keyword
MENU ▼
Read by QxMD icon Read
search

Genes

keyword
https://www.readbyqxmd.com/read/29679912/effects-of-ugt2b7-scn1a-and-cyp3a4-on-the-therapeutic-response-of-sodium-valproate-treatment-in-children-with-generalized-seizures
#1
Weixing Feng, Shenghui Mei, Leting Zhu, Yazhen Yu, Weili Yang, Baoqin Gao, Xiaojuan Wu, Zhigang Zhao, Fang Fang
PURPOSE: This study aims to evaluate the associations between genetic polymorphisms and the effect of sodium valproate (VPA) therapy in children with generalized seizures. METHODS: A total of 174 children with generalized seizures on VPA therapy were enrolled. Steady-state trough plasma concentrations of VPA were analyzed. Seventy-six single nucleotide polymorphisms involved in the absorption, metabolism, transport, and target receptor of VPA were identified, and their associations with the therapeutic effect (seizure reduction) were evaluated using logistic regression adjusted by various influence factors...
April 14, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29679906/microrna-876-5p-inhibits-epithelial-mesenchymal-transition-and-metastasis-of-hepatocellular-carcinoma-by-targeting-bcl6-corepressor-like-1
#2
Qiuran Xu, Qiaojuan Zhu, Zhenyu Zhou, Yufeng Wang, Xin Liu, Guozhi Yin, Xiangmin Tong, Kangsheng Tu
Our previous study has reported that BCL6 corepressor like 1 (BCORL1) plays an oncogenic role in hepatocellular carcinoma (HCC) via promoting epithelial-mesenchymal transition (EMT) and tumor metastasis. However, the regulation of BCORL1 mediated by microRNAs (miRNAs) remains poorly known. The analysis of our clinical samples indicated that BCORL1 expression was markedly higher in HCC tissues than that in tumor-adjacent normal tissues. The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets revealed that high BCORL1 expression associated with high tumor grade, advanced tumor stage and poor survival of HCC patients...
April 18, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29679893/identification-of-homocysteine-suppressive-mitochondrial-etc-complex-genes-and-tissue-expression-profile-novel-hypothesis-establishment
#3
Ramon Cueto, Lixiao Zhang, Hui Min Shan, Xiao Huang, Xinyuan Li, Ya-Feng Li, Jahaira Lopez, William Y Yang, Muriel Lavallee, Catherine Yu, Yong Ji, Xiaofeng Yang, Hong Wang
Hyperhomocysteinemia (HHcy) is an independent risk factor for cardiovascular disease (CVD) which has been implicated in matochondrial (Mt) function impairment. In this study, we characterized Hcy metabolism in mouse tissues by using LC-ESI-MS/MS analysis, established tissue expression profiles for 84 nuclear-encoded Mt electron transport chain complex (nMt-ETC-Com) genes in 20 human and 19 mouse tissues by database mining, and modeled the effect of HHcy on Mt-ETC function. Hcy levels were high in mouse kidney/lung/spleen/liver (24-14 nmol/g tissue) but low in brain/heart (~5 nmol/g)...
April 4, 2018: Redox Biology
https://www.readbyqxmd.com/read/29679879/polygenic-risk-score-of-serpina6-serpina1-associates-with-diurnal-and-stress-induced-hpa-axis-activity-in-children
#4
Siddheshwar Utge, Katri Räikkönen, Eero Kajantie, Jari Lipsanen, Sture Andersson, Timo Strandberg, Rebecca M Reynolds, Johan G Eriksson, Jari Lahti
PURPOSE: Corticosteroid-binding globulin (CBG) transports glucocorticoids in blood. Variation in genes SERPINA6 encoding for CBG, SERPINA2 and SERPINA1 (serpin family A member 6, 2, and 1) have been shown to influence morning plasma cortisol and CBG in adults. However, association of this genetic variation with diurnal and stress-induced salivary cortisol remain unknown. This study aims to investigate the effect of genetic variation in SERPINA6/2/1 loci on diurnal and stress-induced salivary cortisol in children...
April 13, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29679854/thymol-attenuates-the-worsening-of-atopic-dermatitis-induced-by-staphylococcus-aureus-membrane-vesicles
#5
Hyo Il Kwon, Na Hee Jeong, So Hyun Jun, Joo Hee Son, Shukho Kim, Hyejin Jeon, Sun Chul Kang, Sang Hyun Kim, Je Chul Lee
Staphylococcus aureus membrane vesicles (MVs) aggravate atopic dermatitis (AD) through the delivery of bacterial effector molecules to host cells and the stimulation of inflammatory responses. This study investigated the inhibitory effect of thymol, a phenolic monoterpene found in essential oils derived from plants, on the worsening of AD induced by S. aureus MVs both in vitro and in vivo. The sub-minimal inhibitory concentrations of thymol disrupted S. aureus MVs. Intact S. aureus MVs induced the expression of pro-inflammatory cytokine (interleukin (IL)-1β, IL-6, and tumor necrosis factor-α) and chemokine (IL-8 and monocyte chemoattractant protein-1) genes in cultured keratinocytes, whereas thymol-treated S...
