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Ovarian reserve assessment

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https://www.readbyqxmd.com/read/28914967/chemotherapy-response-score-is-a-useful-histological-predictor-of-prognosis-in-high-grade-serous-carcinoma
#1
Authors Priya Singh, Vikrant Kaushal, Bhavana Rai, Arvind Rajwanshi, Nalini Gupta, Pranab Dey, Rashi Garg, Manish Rohilla, Vanita Suri, Sushmita Ghoshal, Radhika Srinivasan
AIM: High grade serous carcinoma (HGSC) is the most common tubal/ovarian malignant tumor usually presenting in advance stage. Interval debulking surgery (IDS) post neoadjuvant chemotherapy (NACT) has been increasingly in use for the management of these patients. Chemotherapy response score (CRS) has been proposed for grading response of tubo-ovarian HGSC to NACT on the basis of examination of IDS specimens. Our aim was to evaluate CRS in post NACT cases, assess the interobserver agreement and correlate it to overall and progression- free survival...
September 15, 2017: Histopathology
https://www.readbyqxmd.com/read/28911998/establishing-age-specific-reference-intervals-for-anti-m%C3%A3-llerian-hormone-in-adult-chinese-women-based-on-a-multicenter-population
#2
Xinqi Cheng, Qiong Zhang, Min Liu, Shijun Li, Zhihua Tao, Kiyoshi Ichihara, Songlin Yu, Kai Zhang, Pengchang Li, Jianhua Han, Ling Qiu
AIM OF THIS STUDY: Anti-Müllerian hormone (AMH) is useful for the assessment of ovarian reserve and treatment of individualized in vitro fertilization (IVF). The aim of this study is to establish AMH reference interval for adult Chinese women on the Beckman Beckman DxI 800 platform. MATERIAL AND METHODS: From May to September 2013, serum from 1169 apparently healthy adult females from five representative cities in China (Beijing, Hangzhou, Guangzhou, Dalian and Urumqi) were collected, and AMH was analyzed on the platform of Beckman DxI 800 automated chemiluminescence immunoassay...
September 12, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28889522/salidroside-a-chemopreventive-glycoside-diminishes-cytotoxic-effect-of-cisplatin-in-vitro
#3
Martina Zduriencikova, Dana Cholujova, Jozef Duraj, Maria Mastihubova, Vladimir Mastihuba, Elena Karnisova Potocka, Eliska Galova, Andrea Sevcovicova, Martina Klapakova, Eva Horvathova
Natural products represent the source or the inspiration for the majority of the active ingredients of medicines because of their structural diversity and a wide range of biological effects. Our aims in this study were (i) to synthesize enzymatically salidroside (SAL), the most effective phenylethanoid glycoside in Rhodiola species; (ii) to examine its antioxidant capacity using cell-free assays (reducing power, DPPH radicals scavenging and Fe(2+) -chelating assays); (iii) to assess its DNA-protective potential on plasmid DNA (DNA topology assay) and in HepG2 cells (comet assay) damaged by Fe(2+) ions and hydrogen peroxide, respectively; and (iv) to investigate the effects of SAL, cisplatin (CDDP) and combined treatments of SAL + CDDP on cell viability (MTT test), level of DNA damage (comet assay), proliferation, cell cycle (flow cytometry) and the expression of signalling molecules associated with cell growth and apoptotic pathways (western immunoblotting)...
September 10, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28887829/using-public-data-for-comparative-proteome-analysis-in-precision-medicine-programs
#4
Christopher S Hughes, Gregg B Morin
Maximizing the clinical utility of information obtained in longitudinal precision medicine programs would benefit from robust comparative analyses to known information to assess biological features of patient material, in the hopes of identifying the underlying features that drive their disease phenotype. In this study we investigate the potential for utilizing publically deposited mass spectrometry-based proteomics data to perform inter-study comparisons of cell line or tumour tissue materials. Using in-depth quantitative proteomics data acquired from analysis of ovarian cancer cell lines, we demonstrate the robust recapitulation of observable gene expression dynamics between individual studies carried out using significantly different methodologies...
September 9, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28881264/is-endometrioma-associated-damage-to-ovarian-reserve-progressive-insights-from-ivf-cycles
#5
Laura Benaglia, Marta Castiglioni, Alessio Paffoni, Veronica Sarais, Paolo Vercellini, Edgardo Somigliana
OBJECTIVE: The relation between endometriomas and damage to ovarian reserve remains controversial. In this study, we hypothesized that this damage may not be present at the time of endometrioma formation but may conversely gradually develop over time. STUDY DESIGN: To investigate the possibility of a time-related detrimental effect of endometriomas on ovarian reserve, we retrospectively selected 29 women with unilateral cysts who underwent at least two IVF cycles at least 6 months apart and evaluated ovarian responsiveness over time...
