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Knowledge based treatment planning

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https://www.readbyqxmd.com/read/28898740/transition-from-children-s-to-adult-services-for-young-adults-with-life-limiting-conditions-a-realist-review-of-the-literature
#1
REVIEW
Helen Kerr, Jayne Price, Honor Nicholl, Peter O'Halloran
BACKGROUND: Improvements in care and treatment have led to more young adults with life-limiting conditions living beyond childhood, which means they must make the transition from children's to adult services. This has proved a challenging process for both young adults and service providers, with complex transition interventions interacting in unpredictable ways with local contexts. OBJECTIVES: To explain how intervention processes interact with contextual factors to help transition from children's to adult services for young adults with life-limiting conditions...
June 23, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28895960/atopic-dermatitis-therapeutic-care-delivery-therapeutic-education-shared-decision-making-and-access-to-care
#2
Jennifer LeBovidge, Jenna Borok, Jeremy Udkoff, Gil Yosipovitch, Lawrence F Eichenfield
Atopic dermatitis (AD) is a chronic skin condition affecting children and adults, with a significant negative impact on patient and caregiver quality of life (QOL). Although effective treatments for AD are available, outcomes are often limited by poor adherence to treatment plans. Effective patient and caregiver education about the disease and its management is a necessary and important component of AD care. Therapeutic patient education (TPE) is a patient-centered process that aims to transfer information and skills necessary to manage and cope with a disease from health care professionals to patients and caregivers...
September 2017: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28893672/a-situational-analysis-of-current-antimicrobial-governance-regulation-and-utilisation-in-south-africa
#3
Natalie Schellack, Deon Benjamin, Adrian Brink, Adriano Duse, Kim Faure, Debra Goff, Marc Mendelson, Johanna Meyer, Jacqui Miot, Olga Perovic, Troy Pople, Fatima Suleman, Moritza van Vuuren, Sabiha Essack
The Global Action Plan (GAP) on AMR calls for optimising the use of antimicrobial medicines in human and animal health, in tandem with strengthening of the knowledge and evidence base through surveillance and research. However, there is a paucity of consumption data in African countries such as South Africa. Determining antimicrobial consumption data in low resource settings remains a challenge. This paper describes alternative mechanisms of assessing antimicrobial consumption data such as Intercontinental Marketing Services (IMS), and contract data arising from tenders (an open Request for Proposal, RFP) as opposed to the international norms of daily defined doses per 100 patient days, or per 1000 of the population...
September 8, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28881381/muscle-mass-at-the-time-of-diagnosis-of-nonmetastatic-colon-cancer-and-early-discontinuation-of-chemotherapy-delays-and-dose-reductions-on-adjuvant-folfox-the-c-scans-study
#4
Elizabeth M Cespedes Feliciano, Valerie S Lee, Carla M Prado, Jeffrey A Meyerhardt, Stacey Alexeeff, Candyce H Kroenke, Jingjie Xiao, Adrienne L Castillo, Bette J Caan
BACKGROUND: For many chemotherapy regimens dosed based on body surface area (BSA), patients experience dose reductions or delays or discontinue treatment, thereby reducing survival. Consideration of body composition may be useful in individualizing chemotherapy dosing, but to the authors' knowledge few studies to date have examined the association of body composition with chemotherapy tolerance in patients with colon cancer. METHODS: The authors identified patients with nonmetastatic colon cancer who were diagnosed from 2006 through 2011 at Kaiser Permanente and who received leucovorin calcium/calcium folinate, 5-fluorouracil, and oxaliplatin (FOLFOX) as initial adjuvant chemotherapy (533 patients)...
