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https://www.readbyqxmd.com/read/28812595/compulsive-like-sufentanil-vapor-self-administration-in-the-rat
#1
Janaina Cm Vendruscolo, Brendan J Tunstall, Stephanie A Carmack, Brooke E Schmeichel, Emily G Lowery-Gionta, Maury Cole, Olivier George, Sophia Vandewater, Michael Taffe, George F Koob, Leandro F Vendruscolo
Opioid misuse is at historically high levels in the United States, with inhalation (ie, smoking, and vaping) being one of the most common routes of consumption. We developed and validated a novel preclinical model of opioid self-administration by inhalation that does not require surgery and reliably produces somatic and motivational signs of dependence. Rats were trained to perform an operant response (nosepoke) to receive 10 s of vaporized sufentanil, a potent opioid, in 2 h daily sessions. Rats readily and concentration-dependently self-administered vaporized sufentanil...
August 16, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28812196/convergent-validation-and-transfer-of-learning-studies-of-a-virtual-reality-based-pattern-cutting-simulator
#2
Arun Nemani, Woojin Ahn, Clairice Cooper, Steven Schwaitzberg, Suvranu De
INTRODUCTION: Research has clearly shown the benefits of surgical simulators to train laparoscopic motor skills required for positive patient outcomes. We have developed the Virtual Basic Laparoscopic Skill Trainer (VBLaST) that simulates tasks from the Fundamentals of Laparoscopic Surgery (FLS) curriculum. This study aims to show convergent validity of the VBLaST pattern cutting module via the CUSUM method to quantify learning curves along with motor skill transfer from simulation environments to ex vivo tissue samples...
August 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28812144/-trends-in-ablation-surgery-what-has-changed-compared-to-2001
#3
C V Fischer, M Kulanga, H Hoerauf
INTRODUCTION: In 2001 a survey among retinal surgeons regarding the treatment of rhegmatogenous retinal detachment either with scleral buckling methods or primary vitrectomy was performed. Due to the technical progress of vitrectomy and observational systems, it seemed appropriate to renew and update this survey supplemented with current aspects. METHODS: In this study 78 vitreoretinal surgeons from German-speaking countries were surveyed via an anonymous online questionnaire on their treatment decisions for defined retinal detachment constellations...
August 15, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28811989/postoperative-kinetics-of-c-reactive-protein-and-erythrocyte-sediment-rate-in-one-two-and-multilevel-posterior-spinal-decompressions-and-instrumentations
#4
Sombat Kunakornsawat, Rachata Tungsiripat, Dechporn Putthiwara, Chaiwat Piyakulkaew, Tinnakorn Pluemvitayaporn, Pritsanai Pruttikul, Piyabuth Kittithamvongs
STUDY DESIGN: Prospective study. OBJECTIVE: To characterize the normal pattern of kinetics of postoperative C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) after decompression, spinal instrumentation, and posterolateral fusion in 1, 2, and more than 2 levels. METHODS: Blood specimens were obtained from patients who underwent posterior decompression, instrumentation with pedicular screws, and posterolateral fusion from June 2009 to January 2011...
August 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28811985/incidence-impact-and-risk-factors-for-30-day-wound-complications-following-elective-adult-spinal-deformity-surgery
#5
Nathan J Lee, John I Shin, Parth Kothari, Jun S Kim, Dante M Leven, Jeremy Steinberger, Javier Z Guzman, Branko Skovrlj, John M Caridi, Samuel K Cho
STUDY DESIGN: Case-control study. OBJECTIVE: To determine the incidence, impact, and risk factors for wound complications within 30 days following elective adult spinal deformity surgery. METHODS: Current Procedural Terminology and International Classification of Diseases, Ninth Edition, diagnosis codes were used to query the database for adults who underwent spinal deformity surgery from 2010 to 2014. Patients were separated into groups of those with and without wound complications...
