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Ovarian reserve assessment

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https://www.readbyqxmd.com/read/28338235/overexpression-of-hsa-mir-320-is-associated-with-invasion-and-metastasis-of-ovarian-cancer
#1
Wei Wang, Juan Yang, Yuan-Yuan Xiang, Jie Pi, Jiang Bian
Ovarian cancer is one of the most common malignant tumor of female genital organs which ranks the third morbidity. We aimed to provide a better understanding of the mechanism of invasion and metastasis of ovarian cancer. The ovarian cancer samples were downloaded from GEO. Then clustering was performed to classify the stage of miRNAs based on the difference of prognosis and metastasis. Furthermore, the miRNAs model was build and the survival analysis processes was performed to observe the influence on prognosis, invasion and metastasis...
March 24, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28337831/interleukin-1-alpha-deficiency-increases-the-expression-of-follicle-stimulating-hormone-receptors-in-granulosa-cells
#2
Shiri Uri-Belapolsky, Irit Miller, Aviv Shaish, Mattan Levi, Dror Harats, Lihi Ninio-Many, Yehuda Kamari, Ruth Shalgi
Follicle-stimulating hormone receptor (FSHR) is a pivotal regulator of ovarian response to hormonal stimulation. Inflammatory conditions have been linked to lower FSHR expression in granulosa cells (GCs) as well as an attenuated response to hormonal stimulation. The current study aimed to reveal if deficiency and/or blockage of the pro-inflammatory cytokine interleukin 1-alpha (IL1A) increased Fshr expression in rodent GCs. We found elevated Fshr transcript abundance, as assessed by quantitative PCR, in primary GCs isolated from Il1a-knockout compared to wild-type mice, and that the expression of FSHR is significantly higher in Il1a-knockout compared to wild-type ovaries...
March 24, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28333275/anti-m%C3%A3-llerian-hormone-inhibits-activation-and-growth-of-bovine-ovarian-follicles-in-vitro-and-is-localized-to-growing-follicles
#3
M Y Yang, R A Cushman, J E Fortune
STUDY QUESTION: Does anti-Müllerian hormone (AMH) inhibit activation (initiation of growth) of primordial follicles and attenuate the growth of primary follicles in cattle, an excellent animal model for human ovarian follicular development? SUMMARY ANSWER: AMH inhibited activation of bovine primordial follicles and attenuated the growth of activated follicles in vitro. WHAT IS KNOWN ALREADY: In mice null mutant for AMH, the pool of primordial follicles is depleted prematurely and AMH inhibits follicle activation in vitro...
March 17, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28333271/impact-of-thyroid-autoimmunity-in-euthyroid-women-on-live-birth-rate-after-iui
#4
D Unuane, B Velkeniers, B Bravenboer, P Drakopoulos, H Tournaye, J Parra, M De Brucker
STUDY QUESTION: Does thyroid autoimmunity (TAI) predict live birth rate in euthyroid women after one treatment cycle in IUI patients? SUMMARY ANSWER: TAI as such does not influence pregnancy outcome after IUI treatment. WHAT IS KNOWN ALREADY: The role of TAI on pregnancy outcome in the case of IVF/ICSI is largely debated in the literature. This is the first study to address this issue in the case of IUI. STUDY DESIGN, SIZE, DURATION: This was a retrospective cohort study...
February 23, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28321529/the-cumulative-dose-of-gonadotropins-used-for-controlled-ovarian-stimulation-does-not-influence-the-odds-of-embryonic-aneuploidy-in-patients-with-normal-ovarian-response
#5
Lucky Sekhon, Kathryn Shaia, Anthony Santistevan, Karen Hunter Cohn, Joseph A Lee, Piraye Yurttas Beim, Alan B Copperman
OBJECTIVE: Controlled ovarian hyperstimulation (COH) promotes multifollicular growth, increasing the chance of obtaining euploid embryos that will successfully implant. Whether aneuploidy is increased from COH with exogenous gonadotropins interfering with natural selection of dominant follicles is a concern. This study evaluates the association between gonadotropin exposure and aneuploidy. METHODS: This is a retrospective cohort study of 828 patients that underwent 1122 IVF cycles involving controlled ovarian stimulation and trophectoderm biopsy for preimplantation genetic screening (PGS), from 2010 to 2015...
