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https://www.readbyqxmd.com/read/29788844/the-first-five-years-of-neonatal-and-pediatric-transports-on-extracorporeal-membrane-oxygenation-in-the-center-and-south-of-italy-the-pediatric-branch-of-the-italian-rete-respira-network
#1
Matteo Di Nardo, Margherita Lonero, Elisabetta Pasotti, Federica Cancani, Daniela Perrotta, Corrado Cecchetti, Francesca Stoppa, Nicola Pirozzi, Ondina La Salvia, Antonella Nicolini, Antonio Amodeo, Nicolo' Patroniti, Antonio Pesenti
INTRODUCTION: Neonatal and pediatric ECMO is a high-risk procedure that should be performed only in expert centers. Children who are eligible for ECMO and are managed in hospitals without ECMO capabilities should be referred to the closest ECMO center before the severity of illness precludes safe conventional transport. When the clinical situation precludes safe conventional transport, ECMO should be provided on site with the patient transported on ECMO. METHODS: We retrospectively reviewed our institutional database of all ECMO transports for neonatal and pediatric respiratory failure from February 2013 to February 2018...
May 2018: Perfusion
https://www.readbyqxmd.com/read/29787743/persistence-of-central-venous-oxygen-desaturation-during-early-sepsis-is-associated-with-higher-mortality-a-retrospective-analysis-of-the-albios-trial
#2
Alessandro Protti, Serge Masson, Roberto Latini, Roberto Fumagalli, Marilena Romero, Carla Pessina, Giovanni Pasetti, Gianni Tognoni, Antonio Pesenti, Luciano Gattinoni, Pietro Caironi
BACKGROUND: Relevance of low (<70%) central venous oxygen saturation (ScvO2 ) during early sepsis has been recently questioned by three negative trials (ProCESS, ARISE and ProMISe) on early goal-directed therapy (EGDT). However, subjects included in those trials had ScvO2 at enrolment as high as 71±13%, 73±11% and 70±12%. Herein we assessed the association between ScvO2 <70% at six hours and 90-day mortality in subjects enrolled in the ALBIOS trial, focusing on those with initial ScvO2 <70%...
May 19, 2018: Chest
https://www.readbyqxmd.com/read/29783879/effects-of-sodium-citrate-citric-acid-and-lactic-acid-on-human-blood-coagulation
#3
Vittorio Scaravilli, Luca Di Girolamo, Eleonora Scotti, Mattia Busana, Osvaldo Biancolilli, Patrizia Leonardi, Andrea Carlin, Caterina Lonati, Mauro Panigada, Antonio Pesenti, Alberto Zanella
INTRODUCTION: Citric acid infusion in extracorporeal blood may allow concurrent regional anticoagulation and enhancement of extracorporeal CO2 removal. Effects of citric acid on human blood thromboelastography and aggregometry have never been tested before. METHODS: In this in vitro study, citric acid, sodium citrate and lactic acid were added to venous blood from seven healthy donors, obtaining concentrations of 9 mEq/L, 12 mEq/L and 15 mEq/L. We measured gas analyses, ionized calcium (iCa++ ) concentration, activated clotting time (ACT), thromboelastography and multiplate aggregometry...
May 1, 2018: Perfusion
https://www.readbyqxmd.com/read/29779559/corrigendum-to-variants-of-%C3%AE-casofensin-a-bioactive-milk-peptide-differently-modulate-the-intestinal-barrier-in-vivo-and-ex-vivo-studies-in-rats-j-dairy-sci-100-3360-3372
#4
J Bruno, A Nicolas, S Pesenti, J Schwarz, J-L Simon, J Léonil, P Plaisancié
No abstract text is available yet for this article.
