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Xia Yang, Xin Ye, Licheng Zhang, Dianzhong Geng, Zhenli Du, Guohua Yu, Haipeng Ren, Jiao Wang, Guanghui Huang, Zhigang Wei, Yang Ni, Wenhong Li, Xiaoying Han
BACKGROUND: The study was conducted to retrospectively evaluate the safety and effectiveness of computed tomography (CT)-guided percutaneous microwave ablation (MWA) for peripheral non-small cell lung cancer (NSCLC) in 11 patients with a single lung after pneumonectomy. METHODS: From May 2011 to March 2015, 11 single-lung patients (8 men and 3 women; mean age 60.3 years, range 46-71) with peripheral NSCLC underwent 12 sessions of MWA. Eleven tumors measuring 13-52 mm (mean 30...
March 12, 2018: Thoracic Cancer
Abdulhadi A AlAmodi, Mohamad H Farhoud, Najwa Mohammad, Rawan Alatassi, Dana Alolayet, Noor AlQeshtaini, Raghad AlMamlouk, Mohamed Hussein Ahmed, Mahmoud Ashour, Sara S Kayyali, Abdullah AlShammari
BACKGROUND Leiomyomas are benign neoplasms of the smooth muscle. When found in the pulmonary system, a rare occurrence, leiomyomas can result in hypertrophic osteoarthropathy, or significant clubbing, associated with proliferation of long bone periosteum. Bronchopulmonary fistulas, or communications between the bronchial tree and pleural space, are an uncommon postoperative complication of pneumonectomies. Even more infrequent is the presence of a bronchopulmonary fistula that is determined to be sterile. CASE REPORT The patient presented in the current case report is a 40-year-old previously healthy woman who presented with a 5-year history of chronic cough, right-sided chest discomfort, and dyspnea associated with back pain, and lower leg pain...
March 9, 2018: American Journal of Case Reports
Soner Gursoy, Serkan Yazgan, Ahmet Ucvet, Ozgur Samancilar, Mehmet Unal, Baris Gulmez, Esra Yamansavci Sirzai
PURPOSE: Bronchopleural fistula (BPF) is a catastrophic complication after pneumonectomy, still associated with high mortality. We reviewed our recent experience of managing BPF, particularly after right pneumonectomy for non-small cell lung cancer (NSCLC), and analyzed our findings. METHODS: A total of 436 patients underwent pneumonectomy for NSCLC in our department between January 2000 and June 2017. BPF developed during follow-up in 47 of these patients, who are the subjects of this retrospective analysis...
March 7, 2018: Surgery Today
Hasan Fevzi Batirel, Muzaffer Metintas, Hale Basak Caglar, Guntulu Ak, Perran Fulden Yumuk, Rengin Ahiskali, Emine Bozkurtlar, Nural Bekiroglu, Tunc Lacin, Bedrettin Yildizeli, Mustafa Yuksel
OBJECTIVE: Macroscopic complete resection (MCR) is the recommended surgical strategy in malignant pleural mesothelioma. Our objective was to analyze whether MCR influences survival in malignant pleural mesothelioma. METHODS: Between 2002 and 2016, 154 patients underwent pleurectomy decortication (n = 90), extrapleural pneumonectomy (n = 42), or exploratory/diagnostic procedures (n = 22) in a single institution. Patient data were recorded in a prospective database...
February 9, 2018: Journal of Thoracic and Cardiovascular Surgery
Pier Luigi Filosso, Francesco Guerrera, Paolo Olivo Lausi, Roberto Giobbe, Paraskevas Lyberis, Enrico Ruffini, Alberto Oliaro
No abstract text is available yet for this article.
January 2018: Journal of Thoracic Disease
Piergiorgio Solli, Jury Brandolini, Alessandro Pardolesi, Marco Nardini, Nicola Lacava, Sergio Forti Parri, Kenji Kawamukai, Barbara Bonfanti, Luca Bertolaccini
Extrapleural pneumonectomy (EPP) and pleurectomy-decortication (P/D) are both recognised surgical procedures for selected cases affected by malignant pleural mesothelioma (MPM). Surgical techniques have ameliorated over the last years, remaining the complete macroscopic resection of the disease the main surgical principle. EPP is defined as an en-bloc resection of the visceral pleura, parietal pleura, pericardium and diaphragm alongside the pneumonectomy. The thoracic domain of the International Association for Study of Lung Cancer (IASLC) recently clarified the, previously confused, surgical terminology...