September 1, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28877720/reduced-ovarian-reserve-in-young-early-breast-cancer-patients-preliminary-data-from-a-prospective-cohort-trial
#6
Antonia Wenners, Jana Grambach, Juliane Koss, Nicolai Maass, Walter Jonat, Andreas Schmutzler, Christoph Mundhenke
BACKGROUND: The numerous side effects of chemotherapy in patients with breast cancer are well known. However, the precise effects of chemotherapy on ovarian function in premenopausal women are poorly investigated. The patients are at risk of developing sexual hormone deficiency and impaired fertility. This prospective cohort study addresses predictive parameters of ovarian reserve after chemotherapy. METHODS: Fifty-one premenopausal women (28-46 years) with primary breast cancer were included in the trial...
September 6, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28868628/ovarian-cancer-stem-cells-promote-tumour-immune-privilege-and-invasion-via-ccl5-and-regulatory-t-cells
#7
Yanan You, Yiying Li, Ming Li, Lei Mi, Mengyao Wu, Ying Qu, Yan Yuan, Tong Chen, Hua Jiang
Emerging evidence indicates a link between the increased proportion of regulatory T cells (Tregs) and reduced survival in patients who have been diagnosed with cancer. Cancer stem cells (CSCs) have been indicated to play a vital role in tumour initiation, drug resistance and recurrence. However, the relationship between Tregs and CSCs remains largely unknown. Here, we sorted out ovarian cancer stem-like side population (SP) cells and CD133(+) cells to investigate the influence of ovarian CSCs on Tregs. Among the various immune-related molecules that we assessed, C-C motif chemokine ligand 5 (CCL5) was the most elevated in ovarian CSCs relative to that in the non-CSCs...
September 4, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28858684/what-women-want-a-scoping-survey-on-women-s-knowledge-attitudes-and-behaviours-towards-ovarian-reserve-testing-and-egg-freezing
#8
Yvonne O'Brien, Fiona Martyn, Louise E Glover, Mary B Wingfield
OBJECTIVE: We aimed to investigate women's knowledge, attitudes and behaviours towards ovarian reserve testing and egg freezing for non-medical reasons in the general population. STUDY DESIGN: This was a cross-sectional survey study of 663 women aged 18-44 years which assessed female perception of ovarian reserve testing and oocyte cryopreservation. An online forum was used to deliver the survey through the use of two social media sites. Participants were recruited through the technique of "snowballing", whereby existing study subjects recruited others from among their acquaintances...
August 19, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28857180/clinical-characteristics-and-prognostic-inflection-points-among-long-term-survivors-of-advanced-epithelial-ovarian-cancer
#9
Joo-Hyuk Son, Tae-Wook Kong, Jiheum Paek, Kwan-Heup Song, Suk-Joon Chang, Hee-Sug Ryu
OBJECTIVE: To assess clinical characteristics of long-term survivors of advanced epithelial ovarian cancer (EOC) to define a prognostic inflection point for long-term survival. METHODS: A retrospective analysis was undertaken of patients with FIGO stage III or IV EOC treated at one center in South Korea from 2000 to 2012. Patients who survived 5 years or more were identified, and the periods of disease-free survival and overall survival were evaluated for prognostic inflection points to indicate long-term survival...
August 31, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28856867/changes-in-anti-m%C3%A3-llerian-hormone-levels-as-a-biomarker-for-ovarian-reserve-after-ultrasound-guided-high-intensity-focused-ultrasound-treatment-of-adenomyosis-and-uterine-fibroid
#10
J-S Lee, G-Y Hong, K-H Lee, T-E Kim
OBJECTIVE: To assess the changes in antimüllerian hormone (AMH) levels after ablation for symptomatic uterine fibroids and adenomyosis using ultrasound-guided high-intensity focused ultrasound (USgHIFU). DESIGN: A prospective study. SETTING: Gynaecological department in multiple hospitals in South Korea. POPULATION: Patients with uterus fibroids and adenomyosis. METHODS: Seventy-nine women with symptomatic uterine fibroids and adenomyosis who met the inclusion criteria were enrolled in our study between January 2014 and December 2014...