September 7, 2017: Cancer
https://www.readbyqxmd.com/read/28871982/evaluating-the-toxicity-reduction-with-computed-tomographic-ventilation-functional-avoidance-radiation-therapy
#5
Austin M Faught, Yuya Miyasaka, Noriyuki Kadoya, Richard Castillo, Edward Castillo, Yevgeniy Vinogradskiy, Tokihiro Yamamoto
PURPOSE: Computed tomographic (CT) ventilation imaging is a new modality that uses 4-dimensional (4D) CT information to calculate lung ventilation. Although retrospective studies have reported on the reduction in dose to functional lung, no work to our knowledge has been published in which the dosimetric improvements have been translated to a reduction in the probability of pulmonary toxicity. Our work estimates the reduction in toxicity for CT ventilation-based functional avoidance planning...
October 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28870791/performance-of-knowledge-based-radiation-therapy-planning-for-the-glioblastoma-disease-site
#6
Avishek Chatterjee, Monica Serban, Bassam Abdulkarim, Valerie Panet-Raymond, Luis Souhami, George Shenouda, Siham Sabri, Bertrand Jean-Claude, Jan Seuntjens
PURPOSE: The presence of multiple serial organs at risk (OARs) in close proximity to the tumor makes treatment planning for glioblastoma (GBM) complex and time consuming. The present study aimed to create a knowledge-based (KB) radiation therapy model for GBM patients using RapidPlan. METHODS AND MATERIALS: An initial model was trained using 82 glioblastoma patients treated with 60 Gy in 30 fractions. Plans were created using either volumetric modulated arc therapy (VMAT) or intensity modulated radiation therapy (IMRT)...
July 14, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28870279/graph-based-impact-analysis-as-a-framework-for-incorporating-practitioner-knowledge-in-dairy-herd-health-management
#7
M Krieger, E-M Schwabenbauer, S Hoischen-Taubner, U Emanuelson, A Sundrum
Production diseases in dairy cows are multifactorial, which means they emerge from complex interactions between many different farm variables. Variables with a large impact on production diseases can be identified for groups of farms using statistical models, but these methods cannot be used to identify highly influential variables in individual farms. This, however, is necessary for herd health planning, because farm conditions and associated health problems vary largely between farms. The aim of this study was to rank variables according to their anticipated effect on production diseases on the farm level by applying a graph-based impact analysis on 192 European organic dairy farms...
September 5, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28870236/acquired-hemophilia-a-in-an-advanced-age-patient-of-hispanic-origin-a-case-report
#8
Nalyssa I Rivera Cora, Freddie Irizarry Delgado, Santa M Merle Ramírez, Jorge Vera Quiñones
BACKGROUND: Acquired Hemophilia A (AHA) is a rare hematological disorder that exhibits an incidence of approximately 1.5 cases per million patients a year. It is characterized by the development of autoantibodies against circulating Factor VIII coagulation proteins which, in turn, which in turn lead to potentially life-threatening hemorrhagic episodes. The incidence of AHA increases with age; with 80% of the affected patient population encompassing men and women that are 65 years or older...
September 4, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28869401/clinical-outcomes-of-multileaf-collimator-based-cyberknife-for-spine-stereotactic-body-radiation-therapy
#9
Nalee Kim, Ho Lee, Jin Sung Kim, Jong Geal Baek, Chang Geol Lee, Sei Kyung Chang, Woong Sub Koom
OBJECTIVE: Stereotactic body radiotherapy (SBRT) for spinal metastases is becoming a prevalent therapeutic option. We aimed to evaluate the clinical feasibility and outcomes of the recently developed multileaf collimator (MLC)-based CyberKnife (CK-M) for spine SBRT. METHODS: We reviewed 119 patients of 144 cases with 229 lesions treated with CK between November 2014 and March 2016. The lesion features, dosimetric parameters, and clinical outcomes were compared between fixed cone collimator based CK (CK-F) and CK-M...
September 4, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28869212/increased-mental-health-treatment-financing-community-based-organization-s-treatment-programs-and-latino-white-children-s-financing-disparities
#10
Lonnie R Snowden, Neal Wallace, Kate Cordell, Genevieve Graaf
BACKGROUND: Latino child populations are large and growing, and they present considerable unmet need for mental health treatment. Poverty, lack of health insurance, limited English proficiency, stigma, undocumented status, and inhospitable programming are among many factors that contribute to Latino-White mental health treatment disparities. Lower treatment expenditures serve as an important marker of Latino children's low rates of mental health treatment and limited participation once enrolled in services...
