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REVIEW
Martin Boersma
BACKGROUND: Intermittent exotropia is a common form of pediatric strabismus characterized by intermittent misalignment of the eyes. This study investigated the clinical effectiveness of alternating occlusion therapy as a non-surgical alternative for children aged 3-10 with intermittent exotropia. METHODS: A comprehensive review of recent research, including randomized controlled trials and case series, was conducted. These studies utilized standardized control scores to assess the impact of alternating occlusion therapy on both distance and near control of alignment...
April 22, 2024: Journal of Binocular Vision and Ocular Motility
#2
JOURNAL ARTICLE
Anoop Manjunath, Nathan Kahrobai, Mark A Lemley, Ishan Kumar
Competition between life science companies is critical to ensure innovative therapies are efficiently developed. Anticompetitive behavior may harm scientific progress and, ultimately, patients. One well-established category of anticompetitive behavior is the 'interlocking directorate'. It is illegal for companies' directors to 'interlock' by also serving on the boards of competitors. We evaluated overlaps in the board membership of 2,241 public life science companies since 2000. We show that a robust network of interlocking companies is present among these firms...
2024: Journal of Law and the Biosciences
#3
JOURNAL ARTICLE
Woranan Witthayapipopsakul, Shaheda Viriyathorn, Salisa Rittimanomai, Jan van der Meulen, Viroj Tangcharoensathien, Ipek Gurol-Urganci, Anne Mills
BACKGROUND: Various features in health insurance schemes may lead to variation in health care. Unwarranted variations raise concerns about suboptimal quality of care, differing treatments for similar needs, or unnecessary financial burdens on patients and health systems. This realist review aims to explore insurance features that may contribute to health care variation in Asian countries; and to understand influencing mechanisms and contexts. METHODS: We undertook a realist review...
February 17, 2024: International Journal of Health Policy and Management
#4
JOURNAL ARTICLE
Shrutangi Vaidya, Shubham Atal, Rajnish Joshi
Introduction Type 2 diabetes mellitus (T2DM) poses a substantial burden globally and particularly in India, affecting health, finances, and overall quality of life. The management of this condition relies on lifestyle modifications and advanced pharmacological interventions, with emerging drugs showing promise in areas such as administration, side effects, efficacy, and cardiovascular benefits. However, their market penetration is hindered by high costs. Understanding the target population's expectations and willingness to pay (WTP) for these drugs is crucial...
March 2024: Curēus
#5
REVIEW
Subho Chakrabarti
Low- and middle-income countries (LMICs) bear the greater share of the global mental health burden but are ill-equipped to deal with it because of severe resource constraints leading to a large treatment gap. The remote provision of mental health services by digital means can effectively augment conventional services in LMICs to reduce the treatment gap. Digital psychiatry in LMICs has always lagged behind high-income countries, but there have been encouraging developments in the last decade. There is increasing research on the efficacy of digital psychiatric interventions...
March 19, 2024: World Journal of Psychiatry
#6
JOURNAL ARTICLE
Shyamkumar Sriram, Muayad Albadrani
INTRODUCTION: High percentage of OOP (Out-of-Pocket) costs can lead to poverty and exacerbate existing poverty, with 21.9% of India's 1.324 billion people living below the poverty line. Factors such as increased patient cost-sharing, high-deductible health plans, and expensive medications contribute to high OOP costs. Understanding the poverty-inducing impact of healthcare payments is essential for formulating effective measures to alleviate it. METHODS: The study used data from the 75th round of the National Sample Survey Organization (Household Social Consumption in India: Health) from July 2017-June 2018, focusing on demographic-socio-economic characteristics, morbidity status, healthcare utilization, and expenditure...
2024: F1000Research
#7
JOURNAL ARTICLE
Muhammad Arif Mughal, Ata Ullah, Xinbo Yu, Wei He, N Z Jhanjhi, Sayan Kumar Ray
The Internet of Things (IoT) is a network of intelligent devices especially in healthcare-based systems. Internet of Medical Things (IoMT) uses wearable sensors to collect data and transmit to central repositories. The security and privacy of healthcare data is a challenging task. The aim of the study is to provide a secure data sharing mechanism. The existing studies provide secure data sharing schemes but still have limitations in terms of hiding the patient identify in the messages exchanged to upload the data on central repositories...
April 15, 2024: Heliyon
#8
JOURNAL ARTICLE
Jared H Sun, Shaheem de Vries, Nee-Kofi Mould-Millman
The World Health Organization recognized timely healthcare as a human right and called for the expansion of two-tiered prehospital and out-of-hospital emergency care systems in low- and middle-income countries. Tier-1 systems involve community-based first responder care, and Tier-2 systems involve more formalized emergency medical services designed as a sustainable system of services, including dedicated ambulances, personnel, and equipment. Tier-2 systems can play a crucial role in reducing mortality and disability due to emergency medical and surgical conditions worldwide...
