keyword
https://read.qxmd.com/read/38536762/the-impact-of-musculoskeletal-ill-health-on-quality-of-life-and-function-after-critical-care-a-multicentre-prospective-cohort-study
#1
JOURNAL ARTICLE
O D Gustafson, E B King, M M Schlussel, A Arnold, C Wade, P S Nicol, M J Rowland, H Dawes, M A Williams
Physical disability is a common component of post-intensive care syndrome, but the importance of musculoskeletal health in this population is currently unknown. We aimed to determine the musculoskeletal health state of intensive care unit survivors and assess its relationship with health-related quality of life; employment; and psychological and physical function. We conducted a multicentre prospective cohort study of adults admitted to intensive care for > 48 h without musculoskeletal trauma or neurological insult...
March 27, 2024: Anaesthesia
https://read.qxmd.com/read/38535823/paradoxical-exception-to-island-tameness-increased-defensiveness-in-an-insular-population-of-rattlesnakes
#2
JOURNAL ARTICLE
William K Hayes, Carl E Person, Gerad A Fox, Julie L King, Erick Briggs, Eric C K Gren
Island tameness results largely from a lack of natural predators. Because some insular rattlesnake populations lack functional rattles, presumably the consequence of relaxed selection from reduced predation, we hypothesized that the Santa Catalina Island, California, USA, population of the southern Pacific rattlesnake ( Crotalus helleri , which possesses a functional rattle), would exhibit a decrement in defensive behavior relative to their mainland counterparts. Contrary to our prediction, rattlesnakes from the island not only lacked tameness compared to mainland snakes, but instead exhibited measurably greater levels of defensiveness...
March 18, 2024: Toxins
https://read.qxmd.com/read/38534088/cdc-funded-hiv-testing-and-undiagnosed-hiv-infection-in-ending-the-hiv-epidemic-in-the-u-s-jurisdictions
#3
JOURNAL ARTICLE
Deesha Patel, Weston O Williams, Carolyn Wright, Aba Essuon, Guoshen Wang, Mesfin S Mulatu
BACKGROUND: Approximately 13% of persons with HIV (PWH) are unaware of their status. To help end HIV, it is important to understand the relationship between the rates of HIV testing and undiagnosed HIV infection. SETTING: Ending the HIV in the U.S. (EHE) jurisdictions. METHODS: Using 2021 data from the National HIV Surveillance System and the National HIV Prevention Program Monitoring and Evaluation system, we calculated estimated rates of undiagnosed HIV infections per 100,000 population and rates of CDC-funded HIV tests per 1,000 population...
March 23, 2024: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://read.qxmd.com/read/38533951/impact-of-an-impaired-maternal-fetal-environment-on-death-in-children-with-congenital-heart-defects-undergoing-surgery-in-denmark-from-1994-to-2018
#4
JOURNAL ARTICLE
Rasmus Kristensen, Camilla Omann, Charlotte K Ekelund, J William Gaynor, Vibeke E Hjortdal
BACKGROUND: Studies show that an impaired maternal-fetal environment (iMFE) increases the mortality risk in children with single-ventricle congenital heart defects (CHDs). We investigated the impact of an iMFE on death in children with various surgically corrected CHDs. METHODS AND RESULTS: In this nationwide register-based study, we examined the association between an iMFE (including preeclampsia, gestational hypertension, gestational diabetes, maternal smoking during pregnancy) and death in a large cohort of children with surgically corrected CHDs in Denmark (1994-2018)...
March 27, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38531290/lemmel-s-syndrome-case-report-of-a-not-feasible-endoscopic-management
#5
William Sergi, Annarita Libia, Elisa Stasi, Norma Depalma, Stefano D'Ugo, Marcello Spampinato
INTRODUCTION: Lemmel's syndrome is a rare disease presenting with obstructive jaundice, secondary to common bile duct compression by duodenal diverticulum. PRESENTATION OF CASE: A 79-year-old female was admitted to our emergency department with cholangitis and obstructive jaundice, due to choledocal compression by two periampullary diverticula, with major papilla opening near the biggest one (periampullary diverticulum type III). Endoscopic retrograde cholangiopancreatography didn't succeed sphincterotomy, therefore laparoscopic rendez-vous was performed...
