keyword
MENU ▼
Read by QxMD icon Read
search

Paolo pelosi

keyword
https://www.readbyqxmd.com/read/29763713/practice-of-mechanical-ventilation-in-cardiac-arrest-patients-and-effects-of-targeted-temperature-management-a-substudy-of-the-targeted-temperature-management-trial
#1
Matthew B A Harmon, David M P van Meenen, Annelou L I P van der Veen, Jan M Binnenkade, Josef Dankiewicz, Florian Ebner, Niklas Nielsen, Paolo Pelosi, Marcus J Schultz, Janneke Horn, Hans Friberg, Nicole P Juffermans
AIMS: Mechanical ventilation practices in patients with cardiac arrest are not well described. Also, the effect of temperature on mechanical ventilation settings is not known. The aims of this study were 1) to describe practice of mechanical ventilation and its relation with outcome 2) to determine effects of different target temperatures strategies (33 °C versus 36 °C) on mechanical ventilation settings. METHODS: This is a substudy of the TTM-trial in which unconscious survivors of a cardiac arrest due to a cardiac cause were randomized to two TTM strategies, 33 °C (TTM33) and 36 °C (TTM36)...
May 12, 2018: Resuscitation
https://www.readbyqxmd.com/read/29743101/individualized-perioperative-hemodynamic-goal-directed-therapy-in-major-abdominal-surgery-ipegasus-trial-study-protocol-for-a-randomized-controlled-trial
#2
Sandra Funcke, Bernd Saugel, Christian Koch, Dagmar Schulte, Thomas Zajonz, Michael Sander, Angelo Gratarola, Lorenzo Ball, Paolo Pelosi, Savino Spadaro, Riccardo Ragazzi, Carlo Alberto Volta, Thomas Mencke, Amelie Zitzmann, Benedikt Neukirch, Gonzalo Azparren, Marta Giné, Vicky Moral, Hans Otto Pinnschmidt, Oscar Díaz-Cambronero, Maria Jose Alberola Estelles, Marisol Echeverri Velez, Maria Vila Montañes, Javier Belda, Marina Soro, Jaume Puig, Daniel Arnulf Reuter, Sebastian Alois Haas
BACKGROUND: Postoperative morbidity and mortality in patients undergoing surgery is high, especially in patients who are at risk of complications and undergoing major surgery. We hypothesize that perioperative, algorithm-driven, hemodynamic therapy based on individualized fluid status and cardiac output optimization is able to reduce mortality and postoperative moderate and severe complications as a major determinant of the patients' postoperative quality of life, as well as health care costs...
May 9, 2018: Trials
https://www.readbyqxmd.com/read/29739430/relax-restricted-versus-liberal-positive-end-expiratory-pressure-in-patients-without-ards-protocol-for-a-randomized-controlled-trial
#3
Anna Geke Algera, Luigi Pisani, Dennis C J Bergmans, Sylvia den Boer, Corianne A J de Borgie, Frank H Bosch, Karina Bruin, Thomas G Cherpanath, Rogier M Determann, Arjen M Dondorp, Dave A Dongelmans, Henrik Endeman, Jasper J Haringman, Janneke Horn, Nicole P Juffermans, David M van Meenen, Nardo J van der Meer, Maruschka P Merkus, Hazra S Moeniralam, Ilse Purmer, Pieter Roel Tuinman, Mathilde Slabbekoorn, Peter E Spronk, Alexander P J Vlaar, Marcelo Gama de Abreu, Paolo Pelosi, Ary Serpa Neto, Marcus J Schultz, Frederique Paulus
BACKGROUND: Evidence for benefit of high positive end-expiratory pressure (PEEP) is largely lacking for invasively ventilated, critically ill patients with uninjured lungs. We hypothesize that ventilation with low PEEP is noninferior to ventilation with high PEEP with regard to the number of ventilator-free days and being alive at day 28 in this population.  METHODS/DESIGN: The "REstricted versus Liberal positive end-expiratory pressure in patients without ARDS" trial (RELAx) is a national, multicenter, randomized controlled, noninferiority trial in adult intensive care unit (ICU) patients with uninjured lungs who are expected not to be extubated within 24 h...
May 9, 2018: Trials
https://www.readbyqxmd.com/read/29729952/tracheostomy-in-intensive-care-patients-and-families-will-never-walk-alone
#4
EDITORIAL
Paolo Pelosi, Lorenzo Ball, Iole Brunetti, Maria Vargas, Nicolò Patroniti
No abstract text is available yet for this article.
