by stratified block randomization. The GOS group received 1.0 g of GOS twice a day, whereas the control group received only vehicle. RESULTS: The results showed that the increase in corneometer values from baseline to week 12 was significantly greater in the GOS group than in the control group (6...
2017: Asia Pacific Journal of Clinical Nutrition
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