March 20, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28319016/anti-m%C3%A3-llerian-hormone-kinetics-in-pregnancy-and-post-partum-a-systematic-review
#6
REVIEW
Sarah McCredie, William Ledger, Christos A Venetis
The aim of this systematic review is to critically appraise the available evidence regarding the kinetics of anti-Müllerian hormone (AMH) during pregnancy and post-partum. A systematic literature search was conducted in MEDLINE, Embase, CENTRAL, Scopus and Web of Science on 14 December 2015, aiming to identify studies providing data on the serum concentration of AMH in women at various stages of gestation and post-partum. There was a total of 1719 participants across eight studies. Seven out of the eight studies reported a decline in serum AMH concentration with advancing gestational age...
February 24, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28317122/an-anthropomorphic-abdominal-phantom-for-deformable-image-registration-accuracy-validation-in-adaptive-radiation-therapy
#7
Yuliang Liao, Linjing Wang, Xiangdong Xu, Haibin Chen, Jiawei Chen, Guoqian Zhang, Huaiyu Lei, Ruihao Wang, Shuxu Zhang, Xuejun Gu, Xin Zhen, Linghong Zhou
PURPOSE: To design and construct a three-dimensional (3D) anthropomorphic abdominal phantom for geometric accuracy and dose summation accuracy evaluations of deformable image registration (DIR) algorithms for adaptive radiation therapy (ART). METHOD: Organ molds, including liver, kidney, spleen, stomach, vertebra and two metastasis tumors, were 3D printed using contours from an ovarian cancer patient. The organ molds were molded with deformable gels made of different mixtures of polyvinyl chloride (PVC) and the softener dioctyl terephthalate...
March 20, 2017: Medical Physics
https://www.readbyqxmd.com/read/28302175/prolonged-hypothyroidism-severely-reduces-ovarian-follicular-reserve-in-adult-rats
#8
Li Meng, Eddy Rijntjes, Hans J M Swarts, Jaap Keijer, Katja J Teerds
BACKGROUND: There is substantial evidence both in humans and in animals that a prolonged reduction in plasma thyroid hormone concentration leads to reproductive problems, including disturbed folliculogenesis, impaired ovulation and fertilization rates, miscarriage and pregnancy complications. The objective of the present study is to examine the consequences of chronic hypothyroidism, induced in adulthood, for the size of the ovarian follicle pool. In order to investigate this, adult female rats were provided either a control or an iodide deficient diet in combination with perchlorate supplementation to inhibit iodide uptake by the thyroid...
March 16, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28293053/effect-of-melatonin-on-the-outcome-of-assisted-reproductive-technique-cycles-in-women-with-diminished-ovarian-reserve-a-double-blinded-randomized-clinical-trial
#9
Bahia Namavar Jahromi, Sara Sadeghi, Shohreh Alipour, Mohammad Ebrahim Parsanezhad, Shaghayegh Moradi Alamdarloo
Diminished ovarian reserve (DOR) significantly decreases the success rate of the assisted reproductive technique (ART). In this study, we assessed the effect of melatonin on the ART outcomes in women with DOR. A double-blinded, randomized, clinical trial was performed on 80 women with DOR as a pilot study in Shiraz, between 2014 and 2015. DOR was defined as the presence of 2 of the following 3 criteria: 1) anti-Müllerian hormone ≤1, 2) follicle-stimulating hormone ≥10, and 3) bilateral antral follicle count ≤6...
January 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28284038/3d-and-4d-studies-from-human-reproduction-to-perinatal-medicine
#10
Sonal Panchal, Asim Kurjak, Chaitanya Nagori
Three-dimensional ultrasound (3D US) is a modality of choice for prenatal diagnosis of congenital malformations. But 3D-four-dimensional US(4D US) is of utmost importance also to achieve pregnancy. 3D US plays an important role for diagnosis of PCO, to assess ovarian reserve and response and thus to decide optimum stimulation protocols. It adds to the information on follicular maturity and endometrial receptivity, thus improving the chances to achieve pregnancy for patients under treatment for fertility. 3D hystero-contrast-salpingography (HyCoSy) has also proved itself to be one of the best modalities for assessment of tubal patency...
