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Dynamic contrast imaging

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https://www.readbyqxmd.com/read/28811568/dynamic-x-ray-radiography-reveals-particle-size-and-shape-orientation-fields-during-granular-flow
#1
François Guillard, Benjy Marks, Itai Einav
When granular materials flow, the constituent particles segregate by size and align by shape. The impacts of these changes in fabric on the flow itself are not well understood, and thus novel non-invasive means are needed to observe the interior of the material. Here, we propose a new experimental technique using dynamic X-ray radiography to make such measurements possible. The technique is based on Fourier transformation to extract spatiotemporal fields of internal particle size and shape orientation distributions during flow, in addition to complementary measurements of velocity fields through image correlation...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28810793/image-method-for-electrostatic-energy-of-polarizable-dipolar-spheres
#2
Kyle S Gustafson, Guoxi Xu, Karl F Freed, Jian Qin
The multiple-scattering theory for the electrostatics of many-body systems of monopolar spherical particles, embedded in a dielectric medium, is generalized to describe the electrostatics of these particles with embedded dipoles and multipoles. The Neumann image line construction for the electrostatic polarization produced by one particle is generalized to compute the energy, forces, and torques for the many-body system as functions of the positions of the particles. The approach is validated by comparison with direct numerical calculation, and the convergence rate is analyzed and expressed in terms of the discontinuity in dielectric contrast and particle density...
August 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28809731/the-histopathological-features-and-ct-mri-imaging-performances-in-hepatic-angiomyolipoma-patients
#3
Huiguo Ding, Hongtao Wei, Hui Liu, Yuhan Chen, Xiaowei Xue, Honglei Weng
AIM: To evaluate the diagnostic value of dynamic contrast-enhanced computed tomography (CT) and magnetic resonance imaging (MRI) in the differential diagnosis of hepatic angiomyolipoma (HAML) and hepatocellular carcinoma (HCC) and to clarify the relationship between histopathological features and CT or MRI imaging performances in HAML. MATERIAL AND METHODS: Six HAML and 33 non-cirrhotic HCC patients confirmed by histopathology were retrospectively analyzed. The serum biomarkers, CT and MRI examinations were conventionally performed before the confirmatory histological diagnosis...
August 8, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28809018/fluorescent-quail-a-transgenic-model-system-for-the-dynamic-study-of-avian-development
#4
David Huss, Rusty Lansford
Real-time four-dimensional (4D, xyzt) imaging of cultured avian embryos is an ideal method for investigating the complex movements of cells and tissues during early morphogenesis. While methods that transiently label cells, such as electroporation, are highly useful for dynamic imaging, they can also be limiting due to the number and type of cells that can be effectively targeted. In contrast, the heritable, stable, and long-term expression of a fluorescent protein driven by the exogenous promoter of a transgene overcomes these challenges...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28807036/t-time-a-data-repository-of-t-cell-and-calcium-release-activated-calcium-channel-activation-imagery
#5
Cody Arbuckle, Milton Greenberg, Adrienne Bergh, Rene German, Nick Sirago, Erik Linstead
BACKGROUND: A fundamental understanding of live-cell dynamics is necessary in order to advance scientific techniques and personalized medicine. For this understanding to be possible, image processing techniques, probes, tracking algorithms and many other methodologies must be improved. Currently there are no large open-source datasets containing live-cell imaging to act as a standard for the community. As a result, researchers cannot evaluate their methodologies on an independent benchmark or leverage such a dataset to formulate scientific questions...
August 15, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28806317/quantitative-evaluation-of-diffusion-and-dynamic-contrast-enhanced-magnetic-resonance-imaging-for-differentiation-between-primary-central-nervous-system-lymphoma-and-glioblastoma
#6
Shanshan Lu, Siqi Wang, Qianqian Gao, Minlin Zhou, Yang Li, Peng Cao, Xunning Hong, Haibin Shi
OBJECTIVE: This study aimed to evaluate the utility of diffusion and permeability parameters derived from diffusion-weighted imaging and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for differentiating primary central nervous system lymphoma (PCNSL) and glioblastoma multiforme (GBM) and to assess the correlation among these parameters. MATERIALS AND METHODS: Forty-two patients with GBM and 18 patients with PCNSL underwent conventional 3.0-T MRI, diffusion-weighted imaging, and DCE-MRI before surgery...
