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Haidy Abbas, Rabab Kamel, Nesrine El-Sayed
In this study, Compritol ATO-based Resveratrol colloidal carriers (CCCs) were prepared. In most formulae, the use of a binary-mixture of surfactants improved the physicochemical properties. CCC6 (containing P407/P188 as bi-surfactants) attained the highest drug loading, release efficiency during 24 hr and occlusive effect for 48 hr; in addition to, a uniform particle size distribution within the desired range. In-vivo studies were done based on the analysis of anti-oxidant markers [catalase (CAT), reduced glutathione (GSH) and superoxide dismutase (SOD)], anti-inflammatory markers [interleukin 6 (IL-6), interleukin 8 (IL-8) and rat Nuclear factor-kappa B (NF-κB)] and anti-wrinkling markers [matrix metalloproteinase (MMP-1) and Granulocyte-macrophage colony-stimulating factor (GM-CSF)], after UVB-irradiation...
February 16, 2018: International Journal of Pharmaceutics
Yan Shao, Zhong-Liu Liu, Cai Cheng, Xu Wu, Hang Liu, Chen Liu, Jiaou Wang, Shi-Yu Zhu, Yu-Qi Wang, Dong-Xia Shi, Kurash Ibrahim, Jiatao Sun, Yeliang Wang, Hong-Jun Gao
Group-V elemental monolayers were recently predicted to exhibit exotic physical properties like nontrivial topological properties, or quantum anomalous Hall effect, which would make them very suitable for applications in next-generation electronic devices. The free-standing group-V monolayer materials usually have a buckled honeycomb form, in contrast with the flat graphene monolayer. Here, we report epitaxial growth of atomically thin flat honeycomb monolayer of group-V element antimony on a Ag(111) substrate...
February 19, 2018: Nano Letters
Emanual Maverakis, Chelsea Ma, Kanade Shinkai, David Fiorentino, Jeffrey P Callen, Uwe Wollina, Angelo Valerio Marzano, Daniel Wallach, Kyoungmi Kim, Courtney Schadt, Anthony Ormerod, Maxwell A Fung, Andrea Steel, Forum Patel, Rosie Qin, Fiona Craig, Hywel C Williams, Frank Powell, Alexander Merleev, Michelle Y Cheng
Importance: Pyoderma gangrenosum is a rare inflammatory skin condition that is difficult to diagnose. Currently, it is a "diagnosis of exclusion," a definition not compatible with clinical decision making or inclusion for clinical trials. Objective: To propose and validate diagnostic criteria for ulcerative pyoderma gangrenosum. Evidence Review: Diagnostic criteria were created following a Delphi consensus exercise using the RAND/UCLA Appropriateness Method...
February 14, 2018: JAMA Dermatology
Sang Won Choi, Min-Ho Oak, Eunyoung Yi, Hyun Jung Kim, Jin Woo Park
Percutaneous delivery of growth factors is often used to treat wounds, and for cosmetic purposes, as a way of accelerating healing and skin regeneration, respectively. However, the therapeutic effects of growth factors are diminished by their poor absorption when delivered percutaneously, in addition to their rapid degradation by proteinases. To overcome these obstacles, we constructed two skin-permeable compounds. Basic fibroblast growth factor (bFGF) and vascular endothelial growth factor-A (VEGF-A) were both genetically paired with low-molecular-weight protamine (LMWP), to yield the compounds LMWP-bFGF and LMWP-VEGF-A, respectively...
February 1, 2018: Journal of Nanoscience and Nanotechnology
Hasintha Wijesekara, Nanthi S Bolan, Lauren Bradney, Nadeeka Obadamudalige, Balaji Seshadri, Anitha Kunhikrishnan, Rajarathnam Dharmarajan, Yong Sik Ok, Jörg Rinklebe, M B Kirkham, Meththika Vithanage
This study focused on quantifying and characterising microbeads in biosolids (i.e., treated sewage sludge), and in examining interactions of microbeads with trace elements when biosolids are added to soil. Under laboratory conditions, batch experiments were conducted to investigate the adsorption of Cu onto pure and surface modified microbeads suspended in soil. The ecotoxicity of microbead-metal complexes to soil microbial activities was also investigated by monitoring basal respiration and dehydrogenase activity...
February 1, 2018: Chemosphere
Seungdu Kim, Kook In Han, In Gyu Lee, Woo Seok Yang, Wan Sik Hwang
Wrinkled graphene oxide (WGO) is formed using the solution method. The sub-μm-sized wrinkles are generated on the GO surface, with more wrinkles forming as the GaCl3 in the solution increases. The wrinkles are observed using scanning electron microscopy (SEM) and atomic force microscopy (AFM) methods. The OH bonds connected to the GO surface are believed to cause the WGO, and these additional chemical bonds are detected via the Fourier transform infrared spectroscopy (FTIR) and Raman spectroscopy. As with the wrinkled graphene, the wrinkled GO provides a much larger surface area and can expedite the production of advanced sensor and energy charging devices...