March 11, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38531023/a-validated-highly-sensitive-microsatellite-instability-assay-accurately-identifies-individuals-harboring-biallelic-germline-pms2-pathogenic-variants-in-constitutional-mismatch-repair-deficiency
#6
JOURNAL ARTICLE
Fátima Marín, Júlia Canet-Hermida, Vanessa Bianchi, Jiil Chung, Katharina Wimmer, William Foulkes, Vanesa Pérez-Alonso, Nerea Domínguez-Pinilla, Constantino Sábado, Felisa Vázquez-Gómez, Antonio Molinés, Victoria Fioravantti, Estela Carrasco, Lucie Stengs, Melissa Edwards, Logine Negm, Anirban Das, Melyssa Aronson, Ángela Pastor, Daniel Rueda, Luis Ignacio González-Granado, Uri Tabori, Gabriel Capellá, Marta Pineda
BACKGROUND: Constitutional mismatch repair deficiency (CMMRD) is a rare and extraordinarily penetrant childhood-onset cancer predisposition syndrome. Genetic diagnosis is often hampered by the identification of mismatch repair (MMR) variants of unknown significance and difficulties in PMS2 analysis, the most frequently mutated gene in CMMRD. We present the validation of a robust functional tool for CMMRD diagnosis and the characterization of microsatellite instability (MSI) patterns in blood and tumors...
March 26, 2024: Clinical Chemistry
https://read.qxmd.com/read/38527600/prediction-of-metabolic-syndrome-following-a-first-pregnancy
#7
JOURNAL ARTICLE
Tetsuya Kawakita, Philip Greenland, Victoria L Pemberton, William A Grobman, Robert M Silver, C Noel Bairey Merz, Rebecca B McNeil, David M Haas, Uma M Reddy, Hyagriv Simhan, George R Saade
BACKGROUND: The prevalence of metabolic syndrome is rapidly increasing in the United States. We hypothesized that prediction models using data obtained during pregnancy can accurately predict the future development of metabolic syndrome. OBJECTIVE: To develop machine-learning models to predict the development of metabolic syndrome using factors ascertained in nulliparous pregnant individuals. STUDY DESIGN: This was a secondary analysis of a prospective cohort study (Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be Heart Health Study [nuMoM2b HHS])...
March 23, 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38523848/a-rare-case-of-persistent-multifocal-cribriform-morular-thyroid-carcinoma
#8
William Kuenstner, Po Zhao, Wen Lee, Carlos Garcia, Kenneth D Burman, Leila Shobab
BACKGROUND/OBJECTIVE: Cribriform-morular thyroid carcinoma (CMTC) was considered a variant of papillary thyroid carcinoma (PTC) but is a separate entity in the 2022 World Health Organization classification. CMTC has an association with familial adenomatous polyposis (FAP). Our objective is to report a case of CMTC who was subsequently diagnosed with FAP, to highlight these associated entities and implications for management. CASE REPORT: A 15-year-old female with a history of iron-deficiency anemia and alpha-gal syndrome presented with several years of goiter and dysphagia...