March 11, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28273351/use-of-cancer-antigen-125-cancer-antigen-19-9-and-the-neutrophil-to-lymphocyte-ratio-to-diagnose-mature-cystic-teratoma-with-torsion
#11
Yuan-Qiu Wang, Wei-Ting Xia, Fang Wang, Xin-Xin Zhuang, Fei-Yun Zheng, Feng Lin
OBJECTIVE: To determine the efficacy of serum levels of cancer antigen 125 (CA125) and cancer antigen 19-9 (CA19-9), and the neutrophil-to-lymphocyte ratio (NLR) for diagnosis of mature cystic teratoma (MCT) with torsion. METHODS: A retrospective medical record review was conducted of data for women who had undergone surgery for ovarian MCT at the First Affiliated Hospital of Wenzhou Medical University, China, between January 1, 2008, and January 1, 2015. Patients with torsion and a control group who underwent surgery on the same days were identified...
March 8, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28272468/accuracy-and-safety-verification-of-ovarian-reserve-assessment-technique-for-ovarian-tissue-transplantation-using-optical-coherence-tomography-in-mice-ovary
#12
Seido Takae, Kosuke Tsukada, Yorino Sato, Naoki Okamoto, Tai Kawahara, Nao Suzuki
Except for histological study, there are currently no suitable techniques available for the detection and identification of primordial follicles in ovary of primary ovarian insufficiency patients who have undetectable AMH levels. Also, the ability to locate and quantify follicles on ovarian cortex strips, without fixation, is valuable for patients who could undergo subsequent successful ovarian tissue transplantation. Although optical coherence tomography (OCT) is a well-established high resolution imaging technique without fixation commonly applied in biomedicine, few reports are available on ovarian tissue imaging...
March 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28226180/a33-shows-similar-sensitivity-to-but-is-more-specific-than-cdx2-as-an-immunomarker-of-colorectal-carcinoma
#13
Newton A C S Wong, Lukasz A Adamczyk, Shanna Evans, Jayne Cullen, Anca Oniscu, Karin A Oien
AIMS: CDX2 is widely used as a sensitive and specific immunomarker for colorectal carcinoma (CRC) but neither this sensitivity nor specificity is absolute. This study is the first known comparison of CDX1 and A33 against CDX2 as immunomarkers for CRC. METHODS AND RESULTS: As a pilot study, whole sections of 51 cases of liver metastatic carcinoma of different origins - colorectum (n=32), breast (n=3), oesophagogastric tract (n=4), lung (n=3), pancreas (n=8), and prostate (n=1) - were immunostained with CDX1, CDX2 and A33...
February 22, 2017: Histopathology
https://www.readbyqxmd.com/read/28223181/the-effect-of-salpingectomy-on-ovarian-function
#14
REVIEW
Alexander Kotlyar, Julian Gingold, Shirley Shue, Tommaso Falcone
OBJECTIVE: To review the literature concerning the effects of salpingectomy on ovarian function as assessed using measures of ovarian reserve and outcomes from in-vitro fertilization and spontaneous pregnancy cycles. BACKGROUND: Tubal surgery is performed for a variety of indications in gynecology. Salpingectomy is the most aggressive form of tubal surgery and may be performed for potential risk reduction for epithelial ovarian cancer, sterilization, ectopic pregnancy and as a method to enhance fertility in the setting of a hydrosalpinx...
