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https://www.readbyqxmd.com/read/29150034/lung-resection-in-the-postpneumonectomy-patient
#1
REVIEW
Megumi Asai, Walter J Scott
Pulmonary resection after pneumonectomy is a reasonable option in selected patients. Wedge resection for single peripheral metachronous disease has the best outcome with 5-year survival as high as 63%. Current and predicted postoperative cardiopulmonary reserve should be evaluated carefully. Stereotactic body radiotherapy is a promising alternative for inoperable patients.
February 2018: Thoracic Surgery Clinics
https://www.readbyqxmd.com/read/29146157/angiotensin-converting-enzyme-2-activation-ameliorates-pulmonary-endothelial-dysfunction-in-rats-with-pulmonary-arterial-hypertension-through-mediating-phosphorylation-of-endothelial-nitric-oxide-synthase
#2
Gang Li, Han Zhang, Lei Zhao, Yaozhong Zhang, Daole Yan, Yinglong Liu
This study aims to investigate the effect of angiotensin-converting enzyme 2 (ACE2) activation on pulmonary endothelial function in the process of preventing pulmonary arterial hypertension (PAH) in rat models and to explore the underlying mechanisms. Specific pathogen free rats were randomly divided into five groups including control group, PAH group, PAH + Resorcinolnaphthalein (Res) group (ACE2 activation), PAH + Res + MLN4760 group (ACE2 inhibition), and PAH + Res + L-NAME group (endothelial nitric oxide synthase [eNOS] inhibition)...
October 28, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29138553/the-protective-effect-of-prmt6-overexpression-on-cigarette-smoke-extract-induced-murine-emphysema-model
#3
Xue He, Tiao Li, Naixin Kang, Huihui Zeng, Siying Ren, Dandan Zong, Jinhua Li, Shan Cai, Ping Chen, Yan Chen
Background: Cigarette smoke exposure is the most common risk factor for emphysema, which is one of the major pathologies of COPD. Protein arginine methyltransferase 6 (PRMT6) is a nuclear enzyme that specially catalyzes dimethylation of R2 in histone H3 (H3R2me2a). H3R2me2a prevents trimethylation of H3K4 (H3K4me3), which is located in the transcription start sites of genes in mammalian genomes. We attempted to determine the expression of PRMT6 in human samples, and investigate whether the upregulation of PRMT6 expression can attenuate the development of cigarette smoke extract (CSE)-induced emphysema...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29131765/comprehensive-cross-sectional-imaging-of-the-pulmonary-veins
#4
Cameron Hassani, Farhood Saremi
The pulmonary veins carry oxygenated blood from the lungs to the heart, but their importance to the radiologist extends far beyond this seemingly straightforward function. The anatomy of the pulmonary veins is variable among patients, with several noteworthy variant and anomalous patterns, including supernumerary pulmonary veins, a common ostium, anomalous pulmonary venous return, and levoatriocardinal veins. Differences in pulmonary vein anatomy and the presence of variant or anomalous anatomy can be of critical importance, especially for preoperative planning of pulmonary and cardiac surgery...
November 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29124035/successful-tractotomy-technique-for-a-penetrating-lung-injury-in-a-patient-with-one-lung
#5
Dong Hoon Kang, Hyun Oh Park, Sung Ho Moon, In Seok Jang, Jung Hoon Byun, Sung Hwan Kim
We report the case of a patient with penetrating chest trauma (right chest) who had undergone a left pneumonectomy due to pulmonary tuberculosis 24 years ago. We performed an emergent thoracotomy, finding an opening of the penetrating wound in a lower-lobe basal segment of the right lung. A stapled tractotomy was performed along the tract. Bleeding control and air-leakage control was done easily and rapidly. The patient was discharged without any complications on the seventh day of admission. Tractotomy can be a good option for treating penetrating lung injuries in patients with limited lung function who need emergent surgery...