2024: AACE Clinical Case Reports
https://read.qxmd.com/read/38522849/natural-history-of-clonal-haematopoiesis-seen-in-real-world-haematology-settings
#9
JOURNAL ARTICLE
Shyam A Patel, William K Gerber, Rena Zheng, Shrinkhala Khanna, Lloyd Hutchinson, Gregory A Abel, Jan Cerny, Brandon A DaSilva, Tian Y Zhang, Muthalagu Ramanathan, Salwa Khedr, William Selove, Bruce Woda, Patricia M Miron, Anne W Higgins, Jonathan M Gerber
Recursive partitioning of healthy consortia led to the development of the Clonal Hematopoiesis Risk Score (CHRS) for clonal haematopoiesis (CH); however, in the practical setting, most cases of CH are diagnosed after patients present with cytopenias or related symptoms. To address this real-world population, we characterize the clinical trajectories of 94 patients with CH and distinguish CH harbouring canonical DNMT3A/TET2/ASXL1 mutations alone ('sole DTA') versus all other groups ('non-sole DTA'). TET2, rather than DNMT3A, was the most prevalent mutation in the real-world setting...
March 24, 2024: British Journal of Haematology
https://read.qxmd.com/read/38520374/neurocognitive-impairment-in-post-covid-19-condition-in-adults-narrative-review-of-the-current-literature
#10
JOURNAL ARTICLE
William Garmoe, Kavitha Rao, Bethany Gorter, Rachel Kantor
The severe acute respiratory syndrome coronavirus 2 virus has, up to the time of this article, resulted in >770 million cases of COVID-19 illness worldwide, and approximately 7 million deaths, including >1.1 million in the United States. Although defined as a respiratory virus, early in the pandemic, it became apparent that considerable numbers of people recovering from COVID-19 illness experienced persistence or new onset of multi-system health problems, including neurologic and cognitive and behavioral health concerns...
March 22, 2024: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://read.qxmd.com/read/38515336/tuberculosis-preventive-treatment-uptake-among-adults-living-with-human-immunodeficiency-virus-analysis-of-zimbabwe-population-based-human-immunodeficiency-virus-impact-assessment-2020
#11
JOURNAL ARTICLE
Talent Maphosa, Kelsey Mirkovic, Rachel A Weber, Godfrey Musuka, Munyaradzi P Mapingure, Julia Ershova, Rebecca Laws, Trudy Dobbs, William Coggin, Charles Sandy, Tsitsi Apollo, Owen Mugurungi, Michael Melchior, Mansoor S Farahani
BACKGROUND: Tuberculosis remains the leading cause of death by an infectious disease among people living with HIV (PLHIV). TB Preventive Treatment (TPT) is a cost-effective intervention known to reduce morbidity and mortality. We used data from ZIMPHIA 2020 to assess TPT uptake and factors associated with its use. METHODOLOGY: ZIMPHIA a cross-sectional household survey, estimated HIV treatment outcomes among PLHIV aged ≥15 years. Randomly selected participants provided demographic and clinical information...
March 22, 2024: International Journal of STD & AIDS
https://read.qxmd.com/read/38514468/suppression-of-host-humoral-immunity-by-borrelia-burgdorferi-varies-over-the-course-of-infection
#12
JOURNAL ARTICLE
Megan T Williams, Yan Zhang, Mark E Pulse, Rance E Berg, Michael S Allen
Borrelia burgdorferi , the spirochetal agent of Lyme disease, utilizes a variety of strategies to evade and suppress the host immune response, which enables it to chronically persist in the host. The resulting immune response is characterized by unusually strong IgM production and a lack of long-term protective immunity. Previous studies in mice have shown that infection with B. burgdorferi also broadly suppresses host antibody responses against unrelated antigens. Here, we show that mice infected with B. burgdorferi and concomitantly immunized with recombinant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein had an abrogated antibody response to the immunization...
March 22, 2024: Infection and Immunity
https://read.qxmd.com/read/38514158/flecainide-causing-elevated-capture-thresholds-on-pacemaker-implantation
#13
JOURNAL ARTICLE
Kevin Chee-Theng Leow, Wooi Ye Lim, Audrey Lee, Moyazur Rahman, Ren Tan
Flecainide is a Vaughan Williams class 1c antiarrhythmic used to treat supraventricular and ventricular arrhythmias. It has been described as a rare cause for increased pacemaker capture thresholds. We describe a report of a patient, in her early 80s, presenting with tachy-brady syndrome on a background of permanent atrial fibrillation. She was treated with metoprolol and flecainide by her private cardiologist. Permanent right ventricular chamber pacing was recommended for her slow heart rate. At insertion of her single chamber pacemaker, she was noted to have elevated capture thresholds despite appropriate lead positioning...