February 18, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28208941/anti-mullerian-hormone-a-marker-of-ovarian-reserve-and-its-association-with-polycystic-ovarian-syndrome
#15
Anil Kumar Verma, Sarita Rajbhar, Jyoti Mishra, Mayank Gupta, Mratunjai Sharma, Geeta Deshmukh, Wahid Ali
INTRODUCTION: Anti-Mullerian Hormone (AMH) is a useful endocrine marker for assessing the ovarian reserve. AMH serum level reflects the number of follicles that have made the transition from the primordial pool into the growing follicle pool, and it is not controlled by gonadotropins. AIM: The present study was conducted to correlate serum AMH levels with Polycystic Ovarian Syndrome (PCOS) and type of treatment protocol. MATERIALS AND METHODS: Serum AMH levels were performed in the early follicular phase (on 2(nd) day of menstrual cycle) both in infertile females including PCOS and control women...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28135602/anti-m%C3%A3-llerian-hormone-levels-and-evolution-in-women-of-reproductive-age-with-breast-cancer-treated-with-chemotherapy
#16
REVIEW
T Fréour, P Barrière, D Masson
BACKGROUND: Long-term consequences of cancer treatments in young women, and especially fertility issues, are gaining attention as survival rates increase. Breast cancer is the most frequent malignancy in women of reproductive age. AIM: The purpose of this review is to describe serum anti-müllerian hormone (AMH) level at diagnosis and its evolution during and after chemotherapy in women of reproductive age treated for breast cancer. Second, the impact of taxanes on AMH, the association between AMH and amenorrhea, and the comparison of AMH with other hormonal markers of ovarian reserve were studied...
January 27, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28132758/specific-ranges-of-anti-mullerian-hormone-and-antral-follicle-count-correlate-to-provide-a-prognostic-indicator-for-ivf-outcome
#17
K N Keane, V F Cruzat, S R Wagle, N G Chaudhary, P Newsholme, J L Yovich
Advanced female age correlates with reduced ovarian reserve (OR) and is the primary factor underlying the limitation of success rates in Assisted Reproductive Technology (ART). Currently, predicted ovarian response to gonadotrophin stimulation is determined using transvaginal ultrasound to measure antral follicle count (AFC), an indirect measure of OR. However, assessing the level of anti-Mullerian hormone (AMH) has more recently been shown to correlate with OR, and its application has been adopted widely. This retrospective study was designed to determine the relationship between novel ranges of AMH and AFC in patients undergoing ART...
January 26, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/28111093/effects-of-perfluorinated-chemicals-on-thyroid-function-markers-of-ovarian-reserve-and-natural-fertility
#18
Natalie M Crawford, Suzanne E Fenton, Mark Strynar, Erin P Hines, David A Pritchard, Anne Z Steiner
Perfluorinated chemicals (PFCs) can act as endocrine-disrupting chemicals, but there has been limited study of their effects on ovarian reserve or fecundability. 99 women, 30-44 years old, without infertility were followed until pregnancy. Initially, serum was evaluated for Antimullerian hormone (AMH), thyroid hormones: thyroid stimulating hormone (TSH), thyroxine (T4), free thyroxine (fT4), and triiodothyronine (T3), and PFCs: perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA), and perfluorohexanesulfonic acid (PFHxS)...
January 19, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28106643/imaging-and-the-infertility-evaluation
#19
Roohi Jeelani, Elizabeth E Puscheck
Ultrasound (US) has transformed the fertility evaluation. With 1 consultation, blood work and 1 to 2 USs, the female fertility status can be fully evaluated. The initial US is best done early in the follicular cycle to evaluate the pelvic anatomy and ovarian reserve. A three-dimensional US is important to evaluate for uterine anomalies and color Doppler for any masses. A mid-cycle saline infusion sonohysterogram assesses the endometrial cavity better than a hysterosalpingogram as it identifies the cause of any filling defects...
March 2017: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28066837/age-specific-nomograms-for-follicle-stimulating-hormone-and-anti-mullerian-hormone-a-pilot-study-in-ile-ife-nigeria
#20
Omoladun Temitope Okunola, Olusegun Kayode Ajenifuja, Morebise Olabisi Loto, Afolabi Salawu, Oluseyi Stephen Omitinde, Joel Akande, Elizabeth Oke
BACKGROUND: Assessment of ovarian reserve is one of the steps in the management of infertile couples. Follicle Stimulating hormone (FSH) and anti-Müllerian hormone (AMH) are commonly used ovarian reserve markers in Africa. However, there is paucity of age-specific reference values for FSH and AMH among the African population. OBJECTIVE: This study aimed at conducting a pilot study for generation of age-specific nomograms for FSH and AMH among fertile women in Ile-Ife, Nigeria...
December 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
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