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https://www.readbyqxmd.com/read/26459229/over-ten-thousand-cases-and-counting-acidbase-org-is-serving-the-critical-care-community
#1
EDITORIAL
Paul W G Elbers, Niels Van Regenmortel, Rainer Gatz
Acidbase.org has been serving the critical care community for over a decade. The backbone of this online resource consists of Peter Stewart's original text "How to understand Acid-Base" which is freely available to everyone. In addition, Stewart's Textbook of Acid Base, which puts the theory in today's clinical context is available for purchase from the website. However, many intensivists use acidbase.org on a daily basis for its educational content and in particular for its analysis module. This review provides an overview of the history of the website, a tutorial and descriptive statistics of over 10,000 queries submitted to the analysis module...
2015: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/24557800/sodium-bicarbonate-treatment-prevents-gastric-emptying-delay-caused-by-acute-exercise-in-awake-rats
#2
Moisés T B Silva, Raimundo C Palheta-Junior, Daniel F Sousa, Patrícia A Fonseca-Magalhães, Willy Okoba, Caio P S Campos, Ricardo B Oliveira, Pedro J C Magalhães, Armenio A Santos
Physical exercise, mainly after vigorous activity, may induce gastrointestinal dysmotility whose mechanisms are still unknown. We hypothesized that physical exercise and ensuing lactate-related acidemia alter gastrointestinal motor behavior. In the present study, we evaluated the effects of short-term exercise on gastric emptying rate in awake rats subjected to 15-min swimming sessions against a load equivalent to 5% of their body weight. After 0, 10, or 20 min of exercise testing, the rats were gavage fed with 1...
May 1, 2014: Journal of Applied Physiology
https://www.readbyqxmd.com/read/23652168/evaluation-of-acid-base-status-in-brain-dead-donors-and-the-impact-of-metabolic-acidosis-on-organ-retrieval
#3
J H Lee, M S Kim, S Na, S O Koh, J Sim, Y S Choi
Background: Pathophysiologic changes after brain death can lead to acid-base disturbances. The primary aim of this study was to clarify the acid-base state and its source in brain dead donors using Stewart's approach. Additionally, we investigated whether the presence of metabolic acidosis affected the number of organs retrieved from donors. Methods: A retrospective review of electronic medical records was performed for brain dead donors who had undergone organ harvesting during the past 5 years in a tertiary medical center...
May 6, 2013: Minerva Anestesiologica
https://www.readbyqxmd.com/read/22432752/qt-intervals-in-patients-receiving-a-renal-transplant
#4
Ali Monfared, Zahra Atrkar Roshan, Arsalan Salari, Farshad Asadi, Mohammadkazem Lebadi, Masoud Khosravi, Sepiedeh Besharati
OBJECTIVES: Cardiovascular disease is the most-common cause of mortality in patients with end-stage renal disease and renal transplant. Prolongation of QTc(max) and QTc dispersion are risk factors of cardiac arrhythmias and mortality. This study compares the changes of QT parameters before hemodialysis, after hemodialysis, and after renal transplant. MATERIALS AND METHODS: Patient candidates for renal transplant were selected. Mean serum electrolyte and 12-lead electrocardiogram were recorded (1) immediately, (2) before and, (3) after the last dialysis session before renal transplant, (4) and 2 weeks after a kidney transplant in 34 patients with normal graft function (plasma Cr ≤ 176...
April 2012: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/22360552/nhe-1-a-promising-target-for-novel-anti-cancer-therapeutics
#5
REVIEW
Ser Yue Loo, Michelle Ker Xing Chang, Charis Sui Huay Chua, Alan Prem Kumar, Shazib Pervaiz, Marie Veronique Clement
Among the many factors involved in the maintenance of homeostatic growth is the tight regulation of cellular pH. Intracellular pH of normal cells is maintained within a physiological range thanks to the activity of a number of pH regulators that respond to the acidbase shifts associated with normal cellular metabolic processes. Interestingly, there is a preponderance of evidence that dysregulation of intracellular pH is associated with processes that favor cell transformation such as cell cycle progression, enhanced proliferation, insensitivity to growth inhibitory stimuli, resistance to apoptosis, genomic instability and angiogenesis...