March 21, 2024: BMJ Case Reports
https://read.qxmd.com/read/38508719/prevalence-of-lung-cysts-in-adolescents-and-adults-with-a-germline-dicer1-pathogenic-likely-pathogenic-variant-a-report-from-the-national-institutes-of-health-and-international-pleuropulmonary-blastoma-dicer1-registry
#14
JOURNAL ARTICLE
Alexander T Nelson, Lauren M Vasta, Dave Watson, Jung Kim, Anne K Harris, Ana F Best, Laura A Harney, Ann G Carr, Nicole Frederickson, Louis P Dehner, Christian P Kratz, Kelly N Hagedorn, William A Mize, Alexander Ling, Yoav H Messinger, D Ashley Hill, Kris Ann P Schultz, Douglas R Stewart
BACKGROUND: Pleuropulmonary blastoma (PPB), the hallmark tumour associated with DICER1 -related tumour predisposition, is characterised by an age-related progression from a cystic lesion (type I) to a high-grade sarcoma with mixed cystic and solid features (type II) or purely solid lesion (type III). Not all cystic PPBs progress; type Ir (regressed), hypothesised to represent regressed or non-progressed type I PPB, is an air-filled, cystic lesion lacking a primitive sarcomatous component...
March 20, 2024: Thorax
https://read.qxmd.com/read/38508486/ex-vivo-lung-perfusion-in-donation-after-circulatory-death-a-post-hoc-analysis-of-the-novel-trial
#15
JOURNAL ARTICLE
Doug A Gouchoe, Pablo G Sanchez, Jonathan D'Cunha, Christian A Bermudez, Mani A Daneshmand, Robert D Davis, Matthew G Hartwig, Thomas C Wozniak, Zachary N Kon, Bartley P Griffith, William R Lynch, Tiago N Machuca, Michael J Weyant, Michael E Jessen, Michael S Mulligan, Frank D'Ovidio, Phillip C Camp, Edward Cantu, Bryan A Whitson
OBJECTIVE: Donation after circulatory death (DCD) donors offer the ability to expand the lung donor pool and ex vivo lung perfusion (EVLP) further contributes to this ability by allowing for additional evaluation and resuscitation of these extended criteria donors. We sought to determine the outcomes of recipients receiving organs from DCD EVLP donors in a multi-center setting. METHODS: This was an unplanned post-hoc analysis of a multicenter, prospective, non-randomized trial that took place in 2011-2017 with 3-years of follow up...
March 18, 2024: Journal of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/38508476/transcriptomic-analysis-reveals-mitochondrial-dysfunction-in-the-pathogenesis-of-nager-syndrome-in-sf3b4-depleted-zebrafish
#16
JOURNAL ARTICLE
Zulvikar Syambani Ulhaq, William Ka Fai Tse
Nager syndrome (NS) is a rare acrofacial dysostosis caused by heterozygous loss-of-function variants in the splicing factor 3B subunit 4 (SF3B4). The main clinical features of patients with NS are characterized by facial-mandibular and preaxial limb malformations. The migration and specification of neural crest cells are crucial for craniofacial development, and mitochondrial fitness appears to play a role in such processes. Here, by analyzing our previously published transcriptome dataset, we aim to investigate the potential involvement of mitochondrial components in the pathogenesis of craniofacial malformations, especially in sf3b4 mutant zebrafish...
