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Francois jardin

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https://www.readbyqxmd.com/read/27312795/recurrent-mutations-of-the-exportin-1-gene-xpo1-and-their-impact-on-selective-inhibitor-of-nuclear-export-compounds-sensitivity-in-primary-mediastinal-b-cell-lymphoma
#1
Fabrice Jardin, Anais Pujals, Laura Pelletier, Elodie Bohers, Vincent Camus, Sylvain Mareschal, Sydney Dubois, Brigitte Sola, Marlène Ochmann, François Lemonnier, Pierre-Julien Viailly, Philippe Bertrand, Catherine Maingonnat, Alexandra Traverse-Glehen, Philippe Gaulard, Diane Damotte, Richard Delarue, Corinne Haioun, Christian Argueta, Yosef Landesman, Gilles Salles, Jean-Philippe Jais, Martin Figeac, Christiane Copie-Bergman, Thierry Jo Molina, Jean Michel Picquenot, Marie Cornic, Thierry Fest, Noel Milpied, Emilie Lemasle, Aspasia Stamatoullas, Peter Moeller, Martin J S Dyer, Christer Sundstrom, Christian Bastard, Hervé Tilly, Karen Leroy
Primary mediastinal B-cell lymphoma (PMBL) is an entity of B-cell lymphoma distinct from the other molecular subtypes of diffuse large B-cell lymphoma (DLBCL). We investigated the prevalence, specificity, and clinical relevance of mutations of XPO1, which encodes a member of the karyopherin-β nuclear transporters, in a large cohort of PMBL. PMBL cases defined histologically or by gene expression profiling (GEP) were sequenced and the XPO1 mutational status was correlated to genetic and clinical characteristics...
September 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27301857/-louis-xiv-s-ginseng-shaping-of-knowledge-on-an-herbal-medicine-in-the-late-17th-and-the-early-18th-century-france
#2
Hye-Min Lee
This article aims to investigate the shaping of knowledge and discourse on ginseng, especially among physicians and botanists, since its introduction to France from the 17th century until the early 18th century. In France, knowledge on herbal medicine, including that of ginseng, was shaped under the influence of the modern state's policy and institution: mercantilism and the Académie royale des sciences. The knowledge of herbal medicine developed as an important part of the mercantilist policy supported systematically by the Académie...
April 2016: Ŭi Sahak
https://www.readbyqxmd.com/read/27060168/haploinsufficiency-for-nr3c1-the-gene-encoding-the-glucocorticoid-receptor-in-blastic-plasmacytoid-dendritic-cell-neoplasms
#3
Anouk Emadali, Neda Hoghoughi, Samuel Duley, Azadeh Hajmirza, Els Verhoeyen, Francois-Loic Cosset, Philippe Bertrand, Christophe Roumier, Anne Roggy, Céline Suchaud-Martin, Martine Chauvet, Sarah Bertrand, Sieme Hamaidia, Sophie Rousseaux, Véronique Josserand, Julie Charles, Isabelle Templier, Takahiro Maeda, Juliana Bruder-Costa, Laurence Chaperot, Joel Plumas, Marie-Christine Jacob, Thierry Bonnefoix, Sophie Park, Remy Gressin, Cornelis P Tensen, Cristina Mecucci, Elizabeth Macintyre, Dominique Leroux, Elisabeth Brambilla, Florence Nguyen-Khac, Isabelle Luquet, Dominique Penther, Christian Bastard, Fabrice Jardin, Christine Lefebvre, Francine Garnache, Mary B Callanan
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and highly aggressive leukemia for which knowledge on disease mechanisms and effective therapies are currently lacking. Only a handful of recurring genetic mutations have been identified and none is specific to BPDCN. In this study, through molecular cloning in an index case that presented a balanced t(3;5)(q21;q31) and molecular cytogenetic analyses in a further 46 cases, we identify monoallelic deletion of NR3C1 (5q31), encoding the glucocorticoid receptor (GCR), in 13 of 47 (28%) BPDCN patients...