June 1, 2018: Journal of Nanoscience and Nanotechnology
Reena A Majithia, Leni George, Meera Thomas, N A Fouzia
Acquired cutis laxa (ACL) is a rare connective tissue disorder characterized by pendulous and coarsely wrinkled skin. There have been few cases of its association to monoclonal immunoglobulin deposition disease (MIDD), which constitutes the light chain (LCDD), heavy chain (HCDD), and light and heavy chain (LHCDD) deposition disease. MIDD predominantly involves the kidney. Skin is the next common organ to be affected by HCDD, which presents as ACL. We report the case of a 40-year-old male who presented with ACL associated with LHCDD...
January 2018: Indian Dermatology Online Journal
Jungtae Na, Dong-Ho Bak, Song I Im, Hyangtae Choi, Jung Hyun Hwang, Su Yeon Kong, Yeon A No, Yonghee Lee, Beom Joon Kim
It has been established that glycosaminoglycans (GAGs) serve an important role in protecting the skin against the effects of aging. A previous clinical trial by our group identified that a cream containing GAGs reduced wrinkles and increased skin elasticity, dermal density and skin tightening. However, the exact molecular mechanism underlying the anti‑aging effect of GAGs has not yet been fully elucidated. The present study assessed the influence of GAGs on cell viability, collagen synthesis and collagen synthesis‑associated signaling pathways in tumor necrosis factor‑α (TNF‑α)‑stimulated human dermal fibroblasts (HDFs); an in vitro model of aging...
February 12, 2018: International Journal of Molecular Medicine
Wenjing Li, Wanyun Zhu, Chaoxiang Lv, Hao Qu, Kaixiang Xu, Honghui Li, Haifeng Li, Yiming Du, Guangming Liu, Yunyue Wang, Hong-Jiang Wei, Hong-Ye Zhao
Paclitaxel (PTX) has been commonly used to treat multiple types of tumor. Its anticancer mechanism differs based on different PTX concentrations and types of tumor cell. In the present study, MTT assays of HCT116 and LOVO cells treated with PTX revealed the chemosensitivity of the cell lines for different PTX concentrations. The half-maximal inhibitory concentration values of PTX for these cells were 2.46 and 2.24 nM, respectively. Cell morphology observation revealed that both cell lines exhibited rounded, wrinkled and damaged morphologies with increasing concentrations of PTX...
February 2018: Oncology Letters
Jing-Chun Zhao, Bo-Ru Zhang, Kai Shi, Jian Wang, Qing-Hua Yu, Jia-Ao Yu
The aim of the present study was to investigate the effects of radial extracorporeal shock wave therapy (rESWT) on scar characteristics and transforming growth factor (TGF)-β1/Smad signaling in order to explore a potential modality for the treatment of hypertrophic scars (HS). The HS model was generated in rabbit ears, then rabbits were randomly divided into 3 groups: Lower (L)-ESWT [treated with rESWT with lower energy flux density (EFD) of 0.1 mJ/mm2], higher (H)-ESWT (treated with a higher EFD of 0.18 mJ/mm2) and the sham ESWT group (S-ESWT; no ESWT treatment)...
January 2018: Experimental and Therapeutic Medicine
S P Pearce, J R King, T Steinbrecher, G Leubner-Metzger, N M Everitt, M J Holdsworth
Experimentally measuring the elastic properties of thin biological surfaces is non-trivial, particularly when they are curved. One technique that may be used is the indentation of a thin sheet of material by a rigid indenter, while measuring the applied force and displacement. This gives immediate information on the fracture strength of the material (from the force required to puncture), but it is also theoretically possible to determine the elastic properties by comparing the resulting force-displacement curves with a mathematical model...
January 2018: Proceedings. Mathematical, Physical, and Engineering Sciences
Eunson Hwang, Hien T T Ngo, Seul A Seo, Bom Park, Mengyang Zhang, Tae-Hoo Yi
BACKGROUND: Alchemilla mollis (lady's mantle) is a common ingredient in skin care products. However, the protective mechanism of A. mollis against skin problems has not been elucidated. PURPOSE: This study was to investigate the effects of A. mollis ethanolic extract (AM) on UVB-irradiated normal human dermal fibroblasts (NHDF) and hairless mice. METHODS: The in vitro anti-photoaging effect of AM was performed in NHDFs. The antioxidant activities were assessed through DPPH, ABTS, and reactive oxygen species (ROS) assays...
January 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Vanessa Webber, Daniel de Siqueira Ferreira, Pedro Luis Manique Barreto, Valeria Weiss-Angeli, Regina Vanderlinde
Reduced glutathione (GSH) is an efficient antioxidant on limitation of browning, of the loss of aromas and off-flavor formation in white wines. The encapsulation of GSH in a polymer system to be added in white wines may prolong its antioxidant action. The aim of this work was to prepare and characterize spray-dried microparticles using β-cyclodextrin (β-CD) or chitosan as polymers for encapsulation of GSH for its addition to wine to prevent oxidation. The microparticles obtained after the drying process were characterized regarding morphology, chemical interaction between GSH and polymers, thermal stability, microstructure, encapsulation efficiency and in vitro GSH release...
