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https://www.readbyqxmd.com/read/27898958/technical-note-a-procedure-to-estimate-glucose-requirements-of-an-activated-immune-system-in-steers
#1
S K Kvidera, E A Horst, M Abuajamieh, E J Mayorga, M V Sanz Fernandez, L H Baumgard
: Infection and inflammation impede efficient animal productivity. The activated immune system ostensibly requires large amounts of energy and nutrients otherwise destined for synthesis of agriculturally relevant products. Accurately determining the immune system's in vivo energy needs is difficult, but a better understanding may facilitate developing nutritional strategies to maximize productivity. The study objective was to estimate immune system glucose requirements following an i...
November 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27816497/lactated-ringer-s-solution-in-combination-with-rectal-indomethacin-for-prevention-of-post-ercp-pancreatitis-and-readmission-a-prospective-randomized-double-blinded-placebo-controlled-trial
#2
Shaffer R S Mok, Henry C Ho, Paurush Shah, Milan Patel, John P Gaughan, Adam B Elfant
BACKGROUND AND AIMS: Prospective data have shown the benefit of rectal indomethacin (IND) for preventing post-ERCP pancreatitis (PEP). A recent pilot study demonstrated a lower incidence of PEP after an 8-hour lactated ringer's (LR) infusion. The aim of this study was to evaluate the efficacy of IND with or without bolus LR in patients at high-risk for PEP. METHODS: In this randomized, double-blinded, placebo-controlled trial we assigned patients to standard normal saline solution (NS)+placebo, NS+IND, LR+placebo or LR+IND...
November 2, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27752600/a-survey-based-study-on-the-protocols-for-therapeutic-hypothermia-in-cardiac-arrest-patients-in-korea-focusing-on-the-differences-between-level-1-and-2-centers
#3
Tae Gwan Oh, Won Chul Cha, Ik Joon Jo, Mun Ju Kang, Dong Woo Lee
OBJECTIVE: We aimed to summarize the therapeutic hypothermia (TH) protocols used in emergency departments (EDs) in Korea and to investigate the differences between level 1 and 2 centers. METHODS: The chief residents from 56 EDs were given a structured survey containing questions on the indications for TH, methods for TH induction, maintaining, and finalizing TH treatments. The participants were divided into 2 groups based on their work place (level 1 vs. level 2 centers)...
December 2015: Clinical and Experimental Emergency Medicine
https://www.readbyqxmd.com/read/27659363/liberal-perioperative-fluid-administration-is-an-independent-risk-factor-for-morbidity-and-is-associated-with-longer-hospital-stay-after-rectal-cancer-surgery
#4
M R Boland, I Reynolds, N McCawley, E Galvin, S El-Masry, J Deasy, D A McNamara
INTRODUCTION Recent studies have advocated the use of perioperative fluid restriction in patients undergoing major abdominal surgery as part of an enhanced recovery protocol. Series reported to date include a heterogenous group of high- and low-risk procedures but few studies have focused on rectal cancer surgery alone. The aim of this study was to assess the effects of perioperative fluid volumes on outcomes in patients undergoing elective rectal cancer resection. METHODS A prospectively maintained database of patients with rectal cancer who underwent elective surgery over a 2-year period was reviewed...
September 23, 2016: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/27651353/prophylaxis-of-pancreatitis-with-intravenous-ketoprofen-in-a-consecutive-population-of-ercp-patients-a-randomized-double-blind-placebo-controlled-trial
#5
Fernanda de Quadros Onófrio, Julio Carlos Pereira Lima, Guilherme Watte, Romnei Lenon Lehmen, Daniela Oba, Gabriela Camargo, Carlos Eduardo Oliveira Dos Santos
Background Acute pancreatitis is the most common complication after ERCP, occurring in about 4 % of the procedures. Only the placement of pancreatic duct prosthesis and the use of nonsteroidal anti-inflammatory drugs (NSAIDs) have shown benefit in the prevention of post-ERCP pancreatitis (PEP). Although the benefit of rectal administration of indomethacin or diclofenac is recommended by some studies and society guidelines especially in a selected group of high-risk patients, there is so far, no standardization of time or route of NSAID administration...
