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https://www.readbyqxmd.com/read/29785395/the-relationship-between-nafld-and-sarcopenia-in-elderly-patients
#1
Yu Zhai, Qian Xiao, Jing Miao
Aim: Previous studies have shown that individuals with low muscle mass exhibit an increased risk of nonalcoholic fatty liver disease (NAFLD). In this study, we investigated the association between NAFLD and sarcopenia in elderly patients. Methods: We classified the participants into sarcopenia/nonsarcopenia groups based on dual-energy X-ray absorptiometry (DXA), muscle strength (grip strength), or/and physical performance (6 m usual gait speed). We diagnosed NAFLD by ultrasonography combined with the history of alcohol intake...
2018: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29785309/colopancreatic-fistula-an-uncommon-complication-of-recurrent-acute-pancreatitis
#2
Mouhanna Abu Ghanimeh, Omar Abughanimeh, Khalil Abuamr, Osama Yousef, Esmat Sadeddin
Colonic complications, including colopancreatic fistulas (CPFs), are uncommon after acute and chronic pancreatitis. However, they have been reported and are serious. CPFs are less likely to close spontaneously and are associated with a higher risk of complications. Therefore, more definitive treatment is required that includes surgical and endoscopic options. We present a case of a 62-year-old male patient with a history of heavy alcohol intake and recurrent acute pancreatitis who presented with a 6-month history of watery diarrhea and abdominal pain...
2018: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/29782302/reasons-for-not-using-condoms-among-heterosexual-men-in-belgrade-serbia
#3
Milan Bjekić, Sandra Sipetić-Grujičić, Hristina Vlajinac, Aleksandra Nikolić
Dear Editor, Proper and consistent use of male condoms can be a highly effective method of preventing the transmission of sexually transmitted infections (STIs) and HIV (1), but this method relies on men's willingness and ability to use condoms. In the United States of America, about 20% overall and less than 50% of adults with multiple partners used a condom at last intercourse (2). In Serbia in 2013 (3), 50.0% of women and 62.5% of men aged 15-49 who had more than one partner in the past year used a condom during their last intercourse...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29781380/finally-a-regimen-to-extend-human-life-expectancy
#4
James Larrick, Andrew R Mendelsohn
The US has the most expensive healthcare system worldwide. Yet measures of healthspan and life expectancy are well below the major industrialized nations. With the US population aged 65 and older projected to double by mid-century a healthcare crisis is looming. Within this context huge interest and investment has emerged in technologies and drugs to address aging with an expected benefit to healthspan. The thesis being that such basic interventions will reduce morbidity caused by many chronic diseases where biological age itself is the major risk factor...
May 21, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29778070/high-intensity-binge-drinking-is-associated-with-alterations-in-spontaneous-neural-oscillations-in-young-adults
#5
Rifqi O Affan, Siyuan Huang, Stephen M Cruz, Lee A Holcomb, Edward Nguyen, Ksenija Marinkovic
Heavy episodic alcohol consumption (also termed binge drinking) contributes to a wide range of health and cognitive deficits, but the associated brain-based indices are poorly understood. The current study used electroencephalography (EEG) to examine spontaneous neural oscillations in young adults as a function of quantity, frequency, and the pattern of their alcohol consumption. Sixty-one young adults (23.4 ± 3.4 years of age) were assigned to binge drinking (BD) and light drinking (LD) groups that were equated on gender, race/ethnic identity, age, educational background, and family history of alcoholism...
January 8, 2018: Alcohol
https://www.readbyqxmd.com/read/29778010/exposure-to-cannabinoid-agonist-win-55-212-2-during-early-adolescence-increases-alcohol-preference-and-anxiety-in-cd1-mice
#6
Jimena Laura Frontera, Victoria María Gonzalez Pini, Fernando Luis Messore, Alicia Brusco
The endocannabinoid (eCB) system is involved in the modulation of the reward system and participates in the reinforcing effects of different drugs of abuse, including alcohol. The most abundant receptor of the eCB system in the central nervous system is the CB1 receptor (CB1R), which is predominantly expressed in areas involved in drug addiction, such as the nucleus accumbens, the ventral tegmental area, the substantia nigra and the raphe nucleus. CB1R is expressed in early stages during development, and reaches maximum levels during early adolescence...
