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Knowledge based treatment planning

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https://www.readbyqxmd.com/read/28453537/an-efficient-and-robust-mri-guided-radiotherapy-planning-approach-for-targeting-abdominal-organs-and-tumours-in-the-mouse
#1
Veerle Kersemans, John S Beech, Stuart Gilchrist, Paul Kinchesh, Philip D Allen, James Thompson, Ana L Gomes, Zenobia D'Costa, Luke Bird, Iain D C Tullis, Robert G Newman, Aurelien Corroyer-Dulmont, Nadia Falzone, Abul Azad, Katherine A Vallis, Owen J Sansom, Ruth J Muschel, Borivoj Vojnovic, Mark A Hill, Emmanouil Fokas, Sean C Smart
INTRODUCTION: Preclinical CT-guided radiotherapy platforms are increasingly used but the CT images are characterized by poor soft tissue contrast. The aim of this study was to develop a robust and accurate method of MRI-guided radiotherapy (MR-IGRT) delivery to abdominal targets in the mouse. METHODS: A multimodality cradle was developed for providing subject immobilisation and its performance was evaluated. Whilst CT was still used for dose calculations, target identification was based on MRI...
2017: PloS One
https://www.readbyqxmd.com/read/28447959/using-measurable-dosimetric-quantities-to-characterize-the-inter-structural-tradeoff-in-inverse-planning
#2
Hongcheng Liu, Peng Dong, Lei Xing
Traditional inverse planning relies on the use of weighting factors to balance the conflicting requirements of different structures. The manual trial-and-error determination of the weighting factors has long been recognized as a time-consuming part of treatment planning. The purpose of this work is to develop an inverse planning framework that parameterizes the dosimetric tradeoff among the structures with physically meaningful quantities to simplify the search for clinically sensible plans. In this formalism, instead of using the weighting factors, permissible variation range of the prescription dose or dose volume histogram (DVH) of the involved structures are used to characterize the "importance" of the structures...
April 27, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28442282/attitude-and-intention-regarding-pain-management-among-chinese-nursing-students-a-cross-sectional-questionnaire-survey
#3
Liang-Yu Fang, Yin-Chuan Xu, Dan-Ni Lin, Jing-Feng Jin, Min Yan
Optimal pain management is a priority in effective nursing care. Lack of sufficient pain knowledge associated with inadequate pain management has been proved. However, the intention, defined as the predictor of behavior, regarding pain management remains unknown. Therefore, the study was to determine the attitude and intention regarding pain management among Chinese nursing students and investigate the underlying determinants and their interactions in terms of intention toward pain management. The Pain Management Survey Questionnaire, comprising the key determinants of the theory of planned behavior-that is, direct attitude, belief-based intention, subjective norm, direct control, and indirect control-was used to collect data from 512 nursing students who undertook clinical rotation in an affiliated hospital of a medical college in China...
April 23, 2017: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://www.readbyqxmd.com/read/28442156/treatment-decision-making-in-ductal-carcinoma-in-situ-a-mixed-methods-systematic-review-of-women-s-experiences-and-information-needs
#4
REVIEW
Claudia Rutherford, Rebecca Mercieca-Bebber, Phyllis Butow, Jenny Liang Wu, Madeleine T King
OBJECTIVE: Decision-making in ductal carcinoma in situ (DCIS) is complex due to the heterogeneity of the disease. This study aimed to understand women's experience of making treatment decisions for DCIS, their information and support needs, and factors that influenced decisions. METHODS: We searched six electronic databases, conference proceedings, and key authors. Two reviewers independently applied inclusion and quality criteria, and extracted findings. Thematic analysis was used to combine and summarise findings...