August 12, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28806062/exploring-strategies-for-labeling-viruses-with-gold-nanoclusters-through-non-equilibrium-molecular-dynamics-simulations
#7
Emmi Pohjolainen, Sami Malola, Gerrit Groenhof, Hannu Häkkinen
Bio-compatible gold nanoclusters can be utilized as contrast agents in virus imaging. The labeling of viruses can be achieved non-covalently but site-specifically by linking the cluster to the hydrophobic pocket of a virus via a lipid-like pocket factor. We have estimated the binding affinities of three different pocket factors of echovirus 1 (EV1) in molecular dynamics simulations combined with non-equilibrium free energy calculations. We have also studied the effects on binding affinities with a pocket factor linked to the Au102pMBA44 nanocluster in different protonation states...
August 14, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28805936/characterizing-hypoxia-in-human-glioma-a-simultaneous-multimodal-mri-and-pet-study
#8
Christine Preibisch, Kuangyu Shi, Anne Kluge, Mathias Lukas, Benedikt Wiestler, Jens Göttler, Jens Gempt, Florian Ringel, Mohamed Al Jaberi, Jürgen Schlegel, Bernhard Meyer, Claus Zimmer, Thomas Pyka, Stefan Förster
Hypoxia plays an important role for the prognosis and therapy response of cancer. Thus, hypoxia imaging would be a valuable tool for pre-therapeutic assessment of tumor malignancy. However, there is no standard validated technique for clinical application available yet. Therefore, we performed a study in 12 patients with high-grade glioma, where we directly compared the two currently most promising techniques, namely the MR-based relative oxygen extraction fraction (MR-rOEF) and the PET hypoxia marker H-1-(3-[(18) F]-fluoro-2-hydroxypropyl)-2-nitroimidazole ([(18) F]-FMISO)...
August 14, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28804704/hypoxia-in-cervical-cancer-from-biology-to-imaging
#9
REVIEW
Heidi Lyng, Eirik Malinen
PURPOSE: Hypoxia imaging may improve identification of cervical cancer patients at risk of treatment failure and be utilized in treatment planning and monitoring, but its clinical potential is far from fully realized. Here, we briefly describe the biology of hypoxia in cervix tumors of relevance for imaging, and evaluate positron emission tomography (PET) and magnetic resonance imaging (MRI) techniques that have shown promise for assessing hypoxia in a clinical setting. We further discuss emerging imaging approaches, and how imaging can play a role in future treatment strategies to target hypoxia...
2017: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28803622/effect-of-hyoscine-butylbromide-on-prostate-multiparametric-mri-anatomical-and-functional-image-quality
#10
R A Slough, I Caglic, N L Hansen, A J Patterson, T Barrett
AIM: To evaluate the effect of the spasmolytic agent hyoscine butylbromide (HBB) on the quality of anatomical and functional imaging of the prostate. MATERIALS AND METHODS: One hundred and seventy-three patients were included in this retrospective study. Eighty-seven patients received intravenous HBB prior to scanning (HBB group) and 86 patients did not (non-HBB group). Multiparametric (mp) 3 T magnetic resonance imaging (MRI) was performed using a 32-channel body coil...
