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Pneumonectomy

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https://www.readbyqxmd.com/read/28432576/clinical-benefit-of-neoadjuvant-chemoradiotherapy-for-the-avoidance-of-pneumonectomy-assessment-in-12-consecutive-centrally-located-non-small-cell-lung-cancers
#1
Keizo Misumi, Hiroaki Harada, Norifumi Tsubokawa, Yasuhiro Tsutani, Kotaro Matsumoto, Yoshihiro Miyata, Yoshinori Yamashita, Morihito Okada
BACKGROUND: Considering that pneumonectomy itself is a disease, avoidance of pneumonectomy needs to be deliberated. Herein, we evaluated the role of neoadjuvant chemoradiotherapy for avoidance of pneumonectomy in patients with centrally located locally advanced non-small cell lung cancer. METHODS: Patients who underwent neoadjuvant chemoradiotherapy after being judged to require pneumonectomy by cancer board between 1997 and 2011 were retrospectively evaluated. RESULTS: Twelve patients, including 10 males and 2 females with median age 63...
April 21, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28432436/chemokine-involvement-in-lung-injury-secondary-to-ischaemia-reperfusion
#2
Lisa Rancan, Sergio D Paredes, Luis Huerta, Javier Casanova, Jorge Guzmán, Ignacio Garutti, Federico González-Aragoneses, Carlos Simón, Elena Vara
INTRODUCTION: During transplant surgeries, the lung experiences an ischaemia-reperfusion (I/R)-induced damage identified as a significant cause of morbidity and mortality. However, the mechanisms by which I/R induces leucocyte accumulation and subsequent tissue damage in lung surgeries remain unknown. Therefore, the present study aims to assess the role of monocyte chemotactic protein 1 (MCP-1) and macrophage inflammatory protein 2 (MIP-2) in leucocyte chemotaxis related to lung injury secondary to I/R...
April 21, 2017: Lung
https://www.readbyqxmd.com/read/28431731/pericardial-conduit-for-pulmonary-artery-reconstruction-by-surgical-stapling
#3
Noriyuki Matsutani, Eiichi Kanai, Ryutaro Hanawa, Yusuke Takahashi, Hirofumi Uehara, Hisae Iinuma, Masafumi Kawamura
Pulmonary artery reconstruction in lung cancer surgery is an effective surgical method to avoid pneumonectomy that leads to longer survival times with few adverse effects. The pericardium is often used for the interposition of a prosthetic conduit. A pericardial conduit can be easily and precisely constructed by surgical stapling, which facilitates pulmonary artery reconstruction. In this report, the process and pitfalls of surgical stapling are described.
May 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28431709/successful-single-lung-transplantation-in-a-patient-with-a-lung-destroyed-by-tuberculosis
#4
Hye Ju Yeo, Woo Hyun Cho, Dohyung Kim, Doosoo Jeon, Yun Seong Kim
In most countries, patients with lungs destroyed by tuberculosis (TB) are excluded from lung transplantation (LTx) because of concerns about TB recurrence. LTx may be an effective therapeutic option for patients with chronic respiratory failure, but there are no reports of successful LTx in patients with lungs destroyed by TB. We present the case of successful single LTx in a patient with chronic respiratory failure after pneumonectomy with antituberculous chemotherapy. At the 16-month follow-up, he did not show any evidence of TB recurrence and his respiratory problems and quality of life were improved by LTx...