May 16, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29776774/association-of-disrupted-circadian-rhythmicity-with-mood-disorders-subjective-wellbeing-and-cognitive-function-a-cross-sectional-study-of-91-105-participants-from-the-uk-biobank
#7
Laura M Lyall, Cathy A Wyse, Nicholas Graham, Amy Ferguson, Donald M Lyall, Breda Cullen, Carlos A Celis Morales, Stephany M Biello, Daniel Mackay, Joey Ward, Rona J Strawbridge, Jason M R Gill, Mark E S Bailey, Jill P Pell, Daniel J Smith
BACKGROUND: Disruption of sleep and circadian rhythmicity is a core feature of mood disorders and might be associated with increased susceptibility to such disorders. Previous studies in this area have used subjective reports of activity and sleep patterns, but the availability of accelerometer-based data from UK Biobank participants permits the derivation and analysis of new, objectively ascertained circadian rhythmicity parameters. We examined associations between objectively assessed circadian rhythmicity and mental health and wellbeing phenotypes, including lifetime history of mood disorder...
May 15, 2018: Lancet Psychiatry
https://www.readbyqxmd.com/read/29775837/predator-based-psychosocial-stress-model-of-ptsd-differentially-influences-voluntary-ethanol-consumption-depending-on-methodology
#8
Phillip R Zoladz, Eric D Eisenmann, Robert M Rose, Brooke A Kohls, Brandon L Johnson, Kiera L Robinson, Megan E Heikkila, Kasey E Mucher, Madelaine R Huntley
Post-traumatic stress disorder (PTSD) is a debilitating psychological disorder typified by diagnostic symptom clusters including hyperarousal, avoidance, negative cognitions and mood, and intrusive re-experiencing of the traumatic event. Patients with PTSD have been reported to self-medicate with alcohol to ameliorate hyperarousal symptoms associated with the disorder. Research utilizing rodent models of PTSD to emulate this behavioral phenomenon has thus far yielded inconsistent results. In the present study, we examined the effects of a predator-based psychosocial stress model of PTSD on voluntary ethanol consumption...
January 8, 2018: Alcohol
https://www.readbyqxmd.com/read/29775679/identification-and-validation-of-midbrain-kcnq4-regulation-of-heavy-alcohol-consumption-in-rodents
#9
Natalie S McGuier, Jennifer A Rinker, Reginald Cannady, Diana B Fulmer, Sara R Jones, Michaela Hoffman, Patrick J Mulholland
Currently available pharmacotherapies for treating alcohol use disorder (AUD) suffer from deleterious side effects and are not efficacious in diverse populations. Clinical and preclinical studies provide evidence that the Kcnq family of genes that encode KV 7 channels influence alcohol intake and dependence. KV 7 channels are a class of slowly activating voltage-dependent K+ channels that regulate neuronal excitability. Studies indicate that the KV 7 channel positive modulator retigabine can decrease dopaminergic neuron firing, alter dopamine (DA) release, and reduce alcohol intake in heavy drinking rodents...
May 15, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29774312/breast-cancer-prevention-current-approaches-and-future-directions
#10
REVIEW
Edward R Sauter
The topic of breast cancer prevention is very broad. All aspects of the topic, therefore, cannot be adequately covered in a single review. The objective of this review is to discuss strategies in current use to prevent breast cancer, as well as potential approaches that could be used in the future. This review does not discuss early detection strategies for breast cancer, including breast cancer screening. The breast is the most common site among women worldwide of noncutaneous cancer. Many clinical and genetic factors have been found to increase a woman's risk of developing the disease...
