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https://www.readbyqxmd.com/read/29211496/reply-to-precision-medicine-for-extracorporeal-co2-removal-for-ards-co2-physiological-considerations
#1
Ewan C Goligher, Marcelo B P Amato, Arthur S Slutsky
No abstract text is available yet for this article.
December 6, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29208159/reduction-in-undiagnosed-hiv-infection-in-the-european-union-european-economic-area-2012-to-2016
#2
Ard van Sighem, Anastasia Pharris, Chantal Quinten, Teymur Noori, Andrew J Amato-Gauci, The Ecdc Hiv/Aids Surveillance And Dublin Declaration Monitoring Networks
It is well-documented that early HIV diagnosis and linkage to care reduces morbidity and mortality as well as HIV transmission. We estimated the median time from HIV infection to diagnosis in the European Union/European Economic Area (EU/EEA) at 2.9 years in 2016, with regional variation. Despite evidence of a decline in the number of people living with undiagnosed HIV in the EU/EEA, many remain undiagnosed, including 33% with more advanced HIV infection (CD4 < 350 cells/mm3).
November 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29208158/hiv-testing-in-europe-evaluating-the-impact-added-value-relevance-and-usability-of-the-european-centre-for-disease-prevention-and-control-ecdc-s-2010-hiv-testing-guidance
#3
Ann K Sullivan, Ida Sperle, Dorthe Raben, Andrew J Amato-Gauci, Jens Dilling Lundgren, Yazdan Yazdanpanah, Stine Finne Jakobsen, Lara Tavoschi
BACKGROUND: An evaluation of the 2010 ECDC guidance on HIV testing, conducted in October 2015-January 2016, assessed its impact, added value, relevance and usability and the need for updated guidance. METHODS: Data sources were two surveys: one for the primary target audience (health policymakers and decision makers, national programme managers and ECDC official contact points in the European Union/European Economic Area (EU/EEA) countries and one for a broader target audience (clinicians, civil society organisations and international public health agencies); two moderated focus group discussions  (17 participants each); webpage access data; a literature citation review; and an expert consultation (18 participants) to discuss the evaluation findings...
November 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29207559/tooth-wear-is-frequent-in-adult-patients-with-celiac-disease
#4
Massimo Amato, Fabiana Zingone, Mario Caggiano, Paola Iovino, Cristina Bucci, Carolina Ciacci
(1) Background: Celiac disease (CD) patients can be affected by mouth and tooth disorders, which are influenced by their gluten-free diet. The aim of our research was to evaluate the pathological conditions of the stomatognathic system observed in celiac patients on a gluten-free diet. (2) Methods: we consecutively recruited celiac patients on a gluten-free diet at our celiac center, as well as healthy volunteers. Two dentists examined all patients/controls and checked them for any mouth disorder. (3) Results: Forty-nine patients affected by celiac disease (age at test 31...
December 4, 2017: Nutrients
https://www.readbyqxmd.com/read/29205995/volume-and-health-outcomes-evidence-from-systematic-reviews-and-from-evaluation-of-italian-hospital-data
#5
Laura Amato, Danilo Fusco, Anna Acampora, Katia Bontempi, Alessandro Cesare Rosa, Paola Colais, Fabio Cruciani, Mariangela D'Ovidio, Francesca Mataloni, Silvia Minozzi, Zuzana Mitrova, Luigi Pinnarelli, Rosella Saulle, Salvatore Soldati, Chiara Sorge, Simona Vecchi, Martina Ventura, Marina Davoli
BACKGROUND Improving quality and effectiveness of healthcare is one of the priorities of health policies. Hospital or physician volume represents a measurable variable with an impact on effectiveness of healthcare. An Italian law calls for the definition of «qualitative, structural, technological, and quantitative standards of hospital care». There is a need for an evaluation of the available scientific evidence in order to identify qualitative, structural, technological, and quantitative standards of hospital care, including the volume of care above or below which the public and private hospitals may be accredited (or not) to provide specific healthcare interventions...
September 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/29205877/molecular-epidemiology-of-mycobacterium-tuberculosis-complex-strains-isolated-from-livestock-and-wild-animals-in-italy-suggests-the-need-for-a-different-eradication-strategy-for-bovine-tuberculosis
#6
B Amato, V Di Marco Lo Presti, E Gerace, M T Capucchio, M Vitale, P Zanghì, M L Pacciarini, C Marianelli, M B Boniotti
Bovine tuberculosis (bTB) is an important zoonosis, which has been re-emerging in different ecological scenarios. In Sicily, Italy, from 2004 to 2014, an anatomopathological survey for tuberculosis-like lesions both in farmed and wild animals was performed. The isolates were genotyped using spoligotyping and Mycobacterial Interspersed Repetitive Units-Variable Number of Tandem Repeats (MIRU-VNTR) techniques. High prevalence of lesions was observed for cattle (4%), pigs (4.9%) and wild boars (6.8%), and a total of 625 Mycobacterium bovis isolates were identified...
