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Ovarian reserve assessment

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https://www.readbyqxmd.com/read/29143969/the-molecular-basis-of-cytotoxicity-of-%C3%AE-spinasterol-from-ganoderma-resinaceum-induction-of-apoptosis-and-overexpression-of-p53-in-breast-and-ovarian-cancer-cell-lines
#1
Nada K Sedky, Zaynab El Gammal, Amir E Wahba, Eman Mosad, Zahraa Y Waly, Amira Ali El-Fallal, Reem K Arafa, Nagwa El-Badri
OBJECTIVES: Despite advances in therapy of breast and ovarian cancers, they still remain among the most imperative causes of cancer death in women. The first can be considered one of the most widespread diseases among females, while the latter is more lethal and needs prompt treatment. Thus, the research field can still benefit from discovery of new compounds that can be of potential use in management of these grave illnesses. We hereby aimed to assess the antitumor activity of the phytosterol α-spinasterol isolated from Ganoderma resinaceum mushroom on human breast cancer cell lines (MCF-7, MDA-MB-231), as well as, on human ovarian cancer cell line (SKOV-3)...
November 16, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29125883/a-genetic-variant-of-mir-335-binding-site-in-the-erbb4-3-utr-is-associated-with-prognosis-of-ovary-cancer
#2
Ping Wei, Ling Li, Zhihu Zhang, Wei Zhang, Ming Liu, Xiugui Sheng
BACKGROUND: Ovarian cancer is one of the leading gynecologic malignancies globally, the 5-year survival rate for patients with advanced stage ovarian cancer is very low. Our objective was to test the hypothesis that miR-335 was associated with the survival of patients with ovarian cancer. METHOD: Bioinformatics tools and luciferase report assay were used to select the target of miR-335, and real-time PCR was used to detect the expression of miR-335 and ERBB4 in different genotype groups...
November 10, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29121350/individualized-fsh-dosing-based-on-ovarian-reserve-testing-in-women-starting-ivf-icsi-a-multicentre-trial-and-cost-effectiveness-analysis
#3
Theodora C van Tilborg, Simone C Oudshoorn, Marinus J C Eijkemans, Monique H Mochtar, Ron J T van Golde, Annemieke Hoek, Walter K H Kuchenbecker, Kathrin Fleischer, Jan Peter de Bruin, Henk Groen, Madelon van Wely, Cornelis B Lambalk, Joop S E Laven, Ben Willem J Mol, Frank J M Broekmans, Helen L Torrance
STUDY QUESTION: Is there a difference in live birth rate and/or cost-effectiveness between antral follicle count (AFC)-based individualized FSH dosing or standard FSH dosing in women starting IVF or ICSI treatment? SUMMARY ANSWER: In women initiating IVF/ICSI, AFC-based individualized FSH dosing does not improve live birth rates or reduce costs as compared to a standard FSH dose. WHAT IS KNOWN ALREADY: In IVF or ICSI, ovarian reserve testing is often used to adjust the FSH dose in order to normalize ovarian response and optimize live birth rates...
November 7, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29121326/individualized-versus-standard-fsh-dosing-in-women-starting-ivf-icsi-an-rct-part-1-the-predicted-poor-responder
#4
Theodora C van Tilborg, Helen L Torrance, Simone C Oudshoorn, Marinus J C Eijkemans, Carolien A M Koks, Harold R Verhoeve, Annemiek W Nap, Gabrielle J Scheffer, A Petra Manger, Benedictus C Schoot, Alexander V Sluijmer, Arie Verhoeff, Henk Groen, Joop S E Laven, Ben Willem J Mol, Frank J M Broekmans
STUDY QUESTION: Does an increased FSH dose result in higher cumulative live birth rates in women with a predicted poor ovarian response, apparent from a low antral follicle count (AFC), scheduled for IVF or ICSI? SUMMARY ANSWER: In women with a predicted poor ovarian response (AFC < 11) undergoing IVF/ICSI, an increased FSH dose (225/450 IU/day) does not improve cumulative live birth rates as compared to a standard dose (150 IU/day). WHAT IS KNOWN ALREADY: In women scheduled for IVF/ICSI, an ovarian reserve test (ORT) can predict ovarian response to stimulation...