September 20, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27631775/acute-adverse-events-and-postoperative-complications-in-a-randomized-trial-of-preoperative-short-course-radiotherapy-versus-long-course-chemoradiotherapy-for-t3-adenocarcinoma-of-the-rectum-trans-tasman-radiation-oncology-group-trial-trog-01-04
#6
Nabila Ansari, Michael J Solomon, Richard J Fisher, John Mackay, Bryan Burmeister, Stephen Ackland, Alexander Heriot, David Joseph, Sue-Anne McLachlan, Bev McClure, Samuel Y Ngan
OBJECTIVE: To compare acute adverse events (AE) and postoperative complication rates in a randomized trial of short-course (SC) versus long-course (LC) preoperative radiotherapy. BACKGROUND: Evidence demonstrates that adding neoadjuvant radiotherapy to surgery offers better local control in the management of rectal cancer. With both SC and LC therapy there is a potential for acute treatment-related toxicity and increased patient morbidity. METHODS: Eligible patients had clinical-stage T3 rectal adenocarcinoma within 12 cm of the anal verge with no evidence of metastasis...
September 14, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27602924/impact-of-preoperative-radiotherapy-on-anastomotic-leakage-and-stenosis-after-rectal-cancer-resection-post-hoc-analysis-of-a-randomized-controlled-trial
#7
Qiyuan Qin, Tenghui Ma, Yanhong Deng, Jian Zheng, Zhiyang Zhou, Hui Wang, Lei Wang, Jianping Wang
BACKGROUND: Evidence regarding the effect of preoperative radiotherapy on anastomotic integrity remains conflicting in rectal cancer surgery. Prospective comparisons with appropriate controls are needed. OBJECTIVE: This study aimed to assess the impact of preoperative radiotherapy on anastomotic leakage and stenosis after rectal cancer resection. DESIGN: This was a post hoc analysis of a randomized controlled trial (NCT01211210). SETTINGS: Data were retrieved from the leading center of the trial, which is a tertiary hospital...
October 2016: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/27592442/clinical-response-after-chitosan-microparticle-administration-and-preliminary-assessment-of-efficacy-in-preventing-metritis-in-lactating-dairy-cows
#8
R Daetz, F Cunha, J H Bittar, C A Risco, F Magalhaes, Y Maeda, J E P Santos, K C Jeong, R F Cooke, K N Galvão
The objectives were to evaluate the clinical response to intrauterine administration of chitosan microparticles (CM) and to assess efficacy for preventing metritis in dairy cows. Holstein cows (n = 104; 40 primiparous and 64 multiparous) at increased risk for metritis (cows that had abortion, dystocia, twins, stillbirth, or retained placenta) were randomly assigned to 1 of 2 treatments at 1 d in milk (DIM; 24 h postpartum): CM group (n = 52), daily intrauterine infusion of 8 g of CM dissolved in 40 mL of sterile water for 5 d; control (CON) group (n = 52), daily intrauterine infusion of 40 mL of sterile water for 5 d...
August 31, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27567895/surviving-and-fatal-elephant-endotheliotropic-herpesvirus-1a-infections-in-juvenile-asian-elephants-lessons-learned-and-recommendations-on-anti-herpesviral-therapy
#9
Akbar Dastjerdi, Katharina Seilern-Moy, Karin Darpel, Falko Steinbach, Fieke Molenaar
BACKGROUND: Elephant Endotheliotropic Herpesviruses (EEHVs) can cause acute haemorrhagic disease in young Asian elephants (Elephas maximus) and clinical EEHV infections account for the majority of their fatalities. The anti-herpesviral drug famciclovir (FCV) has been used routinely to treat viraemic at-risk elephants, but thus far without proven efficacy. This paper presents clinical and virological investigations of two EEHV-1A infected elephants treated with FCV, and discusses anti-herpesvirus therapies of viraemic elephants...