June 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29769562/common-drivers-of-seasonal-movements-on-the-migration-residency-behavior-continuum-in-a-large-herbivore
#5
Jodie Martin, Vincent Tolon, Nicolas Morellet, Hugues Santin-Janin, Alain Licoppe, Claude Fischer, Jérôme Bombois, Patrick Patthey, Elias Pesenti, Delphine Chenesseau, Sonia Saïd
This study aimed to (1) identify the scale of environmental drivers of seasonal movements on the migration - residency behavior continuum in a large herbivore species and to (2) test the hypothesis that the same environmental drivers and spatio-temporal scaling should influence spatial processes in both migrants (long distance migration) and residents (short distance range shifts). We performed a comparative analysis of the influence of plant phenology and snow cover duration on seasonal movements of five partially migrating red deer populations with contrasting environmental conditions, at the seasonal range scale and at the study area scale...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29746315/antithrombin-during-extracorporeal-membrane-oxygenation-in-adults-national-survey-and-retrospective-analysis
#6
Giacomo E Iapichino, Alessandro Protti, Davide T Andreis, Mauro Panigada, Andrea Artoni, Cristina Novembrino, Antonio Pesenti, Luciano Gattinoni
The impact of antithrombin replacement during extracorporeal membrane oxygenation (ECMO) in adults remains unclear. This work comprises a survey, showing that antithrombin is routinely supplemented in many Italian ECMO-Centers, and a retrospective analysis on 66 adults treated with veno-venous ECMO and unfractionated heparin at our Institution. Twenty-four to 72 h after the beginning of ECMO, antithrombin activity was ≤70% in 47/66 subjects and activated partial thromboplastin time (aPTT) ratio was <1...
May 8, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29743098/impact-of-flow-and-temperature-on-patient-comfort-during-respiratory-support-by-high-flow-nasal-cannula
#7
Tommaso Mauri, Alessandro Galazzi, Filippo Binda, Laura Masciopinto, Nadia Corcione, Eleonora Carlesso, Marta Lazzeri, Elena Spinelli, Daniela Tubiolo, Carlo Alberto Volta, Ileana Adamini, Antonio Pesenti, Giacomo Grasselli
BACKGROUND: The high-flow nasal cannula (HFNC) delivers up to 60 l/min of humidified air/oxygen blend at a temperature close to that of the human body. In this study, we tested whether higher temperature and flow decrease patient comfort. In more severe patients, instead, we hypothesized that higher flow might be associated with improved comfort. METHODS: A prospective, randomized, cross-over study was performed on 40 acute hypoxemic respiratory failure (AHRF) patients (PaO2 /FiO2  ≤ 300 + pulmonary infiltrates + exclusion of cardiogenic edema) supported by HFNC...
May 9, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29730130/effects-of-early-intervention-on-feeding-behavior-in-preterm-infants-a-randomized-controlled-trial
#8
Camilla Fontana, Camilla Menis, Nicola Pesenti, Sofia Passera, Nadia Liotto, Fabio Mosca, Paola Roggero, Monica Fumagalli
BACKGROUND: Although highly beneficial, human milk feeding is challenging in preterm infants due to adverse NICU factors for the infant and mother. AIM: To investigate the effects of an early intervention in promoting infant's human milk feeding and acquisition of full oral feeding. METHODS: This study is part of a RCT. We included preterm infants born between 25+0 and 29+6 weeks of gestational age (GA) without severe morbidities, and their parents...
May 3, 2018: Early Human Development
https://www.readbyqxmd.com/read/29715228/cervical-facet-orientation-varies-with-age-in-children-an-mri-study
#9
Sebastien Pesenti, Renaud Lafage, Virginie Lafage, Michel Panuel, Benjamin Blondel, Jean-Luc Jouve
BACKGROUND: Within the spine, mobility and stability are principles that drive anatomic morphology. Based on radiographic measurements, the orientation of cervical facet joints has been proven to change throughout child growth. However, because of the mainly cartilaginous composition of the vertebrae in the young child, the lack of osseous landmarks makes radiograph-based measurements unreliable. The aims of our study were to evaluate the change in the sagittal orientation of the cervical facet joints with age based on magnetic resonance imaging (MRI) of asymptomatic children and to compare it to the changes in vertebral body dimensions...