December 3, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29205327/social-behaviour-and-gut-microbiota-in-red-bellied-lemurs-eulemur-rubriventer-in-search-of-the-role-of-immunity-in-the-evolution-of-sociality
#7
Aura Raulo, Lasse Ruokolainen, Avery Lane, Katherine Amato, Rob Knight, Steven Leigh, Rebecca Stumpf, Bryan White, Karen E Nelson, Andrea L Baden, Stacey R Tecot
Vertebrate gut microbiota form a key component of immunity and a dynamic link between an individual and the ecosystem. Microbiota might play a role in social systems as well, because microbes are transmitted during social contact and can affect host behaviour. Combining methods from behavioural and molecular research, we describe the relationship between social dynamics and gut microbiota of a group-living cooperative species of primate, the red-bellied lemur (Eulemur rubriventer). Specifically, we ask whether patterns of social contact (group membership, group size, position in social network, individual sociality) are associated with patterns of gut microbial composition (diversity and similarity) between individuals and across time...
December 5, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/29200026/severe-aortic-valve-regurgitation-in-relapsing-polychondritis
#8
Francesca Wanda Rossi, Valentina Mercurio, Felice Rivellese, Antonio Lobasso, Letizia Barbieri, Carlo Gabriele Tocchetti, Amato de Paulis, Gianni Marone
No abstract text is available yet for this article.
December 1, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29196444/temporal-analysis-of-hippocampal-ca3-gene-co-expression-networks-in-a-rat-model-of-febrile-seizures
#9
Hatylas Azevedo, Nathália Amato Khaled, Paula Santos, Fernanda Bernardi Bertonha, Carlos Alberto Moreira-Filho
Complex febrile seizures during infancy constitute an important risk factor for epilepsy development. However, little is known about the alterations induced by febrile seizures that may turn the brain susceptible to epileptic activity. In this context, the use of animal models of hyperthermic seizures (HS) could allow the temporal analysis of brain molecular changes that arise after febrile seizures. Here, we investigated temporal changes in hippocampal gene co-expression networks during the development of rats submitted to HS...
November 30, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29196041/nose-to-brain-delivery-of-insulin-enhanced-by-a-nanogel-carrier
#10
Pasquale Picone, Maria Antonietta Sabatino, Lorena Anna Ditta, Antonella Amato, Pier L San Biagio, Flavia Mulè, Daniela Giacomazza, Clelia Dispenza, Marta Di Carlo
Recent evidences suggest that insulin delivery to the brain can be an important pharmacological therapy for some neurodegenerative pathologies, including Alzheimer disease (AD). Due to the presence of the Blood Brain Barrier, a suitable carrier and an appropriate route of administration are required to increase the efficacy and safety of the treatment. Here, poly(N-vinyl pyrrolidone)-based nanogels (NG), synthetized by e-beam irradiation, alone and with covalently attached insulin (NG-In) were characterized for biocompatibility and brain delivery features in a mouse model...
November 28, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29191847/wasp-family-proteins-and-formins-compete-in-pseudopod-and-bleb-based-migration
#11
Andrew J Davidson, Clelia Amato, Peter A Thomason, Robert H Insall
Actin pseudopods induced by SCAR/WAVE drive normal migration and chemotaxis in eukaryotic cells. Cells can also migrate using blebs, in which the edge is driven forward by hydrostatic pressure instead of actin. In Dictyostelium discoideum, loss of SCAR is compensated by WASP moving to the leading edge to generate morphologically normal pseudopods. Here we use an inducible double knockout to show that cells lacking both SCAR and WASP are unable to grow, make pseudopods or, unexpectedly, migrate using blebs. Remarkably, amounts and dynamics of actin polymerization are normal...
November 30, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/29190476/the-janus-face-of-the-thrombin-binding-aptamer-investigating-the-anticoagulant-and-antiproliferative-properties-through-straightforward-chemical-modifications
#12
Veronica Esposito, Annapina Russo, Teresa Amato, Valentina Vellecco, Mariarosaria Bucci, Luciano Mayol, Giulia Russo, Antonella Virgilio, Aldo Galeone
BACKGROUND: The thrombin binding aptamer (TBA) is endowed with both anticoagulant and antiproliferative activities. Its chemico-physical and/or biological properties can be tuned by the site-specific replacement of selected residues. METHODS: Four oligodeoxynucleotides (ODNs) based on the TBA sequence (5'-GGTTGGTGTGGTTGG-3') and containing 2'-deoxyuridine (U) or 5-bromo-2'-deoxyuridine (B) residues at positions 4 or 13 have been investigated by NMR and CD techniques...