June 16, 2016: Blood
https://www.readbyqxmd.com/read/26583761/effect-of-iterative-reconstruction-on-the-detection-of-systemic-sclerosis-related-interstitial-lung-disease-clinical-experience-in-55-patients
#4
François Pontana, Anne-Sophie Billard, Alain Duhamel, Bernhard Schmidt, Jean-Baptiste Faivre, Eric Hachulla, Régis Matran, Jacques Remy, Martine Remy-Jardin
PURPOSE: To evaluate the effect of iterative reconstruction on the depiction of systemic sclerosis-related interstitial lung disease (ILD) when the radiation dose is reduced by 60%. MATERIALS AND METHODS: This study was based on retrospective interpretation of prospectively acquired data over a 12-month period and approved by the institutional review board. The requirement to obtain informed consent was waived. Fifty-five chest computed tomographic (CT) examinations were performed in 38 women and 17 men (mean age, 55...
April 2016: Radiology
https://www.readbyqxmd.com/read/25648996/phenol-soluble-modulin-%C3%AE-induces-g2-m-phase-transition-delay-in-eukaryotic-hela-cells
#5
Martine Deplanche, Rachid Aref El-Aouar Filho, Ludmila Alekseeva, Emilie Ladier, Julien Jardin, Gwénaële Henry, Vasco Azevedo, Anderson Miyoshi, Laetitia Beraud, Frederic Laurent, Gerard Lina, François Vandenesch, Jean-Paul Steghens, Yves Le Loir, Michael Otto, Friedrich Götz, Nadia Berkova
Staphylococcus aureus is a gram-positive bacterium responsible for a wide range of infections. Host cell cycle alteration is a sophisticated mechanism used by pathogens to hijack the defense functions of host cells. We previously demonstrated that S. aureus MW2 (USA400) bacteria induced a G2/M phase transition delay in HeLa cells. We demonstrate here that this activity is triggered by culture supernatant compounds. Using size exclusion chromatography of the MW2 supernatant, followed by mass spectroscopy analysis of corresponding peaks, we identified phenol-soluble modulin α (PSMα) peptides as the likely candidates for this effect...
May 2015: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/25636413/impact-of-iterative-reconstruction-on-the-diagnosis-of-acute-pulmonary-embolism-pe-on-reduced-dose-chest-ct-angiograms
#6
François Pontana, Simon Henry, Alain Duhamel, Jean-Baptiste Faivre, Nunzia Tacelli, Julien Pagniez, Jacques Remy, Martine Remy-Jardin
PURPOSE: To evaluate the impact of iterative reconstruction on the detectability of clots. METHODS AND MATERIALS: Fifty-three patients were enrolled in a study comparing reduced-dose and full-dose images, available from the same dual-source data set. From each acquisition, three series of images were generated: (1) full-dose images (from both tubes), reconstructed with filtered back projection (FBP) (group 1; standard of reference), (2) reduced-dose images (from tube A only; 60 % dose reduction) reconstructed with FBP (group 2) and iterative reconstruction (SAFIRE) (group 3)...
April 2015: European Radiology
https://www.readbyqxmd.com/read/25474514/cxcl12-and-cxcr4-but-not-cxcr7-are-primarily-expressed-by-the-stroma-in-head-and-neck-squamous-cell-carcinoma
#7
Florian Clatot, Marie Cornic, Anca Berghian, Vinciane Marchand, Olivier Choussy, Faissal El Ouakif, Arnaud François, Philippe Ruminy, Sophie Laberge-Le-Couteulx, Jean-Michel Picquenot, Fabrice Jardin
The CXCL12/CXCR4 axis is involved in numerous models of metastatic dissemination, including head and neck squamous cell carcinoma (HNSCC). We assessed the relative expressions of CXCL12, CXCR4 and CXCR7 in the stroma and the tumour of HNSCC, and evaluated the methylation status of the CXCL12 promoter.Snap-frozen, HPV negative HNSCC samples were micro-dissected to isolate the tumoural and stromal compartments. The expression levels of CXCL12, CXCR4 and CXCR7 were assessed by qRT-PCR, and the methylation level of the CXCL12 promoter was evaluated by pyrosequencing...