August 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28811796/visual-outcome-after-phacoemulsification-with-lens-implant-in-diabetic-and-non-diabetic-patients-a-comparative-study
#6
Abdul Rashid Shaikh, Abdul Haleem Mirani, Muhammad Saleh Memon, Muhammad Faisal Fahim
OBJECTIVE: To compare the visual outcomes of phacoemulsification surgery with intraocular lens (IOL) in persons with and without diabetes at end of follow-up. METHODS: This was a comparative, cross sectional, observational study with Non-probability, purposive sampling. After approval from "Research Ethical Committee of Isra Post-graduate Institute of Ophthalmology Karachi, 92 patients with cataract in one eye were selected. Patients were divided into two groups...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28811007/acceleration-of-skin-wound-healing-by-low-dose-indirect-ionizing-radiation-in-male-rats
#7
Nasrollah Jabbari, Gholam Hossein Farjah, Behnam Ghadimi, Hajar Zanjani, Behnam Heshmatian
A recent hypothesis has revealed that low-dose irradiation (LDI) with ionizing radiation might have a promoting effect on fracture healing. The aim of this study was to investigate the influence of direct (electron beam) and indirect (gamma-ray) low-dose ionizing irradiations on the wound healing process in male rats. In 72 male rats, a full-thickness wound was incised. The animals were randomly assigned to three groups, each with 24 rats. The first two groups were named IG-I and IG-II and respectively exposed to electron and gamma-radiations (75 cGy) immediately after the surgical procedure...
August 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/28810991/posterior-cruciate-ligament-injuries-associated-with-military-survival-swim-training
#8
Michael S Crowell, John S Mason, Matthew A Posner, Chad A Haley
OBJECTIVES: Posterior cruciate ligament (PCL) injuries are relatively common injuries associated with athletic activities and high-energy trauma. Posterolateral corner (PLC) injuries frequently accompany injury to the PCL. Diagnosis can be challenging and requires a comprehensive history and physical examination. Patients frequently report vague, nonspecific symptoms and the mechanism of injury is often useful in localizing injured structures. Two of the more common mechanisms for PCL injury include a direct blow to the proximal anterior tibia with the knee flexed, as well as a significant knee hyperextension injury...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28808824/gasless-single-incision-laparoscopic-inguinal-hernia-repair-initial-experience
#9
M W V Ng, K C Ng
PURPOSE: Laparoscopic hernioplasty has been gaining its popularity in the past decade for its rapid recovery. Single-incision surgery, as its possible advancement, has also received more attention. Traditional laparoscopic surgery with carbon dioxide insufflation precluded patients with underlying cardiovascular or pulmonary disease from minimal invasive surgery. We report our early experience with gasless single-incision laparoscopic inguinal hernia repair via totally extraperitoneal (TEP) approach...
August 14, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28808633/comparing-the-effect-of-a-desensitizing-material-and-a-self-etch-adhesive-on-dentin-sensitivity-after-periodontal-surgery-a-randomized-clinical-trial
#10
Hila Hajizadeh, Atefeh Nemati-Karimooy, Sara Majidinia, Amir Moeintaghavi, Marjaneh Ghavamnasiri
OBJECTIVES: This double-blind randomized placebo-controlled clinical trial evaluated the ability of a desensitizing agent and a self-etch adhesive on cervical dentin sensitivity (CDS) after periodontal surgery. MATERIALS AND METHODS: Ninety hypersensitive teeth of 13 subjects were included in the study. After periodontal surgery, the teeth of each posterior sextant treated with one of the following materials: G1: Clearfil S(3) Bond (Kuraray Dental), G2: Gluma Desensitizer (Heraeus Kulzer), and G3: placebo (water)...