October 2017: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29124033/intraoperative-recurrent-laryngeal-nerve-monitoring-in-a-patient-with-contralateral-vocal-fold-palsy
#6
Bub-Se Na, Jin-Ho Choi, In Kyu Park, Young Tae Kim, Chang Hyun Kang
Recurrent laryngeal nerve injury can develop following cervical or thoracic surgery; however, few reports have described intraoperative recurrent laryngeal nerve monitoring. Consensus regarding the use of this technique during thoracic surgery is lacking. We used intraoperative recurrent laryngeal nerve monitoring in a patient with contralateral vocal cord paralysis who was scheduled for completion pneumonectomy. This case serves as an example of intraoperative recurrent laryngeal nerve monitoring during thoracic surgery and supports this indication for its use...
October 2017: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29119018/metastasectomy-in-pediatric-patients-indications-technical-tips-and-outcomes
#7
REVIEW
Paolo Scanagatta, Lara Girelli
Pulmonary metastasectomy has become a standard procedure for pediatric patients with certain types of solid tumors. Surgeons, expert pediatric oncologists and radiation oncologists contribute with their different skills to the management of pulmonary metastases. Patients are usually scheduled for surgery in case of primary tumor control, in absence of metastases in other organs and when a complete resection is achievable. Nodules are removed through precision resections using electrocautery or laser methods in order to ensure radical surgery with adequate margins...
October 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29119012/prognostic-factors-after-pulmonary-metastasectomy-of-colorectal-cancers-a-single-center-experience
#8
Ludovic Fournel, Stefania Maria, Marie Seminel, Jessica Nesci, Audrey Mansuet-Lupo, Claude Guinet, Pierre Magdeleinat, Antonio Bobbio, Jean-François Regnard, Marco Alifano
Background: Surgical resection has been widely admitted as the treatment of choice for pulmonary metastases of colorectal cancer (CRC). Nevertheless, this practice is not supported by high level of evidence and patients' eligibility remains controversial. Aim of this study was to evaluate long terms results and factors influencing survival after lung metastasectomy of CRC. Methods: A single-center retrospective analysis of patients with pathologically proven colorectal metastasis, operated from 2004 to 2013, was performed...
October 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29114998/early-and-delayed-post-pneumonectomy-empyemas-microbiology-management-and-prognosis
#9
Jean-Baptiste Stern, Ludovic Fournel, Benjamin Wyplosz, Philippe Girard, Malik AlNakib, Dominique Gossot, Agathe Seguin-Givelet
INTRODUCTION: Post-pneumonectomy empyema (PPE) is the most severe complication of pneumonectomy. Microbiology and its impact on management and prognosis have rarely been reported Methods: We retrospectively reviewed the files of a series of 37 consecutive patients with PPE over a 10-year period with a special focus on microbiology, means used to treat empyema, and prognosis. RESULTS: PPE occurred within 14 days of pneumonectomy in 17 cases (early PPE) and after postoperative day 16 in 20 patients (delayed PPE)...
November 8, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29109057/broncho-pleural-fistula-after-pneumonectomy-risk-factors-and-management-focusing-on-open-window-thoracostomy
#10
Antonio Mazzella, Alessandro Pardolesi, Patrick Maisonneuve, Francesco Petrella, Domenico Galetta, Roberto Gasparri, Lorenzo Spaggiari
OBJECTIVE: We evaluated principal risk factors and different therapeutic approaches for post-pneumonectomy broncho-pleural fistula (BPF), focusing on open window thoracostomy (OWT). METHODS: We have retrospectively reviewed all patients treated by pneumonectomy for lung cancer from 1999 to 2014; we evaluated preoperative, operative and postoperative data, time between operation and fistula formation, size, treatment and predicting factors of BPF. Cumulative incidence curves for the development of BPF were drawn according to the Kaplan-Meier Method...
