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Ji-Hyeon Choi, Min-Ju Seo, Kyung-Chul Shin, Ki Won Lee, Deok-Kun Oh
20(S)-Protopanaxadiol (APPD) has potential uses in the pharmaceutical, cosmetic, and food industries because of its anti-stress, anti-fatigue, anti-cancer, anti-inflammatory, and anti-wrinkle properties. However, APPD production is difficult because β-glycosidases that convert the protopanaxadiol (PPD)-type ginsenoside compound K to APPD are rare. β-Glycosidase from Dictyoglomus turgidum (DT-bgl) has the highest specific activity for converting compound K to APPD, but exhibits no activity towards the α-L-arabinopyranoside moiety in compound Y...
December 14, 2017: AMB Express
Kuniko Kadoya, Elizabeth T Makino, Lily I Jiang, Michael Bachelor, Robin Chung, Priscilla Tan, Tsing Cheng, Gail K Naughton, Rahul C Mehta
<p>Skin care products may use various active ingredients to support skin rejuvenation including growth factors and other molecules that help to regenerate extracellular matrix (ECM) and promote skin repair. The biological effect of skin care products with a strong anti-aging claim was assessed in gene expression analyses using an in vitro human skin model. Application of products containing human fbroblast-derived growth factors resulted in signifcant upregulation of genes encoding ECM components including collagens and elas-tin...
December 1, 2017: Journal of Drugs in Dermatology: JDD
Jarel K Gandhi, Zahid Manzar, Lori A Bachman, Cynthia Andrews-Pfannkoch, Travis Knudsen, Matthew Hill, Hannah Schmidt, Raymond Iezzi, Jose S Pulido, Alan D Marmorstein
Recent phase 1 trials of embryonic stem cell and induced pluripotent stem cell (iPSCs) derived RPE transplants for the treatment of macular degeneration have demonstrated the relative safety of this process. However, there is concern over clumping, thickening, folding, and wrinkling of the transplanted RPE. To deliver a flat RPE monolayer, current phase 1 trials are testing synthetic substrates for RPE transplantation. These substrates, however, cause localized inflammation and fibrosis in animal models due to long degradation times...
December 9, 2017: Acta Biomaterialia
Liu Cui, Sanqiang Shi, Gaosheng Wei, Xiaoze Du
Graphene-based materials exhibit intriguing phononic and thermal properties. In this paper, we have investigated the heat conductance in graphene sheets under shear-strain-induced wrinkling deformation, using equilibrium molecular dynamics simulations. A significant orientation dependence of the thermal conductivity of graphene wrinkles (GWs) is observed. The directional dependence of the thermal conductivity of GWs stems from the anisotropy of phonon group velocities as revealed by the G-band broadening of the phonon density of states (DOS), the anisotropy of thermal resistance as evidenced by the G-band peak mismatch of the phonon DOS, and the anisotropy of phonon relaxation times as a direct result of the double-exponential-fitting of the heat current autocorrelation function...
December 12, 2017: Physical Chemistry Chemical Physics: PCCP
Imke Göllner, Werner Voss, Ulrike von Hehn, Susanne Kammerer
Intake of oral supplements with the aim of a cutaneous antiaging effect are increasingly common. Hyaluronic acid (HA) is a promising candidate, as it is the key factor for preserving tissue hydration. In our practice study, we evaluated the effect of an oral HA preparation diluted in a cascade-fermented organic whole food concentrate supplemented with biotin, vitamin C, copper, and zinc (Regulatpro Hyaluron) on skin moisture content, elasticity, skin roughness, and wrinkle depths. Twenty female subjects with healthy skin in the age group of 45 to 60 years took the product once daily for 40 days...
January 1, 2017: Journal of Evidence-based Complementary & Alternative Medicine
P Nardinocchi, E Puntel
Gels are widely employed in smart mechanical devices and biomedical applications. Swelling-induced bending actuation can be obtained by means of a simple bilayer gel beam. We show that this system can also exhibit wrinkling patterns of potential interest for structural morphing and sensing. We study swelling-induced wrinkling at the extrados of a bilayer gel beam with the softer layer on top. The bent configuration at finite strain is recovered first and, starting from it, a linear perturbation analysis is performed...
November 2017: Proceedings. Mathematical, Physical, and Engineering Sciences
Kohei Okamoto, Haruhiko Yasumuro, Akira Mori, Yuzuru Ikeda
Cephalopods are able to control their arms sophisticatedly and use them for various behaviors, such as camouflage, startling predators and hunting prey. Here, we report a previously undescribed arm-flapping behavior of the pharaoh cuttlefish, Sepia pharaonis, observed in captivity. S. pharaonis raised the first pair of arms and wrinkled the parts near the distal end, where the skin color was darkened. Additionally, S. pharaonis spread the second and third pairs of arms and bent them as if they were jointed, and flapped the distal ends...