January 2015: Pathology
https://www.readbyqxmd.com/read/25373456/copy-neutral-loss-of-heterozygosity-and-chromosome-gains-and-losses-are-frequent-in-gastrointestinal-stromal-tumors
#8
Nelson Lourenço, Zofia Hélias-Rodzewicz, Jean-Baptiste Bachet, Sabrina Brahimi-Adouane, Fabrice Jardin, Jeanne Tran van Nhieu, Frédérique Peschaud, Emmanuel Martin, Alain Beauchet, Frédéric Chibon, Jean-François Emile
BACKGROUND: A KIT gain of function mutation is present in 70% of gastrointestinal stromal tumors (GISTs) and the wild-type (WT) allele is deleted in 5 to 15% of these cases. The WT KIT is probably deleted during GIST progression. We aimed to identify the mechanism of WT KIT loss and to determine whether other genes are involved or affected. METHODS: Whole-genome SNP array analyses were performed in 22 GISTs with KIT exon 11 mutations, including 11 with WT loss, to investigate the mechanisms of WT allele deletion...
2014: Molecular Cancer
https://www.readbyqxmd.com/read/25316113/fine-tuned-characterization-of-staphylococcus-aureus-newbould-305-a-strain-associated-with-mild-and-chronic-mastitis-in-bovines
#9
Vincent Peton, Damien S Bouchard, Sintia Almeida, Lucie Rault, Hélène Falentin, Julien Jardin, Gwénaël Jan, David Hernandez, Patrice François, Jacques Schrenzel, Vasco Azevedo, Anderson Miyoshi, Nadia Berkova, Sergine Even, Yves Le Loir
S. aureus is a major aetiological agent of ruminant mastitis worldwide. The chronic nature of S. aureus mastitis makes it difficult to cure and prone to resurgence. In order to identify the bacterial factors involved in this chronicity, Newbould 305 (N305), a strain that can reproducibly induce mild and chronic mastitis in an experimental setting, was characterized in depth. We employed genomic and proteomic techniques combined with phenotype characterization, in order to comprehensively analyse N305. The results were compared with data obtained on S...
2014: Veterinary Research
https://www.readbyqxmd.com/read/24481760/thoracic-applications-of-dual-energy
#10
REVIEW
Martine Remy-Jardin, Jean-Baptiste Faivre, Francois Pontana, Francesco Molinari, Nunzia Tacelli, Jacques Remy
Computed tomography (CT) is the core imaging modality for the evaluation of thoracic disorders. With the recently developed dual-energy CT (DECT) technique, the clinical utility of CT in the management of pulmonary diseases can be expanded. The most actively investigated principle of dual energy is material decomposition based on attenuation differences at different energy levels. This technique provides two key insights into lung physiology, that is, regional perfusion and ventilation. This functional information is obtained in addition to morphologic information because high-resolution thoracic anatomy is entirely preserved on dual-energy thoracic CT...
February 2014: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/24463406/left-atrial-volume-in-chronic-obstructive-pulmonary-disease
#11
Lucie Cassagnes, François Pontana, Francesco Molinari, Jean-Baptiste Faivre, Teresa Santangelo, Emmanuela Algeri, Alain Duhamel, Jacques Remy, Martine Remy-Jardin
PURPOSE: The aim of the study was to evaluate left atrial (LA) volume in smokers according to the severity of emphysema, with the objective of providing indirect evidence of reduced pulmonary venous return due to capillary destruction. MATERIALS AND METHODS: A total of 121 smokers underwent a high-pitch and high-temporal resolution computed tomography (CT) angiographic examination, enabling quantification of emphysema, total lung volume, and LA volume measurements normalized to body surface area...