March 2018: Food Research International
Cheng Zhang, Yu-Kun Hao, Bo Li, Xi-Qiao Feng, Huajian Gao
Curvature plays an important role in the morphological evolution of soft shells under stretch. Here, through a combination of experiment, theory and simulation, we investigate the behavior of a hemispherical soft shell subject to an increasing outward point force at its pole. In contrast to an inward point force inducing a polygonal pattern of buckling in the shell, we observe a four-stage morphological transition and symmetry breaking under an increasing outward point force. The shell undergoes axisymmetric deformation around its pole and then buckles into a non-axisymmetric shape with a number of shallow wrinkles emanating from the pole, followed by the emergence of crater-like deep crumples and ultimately a transformation into a wrinkled pseudocone...
February 8, 2018: Soft Matter
Massimo Milani, Adele Sparavigna
Background: Skin is a complete and independent melatoninergic system. At the skin level, melatonin (Mel) acts as a relevant antioxidant and cytoprotective substance. Topical application of Mel is considered meaningful, since it can easily penetrate the stratum corneum. Exogenous Mel can be expected to represent a potent antioxidative defense system against skin aging mechanisms. Day and night creams containing Mel, carried in lipospheres (Melatosphere™), have been developed (Nutriage SPF 30 day cream and Nutriage night cream)...
2018: Clinical, Cosmetic and Investigational Dermatology
Melanie L Church, Daniel R Priehs, Heidi Denis, Lara Croft, Stacy DiRocco, Michelle Davis
OBJECTIVE: To describe surgical technique, postoperative complications, and visual outcome in penguins after phacoemulsification lens extraction surgery. ANIMALS STUDIED: Twenty-one penguins (27 eyes) that had phacoemulsification from 2011 to 2015 at Animal Eye Associates. Species included are as follows: 14 southern Rockhopper (18 eyes, 66.6%), 4 Gentoo (4 eyes, 19%), 2 King (3 eyes, 9.5%), and 1 Chinstrap penguin (2 eyes, 4.8%). Eleven of the penguins were females, and 10 were males with average age at the time of surgery being 27...
February 6, 2018: Veterinary Ophthalmology
Skylar A Souyoul, Katharine P Saussy, Mary P Lupo
Skin aging is continuously influenced by various internal and external factors such as the biologic progression of cells, ultraviolet (UV) radiation, tobacco, nutritional deficiencies, and hormonal imbalances that lead to the degradation of skin cells. Through the degradation of skin cells, free radicals and inflammation weaken repair mechanisms and result in collagen and elastic fiber breakdown. The appearance of aging skin is highlighted by skin roughness, wrinkling, pigmentation change, telangiectasias, loss of elasticity, and decreased firmness, all of which are accelerated by these internal and external factors...
February 6, 2018: Dermatology and Therapy
Yulong Ying, Wen Ying, Yi Guo, Xinsheng Peng
Graphene oxide (GO) membrane is promising for molecule separation. However, it is still a big challenge to achieve highly stable pristine GO membranes, especially in water. In this work, an ultrathin and robust GO membrane is assembled via cross-flow method. The resulted 12 nm thick GO membrane (GOCF membrane) presents high stability with best water permeance of 1505±65 litre per hour per square meters per bar (LHM bar-1) and Evans Blue rejection of 98.7±0.4 %, 21-fold enhancement in water permeance from that of pristine GO membrane (50-70 LHM bar-1) and 100 times higher than that of commercial ultrafiltration membranes (15 LHM...
February 6, 2018: Nanotechnology
P Ciarletta
A soft solid subjected to a large compression develops sharp self-contacting folds at its free surface, known as creases. Creasing is physically different from structural elastic instabilities, like buckling or wrinkling. Indeed, it is a fully nonlinear material instability, similar to a phase-transformation. This work provides theoretical insights of the physics behind crease nucleation. Creasing is proved to occur after a global bifurcation allowing the co-existence of an outer deformation and an inner solution with localised self-contact at the free surface...
February 5, 2018: Nature Communications
G Franchi, C Neiva-Vaz, A Picard, M-P Vazquez
BACKGROUND: Cross-linked hyaluronic acid-based fillers have gained rapid acceptance for treating facial wrinkles, deep tissue folds and sunken areas due to aging. This study evaluates, in addition to space-filling properties, their effects on softness and elasticity as a secondary effect, following injection of 3 commercially available cross-linked hyaluronic acid-based fillers (15mg/mL, 17,5mg/mL and 20mg/mL) in patients presenting with congenital or acquired facial malformations. PATIENTS ET METHODS: We started injecting gels of cross-linked hyaluronic acid-based fillers in those cases in 2013; we performed 46 sessions of injections in 32 patients, aged from 13-32...
February 2, 2018: Annales de Chirurgie Plastique et Esthétique
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