June 2018: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/29705765/practice-of-ventilation-in-middle-income-countries-provent-imic-rationale-and-protocol-for-a-prospective-international-multicentre-observational-study-in-intensive-care-units-in-asia
#5
Luigi Pisani, Anna Geke Algera, Ary Serpa Neto, Areef Ahsan, Abigail Beane, Kaweesak Chittawatanarat, Abul Faiz, Rashan Haniffa, Reza Hashemian, Madiha Hashmi, Hisham Ahmed Imad, Kanishka Indraratna, Shivakumar Iyer, Gyan Kayastha, Bhuvana Krishna, Hassan Moosa, Behzad Nadjm, Rajyabardhan Pattnaik, Sriram Sampath, Louise Thwaites, Ni Ni Tun, Nor'azim Mohd Yunos, Salvatore Grasso, Frederique Paulus, Marcelo Gama de Abreu, Paolo Pelosi, Arjen M Dondorp, Marcus J Schultz
INTRODUCTION: Current evidence on epidemiology and outcomes of invasively mechanically ventilated intensive care unit (ICU) patients is predominantly gathered in resource-rich settings. Patient casemix and patterns of critical illnesses, and probably also ventilation practices are likely to be different in resource-limited settings. We aim to investigate the epidemiological characteristics, ventilation practices and clinical outcomes of patients receiving mechanical ventilation in ICUs in Asia...
April 28, 2018: BMJ Open
https://www.readbyqxmd.com/read/29694201/first-results-from-cuore-a-search-for-lepton-number-violation-via-0%C3%AE-%C3%AE-%C3%AE-decay-of-130-te
#6
C Alduino, F Alessandria, K Alfonso, E Andreotti, C Arnaboldi, F T Avignone, O Azzolini, M Balata, I Bandac, T I Banks, G Bari, M Barucci, J W Beeman, F Bellini, G Benato, A Bersani, D Biare, M Biassoni, F Bragazzi, A Branca, C Brofferio, A Bryant, A Buccheri, C Bucci, C Bulfon, A Camacho, A Caminata, L Canonica, X G Cao, S Capelli, M Capodiferro, L Cappelli, L Cardani, M Cariello, P Carniti, M Carrettoni, N Casali, L Cassina, R Cereseto, G Ceruti, A Chiarini, D Chiesa, N Chott, M Clemenza, D Conventi, S Copello, C Cosmelli, O Cremonesi, C Crescentini, R J Creswick, J S Cushman, A D'Addabbo, D D'Aguanno, I Dafinei, V Datskov, C J Davis, F Del Corso, S Dell'Oro, M M Deninno, S Di Domizio, M L Di Vacri, L Di Paolo, A Drobizhev, L Ejzak, R Faccini, D Q Fang, M Faverzani, E Ferri, F Ferroni, E Fiorini, M A Franceschi, S J Freedman, B K Fujikawa, R Gaigher, A Giachero, L Gironi, A Giuliani, L Gladstone, J Goett, P Gorla, C Gotti, C Guandalini, M Guerzoni, T D Gutierrez, E E Haller, K Han, E V Hansen, K M Heeger, R Hennings-Yeomans, K P Hickerson, H Z Huang, M Iannone, L Ioannucci, R Kadel, G Keppel, L Kogler, Yu G Kolomensky, A Leder, C Ligi, K E Lim, X Liu, Y G Ma, C Maiano, M Maino, L Marini, M Martinez, C Martinez Amaya, R H Maruyama, Y Mei, N Moggi, S Morganti, P J Mosteiro, S S Nagorny, T Napolitano, M Nastasi, S Nisi, C Nones, E B Norman, V Novati, A Nucciotti, I Nutini, T O'Donnell, M Olcese, E Olivieri, F Orio, D Orlandi, J L Ouellet, C E Pagliarone, M Pallavicini, V Palmieri, L Pattavina, M Pavan, M Pedretti, R Pedrotta, A Pelosi, G Pessina, V Pettinacci, G Piperno, C Pira, S Pirro, S Pozzi, E Previtali, F Reindl, F Rimondi, L Risegari, C Rosenfeld, C Rossi, C Rusconi, M Sakai, E Sala, C Salvioni, S Sangiorgio, D Santone, D Schaeffer, B Schmidt, J Schmidt, N D Scielzo, V Singh, M Sisti, A R Smith, F Stivanello, L Taffarello, L Tatananni, M Tenconi, F Terranova, M Tessaro, C Tomei, G Ventura, M Vignati, S L Wagaarachchi, J Wallig, B S Wang, H W Wang, B Welliver, J Wilson, K Wilson, L A Winslow, T Wise, L Zanotti, C Zarra, G Q Zhang, B X Zhu, S Zimmermann, S Zucchelli
The CUORE experiment, a ton-scale cryogenic bolometer array, recently began operation at the Laboratori Nazionali del Gran Sasso in Italy. The array represents a significant advancement in this technology, and in this work we apply it for the first time to a high-sensitivity search for a lepton-number-violating process: ^{130}Te neutrinoless double-beta decay. Examining a total TeO_{2} exposure of 86.3 kg yr, characterized by an effective energy resolution of (7.7±0.5)  keV FWHM and a background in the region of interest of (0...