August 2017: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/28808605/fatal-cerebral-swelling-immediately-after-cranioplasty-a-case-report
#11
Yuta Kaneshiro, Keiji Murata, Shigeru Yamauchi, Yumiko Urano
BACKGROUND: Cranioplasty is a standard neurosurgical procedure which is performed after decompressive craniotomy. Fatal complications associated with this procedure are not well documented. Here, we report a case of fatal cerebral swelling after cranioplasty and discuss the possible mechanism of this complication. CASE DESCRIPTION: A 64-year-old man was admitted with the diagnosis of cerebral hemorrhage, and emergency surgery for hemorrhage removal and decompressive craniotomy were performed...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28807808/safety-and-efficacy-of-amnion-graft-in-preventing-reformation-of-intra-uterine-adhesions
#12
Xuebing Peng, TinChiu Li, Yuting Zhao, Yan Guo, Enlan Xia
OBJECTIVE: To determine the safety and efficacy of amnion graft in the prevention of recurrence of intrauterine adhesions after hysteroscopic adhesiolysis in women with severe intrauterine adhesions. DESIGN: Retrospective matched cohort study including 120 patients treated during 62 months (Canadian Task Force classification II-2). SETTING: Tertiary referral center. PATIENTS: A total of one hundred and twenty patients who underwent intrauterine adhesiolysis for severe intrauterine adhesion, forty patients in the treatment group, eighty patients in the control group matched for age and adhesion scores...
August 11, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28807031/inflammation-and-pro-resolution-inflammation-after-hepatobiliary-surgery
#13
Juan P Cata, Jose F Velasquez, Maria F Ramirez, Jean-Nicolas Vauthey, Vijaya Gottumukkala, Claudius Conrad, Bradford J Kim, Thomas Aloia
BACKGROUND: The magnitude of the perioperative inflammatory response plays a role in surgical outcomes. However, few studies have explored the mechanisms of the resolution of inflammation in the context of surgery. Here, we described the temporal kinetics of interleukin-6, cortisol, lipoxin A4, and resolvin D in patients who underwent oncologic liver resections. METHODS: All patients gave written informed consent. Demographic and perioperative surgical data were collected, along with blood samples, before surgery and on the mornings of postoperative days 1, 3, and 5...
August 10, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28804692/one-case-with-dexmedetomidine-induced-stuporous-state-in-epileptic-patient-undergoing-abdominal-surgery
#14
Dong-Ji Han, Zhi-Gang He, Zhi-Qiang Zhou, Li Feng, Cheng Liu, Yan Xiang, Hong-Bing Xiang
A 56-year-old epileptic patient underwent right hemicolectomy and cholecystectomy surgery under general endotracheal anesthesia. Anesthesia was maintained with sevoflurane, and sufentanil, rocuronium, and dexmedetomidine infusions. After the operation and confirmation of neuromuscular recovery, the patient woke from anesthesia within 15 min and successfully extubated. After the vital signs of patient were stable, the patient was transported to post anesthesia care unit (PACU). 6 h after the surgery, he fell into a stuporous state for lasting 14 h and EEG showed no epileptiform discharges...
2017: American Journal of Neurodegenerative Disease
https://www.readbyqxmd.com/read/28803177/clusterin-a-new-cerebrospinal-fluid-biomarker-in-severe-subarachnoid-haemorrhage-a-pilot-study
#15
Norbert Wąsik, Bartosz Sokół, Marcin Hołysz, Witold Mańko, Robert Juszkat, Piotr Paweł Jagodziński, Roman Jankowski
BACKGROUND: Inflammation following subarachnoid haemorrhage (SAH) employs numerous mediators with biomarker properties. Preliminary studies indicated that clusterin, a multifunctional chaperon protein, was a potential biomarker in SAH. We aim to clarify the status of clusterin in SAH. METHOD: 47 CSF samples were collected on post-SAH days 0-3, 5-7, and 10-14 from 27 patients with severe SAH. Control CSF was collected from 25 age- and sex- matched healthy patients undergoing spinal anaesthesia for minor surgery...
