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Amanda N Seddon, Joshua Chaim, Oguz Akin, Esther Drill, Angela G Michael, Nelly Adel, Martin S Tallman
BACKGROUND: The current standard of care for the treatment of patients with newly diagnosed acute myeloid leukemia (AML) is an anthracycline plus cytarabine. Both anthracyclines and cytarabine have been associated with the development of typhlitis, a serious adverse event characterized by inflammation of the bowel wall in patients with profound neutropenia, diagnosed by abdominal CT imaging and clinical symptoms. Given the paucity of available data, the aim of our study was to determine the incidence of typhlitis among AML patients receiving induction chemotherapy with idarubicin 12 mg/m2 (IDA), daunorubicin 60 mg/m2 (DNA60), or daunorubicin 90 mg/m2 (DNA90)...
March 8, 2018: Leukemia Research
Ahmad Nazmi Bin Ahmad Fuad, Kamal Deep, Wei Yao, Philip Rowe
This article presents the construction of a flexible drill which is designed to cut a curved canal in the bone or remove bone materials, to improve the outcome of orthopedic surgery and to facilitate minimally invasive. This article reports the design of the flexible drill and uses it in an experimental rig to evaluate the drilling force generated when cutting bovine bone. The experiments facilitate the measurement of action forces between the mill bits when moving the tip toward or across a bone sample in various configurations caused by bending the flexible drill sheath to enable cutting of a curved path of variable radius in the bone...
March 1, 2018: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
Billy T Hulin, Tim J Gabbett, Rich D Johnston, David G Jenkins
PURPOSE: Determine: 1) how change of direction (COD) workloads influence PlayerLoad variables when controlling total distance covered, and 2) relationships among collision workloads and PlayerLoad variables during rugby league match-play. METHODS: Participants completed 3 protocols (crossover design) consisting of 10 repetitions of a 60 m effort in 15 s. The difference between each protocol was the COD demands required to complete 1 repetition; no COD (SL), 1 x 180º COD (1COD), or 3 x 180º COD (3COD)...
March 15, 2018: International Journal of Sports Physiology and Performance
Alexandra Witze
No abstract text is available yet for this article.
March 15, 2018: Nature
Anna C Tasolamprou, Thomas Koschny, Maria Kafesaki, Costas M Soukoulis
We present the design of a dielectric inverse photonic crystal structure that couples line-defect waveguide propagating modes into highly directional beams of controllable directionality. The structure utilizes a triangular lattice made of air holes drilled in an infinitely thick Si slab, and it is designed for operation in the near-infrared and optical regime. The structure operation is based on the excitation and manipulation of dark dielectric surface states, in particular on the tailoring of the dark states' coupling to outgoing radiation...
November 15, 2017: ACS Photonics
Ibrahim Hussain, Theodore H Schwartz, Jeffrey P Greenfield
Basilar invagination is defined as abnormal upward and/or posterior displacement of the odontoid leading to ventral compression of the cervicomedullary junction. This condition leads to lower cranial neuropathies, sensorimotor deficits, and myelopathy. These symptoms can persist even after posterior decompression, which is an indication for ventral decompression. Transoral approaches to the upper cervical spine carry significant morbidity, limiting their utility. The endonasal approach to the upper cervical spine presents an alternative for patients with amenable anatomy...
March 13, 2018: Clinical Spine Surgery
Thierry Baussant, Marianne Nilsen, Elisa Ravagnan, Stig Westerlund, Sreerekha Ramanand
This study aimed at providing confidence in the predictability of the impacts of drill cuttings (DC) discharge on the cold-water coral Lophelia pertusa. L. pertusa was exposed to DC from offshore exploration in the lab with the goal to assess precautionary thresholds of effects. Two exposure scenarios with DC were tested: a long-term (LT) pulsed exposure (12 weeks, peak concentrations: 2-50 mg/L, mean concentrations: 1-25 mg/L) and a short-term (ST) continuous exposure (2.5 weeks, mean concentrations: 4-42 mg/L)...
