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Pneumonectomy

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https://www.readbyqxmd.com/read/28729039/congenital-myopathy-due-to-myosin-heavy-chain-2-mutation-presenting-as-chronic-aspiration-pneumonia-in-infancy
#1
R Tsabari, H Daum, E Kerem, Y Fellig, T Dor
A 7-week-old infant presented with persistent noisy breathing and aspirations during swallowing. Neurological examination and brain MRI were normal. His 12-year-old brother underwent pneumonectomy at the age of 10 years due to recurrent aspirations leading to severe lung damage. The older brother developed subsequently ophthalmoplegia and nystagmus along with mild weakness of the neck flexors and proximal muscles. Exome analysis revealed homozygosity for a novel truncating mutation p.G800fs27* in the Myosin Heavy Chain 2 (MYH2) gene in both brothers, while parents and an unaffected sibling were heterozygous...
June 27, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/28723786/risk-factors-of-lymph-node-metastasis-in-lung-squamous-cell-carcinoma-of-3%C3%A2-cm-or-less-in-diameter
#2
Lijian Huang, Wenshan Li, Lufeng Zhao, Baizhou Li, Ying Chai
Through literature review we cannot find an efficient risk factor of lymph node metastasis in lung squamous cell carcinoma (SCC). This study aimed to investigate the risk factors of pathological lymph node status in patients with lung SCC of 3 cm or less in diameter, to provide some reference for the fellow surgeons in the decision of operative option.In total, we analyzed 154 patients with lung SCC of 3 cm or less in diameter who underwent lobectomy or bilobectomy or pneumonectomy with systematic lymph node dissection...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28723756/pulmonary-pleomorphic-carcinoma-a-case-report-and-review-of-the-literature
#3
Xiangwei Zhang, Yang Wang, Linping Zhao, Haiyan Jing, Shaowei Sang, Jiajun Du
RATIONALE: Pleomorphic carcinoma (PC) is a rare malignancy of the lung. It has a dual-cell component of spindle and/or giant cells, and of epithelial cells. PATIENT CONCERNS AND DIAGNOSES: We presented a case of PC. A 69-year-old healthy asymptomatic woman who was occasionally found an abnormal shadow on her chest X-rays. A computerized tomography scan showed a mass located in the left lingular lobe and the percutaneous lung biopsy pathology confirmed sarcomatoid cancer...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28721193/giant-spontaneous-herniation-of-the-post-pneumonectomy-cavity
#4
Alessandro Tamburrini, Adnan Raza, Aiman Alzetani
Following a pneumonectomy, excessive mediastinal shift can cause rare complications involving the post-pneumonectomy cavity, which can become the seat of herniation of the residual lung and of the heart. We herein report an even more rare event, entailing an impressive herniation of the actual entire post-pneumonectomy cavity through an intercostal space, which developed spontaneously nearly 3 years after surgery. Surgical excision of the hernia sac and repair of the defect with polypropylene mesh provided adequate treatment and good cosmetic results...
July 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28718917/proliferation-of-elastic-fibers-in-idiopathic-pulmonary-fibrosis-a-whole-slide-image-analysis-and-comparison-with-pleuroparenchymal-fibroelastosis
#5
Yoshiaki Kinoshita, Kentaro Watanabe, Hiroshi Ishii, Hisako Kushima, Masaki Fujita, Kazuki Nabeshima
BACKGROUND: We occasionally encounter patients with idiopathic pulmonary fibrosis (IPF) who have similar imaging patterns to pleuroparenchymal fibroelastosis (PPFE) in the upper lung fields but are not diagnosed as PPFE clinically. The clinicopathological features and intrapulmonary distribution of elastic fibers and collagen fibers in these patients have not been fully elucidated. METHODS: We retrospectively reviewed the medical records of patients with a clinical diagnosis of IPF and selected the consecutive patients who received autopsy or pneumonectomy for lung transplantation...
