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https://www.readbyqxmd.com/read/29475140/the-prognostic-relevance-of-sentinel-lymph-node-metastases-assessed-by-phgr1-mrna-quantification-in-stage-i-to-iii-colon-cancer
#1
Satu Oltedal, Hartwig Kørner, Ole Gunnar Aasprong, Israr Hussain, Kjersti Tjensvoll, Rune Smaaland, Jon Arne Søreide, Kjetil Søreide, Ragnhild A Lothe, Reino Heikkilä, Bjørnar Gilje, Oddmund Nordgård
BACKGROUND: Regional lymph node (LN) metastasis is a strong and well-established prognostic factor in colon cancer, and recent data suggest a prognostic value of detecting micrometastases and isolated tumor cells in regional LNs. The aim of the study was to investigate the clinical relevance of detecting sentinel lymph node (SLN) metastases in colon cancer patients by measuring the novel metastasis marker PHGR1 mRNA. METHODS: Using quantitative reverse-transcription polymerase chain reaction, we measured PHGR1 mRNA levels in SLNs and primary tumors from 206 patients surgically treated for stage I to III colon cancer and 52 normal LNs from patients undergoing surgery for benign colon diseases...
February 20, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29473957/comparison-of-two-novel-staging-systems-with-the-tnm-system-in-predicting-stage-iii-colon-cancer-survival
#2
Richard Walker, Trevor Wood, Emily LeSouder, Michelle Cleghorn, Manjula Maganti, Andrea MacNeill, Fayez A Quereshy
BACKGROUND AND OBJECTIVES: Adaptations of the TNM staging system that incorporate the Lymph Node Ratio (LNR) have been proposed for stage III colon cancer. This study compared the concordance of two novel staging systems and the TNM system with observed survival outcomes in stage III patients. METHODS: A review of patients who underwent surgery for stage III colon cancer between January 2002 and April 2015 at a tertiary care centre was performed. The Kaplan-Meier method was used to estimate the 5-year overall (OS) and disease free survival (DFS) rates, and the concordance probability was calculated to evaluate the discriminatory power of the staging systems...
February 23, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29473452/a-new-surgical-device-for-anterograde-intraoperative-rectal-washout
#3
Fabio Rondelli, Roberto Santinelli, Paolo Stella, Walter Bugiantella, Graziano Ceccarelli, Ruben Carlo Balzarotti, Michele De Rosa, Nicola Avenia
BACKGROUND: Colorectal cancer is the fourth most diffuse cause of death in the world and local recurrence is associated with a reduced long-term life expectancy, with a reduced quality of life. Rectal washout at the anastomosis site leads to a statistically significant reduction of local recurrences. METHODS: We developed the idea of a new laparoscopic stapler with an integrated washout system that could decontaminate the rectal stump before resection, without the need to enlarge the standard surgical incision or even to distort the incision site, closing the rectal stump just below the inferior part of the cancer, and then proceeding with the resection and stapling of the distal part of the tumor...
February 1, 2018: Surgical Innovation
https://www.readbyqxmd.com/read/29470729/retromesenteric-course-of-the-middle-colic-artery-challenges-and-pitfalls-in-d3-right-colectomy-for-cancer
#4
Bojan V Stimec, Bjarte T Andersen, Stefan R Benz, Jean H D Fasel, Knut M Augestad, Dejan Ignjatovic
BACKGROUND: The middle colic artery (MCA) is of crucial importance in abdominal surgery, for laparoscopic or open right and transverse colectomies. Against this background, a high number of reports concerning anatomical variations of the MCA have been published intended to contribute to the improvement of operative techniques for the treatment of colon cancer. Despite this extensive literature, briefly reviewed in the present paper, a course of the MCA posterior to the superior mesenteric vein, called a retromesenteric trajectory, has been related to only once, to the best of our knowledge...
