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Pneumonectomy

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https://www.readbyqxmd.com/read/28635203/post-pneumonectomy-and-post-lobectomy-syndromes-case-series-and-review-of-the-literature
#1
Grigoris Stratakos, Vlassis Vitsas, Nikos Koufos, Charalambos Zissis, Philip Emmanouil, Nikos Koulouris
The post-pneumonectomy syndrome is a rare complication consisting of rotation and herniation of the mediastinal structures, the remaining lung and the respective bronchi, into the contralateral hemithorax. This situation may produce symptomatic airway obstruction and varies in its presentation and severity. We describe one case of right and one of left pneumonectomy syndrome as well as one case of post-lobectomy syndrome. We review the literature on the pathophysiology, the clinical, radiological and bronchoscopic characteristics of this rare entity and discuss all available therapeutic alternatives...
May 18, 2017: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/28633250/permeable-nonabsorbable-mesh-for-total-diaphragmatic-replacement-in-extended-pneumonectomy
#2
Luigi Rolli, Giovanni Leuzzi, Paolo Girotti, Leonardo Duranti, Ugo Pastorino
After complex thoracic exenterations, total diaphragmatic resection and reconstruction is challenging. We describe our novel technique for total diaphragmatic replacement with permeable nonabsorbable mesh after extended pneumonectomy.
July 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28622333/acute-40-exchange-transfusion-with-hemoglobin-vesicles-in-a-mouse-pneumonectomy-model
#3
Mitsutomo Kohno, Tatsuhiko Ikeda, Ryo Hashimoto, Yotaro Izumi, Masazumi Watanabe, Hirohisa Horinouchi, Hiromi Sakai, Koichi Kobayashi, Masayuki Iwazaki
OBJECTIVES: Hemoglobin vesicles (HbVs) function as a red blood cell (RBC) substitute and are composed of purified hemoglobin encapsulated in a phospholipid bilayer membrane. The performance of HbVs as a substitute for RBC transfusions was examined in a mouse model of pneumonectomy following acute 40% exchange-transfusion with HbVs. METHODS: Before performing left pneumonectomies, 40% of the blood volume of mice was replaced with a) lactated Ringer's solution (control), b) 5% recombinant human serum albumin (rHSA), c) mouse RBCs shed in rHSA (mRBCs/rHSA), or d) HbV suspended in rHSA (HbV/rHSA)...
2017: PloS One
https://www.readbyqxmd.com/read/28605954/surgical-resection-of-pulmonary-inflammatory-pseudotumors-long-term-outcome
#4
Marine Peretti, Dana M Radu, Karel Pfeuty, Antoine Dujon, Marc Riquet, Emmanuel Martinod
Background Pulmonary inflammatory pseudotumors are rare lesions that remain problematic in several aspects, especially regarding the therapeutic strategy. The goal of this study was to evaluate long-term survival in a multicenter series of patients who required surgery for pulmonary inflammatory pseudotumors. Methods Thirty-six cases of pulmonary inflammatory pseudotumors, operated on in 3 French thoracic surgery departments between 1989 and 2015, were studied retrospectively. We recorded pre-, peri- and postoperative data for each patient, and long-term survival was analyzed...
January 1, 2017: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/28603719/prospective-study-of-quality-of-life-after-lung-cancer-resection
#5
Kathleen G Hopkins, Peter F Ferson, Manisha R Shende, Neil A Christie, Matthew J Schuchert, Arjun Pennathur
BACKGROUND: Surgical resection with curative-intent remains the gold standard for clinically operable early-stage non-small cell lung cancer (NSCLC). This goal can be accomplished using a minimally invasive option, e.g., video assisted thoracic surgery (VATS) or standard thoracotomy. Surgical techniques continue to evolve and few studies have compared the QOL of patients managed with these procedures using current approaches. The primary goal of this study was to investigate differences between patients managed surgically via VATS compared to thoracotomy with respect to ratings of chronic pain, anxiety/depression and quality of life (QOL)...