July 2014: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/24387976/the-gene-expression-profile-of-inflammatory-hypoxic-and-metabolic-genes-predicts-the-metastatic-spread-of-human-head-and-neck-squamous-cell-carcinoma
#12
Florian Clatot, Sophie Gouérant, Sylvain Mareschal, Marie Cornic, Anca Berghian, Olivier Choussy, Faissal El Ouakif, Arnaud François, Magalie Bénard, Philippe Ruminy, Jean-Michel Picquenot, Fabrice Jardin
OBJECTIVES: To assess the prognostic value of the expression profile of the main genes implicated in hypoxia, glucose and lactate metabolism, inflammation, angiogenesis and extracellular matrix interactions for the metastatic spread of head and neck squamous cell carcinoma. PATIENTS AND METHODS: Using a high-throughput qRT-PCR, we performed an unsupervised clustering analysis based on the expression of 42 genes for 61 patients. Usual prognostic factors and clustering analysis results were related to metastasis free survival...
March 2014: Oral Oncology
https://www.readbyqxmd.com/read/24267717/new-insights-in-thromboembolic-disease
#13
Martine Remy-Jardin, François Pontana, Jean-Baptiste Faivre, Francesco Molinari, Julien Pagniez, Suonita Khung, Jacques Remy
This article highlights new areas of interest in the management of patients with acute pulmonary embolism, with the objective of alerting radiologists about necessary updates for daily practice.
January 2014: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/23793896/characterization-of-volatile-organic-compounds-emitted-by-barley-hordeum-vulgare-l-roots-and-their-attractiveness-to-wireworms
#14
Aurélie Gfeller, Morgan Laloux, Fanny Barsics, Djamel Edine Kati, Eric Haubruge, Patrick du Jardin, François J Verheggen, Georges Lognay, Jean-Paul Wathelet, Marie-Laure Fauconnier
Root volatile organic compounds (VOCs), their chemistry and ecological functions have garnered less attention than aboveground emitted plant VOCs. We report here on the identification of VOCs emitted by barley roots (Hordeum vulgare L.). Twenty nine VOCs were identified from isolated 21-d-old roots. The detection was dependent on the medium used for root cultivation. We identified 24 VOCs from 7-d-old roots when plants were cultivated on sterile Hoagland gelified medium, 33 when grown on sterile vermiculite, and 34 on non-sterile vermiculite...
August 2013: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/23615574/high-pitch-dual-source-chest-computed-tomography-angiography-without-electrocardiographic-synchronization-evaluation-of-cardiac-motion-artifacts-on-pulmonary-circulation
#15
Nunzia Tacelli, Christine Darchis, François Pontana, Jean-Baptiste Faivre, Valérie Deken, Alain Duhamel, Colm Murphy, Jacques Remy, Martine Remy-Jardin
PURPOSE: To evaluate the frequency and severity of cardiac motion artifacts on high-pitch, dual-source computed tomography angiograms of the chest. MATERIALS AND METHODS: One hundred consecutive patients underwent a non-electrocardiogram-gated, dual-source chest computed tomography examination with high pitch and high temporal resolution. RESULTS: The mean (±SD) duration of data acquisition was 0.9 (±0.07) seconds and the mean (±SD) heart rate was 78...
November 2013: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/23364750/improvement-of-ylang-ylang-essential-oil-characterization-by-gc%C3%A3-gc-tofms
#16
Michał Brokl, Marie-Laure Fauconnier, Céline Benini, Georges Lognay, Patrick du Jardin, Jean-François Focant
A single fraction of essential oil can often contain hundreds of compounds. Despite of the technical improvements and the enhanced selectivity currently offered by the state-of-the-art gas chromatography (GC) and mass spectrometry (MS) instruments, the complexity of essential oils is frequently underestimated. Comprehensive two-dimensional GC coupled to time-of-flight MS (GC×GC-TOFMS) was used to improve the chemical characterization of ylang-ylang essential oil fractions recently reported in a previous one-dimensional (1D) GC study...