July 18, 2017: Histopathology
https://www.readbyqxmd.com/read/28711822/extended-thymectomy-left-pneumonectomy-pericardiectomy-and-partial-pleurectomy-for-a-large-thymoma-using-only-a-median-sternotomy
#6
Jorge Cruz, André Sena, Catarina Carvalheiro, Ricardo Ferreira
We present a case of a large thymoma with invasion to the hilum of the lung and pleural dissemination. A 58-year-old woman was diagnosed with a type B2 thymoma, with suspected pericardium, pulmonary artery and left lung invasion and pleural metastasis (Masaoka-Koga stage IVb). A radical resection was planned after systemic chemotherapy. Through a median sternotomy, we resected the tumour, and after confirmation of pericardium and left lung invasion, we also performed resection of the pericardium, of the lung and of the pleural metastasis...
June 29, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28709663/pulmonary-resection-for-second-lung-cancer-after-pneumonectomy-a-population-based-study
#7
Adil Ayub, Sadiq S Rehmani, Adnan M Al-Ayoubi, Wissam Raad, Raja M Flores, Faiz Y Bhora
BACKGROUND: Pulmonary resection for a second lung cancer after pneumonectomy is generally considered to be at prohibitive risk. Using a population-based database, we examined treatment patterns and survival in patients who underwent pulmonary resection after pneumonectomy for lung cancer. METHODS: We queried the Surveillance, Epidemiology, and End Results (SEER) database (1988-2012) to identify patients who underwent pneumonectomy and subsequently experienced contralateral non-small cell lung cancer (NSCLC)...
July 11, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28706910/malignant-pleural-mesothelioma-adjuvant-therapy-with-radiation-therapy
#8
REVIEW
Kenneth E Rosenzweig
It is a challenge to treat malignant pleural mesothelioma with radiation therapy (RT). For many years, conventional RT was delivered after extrapleural pneumonectomy (EPP) with acceptable results. However, the benefit of RT has never been definitively proven. Intensity modulated radiation therapy (IMRT) has been used, but some of the early experiences revealed fatal toxicity. As experience has increased, it now appears that RT, particularly with IMRT, is both feasible and effective.
June 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28706905/a-nuanced-view-of-extrapleural-pneumonectomy-for-malignant-pleural-mesothelioma
#9
REVIEW
Isabelle Opitz, Walter Weder
Multimodality treatment including macroscopic complete resection (MCR) is currently the most effective therapy for patients with malignant pleural mesothelioma (MPM). However, the allocation to one of the possible combinations has to be discussed individually since various factors influence the decision making process. In the past years, relevant new information about the disease and the outcome of different treatment modalities have been generated, which allows a more individual allocation to the best treatment...
June 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28706901/intraoperative-intracavitary-hyperthermic-chemotherapy-for-malignant-pleural-mesothelioma
#10
REVIEW
Kazunori Okabe
Malignant pleural mesothelioma (MPM) is a dreadful disease with a poor prognosis. Multimodality therapy including surgical macroscopic complete resection is performed to treat operable MPM. Intraoperative intracavitary hyperthermic chemotherapy for MPM was reviewed. Appropriate papers published between 2006 and present were extracted by the PubMed advanced search by MPM (Title/Abstract), chemotherapy (Title/Abstract), and hyperthermia (All fields). Among the selected papers, those written in English, and treated more than ten MPM patients were reviewed...
June 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28706900/extrapleural-pneumonectomy-epp-vs-pleurectomy-decortication-p-d
#11
REVIEW
Hasan Fevzi Batirel
Surgical techniques for treatment of malignant pleural mesothelioma (MPM) have improved over the decades. The main surgical principle was accepted as macroscopic complete resection. This principle was achieved with extrapleural pneumonectomy (EPP) and extended pleurectomy/decortication (P/D). Mortality and morbidity are higher following EPP with supraventricular arrhythmias, pulmonary embolism, bronchopleural fistula and pulmonary failure being the most common, while prolonged air leak is frequent following P/D...
