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https://www.readbyqxmd.com/read/29020956/guaiphenesin-ketamine-xylazine-infusion-to-maintain-anesthesia-in-mules-undergoing-field-castration
#1
Cecilia Vullo, Augusto Carluccio, Domenico Robbe, Marina Meligrana, Linda Petrucci, Giuseppe Catone
BACKGROUND: In order to determine whether a combination of guaiphenesin, ketamine and xylazine can induce safe and satisfactory anaesthesia in mules undergoing field castration, eight healthy adult intact male mules were employed. They were premedicated with intravenous (IV) xylazine (1.3 mg/kg); an additional dose of xylazine (0.3 mg/kg IV) was administered in case of inadequate depth of sedation. Anaesthesia was induced with IV thiopental (6 mg/kg). The quality of sedation and induction was recorded...
October 11, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28982208/comparing-pathological-complete-response-rate-using-oral-capecitabine-versus-infusional-5-fluorouracil-with-preoperative-radiotherapy-in-rectal-cancer-treatment
#2
Narotam Jootun, Tess Evans, Jackie Mak, Greg Makin, Cameron Platell
BACKGROUND: Infusional 5-fluorouracil (5-FU) has been the standard radiation sensitizer in patients undergoing preoperative long-course chemoradiotherapy (CRT) for locally advanced rectal cancer in Australia. Capecitabine (Xeloda) is an oral 5-FU prodrug of comparable pharmacodynamic activity, currently preferred in place of 5-FU infusion, its established counterpart in neoadjuvant CRT for rectal cancer. The few studies quantifying pathological complete response (pCR) of Xeloda versus 5-FU have produced inconsistent results...
October 5, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28970803/high-frequency-stimulation-of-the-pelvic-nerve-inhibits-urinary-voiding-in-anesthetized-rats
#3
Jonathan J Crook, Thelma A Lovick
Urge Urinary Incontinence: "a sudden and uncontrollable desire to void which is impossible to defer" is extremely common and considered the most bothersome of lower urinary tract conditions. Current treatments rely on pharmacological, neuromodulatory, and neurotoxicological approaches to manage the disorder, by reducing the excitability of the bladder muscle. However, some patients remain refractory to treatment. An alternative approach would be to temporarily suppress activity of the micturition control circuitry at the time of need i...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28947986/preoperative-short-vs-long-course-chemoradiotherapy-with-delayed-surgery-for-locally-advanced-rectal-cancer
#4
Mi Joo Chung, Dong Wook Kim, Weon Kuu Chung, Suk Hwan Lee, Seung-Kyu Jeong, Jae Kwan Hwang, Choon Sik Jeong
PURPOSE: To compare the clinical outcomes between short-course chemoradiotherapy (CRT) and long-course CRT with delayed surgery in locally advanced rectal cancer patients. RESULTS: From 2010 to 2015, 19 patients were treated with short-course CRT and 53 patients were treated with LCRT. The sphincter-saving rate (89.5% vs. 94.3%, short-course CRT vs. long-course CRT), pathologic complete remission (21.1% vs. 13.2%), downstaging (47.4% vs. 26.4%), and treatment complications including anastomotic site leakage, bowel adhesion, and hematologic toxicity associated with short-course CRT were not significantly different from those associated with long-course CRT...
September 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28928554/study-to-compare-the-effect-of-oral-rectal-and-intravenous-infusion-of-paracetamol-for-postoperative-analgesia-in-women-undergoing-cesarean-section-under-spinal-anesthesia
#5
Lakshmi Mahajan, Vaishali Mittal, Ruchi Gupta, Himani Chhabra, Jyoti Vidhan, Ashreen Kaur
BACKGROUND: Effective pain relief therapy after caesarean section is essential for the parturient's comfort and early ambulation. Paracetamol has an excellent safety profile when compared to opioids. AIM: To assess and evaluate the effect of oral, rectal, and intravenous infusion of paracetamol for post-operative analgesia in women undergoing caesarean section under spinal anaesthesia. SETTINGS AND DESIGN: We conducted a prospective, randomized controlled study (18-35 years of age) of the ASA- I and II parturient scheduled for lower segment caesarean section were included...