November 15, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29189372/multifunctional-assessment-of-non-small-cell-lung-cancer-perfusion-metabolic-correlation
#13
Lucio Calandriello, Anna Rita Larici, Lucia Leccisotti, Annemilia Del Ciello, Giuliano Sica, Amato Infante, Maria Teresa Congedo, Andrea Poscia, Alessandro Giordano, Lorenzo Bonomo
PURPOSE: The aim of this study was to investigate the relationship between whole-tumor CT perfusion and FDG PET/CT parameters in non-small cell lung cancer (NSCLC). METHODS: Twenty-five patients with NSCLC were prospectively included. CT perfusion parameters calculated were blood flow (BF), blood volume (BV), mean transit time, and peak enhancement intensity. SUVmax, SUVpeak, SUVmean, metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were evaluated for PET/CT...
November 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29184534/pronounced-structural-and-functional-damage-in-early-adult-pediatric-onset-multiple-sclerosis-with-no-or-minimal-clinical-disability
#14
Antonio Giorgio, Jian Zhang, Maria Laura Stromillo, Francesca Rossi, Marco Battaglini, Lucia Nichelli, Marzia Mortilla, Emilio Portaccio, Bahia Hakiki, Maria Pia Amato, Nicola De Stefano
Pediatric-onset multiple sclerosis (POMS) may represent a model of vulnerability to damage occurring during a period of active maturation of the human brain. Whereas adaptive mechanisms seem to take place in the POMS brain in the short-medium term, natural history studies have shown that these patients reach irreversible disability, despite slower progression, at a significantly younger age than adult-onset MS (AOMS) patients. We tested for the first time whether significant brain alterations already occurred in POMS patients in their early adulthood and with no or minimal disability (n = 15) in comparison with age- and disability-matched AOMS patients (n = 14) and to normal controls (NC, n = 20)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29181282/modus-operandi-and-affect-in-sweden-the-swedish-version-of-the-regulatory-mode-questionnaire
#15
Clara Amato, Ali Al Nima, Marko Mihailovic, Danilo Garcia
Background: The Regulatory Mode Questionnaire (RMQ) is the most used and internationally well-known instrument for the measurement of individual differences in the two self-regulatory modes: locomotion (i.e., the aspect of self-regulation that is concerned with movement from state to state) and assessment (i.e., the comparative aspect of self-regulation). The aim of the present study was to verify the independence of the two regulatory modes, as postulated by the Regulatory Mode Theory (Kruglanski et al...
2017: PeerJ
https://www.readbyqxmd.com/read/29177080/eular-acr-classification-criteria-for-adult-and-juvenile-idiopathic-inflammatory-myopathies-and-their-major-subgroups-a-methodology-report
#16
Matteo Bottai, Anna Tjärnlund, Giola Santoni, Victoria P Werth, Clarissa Pilkington, Marianne de Visser, Lars Alfredsson, Anthony A Amato, Richard J Barohn, Matthew H Liang, Jasvinder A Singh, Rohit Aggarwal, Snjolaug Arnardottir, Hector Chinoy, Robert G Cooper, Katalin Danko, Mazen M Dimachkie, Brian M Feldman, Ignacio García-De La Torre, Patrick Gordon, Taichi Hayashi, James D Katz, Hitoshi Kohsaka, Peter A Lachenbruch, Bianca A Lang, Yuhui Li, Chester V Oddis, Marzena Olesinka, Ann M Reed, Lidia Rutkowska-Sak, Helga Sanner, Albert Selva-O'Callaghan, Yeong Wook Song, Jiri Vencovsky, Steven R Ytterberg, Frederick W Miller, Lisa G Rider, Ingrid E Lundberg
Objective: To describe the methodology used to develop new classification criteria for adult and juvenile idiopathic inflammatory myopathies (IIMs) and their major subgroups. Methods: An international, multidisciplinary group of myositis experts produced a set of 93 potentially relevant variables to be tested for inclusion in the criteria. Rheumatology, dermatology, neurology and paediatric clinics worldwide collected data on 976 IIM cases (74% adults, 26% children) and 624 non-IIM comparator cases with mimicking conditions (82% adults, 18% children)...