January 2018: Journal of Thoracic Disease
Sara Ricciardi, Giuseppe Cardillo, Carmelina Cristina Zirafa, Francesco Carleo, Francesco Facciolo, Gabriella Fontanini, Luciano Mutti, Franca Melfi
Currently there is no universally accepted surgical therapy for malignant pleural mesothelioma (MPM). The goal of surgery in this dismal disease is a macroscopic complete resection (MCR) and there are two types of intervention with a curative intent. At one side, there is the extrapleural pneumonectomy (EPP) which consists in an en-bloc resection of the lung, pleura, pericardium and diaphragm and at the other side, there is pleurectomy/decortication (P/D) a lung-sparing surgery. Initially, EPP was considered the only surgical option with a curative aim, but during the decades P/D have acquired a role of increasing importance in MPM therapy...
January 2018: Journal of Thoracic Disease
Luca Ampollini, Elisabetta Barocelli, Andrea Cavazzoni, Piergiorgio Petronini, Claudio Mucchino, Anna Maria Cantoni, Fabio Leonardi, Luigi Ventura, Stefano Barbieri, Paolo Colombo, Antonella Fusari, Paolo Carbognani, Michele Rusca, Fabio Sonvico
Background: Malignant pleural mesothelioma (MPM) continues to be a distressing tumor due to its aggressive biologic behavior and scanty prognosis. Several therapeutic approaches have been tested both in clinical and preclinical settings, being intrapleural chemotherapy one of the most promising. Some years ago, our interest focused on polymeric films loaded with cisplatin for the adjuvant intrapleural treatment of surgical patients. After in vitro and in vivo studies in a rat recurrence model of MPM, the aim of this study was to evaluate the pharmacokinetics of the polymeric films in a sheep model in view of further studies in a clinical setting...
January 2018: Journal of Thoracic Disease
Haruhiko Shiiya, Yasuhiro Hida, Kichizo Kaga, Rei Inoue, Reiko Nakada-Kubota, Yoshiro Matsui
Complete surgical resection has been considered the only curable treatment for thymoma. The efficacy of extrapleural pneumonectomy (EPP) for stage IV thymomas remains controversial. In this case report, we utilize EPP for recurrent thymoma with pleural dissemination and describe the resulting outcome. A 39-year-old female with a history of thoracoscopic thymectomy for type B2 thymoma was referred to our hospital for a recurrence of thymoma with pleural dissemination. She underwent EPP as a radical surgery. Histopathological investigation revealed complete resection...
May 2018: Respirology Case Reports
Brittany N Burton, Swapnil Khoche, Alison M A'Court, Ulrich H Schmidt, Rodney A Gabriel
OBJECTIVE: Postoperative respiratory failure requiring reintubation is associated with a significant increase in mortality. However, perioperative risk factors and their effects on unplanned 30-day reintubation and postoperative outcomes after unplanned reintubation following lung resection are not described well. The aim of this study was to determine whether certain comorbidities, demographic factors, and postoperative outcomes are associated with 30-day reintubation after thoracic surgery...
January 31, 2018: Journal of Cardiothoracic and Vascular Anesthesia
Tibor Géczi, Edit Csada, László Tiszlavicz, György Lázár, József Furák
INTRODUCTION: Lung cancer is the most common malignant tumor in Europe and Hungary. In 2010, 10 557 new cases were registered in Hungary; 80-85% of these cases were associated with smoking. AIM: In our work we analyzed the data of lung cancer patients of the last 15 years retrospectively. METHOD: We examined the demographic characteristics, the histological type, the stage of the lung cancer, the type of the surgical procedure used, other supplemental treatment and survival retrospectively...
March 2018: Orvosi Hetilap
Daniel C Thomas, Brian N Arnold, Jessica R Hoag, Michelle C Salazar, Daniel J Boffa, Frank C Detterbeck, Anthony W Kim, Justin D Blasberg
BACKGROUND: Few studies have examined the risk factors and timing of venous thromboembolism (VTE) in patients undergoing surgery for lung cancer, and there is limited data to formulate guidelines for extended VTE prophylaxis after hospital discharge. This study sought to identify risk factors for post-discharge VTE following lung resection. METHODS: Patients undergoing anatomic resection for lung cancer were identified in the National Surgical Quality Improvement Program database from 2005-2015...
March 1, 2018: Annals of Thoracic Surgery
Joel Bierer, Eustatiu Memu, Robert Leeper, Dalilah Fortin, Eric Fréchette, Richard Inculet, Richard Malthaner
BACKGROUND: Our vision was to develop an inexpensive training simulation in a functional operating room (in-situ) that included surgical trainees, nursing and anesthesia staff to focus on effective interprofessional communication and teamwork skills. METHODS: The simulation scenario revolved around a post-pneumonectomy airway obstruction by residual tumor. This model included our thoracic operating room with patient status displayed by an open access vital sign simulator and a reversibly modified Laerdal® airway mannequin...