April 18, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29679838/medico-legal-investigation-in-an-explicable-case-of-congenital-central-hypoventilation-syndrome-due-to-a-rare-variant-of-the-phox2b-gene
#6
Francesco Ventura, Rosario Barranco, Tiziana Bachetti, Paolo Nozza, Ezio Fulcheri, Antonella Palmieri, Isabella Ceccherini
The heterozygous PHOX2B gene mutation is related to congenital central hypoventilation syndrome (CCHS). It is characterized by defective autonomous nervous system development leading to inadequate breathing response to hypoxia and hypercapnia, leading to hypoventilation especially during non-REM sleep, but also during waking in the more severe cases. Herein we report a case of sudden death in a 28-day-old child. The mother reported the infant was found lying on her own bed in the prone position. The infant was wearing a romper and lying in her crib without any blanket or other objects...
April 17, 2018: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29679834/microeukaryotic-biogeography-in-the-typical-subtropical-coastal-waters-with-multiple-environmental-gradients
#7
Huajun Zhang, Xiaolin Huang, Lei Huang, Fangjian Bao, Shangling Xiong, Kai Wang, Demin Zhang
The determinants of microeukaryotic biogeography in coastal waters at a regional scale remain largely unclear. The coastal northern Zhejiang (in the East China Sea) is a typical subtropical marine ecosystem with multiple environmental gradients that has been extensively perturbed by anthropogenic activities. Thus, it is a valuable region to investigate the key drivers that shape microbial biogeography. We investigated microeukaryotic communities in surface waters from 115 stations in this region using 18S ribosomal RNA gene amplicon sequencing...
April 18, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29679832/natural-revegetation-of-a-semiarid-habitat-alters-taxonomic-and-functional-diversity-of-soil-microbial-communities
#8
Yanqing Guo, Xiaotian Chen, Yuanyuan Wu, Lu Zhang, Jimin Cheng, Gehong Wei, Yanbing Lin
Revegetation of degraded lands has a profound impact on the maintenance and stability of ecosystem processes. However, the impacts of this land use change on functional diversity of soil microbial communities are poorly understood. Here, using 16S rRNA gene amplicon and shotgun metagenomic sequencing, we compared the taxonomic and functional communities of soil microbiome, and analyzed the effects of plant diversity and soil chemical properties, in a chronosequence of restored ex-farmland that had been naturally revegetated to grassland over periods of 5, 15 and 30years with adjacent farmland, on the Loess Plateau, China...
April 18, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29679803/development-of-the-plant-derived-peptide-lunasin-as-an-anticancer-agent
#9
REVIEW
Saleha B Vuyyuri, Chris Shidal, Keith R Davis
The health benefits of soy consumption have long been recognized. An important potential benefit is the linkage of soy consumption with reduced cancer risk. One emerging factor that may confer the anticancer effects of soy is the peptide lunasin. Lunasin has both chemopreventive and therapeutic activities against a variety of carcinogens and cancer types. A novel feature of lunasin is that it contains multiple functional domains that can modulate gene expression through effects on histone acetylation and integrin signaling...
April 18, 2018: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29679800/synthetic-investigation-of-binary-ternary-cr-iii-hydroxycarboxylic-acid-aromatic-chelator-systems-structure-specific-influence-on-adipogenic-biomarkers-linked-to-insulin-mimesis
#10
O Tsave, C Gabriel, M Kafantari, M Yavropoulou, J G Yovos, C P Raptopoulou, V Psycharis, A Terzis, C Mateescu, A Salifoglou
In an attempt to understand the aqueous interactions of Cr(III) with low-molecular mass physiological ligands and examine its role as an adipogenic metallodrug agent in Diabetes mellitus II, the pH-specific synthesis in the binary-ternary Cr(III)-(HA = hydroxycarboxylic acid)-(N,N)-aromatic chelator (AC) (HA = 2-hydroxyethyl iminodiacetic acid/heidaH2 , quinic acid; AC = 1,10-phenanthroline/phen) systems was pursued, leading to four new crystalline compounds. All materials were characterized by elemental analysis, UV-Visible, FT-IR, and ESI-MS spectroscopy, cyclic voltammetry, and X-Ray crystallography...
