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Ovarian reserve assessment

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https://www.readbyqxmd.com/read/27907901/serum-amh-levels-in-healthy-women-from-brca1-2-mutated-families-are-they-reduced
#1
Theodora C van Tilborg, Inge A P Derks-Smeets, Anna M E Bos, Jan C Oosterwijk, Ron J van Golde, Christine E de Die-Smulders, Lizet E van der Kolk, Wendy A G van Zelst-Stams, Maria E Velthuizen, Annemieke Hoek, Marinus J C Eijkemans, Joop S E Laven, Margreet G E M Ausems, Frank J M Broekmans
STUDY QUESTION: Do BRCA1/2 mutation carriers have a compromised ovarian reserve compared to proven non-carriers, based on serum anti-Müllerian hormone (AMH) levels? SUMMARY ANSWER: BRCA1/2 mutation carriers do not show a lower serum AMH level in comparison to proven non-carriers, after adjustment for potential confounders. WHAT IS KNOWN ALREADY: It has been suggested that the BRCA genes play a role in the process of ovarian reserve depletion, although previous studies have shown inconsistent results regarding the association between serum AMH levels and BRCA mutation status...
November 2016: Human Reproduction
https://www.readbyqxmd.com/read/27906603/utility-of-ovarian-reserve-screening-with-anti-m%C3%A3-llerian-hormone-for-reproductive-age-women-deferring-pregnancy
#2
Lisa C Grossman, Lauren Zakarin Safier, Melissa D Kline, Cariann W Chan, Rogerio A Lobo, Mark V Sauer, Nataki C Douglas
BACKGROUND: Ovarian reserve (OR) testing with serum anti-Müllerian hormone (AMH) can provide information about a woman's fertility potential. The aim of this study was to assess interest and knowledge about OR testing and investigate the utility of measuring AMH in women of reproductive age deferring pregnancy. METHODS: Women ages 27-37 years currently delaying childbearing were invited to take a survey regarding attitudes and knowledge about OR testing before and after an AMH measurement with explanation of their results...
December 1, 2016: Journal of Women's Health
https://www.readbyqxmd.com/read/27894151/value-of-the-ultrasound-in-the-study-of-ovarian-reserve-for-prediction-of-oocyte-recovery
#3
Meire Spressão, Antonio Hélio Oliani, Denise Cristina Mós Vaz Oliani
Purpose To identify which methods used in the assessment of the ovarian reserve are exclusive or complementary to identify the best response to follicle development. Methods Retrospective cohort study, involving patients undergoing assisted reproduction treatment at the Instituto de Medicina Reprodutiva e Fetal, from April 2009 to July 2014. Age, biochemical tests, and ultrasound were assessed. The data were analyzed to predict the follicular development and the relation between them, using, for statistical analysis, Statistical Package for Social Sciences software...
October 2016: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/27855763/-fertility-screening-is-a-new-concept
#4
Kathrine Birch Petersen, Anders Nyboe Andersen
The Fertility Assessment and Counselling Clinic was initiated in 2011 as an analogue to the family planning clinics in the 1970s, but with a pro-fertility aim. The idea was to provide individual assessment of fertility risk factors, ovarian reserve and sperm concentration to help women and men to fulfil their reproductive life plan. Fertility screening on an individual level is a new concept, and the Fertility Assessment and Counselling Clinic is the first of its kind. The aim of the clinic is to reduce the need for fertility treatments and to prevent involuntary childlessness...
November 14, 2016: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/27842995/antim%C3%A3-llerian-hormone-levels-and-cardiometabolic-risk-in-young-women-with-polycystic-ovary-syndrome
#5
Rebecca A Feldman, Kathleen O'Neill, Samantha F Butts, Anuja Dokras
OBJECTIVE: To determine the association between antimüllerian hormone (AMH) levels and metabolic syndrome (MetSyn) in young women with polycystic ovary syndrome (PCOS). DESIGN: Cross-sectional study. SETTING: Academic PCOS center. PATIENT(S): A total of 252 women aged 18-46 years with PCOS. INTERVENTION: None. MAIN OUTCOME MEASURE(S): Association of AMH with markers of cardiometabolic risk and MetSyn...