February 22, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29470651/prediction-of-surgical-site-infection-in-spine-surgery-from-tests-of-nasal-mrsa-colonization-and-drain-tip-culture
#5
Kazuyoshi Kobayashi, Kei Ando, Kenyu Ito, Mikito Tsushima, Masayoshi Morozumi, Satoshi Tanaka, Masaaki Machino, Kyotaro Ota, Naoki Ishiguro, Shiro Imagama
PURPOSE: MRSA is an organism that is a possible risk factor for postoperative SSI. The purpose of the study was to examine relationships among surgical site infection (SSI) after spinal surgery, nasal methicillin-resistant staphylococcus aureus (MRSA) colonization, and wound drain culture results. METHODS: The subjects were 132 patients who underwent spinal instrumentation surgery. A preoperative nasal swab was used to check for the presence of MRSA colonization, and a wound drain tip culture was performed for detection of SSI...
February 22, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29470625/fluoroscopy-guided-trans-anal-decompression-tube-placement-in-the-treatment-of-acute-colonic-pseudo-obstruction-a-single-center-experience
#6
Lili Gu, Bo Yang, Xuelei Zhang, Chao Ding, Hongliang Tian, Weiming Zhu, Jieshou Li, Ning Li
PURPOSE: Acute colonic pseudo-obstruction (ACPO or Ogilvie's syndrome) is a rare but often fatal disease; timely colonic decompression may be essential for successful treatment. This study describes a technique of placing a trans-anal tube via fluoroscopy-guiding and investigates the effect of colon decompression on ACPO. METHODS: Patients undergoing colonic decompression via fluoroscopy-guided trans-anal tube placement from April 2015 to May 2017 were included...
February 22, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29468435/additional-lymph-node-dissection-for-primary-colorectal-cancer-invading-another-colon-region
#7
Ryuma Tokunaga, Yasuo Sakamoto, Shigeki Nakagawa, Yuji Miyamoto, Naoya Yoshida, Hideo Baba
PURPOSE: Surgery remains the curative treatment of choice for colorectal cancer (CRC). However, to our knowledge, no report has addressed the usefulness of additional regional lymph node dissection for primary CRC that has invaded another colon region. METHODS: We reviewed the clinicopathological characteristics and outcomes of eight patients who underwent surgery between March, 2005 and August, 2014, for CRC that invaded another region of the colon. RESULTS: Five patients underwent additional regional lymph node dissection in the area of the invaded colon and one patient had lymph node metastasis in the region...
February 21, 2018: Surgery Today
https://www.readbyqxmd.com/read/29468133/palliative-surgery-for-krukenberg-tumors-12-year-experience-and-review-of-the-literature
#8
Isaac Seow-En, Gwen Hwarng, Grace Hwei Ching Tan, Leonard Ming Li Ho, Melissa Ching Ching Teo
AIM: To determine the clinical characteristics of patients undergoing palliative surgery for Krukenberg tumors, including disease presentation, outcomes, and prognostic factors. METHODS: This was a retrospective clinical study of all patients who underwent palliative surgery for Krukenberg tumors between January 2004 and December 2015. Patient information was obtained from inpatient and outpatient case notes as well as the hospital electronic records. Patients who underwent potentially curative resection, and patients with Krukenberg tumors who did not undergo surgery were also excluded from the study...
February 10, 2018: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29468061/plasma-interleukin-8-levels-are-persistently-elevated-for-1-month-after-minimally-invasive-colorectal-resection-for-colorectal-cancer
#9
H M C Shantha Kumara, Elli Sutton, Geoffrey A Bellini, Xiaohong Yan, Vesna Cekic Rn, Nipa Dilip Gandhi, Richard L Whelan
Minimally invasive colorectal resection (MICR) for colorectal cancer (CRC) is associated with elevated levels of seven proangiogenic proteins that persist for 2-4 weeks after surgery. The proangiogenic plasma may promote tumor growth postoperatively in patients with residual cancer. To the best of our knowledge, the impact of surgery on interleukin 8 (IL-8) levels is unknown. The aim of the present study was to evaluate plasma IL-8 levels after MICR for CRC. Patients with CRC enrolled in an institutional review board-approved plasma/data bank who underwent MICR were eligible...
March 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29466953/the-association-between-community-associated-staphylococcus-aureus-colonization-and-disease-a-meta-analysis
#10
Marina W Kim, Ben K Greenfield, Robert E Snyder, Craig M Steinmaus, Lee W Riley
BACKGROUND: Colonization with Staphylococcus aureus is a well-defined risk factor for disease in hospitals, which can range from minor skin infections to severe, systemic diseases. However, the generalizability of this finding has not been thoroughly investigated outside of the hospital environment. We aimed to assess the role of S. aureus colonization as a risk factor for disease in the community. METHODS: We performed a meta-analysis of observational studies and searched PubMed for articles published between December 1979 and May 23, 2016...
