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Francois jardin

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https://www.readbyqxmd.com/read/29523554/lysosomal-cholesterol-hydrolysis-couples-efferocytosis-to-anti-inflammatory-oxysterol-production
#1
Manon Viaud, Stoyan Ivanov, Nemanja Vujic, Madalina Duta-Mare, Lazaro-Emilio Aira, Thibault Barouillet, Elsa Garcia, François Orange, Isabelle Dugail, Isabelle Hainault, Christian Stehlik, Sandrine Marchetti, Laurent Boyer, Rodolphe Guinamard, Fabienne Foufelle, Andrea E Bochem, Kees G Hovingh, Edward B Thorp, Emmanuel L Gautier, Dagmar Kratky, Paul A Da Silva-Jardine, Laurent Yvan-Charvet
<u>Rationale:</u> Macrophages face a substantial amount of cholesterol following the ingestion of apoptotic cells and the lysosomal acid lipase (LIPA) has a major role in hydrolyzing cholesteryl esters in the endocytic compartment. <u>Objective:</u> Here, we directly investigated the role of LIPA-mediated clearance of apoptotic cells both in vitro and in vivo. <u>Methods and Results:</u> We show that LIPA inhibition causes a defective efferocytic response due to impaired generation of 25-OHC and 27-OHC...
March 9, 2018: Circulation Research
https://www.readbyqxmd.com/read/29473343/central-nervous-system-relapse-in-patients-over-80-years-with-diffuse-large-b-cell-lymphoma-an-analysis-of-two-lysa-studies
#2
Aurélie Cabannes-Hamy, Frederic Peyrade, Fabrice Jardin, Jean-François Emile, Vincent Delwail, Nicolas Mounier, Corinne Haioun, Aurore Perrot, Olivier Fitoussi, Diane Lara, Richard Delarue, Marc André, Fritz Offner, Hervé Ghesquières, Laurent Pascal, Carole Soussain, Julien Lazarovici, Jean-Marc Schiano, Philippe Gaulard, Hervé Tilly, Catherine Thieblemont
CNS relapse is reported in 2-5% of diffuse large B-cell lymphoma (DLBCL) patients, dramatically decreasing overall survival (OS). Very few studies address incidence and risk factors of CNS relapse in very elderly patients, a challenging population to treat given their commonly associated comorbidities. A retrospective analysis was performed of 270 DLBCL patients >80 years treated between 2004 and 2013 in two multicentre phase II LYSA trials (LNH03-7B, LNH09-7B) evaluating the addition of rituximab or ofatumumab to mini-CHOP as front-line therapy...
February 23, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29246248/factors-associated-with-the-6-minute-walk-distance-in-patients-with-systemic-sclerosis
#3
Sébastien Sanges, Jonathan Giovannelli, Vincent Sobanski, Sandrine Morell-Dubois, Hélène Maillard, Marc Lambert, Céline Podevin, Nicolas Lamblin, Pascal De Groote, Jean-François Bervar, Thierry Perez, Régis Matran, Martine Rémy-Jardin, Pierre-Yves Hatron, Éric Hachulla, David Launay
BACKGROUND: There is an ongoing debate regarding the relevance of the 6-minute walking distance (6MWD) in systemic sclerosis (SSc) assessment, widely used as a usual test in these patients as well as an outcome measure in clinical trials. In this work, we aimed to assess the associations between the 6MWD and various disease parameters in patients with SSc. METHODS: Consecutive patients followed in our SSc National Reference Centre were included in this cross-sectional study if they fulfilled the 2013 American College of Rheumatology/European League Against Rheumatism criteria for SSc...
December 15, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28490091/physico-chemical-characterization-of-dairy-gel-obtained-by-a-proteolytic-extract-from-calotropis-procera-a-comparison-with-chymosin
#4
Issa Ado Rayanatou, ElHadji Gounga Mahamadou, Gilles Garric, Marielle Harel-Oger, Arlette Leduc, Julien Jardin, Valérie Briard-Bion, Chantal Cauty, Hassane Adakal, Jean François Grongnet, Frédéric Gaucheron
Chymosin is the major enzyme used in cheesemaking but latex enzymes are also used. The aim of this work was to characterize the composition and the structure of dairy gel obtained by an extract of Calotropis procera leaves in comparison with those obtained by chymosin. The biochemical and mineral compositions of the curds and the cheese yields obtained by using Calotropis procera extract or chymosin were relatively similar. Quantitative and qualitative evaluations of proteolysis after milk coagulation, determined by the non-protein nitrogen content and chromatography coupled to mass spectrometry, indicated that Calotropis procera extract was more proteolytic than chymosin and that κ-casein was proteolyzed...