May 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28422883/transverse-rectus-abdominis-myocutaneous-flap-for-postpneumonectomy-bronchopleural-fistula-a-case-report
#5
Jen-Wu Huang, Yi-Ying Lin, Nai-Yuan Wu, Chien-Ho Tsai
RATIONALE: Numerous types of flap coverage have been reported to prevent or to repair bronchopleural fistulas. Most of the flaps were harvested from chest area. However, these pedicled flaps might not be optimal for the patient who has undergone previous radiotherapy on pulmonary parenchyma because the pedicle artery of the flap might have been injured by irradiation. Therefore, an alternative flap outside of the chest area is necessary. PATIENT CONCERNS: A 61-year-old male was diagnosed of squamous cell carcinoma in right upper lobe lung (cT3N2M0, stage IIIa)...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28413786/surgical-management-of-bronchopulmonary-carcinoids-a-single-center-experience
#6
Ashish Jakhetiya, Pankaj Kumar Garg, Rambha Pandey, Palaniappan Ramanathan, Sunil Kumar, Debojit Nath, Durgatosh Pandey
INTRODUCTION: Bronchopulmonary carcinoids are uncommon tumors with relatively indolent biological behavior but a distinct malignant potential. Surgery is the mainstay of treatment. Our aim was to study preoperative characteristics, surgical approaches, and outcome in patients with bronchopulmonary carcinoid tumors. PATIENTS AND METHODS: This retrospective study was done in the Department of Surgical Oncology of a Tertiary Teaching Hospital of North India. The case records of all the patients who underwent surgical treatment for lung neoplasms and were diagnosed to have bronchopulmonary carcinoids were reviewed...
January 2017: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/28413393/circulating-tumor-cell-count-can-be-a-useful-prognostic-factor-in-lung-resection-via-cardiopulmonary-bypass
#7
Masaki Hashimoto, Yoshitomo Okumura, Fumihiro Tanaka, Kazue Yoneda, Teruhisa Takuwa, Nobuyuki Kondo, Seiki Hasegawa
Tumor resection with cardiopulmonary bypass (CPB) remains controversial in the field of oncology. Here, we present a 57-year-old male patient with locally advanced squamous cell carcinoma. The tumor was located in the left hilum and invaded the left atrium. Complete resection, left pneumonectomy combined with partial left atrium resection, was achieved using CPB. We evaluated the circulating tumor cell (CTC) counts, as a surrogate for micrometastasis, in peripheral blood and the CPB circuit. Both CTC counts were 0, which could indicate local disease without micrometastasis...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28407246/trimodality-therapy-for-pancoast-tumors-t4-is-not-a-contraindication-to-radical-surgery
#8
Ryuichi Waseda, Thomas Klikovits, Mir Alireza Hoda, Konrad Hoetzenecker, Pietro Bertoglio, Karin Dieckmann, Sabine Zöchbauer-Müller, Robert Pirker, Helmut Prosch, Balazs Döme, Walter Klepetko
OBJECTIVE: This study aims to evaluate the impact of T stage and extended surgery on the outcome of patients with Pancoast tumors after induction chemoradiation therapy. METHODS: Forty-six consecutive patients who underwent chemoradiation therapy (platin-based, 45-66 Gy) followed by surgery between 1998 and 2013 were retrospectively reviewed and analyzed. RESULTS: In 28 (61%) patients with T4 tumors, extended procedures (more than rib resection) were performed...
April 13, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28402406/induction-chemotherapy-for-t3n0m0-non-small-cell-lung-cancer-increases-the-rate-of-complete-resection-but-does-not-confer-improved-survival
#9
Kevin L Anderson, Michael S Mulvihill, Babatunde A Yerokun, Paul J Speicher, Thomas A D'Amico, Betty C Tong, Mark F Berry, Matthew G Hartwig
OBJECTIVES: The objective of this study was to evaluate outcomes of induction therapy prior to an operation in patients with cT3 non-small-cell lung cancer (NSCLC). METHODS: Patients diagnosed with cT3N0M0 NSCLC from 2006 to 2011 in the National Cancer Database who were treated with lobectomy or pneumonectomy were stratified by treatment strategy: an operation first versus induction chemotherapy. Propensity scores were developed and matched cohorts were generated...