August 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28846864/anti-m%C3%A3-llerian-hormone-levels-and-fecundability-in-women-with-a-natural-conception
#11
Helene W Hvidman, Anne Kirstine Bang, Lærke Priskorn, Thomas Scheike, Kathrine Birch Petersen, Loa Nordkap, Anne Loft, Anja Pinborg, Ann Tabor, Niels Jørgensen, Anders Nyboe Andersen
OBJECTIVES: To investigate the association between anti-Müllerian hormone (AMH), a well-established marker of the ovarian reserve, and time-to-pregnancy (TTP) in natural conceptions, and to assess changes in serum-AMH in early pregnancy. STUDY DESIGN: A cross sectional study comprising 279 women aged 21-42 years with a natural conception recruited during 2012-2014. AMH was measured in gestational week 10-19. AMH z-scores (z-AMH) adjusted for gestational week at blood sampling were categorised in the 1st, 2nd-4th (reference), and 5th quintile...
August 14, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28843783/what-are-the-likely-ivf-icsi-outcomes-if-there-is-a-discrepancy-between-serum-amh-and-fsh-levels-a-multicenter-retrospective-study
#12
F Daney de Marcillac, A Pinton, A Guillaume, P Sagot, O Pirrello, C Rongieres
OBJECTIVE: The principal outcome was to assess the ovarian response to controlled hyperstimulation during in vitro fertilization (IVF) with or without micro-injection (ICSI) in patients whom ovarian reserve testing revealed a discrepancy between the serum levels of FSH and AMH. The secondary outcome was to determine whether AMH and FSH profiles could predict the IVF/ICSI response. STUDY DESIGN: This was a multicenter, retrospective study analysing all controlled ovarian hyperstimulation cycles with attempted fresh embryo transfer(s) carried out during IVF/ICSI treatment and in which the AMH level had been assayed between January 01, 2008 and December 31, 2011...
August 24, 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/28837250/a-phase-1-study-of-veliparib-with-carboplatin-and-weekly-paclitaxel-in-japanese-patients-with-newly-diagnosed-ovarian-cancer
#13
Shin Nishio, Munetaka Takekuma, Satoshi Takeuchi, Kouichirou Kawano, Naotake Tsuda, Kazuto Tasaki, Nobutaka Takahashi, Masakazu Abe, Aki Tanaka, Takayuki Nagasawa, Tadahiro Shoji, Hao Xiong, Silpa Nuthalapati, Terri Leahy, Hideyuki Hashiba, Tsukasa Kiriyama, Philip Komarnitsky, Yasuyuki Hirashima, Kimio Ushijima
This phase 1, open-label, dose-escalation study was conducted to determine the safety, tolerability, pharmacokinetics, and preliminary efficacy of veliparib with carboplatin and weekly paclitaxel in Japanese women with newly diagnosed, advanced ovarian cancer. Patients received veliparib at 100 or 150 mg twice daily on days 1-21 with carboplatin (area under the concentration-time curve 6 mg/mL•min) on day 1 and paclitaxel 80 mg/m(2) on days 1, 8, and 15 every 3 weeks for up to 6 21-day cycles. Dose escalation followed a 3+3 design to determine dose-limiting toxicities, maximum tolerated dose, and the recommended phase 2 dose...
August 24, 2017: Cancer Science
https://www.readbyqxmd.com/read/28833087/menstrual-pain-and-risk-of-epithelial-ovarian-cancer-results-from-the-ovarian-cancer-association-consortium
#14
Ana Babic, Holly R Harris, Allison F Vitonis, Linda J Titus, Susan J Jordan, Penelope M Webb, Harvey A Risch, Mary Anne Rossing, Jennifer A Doherty, Kristine Wicklund, Marc T Goodman, Francesmary Modugno, Kirsten B Moysich, Roberta Ness, Susanne K Kjaer, Joellen Schildkraut, Andrew Berchuck, Celeste L Pearce, Anna H Wu, Daniel W Cramer, Kathryn L Terry
Menstrual pain, a common gynecological condition, has been associated with increased risk of ovarian cancer in some, but not all studies. Furthermore, potential variations in the association between menstrual pain and ovarian cancer by histologic subtype have not been adequately evaluated due to lack of power. We assessed menstrual pain using either direct questions about having experienced menstrual pain, or indirect questions about menstrual pain as indication for use of hormones or medications. We used multivariate logistic regression to calculate the odds ratio (OR) for the association between severe menstrual pain and ovarian cancer, adjusting for potential confounders, and multinomial logistic regression to calculate odds ratios for specific histologic subtypes...
August 22, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28822715/reproductive-outcomes-of-segmented-in-vitro-fertilization-in-patients-diagnosed-with-endometriomas
#15
Kemal Ozgur, Hasan Bulut, Murat Berkkanoglu, Kevin Coetzee
STUDY OBJECTIVE: To assess the impact of ovarian endometriomas on endometrial receptivity in frozen embryo transfers (FET) of segmented in vitro fertilization (IVF) cycles. DESIGN: Retrospective, matched-control study (Canadian Task Force Classification II-2). SETTING: A single, private assisted reproductive technology center. PATIENTS: Thirty patients diagnosed with unilateral or bilateral endometrioma were compared with 60 patients without endometrioma from 1,894 patients who underwent segmented IVF treatment between September 2014 and September 2016...