2017: Journal of Ethology
Jingjing Chen, Zhiyong Mao, Lexi Zhang, Dajian Wang, Ran Xu, Lijian Bie, Bradley D Fahlman
Graphitic carbon nitride (g-C3N4) behaving as a layered feature with graphite was indexed as a high-content nitrogen-doping carbon material, attracting increasing attention for application in energy storage devices. However, poor conductivity and resulting serious irreversible capacity loss were pronounced for g-C3N4 material due to its high nitrogen content. In this work, magnesiothermic denitriding technology is demonstrated to reduce the nitrogen content of g-C3N4 (especially graphitic nitrogen) for enhanced lithium storage properties as lithium ion battery anodes...
December 12, 2017: ACS Nano
Jingzhi Hu, Tong Li, Bingqing Wei
The electrochemical-mechanical coupling property of solid electrolyte membranes is critical to improving the performance of solid-state energy storage devices. A new phenomenon was observed that the electrochemical charge-discharge process induced aligned wrinkles on the edge of PVA-H2SO4 gel polymer electrolytes (GPEs), which is attributed to the deformation of polymer chains under electrochemical stimulation according to multiscale simulations. In the reversed direction, by means of modeling and testing, it was proved that the ionic conductivity of GPE can be tuned by mediating the mechanical properties of GPEs via tailoring the polymer at the nanoscale...
December 6, 2017: Journal of Physical Chemistry Letters
Jia-Sheng Sun, Jin-Wu Jiang, Harold S Park, Sulin Zhang
Two-dimensional (2D) layered crystals are prone to bending and folding owing to their ultra-low bending stiffness. Folds are traditionally viewed as defects that degrade the material performance. Here, we demonstrate that folds and cohesive forces in 2D layered crystals like graphene and MoS2 can be exploited to collect and clean up interlayer impurities, wherein multiple separated impurities agglomerate into a single, large cluster. We combine classical molecular dynamics simulations and an analytical model to elucidate the competing roles of membrane bending and impurity-membrane cohesive energies in the self-cleaning process...
December 6, 2017: Nanoscale
Jaehyun Han, Jun-Young Lee, Jihye Lee, Jong-Souk Yeo
A highly stretchable and reliable, transparent and conductive entangled graphene mesh network (EGMN) exhibits an interconnected percolation network, as usually shown in 1D nanowires, but with the electrical, mechanical, and thermal properties of 2D graphene. The unique combination of the 2D material properties and the network structure of wrinkled, waved, and crumpled graphene enables the EGMN to demonstrate excellent electrical reliability, mechanical durability, and thermal stability, even under harsh environmental and external conditions such as very high temperature, humidity, bending, and stretching...
December 4, 2017: Advanced Materials
Jeong-Min Ha, Cho-Ah Lim, Kyuboem Han, Jong-Cheon Ha, Hae-Eul Lee, Young Lee, Young-Joon Seo, Chang-Deok Kim, Jeung-Hoon Lee, Myung Im
[This corrects the article on p. 187 in vol. 29, PMID: 28392646.].
December 2017: Annals of Dermatology
Namrita Lall, Navneet Kishore, Bianca Fibrich, Isa Anina Lambrechts
Background: Myrsine africana (MA) is a plant traditionally used in South Africa to treat various diseases. Objective: The ethanolic extract of MA, was used for in vitro and in vivo studies to determine its elastase inhibitory activity. Materials and Methods: MA and its isolated compound, myrsinoside B, were tested in vitro for their elastase inhibitory activity. The MA extract was also evaluated for mutagenicity using two strains of Salmonella typhimurium (TA 98 and TA 100), microbial count, metal analysis, and stability...
October 2017: Pharmacognosy Magazine
Sinan Li, Shaobin Yang, Ding Shen, Wen Sun, Xueying Shan, Wei Dong, Yuehui Chen, Xu Zhang, Yongqiang Mao, Shuwei Tang
Lithium-sulfur (Li-S) batteries have attracted increasing attention due to their high theoretical capacity, being a promising candidate for portable electronics, electric vehicles and large-scale energy storage. The interactions of bilayer structured graphitic C3N4 (bi-C3N4) with S8, lithium polysulfides (LiPSs), 1,3-dioxolane, 1,2-dimethoxyethane and tetrahydrofuran ether-based solvents have been studied using first-principles calculations. It has been found that the (micropore-scale) interlayer of bi-C3N4 shows intimate contact and strong binding with S8 and LiPSs due to the formation of chemical Li-N bonds...