April 10, 2024: Surgery
#9
JOURNAL ARTICLE
Rahul V C Tiwari, Sandesh K Sharma, Sujit R Sahoo, Srujan K Velthuru, Jeevan Matada Basavarajaiah, Madiha Kazi, Heena Dixit
BACKGROUND: In the Visakhapatnam District, this study compares the quality management procedures used by public and private hospitals. Knowing how these practices are similar and different from one another can help inform policy decisions and improve the quality of health care. MATERIALS AND METHODS: A cross-sectional study design was used, and 100 hospitals from both public (50 hospitals) and private (50 hospitals) were included in the sample size. A standardized questionnaire that evaluated different aspects of quality management practices was used to gather the data...
February 2024: Journal of Pharmacy & Bioallied Sciences
#10
JOURNAL ARTICLE
Bijetri Bose, Amy Raub, Aleta Sprague, Alfredo Martin, Pragya Bhuwania, Rachel Kidman, Jody Heymann
BACKGROUND: Antenatal care (ANC) is critical to reducing maternal and infant mortality. However, sub-Saharan Africa (SSA) continues to have among the lowest levels of ANC receipt globally, with half of mothers not meeting the WHO minimum recommendation of at least four visits. Increasing ANC coverage will require not only directly reducing geographic and financial barriers to care but also addressing the social determinants of health that shape access. Among those with the greatest potential for impact is maternal education: past research has documented a relationship between higher educational attainment and antenatal healthcare access, as well as related outcomes like health literacy and autonomy in health decision-making...
April 8, 2024: BMC Pregnancy and Childbirth
#11
REVIEW
Ruth Kieran, Maeve Hennessy, Kate Coakley, Hazel O'Sullivan, Tim Cronin, Daire Lynch, Eibhlin Mulroe, Katie Cooke, Dearbhaile Collins, Seamus O'Reilly
A combination of improvements in patient survival, increasing treatment duration, and the development of more expensive agents has led to a doubling of per-capita spending on cancer medicines in Ireland (2008-2018). Despite this, access to new drugs is poor in comparison to other EU countries. We examine methods to optimise oncology drug spending to facilitate access to newer anticancer agents. Key targets for spending optimisation (biosimilar use, clinical trials and expanded access programs, waste reduction, avoidance of futile treatment, and altered drug scheduling) were identified through an exploratory analysis...
April 3, 2024: Irish Journal of Medical Science
#12
JOURNAL ARTICLE
Waleed M Sweileh
RATIONALE: Patient-centred care has emerged as a transformative approach in managing chronic diseases, aiming to actively involve patients in their healthcare decisions. AIMS AND OBJECTIVES: This study was conducted to analyse and map the research landscape on patient-centred care in the context of chronic disease management. METHODS: This study used Scopus to retrieve the relevant articles. The analysis focused on the growth pattern, highly cited articles, randomised clinical trials, patients and providers perspectives, facilitators and barriers, frequent author keywords, emerging topics, and prolific countries and journals in the field...
April 3, 2024: Journal of Evaluation in Clinical Practice
#13
JOURNAL ARTICLE
Farbod Amirghasemi, Sina Khazaee Nejad, Ruitong Chen, Ali Soleimani, Victor Ong, Nika Shroff, Tanya Eftekhari, Kara Ushijima, Alar Ainla, Steven Siegel, Maral P S Mousavi
For the past 70 years, lithium has been used as a mood stabilizer for the treatment of bipolar disorder. The toxicity of lithium and its narrow therapeutic window has been known for decades. Close monitoring of lithium concentration in biofluids and adjustment of drug dosage can minimize the devastating side effects, such as permanent kidney and neurological damage. Despite this, we still do not have point-of-care tools that can accurately measure lithium levels in biofluids for frequent monitoring. This work presents LiFT (a lithium fiber-based test), the first low-cost electrochemical sensor that can measure lithium in human saliva and urine with FDA-required accuracy...
April 2, 2024: Advanced Healthcare Materials
#14
JOURNAL ARTICLE
Zhao Li, Wanzhi Shen, Tao Zhang
Focusing on the research scenario that integrates value-based healthcare objectives with the pharmaceutical group purchasing model, this study delineates value-based healthcare objectives in pharmaceutical group purchasing from three perspectives: drug sales price, drug quality, and service level. We construct a three-level pharmaceutical group purchasing supply chain consisting of drug manufacturers, medical institutions, and non-profit drug group purchasing organisations. Under centralised and decentralised decision-making, we introduce cost-sharing contracts and "cost-sharing-quantity-discount" contracts to analyse the impact of factors such as drug sales price, quality, and sensitivity of the service level...
April 15, 2024: Heliyon
#15
JOURNAL ARTICLE
Troy A Black, Mariya George, Morgan A Rousseau, Rashid M Rashid
Smartwatches have proven life-saving in medical specialties such as cardiology. Smartwatches actively warn us of arrhythmia risk and loud noise exposure. However, dermatologic health metrics are rarely monitored, and users are never alerted of potential skin health issues. Furthermore, the role of these devices within dermatology has not been evaluated in the literature. This study aims to analyze the current data points monitored by smartwatches and discuss potential adaptations to support dermatologic patient education and improve clinical management...