November 3, 2017: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29106810/stereotactic-body-radiotherapy-for-early-stage-non-small-cell-lung-cancer-american-society-of-clinical-oncology-endorsement-of-the-american-society-for-radiation-oncology-evidence-based-guideline
#11
Bryan J Schneider, Megan E Daly, Erin B Kennedy, Mara B Antonoff, Stephen Broderick, Jill Feldman, Shruti Jolly, Bryan Meyers, Gaetano Rocco, Chad Rusthoven, Ben J Slotman, Daniel H Sterman, Brendon M Stiles
Purpose The American Society for Radiation Oncology (ASTRO) produced an evidence-based guideline on treatment with stereotactic body radiotherapy (SBRT) for patients with early-stage non-small-cell lung cancer. ASCO has a policy and set of procedures for endorsing and/or adapting clinical practice guidelines that have been developed by other professional organizations. Methods The ASTRO Evidence-Based Guideline for Stereotactic Body Radiotherapy for Early-Stage Non-Small-Cell Lung Cancer was reviewed for developmental rigor by methodologists...
November 6, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29106507/pedicled-and-free-flaps-for-intrathoracic-fistula-management
#12
Alba Fricke, Holger Bannasch, Henriette F Klein, Sebastian Wiesemann, Patrick Samson-Himmelstjerna, Bernward Passlick, Friedhelm Beyersdorf, Jens Hoeppner, Vincenzo Penna, Steffen U Eisenhardt, Björn G Stark, Georgios Koulaxouzidis
OBJECTIVES: Intrathoracic fistulae are among the potential sequelae of radiation therapy, empyema and abscess clearance and surgical tumour resections. Interdisciplinary plastic-reconstructive flap surgery is a helpful tool for the successful treatment of intrathoracic fistulae. METHODS: From February 2006 to April 2016, 13 patients (3 females and 10 males) underwent flap surgery for bronchial ( n  = 5), tracheal ( n  = 2), oesophageal ( n  = 2), post-pneumonectomy bronchopleural fistula ( n  = 2), tracheo-oesophageal ( n  = 1), gastrobronchial ( n  = 1) and oesophagobronchial ( n  = 1) fistulae...
July 4, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29103816/all-grades-of-severity-of-postoperative-adverse-events-are-associated-with-prolonged-length-of-stay-after-lung-cancer-resection
#13
Zach Zhang, Fargol Mostofian, Jelena Ivanovic, Sebastien Gilbert, Donna E Maziak, Farid M Shamji, Sudhir Sundaresan, Patrick J Villeneuve, Andrew J E Seely
OBJECTIVE: To determine whether all grades of severity of postoperative adverse events are associated with prolonged length of stay in patients undergoing pulmonary cancer resection. METHODS: This was a retrospective cohort study of all patients who underwent pulmonary resection with curative intent for malignancy at The Ottawa Hospital, Division of Thoracic Surgery (January 2008 to July 2015). Postoperative adverse events were collected prospectively with the Thoracic Morbidity & Mortality System, based on the Clavien-Dindo severity classification...
September 28, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29103238/neo-adjuvant-chemo-radiation-to-60-gray-followed-by-surgery-for-locally-advanced-non-small-cell-lung-cancer-patients-evaluation-of-trimodality-strategy
#14
Sarit Appel, Jeffry Goldstein, Marina Perelman, Tatiana Rabin, Damien Urban, Amir Onn, Tiberiu R Shulimzon, Ilana Weiss, Sivan Lieberman, Edith M Marom, Nir Golan, David Simansky, Alon Ben-Nun, Yaacov Richard Lawrence, Jair Bar, Zvi Symon
BACKGROUND: Neoadjuvant chemo-radiation therapy (CRT) dosages in locally advanced non-small cell lung cancer (NSCLC) were traditionally limited to 45 Gray (Gy). OBJECTIVES: To retrospectively analyze outcomes of patients treated with 60 Gy CRT followed by surgery. METHODS: A retrospective chart review identified patients selected for CRT to 60 Gy followed by surgery between August 2012 and April 2016. Selection for surgery was based on the extent of disease, cardiopulmonary function, and response to treatment...