February 27, 2018: Annals of Thoracic Surgery
Servet Bölükbas, Robert Zanner, Michael Eberlein, Christian Biancosino, Bassam Redwan
Bronchial sleeve resections are technically demanding procedures compared with lobectomies. In case of bronchial anastomotic dehiscence, secondary pneumonectomy is the treatment of choice. However, a secondary pneumonectomy is usually associated with high morbidity and mortality. Here, we first report, to the best of our knowledge, a secondary lingular sleeve resection following bronchial anastomotic dehiscence after left lower lobe sleeve resection in a patient with a destroyed lobe syndrome due to a pseudotumor...
January 2018: Surgery Journal
Davor Stamenovic, Antje Messerschmidt, Thomas Schneider
BACKGROUND: The prevalence of lung cancer and other tumors is increasing among the elderly people. The purpose of this study was to examine the influence of advanced age (80 + years) on the immediate perioperative outcome as well as to define potential risk factors that may lead to increasing morbidity and mortality after lung resections. METHODS: A retrospective cohort analysis of the data from an electronic database of 208 elderly patients (165 patients ≥70 years, 45 patients ≥80 years) undergoing pulmonary anatomical resection for lung tumors during January 2013-December 2016 was conducted...
February 24, 2018: International Journal of Surgery
Pascal Berna, Bénédicte Toublanc, Alex Fourdrain
Pneumonectomy is known to be associated with high morbidity and mortality, and may be contraindicated in patients with altered lung function. Sleeve lobectomy is a treatment option but may be technically impossible in cases of large bronchial involvement. Here, we describe a patient with impaired lung function and right upper lobe lung cancer involving the intermediate bronchial trunk. He was treated successfully with a right upper sleeve lobectomy and bronchial replacement using a thoracodorsal artery perforator flap and a temporary endostent...
February 24, 2018: Annals of Thoracic Surgery
Benjamin J Resio, Alexander S Chiu, Jessica Hoag, Andrew P Dhanasopon, Justin D Blasberg, Daniel J Boffa
BACKGROUND: Primary Salivary Type Lung Cancers (PSTLC) such as Adenoid Cystic Carcinoma (ACC) and Mucoepidermoid Carcinoma (MEC) are uncommon primary lung tumors that given their rarity, remain incompletely understood. This study aimed to characterize the management and outcomes associated with these less common pulmonary malignancies. METHODS: Patients in the National Cancer Database (NCDB) diagnosed with primary lung and bronchial (not tracheal) MEC and ACC between 2004-2014 were identified...
February 24, 2018: Annals of Thoracic Surgery
Hany M Elrakhawy, Mohamed A Alassal, Ayman M Shaalan, Ahmed A Awad, Sameh Sayed, Mohammad M Saffan
BACKGROUND: Right ventricular (RV) dysfunction after pulmonary resection in the early postoperative period is documented by reduced RV ejection fraction and increased RV end-diastolic volume index. Supraventricular arrhythmia, particularly atrial fibrillation, is common after pulmonary resection. RV assessment can be done by non-invasive methods and/or invasive approaches such as right cardiac catheterization. Incorporation of a rapid response thermistor to pulmonary artery catheter permits continuous measurements of cardiac output, right ventricular ejection fraction, and right ventricular end-diastolic volume...
January 15, 2018: Heart Surgery Forum
Yanjie Wang, Zan Tang, Huanwei Huang, Jiao Li, Zheng Wang, Yuanyuan Yu, Chengwei Zhang, Juan Li, Huaping Dai, Fengchao Wang, Tao Cai, Nan Tang
Pulmonary alveolar type I (AT1) cells cover more than 95% of alveolar surface and are essential for the air-blood barrier function of lungs. AT1 cells have been shown to retain developmental plasticity during alveolar regeneration. However, the development and heterogeneity of AT1 cells remain largely unknown. Here, we conducted a single-cell RNA-seq analysis to characterize postnatal AT1 cell development and identified insulin-like growth factor-binding protein 2 (Igfbp2) as a genetic marker specifically expressed in postnatal AT1 cells...
February 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
Mitsunori Higuchi, Hironori Takagi, Yuki Ozaki, Takuya Inoue, Yuzuru Watanabe, Takumi Yamaura, Mitsuro Fukuhara, Satoshi Muto, Naoyuki Okabe, Yuki Matsumura, Takeo Hasegawa, Jun Osugi, Mika Hoshino, Yutaka Shio, Hiroyuki Suzuki
BACKGROUND: According to previous reports, lobectomy with bronchoplasty or angioplasty is a more feasible surgery than pneumonectomy for central-type non-small cell lung cancer. However, few studies have compared both the short- and long-term outcomes between pneumonectomy and pulmonary function-preserving surgery. METHODS: From January 2004 to December 2015, 18 patients underwent pneumonectomy (Group PN) and 12 patients underwent pulmonary function-preserving surgery (group PS) at Fukushima Medical University Hospital...
February 20, 2018: Fukushima Journal of Medical Science
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