2013: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/23319663/spectral-optimization-of-chest-ct-angiography-with-reduced-iodine-load-experience-in-80-patients-evaluated-with-dual-source-dual-energy-ct
#17
Marie-Aurélie Delesalle, François Pontana, Alain Duhamel, Jean-Baptiste Faivre, Thomas Flohr, Nunzia Tacelli, Jacques Remy, Martine Remy-Jardin
PURPOSE: To determine the energy levels that provide optimal imaging of thoracic circulation at dual-energy computed tomographic (CT) angiography with reduced iodine load in comparison with a standard technique. MATERIALS AND METHODS: The institutional review board approved the study with waiver of patient consent. Eighty patients underwent a dual-source, dual-energy CT examination after administration of low-concentration contrast material (170 mg of iodine per milliliter), and eight series of images were reconstructed, including the original polychromatic images at 80 and 140 kV and six series of virtual monochromatic spectral images at 50, 60, 70, 80, 90, and 100 keV...
April 2013: Radiology
https://www.readbyqxmd.com/read/23297336/reduced-dose-low-voltage-chest-ct-angiography-with-sinogram-affirmed-iterative-reconstruction-versus-standard-dose-filtered-back-projection
#18
François Pontana, Julien Pagniez, Alain Duhamel, Thomas Flohr, Jean-Baptiste Faivre, Colm Murphy, Jacques Remy, Martine Remy-Jardin
PURPOSE: To evaluate image quality of low-voltage chest computed tomographic (CT) angiography with raw data-based iterative reconstruction (sonogram-affirmed iterative reconstruction) in comparison with image quality of standard-dose standard-voltage filtered back projection (FBP) CT. MATERIALS AND METHODS: This prospective study was approved by the institutional review board, and the informed consent requirement was waived. Eighty consecutive patients who were referred for follow-up chest CT angiography underwent reduced-dose CT (hereafter, T2 examination) under technical conditions similar to those of the initial examination (hereafter, T1 examination), except the voltage selection was reduced by 20 kV with adaptation of the tube current to ensure a 50% reduction in CT dose index, and regular FBP was replaced by iterative reconstruction with sonogram-affirmed iterative reconstruction...
May 2013: Radiology
https://www.readbyqxmd.com/read/22980847/quantitative-and-qualitative-variability-of-the-caseinolytic-potential-of-different-strains-of-pseudomonas-fluorescens-implications-for-the-stability-of-casein-micelles-of-uht-milks-during-their-storage
#19
François Baglinière, Gaëlle Tanguy, Julien Jardin, Aurélie Matéos, Valérie Briard, Florence Rousseau, Benoît Robert, Eric Beaucher, Gérard Humbert, Annie Dary, Jean Luc Gaillard, Caroline Amiel, Frédéric Gaucheron
Pseudomonas fluorescens grows at low temperature and produces thermo-resistant protease(s) that can destabilize UHT (Ultra High Temperature) milk during its storage. The consequences of contamination of microfiltered milk with 9 strains of P. fluorescens on the stability of the corresponding UHT milk during storage had been investigated in this study. The strains were classified in two groups according to their ability to destabilize UHT milk. For the group of highly destabilizing strains, sedimentations of UHT milks, low values to phosphate test and the presence of aggregates were observed...
December 15, 2012: Food Chemistry
https://www.readbyqxmd.com/read/22696000/ultrafast-imaging-of-the-entire-chest-without-ecg-synchronisation-or-beta-blockade-to-what-extent-can-we-analyse-the-coronary-arteries
#20
Maxime de Malherbe, Alain Duhamel, Nunzia Tacelli, Anne-Lise Hachulla, François Pontana, Jean-Baptiste Faivre, Jacques Remy, Martine Remy-Jardin
OBJECTIVES: To evaluate the accessibility of coronary arteries from chest CT examinations acquired without ECG gating or beta-blockade. MATERIALS AND METHODS: Two hundred forty-two patients (median heart rate: 81.7 bpm) underwent a non-ECG-gated CT examination with high pitch and high temporal resolution. Image analysis was obtained by consensus between two readers. RESULTS: The percentage of accessible segments was 88% at the proximal level (i...
February 2012: Insights Into Imaging
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