2017: RMD Open
https://www.readbyqxmd.com/read/29165569/preferential-usage-of-specific-immunoglobulin-heavy-chain-variable-region-genes-with-unmutated-profile-and-advanced-stage-at-presentation-are-common-features-in-patients-with-chronic-lymphocytic-leukemia-from-senegal
#17
Teresa Amato, Abibatou Sall, Tandakha NDiaye Dièye, Alessandro Gozzetti, Michele Iacono, Maria Raffaella Ambrosio, Massimo Granai, Serena Somma, Saliou Diop, Awa Oumar Touré, Evelyne May, Charles Henry Gattiollat, Joëlle Wiels, Yonis Ahmed, Martine Raphael, Lorenzo Leoncini, Cristiana Bellan, Pier Paolo Piccaluga
Objectives: Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in Western populations, being rarer in Asian and African people. It has been suggested that patients with CLL from Africa might have a more aggressive disease compared with white patients. In this study, we aimed to identify genetic factors that may account for this difference. Methods: We analyzed immunoglobulin heavy chain (IGH) genes' mutational status by performing next-generation sequencing in 25 Senegalese and 50 Italian patients with CLL...
November 20, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29158263/high-throughput-screening-identifies-fau-protein-as-a-regulator-of-mutant-cystic-fibrosis-transmembrane-conductance-regulator-channel
#18
Valeria Tomati, Emanuela Pesce, Emanuela Caci, Elvira Sondo, Paolo Scudieri, Monica Marini, Felice Amato, Giuseppe Castaldo, Roberto Ravazzolo, Luis Jv Galietta, Nicoletta Pedemonte
In cystic fibrosis (CF), deletion of phenylalanine 508 (F508del) in the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel causes misfolding and premature degradation. One possible approach to reducing CF's detrimental health effects could be the identification of proteins whose suppression rescues F508del-CFTR function in bronchial epithelial cells. However, searches for these potential targets have not yet been conducted, particularly in a relevant airway background using a functional readout...
November 20, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29149418/randomized-multicenter-trial-of-lateral-trendelenburg-versus-semirecumbent-body-position-for-the-prevention-of-ventilator-associated-pneumonia
#19
Gianluigi Li Bassi, Mauro Panigada, Otavio T Ranzani, Alberto Zanella, Lorenzo Berra, Massimo Cressoni, Vieri Parrini, Hassan Kandil, Giovanni Salati, Paola Selvaggi, Alessandro Amatu, Miquel Sanz-Moncosi, Emanuela Biagioni, Fernanda Tagliaferri, Mirella Furia, Giovanna Mercurio, Antonietta Costa, Tullio Manca, Simone Lindau, Jaksa Babel, Marco Cavana, Chiara Chiurazzi, Joan-Daniel Marti, Dario Consonni, Luciano Gattinoni, Antonio Pesenti, Janine Wiener-Kronish, Cecilia Bruschi, Andrea Ballotta, Pierpaolo Salsi, Sergio Livigni, Giorgio Iotti, Javier Fernandez, Massimo Girardis, Maria Barbagallo, Gabriella Moise, Massimo Antonelli, Maria Luisa Caspani, Antonella Vezzani, Patrick Meybohm, Vladimir Gasparovic, Edoardo Geat, Marcelo Amato, Michael Niederman, Theodor Kolobow, Antoni Torres
PURPOSE: The lateral Trendelenburg position (LTP) may hinder the primary pathophysiologic mechanism of ventilator-associated pneumonia (VAP). We investigated whether placing patients in the LTP would reduce the incidence of VAP in comparison with the semirecumbent position (SRP). METHODS: This was a randomized, multicenter, controlled study in invasively ventilated critically ill patients. Two preplanned interim analyses were performed. Patients were randomized to be placed in the LTP or the SRP...
November 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/29136531/long-term-effects-of-contrasting-tillage-on-soil-organic-carbon-nitrous-oxide-and-ammonia-emissions-in-a-mediterranean-vertisol-under-different-crop-sequences
#20
Giuseppe Badagliacca, Emilio Benítez, Gaetano Amato, Luigi Badalucco, Dario Giambalvo, Vito Armando Laudicina, Paolo Ruisi
This 2-year study aimed to verify whether the continuous application of no tillage (NT) for over 20years, in comparison with conventional tillage (CT), affects nitrous oxide (N2O) and ammonia (NH3) emissions from a Vertisol and, if so, whether such an effect varies with crop sequence (continuous wheat, WW and wheat after faba bean, FW). To shed light on the mechanisms involved in determining N-gas emissions, soil bulk density, water filled pore space (WFPS), some carbon (C) and nitrogen (N) pools, denitrifying enzyme activity (DEA), and nitrous oxide reductase gene abundance (nosZ gene) were also assessed at 0-15 and 15-30cm soil depth...
November 11, 2017: Science of the Total Environment
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