2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27556283/a-comparative-study-of-strategies-for-prevention-of-post-ercp-pancreatitis-after-early-pre-cut-sphincterotomy-for-biliary-access
#10
Tiing Leong Ang, Andrew Boon Eu Kwek, Mingjun Song, James Weiquan Li, Prem Harichander Thurairajah
OBJECTIVES: Needle knife precut sphincterotomy (PS) during endoscopic retrograde cholangiopancreatography (ERCP) has been associated with a higher risk of post-ERCP pancreatitis (PEP). This study examined the effect of no prophylaxis, somatostatin, rectal diclofenac and pancreatic duct (PD) stenting in reducing the rates of PEP in patients who underwent early PS. METHODS: The study period was January 2006 to December 2015. A standardized approach to early PS was used: 1) inadvertent guidewire cannulation of PD > 3 times; 2) impacted bile duct stone; 3) inability to achieve deep cannulation within 10 minutes...
August 24, 2016: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27510001/outcomes-of-preoperative-chemoradiotherapy-and-combined-chemotherapy-with-radiotherapy-without-surgery-for-locally-advanced-rectal-cancer
#11
Chunsri Supaadirek, Montien Pesee, Komsan Thamronganantasakul, Pimsiree Thalangsri, Srichai Krusun, Narudom Supakalin
PURPOSE: To evaluate the treatment outcomes of patients with locally advanced rectal cancer treated with preoperative concurrent chemoradiotherapy (CCRT) or combined chemotherapy together with radiotherapy (CMTRT) without surgery. MATERIALS AND METHODS: A total of 84 patients with locally advanced rectal adenocarcinoma (stage II or III) between January 1st, 2003 and December 31st, 2013 were enrolled, 48 treated with preoperative CCRT (Gr.I) and 36 with combined chemotherapy and radiotherapy (CMTRT) without surgery (Gr...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27464408/midwifery-the-role-of-proctoclysis-rectal-fluid-infusion
#12
Annalee Reid
No abstract text is available yet for this article.
2016: Midwifery Today with International Midwife
https://www.readbyqxmd.com/read/27353093/-research-hotspot-and-progress-of-preoperative-chemoradiotherapy-for-rectal-cancer
#13
Jianhong Peng, Zhizhong Pan
Preoperative chemoradiotherapy (CRT) has become an important component of comprehensive treatment for rectal cancer. Although local recurrent risk has been remarkably reduced by CRT, distant metastasis remains the main cause of therapeutic failure. Therefore, more and more studies focused on controlling distant metastasis in order to prolong long-term survival. Recently, CRT has achieved certain progression in rectal cancer: (1)Patients with stage T3 should be classified into specific subgroups to formulate individualized treatment regimen...
June 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27351227/preoperative-short-vs-long-course-chemoradiotherapy-with-delayed-surgery-for-locally-advanced-rectal-cancer
#14
Mi Joo Chung, Dong Wook Kim, Weon Kuu Chung, Suk Hwan Lee, Seung-Kyu Jeong, Jae Kwan Hwang, Choon Sik Jeong
PURPOSE: To compare the clinical outcomes between short-course chemoradiotherapy (CRT) and long-course CRT with delayed surgery in locally advanced rectal cancer patients. RESULTS: From 2010 to 2015, 19 patients were treated with short-course CRT and 53 patients were treated with LCRT. The sphincter-saving rate (89.5% vs. 94.3%, short-course CRT vs. long-course CRT), pathologic complete remission (21.1% vs. 13.2%), downstaging (47.4% vs. 26.4%), and treatment complications including anastomotic site leakage, bowel adhesion, and hematologic toxicity associated with short-course CRT were not significantly different from those associated with long-course CRT...
June 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27320250/local-cerebral-hypothermia-induced-by-selective-infusion-of-cold-lactated-ringer-s-a-feasibility-study-in-rhesus-monkeys
#15
Bincheng Wang, Di Wu, David Dornbos Iii, Jingfei Shi, Yanhui Ma, Mo Zhang, Yumei Liu, Jian Chen, Yuchuan Ding, Yinghao Luo, Xunming Ji
BACKGROUND AND OBJECTIVE: Hypothermia has shown promise as a neuroprotective strategy for stroke. The use of whole body hypothermia has limited clinical utility due to many severe side effects. Selective brain cooling, or local brain hypothermia, has been previously proposed as an alternative treatment strategy. This study investigated the safety, feasibility, and efficacy of selective brain hypothermia induced by local infusion of ice-cold lactated Ringer's solution in rhesus monkeys...