February 21, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29463229/metastatic-cardiac-tumors-from-clinical-presentation-through-diagnosis-to-treatment
#11
Ivana Burazor, Sarit Aviel-Ronen, Massimo Imazio, Orly Goitein, Marina Perelman, Natalia Shelestovich, Ninoslav Radovanovic, Vladimir Kanjuh, Iris Barshack, Yehuda Adler
BACKGROUND: To evaluate the prevalence of metastatic tumors involving the myocardium and study their presentation in order to increase awareness to their existence. METHODS: Pathological reports from Sheba Medical Center (Israel, January 1, 2010 through December 31, 2015) and medical records from The Institute for Cardiovascular Diseases of Vojvodina, Sremska Kamenica (Serbia, 23 years period) were screened for cases of metastatic cardiac tumors. Medical, radiological and pathological data of identified cases was retrieved and reviewed...
February 20, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29462390/segmental-resection-versus-total-proctocolectomy-for-crohn-s-colitis-what-is-the-best-operation-in-the-setting-of-medically-refractory-disease-or-dysplasia
#12
Amy L Lightner
Crohn's disease (CD) may affect any part of the gastrointestinal tract. When isolated to the colon, and patients become medically refractory, there are several surgical options - segmental resection, subtotal colectomy with ileorectal anastomosis, or a total proctocolectomy and end ileostomy. Unfortunately, surgery does not cure CD, and, regardless of the extent of bowel removed, recurrence may be seen in the small bowel. This may lead to need for further immunosuppression or surgery. Therefore, when appropriate, a segmental colectomy or subtotal colectomy may prevent a permanent ostomy required with a total proctocolectomy...
February 15, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29462209/modulation-of-the-colon-cancer-cell-phenotype-by-pro-inflammatory-macrophages-a-preclinical-model-of-surgery-associated-inflammation-and-tumor-recurrence
#13
María Marcuello, Xavier Mayol, Eloísa Felipe-Fumero, Jaume Costa, Laia López-Hierro, Silvia Salvans, Sandra Alonso, Marta Pascual, Luís Grande, Miguel Pera
Peritoneal infection after colorectal cancer surgery is associated with a higher rate of tumor relapse. We have recently proposed that soluble inflammatory factors released in response to a postoperative infection enhance tumor progression features in residual tumor cells. In an effort to set up models to study the mechanisms of residual tumor cell activation during surgery-associated inflammation, we have analyzed the phenotypic response of colon cancer cell lines to the paracrine effects of THP-1 and U937 differentiated human macrophages, which release an inflammatory medium characteristic of an innate immune response...
2018: PloS One
https://www.readbyqxmd.com/read/29460883/-efficacy-of-video-assisted-procedures-in-advanced-age-patients-with-colorectal-cancer
#14
Z B Khalilov, A Yu Kalinichenko, R Kh Azimov, I S Panteleeva, M A Chinikov, F S Kurbanov
AIM: To assess advisability of video-assisted surgery in advanced age patients with colorectal cancer. MATERIAL AND METHODS: The study involved 44 patients with large intestine tumors. There were 30 patients with colon cancer aged 78.0±1.1 years and 14 patients with rectal neoplasms aged 75.0±1.8 years. All of them underwent elective video-assisted resections without conversion of the approach. RESULTS: Good and satisfactory results were achieved in 95...
2018: Khirurgiia
https://www.readbyqxmd.com/read/29460882/-results-of-video-assisted-technologies-in-colorectal-surgery
#15
Yu L Shevchenko, O E Karpov, P S Vetshev, A V Maksimenkov, I V Stepanyuk, Yu M Stoyko, A L Levchuk, V A Nazarov, D A Kolozyan
AIM: To analyze immediate outcomes of 286 laparoscopic and robot-assisted interventions on the colon and rectum. MATERIAL AND METHODS: There were 256 (89.51%) laparoscopic and 30 (10.49%) robot-assisted procedures. 233 (81.46%) operations were performed for rectum and colon cancer. Postoperative complications after colon cancer surgery were revealed in 11.11%, including anastomosis failure in 2.08% of cases. Postoperative complications after rectal cancer surgery occurred in 32...
