HaoSheng Sun, Jennifer A Martin, Craig T Werner, Zi-Jun Wang, Diane M Damez-Werno, Kimberly N Scobie, Ning-Yi Shao, Caroline Dias, Jacqui Rabkin, Ja Wook Koo, Amy M Gancarz, Ezekiell A Mouzon, Rachael L Neve, Li Shen, David M Dietz, Eric J Nestler
UNLABELLED: ATP-dependent chromatin remodeling proteins are being implicated increasingly in the regulation of complex behaviors, including models of several psychiatric disorders. Here, we demonstrate that Baz1b, an accessory subunit of the ISWI family of chromatin remodeling complexes, is upregulated in the nucleus accumbens (NAc), a key brain reward region, in both chronic cocaine-treated mice and mice that are resilient to chronic social defeat stress. In contrast, no regulation is seen in mice that are susceptible to this chronic stress...
April 6, 2016: Journal of Neuroscience