March 30, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29674995/serum-steroid-ratio-profiles-in-prostate-cancer-a-new-diagnostic-tool-toward-a-personalized-medicine-approach
#7
Adriana Albini, Antonino Bruno, Barbara Bassani, Gioacchino D'Ambrosio, Giuseppe Pelosi, Paolo Consonni, Laura Castellani, Matteo Conti, Simone Cristoni, Douglas M Noonan
Background: Serum steroids are crucial molecules altered in prostate cancer (PCa). Mass spectrometry (MS) is currently the elected technology for the analysis of steroids in diverse biological samples. Steroids have complex biological pathways and stoichiometry and it is important to evaluate their quantitative ratio. MS applications to patient hormone profiling could lead to a diagnostic approach. Methods: Here, we employed the Surface Activated Chemical Ionization-Electrospray-NIST (SANIST) developed in our laboratories, to obtain quantitative serum steroid ratio relationship profiles with a machine learning Bayesian model to discriminate patients with PCa...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29670537/impact-of-different-tidal-volume-levels-at-low-mechanical-power-on-ventilator-induced-lung-injury-in-rats
#8
Lillian Moraes, Pedro L Silva, Alessandra Thompson, Cintia L Santos, Raquel S Santos, Marcos V S Fernandes, Marcelo M Morales, Vanessa Martins, Vera L Capelozzi, Marcelo G de Abreu, Paolo Pelosi, Patricia R M Rocco
Tidal volume (VT ) has been considered the main determinant of ventilator-induced lung injury (VILI). Recently, experimental studies have suggested that mechanical power transferred from the ventilator to the lungs is the promoter of VILI. We hypothesized that, as long as mechanical power is kept below a safe threshold, high VT should not be injurious. The present study aimed to investigate the impact of different VT levels and respiratory rates (RR) on lung function, diffuse alveolar damage (DAD), alveolar ultrastructure, and expression of genes related to inflammation [interleukin (IL)-6], alveolar stretch (amphiregulin), epithelial [club cell secretory protein (CC)16] and endothelial [intercellular adhesion molecule (ICAM)-1] cell injury, and extracellular matrix damage [syndecan-1, decorin, and metalloproteinase (MMP)-9] in experimental acute respiratory distress syndrome (ARDS) under low-power mechanical ventilation...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29658904/reply-to-high-versus-low-positive-end-expiratory-pressure-for-abdominal-surgery
#9
Tanja A Treschan, Marcelo Gama de Abreu, Paolo Pelosi, Marcus J Schultz
No abstract text is available yet for this article.
January 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29656020/odorant-binding-protein-based-identification-of-natural-spatial-repellents-for-the-african-malaria-mosquito-anopheles-gambiae
#10
Thomas Kröber, Konstantinos Koussis, Martine Bourquin, Panagiota Tsitoura, Maria Konstantopoulou, Taiwo Sam Awolola, Francesca R Dani, Huili Qiao, Paolo Pelosi, Kostas Iatrou, Patrick M Guerin
There is increasing interest in the development of effective mosquito repellents of natural origin to reduce transmission of diseases such as malaria and yellow fever. To achieve this we have employed an in vitro competition assay involving odorant-binding proteins (OBPs) of the malaria mosquito, Anopheles gambiae, with a predominantly female expression bias to identify plant essential oils (EOs) containing bioactive compounds that target mosquito olfactory function. EOs and their fractions capable of binding to such OBPs displayed repellence against female mosquitoes in a laboratory repellent assay...