April 2018: European journal of breast health
https://www.readbyqxmd.com/read/29773157/genetic-etiology-for-alcohol-induced-cardiac-toxicity
#11
James S Ware, Almudena Amor-Salamanca, Upasana Tayal, Risha Govind, Isabel Serrano, Joel Salazar-Mendiguchía, Jose Manuel García-Pinilla, Domingo A Pascual-Figal, Julio Nuñez, Gonzalo Guzzo-Merello, Emiliano Gonzalez-Vioque, Alfredo Bardaji, Nicolas Manito, Miguel A López-Garrido, Laura Padron-Barthe, Elizabeth Edwards, Nicola Whiffin, Roddy Walsh, Rachel J Buchan, William Midwinter, Alicja Wilk, Sanjay Prasad, Antonis Pantazis, John Baski, Declan P O'Regan, Luis Alonso-Pulpon, Stuart A Cook, Enrique Lara-Pezzi, Paul J Barton, Pablo Garcia-Pavia
BACKGROUND: Alcoholic cardiomyopathy (ACM) is defined by a dilated and impaired left ventricle due to chronic excess alcohol consumption. It is largely unknown which factors determine cardiac toxicity on exposure to alcohol. OBJECTIVES: This study sought to evaluate the role of variation in cardiomyopathy-associated genes in the pathophysiology of ACM, and to examine the effects of alcohol intake and genotype on dilated cardiomyopathy (DCM) severity. METHODS: The authors characterized 141 ACM cases, 716 DCM cases, and 445 healthy volunteers...
May 22, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29769465/effects-of-oral-calcium-dosage-and-timing-on-ethanol-induced-sensitization-of-locomotion-in-dba-2-mice
#12
Chikako Shimizu, Yutaka Mitani, Youichi Tsuchiya, Toshitaka Nabeshima
Ethanol (EtOH) dosage, frequency, and paired associative learning affect the risk of alcoholism. Recently, Spanagel et al. reported that acamprosate calcium (Acam Ca) prescribed for alcoholism exerts an anti-relapse effect via Ca. Ca is contained in foods, sometimes consumed with alcohol. Therefore, we investigated the association among oral Ca ingestion, EtOH-induced locomotor sensitization, and plasma Ca levels on how to consume Ca for moderate drinking. We used DBA/2 CrSlc mice, and CaCl2 as water-soluble Ca salts...
May 16, 2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29769110/prevalence-and-determinants-of-selected-cardio-metabolic-risk-factors-among-people-living-with-hiv-aids-and-receiving-care-in-the-south-west-regional-hospitals-of-cameroon-a-cross-sectional-study
#13
Roland Cheofor Ngu, Simeon-Pierre Choukem, Christian Akem Dimala, Julius N Ngu, Gottlieb Lobe Monekosso
OBJECTIVE: Metabolic disorders and cardiovascular risk factors are not routinely assessed in the care of HIV patients in developing countries, known to have the highest disease burden. We described the prevalence and factors associated with major cardio-metabolic risk factors (obesity, diabetes and hypertension) in HIV/AIDS patients. RESULTS: The prevalence of diabetes, hypertension and obesity were 11.3% (95% CI 8.10-15.43), 24.8% (95% CI 20.1-30.0) and 14.5% (95% CI 11...
May 16, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29766837/diet-quality-and-depressive-symptoms-in-adolescence-no-cross-sectional-or-prospective-associations-following-adjustment-for-covariates
#14
Eleanor M Winpenny, Anne-Laura van Harmelen, Martin White, Esther Mf van Sluijs, Ian M Goodyer
OBJECTIVE: Adolescence is a critical period for development of depression and understanding of behavioural risk factors is needed to support appropriate preventive strategies. We examined associations between adolescent diet quality and depressive symptoms, cross-sectionally and prospectively, in a large community cohort, adjusting for behavioural and psychosocial covariates. DESIGN: Prospective community-based cohort study (ROOTS). SETTING: Secondary schools in Cambridgeshire and Suffolk, UK...
May 16, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29765172/dietary-sucrose-regulates-the-expression-of-the-cd36-gene-in-hepatic-tissue-of-rats-with-obesity-and-non-alcoholic-fatty-liver-disease-nafld
#15
Rodolfo Quintana Castro, Ida Soto Rodriguez, Rosa A Deschamps Lago, Peter Grube Pagola, Jorge Rodriguez Antolin, Adriana Peres Quintal, Jaime Rivera Rivera, Alfonso Alexander Aguilera
AIM: To evaluate the mRNA expression levels of Cd36 in adipose and hepatic tissues, in rats with NAFLD after the consumption of sucrose for 10 and 20 weeks. METHODS: Twenty Wistar rats, all nearly 21 days old were divided into two experimental groups (NAFLD-10 and NAFLD-20), that received a standard diet (2014 Teklad Global) plus 30% sucrose in their drinking water for 10 and 20 weeks and the control groups (C Groups). Variables such as body weight, food intakes, and serum parameters were measured...
