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https://www.readbyqxmd.com/read/29046820/bioimaging-of-botulinum-toxin-and-hyaluronate-hydrogels-using-zwitterionic-near-infrared-fluorophores
#1
Ki Su Kim, Yun Seop Kim, Kai Bao, Hideyuki Wada, Hak Soo Choi, Sei Kwang Hahn
BACKGROUND: The injection of botulinum toxin (BTX) to reduce facial wrinkles is one of the most frequently performed plastic surgery procedures. The biocompatible hydrogels are injected with BTX for effective tissue augmentation. However, it is difficult to determine the interval of injection for effective tissue augmentation. METHOD: BTX and hyaluronate (HA) hydrogels were labeled with zwitterionic (ZW) near-infrared (NIR) fluorophores and visualized for 3 weeks after injection to BALB/c nude mice...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/29045012/photodynamic-therapy-inhibits-melanogenesis-through-paracrine-effects-by-keratinocytes-and-fibroblasts
#2
Sue Kyung Kim, Seung-Jae Oh, Se-Yeon Park, Woo-Jung Kim, You-Sun Kim, You Chan Kim
Photodynamic therapy (PDT) is a treatment option for skin cancer and premalignant skin diseases and exhibits rejuvenation effects, including reducing fine wrinkles and whitening, on aged skin. In the present study, we investigated the mechanism underlying the whitening effects of PDT on melanocytes in vitro and in vivo. Exposure of melanocytes to PDT in vitro reduced their melanin content and tyrosinase activity without, however, affecting cell survival. Interestingly, melanogenesis was also inhibited by exposing melanocytes to conditioned media of PDT-treated keratinocytes or dermal fibroblasts...
October 17, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29044361/percutaneous-myotomy-with-a-small-needle-knife-and-lipoinjection-for-treatment-of-glabellar-frown-lines
#3
Xiaogen Hu, Zhiqiang Xue, Huijie Qi, Bo Chen
Background: Glabellar frown lines are a common aesthetic concern, and minimally invasive techniques to treat frown lines have become popular. Objectives: The authors developed a technique to minimize frown lines by means of percutaneous myotomy with a small needle-knife and lipoinjection. Methods: Sixty-nine patients underwent treatment of the glabellar frown lines in a prospective study. Percutaneous myotomy of the corrugator supercilii and procerus was conducted with a small needle-knife, and autologous fat was transferred to the glabellar region...
October 16, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29044284/buckling-patterns-in-biaxially-pre-stretched-bilayer-shells-wrinkles-creases-folds-and-fracture-like-ridges
#4
Rashed Al-Rashed, Francisco López Jiménez, Joel Marthelot, Pedro M Reis
We introduce a new experimental system to study the effects of pre-stretch on the buckling patterns that emerge from the biaxial compression of elastomeric bilayer shells. Upon fabrication of the samples, releasing the pre-stretch in the substrate through deflation places the outer film in a state of biaxial compression and yields a variety of buckling patterns. We systematically explore the parameter space by varying the pre-stretch of the substrate and the ratio between the stiffness of the substrate and film...
October 18, 2017: Soft Matter
https://www.readbyqxmd.com/read/29042545/gate-controlled-reversible-rectifying-behaviour-in-tunnel-contacted-atomically-thin-mos2-transistor
#5
Xiao-Xi Li, Zhi-Qiang Fan, Pei-Zhi Liu, Mao-Lin Chen, Xin Liu, Chuan-Kun Jia, Dong-Ming Sun, Xiang-Wei Jiang, Zheng Han, Vincent Bouchiat, Jun-Jie Guo, Jian-Hao Chen, Zhi-Dong Zhang
Atomically thin two-dimensional semiconducting materials integrated into van der Waals heterostructures have enabled architectures that hold great promise for next generation nanoelectronics. However, challenges still remain to enable their applications as compliant materials for integration in logic devices. Here, we devise a reverted stacking technique to intercalate a wrinkle-free boron nitride tunnel layer between MoS2 channel and source drain electrodes. Vertical tunnelling of electrons therefore makes it possible to suppress the Schottky barriers and Fermi level pinning, leading to homogeneous gate-control of the channel chemical potential across the bandgap edges...