February 10, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29679791/phosphorodiamidate-morpholino-targeting-the-5-untranslated-region-of-the-zikv-rna-inhibits-virus-replication
#11
Waldemar Popik, Atanu Khatua, James E K Hildreth, Benjamin Lee, Donald J Alcendor
BACKGROUND: Zika virus (ZIKV) infection has been associated with microcephaly in infants. Currently there is no treatment or vaccine. Here we explore the use of a morpholino oligonucleotide targeted to the 5' untranslated region (5'-UTR) of the ZIKV RNA to prevent ZIKV replication. METHODS: Morpholino DWK-1 inhibition of ZIKV replication in human glomerular podocytes was examined by qRT-PCR, reduction in ZIKV genome copy number, western blot analysis, immunofluorescence and proinflammatory cytokine gene expression...
April 18, 2018: Virology
https://www.readbyqxmd.com/read/29679762/scavenger-receptor-b-promotes-bacteria-clearance-by-enhancing-phagocytosis-and-attenuates-white-spot-syndrome-virus-proliferation-in-scylla-paramamosian
#12
Tongtong Kong, Yi Gong, Yan Liu, Xiaobo Wen, Ngoc Tuan Tran, Jude Juventus Aweya, Yueling Zhang, Hongyu Ma, Huaiping Zheng, Shengkang Li
Phagocytosis and apoptosis are key cellular innate immune responses against bacteria and virus in invertebrates. Class B scavenger receptors (SRBs), which contain a CD36 domain, are critical pattern recognition receptors (PRRs) of phagocytosis for bacteria and apoptotic cells. In the present study, we identified a member of SRB subfamily in mud crab Scylla paramamosain, named Sp-SRB. The full-length cDNA of Sp-SRB is 2593 bp with a 1629 bp open reading frame (ORF) encoding a putative protein of 542 amino acids, and predicted to contain a CD36 domain with two transmembrane regions at the C- and N-terminals...
April 18, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29679761/expression-profiling-and-microbial-ligand-binding-analysis-of-high-mobility-group-box-1-hmgb1-in-turbot-scophthalmus-maximus-l
#13
Xin Cai, Chengbin Gao, Baofeng Su, Fenghua Tan, Ning Yang, Guodong Wang
High-mobility group box 1 (HMGB1), a highly conserved DNA-binding protein, was involved in nucleosome formation and transcriptional regulation, and can also act as an extracellular cytokine to trigger inflammation and immune responses. In this study, we identified a HMGB1 gene in turbot (Scophthalmus maximus L.). The full-length SaHMGB1 cDNA includes an open reading frame of 615 bp which encoded a 204 amino acid polypeptide with an estimated molecular mass of 23.19°kDa. SaHMGB1 was most closely related to several fish HMGB1 and shared 74...
April 18, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29679759/bax-inhibitor-1-from-orange-spotted-grouper-epinephelus-coioides-involved-in-viral-infection
#14
Jia Cai, Shina Wei, Yishan Lu, Zaohe Wu, Qiwei Qin, Jichang Jian
Bax inhibitor-1 (BI-1) is a conserved anti-apoptotic protein that suppresses endoplasmic reticulum (ER) stress-induced cell death. However, the function of fish BI-1 is not quite clear. In the present study, a bi-1 homolog (Ecbi-1) from orange spotted grouper, Epinephelus coioides was identified and its roles in viral infection were investigated. EcBI-1 encoded 237 amino acids protein, contained six transmembrane regions and a conservative C-terminus motif. Ecbi-1 predominantly expressed in kidney and spleen of healthy grouper...
April 18, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29679758/validation-and-bioinformatic-analysis-of-propofol-induced-differentially-expressed-micrornas-in-primary-cultured-neural-stem-cells
#15
Yan Li, Youtan Liu, Jun Fan, Quan Zhou, Xiuling Song, Zhiyong Peng, Zaisheng Qin, Tao Tao
Propofol, a widely used intravenous anesthetic, was previously considered as a neuroprotective agent. Recently, however, accumulating evidence suggests that it may cause neurotoxicity, especially in the development of neural stem cells (NSCs). The potential mechanisms contributing to propofol-induced neurotoxicity during neurogenesis, such as those involving microRNAs (miRNAs), are still unknown. In this study, a total of 27 differentially expressed miRNAs were identified in our initial screen and 6 miRNAs were validated by qRT-PCR...