November 7, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29121269/individualized-versus-standard-fsh-dosing-in-women-starting-ivf-icsi-an-rct-part-2-the-predicted-hyper-responder
#5
Simone C Oudshoorn, Theodora C van Tilborg, Marinus J C Eijkemans, G Jur E Oosterhuis, Jaap Friederich, Marcel H A van Hooff, Evert J P van Santbrink, Egbert A Brinkhuis, Jesper M J Smeenk, Janet Kwee, Corry H de Koning, Henk Groen, Cornelis B Lambalk, Ben Willem J Mol, Frank J M Broekmans, Helen L Torrance
STUDY QUESTION: Does a reduced FSH dose in women with a predicted hyper response, apparent from a high antral follicle count (AFC), who are scheduled for IVF/ICSI lead to a different outcome with respect to cumulative live birth rate and safety? SUMMARY ANSWER: Although in women with a predicted hyper response (AFC > 15) undergoing IVF/ICSI a reduced FSH dose (100 IU per day) results in similar cumulative live birth rates and a lower occurrence of any grade of ovarian hyperstimulation syndrome (OHSS) as compared to a standard dose (150 IU/day), a higher first cycle cancellation rate and similar severe OHSS rate were observed...
November 7, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29098533/follicle-activation-is-a-significant-and-immediate-cause-of-follicle-loss-after-ovarian-tissue-transplantation
#6
Zohar Gavish, Itay Spector, Gil Peer, Stefan Schlatt, Joachim Wistuba, Hadassa Roness, Dror Meirow
PURPOSE: Extensive follicle loss has been demonstrated in ovarian grafts post transplantation, reducing their productivity and lifespan. Several mechanisms for this loss have been proposed, and this study aims to clarify when and how the massive follicle loss associated with transplantation of ovarian tissue graft occurs. An understanding of the mechanisms of follicle loss will pinpoint potential new targets for optimization and improvement of this important fertility preservation technique...
November 3, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29063502/arabian-peninsula-ethnicity-is-associated-with-lower-ovarian-reserve-and-ovarian-response-in-women-undergoing-fresh-icsi-cycles
#7
Aya M Tabbalat, Nigel Pereira, Devon Klauck, Clara Melhem, Rony T Elias, Zev Rosenwaks
PURPOSE: Recent studies have demonstrated that ethnicity can be an independent determinant of assisted reproductive technology (ART) outcomes. In this context, we investigate whether ART outcomes differ between Arabian Peninsula and Caucasian women. METHODS: This is a retrospective cohort study of women undergoing fresh intracytoplasmic sperm injection (ICSI)-embryo transfer (ET) cycles for male factor infertility. The study cohort was divided into 2 groups based on ethnicity-Arabian Peninsula or Caucasian...
October 23, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29055130/randomized-trial-of-combined-cabergoline-and-coasting-in-preventing-ovarian-hyperstimulation-syndrome-during-in-vitro-fertilization-intracytoplasmic-sperm-injection-cycles
#8
Yasmin A Bassiouny, Dina M R Dakhly, Yomna A Bayoumi, Noha M Salaheldin, Hisham M Gouda, Ayman A Hassan
OBJECTIVE: To assess the efficacy of coasting alone, cabergoline alone, or combining both interventions for preventing ovarian hyperstimulation syndrome (OHSS) among high-risk patients undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment cycles. METHODS: The present randomized controlled trial was conducted at the IVF unit of a university hospital in Cairo between October 28, 2013, and July 31, 2015. Patients undergoing IVF/ICSI considered at risk of OHSS were randomly allocated to coasting, cabergoline, or combined coasting and cabergoline...
October 21, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29055060/gonadotropin-releasing-hormone-agonists-for-ovarian-protection-during-cancer-chemotherapy-systematic-review-and-meta-analysis
#9
REVIEW
Janaina C Senra, Matheus Roque, Mariza C T Talim, Fernando M Reis, Rubens L C Tavares
OBJECTIVE: To evaluate the effectiveness of GnRH agonist (GnRHa) administration before and/or during cancer chemotherapy for the protection of ovarian reserve in premenopausal women. METHODS: We conducted a systematic review and meta-analysis of randomized controlled trials (RCT) comparing the use of GnRHa, before and/or during chemotherapy, vs. chemotherapy alone. Eligible participants were premenopausal women at any stage of cancer, without previous diagnosis of infertility...
October 21, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29049585/association-between-biomarkers-of-ovarian-reserve-and-infertility-among-older-women-of-reproductive-age
#10
Anne Z Steiner, David Pritchard, Frank Z Stanczyk, James S Kesner, Juliana W Meadows, Amy H Herring, Donna D Baird
Importance: Despite lack of evidence of their utility, biomarkers of ovarian reserve are being promoted as potential markers of reproductive potential. Objective: To determine the associations between biomarkers of ovarian reserve and reproductive potential among women of late reproductive age. Design, Setting, and Participants: Prospective time-to-pregnancy cohort study (2008 to date of last follow-up in March 2016) of women (N = 981) aged 30 to 44 years without a history of infertility who had been trying to conceive for 3 months or less, recruited from the community in the Raleigh-Durham, North Carolina, area...