October 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/29039482/protective-effects-of-compounds-from-garcinia-mangostana-l-mangosteen-against-uvb-damage-in-hacat-cells-and-hairless-mice
#6
A-Rang Im, Young-Mi Kim, Young-Won Chin, Sungwook Chae
Ultraviolet B (UVB) radiation causes alterations in the skin, such as epidermal thickening, wrinkle formation and inflammation. Therefore, preventing UVB-induced skin damage can promote general health among the human population. Garcinia mangostana L. (mangosteen) is a fruit that has become a popular botanical dietary supplement because of its perceived role in promoting overall health. The present study investigated the photoprotective effects of α-, β-, γ-mangostins and gartanin against UVB radiation using the HaCaT immortalized human keratinocyte cell line as an in vitro model and hairless mice as an in vivo model...
October 13, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29035324/a-mesoscopic-analytical-model-to-predict-the-onset-of-wrinkling-in-plain-woven-preforms-under-bias-extension-shear-deformation
#7
Abbas Hosseini, Masoud Haghi Kashani, Farrokh Sassani, Abbas S Milani, Frank Ko
A mesoscopic analytical model of wrinkling of Plain-Woven Composite Preforms (PWCPs) under the bias extension test is presented, based on a new instability analysis. The analysis is aimed to facilitate a better understanding of the nature of wrinkle formation in woven fabrics caused by large in-plane shear, while it accounts for the effect of fabric and process parameters on the onset of wrinkling. To this end, the mechanism of wrinkle formation in PWCPs in mesoscale is simplified and an equivalent structure composed of bars and different types of springs is proposed, mimicking the behavior of a representative PWCP element at the post-locking state...
October 16, 2017: Materials
https://www.readbyqxmd.com/read/29034929/wrinkling-to-delamination-transition-in-thin-polymer-films-on-compliant-substrates
#8
Adam J Nolte, Jun Young Chung, Chelsea S Davis, Christopher M Stafford
Compressing a thin, stiff film attached to a thick, compliant substrate can lead to a number of different modes of mechanical deformation depending upon the material properties of the system. In this article we explore direct transitions from surface wrinkling to buckle delamination, and provide a theoretical framework for understanding the conditions under which such transitions take place, as well as the resulting dimensions of the wrinkling-induced delamination. A key conclusion of this work is that the width of the delamination blister formed from a wrinkled film is relatively strain-independent, suggesting that delaminations can be used in such systems to measure the adhesion energy at the film-substrate interface...
October 16, 2017: Soft Matter
https://www.readbyqxmd.com/read/29025226/a-histopathologic-diagnosis-of-vascular-occlusion-after-injection-of-hyaluronic-acid-filler-findings-of-intravascular-foreign-body-and-skin-necrosis
#9
Seiichi Maruyama
Before injecting hyaluronic acid (HA) filler into high-risk zones of the face, considerable caution must be exercised, including careful selection of the most appropriate filler, volume, and injection technique. Rare but severe adverse events have occurred during and after injection of HA filler in or around the periorbital region, such as skin necrosis and blindness. In the present case, involving a 57-year-old woman, approximately 0.1 mL of HA was injected into each side of the glabella to minimize wrinkles...
October 1, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29024034/maternal-control-of-embryogenesis-by-mpk6-and-its-upstream-mkk4-and-mkk5-in-arabidopsis
#10
Mengmeng Zhang, Hongjiao Wu, Jianbin Su, Huachun Wang, Qiankun Zhu, Yidong Liu, Juan Xu, Wolfgang Lukowitz, Shuqun Zhang
In flowering plants, developing embryos reside in maternal sporophytes. It is known that maternal generation influences the development of next-generation embryos. However, little is known about the signaling components in the process. Previously, we demonstrated that Arabidopsis mitogen-activated protein kinase 6 (MPK6) and MPK3 play critical roles in plant reproduction. In addition, we noticed that a large fraction of seeds from mpk6 single mutant plants showed a wrinkled seed coat or a burst-out embryo phenotype...