August 10, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28803216/3d-2d-registration-with-superabundant-vessel-reconstruction-for-cardiac-resynchronization-therapy
#11
Daniel Toth, Maria Panayiotou, Alexander Brost, Jonathan M Behar, Christopher A Rinaldi, Kawal S Rhode, Peter Mountney
A key component of image guided interventions is the registration of preoperative and intraoperative images. Classical registration approaches rely on cross-modality information; however, in modalities such as MRI and X-ray there may not be sufficient cross-modality information. This paper proposes a fundamentally different registration approach which uses adjacent anatomical structures with superabundant vessel reconstruction and dynamic outlier rejection. In the targeted clinical scenario of cardiac resynchronization therapy (CRT) delivery, preoperative, non contrast-enhanced, MRI is registered to intraoperative, contrasted X-ray fluoroscopy...
August 5, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28802567/nano-sized-and-other-improved-reporters-for-magnetic-resonance-imaging-of-angiogenesis
#12
Simonetta Geninatti Crich, Enzo Terreno, Silvio Aime
Magnetic Resonance Imaging (MRI) enables to provide anatomical, functional and molecular information of pathological angiogenesis when used with properly tailored imaging probes. Functional studies have been the domain of Dynamic Contrast Enhancement (DCE) -MRI protocols from which it is possible to extract quantitative estimations on key parameters such as the volumes of vascular and extracellular compartments and the rates of the bidirectional exchange of the imaging reporters across the endothelial barrier...
August 9, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28802145/ensemble-of-expert-deep-neural-networks-for-spatio-temporal-denoising-of-contrast-enhanced-mri-sequences
#13
A Benou, R Veksler, A Friedman, T Riklin Raviv
Dynamic contrast-enhanced MRI (DCE-MRI) is an imaging protocol where MRI scans are acquired repetitively throughout the injection of a contrast agent. The analysis of dynamic scans is widely used for the detection and quantification of blood-brain barrier (BBB) permeability. Extraction of the pharmacokinetic (PK) parameters from the DCE-MRI concentration curves allows quantitative assessment of the integrity of the BBB functionality. However, curve fitting required for the analysis of DCE-MRI data is error-prone as the dynamic scans are subject to non-white, spatially-dependent and anisotropic noise...
August 2, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28801894/increased-apical-rotation-in-patients-with-severe-aortic-stenosis-assessed-by-three-dimensional-speckle-tracking-imaging
#14
Maidar Tumenbayar, Kazuto Yamaguchi, Hiroyuki Yoshitomi, Akihiro Endo, Kazuaki Tanabe
BACKGROUND: Two-dimensional (2D) speckle tracking imaging (STI) is a non-invasive method used to assess subtle changes in left ventricular (LV) function such as strain and rotational dynamics. However, 2D methodology is complicated by issues such as the out-of-plane problem inherent in short-axis imaging. In addition, circumferential rotation contributes to three-dimensional (3D) wall deformations and affects tracking accuracy. By using 3D-STI technique, we evaluated LV global longitudinal strain (GLS) and apical rotation in severe aortic stenosis (AS) patients with preserved LV ejection fraction (EF)...
August 11, 2017: Journal of Echocardiography
https://www.readbyqxmd.com/read/28797238/with-a-biomechanical-treatment-in-knee-osteoarthritis-less-knee-pain-did-not-correlate-with-synovitis-reduction
#15
Vikram Swaminathan, Matthew J Parkes, Michael J Callaghan, Terence W O'Neill, Richard Hodgson, Andrew D Gait, David T Felson
BACKGROUND: Braces are used to treat pain in patellofemoral joint osteoarthritis (PFJOA). In a trial, we previously reported pain improvement after 6-weeks brace use. The pain reduction did not correlate with changes in Magnetic Resonance Imaging (MRI) assessed Bone Marrow Lesion volume or static synovial volume. Studies show that changes in the synovium on dynamic contrast enhanced (DCE) MRI are more closely associated with symptom change than static synovial volume changes. We hypothesised change in synovitis assessed using dynamic imaging could explain the reduction in pain...