March 18, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease
https://read.qxmd.com/read/38502911/withdrawal-catastrophizing-scale-initial-psychometric-properties-and-implications-for-the-study-of-opioid-use-disorder-and-hyperkatifeia
#17
JOURNAL ARTICLE
Orman Trent Hall, Michael Vilensky, Julie E Teater, Craig Bryan, Kara Rood, Julie Niedermier, Parker Entrup, Stephanie Gorka, Anthony King, David A Williams, K Luan Phan
Background: Discovery of modifiable factors influencing subjective withdrawal experience might advance opioid use disorder (OUD) research and precision treatment. This study explores one factor - withdrawal catastrophizing - a negative cognitive and emotional orientation toward withdrawal characterized by excessive fear, worry or inability to divert attention from withdrawal symptoms. Objectives: We define a novel concept - withdrawal catastrophizing - and present an initial evaluation of the Withdrawal Catastrophizing Scale (WCS)...
March 19, 2024: American Journal of Drug and Alcohol Abuse
https://read.qxmd.com/read/38500774/high-sars-cov-2-attack-rates-in-areas-with-low-detection-after-community-transmission-established-in-port-vila-vanuatu-april-2022
#18
JOURNAL ARTICLE
Florita Toa, Wendy Williams, Chaturangi Yapa, Matthew Cornish, Melissa Binihi, Caroline van Gemert
OBJECTIVE: On 4 March 2022, the first community-acquired case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported in Vanuatu, with community transmission occurring subsequently. It was expected that the number of notified SARS-CoV-2 cases would be an underestimate of the true infection rate of this outbreak; however, the magnitude of underreporting was unknown. The purpose of this study was to provide a population-based estimate of SARS-CoV-2 infection shortly after the first reports of community transmission, to understand the level of underdetection and undernotification in Vanuatu and thus to inform ongoing prevention and response activities...
2024: Western Pacific Surveillance and Response Journal: WPSAR
https://read.qxmd.com/read/38499023/the-impact-of-active-chest-tube-clearance-technology-on-surgical-outcomes-after-cardiac-surgery-an-updated-systematic-review-and-meta-analysis
#19
REVIEW
Basil Ahmad, Vithusha Yogathasan, Eric Meng, William Khoury, Ali Alakhtar, Angel-Luis Fernandez, Mohammad El-Diasty
OBJECTIVE: Active chest tube clearance technology (ACT) systems were introduced to improve the patency of chest tubes and to reduce the potential complications associated with inadequate mediastinal blood drainage after cardiac surgical procedures. The purpose of this study is to assess the impact of ACT on the incidence of chest tube clogging, retained blood syndromes (RBS), re-exploration for bleeding, and the incidence of postoperative atrial fibrillation (POAF) after cardiac surgical procedures...
October 11, 2023: Port J Card Thorac Vasc Surg
https://read.qxmd.com/read/38498685/lower-urinary-tract-symptoms-in-a-prospective-cohort-of-covid-19-survivors
#20
JOURNAL ARTICLE
Cristiano M Gomes, Marcelo Hisano, Julia D Souza, João Victor T Henriques, Jose de Bessa, Julyana Moromizato, Thulio Bosi, Rachel Mazoni, João Gismondi, Bruno Camargo, Zein M Sammour, Homero Bruschini, Linamara R Battistella, William C Nahas
PURPOSE: To analyze the prevalence of lower urinary tract symptoms (LUTS) in patients who survived moderate and severe forms of COVID-19 and the risk factors for LUTS six months after hospitalization. MATERIALS AND METHODS: In this prospective cohort study, patients were evaluated six months after hospitalization due to COVID-19. LUTS were assessed using the International Prostate Symptom Score. General health was assessed through the Hospital Anxiety and Depression Scale and the EQ5D-L5 scale, which evaluates mobility, ability to perform daily activities, pain and discomfort and completed a self-perception health evaluation...
March 3, 2024: International Braz J Urol: Official Journal of the Brazilian Society of Urology
keyword
keyword
74483
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.