October 10, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29021691/photoprotective-effects-of-topical-ginseng-leaf-extract-using-ultraflo-l-against-uvb-induced-skin-damage-in-hairless-mice
#11
Yang Hee Hong, Hyun-Sun Lee, Eun Young Jung, Sung-Hee Han, Yooheon Park, Hyung Joo Suh
BACKGROUND: Abnormal activation of matrix metalloproteinases (MMPs) plays an important role in UV-induced wrinkle formation, which is a major dermatological problem. This formation occurs due to the degeneration of the extracellular matrix (ECM). In this study, we investigated the cutaneous photoprotective effects of Ultraflo L treated ginseng leaf (UTGL) in hairless mice. METHODS: SKH-1 hairless mice (6 weeks of age) were randomly divided into four groups (8 mice/group)...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29019108/molecular-modeling-elucidates-the-cellular-mechanism-of-synaptotagmin-snare-inhibition-a-novel-plausible-route-to-anti-wrinkle-activity-of-botox-like-cosmetic-active-molecules
#12
Pathomwat Wongrattanakamon, Piyarat Nimmanpipug, Busaban Sirithunyalug, Supat Jiranusornkul
Synaptotagmin 1 (Syt1) is the Ca(2+) sensor protein with an essential role in neurotransmitter release. Since the wrinkle formation is due to the excessive muscle fiber stimulation in the face, a helpful stratagem to diminish the wrinkle line intenseness is to weaken the innervating neuron activity through Syt1 inhibition which is one of the possible therapeutic strategies against wrinkles. Recently, experimental evidence showed that botox-like peptides, which are typically used as SNARE modulators, may inhibit Syt1...
October 10, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29018860/competitive-concurrence-of-surface-wrinkling-and-dewetting-of-liquid-crystalline-polymer-films-on-non-wettable-substrates
#13
Sung E Song, Gwan H Choi, Gi-Ra Yi, Pil J Yoo
Polymeric thin films coated on non-wettable substrates undergo film-instabilities, which are usually manifested as surface deformation in the form of dewetting or wrinkling. The former takes place in fluidic films, whereas the latter occurs in solid films. Therefore, there have rarely been reports of systems involving simultaneous deformations of dewetting and wrinkling. In this study, we propose polymeric thin films of liquid crystalline (LC) mesogens prepared on a non-wettable Si substrate and apply a treatment of plasma irradiation to form a thin polymerized layer at the surface...
October 11, 2017: Soft Matter
https://www.readbyqxmd.com/read/29018455/seed-nutrition-and-quality-seed-coat-boron-and-lignin-are-influenced-by-delayed-harvest-in-exotically-derived-soybean-breeding-lines-under-high-heat
#14
Nacer Bellaloui, James R Smith, Alemu Mengistu
The timing of harvest is a major factor affecting seed quality in soybean, particularly in Midsouthern USA, when rain during harvest period is not uncommon. The objective of this research was to evaluate the effects of time of harvest on soybean seed quality (seed composition, germination, seed coat boron, and lignin) in high germinability (HG) breeding lines (50% exotic) developed under high heat. The hypothesis was that seeds of HG lines possess physiological and genetic traits for a better seed quality at harvest maturity and delayed harvest...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28994699/fisetin-regulates-nrf2-expression-and-the-inflammation-related-signaling-pathway-to-prevent-uvb-induced-skin-damage-in-hairless-mice
#15
Po-Yuan Wu, Jia-Ling Lyu, Yi-Jung Liu, Ting-Yi Chien, Hao-Cheng Hsu, Kuo-Ching Wen, Hsiu-Mei Chiang
Chronic ultraviolet (UV) exposure may cause skin damage, disrupt skin barrier function, and promote wrinkle formation. UV induces oxidative stress and inflammation, which results in extracellular matrix degradation in the dermis and epidermal hyperplasia. Our previous study demonstrated that fisetin exerts photoprotective activity by inhibiting mitogen-activated protein kinase/activator protein-1/matrix metalloproteinases (MMPs) activation. In this study, fisetin was applied topically to investigate its antiphotodamage effects in hairless mice...