May 15, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29763272/colorectal-cancer-screening-and-prevention
#16
Thad Wilkins, Danielle McMechan, Asif Talukder
Colorectal cancer is a common cause of morbidity and mortality in the United States. Most colorectal cancers arise from preexisting adenomatous or serrated polyps. The incidence and mortality of colorectal cancer can be reduced with screening of average-risk adults 50 to 75 years of age. Randomized controlled trials show evidence of reduced colorectal cancer-specific mortality with guaiac-based fecal occult blood tests and flexible sigmoidoscopy. There are no randomized controlled trials on the effectiveness of colonoscopy to reduce colorectal cancer-specific mortality; however, several randomized controlled trials comparing colonoscopy with other strategies are in progress...
May 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29761318/association-of-sugar-sweetened-beverages-consumption-with-non-alcoholic-fatty-liver-disease-a-systematic-review-and-meta-analysis
#17
REVIEW
Farzaneh Asgari-Taee, Nahid Zerafati-Shoae, Mohsen Dehghani, Masoumeh Sadeghi, Hamid R Baradaran, Shima Jazayeri
PURPOSE: The relationship between consumption of sugar sweetened beverages (SSB) and NAFLD has been reported in several epidemiological studies, but the results are inconsistent. The present systematic review and meta-analysis of observational studies was carried out to assess the relationship between sugar sweetened beverages consumption and NAFLD. METHODS: Online databases were searched systematically through December, 2016 for studies investigating association between SSB consumption and NAFLD but limited to observational studies in human...
May 14, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29758386/the-neurokinin-1-receptor-mediates-escalated-alcohol-intake-induced-by-multiple-drinking-models
#18
Michelle K Sequeira, Britta S Nelson, Hannah D Fulenwider, Courtney E King, Sadie E Nennig, Jennifer B Bohannon, Kejun Cheng, Kenner C Rice, Markus Heilig, Jesse R Schank
We have previously demonstrated that the neurokinin-1 receptor (NK1R) is upregulated in the central nucleus of the amygdala of alcohol preferring (P) rats and that this receptor mediates escalated alcohol consumption in this strain. However, it is unclear if non-genetic models of escalated consumption are also mediated by NK1R signaling, and if so, what brain regions govern this effect. In the experiments presented here, we use two methods of inducing escalated alcohol intake in outbred Wistar rats: yohimbine pretreatment and intermittent alcohol access (Monday, Wednesday, and Friday availability; 20% alcohol)...
May 3, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29758358/lipidomic-signature-of-serum-from-the-rats-exposed-to-alcohol-for-one-year
#19
Hongchun Li, Wei Xu, Linhong Jiang, Hui Gu, Menglu Li, Jiamei Zhang, Wei Guo, Pengchi Deng, Hailei Long, Qian Bu, Jingwei Tian, Yinglan Zhao, Xiaobo Cen
Alcohol abuse and its related diseases are the major risk factors for human health. Although the mechanism of alcohol-related disorders has been widely investigated, serum metabolites associated with long-term alcohol intake have not been well explored. In this study, we aimed to investigate the profiles of serum metabolites and lipid species of rats chronically exposed to alcohol, which may be involved in the pathogenesis of alcohol-associated disease. An 1 H NMR-based metabolomics and Q-TOF/MS-based lipidomics approach were applied to investigate the profile of serum metabolites and lipid species of rats administrated daily with alcohol (12% vol/vol, 10 ml/kg per day, i...
May 11, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29757972/short-term-soy-protein-isolate-feeding-prevents-liver-steatosis-and-reduces-serum-alt-and-ast-levels-in-obese-female-zucker-rats
#20
Reza Hakkak, Clinton Heath Gauss, Andrea Bell, Soheila Korourian
Non-alcoholic fatty liver disease is a common liver disorder worldwide and is associated with obesity. We investigated effects of obesity and short-term intake of soy protein with isoflavones (SPI) on body weight change, energy intake, liver steatosis, and serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and leptin levels. Seventeen lean and seventeen obese ( fa / fa ) female Zucker rats were randomly assigned to either casein or SPI diet for 8 weeks. Body weight was recorded twice weekly; feed intake was measured weekly...
May 14, 2018: Biomedicines
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