July 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28780040/long-term-direct-visualization-of-passively-transferred-fluorophore-conjugated-antibodies
#6
Jeffrey R Schneider, Ann M Carias, Arangaserry R Bastian, Gianguido C Cianci, Patrick F Kiser, Ronald S Veazey, Thomas J Hope
The use of therapeutic antibodies, delivered by intravenous (IV) instillation, is a rapidly expanding area of biomedical treatment for a variety of conditions. However, little is known about how the antibodies are anatomically distributed following infusion and the underlying mechanism mediating therapeutic antibody distribution to specific anatomical sites remains to be elucidated. Current efforts utilize low resolution and sensitivity methods such as ELISA and indirect labeling imaging techniques, which often leads to high background and difficulty in assessing biodistribution...
November 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/28763330/a-phase-i-clinical-trial-of-the-phosphatidylserine-targeting-antibody-bavituximab-in-combination-with-radiation-therapy-and-capecitabine-in-the-preoperative-treatment-of-rectal-adenocarcinoma
#7
Jeffrey Meyer, Yull Arriaga, Joselin Anandam, Sirisha Karri, Samira Syed, Udit Verma, Abier Abdelnaby, Grace Raja, Ying Dong, Muhammad Beg, Glen Balch
OBJECTIVES: There is interest in improving the tumoricidal effects of preoperative radiotherapy for rectal carcinoma by studying new radiosensitizers. The safety and toxicity profile of these combination regimens needs rigorous clinical evaluation. The primary objective of this study was to evaluate the toxicity of combining bavituximab, an antibody that targets exposed phosphatidylserine, with capecitabine and radiation therapy. MATERIALS AND METHODS: Patients with stage II or III rectal adenocarcinoma were enrolled on a phase I study combining radiation therapy, capecitabine, and bavituximab...
July 31, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28697127/celecoxib-oral-administration-for-prevention-of-post-endoscopic-retrograde-cholangiopancreatography-pancreatitis-a-randomized-prospective-trial
#8
Kunihiro Kato, Masatsugu Shiba, Yuki Kakiya, Hirotsugu Maruyama, Masaki Ominami, Shusei Fukunaga, Satoshi Sugimori, Yasuaki Nagami, Toshio Watanabe, Kazunari Tominaga, Yasuhiro Fujiwara
OBJECTIVES: Rectal nonsteroidal anti-inflammatory drugs have reported promising prophylactic activity in post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). Conversely, cyclooxygenase-2 enzyme has been suggested to contribute to experimental acute pancreatitis. The aim of this study was to evaluate the efficacy of oral administration of celecoxib, a cyclooxygenase-2 inhibitor, for the prevention of PEP. METHODS: We performed a prospective randomized controlled study...
August 2017: Pancreas
https://www.readbyqxmd.com/read/28688514/pain-control-with-continuous-infusion-preperitoneal-wound-catheters-versus-continuous-epidural-analgesia-in-colon-and-rectal-surgery-a-randomized-controlled-trial
#9
Nicolas J Mouawad, Stefan W Leichtle, Christodoulos Kaoutzanis, Kathleen Welch, Suzanne Winter, Richard Lampman, Matt McCord, Kimberly A Hoskins, Robert K Cleary
OBJECTIVE: To compare continuous infusion preperitoneal wound catheters (CPA) versus continuous epidural analgesia (CEA) after elective colorectal surgery. METHODS: An open-label equivalence trial randomizing patients to CPA or CEA. Primary outcomes were postoperative pain as determined by numeric pain scores and supplemental narcotic analgesia requirements. Secondary outcomes included incidence of complications and patient health status measured with the SF-36 Health Survey (Acute Form)...
July 1, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28684965/documentation-of-herbal-medicines-used-for-the-treatment-and-management-of-human-diseases-by-some-communities-in-southern-ghana
#10
Augustine A Boadu, Alex Asase
Traditional medicine is an important component of the health care system of most developing countries. However, indigenous knowledge about herbal medicines of many Ghanaian cultures has not yet been investigated. The aim of the present study was to document herbal medicines used by traditional healers to treat and manage human diseases and ailments by some communities living in Ghana. The study was conducted in eight communities in southern Ghana. Data were collected from 45 healers using ethnobotanical questionnaire and voucher specimens were collected...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28663644/comparison-of-intravenous-infusion-of-tramadol-alone-with-combination-of-tramadol-and-paracetamol-for-postoperative-pain-after-major-abdominal-surgery-in-children
#11
Shayesta Ali, Khalid Sofi, Abdul Qayoom Dar
BACKGROUND: Pain is a common complaint after surgery and seems to be difficult to manage in children because of fear of complications of pain treatment or misconception that infants and small children do not feel pain at all or feel less pain. A survey reported that 40% of pediatric surgical patients experienced moderate or severe postoperative pain and that more than 75% had insufficient analgesia. Our study was carried to provide continuous infusion of intravenous (i.v.) tramadol alone using a dedicated infusion device Graseby 2100 syringe pump and compared it to a combination of i...