June 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28706898/the-impact-of-surgical-approach-on-quality-of-life-for-pleural-malignant-mesothelioma
#12
Rebecca M Schwartz, Alexis Watson, Andrea Wolf, Raja Flores, Emanuela Taioli
BACKGROUND: A comprehensive review of quality of life (QoL) after surgery for malignant pleural mesothelioma (MPM) was conducted to assess differences between pleurectomy decortication (P/D) and extrapleural pneumonectomy (EPP). METHODS: Original research studies on quality of life after mesothelioma surgery were identified through June 2016; 15 articles and 12 distinct datasets, for a total of 523 patients, were retrieved. RESULTS: QoL data was available for 102 patients treated with EPP and 296 with P/D...
June 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28697892/bronchopleural-fistula-after-pneumonectomy-risk-factors-and-management-focusing-on-open-window-thoracostomy
#13
Antonio Mazzella, Alessandro Pardolesi, Patrick Maisonneuve, Francesco Petrella, Domenico Galetta, Roberto Gasparri, Lorenzo Spaggiari
OBJECTIVE: To evaluate principal risk factors and different therapeutic approaches for postpneumonectomy bronchopleural fistula (BPF), focusing on open window thoracostomy (OWT). METHODS: We retrospectively reviewed all patients treated by pneumonectomy for lung cancer between 1999 and 2014. We evaluated preoperative, operative, and postoperative data; interval between operation and fistula formation; and size, treatment, and predicting factors of BPF. Cumulative incidence curves for the development of BPF were drawn according to the Kaplan-Meier method...
June 12, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28684003/surgical-treatment-of-superior-sulcus-tumors-a-15-year-single-center-experience
#14
Piergiorgio Solli, Monica Casiraghi, Daniela Brambilla, Patrick Maisonneuve, Lorenzo Spaggiari
This paper reports on the characteristics, treatment modalities, and outcomes of patients with superior sulcus tumors who underwent surgery over a period of 15 years in 1 institution. Clinical records of 94 consecutive patients operated on by the same surgical team for non-small cell lung cancer between July 1998 and December 2013 were retrospectively reviewed. All patients received lung and chest wall en bloc resection. Forty-eight (51%) received induction treatments. Surgery was an anterior approach in 46 patients (48...
April 2017: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28680568/combined-oral-administration-of-l-arginine-and-tetrahydrobiopterin-in-a-rat-model-of-pulmonary-arterial-hypertension
#15
C Schreiber, M S Eilenberg, A Panzenboeck, M P Winter, H Bergmeister, R Herzog, J Mascherbauer, I M Lang, D Bonderman
Alterations in the nitric oxide (NO) pathway play a major role in pulmonary arterial hypertension (PAH). L-arginine (LA) and tetrahydrobiopterin (BH4) are main substrates in the production of NO, which mediates pulmonary vasodilation. Administration of either LA or BH4 decrease pulmonary artery pressure (PAP). A combined administration of both may have synergistic effects in the therapy of PAH. In a telemetrically monitored model of unilateral pneumonectomy and monocrotaline-induced PAH, male Sprague-Dawley rats received either LA (300 mg/kg; n = 15), BH4 (20 mg/kg; n = 15), the combination of LA and BH4 (300 mg/kg, 20 mg/kg; n = 15), or vehicle (control group; n = 10) from day 28 after monocrotaline induction...
March 2017: Pulmonary Circulation
https://www.readbyqxmd.com/read/28679393/nuclear-factor-kappa-b-influences-early-phase-of-compensatory-lung-growth-after-pneumonectomy-in-mice
#16
Yusuke Takahashi, Noriyuki Matsutani, Hitoshi Dejima, Takashi Nakayama, Hirofumi Uehara, Masafumi Kawamura
BACKGROUND: Compensatory lung growth (CLG) is a well-established lung regeneration model. However, the sequential mechanisms, including unknown molecular triggers or regulators, remain unclear. Nuclear factor- kappa B (NF-κB) is known to be essential for inflammation and tissue regeneration; therefore, we investigated the role of NF-κB in CLG. METHODS: C57BL/6 J mice underwent either a left pneumonectomy or a thoracotomy (n = 77). Gene microarray analysis was performed to detect genes that were upregulated at 12 h after pneumonectomy...