February 2024: Curēus
#16
MULTICENTER STUDY
Amir Reza Ashraf, Anna Somogyi-Végh, Sára Merczel, Nóra Gyimesi, András Fittler
BACKGROUND: Preventable patient harm, particularly medication errors, represent significant challenges in healthcare settings. Dispensing the wrong medication is often associated with mix-up of lookalike and soundalike drugs in high workload environments. Replacing manual dispensing with automated unit dose and medication dispensing systems to reduce medication errors is not always feasible in clinical facilities experiencing high patient turn-around or frequent dose changes. Artificial intelligence (AI) based pill recognition tools and smartphone applications could potentially aid healthcare workers in identifying pills in situations where more advanced dispensing systems are not implemented...
April 2024: Artificial Intelligence in Medicine
#17
JOURNAL ARTICLE
Manuel de Jesus Encarnacion Ramirez, Jeff Natalaja Mukengeshay, Gennady Chumtin, Renat Nurmukhametov, Matias Baldoncini, Jesus Lafuente, Andreina Rosario Rosario, Siddarth Kannan, Aderehime Haidara, Issael Ramirez, Ismail Bozkurt, Ignatius Esene, Stanislav Kaprovoy, Nikolay Konovalov, Kazadi Kelvin Kalangu, Gerald Musa, Michael T Lawton, Vishal K Chavda, Eric Suero Molina, Nicola Montemurro
INTRODUCTION: Neurosurgery is evolving with new techniques and technologies, relies heavily on high-quality education and training. Social networks like Twitter, Facebook, Instagram and LinkedIn have become integral to this training. These platforms enable sharing of surgical experiences, fostering global knowledge-sharing and collaboration among neurosurgeons. Virtual conferences and courses are accessible, enhancing learning regardless of location. While these networks offer real-time communication and collaborative opportunities, they also pose challenges like the spread of misinformation and potential distractions...
2024: Frontiers in Surgery
#18
JOURNAL ARTICLE
Richard Chiu, Eric Tatara, Mary Ellen Mackesy-Amiti, Kimberly Page, Jonathan Ozik, Basmattee Boodram, Harel Dahari, Alexander Gutfraind
Despite the availability of direct-acting antivirals that cure individuals infected with the hepatitis C virus (HCV), developing a vaccine is critically needed in achieving HCV elimination. HCV vaccine trials have been performed in populations with high incidence of new HCV infection such as people who inject drugs (PWID). Developing strategies of optimal recruitment of PWID for HCV vaccine trials could reduce sample size, follow-up costs and disparities in enrollment. We investigate trial recruitment informed by machine learning and evaluate a strategy for HCV vaccine trials termed PREDICTEE-Predictive Recruitment and Enrichment method balancing Demographics and Incidence for Clinical Trial Equity and Efficiency...
March 13, 2024: Healthcare (Basel, Switzerland)
#19
JOURNAL ARTICLE
Moses Ocan, Winnie Nambatya, Caroline Otike, Loyce Nakalembe, Sam Nsobya
BACKGROUND: Malaria remains one of the leading causes of morbidity, and mortality in Uganda. A large proportion of malaria symptomatic patients seek healthcare in private sector. However, availability and affordability are major barriers to access to effective treatment. The private sector copayment mechanism in Uganda aims to increase availability and affordability of antimalarial agents. Our study assessed availability, price, and market share of quality assured artemisinin-based combination therapies (QAACTs) in private drug outlets in selected districts during the implementation of copayment mechanism...
2024: PloS One
#20
JOURNAL ARTICLE
Alpha Oumar Diallo, Maja E Marcus, David Flood, Michaela Theilmann, Nicholas E Rahim, Alan Kinlaw, Nora Franceschini, Til Stürmer, Dessie V Tien, Mohsen Abbasi-Kangevari, Kokou Agoudavi, Glennis Andall-Brereton, Krishna Aryal, Silver Bahendeka, Brice Bicaba, Pascal Bovet, Maria Dorobantu, Farshad Farzadfar, Seyyed-Hadi Ghamari, Gladwell Gathecha, David Guwatudde, Mongal Gurung, Corine Houehanou, Dismand Houinato, Nahla Hwalla, Jutta Jorgensen, Gibson Kagaruki, Khem Karki, Joao Martins, Mary Mayige, Roy Wong McClure, Sahar Saeedi Moghaddam, Omar Mwalim, Kibachio Joseph Mwangi, Bolormaa Norov, Sarah Quesnel-Crooks, Abla Sibai, Lela Sturua, Lindiwe Tsabedze, Chea Wesseh, Pascal Geldsetzer, Rifat Atun, Sebastian Vollmer, Till Bärnighausen, Justine Davies, Mohammed K Ali, Jacqueline A Seiglie, Emily W Gower, Jennifer Manne-Goehler
The prevalence of multiple age-related cardiovascular disease (CVD) risk factors is high among individuals living in low- and middle-income countries. We described receipt of healthcare services for and management of hypertension and diabetes among individuals living with these conditions using individual-level data from 55 nationally representative population-based surveys (2009-2019) with measured blood pressure (BP) and diabetes biomarker. We restricted our analysis to non-pregnant individuals aged 40-69 years and defined three mutually exclusive groups (i...
2024: PLOS Glob Public Health
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