November 11, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27809927/salpingectomy-before-assisted-reproductive-technologies-a-systematic-literature-review
#6
REVIEW
Marco Noventa, Salvatore Gizzo, Carlo Saccardi, Shara Borgato, Amerigo Vitagliano, Michela Quaranta, Pietro Litta, Michele Gangemi, Guido Ambrosini, Donato D'Antona, Stefano Palomba
Salpingectomy is largely used in case of hydrosalpinx in infertile women scheduled for assisted reproductive technologies (ART), whereas there is no consensus on its role in absence of hydrosalpinx. The current is a systematic literature review to collate all available evidence regarding salpingectomy as fertility enhancement procedure before ART in infertile patients. Our primary endpoint was to assess the impact of the surgical procedure on ovarian reserve, and secondary outcomes were to evaluate its benefits and harms on ART outcomes...
November 3, 2016: Journal of Ovarian Research
https://www.readbyqxmd.com/read/27793768/cognitive-changes-across-the-menopause-transition-a-longitudinal-evaluation-of-the-impact-of-age-and-ovarian-status-on-spatial-memory
#7
Stephanie V Koebele, Sarah E Mennenga, Ryoko Hiroi, Alicia M Quihuis, Lauren T Hewitt, Mallori L Poisson, Christina George, Loretta P Mayer, Cheryl A Dyer, Leona S Aiken, Laurence M Demers, Catherine Carson, Heather A Bimonte-Nelson
Cognitive changes that occur during mid-life and beyond are linked to both aging and the menopause transition. Studies in women suggest that the age at menopause onset can impact cognitive status later in life; yet, little is known about memory changes that occur during the transitional period to the postmenopausal state. The 4-vinylcyclohexene diepoxide (VCD) model simulates transitional menopause in rodents by depleting the immature ovarian follicle reserve and allowing animals to retain their follicle-deplete ovarian tissue, resulting in a profile similar to the majority of perimenopausal women...
October 26, 2016: Hormones and Behavior
https://www.readbyqxmd.com/read/27793163/involvement-of-mesosalpinx-in-endometrioma-is-a-possible-risk-factor-for-decrease-of-ovarian-reserve-after-cystectomy-a-retrospective-cohort-study
#8
Ai Saito, Akira Iwase, Tomoko Nakamura, Satoko Osuka, Bayasula, Tomohiko Murase, Nao Kato, Chiharu Ishida, Sachiko Takikawa, Maki Goto, Fumitaka Kikkawa
BACKGROUND: Serum anti-Müllerian hormone (AMH) concentration has been used to assess ovarian reserve in patients with endometriosis, especially when endometrioma surgery is involved. Previously, we reported that decreased serum AMH levels after cystectomy for endometriomas can recover to preoperative levels in some cases. In this present study, we assessed the sequential changes in serum AMH levels before and after cystectomy in terms of the state of the mesosalpinx prior to surgery...
October 28, 2016: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/27791958/one-year-in-review-2016-beh%C3%A3-et-s-syndrome
#9
REVIEW
Gulen Hatemi, Emire Seyahi, Izzet Fresko, Rosaria Talarico, Vedat Hamuryudan
Several articles highlighting the epidemiology, pathogenesis, clinical features, treatment modalities and disease assessment of Behçet's syndrome (BS) have been published during the last year. Clinical and radiological features of lower extremity deep vein thrombosis due to BS can be quite different than those found in thrombosis due to other causes; additionally, frequency of post-thrombotic syndrome is significantly increased in BS. Some clinical and colonoscopic features are useful in differentiating BS from Crohn's disease...
September 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27787477/assessment-of-ovarian-reserve-and-fertility-preservation-strategies-in-children-treated-for-cancer
#10
Laura Guzy, Isabelle Demeestere
INTRODUCTION: The survival rate of chemotherapy treatments of malignant cancer or non- malignant conditions are continuously improving. As a result, there is an increased number of patients who received a gonadotoxic treatment during childhood and who later face fertility issues. Depending on the extent of the damage to the ovaries, acute or late complications may occur. Acute ovarian failure is defined by permanent amenorrhea after a high-risk treatment. When the drugs used are less gonadotoxic, ovarian insufficiency might appear later...