October 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28991394/wrinkled-2d-materials-a-versatile-platform-for-low-threshold-stretchable-random-lasers
#16
Han-Wen Hu, Golam Haider, Yu-Ming Liao, Pradip Kumar Roy, Rini Ravindranath, Huan-Tsung Chang, Cheng-Hsin Lu, Chang-Yang Tseng, Tai-Yung Lin, Wei-Heng Shih, Yang-Fang Chen
A stretchable, flexible, and bendable random laser system capable of lasing in a wide range of spectrum will have many potential applications in next- generation technologies, such as visible-spectrum communication, superbright solid-state lighting, biomedical studies, fluorescence, etc. However, producing an appropriate cavity for such a wide spectral range remains a challenge owing to the rigidity of the resonator for the generation of coherent loops. 2D materials with wrinkled structures exhibit superior advantages of high stretchability and a suitable matrix for photon trapping in between the hill and valley geometries compared to their flat counterparts...
October 9, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28990118/efficacy-of-long-pulse-nd-yag-laser-versus-fractional-er-yag-laser-in-the-treatment-of-hand-wrinkles
#17
Reza M Robati, Elmira Asadi, Anoosh Shafiee, Nastaran Namazi, Atefeh Talebi
There are different modalities for hand rejuvenation. Fractional Er:YAG laser and long pulse Nd:YAG laser were introduced for treating hand wrinkles. We plan to compare fractional Er:YAG laser and long pulse Nd:YAG laser in a randomized controlled double-blind design with multiple sessions and larger sample size in comparison with previous studies. Thirty-three participants with hand wrinkles entered this study. They were randomly allocated to undergo three monthly laser treatments on each hand, one with a fractional Er:YAG laser and the other with a long pulse Nd:YAG laser...
October 8, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28989963/ultrathin-thermoresponsive-self-folding-3d-graphene
#18
Weinan Xu, Zhao Qin, Chun-Teh Chen, Hye Rin Kwag, Qinli Ma, Anjishnu Sarkar, Markus J Buehler, David H Gracias
Graphene and other two-dimensional materials have unique physical and chemical properties of broad relevance. It has been suggested that the transformation of these atomically planar materials to three-dimensional (3D) geometries by bending, wrinkling, or folding could significantly alter their properties and lead to novel structures and devices with compact form factors, but strategies to enable this shape change remain limited. We report a benign thermally responsive method to fold and unfold monolayer graphene into predesigned, ordered 3D structures...
October 2017: Science Advances
https://www.readbyqxmd.com/read/28989048/supraorbital-keyhole-approach-to-the-sella-and-anterior-skull-base-via-a-forehead-wrinkle-incision
#19
Jin Xiao, Weihong Wang, Xianxiang Wang, Zhongxiang Mao, Hao Qi, Hongwei Cheng, Yongqiang Yu
OBJECTIVE: The aim of this study was to evaluate the safety and effectiveness of the supraorbital keyhole approach to the sella and anterior skull base via a forehead wrinkle incision. METHODS: We analyzed and reclassified the forehead wrinkle types in 100 recruited healthy individuals. Twenty selected patients with different intracranial lesions in the sella and anterior skull base areas were selected for surgery using the supraorbital keyhole approach via a forehead wrinkle incision by types...
October 5, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28987023/efficacy-and-safety-of-a-novel-soluble-microneedle-patch-for-the-improvement-of-facial-wrinkle
#20
Ji Yeon Hong, Eun Jung Ko, Sun Young Choi, Kapsok Li, A Reum Kim, Jin O Park, Beom Joon Kim
BACKGROUND: Various kinds of functional cosmetics are on the market, although there are a variety of opinions concerning the actual effect. Transdermal microneedle patch has been introduced as a newly developed device for drug delivery through the skin. OBJECTIVE: This study was conducted to verify the face skin improvement effect and safety of a novel cosmetic microneedle patch. METHODS: A total of 84 Korean females finished this prospective clinical trial...
October 7, 2017: Journal of Cosmetic Dermatology
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