April 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28587389/comparison-of-the-hemodynamics-and-dynamics-of-fluid-shift-of-ringer-s-solution-before-surgery-in-children-and-adults
#12
Guizhou Zhu, Yuhong Li, Guomei Ru, Qiannan Ding
The present study investigated the hemodynamics, vascular and extravascular volume expansion induced by infusion of lactated Ringer's solution in children and adults before surgery. This was a prospective randomized double-blind study. A total of 28 patients (14 children and 14 adult patients; American Society of Anesthesiology status I) scheduled for similar minor pelvic, anal rectal or lower limb surgery were recruited for the present study. All patients were administered with 10 ml/kg of lactated Ringer's solution at a constant rate over 20 min...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28551665/the-role-of-concomitant-radiation-boost-in-neoadjuvant-chemoradiotherapy-for-locally-advanced-rectal-cancer
#13
Harun Badakhshi, Mahmoud Ismail, Christos Boskos, Kuaile Zhao, David Kaul
BACKGROUND/AIM: This study analyzed the impact of concomitant boost on long-term clinical outcomes in locally advanced rectal cancer. PATIENTS AND METHODS: A total of 141 patients (median age=61 years) were treated with neoadjuvant chemoradiotherapy. Median total dose was 50.4 Gy. Forty-three patients received a concomitant boost. Concurrent chemotherapy consisted of 5-fluorouracil (5-FU), given as a 24-h continuous infusion. Mean follow-up was 83.7 months. RESULTS: The 3, 5-, and 10-year overall survival (OS) rates were 91...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28539646/colonic-infusions-of-short-chain-fatty-acid-mixtures-promote-energy-metabolism-in-overweight-obese-men-a-randomized-crossover-trial
#14
Emanuel E Canfora, Christina M van der Beek, Johan W E Jocken, Gijs H Goossens, Jens J Holst, Steven W M Olde Damink, Kaatje Lenaerts, Cornelis H C Dejong, Ellen E Blaak
Short-chain fatty acids (SCFA), formed by microbial fermentation, are believed to be involved in the aetiology of obesity and diabetes. This study investigated the effects of colonic administration of physiologically relevant SCFA mixtures on human substrate and energy metabolism. In this randomized, double-blind, crossover study, twelve normoglycaemic men (BMI 25-35 kg/m(2)) underwent four investigational days, during which SCFA mixtures (200 mmol/L) high in either acetate (HA), propionate (HP), butyrate (HB) or placebo (PLA) were rectally administered during fasting and postprandial conditions (oral glucose load)...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28533798/optimal-bladder-filling-during-high-dose-rate-intracavitary-brachytherapy-for-cervical-cancer-a-dosimetric-study
#15
Umesh Mahantshetty, Saurabha Shetty, Dipanjan Majumder, Pranjal Adurkar, Jamema Swamidas, Reena Engineer, Supriya Chopra, Shyamkishore Shrivastava
PURPOSE: The aim of this study is to compare 3D dose volume histogram (DVH) parameters of bladder and other organs at risk with different bladder filling protocol during high-dose-rate intracavitary brachytherapy (HDR-ICBT) in cervical cancer, and to find optimized bladder volume. MATERIAL AND METHODS: This dosimetric study was completed with 21 patients who underwent HDR-ICBT with computed tomography/magnetic resonance compatible applicator as a routine treatment...