October 10, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29048754/randomized-controlled-trial-of-the-effect-of-endometrial-injury-on-implantation-and-clinical-pregnancy-rates-during-the-first-icsi-cycle
#11
Ahmed M Maged, Hamsa Rashwan, Suzy AbdelAziz, Wafaa Ramadan, Walaa Ai Mostafa, Ahmed A Metwally, Maha Katta
OBJECTIVE: To assess whether endometrial injury in the cycle preceding controlled ovarian hyperstimulation during intracytoplasmic sperm injection (ICSI) improves the implantation and pregnancy rates. METHODS: Between January 1, 2016, and March 31, 2017, a randomized controlled trial was conducted at a center in Egypt among 300 women who met inclusion criteria (first ICSI cycle, aged <40 years, day-3 follicle-stimulating hormone <10 IU/L, normal serum prolactin, no uterine cavity abnormality)...
October 19, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29040513/targeted-metabolomics-reveals-reduced-levels-of-polyunsaturated-choline-plasmalogens-and-a-smaller-dimethylarginine-arginine-ratio-in-the-follicular-fluid-of-patients-with-a-diminished-ovarian-reserve
#12
J M Chao de la Barca, T Boueilh, G Simard, L Boucret, V Ferré-L'Hotellier, L Tessier, C Gadras, P E Bouet, P Descamps, V Procaccio, P Reynier, P May-Panloup
STUDY QUESTION: Does the metabolomic profile of the follicular fluid (FF) of patients with a diminished ovarian reserve (DOR) differ from that of patients with a normal ovarian reserve (NOR)? SUMMARY ANSWER: The metabolomic signature of the FF reveals a significant decrease in polyunsaturated choline plasmalogens and methyl arginine transferase activity in DOR patients compared to NOR patients. WHAT IS KNOWN ALREADY: The composition of the FF reflects the exchanges between the oocyte and its microenvironment during its acquisition of gametic competence...
November 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29040417/neonatal-immune-activation-depletes-the-ovarian-follicle-reserve-and-alters-ovarian-acute-inflammatory-mediators-in-neonatal-rats
#13
Erin A Fuller, Luba Sominsky, Jessie M Sutherland, Kate A Redgrove, Lauren Harms, Eileen A McLaughlin, Deborah M Hodgson
Normal ovarian development is crucial for female reproductive success and longevity. Interruptions to the delicate process of initial folliculogenesis may lead to ovarian dysfunction. We have previously demonstrated that an early life immune challenge in the rat, induced by administration of lipopolysaccharide (LPS) on postnatal day (PND) 3 and 5, depletes ovarian follicle reserve long term. Here, we hypothesised that this neonatal immune challenge leads to an increase in peripheral and ovarian inflammatory signalling, contributing to an acute depletion of ovarian follicles...
October 10, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29028285/trends-in-the-incidence-rate-type-and-treatment-of-surgically-verified-endometriosis-a-nationwide-cohort-study
#14
Liisu Saavalainen, Tuulia Tikka, Anna But, Mika Gissler, Jari Haukka, Aila Tiitinen, Päivi Härkki, Oskari Heikinheimo
To study the trends in incidence rate, type and surgical treatment, and patient characteristics of surgically verified endometriosis during 1987-2012 MATERIAL AND METHODS: This is a register-based cohort study. We identified women receiving their first diagnosis of endometriosis in surgery from the Finnish Hospital Discharge Register (FHDR). Quality of the FHDR records was assessed bidirectionally. The age-standardized incidence rates of the first surgically verified endometriosis was assessed by calendar year RESULTS: The cohort comprises 49 956 women...
October 13, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28993395/single-centre-retrospective-analysis-of-growth-hormone-supplementation-in-ivf-patients-classified-as-poor-prognosis
#15
Kevin N Keane, John L Yovich, Anahita Hamidi, Peter M Hinchliffe, Satvinder S Dhaliwal
BACKGROUND: Patients undergoing in vitro fertilisation (IVF) receive various adjuvant therapies in order to enhance success rates, but the true benefit is actively debated. Growth hormone (GH) supplementation was assessed in poor-prognosis women undergoing fresh IVF transfer cycles. METHODS: Data were retrospectively analysed from 400 IVF cycles, where 161 women received GH and 239 did not. RESULTS: Clinical pregnancy, live birth rates and corresponding ORs and CIs were significantly greater with GH, despite patients being significantly older with lower ovarian reserve...