December 4, 2017: Physical Chemistry Chemical Physics: PCCP
Qi-Hui Zhu, Zhong-Kai Zhou, Dan-Dan Tu, Yi-Lian Zhou, Cong Wang, Ze-Peng Liu, Wen-Bin Gu, Yu-Yin Chen, Miao-An Shu
Cadmium (Cd) is a heavy metal that accumulates easily in organisms and causes several detrimental effects, including tissue damage. Cd contamination from anthropogenic terrestrial sources flows into rivers, and through estuaries to the ocean. To evaluate the toxic effects of Cd on estuary crustaceans, we exposed the mud crab Scylla paramamosain to various Cd concentrations (0, 10.0, 20.0, and 40.0mg/L) for 24h. We also exposed mud crabs to a fixed Cd concentration (20.0mg/L) for various periods of time (0, 6, 12, 24, 48, and 72h)...
November 30, 2017: Aquatic Toxicology
Xia Li, Mohamed A Shenashen, Xiupeng Wang, Atsuo Ito, Akiyoshi Taniguchi, Sherif A Ei-Safty
Alum is the only licensed adjuvant by Food and Drug Administration of USA used in many human vaccines and has excellent safety record in clinical applications. However, alum hardly induces T helper 1 (Th1) immune responses that are required for anti-tumor immunity. In the present study, we fabricated hierarchical copper- and zinc- buds dressing γ-AlOOH mesostrands (Cu- and Zn-AMSs) with randomly wrinkled morphology, mesoscale void- or cave-like pockets, high-exposed surface coverage sites, and positive charge streams in saline...
December 1, 2017: Scientific Reports
Angela C Mora Huertas, Christian E H Schmelzer, Chiara Luise, Wolfgang Sippl, Markus Pietzsch, Wolfgang Hoehenwarter, Andrea Heinz
Neprilysin is also known as skin fibroblast-derived elastase, and its up-regulation during aging is associated with impairments of the elastic fiber network, loss of skin elasticity and wrinkle formation. However, information on its elastase activity is still limited. The aim of this study was to investigate the degradation of fibrillar skin elastin by neprilysin and the influence of the donor's age on the degradation process using mass spectrometry and bioinformatics approaches. The results showed that cleavage by neprilysin is dependent on previous damage of elastin...
November 28, 2017: Biochimie
Saurabh Shah, Soon-Keong Chew
BACKGROUND: Skin hyperpigmentation is the darkening of skin due to the increased production of melanin in the body. OBJECTIVES: To evaluate the efficacy and safety of a botanical-based Rosa E pigmentation serum in healthy fair skin female volunteers with wrinkles, skin tone, and pigmentation. METHODS: This was a single-arm, open label study conducted in healthy Indian females; 18 subjects aged 30-55, having fair Caucasian-like skin with at least 2 dark skin pigments with facial wrinkles diagnosed by dermatologist were selected...
November 28, 2017: Journal of Cosmetic Dermatology
Bing Deng, Zhenqian Pang, Shulin Chen, Xin Li, Caixia Meng, Jiayu Li, Mengxi Liu, Juanxia Wu, Yue Qi, Wenhui Dang, Hao Yang, Yanfeng Zhang, Jin Zhang, Ning Kang, H Q Xu, Qiang Fu, Xiaohui Qiu, Peng Gao, Yujie Wei, Zhongfan Liu, Hailin Peng
Wrinkles are ubiquitous for graphene films grown on various substrates by chemical vapor deposition (CVD) at high temperature due to the strain induced by thermal mismatch between the graphene and substrates, which greatly degrade the extraordinary properties of graphene. Here we show that the wrinkle formation of graphene grown on Cu substrates is strongly dependent on the crystallographic orientations. Wrinkle-free single-crystal graphene was grown on a wafer-scale twin-boundary-free single-crystal Cu(111) thin film fabricated on sapphire substrate through the strain engineering...
November 30, 2017: ACS Nano
Min Zuo, Yu Dong, Degang Zhao, Yan Wang, Xinying Teng
In this article, the anti-poison performance of novel Al-6Y-2P master alloy for impurity Ca in hypereutectic Al-Si alloys was investigated in detail. According to the microstructural analysis, it can be found that the primary Si and eutectic Si particles could be relatively modified and refined. In order to investigate the influence mechanism of Ca on the limited refinement performance of Al-6Y-2P master alloy, types of Al-xSi-2Ca-3Y-1P (x = 0, 6, 12, 18, and 30) alloys were prepared. It is observed that Ca takes the form of more stable Ca3P2 compounds by reacting with YP, and the surface of Ca3P2 particles are unsmooth, and even some have wrinkles in Al Al-2Ca-3Y-1P alloy...
November 26, 2017: Materials
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