September 1, 2017: Journal of Mental Health Policy and Economics
https://www.readbyqxmd.com/read/28864427/social-media-for-the-dissemination-of-cochrane-child-health-evidence-evaluation-study
#11
Michele P Dyson, Amanda S Newton, Kassi Shave, Robin M Featherstone, Denise Thomson, Aireen Wingert, Ricardo M Fernandes, Lisa Hartling
BACKGROUND: Health care providers value ready access to reliable synthesized information to support point-of-care decision making. Web-based communities, facilitated by the adoption of social media tools such as Facebook, Twitter, and YouTube, are increasingly being used for knowledge dissemination, bridging the gap between knowledge generation and synthesis and knowledge implementation. OBJECTIVE: Our objective was to implement and evaluate a structured social media strategy, using multiple platforms, to disseminate Cochrane Child Health evidence to health care providers caring for children...
September 1, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28860859/head-and-neck-cancer-improving-outcomes-with-a-multidisciplinary-approach
#12
REVIEW
Cristiana Lo Nigro, Nerina Denaro, Anna Merlotti, Marco Merlano
For early-stage head and neck cancer (HNC), surgery (S) or radiotherapy (RT) is a standard treatment. The multidisciplinary approach, which includes multimodality treatment with S followed by RT, with or without chemotherapy (CT) or concurrent chemoradiotherapy (CRT), is required for locally advanced head and neck cancer (LAHNC). CRT improves prognosis, locoregional control (LRC), and organ function in LAHNC, compared to RT alone. Prognosis in recurrent/metastatic HNC (R/M HNC) is dismal. Platinum-based CT, combined with the anti-Epidermal Growth Factor Receptor (EGFR) antibody (Ab) cetuximab, is used in first-line setting, while no further validated options are available at progression...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/28857446/diagnostic-accuracy-of-pre-treatment-biopsy-for-grading-cutaneous-mast-cell-tumours-in-dogs
#13
T Shaw, S T Kudnig, S M Firestone
Mast cell tumours (MCTs) are common tumours of the canine skin, and are estimated to represent up to 20% of all skin tumours in dogs. Tumour grade has a major impact on the incidence of local recurrence and metastatic potential. In addition to helping the clinician with surgical planning, knowledge of the tumour grade also assists in proper prognostication and client education. For pre-treatment biopsies to be useful, there must exist a high level of correlation between the histopathological grade obtained from the pre-treatment biopsy and the actual histopathological grade from the excisional biopsy...
August 31, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28838022/-characteristics-and-treatment-strategies-for-penetrating-injuries-on-the-example-of-gunshot-and-blast-victims-without-ballistic-body-armour-in-afghanistan-2009%C3%A2-%C3%A2-2013
#14
Christoph Güsgen, Arnulf Willms, Ines Richardsen, Dan Bieler, Erwin Kollig, Robert Schwab
Much like other countries, Germany has recently seen terrorist attacks being planned, executed or prevented at the last minute. This highlights the need for expertise in the treatment of penetrating torso traumas by bullets or explosions. Data on the treatment of firearm injuries and, even more so, blast injuries often stems from crises or war regions. However, it is difficult to compare injuries from such regions with injuries from civilian terrorist attacks due to the ballistic body protection (protective vests, body armour) worn by soldiers...
August 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/28834585/a-combined-learning-algorithm-for-prostate-segmentation-on-3d-ct-images
#15
Ling Ma, Rongrong Guo, Guoyi Zhang, David S Schuster, Baowei Fei
PURPOSE: Segmentation of the prostate on CT images has many applications in the diagnosis and treatment of prostate cancer. Because of the low soft-tissue contrast on CT images, prostate segmentation is a challenging task. A learning-based segmentation method is proposed for the prostate on three-dimensional (3D) CT images. METHODS: We combine population-based and patient-based learning methods for segmenting the prostate on CT images. Population data can provide useful information to guide the segmentation processing...