2012: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/21428880/recent-advances-in-studies-on-hydroxamates-as-matrix-metalloproteinase-inhibitors-a-review
#6
REVIEW
R K Yadav, S P Gupta, P K Sharma, V M Patil
Matrix metalloproteinases (MMPs) are a large family of calcium-dependent zinc- containing endopeptidases, which are responsible for the tissue remodeling and degradation of the extracellular matrix (ECM), including collagens, elastins, gelatin, matrix glycoproteins, and proteoglycan. The inappropriate expression of these MMPs constitutes part of the pathogenic mechanism in several diseases, therefore they are subject to inhibition. They can be inhibited by endogenous proteinase inhibitors such as 2-macroglobulin or by the family of tissue inhibitors of metalloproteinases (TIMPs), which are glycoproteins of molecular weight 21-30 kDa, consisting of 184-194 amino acid residues...
2011: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/20941169/laser-threshold-calculations-for-lasing-of-acidbase-species-in-proton-transfer-media
#7
R Weigand, J M Guerra
An estimate of laser thresholds for both the acid and the base species of dyes undergoing proton-transfer reactions is given. It is seen how the excited-state kinetic constants and proton concentration affect the laser threshold of each species. Calculations of laser threshold for simultaneous lasing of both species are also carried out. The latter is applied to the simultaneous lasing of neutral and acid forms of the 4-Amino-1,7-dimethylpyrido[2,3-c]-1,2,6-thiadiazine 2,2-dioxide in acetonitrile and corroborates the experimental results...
September 20, 1994: Applied Optics
https://www.readbyqxmd.com/read/19565024/the-stewart-approach-one-clinician-s-perspective
#8
T John Morgan
Peter Stewart added controversy to an already troubled subject when he entered the clinical acid-base arena. His approach puts water dissociation at the centre of the acid-base status of body fluids. It is based on six simultaneous equations, incorporating the Laws of Mass Action, Mass Conservation, and Electrical Neutrality. Together with Gibbs-Donnan equilibria, these equations explain the diagnostically important PaCO(2)/pH relationship, and improve understanding of the physiologic basis of traditional acid-base approaches...
May 2009: Clinical Biochemist. Reviews
https://www.readbyqxmd.com/read/18432583/acid-base-balance-in-combined-severe-hepatic-and-renal-failure-a-quantitative-analysis
#9
COMPARATIVE STUDY
T Naka, R Bellomo, H Morimatsu, J Rocktaschel, L Wan, P Gow, P Angus
BACKGROUND: Severe hepatic failure (SHF) commonly leads to major changes in acidbase balance status. However, the direct effects of liver failure per se on acid base balance are poorly understood because this condition is usually associated with acute renal failure (ARF). AIM: To assess the effect of SHF on acid-base balance. DESIGN: Retrospective laboratory investigation. SUBJECTS: Thirty-seven critically ill patients with SHF complicated by ARF, and 42 patients with severe ARF without liver failure prior to renal replacement therapy...
April 2008: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/18373316/the-acid-base-effect-of-changing-citrate-solution-for-regional-anticoagulation-during-continuous-veno-venous-hemofiltration
#10
M Egi, T Naka, R Bellomo, C C Langenberg, W Li, N Fealy, I Baldwin
PURPOSE: To compare the acid-base balance effects of two different citrate doses for regional citrate anticoagulant (RCA) for continuous veno-venous hemofiltration (CVVH). METHODS: We used a commercial citrate fluid (citrate concentration: 11 mmol/L) from July 2003 to July 2004 (period A) in 22 patients; then changed to a new citrate fluid (citrate concentration: 14 mmol/L) from July 2004 to Feb 2005 (Period B) in 21 patients. Replacement fluid rate was fixed at 2,000 ml/h...