October 27, 2016: Minerva Ginecologica
https://www.readbyqxmd.com/read/27767231/novel-brca1-and-brca2-tumor-test-as-basis-for-treatment-decisions-and-referral-for-genetic-counselling-of-patients-with-ovarian-carcinomas
#11
Robbert D A Weren, Arjen R Mensenkamp, Michiel Simons, Astrid Eijkelenboom, Aisha S Sie, Hicham Ouchene, Monique van Asseldonk, Encarna B Gomez-Garcia, Marinus J Blok, Joanne A de Hullu, Marcel R Nelen, Alexander Hoischen, Johan Bulten, Bastiaan B J Tops, Nicoline Hoogerbrugge, Marjolijn J L Ligtenberg
With the recent introduction of Poly(ADP-ribose) polymerase inhibitors, a promising novel therapy has become available for ovarian carcinoma (OC) patients with inactivating BRCA1 or BRCA2 mutations in their tumor. To select patients who may benefit from these treatments, assessment of the mutation status of BRCA1 and BRCA2 in the tumor is required. For reliable evaluation of germline and somatic mutations in these genes in DNA derived from formalin-fixed, paraffin-embedded (FFPE) tissue, we have developed a single-molecule molecular inversion probe (smMIP)-based targeted next-generation sequencing (NGS) approach...
October 21, 2016: Human Mutation
https://www.readbyqxmd.com/read/27727481/dietary-inflammatory-index-and-risk-of-epithelial-ovarian-cancer-in-african-american-women
#12
Lauren C Peres, Elisa V Bandera, Bo Qin, Kristin A Guertin, Nitin Shivappa, James R Hebert, Sarah E Abbott, Anthony J Alberg, Jill Barnholtz-Sloan, Melissa Bondy, Michele L Cote, Ellen Funkhouser, Patricia G Moorman, Edward S Peters, Ann G Schwartz, Paul D Terry, Fabian Camacho, Frances Wang, Joellen M Schildkraut
Chronic inflammation has been implicated in the development of epithelial ovarian cancer (EOC); yet the contribution of inflammatory foods and nutrients to EOC risk has been understudied. We investigated the association between the dietary inflammatory index (DII), a novel literature-derived tool to assess the inflammatory potential of one's diet, and EOC risk in African American (AA) women in the African American Cancer Epidemiology Study, the largest population-based case-control study of EOC in AA women to date...
October 11, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27726984/biological-functions-and-clinical-applications-of-anti-m%C3%A3-llerian-hormone-in-stallions-and-mares
#13
REVIEW
Anthony N J Claes, Barry A Ball
Anti-Müllerian hormone (AMH) plays a major role in sexual differentiation, Leydig cell differentiation, and folliculogenesis. In addition, AMH has clinical value in equine practice. In stallions, AMH can serve as an endocrine marker for equine cryptorchidism and as an immunohistochemical marker for Sertoli cell tumors. Considering that AMH is also an ovarian specific product, intact mares can be differentiated from ovariectomized mares. Peripheral AMH concentrations reflect the follicular population in mares, and therefore, are useful in the assessment of ovarian reserve and reproductive life-span of aged mares...
December 2016: Veterinary Clinics of North America. Equine Practice
https://www.readbyqxmd.com/read/27716302/back-to-the-basics-of-ovarian-aging-a-population-based-study-on-longitudinal-anti-m%C3%A3-llerian-hormone-decline
#14
A C de Kat, Y T van der Schouw, M J C Eijkemans, G C Herber-Gast, J A Visser, W M M Verschuren, F J M Broekmans
BACKGROUND: Anti-Müllerian hormone (AMH) is currently used as an ovarian reserve marker for individualized fertility counseling, but very little is known of individual AMH decline in women. This study assessed whether the decline trajectory of AMH is uniform for all women, and whether baseline age-specific AMH levels remain consistently high or low during this trajectory. METHODS: A total of 3326 female participants from the population-based Doetinchem Cohort Study were followed with five visits over a 20-year period...