May 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28596092/stereotactic-body-radiation-therapy-for-early-stage-non-small-cell-lung-cancer-executive-summary-of-an-astro-evidence-based-guideline
#6
Gregory M M Videtic, Jessica Donington, Meredith Giuliani, John Heinzerling, Tomer Z Karas, Chris R Kelsey, Brian E Lally, Karen Latzka, Simon S Lo, Drew Moghanaki, Benjamin Movsas, Andreas Rimner, Michael Roach, George Rodrigues, Shervin M Shirvani, Charles B Simone, Robert Timmerman, Megan E Daly
PURPOSE: This guideline presents evidence-based recommendations for stereotactic body radiation therapy (SBRT) in challenging clinical scenarios in early-stage non-small cell lung cancer (NSCLC). METHODS AND MATERIALS: The American Society for Radiation Oncology convened a task force to perform a systematic literature review on 4 key questions addressing: (1) application of SBRT to operable patients; (2) appropriate use of SBRT in tumors that are centrally located, large, multifocal, or unbiopsied; (3) individual tailoring of SBRT in "high-risk" clinical scenarios; and (4) SBRT as salvage therapy after recurrence...
June 5, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28590338/surgery-as-part-of-radical-treatment-for-malignant-pleural-mesothelioma
#7
David A Waller, Sara Tenconi
PURPOSE OF REVIEW: To review the latest developments in surgery for malignant pleural mesothelioma both in patient selection, surgical technique, and strategy. RECENT FINDINGS: The International Association for the Study of Lung Cancer mesothelioma staging project has produced data to inform the 8th tumour node metastasis revision. The difficulty in clinical N staging and clinical T staging are highlighted and the importance of tumour volume is recognized. New imaging techniques can be utilized to assess tumour volume...
July 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/28577940/trends-practice-patterns-and-underuse-of-surgery-in-the-treatment-of-early-stage-small-cell-lung-cancer
#8
E Wakeam, T K Varghese, N B Leighl, M Giuliani, S R G Finlayson, G E Darling
BACKGROUND: Practice guidelines from the National Comprehensive Cancer Network and the American Society of Clinical Oncology recommend pathologic mediastinal staging and surgical resection for patients with clinically node-negative T1/T2 small cell lung cancer (SCLC), but the extent to which surgery is used is unknown. We sought to assess trends and practice patterns in the use of surgery for SCLC. METHODS: T1 or T2N0M0 SCLC cases were identified in the National Cancer Database (NCDB), 2004-2013...
July 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28573429/predictors-of-outcome-in-101-patients-requiring-emergent-thoracotomy-for-penetrating-pulmonary-injuries
#9
J A Asensio, O A Ogun, F N Mazzini, A J Perez-Alonso, L M Garcia-Núñez, P Petrone
BACKGROUND: Operative interventions are uncommonly required for penetrating pulmonary injuries. Similarly, because their incidence is low, few series appear sporadically in the literature. Objectives of this study are to identify predictors of outcome for patients requiring emergent thoracotomy for penetrating pulmonary injuries and evaluate the use of tissue sparing versus resective techniques for their management. STUDY DESIGN: This is a retrospective 169-month study of all patients with penetrating pulmonary injuries requiring thoracotomy...
June 1, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28570153/managing-post-pneumonectomy-tension-hydrothorax
#10
Erik Vakil, Saadia A Faiz, Cezar Iliescu, Diwakar D Balachandran, Philip Ong, Labib Gilles Debiane, Reza Mehran
No abstract text is available yet for this article.