March 14, 2018: Journal of Toxicology and Environmental Health. Part A
Adham M Alifarag, Christopher D Lopez, Rodrigo Neiva, Nick Tovar, Lukasz Witek, Paulo G Coelho
Osseointegration, the direct functional and structural connection between device and bone is influenced by multiple factors such as implant macrogeometry and surgical technique. This study investigated the effects of osseodensification drilling techniques on implant stability and osseointegration using trabecular metal (TM) and tapered-screw vent (TSV) implants in a low-density bone. Six skeletally mature sheep were used where six osteotomy sites were prepared in each of the ilia, (n = 2/technique: regular [R] (subtractive), clockwise [CW], and counterclockwise [CCW])...
March 14, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Jacqueline Ho, Jhih-Shyang Shih, Lucija Muehlenbachs, Clayton Munnings, Alan Krupnick
Inactive oil and gas wells present an environmental hazard if not properly plugged. Upon drilling a well, operators are required to post a bond, which ensures both that the operator has an incentive to plug and abandon (P&A) at the end of the well's life, and that, if the state is left with the liability of managing "orphaned" wells, it can cover the cost of P&A. Using data from 13 state agencies on their expenditures to plug orphan wells, we provide new estimates of P&A costs in the United States and compare P&A costs to bonds...
March 13, 2018: Environmental Science & Technology
Hao-Shan Guo, Yi-Jun Tian, Gang Liu, Long An, Zhan-Guo Zhou, Huan-Zhen Liu
OBJECTIVE: To observe the clinical effects of arthroscopy-guided core decompression and bone grafting combined with selective arterial infusion for early stage avascular necrosis of femoral head. METHODS: From January 2010 to December 2014, 76 patients(76 hips) diagnosed as Ficat II stage avascular necrosis of femoral head were randomly divided into experimental group and control group. In the experimental group, there were 27 males and 8 females aged from 24 to 55 years old with an average of (43...
January 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Lizhong Peng, Chad Meyerhoefer, Shin-Yi Chou
We investigate the health impacts of unconventional natural gas development of Marcellus shale in Pennsylvania between 2001 and 2013 by merging well permit data from the Pennsylvania Department of Environmental Protection with a database of all inpatient hospital admissions. After comparing changes in hospitalization rates over time for air pollution-sensitive diseases in counties with unconventional gas wells to changes in hospitalization rates in nonwell counties, we find a significant association between shale gas development and hospitalizations for pneumonia among the elderly, which is consistent with higher levels of air pollution resulting from unconventional natural gas development...
March 13, 2018: Health Economics
Andrea Franzini, Federico Legnani, Elena Beretta, Francesco Prada, Francesco DiMeco, Sergio Visintini, Angelo Franzini
BACKGROUND: Laminoplasty and laminectomy are two common surgical procedures utilized in approaching degenerative and neoplastic disease of the spinal canal. Routinely adopted instruments, such as Kerrison rongeur or high-speed drill (HSD), entail some potentially serious complications such as dura injuring and thermal and mechanical damage to neurovascular structures. We have adopted piezoelectric bone surgery, which permits a selective cut of mineralized tissues, to perform posterior procedures on the thoracic spine, where the relationship between bone and the spinal cord are critical...
March 9, 2018: World Neurosurgery
Zaira S Chaudhry, Steven M Raikin, Marc I Harwood, Meghan E Bishop, Michael G Ciccotti, Sommer Hammoud
BACKGROUND: Although most anterior tibial stress fractures heal with nonoperative treatment, some may require surgical management. To our knowledge, no systematic review has been conducted regarding surgical treatment strategies for the management of chronic anterior tibial stress fractures from which general conclusions can be drawn regarding optimal treatment in high-performance athletes. PURPOSE: This systematic review was conducted to evaluate the surgical outcomes of anterior tibial stress fractures in high-performance athletes...
December 1, 2017: American Journal of Sports Medicine
Darren de Sa, Ajaykumar Shanmugaraj, Melissa Weidman, Devin C Peterson, Nicole Simunovic, Volker Musahl, Olufemi R Ayeni
The all-inside technique (AIT) for anterior cruciate ligament reconstruction (ACLR) is gaining popularity as a more anatomic, less invasive, technique with the potential for more rapid recovery. This systematic review aims to critically assess components of the technique, its safety profile, outcomes, and complications. PUBMED, EMBASE, and MEDLINE were searched for studies discussing primary ACLR using the AIT. Article screening, quality assessment, and data abstraction were completed in duplicate, and a minimal clinically important difference (MCID) was used to frame the descriptive results in a clinically significant context...