August 23, 2017: Medical Physics
https://www.readbyqxmd.com/read/28831460/disease-staging-index-for-aggressive-periodontitis
#16
Srinivas Sulugodu Ramachandra, José Dopico, Nikos Donos, Luigi Nibali
Major advances in the knowledge about the aetiopathogenesis of aggressive periodontitis (AgP) have been achieved. An ever increasing number of scientific articles related to AgP are published every year contributing significantly to the knowledge of this unique and complex disease. AgP has been classified into localised and generalised forms based on their extent and disease progression with distinct clinical and radiological features. A classification of AgP based on severity (mild, moderate and severe) exists; however, it is not easily applicable...
2017: Oral Health & Preventive Dentistry
https://www.readbyqxmd.com/read/28830372/tuberculosis-active-case-finding-in-cambodia-a-pragmatic-cost-effectiveness-comparison-of-three-implementation-models
#17
Richard James, Keovathanak Khim, Lydia Boudarene, Joanne Yoong, Chea Phalla, Saly Saint, Pichenda Koeut, Tan Eang Mao, Richard Coker, Mishal Sameer Khan
BACKGROUND: Globally, almost 40% of tuberculosis (TB) patients remain undiagnosed, and those that are diagnosed often experience prolonged delays before initiating correct treatment, leading to ongoing transmission. While there is a push for active case finding (ACF) to improve early detection and treatment of TB, there is extremely limited evidence about the relative cost-effectiveness of different ACF implementation models. Cambodia presents a unique opportunity for addressing this gap in evidence as ACF has been implemented using different models, but no comparisons have been conducted...
August 22, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28830219/optimisation-of-radiotherapy-fractionation-schedules-based-on-radiobiological-functions
#18
Fernando Pizarro, Araceli Hernández
OBJECTIVE: To present a method for optimising radiotherapy fractionation schedules using radiobiological tools and taking into account the patient's dose-volume histograms (DVH). METHODS: This method uses a figure of merit based on the uncomplicated tumour control probability (P+) and the generalised equivalent uniform dose (gEUD). A set of doses per fraction is selected in order to find the dose per fraction and the total dose, thus maximising the figure of merit and leading to a biologically effective dose that is similar to the prescribed schedule...
August 22, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28830203/multimodal-image-registration-for-the-identification-of-dominant-intraprostatic-lesion-in-high-precision-radiotherapy-treatments
#19
Delia Ciardo, Barbara Alicja Jereczek-Fossa, Giuseppe Petralia, Giorgia Timon, Dario Zerini, Raffaella Cambria, Elena Rondi, Federica Cattani, Alessia Bazani, Rosalinda Ricotti, Maria Garioni, Davide Maestri, Giulia Marvaso, Paola Romanelli, Marco Riboldi, Guido Baroni, Roberto Orecchia
PURPOSE: The integration of computed tomography (CT) and multiparametric magnetic resonance imaging (mpMRI) is a challenging task in high-precision radiotherapy for prostate cancer. A simple methodology for multimodal deformable image registration (DIR) of prostate cancer patients is presented. METHODS: CT and mpMRI of ten patients were considered. Organs at risk and prostate were contoured on both scans. The dominant intraprostatic lesion was additionally delineated on magnetic resonance imaging...
August 22, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28812121/-teaching-in-orthopaedic-and-trauma-surgery
#20
T Renkawitz, A Benditz, M Rüsseler, U Obertacke, J Grifka, M Weber
The scramble for available places to study medicine in Germany continues. One of the core points within the "Master Plan 2020", which has been recently adopted, is the reform of teaching concepts at German medical faculties. In the future, students of human medicine are to be trained primarily based upon competence-oriented, integrated curricula. The present paper is intended to present modern teaching concepts and methods, as well as current examination formats, which play a special role in student training in orthopaedics and traumatology...
August 15, 2017: Der Orthopäde
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