August 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28803035/bone-tunnel-change-develops-within-two-weeks-of-double-bundle-anterior-cruciate-ligament-reconstruction-using-hamstring-autograft-a-comparison-of-different-postoperative-immobilization-periods-using-computed-tomography
#16
Ryo Shimizu, Nobuo Adachi, Minoru Ishifuro, Atsuo Nakamae, Masakazu Ishikawa, Masataka Deie, Mitsuo Ochi
BACKGROUND: The purpose of this study was to evaluate bone tunnel changes following anterior cruciate ligament (ACL) reconstruction during the early postoperative period using computed tomography (CT), and to understand the impact of postoperative immobilization on these changes. METHODS: Twenty patients who underwent double-bundle ACL reconstruction using hamstring tendon autografts were included. We subcategorized patients into two groups: patients who underwent isolated ACL reconstruction and had three days of knee immobilization (Group A, n=10); and patients with concomitant meniscus injuries who underwent ACL reconstruction and meniscus repair simultaneously (Group B, n=10) had their knees immobilized for two weeks after surgery...
August 9, 2017: Knee
https://www.readbyqxmd.com/read/28802375/post-tonsillectomy-hemorrhagic-outcomes-in-children-with-bleeding-disorders-at-a-single-institution
#17
Priyesh N Patel, Alexandra M Arambula, Allison P Wheeler, Edward B Penn
OBJECTIVE: To report on the post-tonsillectomy bleeding outcomes and factors associated with hemorrhage among children with pre- or post-operatively diagnosed bleeding disorders treated with an institutional protocol. METHODS: Retrospective cohort study of patients with hematologic disorders who underwent tonsillectomy between 2003 and 2016 and were treated with perioperative desmopressin or factor replacement and/or aminocaproic acid. Postoperative outcomes were compared to controls matched for age, sex, and indication for surgery...
September 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28802358/guillotine-vs-classic-dissection-adenotonsillectomy-what-s-the-ideal-technique-for-children-in-tanzania
#18
Desderius C Chussi, Sophie W Poelman, Niels Van Heerbeek
OBJECTIVES: Adenotonsillectomy (ATE) is one of the most performed surgeries in children. Extensive research on which operation technique is the best in terms of minimal pain and complications, operative time and duration of hospital stay is being done mostly in highly resourced developing countries. In developing countries a need for cost effective and time saving operation techniques is essential due to the low-resource setting. This study aims to investigate whether the Guillotine Sluder operation techniques is ideal in a limited resource developing country setting...
September 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28801854/how-do-red-and-infrared-low-level-lasers-affect-folliculogenesis-cycle-in-rat-s-ovary-tissue-in-comparison-with-clomiphene-under-in-vivo-condition
#19
Paria Naseri, Alireza Alihemmati, Seyed Hossein Rasta
Folliculogenesis is a cycle that produces the majority of oocyte. Any disruption to this cycle leads to ovulation diseases, like polycystic ovarian syndrome (PCOS). Treatments include drugs and surgery; lasers have also been used complementarily. Meanwhile, still there is no definite treatment for PCOS. This study investigated the photo-bio stimulation effect of near-infrared and red low-level laser on producing follicles and compared the result with result of using common drug, clomiphene. Therefore, the aim of this study was to propose the use of lasers autonomously treatment...
August 11, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28801718/stentless-endoscopic-repair-of-congenital-choanal-atresia-is-it-enough-for-maintaining-choanal-patency
#20
Emel Çadallı Tatar, Bülent Öcal, Esra Doğan, Ömer Bayır, Cem Saka, Ali Özdek, Mehmet Hakan Korkmaz
The aim of choanal atresia (CA) surgery is to achieve bilateral nasal patency. Among the different methods of CA repair, the endoscopic transnasal approach has gained recent popularity with the advent of endoscopic instruments and techniques. This article describes our experience regarding CA repair that was done either using or not using a stent in different periods of time in our department. Between February 2006 and February 2016, a total of 29 patients aged 2 days-53 years underwent endoscopic transnasal CA repair...
August 11, 2017: European Archives of Oto-rhino-laryngology
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