February 8, 2018: Journal of Knee Surgery
Sunwook Kim, Maury A Nussbaum, Mohammad Iman Mokhlespour Esfahani, Mohammad Mehdi Alemi, Saad Alabdulkarim, Ehsan Rashedi
Use of exoskeletal vests (designed to support overhead work) can be an effective intervention approach for tasks involving arm elevation, yet little is known on the potential beneficial impacts of their use on physical demands and task performance. This laboratory study (n = 12) evaluated the effects of a prototype exoskeletal vest during simulated repetitive overhead drilling and light assembly tasks. Anticipated or expected benefits were assessed, in terms of perceived discomfort, shoulder muscle activity, and task performance...
March 7, 2018: Applied Ergonomics
Sunwook Kim, Maury A Nussbaum, Mohammad Iman Mokhlespour Esfahani, Mohammad Mehdi Alemi, Bochen Jia, Ehsan Rashedi
Adopting a new technology (exoskeletal vest designed to support overhead work) in the workplace can be challenging since the technology may pose unexpected safety and health consequences. A prototype exoskeletal vest was evaluated for potential unexpected consequences with a set of evaluation tests for: usability (especially, donning & doffing), shoulder range of motion (ROM), postural control, slip & trip risks, and spine loading during overhead work simulations. Donning/doffing the vest was easily done by a wearer alone...
March 7, 2018: Applied Ergonomics
Olivia Sonneborn, Charne Miller, Leon Head, Rachel Cross
BACKGROUND: Operating theatre services can be heavily relied upon during mass casualty disaster events, which require nurses to have adequate training and education of hospital disaster management plans to respond appropriately. The evidence-base of disaster preparedness in the acute setting is limited, particularly with regard to operating theatre nurses. OBJECTIVES: Explore operating theatre nurse's disaster knowledge of their role in a mass casualty event, and identify the preferred mode of disaster education and training to improve disaster preparedness...
February 21, 2018: Nurse Education Today
R Di Maio, S Fais, P Ligas, E Piegari, R Raga, R Cossu
As it is well-known, the characterization plan of an old landfill site is the first stage of the project for the treatment and reclamation of contaminated lands. It is a preliminary in-situ study, with collection of data related to pollution phenomena, and is aimed at defining the physical properties and the geometry of fill materials as well as the possible migration paths of pollutants to the surrounding environmental targets (subsoil and groundwater). To properly evaluate the extent and potential for subsoil contamination, waste volume and possible leachate emissions from the landfill have to be assessed...
March 7, 2018: Waste Management
Carlo Lajolo, Nicola Alberto Valente, William Giuseppe Romandini, Massimo Petruzzi, Fernando Verdugo, Antonio D'Addona
BACKGROUND: The apical portion of the implant osteotomy receives less irrigation and cooling during surgical preparation. High bone temperatures, above the critical 10°C threshold, may impair osseointegration, particularly, around dense cortical bone. The aim of this study is to evaluate the apical cortical plate temperature increase with two different devices and pressure loads in a porcine rib ex-vivo model. METHODS: Twenty-four implant sites were prepared on porcine ribs divided into 4 groups of 6 samples each according to the device used (conventional drill system or piezosurgery) and pressure load applied (1000 g or 1500 g)...
March 9, 2018: Journal of Periodontology
Michael Raessler
Arsenic is a widespread contaminant of drinking and groundwaters in the world. Even if these contaminations have a geogenic origin, they often are exacerbated by anthropogenic activities. This is particularly true for the Bengal delta. Millions of people in Bangladesh are consuming drinking water with arsenic concentrations ≥ 50 µg/L. Their drinking water supply is based on groundwaters extracted by pumping wells, which were part of a well-drilling program by the United Nations. The intention was to provide the people with groundwater instead of surface water due to its critical hygienic conditions...
March 8, 2018: Archives of Environmental Contamination and Toxicology
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