April 12, 2018: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29653265/proteomic-analysis-of-chemosensory-organs-in-the-honey-bee-parasite-varroa-destructor-a-comprehensive-examination-of-the-potential-carriers-for-semiochemicals
#11
Immacolata Iovinella, Alison McAfee, Guido Mastrobuoni, Stefan Kempa, Leonard J Foster, Paolo Pelosi, Francesca Romana Dani
We have performed a proteomic analysis on chemosensory organs of Varroa destructor, the honey bee mite, in order to identify putative soluble carriers for pheromones and other olfactory cues emitted by the host. In particular, we have analysed forelegs, mouthparts (palps, chelicera and hypostome) and the second pair of legs (as control tissue) in reproductive and phoretic stages of the Varroa life cycle. We identified 958 Varroa proteins, most of them common to the different organs and stages. Sequence analysis shows that four proteins can be assigned to the odorant-binding protein (OBP)-like class, which bear some similarity to insect OBPs, but so far have only been reported in some Chelicerata...
April 10, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29575957/ventilator-induced-lung-injury-during-controlled-ventilation-in-patients-with-acute-respiratory-distress-syndrome-less-is-probably-better
#12
Fernanda Ferreira Cruz, Lorenzo Ball, Patricia Rieken Macedo Rocco, Paolo Pelosi
Mechanical ventilation is required to support respiratory function in the acute respiratory distress syndrome (ARDS), but it may promote lung damage, a phenomenon known as ventilator-induced lung injury (VILI). Areas covered: Several mechanisms of VILI have been described, such as: inspiratory and/or expiratory stress inducing overdistension (volutrauma); interfaces between collapsed or edema-filled alveoli with surrounding open alveoli, acting as stress raisers; alveoli that repetitively open and close during tidal breathing (atelectrauma); and peripheral airway dynamics...
March 26, 2018: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/29566734/acute-exacerbation-of-idiopathic-pulmonary-fibrosis-lessons-learned-from-acute-respiratory-distress-syndrome
#13
REVIEW
Alessandro Marchioni, Roberto Tonelli, Lorenzo Ball, Riccardo Fantini, Ivana Castaniere, Stefania Cerri, Fabrizio Luppi, Mario Malerba, Paolo Pelosi, Enrico Clini
Idiopathic pulmonary fibrosis (IPF) is a fibrotic lung disease characterized by progressive loss of lung function and poor prognosis. The so-called acute exacerbation of IPF (AE-IPF) may lead to severe hypoxemia requiring mechanical ventilation in the intensive care unit (ICU). AE-IPF shares several pathophysiological features with acute respiratory distress syndrome (ARDS), a very severe condition commonly treated in this setting.A review of the literature has been conducted to underline similarities and differences in the management of patients with AE-IPF and ARDS...
March 23, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29564726/potentially-modifiable-respiratory-variables-contributing-to-outcome-in-icu-patients-without-ards-a-secondary-analysis-of-provent
#14
Fabienne D Simonis, Carmen S V Barbas, Antonio Artigas-Raventós, Jaume Canet, Rogier M Determann, James Anstey, Goran Hedenstierna, Sabrine N T Hemmes, Greet Hermans, Michael Hiesmayr, Markus W Hollmann, Samir Jaber, Ignacio Martin-Loeches, Gary H Mills, Rupert M Pearse, Christian Putensen, Werner Schmid, Paolo Severgnini, Roger Smith, Tanja A Treschan, Edda M Tschernko, Marcos F Vidal Melo, Hermann Wrigge, Marcelo Gama de Abreu, Paolo Pelosi, Marcus J Schultz, Ary Serpa Neto
BACKGROUND: The majority of critically ill patients do not suffer from acute respiratory distress syndrome (ARDS). To improve the treatment of these patients, we aimed to identify potentially modifiable factors associated with outcome of these patients. METHODS: The PRoVENT was an international, multicenter, prospective cohort study of consecutive patients under invasive mechanical ventilatory support. A predefined secondary analysis was to examine factors associated with mortality...
March 21, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29558993/close-down-the-lungs-and-keep-them-resting-to-minimize-ventilator-induced-lung-injury
#15
REVIEW
Paolo Pelosi, Patricia Rieken Macedo Rocco, Marcelo Gama de Abreu
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2018. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2018 . Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series/8901 .