2018: Khirurgiia
https://www.readbyqxmd.com/read/29459798/-localization-and-size-of-colon-adenomas-as-factors-related-to-high-gradedysplasia
#16
Carlo Arévalo, Natalia Chunga, Steven Alarcón, Omar Rodríguez, Fernando Arévalo, Pedro Montes, Eduardo Monge
OBJECTIVE: To determine whether localization and size are related to the presence of high-grade dysplasia of colon adenomas in patients of a Peruvian hospital. MATERIALS AND METHODS: This is a descriptive transversal study. We checked colonoscopyreports of 2014-2015 years of Hospital Daniel Alcides Carrion, we included the polyps found in patients older than 18 years old, and excluded reports from patients with colorectal cancer, an antecedent of oncological surgery, inflammatory bowel disease and polyposis (6 or more)...
October 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/29459565/-diagnosis-of-duplication-of-the-sigmoid-colon-prior-to-surgery-a-case-study
#17
Kumiko Nakamura, Akio Tamura, Tomoaki Kono, Tadayuki Oshima, Hirokazu Fukui, Seiichi Hirota, Kiyoshi Tsukamoto, Naohiro Tomita, Jiro Watari, Hiroto Miwa
A 16-year-old woman identified with colonic distention using chest X-rays visited our hospital. Although abdominal computed tomography (CT), colonoscopy, and barium enema study indicated suspected duplication of the sigmoid colon, the exact portion of communication between the normal colon and the duplicated colon could not be determined. The patient was released, but followed up due to the lack of symptoms. After 7 months, she was urgently re-hospitalized due to the complaint of abdominal pain. Her abdominal CT revealed the wall thickness and distention of the duplication as well as voluminous stool containing barium...
2018: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/29459018/prognostic-significance-of-18-f-fdg-pet-ct-in-patients-with-colorectal-cancer-liver-metastases-after-hepatectomy
#18
Jae-Ryong Shim, Seung Duk Lee, Sung-Sik Han, Sang Jae Lee, Dong Eun Lee, Seok-Ki Kim, Seong Hoon Kim, Sang Jae Park, Jae-Hwan Oh
INTRODUCTION: Colorectal cancer liver metastasis (CRLM) can be cured with surgery. To improve survival, optimal selection of CRLM patients should be done cautiously, which may be facilitated by preoperative [F-18] fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT). METHODS: A total of 245 patients with CRLM between February 2007 and January 2015 were retrospectively studied. All clinical variables, pathological data, and various PET/CT parameters were correlated with disease-free survival (DFS) and overall survival (OS)...
February 6, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29459013/the-family-coriobacteriaceae-is-a-potential-contributor-to-the-beneficial-effects-of-roux-en-y-gastric-bypass-on-type-2-diabetes
#19
Haijun Liu, Hong Zhang, Xiao Wang, Xuemei Yu, Cheng Hu, Xueli Zhang
BACKGROUND: Changes in gut microbiota induced by bariatric surgery have been associated with metabolic benefits. OBJECTIVES: Our aim was to identify specific gut microbiota that may contribute to the improvement of type 2 diabetes (T2D) after Roux-en-Y gastric bypass (RYGB). SETTING: Laboratories of Shanghai Diabetes Institute and Shanghai Sixth People's Hospital. METHODS: Diabetic rats induced via a high-fat diet and low-dose streptozotocin administration were randomized to RYGB or sham surgery, and stool samples were collected at baseline and at postoperative week 8...
January 17, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29458970/higher-robotic-colorectal-surgery-volume-improves-outcomes
#20
A Bastawrous, C Baer, L Rashidi, C Neighorn
In this study we sought to assess the effect of surgeon volume on outcomes of robotic colorectal operations performed by surgeons with low or high volume across a large health system. We performed a retrospective review of colon or rectal resections performed between January 1, 2013 and January 1, 2017 within the Providence Health System Hospitals. Procedures were separated into those performed by surgeons with high volume (30 or more robotic cases per year) vs. low volume. A total of 8 high volume and 41 low volume robotic surgeons were included in the study...
January 31, 2018: American Journal of Surgery
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