June 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28565853/comparison-of-acute-phase-protein-and-hemodynamic-variables-in-dogs-undergoing-video-assisted-thoracoscopic-vs-open-pneumonectomy
#11
Hai-Feng Liu, Qing-Ming Ren, Zhi-Bo Wang, Xin Li, Sheng Jiang, Jian-Tao Zhang, Hong-Bin Wang
It has been demonstrated that video-assisted thoracoscopic surgery (VATS) is feasible and safe in humans and animal models. The aim of the present study was to compare the surgical outcome using VATS with that of the standard transthoracic approach for pneumonectomy in dogs, to determine the acute-phase reaction in VATS pneumonectomy, and to analyze the difference between VATS and the standard transthoracic approach. A total of 14 dogs were divided into two groups (n=7); one group underwent VATS and the other group underwent a transthoracic pneumonectomy...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28561723/wedge-resection-versus-anatomic-resection-extent-of-surgical-resection-for-stage-i-and-ii-lung-cancer
#12
Hisao Asamura, Keiju Aokage, Masaya Yotsukura
Currently, surgery for lung cancer with curative intent consists of resection (removal) of the proper extent of lung parenchyma that bears the cancer lesion along with locoregional lymph nodes to assess possible cancer metastasis. Lobectomy, at least, is preferred with regard to the extent of parenchymal resection. The history of lung cancer surgery, which started around 1933 as pneumonectomy (resection of the entire lung on either side), can be characterized as an attempt to minimize the extent of parenchymal resection...
2017: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/28552766/the-influence-of-body-mass-index-on-overall-survival-following-surgical-resection-of-non-small-cell-lung-cancer
#13
Boris Sepesi, Kathryn A Gold, Arlene M Correa, John V Heymach, Ara A Vaporciyan, Jason Roszik, Ethan Dmitrovsky, Xi Liu
BACKGROUND: Population studies suggest that high body mass index (BMI) correlates with a reduced risk of death from lung cancer. The aim of our study was to evaluate definitively the influence of BMI on long term overall survival (OS) in surgical patients with non-small cell lung cancer (NSCLC). METHODS: Study population consisted of 1935 patients who underwent surgical resection for lung cancer at MD Anderson Cancer Center (2000-2014). Study variables included both patient and treatment related characteristics...
May 25, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28550923/concordant-pattern-of-radiologic-morphologic-and-genomic-changes-during-compensatory-lung-growth
#14
Takamasa Ito, Hidemi Suzuki, Hironobu Wada, Taiki Fujiwara, Takahiro Nakajima, Takekazu Iwata, Shigetoshi Yoshida, Ichiro Yoshino
BACKGROUND: Although compensatory lung growth (CLG) after lung resection has been reported in various mammalian species, it has generally been thought that the lung cannot regenerate in adult humans. We recently developed a method for evaluating lung weight using a radiologic analysis and demonstrated that the lung was heavier than expected in adult humans after pulmonary resection. In this study, we serially evaluated the morphologic, radiologic, and genomic status during CLG in pneumonectomized mice...
May 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28550900/technique-and-perioperative-management-of-left-pneumonectomy-in-neonatal-piglets
#15
Duy T Dao, Lorenzo Anez-Bustillos, Alison A O'Loughlin, Amy Pan, Arthur P Nedder, Dana Bolgen, Charles Jason Smithers, Jill Zalieckas, Craig W Lillehei, Prathima Nandivada, Meredith A Baker, Gillian L Fell, Bennet S Cho, Mark Puder
BACKGROUND: Although commonly performed in adult swine, unilateral pneumonectomy in piglets requires significant modifications in the surgical approach and perioperative care because of their smaller size and limited physiological reserve. METHODS: Nineteen neonatal piglets underwent a left pneumonectomy. They were allowed 5-7 d of preoperative acclimation and nutritional optimization. Preoperative weight gain and laboratory values were obtained before the time of surgery...
May 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28549671/the-outcome-of-extracorporeal-life-support-after-general-thoracic-surgery-timing-of-application
#16
Heemoon Lee, Yang Hyun Cho, Hyoung Woo Chang, Ji-Hyuk Yang, Jong Ho Cho, Kiick Sung, Young Tak Lee
BACKGROUND: Extracorporeal life support (ECLS) is widely used in refractory cardiac or pulmonary failure. Because complications of general thoracic surgery frequently involve the heart or lungs, ECLS can be a useful option. Therefore, we retrospectively reviewed our experience with ECLS after general thoracic surgery. METHODS: There were 17,185 adult general thoracic surgery procedures between 2005 and 2013 at our institution, including resection of the lung (n = 10,434; 60...