May 2, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29687523/safety-of-anesthesia-for-children-with-mucopolysaccharidoses-a-retrospective-analysis-of-54-patients
#10
Vittorio Scaravilli, Alberto Zanella, Valentina Ciceri, Mariagrazia Bosatra, Claudia Flandoli, Alessia La Bruna, Simone Sosio, Rossella Parini, Serena Gasperini, Antonio Pesenti, Alessandra Moretto
BACKGROUND: Complications are common during anesthesia for patients with mucopolysaccharidoses. San Gerardo Hospital (Italy) is a reference center for mucopolysaccharidoses with a dedicated pediatric anesthesia service. AIMS: This study aims to evaluate the safety of anesthesia for mucopolysaccharidoses patients, describe their anesthetic management at our institution, and assess risk factors for complications. METHODS: The anesthetic charts of mucopolysaccharidoses patients admitted from January 1999 to December 2014 were retrospectively analyzed...
April 23, 2018: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29680449/modeling-tumor-growth-inhibition-and-toxicity-outcome-after-administration-of-anticancer-agents-in-xenograft-mice-a-dynamic-energy-budget-deb-approach
#11
N Terranova, E M Tosca, E Borella, E Pesenti, M Rocchetti, P Magni
Host features, such as cell proliferation rates, caloric intake, metabolism and energetic conditions, significantly influence tumor growth; at the same time, tumor growth may have a dramatic impact on the host conditions. For example, in clinics, at certain stages of the tumor growth, cachexia (body weight reduction) may become so relevant to be considered as responsible for around 20% of cancer deaths. Unfortunately, anticancer therapies may also contribute to the development of cachexia due to reduced food intake (anorexia), commonly observed during the treatment periods...
April 19, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29668546/induction-dosage-of-propofol-for-repeated-sedations-in-children-with-hematological-disorders
#12
Alessandra Moretto, Alberto Zanella, Valentina Ciceri, Matteo Rota, Vittorio Scaravilli, Virginia Beltrama, Mariagrazia Bosatra, Antonio Pesenti
Pediatric patients with hematologic malignancies require several procedural sedations by means of propofol infusion. We retrospectively analyzed the medical records of leukemic pediatric patients who had undergone procedural sedations at an Italian tertiary referral center (San Gerardo Hospital, Monza) from January 2011 to November 2013. We retrieved the following: demographics; diagnosis; chemotherapy phase; use of corticosteroids; induction dosage of propofol, fentanyl and/or ketamine; and the type of procedure...
April 17, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29663667/a-novel-splice-site-variant-in-itpr1-gene-underlying-recessive-gillespie-syndrome
#13
Leda Paganini, Chiara Pesenti, Donatella Milani, Laura Fontana, Silvia Motta, Silvia Maria Sirchia, Giulietta Scuvera, Paola Marchisio, Susanna Esposito, Claudia Maria Cinnante, Silvia Maria Tabano, Monica Rosa Miozzo
Gillespie syndrome (GLSP) is a rare congenital disorder characterized by partial aniridia, hypotonia, progressive cerebellar hypoplasia, nonprogressive ataxia, and intellectual disability. All causative variants to date affect the central or the 3'-terminal domains of ITPR1 gene and exhibit autosomal recessive or dominant inheritance pattern. We investigated by exome sequencing the molecular cause of GLSP in a family composed by consanguineous healthy parents, two affected siblings and one healthy son. We found the novel splice site variant c...
April 16, 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29663042/ted-kolobow
#14
EDITORIAL
Luciano Gattinoni, Antonio Pesenti, Lorenzo Berra, Robert Bartlett
No abstract text is available yet for this article.
April 16, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/29627848/fixation-augmentation-using-calcium-phosphate-bone-substitute-improves-outcomes-of-complex-tibial-plateau-fractures-a-matched-cohort-study
#15
Matthieu Ollivier, Yassine Bulaïd, Christophe Jacquet, Sebastien Pesenti, Jean-Noel Argenson, Sebastien Parratte
INTRODUCTION: Injectable cements have been developed to improve fixation's stability and thus obtain early return to adequate joint function. We aimed to compare post-operative radiographic and clinical outcomes of patients suffering from a complex tibial plateau fracture (TPF) fixed with calcium-phosphate bone substitutes (CPBS) augmentation to a matched group of patients with identical fracture pattern, treated with the same fixation's type, but augmented with bone grafting. METHODS: After local ethic committee approval, we retrospectively identified in a prospectively collected database, patients with complex comminuted metaphyseal and epiphysial bicondylar TPF (Schatzker type VI) admitted in our emergency department between January 2011 and December 2013...