June 2016: Neurological Research
https://www.readbyqxmd.com/read/27306776/predictors-of-pathologic-complete-response-after-preoperative-concurrent-chemoradiotherapy-of-rectal-cancer-a-single-center-experience
#16
Euncheol Choi, Jin Hee Kim, Ok Bae Kim, Mi Young Kim, Young Ki Oh, Sung Gyu Baek
PURPOSE: To identify possible predictors of pathologic complete response (pCR) of rectal cancer after preoperative concurrent chemoradiotherapy (CCRT). MATERIALS AND METHODS: We conducted a retrospective review of 53 patients with rectal cancer who underwent preoperative CCRT followed by radical surgery at a single center between January 2007 and December 2012. The median radiotherapy dose to the pelvis was 54.0 Gy (range, 45.0 to 63.0 Gy). Five-fluorouracil-based chemotherapy was administered via continuous infusion with leucovorin...
June 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27281724/in-plane-ultrasound-guided-lumbar-plexus-block-using-catheter-over-needle-technique-in-a-14-month-old-baby
#17
Andrea Tognù, Veronica Cauli, Nicola de Simone, Lucia Aurini, Marco Manfrini, Stefano Bonarelli
This case report details the feasibility of a continuous lumbar plexus block obtained with a paramedian transverse scan of the lumbar paravertebral region, using a catheter-over-needle system, as a main postoperative orthopedic analgesia, in a 14-month-old patient undergoing surgical treatment of a localized Ewing family tumor of the right proximal femur. After surgery, the patient remained in the intensive care unit for 3 days; pain was assessed regularly using the Children's and Infants' Postoperative Pain Scale, and comfort was monitored...
July 2016: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/27276074/-perioperative-management-of-pd-patients
#18
H Reichmann
Both patients and caregivers but also treating physicians are concerned about complications along with surgical interventions. A major problem is abrupt cessation of anti-Parkinson medication, which leads to manifold disturbances, sometimes even to an akinetic crisis. There are several means to guarantee continuous dopaminergic stimulation even in patients that are not allowed to take medication orally before they undergo surgery. Amongst others rectally applied levodopa, amantadine infusions, and especially the use of a rotigotine patch are good means to overcome oral intake...
July 2016: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/27261238/intravenous-lipid-emulsion-and-high-dose-insulin-as-adjunctive-therapy-for-propranolol-toxicity-in-a-pediatric-patient
#19
Amanda M Thompson, Carlos R Franco Palacios, Maria N Henriksen
PURPOSE: The concurrent use of intravenous lipid emulsion (ILE) and high-dose insulin (HDI) for the management and treatment of propranolol toxicity in a pediatric patient is described. SUMMARY: A seven-month-old infant (weight, 6.1 kg) was admitted to a hospital emergency department with lethargy and bradycardia after an unintentional overdose of propranolol suspension, which had been prescribed several days previously for treatment of a scalp hemangioma. Notable physical examination and laboratory findings were as follows: blood pressure, 121/84 mm Hg (normal range, 90 ± 30/60 ± 10 mm Hg); heart rate, 62 beats/min (normal range, 100-150 beats/min); respiratory rate, 24 breaths/min (normal range, 25-35 breaths/min); oxygen saturation, 100% on room air; and rectal temperature, 35...
June 15, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27218676/randomised-clinical-trial-a-phase-1-dose-ranging-study-of-the-anti-matrix-metalloproteinase-9-monoclonal-antibody-gs-5745-versus-placebo-for-ulcerative-colitis
#20
W J Sandborn, B R Bhandari, R Fogel, J Onken, E Yen, X Zhao, Z Jiang, D Ge, Y Xin, Z Ye, D French, J A Silverman, B Kanwar, G M Subramanian, J G McHutchison, S D Lee, L M Shackelton, R K Pai, B G Levesque, B G Feagan
BACKGROUND: Matrix metalloproteinase-9 is a proteolytic enzyme whose expression is increased in ulcerative colitis. AIM: To evaluate the safety and efficacy of GS-5745, a fully humanised anti-matrix metalloproteinase-9 monoclonal antibody, in moderately-to-severely active ulcerative colitis. METHODS: We randomised 74 patients with ulcerative colitis to treatment with single or multiple ascending intravenous or subcutaneous doses of GS-5745 or placebo...
July 2016: Alimentary Pharmacology & Therapeutics
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