April 15, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28438215/predicting-liver-sbrt-eligibility-and-plan-quality-for-vmat-and-4%C3%AF-plans
#5
Angelia Tran, Kaley Woods, Dan Nguyen, Victoria Y Yu, Tianye Niu, Minsong Cao, Percy Lee, Ke Sheng
BACKGROUND: It is useful to predict planned dosimetry and determine the eligibility of a liver cancer patient for SBRT treatment using knowledge based planning (KBP). We compare the predictive accuracy using the overlap volume histogram (OVH) and statistical voxel dose learning (SVDL) KBP prediction models for coplanar VMAT to non-coplanar 4π radiotherapy plans. METHODS: In this study, 21 liver SBRT cases were selected, which were initially treated using coplanar VMAT plans...
April 24, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28433682/a-mechanistic-review-on-vermifiltration-of-wastewater-design-operation-and-performance
#6
REVIEW
Rajneesh Singh, Puspendu Bhunia, Rajesh R Dash
With global population explosion, the available water resources are slowly being polluted due to the excessive human interference. To encounter this, it is the need of this hour to find out sustainable pollution remediating technologies to meet the stringent discharge standards for domestic as well as industrial wastewaters. In addition, those techniques should have the capabilities for effective implementation even in developing countries. Based on the available literatures, one such technique, named vermifilter, has been identified which takes care of almost all the sustainable and economical criteria for its effective implementation even in developing countries...
April 19, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28429239/development-and-initial-validation-of-a-short-three-dimensional-inventory-of-character-strengths
#7
Wenjie Duan, He Bu
PURPOSE: Character strength is described as a positive and organized pattern of emotions, thoughts, and behaviors. It serves as a schema that organizes categories of information toward the self, others, and the world, and provides the self-aware knowledge that facilitates the pursuit of goals, values, and ethical principles. Recent research has suggested that three reliable factors emerge from the measures of character strengths: caring, inquisitiveness, and self-control. The goal of this paper is to develop a psychometrically sound short measure of character strength...
April 20, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28425324/persistent-idiopathic-facial-pain
#8
Rafael Benoliel, Charly Gaul
Background Persistent idiopathic facial pain (PIFP) is a chronic disorder recurring daily for more than two hours per day over more than three months, in the absence of clinical neurological deficit. PIFP is the current terminology for Atypical Facial Pain and is characterized by daily or near daily pain that is initially confined but may subsequently spread. Pain cannot be attributed to any pathological process, although traumatic neuropathic mechanisms are suspected. When present intraorally, PIFP has been termed 'Atypical Odontalgia', and this entity is discussed in a separate article in this special issue...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28420604/a-digital-tool-to-promote-alcohol-and-drug-use-screening-brief-intervention-and-referral-to-treatment-skill-translation-a-mobile-app-development-and-randomized-controlled-trial-protocol
#9
Derek D Satre, Khanh Ly, Maria Wamsley, Alexa Curtis, Jason Satterfield
BACKGROUND: Translation of knowledge and skills from classroom settings to clinical practice is a major challenge in healthcare training, especially for behavioral interventions. For example, screening, brief intervention, and referral to treatment (SBIRT) is a highly-promoted approach to identifying and treating individuals at risk for alcohol or drug problems, yet effective, routine use of SBIRT has lagged. OBJECTIVE: The objective of this paper is to describe the development, pilot testing, and trial protocol of a mobile app based on the theory of planned behavior (TPB) to promote SBIRT skill translation and application...
April 18, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28419714/young-people-s-beliefs-about-the-risk-of-bowel-cancer-and-its-link-with-physical-activity
#10
Katie V Newby, Chloe Cook, Susanne F Meisel, Thomas L Webb, Bernadette Fisher, Abi Fisher
OBJECTIVES: The primary objective was to explore young people's risk appraisals of bowel cancer, including whether they had a coherent understanding of the protective effects of physical activity (PA). A secondary objective was to examine whether the illness risk representations (IRRs) framework could be used to understand beliefs underlying bowel cancer risk appraisals. DESIGN: Qualitative. METHODS: Framework analysis of semi-structured interviews with 19 people aged 14-17 years...