April 7, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29600794/fluid-collection-after-partial-pancreatectomy-eus-drainage-and-long-term-follow-up
#16
Fabrice Caillol, Sebastien Godat, Olivier Turrini, Christophe Zemmour, Erwan Bories, Christian Pesenti, Jean Phillippe Ratone, Jacques Ewald, Jean Robert Delpero, Marc Giovannini
Background and Objectives: Postoperative fluid collection due to pancreatic leak is the most frequent complication after pancreatic surgery. Endoscopic ultrasound (EUS)-guided drainage of post-pancreatic surgery fluid collection is the gold standard procedure; however, data on outcomes of this procedure are limited. The primary endpoint of our study was relapse over longterm followup, and the secondary endpoint was the efficiency and safety of EUS-guided drainage of post-pancreatic surgery fluid collection...
March 29, 2018: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/29594440/clinical-safety-of-3-t-brain-magnetic-resonance-imaging-in-newborns
#17
Monica Fumagalli, Claudia Maria Cinnante, Sonia Francesca Calloni, Gabriele Sorrentino, Ilaria Gorla, Laura Plevani, Nicola Pesenti, Ida Sirgiovanni, Fabio Mosca, Fabio Triulzi
BACKGROUND: The effects and potential hazards of brain magnetic resonance imaging (MRI) at 3 T in newborns are debated. OBJECTIVE: Assess the impact of 3-T MRI in newborns on body temperature and physiological parameters. MATERIAL AND METHODS: Forty-nine newborns, born preterm and at term, underwent 3-T brain MRI at term-corrected age. Rectal and skin temperature, oxygen saturation and heart rate were recorded before, during and after the scan...
March 29, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29565577/generation-of-a-synthetic-human-chromosome-with-two-centromeric-domains-for-advanced-epigenetic-engineering-studies
#18
Elisa Pesenti, Natalay Kouprina, Mikhail Liskovykh, Joan Aurich-Costa, Vladimir Larionov, Hiroshi Masumoto, William C Earnshaw, Oscar Molina
It is generally accepted that chromatin containing the histone H3 variant CENP-A is an epigenetic mark maintaining centromere identity. However, the pathways leading to the formation and maintenance of centromere chromatin remain poorly characterized due to difficulties of analysis of centromeric repeats in native chromosomes. To address this problem, in our previous studies we generated a human artificial chromosome (HAC) whose centromere contains a synthetic alpha-satellite (alphoid) DNA array containing the tetracycline operator, the alphoidtetO-HAC...
March 22, 2018: ACS Synthetic Biology
https://www.readbyqxmd.com/read/29529627/no-benefit-of-computer-assisted-tka-10-year-results-of-a-prospective-randomized-study
#19
Matthieu Ollivier, Sébastien Parratte, Ludovic Lino, Xavier Flecher, Sébastien Pesenti, Jean-Noël Argenson
BACKGROUND: Previously published studies reported benefits of computer-assisted surgery (CAS) in terms of radiographic implant position in TKA, but whether these improvements result in clinically important survival differences or functional differences that a patient might perceive at a minimum 10-year followup remains largely unknown. QUESTIONS/PURPOSES: We performed a prospective randomized trial and asked whether CAS (1) improved survival free from aseptic loosening; and (2) demonstrated any clear difference in patient-reported outcomes at latest followup using validated outcome measures at minimum 10-year followup...
January 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29481867/circumferential-minimally-invasive-approach-for-low-grade-isthmic-spondylolisthesis-a-clinical-and-radiological-study-of-43-patients
#20
K Farah, T Graillon, P Rakotozanany, S Pesenti, B Blondel, S Fuentes
INTRODUCTION: Circumferential fusion for lumbar low-grade isthmic spondylolisthesis (LGIS) provides the best spinal stability and highest fusion rates. The aim of this study is to investigate results of minimal invasive management of LGIS and correlations between Intervertebral Foramen Surface (IFS) and other parameters. METHODS: We retrospectively reviewed cases of 43 patients who underwent a minimally invasive circumferential fusion (Anterior lumbar interbody fusion followed by percutaneous posterior pedicle screw fixation) for LGIS between January 2010 and December 2014 in our institution...
February 23, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
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