April 11, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28395387/novel-techniques-and-approaches-to-minimally-invasive-thoracic-surgery
#10
Osita Onugha, Rasheed Ivey, Robert McKenna
Approximately two decades ago, thoracic surgery witnessed the leap from thoracotomy to the first video-assisted thoracic surgery (VATS) lobectomy. Minimally invasive lobectomy and hilar lymphadenectomy is now widely established as a safe and oncological sound technique that is the standard of care for early-stage lung cancer. The move toward less invasive surgery has no doubt driven the innovation of sophisticated instruments and technology to cope with the demanding need of working through a restricted incision...
April 11, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28384875/sclerosing-pneumocytoma-of-the-lung-a-case-report
#11
Vasugi Gramani Arumugam, Leena Dennis Joseph, Periyasamy Thangavel, Rajendiran Swaminathan, Ramya Rathinam Sunderaj
Pulmonary Sclerosing Pneumocytoma (PSP) is a rare tumour of the lung and is always benign. Diagnosis is made incidentally following chest X-ray or chest CT scan performed for other clinical conditions. We report a case of PSP in a seven-year-old girl who got admitted for evaluation of an anterior mediastinal mass. Clinically, thought of teratoma or other germ cell tumour the mass was excised and sent for histopathological examination. Grossly, we received a pneumonectomy specimen measuring 13x11x8 cm with a nodular firm grey white lesion in the medial aspect of lower and middle lobe measuring 7...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28382273/squamous-cell-carcinoma-arising-from-the-pleural-cavity-after-pneumonectomy-for-chronic-empyema
#12
Yeong Jeong Jeon, Sumin Shin, Young Mog Shim
Malignant tumors associated with chronic empyema have been reported in the literature, and a majority of these tumors are lymphomas. Epithelial tumors originating from the post-pneumonectomy space in patients with chronic empyema are extremely rare. Here, we present the cases of 2 patients with squamous cell carcinoma arising from the pleural cavity after pneumonectomy for chronic empyema.
April 2017: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28371288/intensity-modulated-radiation-therapy-after-extra-pleural-pneumonectomy-for-malignant-pleural-mesothelioma-is-feasible-without-fatal-pulmonary-toxicity-and-provides-good-survival
#13
Sameer Jhavar, Jessica Pruszynski, Alan Gowan, Teresa Boyle, Niloyjyoti Deb, Mehul Patel
AIM: To analyze patterns of failure, toxicity, relapse-free survival (RFS), and overall survival (OS) in malignant pleural mesothelioma (MPM) patients treated with intensity-modulated radiation therapy following extrapleural pneumonectomy (EPP). METHODS: We reviewed 18 charts of patients with MPM from 2005 to 2014 who underwent EPP followed by hemithoracic intensity-modulated radiation therapy. Intensity-modulated radiation therapy dose delivery adhered to published lung dose constraints...
March 29, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28369361/long-term-outcome-of-pulmonary-resection-for-nontuberculous-mycobacterial-pulmonary-disease
#14
Takanori Asakura, Nobutaka Hayakawa, Naoki Hasegawa, Ho Namkoong, Ken Takeuchi, Shoji Suzuki, Makoto Ishii, Tomoko Bestuyaku, Yoshiaki Abe, Motofumi Ouchi
BACKGROUND: Pulmonary resection along with multiple antimicrobial therapy has produced favorable outcomes at a few centers. However, little is known regarding the risk factors for long-term survival and microbiological recurrence after pulmonary resection for nontuberculous mycobacterial pulmonary disease (NTMPD). We evaluated the long-term outcomes of pulmonary resection, including microbiological recurrence and survival. METHODS: This retrospective cohort study included 125 patients (median age, 60 years) with NTMPD treated by pulmonary resection at two referral centers between January 1994 and August 2015...