July 5, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28638160/low-flow-extracorporeal-carbon-dioxide-removal-using-the-hemolung-respiratory-dialysis-system-%C3%A2-to-facilitate-lung-protective-mechanical-ventilation-in-acute-respiratory-distress-syndrome
#17
Bindu Akkanti, Keshava Rajagopal, Kirti P Patel, Sangeeta Aravind, Emmanuel Nunez-Centanu, Rahat Hussain, Farshad Raissi Shabari, Wayne L Hofstetter, Ara A Vaporciyan, Igor S Banjac, Biswajit Kar, Igor D Gregoric, Pranav Loyalka
Extracorporeal carbon dioxide removal (ECCO2R) permits reductions in alveolar ventilation requirements that the lungs would otherwise have to provide. This concept was applied to a case of hypercapnia refractory to high-level invasive mechanical ventilator support. We present a case of an 18-year-old man who developed post-pneumonectomy acute respiratory distress syndrome (ARDS) after resection of a mediastinal germ cell tumor involving the left lung hilum. Hypercapnia and hypoxemia persisted despite ventilator support even at traumatic levels...
June 2017: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/28635203/post-pneumonectomy-and-post-lobectomy-syndromes-case-series-and-review-of-the-literature
#18
Grigoris Stratakos, Vlassis Vitsas, Nikos Koufos, Charalambos Zissis, Philip Emmanouil, Nikos Koulouris
The post-pneumonectomy syndrome is a rare complication consisting of rotation and herniation of the mediastinal structures, the remaining lung and the respective bronchi, into the contralateral hemithorax. This situation may produce symptomatic airway obstruction and varies in its presentation and severity. We describe one case of right and one of left pneumonectomy syndrome as well as one case of post-lobectomy syndrome. We review the literature on the pathophysiology, the clinical, radiological and bronchoscopic characteristics of this rare entity and discuss all available therapeutic alternatives...
May 18, 2017: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/28633250/permeable-nonabsorbable-mesh-for-total-diaphragmatic-replacement-in-extended-pneumonectomy
#19
Luigi Rolli, Giovanni Leuzzi, Paolo Girotti, Leonardo Duranti, Ugo Pastorino
After complex thoracic exenterations, total diaphragmatic resection and reconstruction is challenging. We describe our novel technique for total diaphragmatic replacement with permeable nonabsorbable mesh after extended pneumonectomy.
July 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28622333/acute-40-exchange-transfusion-with-hemoglobin-vesicles-in-a-mouse-pneumonectomy-model
#20
Mitsutomo Kohno, Tatsuhiko Ikeda, Ryo Hashimoto, Yotaro Izumi, Masazumi Watanabe, Hirohisa Horinouchi, Hiromi Sakai, Koichi Kobayashi, Masayuki Iwazaki
OBJECTIVES: Hemoglobin vesicles (HbVs) function as a red blood cell (RBC) substitute and are composed of purified hemoglobin encapsulated in a phospholipid bilayer membrane. The performance of HbVs as a substitute for RBC transfusions was examined in a mouse model of pneumonectomy following acute 40% exchange-transfusion with HbVs. METHODS: Before performing left pneumonectomies, 40% of the blood volume of mice was replaced with a) lactated Ringer's solution (control), b) 5% recombinant human serum albumin (rHSA), c) mouse RBCs shed in rHSA (mRBCs/rHSA), or d) HbV suspended in rHSA (HbV/rHSA)...
2017: PloS One
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