April 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28514978/jugular-infused-methionine-lysine-and-branched-chain-amino-acids-does-not-improve-milk-production-in-holstein-cows-experiencing-heat-stress
#16
K R Kassube, J D Kaufman, K G Pohler, J W McFadden, A G Ríus
Poor utilization of amino acids contributes to losses of milk protein yield in dairy cows exposed to heat stress (HS). Our objective was to test the effect of essential amino acids on milk production in lactating dairy cows exposed to short-term HS conditions. To achieve this objective, 12 multiparous, lactating Holstein cows were assigned to two environments (thermoneutral (THN) or HS) from days 1 to 14 in a split-plot type cross-over design. All cows received 0 g/day of essential amino acids from days 1 to 7 (negative control (NC)) followed by an intravenous infusion of l-methionine (12 g/day), l-lysine (21 g/day), l-leucine (35 g/day), l-isoleucine (15 g/day) and l-valine (15 g/day, methionine, lysine and branched-chain amino acids (ML+BCAA)) from days 8 to 14...
May 18, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28484158/adult-t-cell-leukemia-lymphoma-complicated-by-takotsubo-cardiomyopathy-and-htlv-1-associated-myelopathy-after-treatment-with-the-anti-ccr4-antibody-mogamulizumab
#17
Satoshi Yamanaka, Kazutaka Nakayama, Hayato Tamai, Masanori Sakamaki, Koiti Inokuchi
Adult T-cell leukemia-lymphoma (ATL) caused by human T-lymphotropic virus type 1 (HTLV-1) is generally associated with poor prognosis. The anti-CCR4 antibody mogamulizumab is one of the options for refractory or relapsed ATL. Mogamulizumab is intravenously administered as a single agent at a dose of 1.0 mg/kg once a week for 8 weeks. The overall response rate is reported to be 50%. Reported common adverse events after administration of mogamulizumab are leukocytopenia, infusion reaction, and skin rash. Although rare, mogamulizumab-associated cardiomyopathy has also been reported...
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/28481175/dosimetric-evaluation-of-a-flexible-dual-balloon-constructed-applicator-in-treating-anorectal-cancer
#18
Hsiang-Chi Kuo, Keyur J Mehta, Ravindra Yaparpalvi, Alan Lee, Dinesh Mynampati, William Bodner, Madhur Garg, David Huang, Wolfgang A Tomé, Shalom Kalnicki
BACKGROUND AND PURPOSE: To assess the dosimetric flexibility of a dual balloon brachytherapy applicator developed for the treatment of anorectal lesions. MATERIALS AND METHODS: Different amounts of water were infused into the inner and outer balloon separately to study the asymmetrical distribution of the catheter, the radial distance of the active source channel to the inner surface of the global target volume , the space between the active source channels, and their dosimetric impact to target tissues and uninvolved rectum...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28464105/effects-of-dexamethasone-treatment-and-respiratory-vaccination-on-rectal-temperature-complete-blood-count-and-functional-capacities-of-neutrophils-in-beef-steers
#19
H D Hughes, J A Carroll, N C Burdick Sanchez, S L Roberts, P R Broadway, N D May, M A Ballou, J T Richeson
The objective of this research was to examine the effects of dexamethasone (DEX) treatment on various aspects of immunity following administration of a multivalent respiratory vaccine, using a model intended to mimic acute versus chronic stress. Angus × Hereford steers ( = 32; 209 ± 8 kg) were stratified by BW and randomly assigned to 1 of 3 treatments: 1) acute stress (ACU), in which 0.5 mg/kg BW DEX was intravenously administered at 1000 h only on d 0; 2) chronic stress (CHR), in which 0.5 mg/kg BW DEX was intravenously administered at 1000 h on d -3 to 0; or 3) control (CON), in which no DEX was administered...
April 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28435398/the-changes-of-tumour-vascular-endothelial-growth-factor-expression-after-neoadjuvant-chemoradiation-in-patients-with-rectal-adenocarcinoma
#20
David Buka, Josef Dvorak, Veronika Sitorova, Igor Sirak, Rene Voboril, Bohuslav Melichar, Igor Richter
AIM OF THE STUDY: The aim was to examine the effects of neoadjuvant chemoradiotherapy on VEGF expression in patients with locally advanced rectal cancer. MATERIALS AND METHODS: A total of 53 patients with locally advanced rectal cancer were retrospectively studied. Neoadjuvant treatment comprised external beam radiation (50.4 Gy/28 fractions) with continuous infusion of 5-fluorouracil. Four to 6 weeks after the chemoradiotherapy, the patients underwent surgical resection...
2017: Contemporary Oncology Współczesna Onkologia
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