March 25, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28367854/development-of-allograft-cancer-after-lung-transplantation-a-case-report
#15
Esther I Schwarz, Bart Vrugt, Lars C Huber, Christian Murer, Mace M Schuurmans, Ilhan Inci, Christian Benden
INTRODUCTION: In contrast to skin cancer and lymphoproliferative disorders, de-novo lung allograft cancer is seldom reported after lung transplantation. CASE REPORT: A 19-year-old patient with severe pulmonary hypertension listed urgently for lung transplantation underwent successful bilateral lung transplant procedure receiving lungs from a 55-year-old donor with a smoking history of 30 pack years. After 3.5 years of lung transplantation, a locally advanced squamous cell carcinoma in the left lung allograft was diagnosed...
March 29, 2017: Annals of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28366682/indications-for-lung-resection-surgery-and-lung-transplant-in-south-american-children-with-cystic-fibrosis
#16
REVIEW
Fabíola Villac Adde, Sílvia Vidal Campos, Ricardo Henrique de Oliveira Braga Teixeira, Joaquim Carlos Rodrigues
The current available literature evaluating lung resection surgery and lung transplantation in children with cystic fibrosis (CF) was reviewed through a PubMed search and references from selected studies were additionally included. Pulmonary resections, i.e. lobectomy, segmentectomy, and pneumonectomy, are seldom performed in CF. The main indications, in patients with a forced expiratory volume in 1second (FEV1) that is greater than 30% predicted, are localized bronchiectasis/atelectasis, severe hemoptysis, and bronchopleural fistula refractory to medical management...
February 16, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28366460/polytetrafluoroethylene-or-acellular-dermal-matrix-for-diaphragmatic-reconstruction
#17
Juri K Bassuner, David C Rice, Mara B Antonoff, Arlene M Correa, Garrett L Walsh, Ara A Vaporciyan, Naveen Garg, Boris Sepesi, Stephen G Swisher, Wayne L Hofstetter, Jack A Roth, Reza J Mehran
BACKGROUND: We aimed to evaluate the impact of collagen matrix in the reconstruction of the diaphragm. METHODS: We queried the electronic medical record for patients who had resection of the diaphragm and simultaneous pulmonary resection between 1999 and 2016. All reconstructions were performed with either polytetrafluoroethylene or acellular dermal matrix. We evaluated the rate of empyema and herniation in each group. RESULTS: A total of 208 patients met inclusion criteria...
March 30, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28363864/alveolar-septal-patterning-during-compensatory-lung-growth-part-ii-the-effect-of-parenchymal-pressure-gradients
#18
Shimon Haber, Michal Weisbord, Steven J Mentzer, Akira Tsuda
In most mammals, compensatory lung growth occurs after the removal of one lung (pneumonectomy). Although the mechanism of alveolar growth is unknown, the patterning of complex alveolar geometry over organ-sized length scales is a central question in regenerative lung biology. Because shear forces appear capable of signaling the differentiation of important cells involved in neoalveolarization (fibroblasts and myofibroblasts), interstitial fluid mechanics provide a potential mechanism for the patterning of alveolar growth...
March 28, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28359376/living-without-lungs-bilateral-pneumonectomy-and-dual-circulatory-support-a-step-forward-in-the-search-for-a-total-artificial-lung
#19
EDITORIAL
Christian A Bermudez, Maria M Crespo
No abstract text is available yet for this article.
April 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28349384/extended-surgery-for-t4-lung-cancer-a-30-years-experience
#20
P G Dartevelle, D Mitilian, E Fadel
T4 non-small cell lung carcinomas (NSCLC) were deemed unresectable. Advances in surgery have challenged this dogma. We describe technical aspects and result on superior vena cava (SVC), carinal, thoracic inlet tumor surgeries, and resection under cardiopulmonary bypass (CPB). SVC reconstruction requires hemodynamic control to reverse SVC clamping cerebral effects and excellent cephalic venous bed patency. Among 50 SVC resections, including 25 carinal pneumonectomies, post-operative mortality rate was 8%. In the N0-N1 group, 5- and 10-year survival rates were 46...
March 27, 2017: General Thoracic and Cardiovascular Surgery
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