August 10, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28796620/transport-of-liposome-encapsulated-drugs-in-voxelized-computational-model-of-human-brain-tumors
#16
A Bhandari, A Bansal, A Singh, N Sinha
There are many obstacles to transport of chemotherapeutic drugs to tumor cells that lead to irregular and non-uniform uptake of drugs inside tumors. Study of these transport problems will help in accurate prediction of drug transport and optimizing treatment strategy. To this end, liposome mediated drug delivery has emerged as an excellent anticancer therapy due to its ability to deliver drugs at site of action and reducing the chances of side effects to the healthy tissues. In this study, a computational fluid dynamics (CFD) model based on realistic vasculature of human brain tumor is presented...
August 7, 2017: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/28795734/single-gold-bipyramids-with-sharp-tips-as-sensitive-single-particle-orientation-sensors-in-biological-studies
#17
So Young Lee, Yeji Han, Jong Wook Hong, Ji Won Ha
Plasmonic gold bipyramids (AuBPs) with sharp tips are promising orientation probes in biological studies because of their anisotropic shape, strong electric field enhancement at the tips, and convenient manipulation into other shapes. Herein, we elucidate the optical properties of single AuBPs at their localized surface plasmon resonance (LSPR) wavelengths using dark-field (DF) microscopy and differential interference contrast (DIC) microscopy and test their use as orientation probes in a dynamic biological environment...
August 10, 2017: Nanoscale
https://www.readbyqxmd.com/read/28794472/high-resolution-transport-of-intensity-quantitative-phase-microscopy-with-annular-illumination
#18
Chao Zuo, Jiasong Sun, Jiaji Li, Jialin Zhang, Anand Asundi, Qian Chen
For quantitative phase imaging (QPI) based on transport-of-intensity equation (TIE), partially coherent illumination provides speckle-free imaging, compatibility with brightfield microscopy, and transverse resolution beyond coherent diffraction limit. Unfortunately, in a conventional microscope with circular illumination aperture, partial coherence tends to diminish the phase contrast, exacerbating the inherent noise-to-resolution tradeoff in TIE imaging, resulting in strong low-frequency artifacts and compromised imaging resolution...
August 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28794138/quantitative-assessment-of-coronary-microvascular-function-dynamic-single-photon-emission-computed-tomography-positron-emission-tomography-ultrasound-computed-tomography-and-magnetic-resonance-imaging
#19
Attila Feher, Albert J Sinusas
A healthy, functional microcirculation in combination with nonobstructed epicardial coronary arteries is the prerequisite of normal myocardial perfusion. Quantitative assessment in myocardial perfusion and determination of absolute myocardial blood flow can be achieved noninvasively using dynamic imaging with multiple imaging modalities. Extensive evidence supports the clinical value of noninvasively assessing indices of coronary flow for diagnosing coronary microvascular dysfunction; in certain diseases, the degree of coronary microvascular impairment carries important prognostic relevance...
August 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28793277/o-2-18-f-fluoroethyl-l-tyrosine-18-f-fet-uptake-in-insulinoma-first-results-from-a-xenograft-mouse-model-and-from-human
#20
Alessio Imperiale, Frédéric Boisson, Guillaume Kreutter, Bernard Goichot, Izzie Jacques Namer, Philippe Bachellier, Patrice Laquerriere, Laurence Kessler, Patrice Marchand, David Brasse
INTRODUCTION: Herein we have evaluated the uptake of O-(2-(18)F-fluoroethyl)-l-tyrosine ((18)F-FET) in insulinoma in comparison with those of 6-(18)F-fluoro-3,4-dihydroxy-l-phenylalanine ((18)F-FDOPA) providing first data from both murine xenograft model and one patient with proved endogenous hyperinsulinemic hypoglycemia. METHODS: Dynamic (18)F-FET and carbidopa-assisted (18)F-FDOPA PET were performed on tumor-bearing nude mice after subcutaneous injection of RIN-m5F murine beta cells and on a 30-year-old man with type-1 multiple endocrine neoplasia and hyperinsulinemic hypoglycemia defined by a positive fasting test...
July 12, 2017: Nuclear Medicine and Biology
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