March 20, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29489470/biologic-impact-of-mechanical-power-at-high-and-low-tidal-volumes-in-experimental-mild-acute-respiratory-distress-syndrome
#16
Raquel S Santos, Ligia de A Maia, Milena V Oliveira, Cíntia L Santos, Lillian Moraes, Eliete F Pinto, Cynthia Dos S Samary, Joana A Machado, Anna Carolinna Carvalho, Marcos Vinícius de S Fernandes, Vanessa Martins, Vera L Capelozzi, Marcelo M Morales, Thea Koch, Marcelo Gama de Abreu, Paolo Pelosi, Pedro L Silva, Patricia R M Rocco
BACKGROUND: The authors hypothesized that low tidal volume (VT) would minimize ventilator-induced lung injury regardless of the degree of mechanical power. The authors investigated the impact of power, obtained by different combinations of VT and respiratory rate (RR), on ventilator-induced lung injury in experimental mild acute respiratory distress syndrome (ARDS). METHODS: Forty Wistar rats received Escherichia coli lipopolysaccharide intratracheally. After 24 h, 32 rats were randomly assigned to be mechanically ventilated (2 h) with a combination of different VT (6 ml/kg and 11 ml/kg) and RR that resulted in low and high power...
February 28, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29486489/effect-of-on-demand-vs-routine-nebulization-of-acetylcysteine-with-salbutamol-on-ventilator-free-days-in-intensive-care-unit-patients-receiving-invasive-ventilation-a-randomized-clinical-trial
#17
RANDOMIZED CONTROLLED TRIAL
David M P van Meenen, Sophia M van der Hoeven, Jan M Binnekade, Corianne A J M de Borgie, Maruschka P Merkus, Frank H Bosch, Henrik Endeman, Jasper J Haringman, Nardo J M van der Meer, Hazra S Moeniralam, Mathilde Slabbekoorn, Marcella C A Muller, Willemke Stilma, Bart van Silfhout, Ary Serpa Neto, Hans F M Ter Haar, Jan Van Vliet, Jan Willem Wijnhoven, Janneke Horn, Nicole P Juffermans, Paolo Pelosi, Marcelo Gama de Abreu, Marcus J Schultz, Frederique Paulus
Importance: It remains uncertain whether nebulization of mucolytics with bronchodilators should be applied for clinical indication or preventively in intensive care unit (ICU) patients receiving invasive ventilation. Objective: To determine if a strategy that uses nebulization for clinical indication (on-demand) is noninferior to one that uses preventive (routine) nebulization. Design, Setting, and Participants: Randomized clinical trial enrolling adult patients expected to need invasive ventilation for more than 24 hours at 7 ICUs in the Netherlands...
March 13, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29472868/niemann-pick-c2-proteins-a-new-function-for-an-old-family
#18
Jiao Zhu, Mengbuo Guo, Liping Ban, Li-Mei Song, Yang Liu, Paolo Pelosi, Guirong Wang
Niemann-Pick proteins type C2 (NPC2) are carriers of cholesterol in vertebrates, with a single member in each species. The high sequence conservation between mammals and across vertebrates is related to their common function. In contrast, NPC2 proteins in arthropods have undergone extensive duplication and differentiation, probably under environmental pressure, and are likely to have different functions. Recent studies have suggested that in arthropods these proteins might act as carriers for semiochemicals and other hydrophobic compounds...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29464297/correction-to-external-confirmation-and-exploration-of-the-kigali-modification-for-diagnosing-moderate-or-severe-ards
#19
Veronica Vercesi, Luigi Pisani, Patricia S I van Tongeren, Wim K Lagrand, Stije J Leopold, Mischa M A Huson, Patricia C Henwood, Andrew Walden, Marry Smit, Elisabeth D Riviello, Paolo Pelosi, Arjen M Dondorp, Marcus J Schultz
In Table 1 of this article, the numerical data were correct but the graphic part was imprecise.
March 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/29430442/effects-of-peep-on-lung-injury-pulmonary-function-systemic-circulation-and-mortality-in-animals-with-uninjured-lungs-a-systematic-review
#20
REVIEW
Anna Geke Algera, Luigi Pisani, Renato Carneiro de Freitas Chaves, Thiago Chaves Amorim, Thomas Cherpanath, Rogier Determann, Dave A Dongelmans, Frederique Paulus, Pieter Roel Tuinman, Paolo Pelosi, Marcelo Gama de Abreu, Marcus J Schultz, Ary Serpa Neto
It is well-known that positive end-expiratory pressure (PEEP) can prevent ventilator-induced lung injury (VILI) and improve pulmonary physiology in animals with injured lungs. It's uncertain whether PEEP has similar effects in animals with uninjured lungs. A systematic review of randomized controlled trials (RCTs) comparing different PEEP levels in animals with uninjured lungs was performed. Trials in animals with injured lungs were excluded, as were trials that compared ventilation strategies that also differed with respect to other ventilation settings, e...
January 2018: Annals of Translational Medicine
keyword
keyword
74420
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"