October 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/28955058/predictive-accuracy-of-anti-mullerian-hormone-as-indicator-of-ovarian-follicle-loss-in-cyclophosphamide-treated-mice
#16
Zehra Jamil, Khalida Perveen, Rabia Malik, Lubna Avesi
OBJECTIVE: To evaluate the strength of anti-mullerian hormone in reflecting the stages of ovarian toxicity-induced by cyclophosphamide. METHODS: This study was conducted in December 2014 and comprised female mice that were divided into four groups: group A served as control, group B received three weekly injections of cyclophosphamide, group C was co administered alpha-tocopherol along with cyclophosphamide, while group D solely received alpha-tocopherol. The ovaries were evaluated for follicular dynamics, and anti-mullerian hormone was assessed using mouse enzyme-linked immunosorbent assay kit...
October 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28938736/deep-sequencing-shows-that-oocytes-are-not-prone-to-accumulate-mtdna-heteroplasmic-mutations-during-ovarian-ageing
#17
L Boucret, C Bris, V Seegers, D Goudenège, V Desquiret-Dumas, M Domin-Bernhard, V Ferré-L'Hotellier, P E Bouet, P Descamps, P Reynier, V Procaccio, P May-Panloup
STUDY QUESTION: Does ovarian ageing increase the number of heteroplasmic mitochondrial DNA (mtDNA) point mutations in oocytes? SUMMARY ANSWER: Our results suggest that oocytes are not subject to the accumulation of mtDNA point mutations during ovarian ageing. WHAT IS KNOWN ALREADY: Ageing is associated with the alteration of mtDNA integrity in various tissues. Primary oocytes, present in the ovary since embryonic life, may accumulate mtDNA mutations during the process of ovarian ageing...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28934714/efficacy-of-dehydroepiandrosterone-dhea-to-overcome-the-effect-of-ovarian-ageing-ditto-a-proof-of-principle-double-blinded-randomized-placebo-controlled-trial
#18
Amarin Narkwichean, Walid Maalouf, Miriam Baumgarten, Lukasz Polanski, Nick Raine-Fenning, Bruce Campbell, Kannamannadiar Jayaprakasan
OBJECTIVE: To evaluate the effect of DHEA supplementation on In-Vitro Fertilisation (IVF) outcome as assessed by ovarian response, oocyte developmental competence and live birth rates in women predicted to have poor ovarian reserve (OR). The feasibility of conducting a large trial is also assessed by evaluating the recruitment rates and compliance of the recruited participants with DHEA/placebo intake and follow-up rates. STUDY DESIGN: A single centre, double blinded, placebo controlled, randomized trial was performed over two years with 60 women undergoing in-vitro fertilisation (IVF)...
November 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28914967/chemotherapy-response-score-is-a-useful-histological-predictor-of-prognosis-in-high-grade-serous-carcinoma
#19
Authors Priya Singh, Vikrant Kaushal, Bhavana Rai, Arvind Rajwanshi, Nalini Gupta, Pranab Dey, Rashi Garg, Manish Rohilla, Vanita Suri, Sushmita Ghoshal, Radhika Srinivasan
AIM: High grade serous carcinoma (HGSC) is the most common tubal/ovarian malignant tumor usually presenting in advance stage. Interval debulking surgery (IDS) post neoadjuvant chemotherapy (NACT) has been increasingly in use for the management of these patients. Chemotherapy response score (CRS) has been proposed for grading response of tubo-ovarian HGSC to NACT on the basis of examination of IDS specimens. Our aim was to evaluate CRS in post NACT cases, assess the interobserver agreement and correlate it to overall and progression- free survival...
September 15, 2017: Histopathology
https://www.readbyqxmd.com/read/28911998/establishing-age-specific-reference-intervals-for-anti-m%C3%A3-llerian-hormone-in-adult-chinese-women-based-on-a-multicenter-population
#20
Xinqi Cheng, Qiong Zhang, Min Liu, Shijun Li, Zhihua Tao, Kiyoshi Ichihara, Songlin Yu, Kai Zhang, Pengchang Li, Jianhua Han, Ling Qiu
AIM OF THIS STUDY: Anti-Müllerian hormone (AMH) is useful for the assessment of ovarian reserve and treatment of individualized in vitro fertilization (IVF). The aim of this study is to establish AMH reference interval for adult Chinese women on the Beckman Beckman DxI 800 platform. MATERIAL AND METHODS: From May to September 2013, serum from 1169 apparently healthy adult females from five representative cities in China (Beijing, Hangzhou, Guangzhou, Dalian and Urumqi) were collected, and AMH was analyzed on the platform of Beckman DxI 800 automated chemiluminescence immunoassay...
November 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
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