October 3, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27716277/array-cgh-diagnosis-in-ovarian-failure-identification-of-new-molecular-actors-for-ovarian-physiology
#15
Sylvie Jaillard, Linda Akloul, Marion Beaumont, Houda Hamdi-Roze, Christele Dubourg, Sylvie Odent, Solène Duros, Nathalie Dejucq-Rainsford, Marc-Antoine Belaud-Rotureau, Célia Ravel
BACKGROUND: Ovarian failure (OF) is considered premature if it occurs before the age of 40. This study investigates the genetic aetiology underlying OF in women under the age of 40 years. METHODS: We conducted an experimental prospective study performing all genome microarrays in 60 patients younger than 40 years presenting an OF revealed by a decrease of circulating Anti-Müllerian Hormone (AMH) and leading to an oocyte donation program. RESULTS: We identified nine significant copy number variations (CNVs) including candidate genes potentially implicated in reproductive function...
October 3, 2016: Journal of Ovarian Research
https://www.readbyqxmd.com/read/27697621/the-effects-of-uterine-artery-embolization-on-ovarian-reserve
#16
Chang-Woon Kim, Haeng Seon Shim, Hong Jang, Yun Gyu Song
OBJECTIVE: To evaluate the effects of UAE for symptomatic uterine fibroids on ovarian reserve based on AMH. STUDY DESIGN: This was a retrospective study conducted between March 2011 and October 2014. All women underwent UAE. At baseline and at the 3-month and 12-month follow-up visits, serum anti-Müllerian hormone (AMH), follicle stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2) levels were assessed, and ovarian volume and antral follicle count (AFC) were evaluated in each patient...
September 23, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27697140/individual-fertility-assessment-and-counselling-in-women-of-reproductive-age
#17
Kathrine Birch Petersen
The overall aim of this thesis was to validate the new concept of the Fertility Assessment and Counselling (FAC) Clinic at Rigshospitalet. The intention was to: explore the prognostic value of fertility risk factors by a risk score and provide an estimate of female fecundity, to quantify the impact of oral contraception (OC) on ovarian reserve parameters defined as Anti Müllerian Hormone (AMH), Antral Follicle Count (AFC) and ovarian volume, and to gain knowledge of attitudes and considerations toward family formation in women of advanced age...
October 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27689809/age-related-normogram-for-antral-follicle-count-in-general-population-and-comparison-with-previous-studies
#18
Gurkan Bozdag, Pinar Calis, Dila Zengin, Atakan Tanacan, Sevilay Karahan
OBJECTIVE: To construct antral follicle count (AFC) nomogram of general population for every age and to compare our data with previous studies to assess whether available AFC nomograms present any geographical inconsistency. STUDY DESIGN: A prospective cross-sectional study was conducted to document AFC nomogram among women in 20-50 years with regular menstrual bleeding. Patients admitted with hirsutism, menstrual irregularity, diagnosis of current/history of endometrioma and hormonal drug use within the last 6 months were excluded...
September 20, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27687487/individualised-fsh-dosing-and-ivf-outcome-in-agonist-downregulated-cycles-a-systematic-review
#19
Theodora C Van Tilborg, Frank J M Broekmans, Madeleine Dólleman, Marinus J C Eijkemans, Ben Willem Mol, Joop S E Laven, Helen L Torrance
INTRODUCTION: This systematic review examines whether individualised gonadotropin dosing in in-vitro fertilisation (IVF) leads to better outcomes with respect to safety, costs and live birth rates compared to standard dosing. MATERIAL AND METHODS: Electronic databases searched were PubMed, Embase and Cochrane. The primary outcome was live birth rate. The secondary outcomes included pregnancy rate, costs and safety. Papers were critically appraised by two reviewers...
September 30, 2016: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/27679824/analysis-of-ovarian-reserve-markers-amh-fsh-afc-in-different-age-strata-in-ivf-icsi-patients
#20
Ensieh Shahrokh Tehraninezhad, Fatemeh Mehrabi, Raheleh Taati, Vahid Kalantar, Elham Aziminekoo, Azam Tarafdari
BACKGROUND: The predictive roles of follicle stimulating hormone (FSH), anti-mullerian hormone (AMH) and antral follicle count (AFC) as ovarian reserve markers in women with different age groups are not established well. OBJECTIVE: This study compares the value of FSH, AMH and AFC at the time of in vitro fertilization (IVF) treatment in different age groups. MATERIALS AND METHODS: In this cross-sectional study, 103 women aged 20-43 years candidates for IVF/ICSI cycle were recruited...
August 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
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