October 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29093247/-clinical-analysis-for-bronchopleural-fistula-after-lung-resections
#15
Yun Chen, Xiong Peng, Yanqing Wang, Yuan Zhou, Kun Xia, Wei Zhuang
To explore the risk factors, preventive measures and therapeutic methods for bronchopleural fistula (BPF) after lung resections.
 Methods: A restrospective analysis for 11 patients with BPF after pneumonectomy from April 2012 to June 2016 in Department of Thoracic Surgery, Xiangya Hospital, Central South University was performed. Their clinical characteristics, treatment and prognosis were analyzed, and the risk factors and effective therapeutic strategies were summarized.
 Results: Among the 11 patients with BPF, 10 cases were cured finally, and 1 case with conservative treatment was dead...
October 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29089718/evarts-ambrose-graham-and-the-first-successful-pneumonectomy-a-brief-account
#16
Esha Pai, Tarun Kumar
No abstract text is available yet for this article.
October 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29083020/video-assisted-thoracoscopic-bronchial-sleeve-lobectomy-a-case-report
#17
Marcin Ostrowski, Tomasz Marjański, Witold Rzyman
Bronchial sleeve lobectomy offers a chance to avoid excessive resections such as pneumonectomy in central lung tumors. Recent technical advances enable complex procedures such as video-assisted thoracoscopic bronchial sleeve lobectomy (VABSL). We present a case of a 64-year-old patient who underwent the right upper VABSL due to adenocarcinoma. During resection the bronchus was transsected and a specimen removed due to tumor proximity. Intraoperative frozen section revealed no neoplastic infiltration in the bronchial cut line...
October 30, 2017: Advances in Respiratory Medicine
https://www.readbyqxmd.com/read/29078690/single-port-video-assisted-thoracoscopic-surgery-vats-right-pneumonectomy-a-case-report
#18
Matic Domjan, Ana Mavko, Tomaž Štupnik
When it comes to surgical treatment of non-small cell lung cancer (NSCLC), modern principles dictate that every possible effort should be made to avoid pneumonectomy, its debilitating consequences and a higher rate of complications. In marginal cases where video-assisted thoracoscopic surgery (VATS) sleeve or double sleeve lobectomy cannot be performed a conversion to open sleeve lobectomy is always preferred over a VATS pneumonectomy. We present a case of a 64-year-old male patient with two synchronous tumors of the right lung, both centrally located in the right upper and the right lower lobe...
2017: J Vis Surg
https://www.readbyqxmd.com/read/29078648/video-assisted-thoracoscopic-and-open-chest-surgery-in-diagnosis-and-treatment-of-malignant-pleural-diseases
#19
REVIEW
Periklis Perikleous, David A Waller
Parenchymal cancers of lung, breast, gastrointestinal tract and ovaries as well as lymphomas and mesotheliomas are among the most common cancer types causing malignant effusions, though almost all tumour types have been reported to cause a malignant effusion. The prognosis heavily depends on patients' response to systemic therapy however, regardless of the causing pathology and histopathologic form, malignant pleural disease is normally associated with a poor prognosis. To date, there are not sufficient data to allow accurate predictions of survival that would facilitate decision making for managing patients with malignant pleural diseases...
2017: J Vis Surg
https://www.readbyqxmd.com/read/29078614/intra-pericardial-double-sleeve-uniportal-video-assisted-thoracoscopic-surgery-left-upper-lobectomy
#20
Firas Abu Akar, Chenlu Yang, Lei Lin, Shi Jia Min, Lei Jiang
The importance of parenchymal tissue preservation during lung resections is well realized in thoracic surgery. Technical refinement and anatomic insight have expanded indications for parenchymal -sparing surgeries. In thoracic surgery, it's reasonable to avoid pneumonectomy whenever it's possible, although challenging and technically more demanding than standard anatomic pulmonary resection, bronchial and/or vascular resection of a circumferential portion (sleeve resections) is a justified procedure due to its benefits of avoiding the complications of pneumonectomy in addition to preservation of pulmonary tissue and functions...
2017: J Vis Surg
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