March 2008: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/18286449/potential-adverse-effects-of-replacing-high-volume-hemofiltration-exchanges-on-electrolyte-balance-and-acid-base-status-using-the-current-commercially-available-replacement-solutions-in-patients-with-acute-renal-failure
#11
EDITORIAL
A Davenport
The original substitution and/or dialysates used for continuous hemofiltration and/or dialysis were either based on peritoneal dialysis fluids, or peritoneal dialysates themselves. Although these fluids have been refined over the years, by changing the anionic base from acetate or racemic d+ l-lactate, to bicarbonate or l-lactate, the fluids remain designed for low volume hourly exchanges. Even at relatively low volume exchanges, the composition of these fluids can affect systemic acidbase balance. Those fluids which contain a higher concentration of lactate with a corresponding lower chloride, predispose to a hypochloremic alkalosis, whereas those with a lower concentration of lactate with a corresponding higher chloride potentially lead to a hyperchloremic acidosis...
January 2008: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/17370054/-meeting-point-stewart-buffer-bases-base-excess-and-strong-ions
#12
REVIEW
W Lang
OBJECTIVE: Development of a two-buffer model which simulates the acid-base properties of blood and allows comparison of the different acidbase concepts according to Stewart and to Siggaard-Andersen. METHODS: The two-buffer model consisted of different aqueous solutions of bicarbonate/CO(2) (pCO(2), sCO(2), pK(1)), HEPES buffer (A(tot), pK(a)) and electrolytes. These were used to calculate the pH from the independent variables according to Stewart - strong ion difference (SID), pCO(2) and total concentration of the weak acids (A(tot)) - from which all other dependent variables (cHCO(3)(-), cA(-), BB, BE) were obtained and compared with the measured values...
April 2007: Der Anaesthesist
https://www.readbyqxmd.com/read/15300171/stimulation-of-intestinal-glutamine-absorption-in-chronic-metabolic-acidosis
#13
Ming Pan, QingHe Meng, Haroon A Choudry, Anne M Karinch, ChengMao Lin, Wiley W Souba
BACKGROUND: Amino acid glutamine plays a central role in inter-organ nitrogen transfer in acidosis, a compensatory mechanism that is essential in maintaining acidbase balance. Intestinal glutamine absorption is a key exogenous glutamine source in maintaining glutamine homeostasis. The purpose of this in vivo study was to investigate the regulation of intestinal glutamine absorption during chronic metabolic acidosis. METHODS: Metabolic acidosis in adult male Sprague-Dawley rats was induced by adding 1...
August 2004: Surgery
https://www.readbyqxmd.com/read/14485095/blood-lactate-levels-and-some-blood-acidbase-changes-in-respiratory-failure-and-their-significance-in-oxygen-induced-respiratory-depression
#14
R W PENMAN
No abstract text is available yet for this article.
August 1962: Clinical Science (1933-1973)
https://www.readbyqxmd.com/read/14437266/the-renal-regulation-of-acidbase-balance-a-summary-of-current-views
#15
A S RELMAN, W B SCHWARTZ
No abstract text is available yet for this article.
May 1960: Journal of the Oklahoma State Medical Association
https://www.readbyqxmd.com/read/14376586/renal-regulation-of-acidbase-balance-in-the-chicken
#16
R A WOLBACH
No abstract text is available yet for this article.
April 1955: American Journal of Physiology
https://www.readbyqxmd.com/read/14021792/metabolic-responses-to-injury-ii-acidbase-balance
#17
G H CLOWES
No abstract text is available yet for this article.
March 1963: Journal of Trauma
https://www.readbyqxmd.com/read/13956607/-clinical-significance-of-the-measurement-of-the-blood-ph-and-gases-for-the-detection-of-disorders-of-acidbase-equilibrium-of-metabolic-or-respiratory-origin
#18
https://www.readbyqxmd.com/read/13945299/cerebrospinal-fluid-acidbase-balance-during-a-changing-ventilatory-state-in-man
#19
V J FISHER, L C CHRISTIANSON
No abstract text is available yet for this article.
July 1963: Journal of Applied Physiology
https://www.readbyqxmd.com/read/13872328/a-comparison-of-certain-acidbase-characteristics-of-arterial-blood-jugular-venous-blood-and-cerebrospinal-fluid-in-man-and-the-effect-on-them-of-some-acute-and-chronic-acid-base-disturbances
#20
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