May 24, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28543219/prognostic-value-of-visceral-pleural-invasion-in-non-small-cell-lung-cancer-a-propensity-score-matching-study-based-on-the-seer-registry
#17
Xiaodong Yang, Fenghao Sun, Li Chen, Mengkun Shi, Yu Shi, Zongwu Lin, Mingxiang Feng, Cheng Zhan, Wei Jiang, Qun Wang
BACKGROUND AND OBJECTIVES: Visceral pleural invasion (VPI) is considered a poor prognostic factor in non-small cell lung cancer (NSCLC). We aimed to analyze the effect of VPI on cancer-specific survival, using propensity score matching (PSM) based on the Surveillance, Epidemiology, and End Results database. METHODS: We identified 9901 patients with T1-2N0-2M0 who received segmentectomy, lobectomy, or pneumonectomy. Ten covariates were included in PSM. The effect of VPI on survival was assessed, stratified by nodal status and tumor size...
May 22, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28542402/evidence-for-pleural-epithelial-mesenchymal-transition-in-murine-compensatory-lung-growth
#18
Alexandra B Ysasi, Willi L Wagner, Cristian D Valenzuela, Arne Kienzle, Andrew B Servais, Robert D Bennett, Akira Tsuda, Maximilian Ackermann, Steven J Mentzer
In many mammals, including rodents and humans, removal of one lung results in the compensatory growth of the remaining lung; however, the mechanism of compensatory lung growth is unknown. Here, we investigated the changes in morphology and phenotype of pleural cells after pneumonectomy. Between days 1 and 3 after pneumonectomy, cells expressing α-smooth muscle actin (SMA), a cytoplasmic marker of myofibroblasts, were significantly increased in the pleura compared to surgical controls (p < .01). Scanning electron microscopy of the pleural surface 3 days post-pneumonectomy demonstrated regions of the pleura with morphologic features consistent with epithelial-mesenchymal transition (EMT); namely, cells with disrupted intercellular junctions and an acquired mesenchymal (rounded and fusiform) morphotype...
2017: PloS One
https://www.readbyqxmd.com/read/28540630/surgery-for-malignant-lesions-of-the-chest-which-extensively-involved-the-mediastinum-lung-and-heart
#19
REVIEW
Yugo Tanaka, Daisuke Hokka, Hiroyuki Ogawa, Nahoko Shimizu, Takeshi Inoue, Hiroshi Tanaka, Yutaka Okita, Yoshimasa Maniwa
OBJECTIVE: Radical resection for thoracic malignancies that invade the great vessels or heart structure is an uncommon, high-risk operation. To help surgeons determine therapeutic strategy, we reviewed the patient characteristics and outcomes of combined thoracic and cardiovascular surgery for thoracic malignancies. METHODS: Surgical resections of lung cancer, mediastinal tumor and pulmonary artery sarcoma invading great vessels or heart structures were reviewed from the literature...
May 24, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28528059/diode-pumped-laser-for-lung-sparing-surgical-treatment-of-malignant-pleural-mesothelioma
#20
Servet Bölükbas, Christian Biancosino, Bassam Redwan, Michael Eberlein
Surgical resection represents one of the essential cornerstones in multimodal treatment of malignant pleural mesothelioma. In cases of tumor infiltration of the lung, lung-scarifying procedures such as lobectomies or pneumonectomies might be necessary to achieve macroscopic complete resection. However, this increases the morbidity of the patients because it leads to possible delay of the planned chemotherapy or radiotherapy. Innovative surgical techniques are therefore required to enable salvage of the lung parenchyma and optimization of surgical treatment...
June 2017: Annals of Thoracic Surgery
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