April 17, 2017: British Journal of Health Psychology
https://www.readbyqxmd.com/read/28416280/progress-toward-gene-therapy-for-duchenne-muscular-dystrophy
#11
REVIEW
Joel R Chamberlain, Jeffrey S Chamberlain
Duchenne muscular dystrophy (DMD) has been a major target for gene therapy development for nearly 30 years. DMD is among the most common genetic diseases, and isolation of the defective gene (DMD, or dystrophin) was a landmark discovery, as it was the first time a human disease gene had been cloned without knowledge of the protein product. Despite tremendous obstacles, including the enormous size of the gene and the large volume of muscle tissue in the human body, efforts to devise a treatment based on gene replacement have advanced steadily through the combined efforts of dozens of labs and patient advocacy groups...
April 14, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28415881/hip-and-pelvic-fracture-patients-with-fear-of-falling-development-and-description-of-the-step-by-step-treatment-protocol
#12
Karin Kampe, Michaela Kohler, Diana Albrecht, Clemens Becker, Martin Hautzinger, Ulrich Lindemann, Klaus Pfeiffer
OBJECTIVE: Based on a theoretical framework and sound evidence, this article describes a rehabilitation programme for patients with fear of falling after hip and pelvic fracture. RATIONALE: Based on exercise science principles, current knowledge from fall prevention, emotion regulation, and the Health Action Process Approach we developed a theoretical framework, from which the components of the intervention were derived. Description of the intervention: The intervention consists of 6 components: (1) relaxation, (2) meaningful activities and mobility-based goals, (3) falls related cognitions and emotions, coping with high risk tasks and situations, (4) individual exercise programme, (5) planning and implementing exercises and activities, and (6) fall risks and hazards...
May 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28411963/using-a-knowledge-based-planning-solution-to-select-patients-for-proton-therapy
#13
Alexander R Delaney, Max Dahele, Jim P Tol, Ingrid T Kuijper, Ben J Slotman, Wilko F A R Verbakel
BACKGROUND AND PURPOSE: Patient selection for proton therapy by comparing proton/photon treatment plans is time-consuming and prone to bias. RapidPlan™, a knowledge-based-planning solution, uses plan-libraries to model and predict organ-at-risk (OAR) dose-volume-histograms (DVHs). We investigated whether RapidPlan, utilizing an algorithm based only on photon beam characteristics, could generate proton DVH-predictions and whether these could correctly identify patients for proton therapy...
April 12, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28410684/knowledge-based-treatment-planning-an-inter-technique-and-inter-system-feasibility-study-for-prostate-cancer
#14
Elisabetta Cagni, Andrea Botti, Renato Micera, Maria Galeandro, Roberto Sghedoni, Matteo Orlandi, Cinzia Iotti, Luca Cozzi, Mauro Iori
PURPOSE: Helical Tomotherapy (HT) plans were used to create two RapidPlan knowledge-based (KB) models to generate plans with different techniques and to guide the optimization in a different treatment planning system for prostate plans. Feasibility and performance of these models were evaluated. MATERIAL AND METHODS: two sets of 35 low risk (LR) and 30 intermediate risk (IR) prostate cancer cases who underwent HT treatments were selected to train RapidPlan models...
April 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28410187/comparing-web-based-provider-initiated-and-patient-initiated-survivorship-care-planning-for-cancer-patients-a-randomized-controlled-trial
#15
Katherine Clegg Smith, Elliott Tolbert, Susan M Hannum, Archana Radhakrishnan, Kelsey Zorn, Amanda Blackford, Stephen Greco, Karen Smith, Claire F Snyder
BACKGROUND: Survivorship care plans (SCPs) are intended to facilitate communication and coordination between patients, oncologists, and primary care providers. Most SCP initiatives have focused on oncology providers initiating the SCP process, but time and resource barriers have limited uptake. OBJECTIVE: This trial compares the feasibility and value of 2 Web-based SCP tools: provider-initiated versus patient-initiated. METHODS: This mixed-methods study recruited clinicians from 2 academically-affiliated community oncology practices...