August 16, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28820416/-ovarian-reserve-and-effectiveness-of-ivf-in-women-of-various-age-groups
#16
A Sayadyan, E Totoyan
The purpose of this study is a comparative assessment of ovarian reserve parameters and the effect of these indices on the features of follicle and oogenesis in women of different age groups. A retrospective analysis of IVF results was conducted in 101 patients aged 21 to 49 years. All patients were divided into 4 groups according to age: I group up to 30 y.o. - 45 women, II group - 31-35 y.o - 14 women, III group - 36-40 y.o. - 26 women, IV Group - 41 or more - 16 women. A low ovarian reserve was found in the majority (84,6%) of women in group III and in all women in group IV...
July 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28815572/risk-of-second-primary-cancers-in-women-diagnosed-with-endometrial-cancer-in-german-and-swedish-cancer-registries
#17
Tianhui Chen, Hermann Brenner, Mahdi Fallah, Lina Jansen, Felipe A Castro, Karla Geiss, Bernd Holleczek, Alexander Katalinic, Sabine Luttmann, Kristina Sundquist, Meike Ressing, Leiting Xu, Kari Hemminki
Along with the increasing incidence and favorable prognosis, more women diagnosed with endometrial cancer may develop second primary cancers (SPCs). We aimed at investigating risk of SPCs after endometrial cancer in Germany and Sweden to provide insight into prevention strategies for SPCs. Endometrial cancer patients diagnosed at age ≥15 years in Germany during 1997-2011 and in Sweden nationwide during 1997-2012 were selected. Standardized incidence ratios (SIRs), calculated as the ratio of observed to expected numbers of cases, were used to assess the risk of a specific second cancer after endometrial cancer for both German and Swedish datasets...
August 17, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28815550/fertility-preservation-in-women-with-borderline-ovarian-tumors-how-does-it-impact-disease-outcome-a-cohort-study
#18
Limor Helpman, Assaf Yaniv, Mario E Beiner, Sarit Aviel-Ronen, Tamar Perri, Gilad Ben-Baruch, Liat Hogen Ben-David, Ariella Jakobson-Setton, Jacob Korach
INTRODUCTION: Borderline ovarian tumors are typically indolent neoplasms. Since many are diagnosed in younger women, fertility conservation is an important consideration and has been advocated based on retrospective data. The objective of this study was to identify features impacting on recurrence and survival in a series of borderline ovarian tumors, and to assess the safety of a fertility-sparing approach. MATERIAL AND METHODS: A historical cohort study of consecutive borderline ovarian tumors cases treated at a single institution over 30 years (1981-2011)...
August 16, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28814333/rapamycin-prevents-cyclophosphamide-induced-over-activation-of-primordial-follicle-pool-through-pi3k-akt-mtor-signaling-pathway-in-vivo
#19
Linyan Zhou, Yanqiu Xie, Song Li, Yihua Liang, Qi Qiu, Haiyan Lin, Qingxue Zhang
BACKGROUND: Primordial follicular depletion has thought to be a common adverse effect of chemotherapy especially for female of reproductive age. The study aimed to evaluate the protective effect of rapamycin on the primordial follicles and its potential mechanism for patients receiving chemotherapy. METHODS: 8-week old BALB/c female mice were randomly assigned into four groups (control; rapamycin; cyclophosphamide; and rapamycin combined with cyclophosphamide). Hematoxylin staining, immunohistochemical, TUNEL, western blotting and ELISA were employed to assess inter-group differences using Student's t-test and Mann-Whitney test...
August 16, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28814191/maternal-overweight-disrupts-the-sexual-maturation-of-the-offspring
#20
Rocío A Galarza, Eric A Rhon Calderón, Analía E Cortez, Alicia G Faletti
The aims of the present work were to study the effect of maternal overweight and obesity on the ovarian reserve, follicular development, and ovulation of the offspring and to assess whether this maternal condition alters oocyte integrity. To this end, female offspring from rats fed standard (OSD) or cafeteria (OCD) diet were used. Body weight, vaginal opening, and estrous cycle were recorded and ovaries were obtained on the day of the second estrus. In addition, ovarian weight, ovulation rate (measured by the number of oocytes within oviducts), follicular development (determined by histology), and oocyte integrity were examined...
September 2017: Reproductive Sciences
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