April 18, 2018: Gene
https://www.readbyqxmd.com/read/29679757/molecular-characterization-of-cu-zn-sod-gene-in-asian-clam-corbicula-fluminea-and-mrna-expression-and-enzymatic-activity-modulation-induced-by-metals
#16
Xie Yanhai, Chen Hongbing, Zheng Shuangyan, Zhang Xiali, Mu Songniu
The copper/zinc superoxide dismutase (Cu/Zn SOD) could effectively eliminate reactive oxygen species (ROS). In this study, the cDNA sequence of Cu/Zn SOD from Corbicula fluminea (designated as CfCu/Zn SOD) was cloned by the rapid amplification of cDNA ends (RACE) approaches. The full-length cDNA of CfCu/Zn SOD was of 1288 bp, including a 465 bp ORF encoding a protein of 154 amino acids. Two SOD family signatures were identified in CfCu/Zn SOD amino acids sequence. Multiple sequence alignments indicated that CfCu/Zn SOD amino acid sequences exhibited high similarities to those of other species...
April 18, 2018: Gene
https://www.readbyqxmd.com/read/29679756/myh9-structure-functions-and-role-of-non-muscle-myosin-iia-in-human-disease
#17
REVIEW
Alessandro Pecci, Xuefei Ma, Anna Savoia, Robert S Adelstein
The MYH9 gene encodes the heavy chain of non-muscle myosin IIA, a widely expressed cytoplasmic myosin that participates in a variety of processes requiring the generation of intracellular chemomechanical force and translocation of the actin cytoskeleton. Non-muscle myosin IIA functions are regulated by phosphorylation of its 20 kDa light chain, of the heavy chain, and by interactions with other proteins. Variants of MYH9 cause an autosomal-dominant disorder, termed MYH9-related disease, and may be involved in other conditions, such as chronic kidney disease, non-syndromic deafness, and cancer...
April 18, 2018: Gene
https://www.readbyqxmd.com/read/29679746/prevalence-of-cfr-in-enterococcus-faecalis-strains-isolated-from-swine-farms-in-china-predominated-cfr-carrying-pcppf5-like-plasmids-conferring-non-linezolid-resistance-phenotype
#18
Liang-Xing Fang, Jia-Hong Duan, Mu-Ya Chen, Hui Deng, Hua-Qing Liang, Yan Q Xiong, Jian Sun, Ya-Hong Liu, Xiao-Ping Liao
The cfr gene associated with linezolid resistance has attracted wide attention. However, little is known about its prevalence and mode of transmission in Enterococcus faecalis. In this study, we investigate the prevalence and genetic environment of the cfr gene in 91 E. faecalis isolates collected from swine faecal swabs in 30 farms in Guangdong Province, China in 2012. A relatively high prevalence of cfr was identified in E. faecalis isolates (11/91, 12.1%) by PCR. All the cfr-positive E. faecalis strains had a multidrug-resistance phenotype including erythrocin, tetracycline, gentamicin, kanamicin and ciprofloxacin, except vancomycin and linezolid...
April 18, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29679745/integrated-genomic-and-metabolomic-profiling-of-isc1-an-emerging-leishmania-donovani-population-in-the-indian-subcontinent
#19
Bart Cuypers, Maya Berg, Hideo Imamura, Franck Dumetz, Géraldine De Muylder, Malgorzata A Domagalska, Suman Rijal, Narayan Raj Bhattarai, Ilse Maes, Mandy Sanders, James A Cotton, Pieter Meysman, Kris Laukens, Jean-Claude Dujardin
Leishmania donovani is the responsible agent for visceral leishmaniasis (VL) in the Indian subcontinent (ISC). The disease is lethal without treatment and causes 0.2 to 0.4 million cases each year. Recently, reports of VL in Nepalese hilly districts have increased as well as VL cases caused by L. donovani from the ISC1 genetic group, a new and emerging genotype. In this study, we perform for the first time an integrated, untargeted genomics and metabolomics approach to characterize ISC1, in comparison with the Core Group (CG), main population that drove the last outbreak of VL in the ISC...
April 18, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29679718/identification-of-differential-phosphorylation-and-sub-cellular-localization-of-the-metastasis-suppressor-ndrg1
#20
Kyung Chan Park, Sharleen V Menezes, Danuta S Kalinowski, Sumit Sahni, Patric J Jansson, Zaklina Kovacevic, Des R Richardson
The metastasis suppressor, N-myc downstream regulated gene-1 (NDRG1), exhibits pleiotropic activity, inhibiting metastasis of various tumor-types, while being correlated with metastasis in others. Notably, NDRG1 phosphorylation and cleavage are associated with its function, although it is unclear if these modifications occur universally, or selectively, in different cancer cell-types and if it contributes to its pleiotropy. Considering the suggested DNA repair role of nuclear NDRG1, the effects of the above post-translational modifications on its nuclear localization was examined...
April 18, 2018: Biochimica et Biophysica Acta
keyword
keyword
7443
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"