August 30, 2016: JMIR Cancer
https://www.readbyqxmd.com/read/28399952/reducing-the-treatment-gap-for-mental-neurological-and-substance-use-disorders-in-africa-lessons-from-the-friendship-bench-in-zimbabwe
#16
D Chibanda
Mental, neurological and substance use disorders (MNS) are a leading cause of disability in Africa. In response to the large treatment gap for MNS, a growing body of evidence-based treatments (EBTs) is emerging from Africa; however, there is a dearth of knowledge on how to scale up EBT. The Friendship Bench intervention is a brief psychological treatment delivered through the primary health care system in Zimbabwe by trained lay health workers. It has contributed significantly towards narrowing the treatment gap for common mental disorders in Zimbabwe where it has been scaled up to over 70 primary health care facilities...
April 12, 2017: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/28399909/myplan-mobile-phone-application-to-manage-crisis-of-persons-at-risk-of-suicide-study-protocol-for-a-randomized-controlled-trial
#17
Kate Andreasson, Jesper Krogh, Per Bech, Hanne Frandsen, Niels Buus, Barbara Stanley, Ad Kerkhof, Merete Nordentoft, Annette Erlangsen
BACKGROUND: Persons with a past episode of self-harm or severe suicidal ideation are at elevated risk of self-harm as well as dying by suicide. It is well established that suicidal ideation fluctuates over time. Previous studies have shown that a personal safety plan can assist in providing support, when a person experiences suicide ideation, and help seeking professional assistance if needed. The aim of the trial is to determine whether a newly developed safety mobile app is more effective in reducing suicide ideation and other symptoms, compared to a safety plan on paper...
April 11, 2017: Trials
https://www.readbyqxmd.com/read/28384178/prevalence-of-multimorbidity-in-the-brazilian-adult-population-according-to-socioeconomic-and-demographic-characteristics
#18
Januse Nogueira de Carvalho, Ângelo Giuseppe Roncalli, Marianna de Camargo Cancela, Dyego Leandro Bezerra de Souza
Knowledge on the occurrence of multimorbidity is important from the viewpoint of public policies, as this condition increases the consumption of medicines as well as the utilization and expenses of health services, affecting life quality of the population. The objective of this study was to estimate prevalence of self-reported multimorbidity in Brazilian adults (≥18 years old) according to socioeconomic and demographic characteristics. A descriptive study is presented herein, based on data from the National Health Survey, which was a household-based survey carried out in Brazil in 2013...
2017: PloS One
https://www.readbyqxmd.com/read/28344419/determinants-of-treatment-modification-in-hypercholesterolemic-patients
#19
Ko-Fan Wang, Cheng-Hsueh Wu, Chun-Chin Chang, Lung-Ching Chen, Kang-Ling Wang, Tse-Min Lu, Shing-Jong Lin, Chern-En Chiang
BACKGROUND: There is a lack of knowledge of those contemporary factors associated with modifying subtherapeutic treatments in hypercholesterolemic patients. The aim of this study was to assess determinants of treatment modification in patients not attaining their low-density lipoprotein cholesterol goals. METHODS: The CEntralized Pan-Asian survey on tHE Under-treatment of hypercholeSterolemia enrolled patients taking stable lipid-lowering medications. The study physicians then determined existing patient treatments, which were to be continued or modified when treatments failed...
March 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/28337766/integration-of-family-planning-services-into-hiv-care-and-treatment-services-a-systematic-review
#20
Sabina A Haberlen, Manjulaa Narasimhan, Laura K Beres, Caitlin E Kennedy
Evidence on the feasibility, effectiveness, and cost-effectiveness of integrating family planning (FP) and HIV services has grown significantly since the 2004 Glion Call to Action. This systematic review adds to the knowledge base by characterizing the range of models used to integrate FP into HIV care and treatment, and synthesizing the evidence on integration outcomes among women living with HIV. Fourteen studies met our inclusion criteria, eight of which were published after the last systematic review on the topic in 2013...
March 24, 2017: Studies in Family Planning
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