October 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28372152/ser2-from-serratia-liquefaciens-l53-a-new-heat-stable-protease-able-to-destabilize-uht-milk-during-its-storage
#5
François Baglinière, Gaëlle Tanguy, Rafael Locatelli Salgado, Julien Jardin, Florence Rousseau, Benoît Robert, Marielle Harel-Oger, Maria Cristina Dantas Vanetti, Frédéric Gaucheron
The heat-stable protease Ser2 is secreted by the species Serratia liquefaciens, a psychrotrophic bacteria frequently found in raw milk. To understand the physicochemical modifications of casein micelles induced by Ser2 and to confirm its implication in UHT milk destabilization, the enzyme was purified and added to microfiltered raw milk before UHT treatment. UHT milk destabilization was investigated during 90days of storage. A visual destabilization appeared after 8days of storage with the presence of sediment...
August 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28041583/combination-of-ofatumumab-and-reduced-dose-chop-for-diffuse-large-b-cell-lymphomas-in-patients-aged-80-years-or-older-an-open-label-multicentre-single-arm-phase-2-trial-from-the-lysa-group
#6
Frédéric Peyrade, Serge Bologna, Vincent Delwail, Jean François Emile, Laurent Pascal, Christophe Fermé, Jean-Marc Schiano, Bertrand Coiffier, Bernadette Corront, Hassan Farhat, Christophe Fruchart, Herve Ghesquieres, Margaret Macro, Hervé Tilly, Bachra Choufi, Richard Delarue, Olivier Fitoussi, Jean Gabarre, Corinne Haioun, Fabrice Jardin
BACKGROUND: In 2011 we reported a rituximab plus miniCHOP (reduced-dose cyclophosphamide, doxorubicin, vincristine, and prednisone) combination for patients older than 80 years with diffuse large B-cell lymphoma (DLBCL). The 2-year overall survival was 59% (95% CI 49-67) with an excess of early toxicity. To improve those results we tested the same chemotherapy protocol in combination with ofatumumab and a pre-phase treatment. METHODS: For this open-label, multicentre, single-group, phase 2 trial, we recruited patients older than 80 years with untreated histologically-proven CD20-positive DLBCL, Ann Arbor stage I to IV, from 41 academic and hospital centres in France and Belgium...
January 2017: Lancet Haematology
https://www.readbyqxmd.com/read/27312795/recurrent-mutations-of-the-exportin-1-gene-xpo1-and-their-impact-on-selective-inhibitor-of-nuclear-export-compounds-sensitivity-in-primary-mediastinal-b-cell-lymphoma
#7
Fabrice Jardin, Anais Pujals, Laura Pelletier, Elodie Bohers, Vincent Camus, Sylvain Mareschal, Sydney Dubois, Brigitte Sola, Marlène Ochmann, François Lemonnier, Pierre-Julien Viailly, Philippe Bertrand, Catherine Maingonnat, Alexandra Traverse-Glehen, Philippe Gaulard, Diane Damotte, Richard Delarue, Corinne Haioun, Christian Argueta, Yosef Landesman, Gilles Salles, Jean-Philippe Jais, Martin Figeac, Christiane Copie-Bergman, Thierry Jo Molina, Jean Michel Picquenot, Marie Cornic, Thierry Fest, Noel Milpied, Emilie Lemasle, Aspasia Stamatoullas, Peter Moeller, Martin J S Dyer, Christer Sundstrom, Christian Bastard, Hervé Tilly, Karen Leroy
Primary mediastinal B-cell lymphoma (PMBL) is an entity of B-cell lymphoma distinct from the other molecular subtypes of diffuse large B-cell lymphoma (DLBCL). We investigated the prevalence, specificity, and clinical relevance of mutations of XPO1, which encodes a member of the karyopherin-β nuclear transporters, in a large cohort of PMBL. PMBL cases defined histologically or by gene expression profiling (GEP) were sequenced and the XPO1 mutational status was correlated to genetic and clinical characteristics...
September 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27301857/-louis-xiv-s-ginseng-shaping-of-knowledge-on-an-herbal-medicine-in-the-late-17th-and-the-early-18th-century-france
#8
Hye-Min Lee
This article aims to investigate the shaping of knowledge and discourse on ginseng, especially among physicians and botanists, since its introduction to France from the 17th century until the early 18th century. In France, knowledge on herbal medicine, including that of ginseng, was shaped under the influence of the modern state's policy and institution: mercantilism and the Académie royale des sciences. The knowledge of herbal medicine developed as an important part of the mercantilist policy supported systematically by the Académie...
April 2016: Ŭi Sahak
https://www.readbyqxmd.com/read/27060168/haploinsufficiency-for-nr3c1-the-gene-encoding-the-glucocorticoid-receptor-in-blastic-plasmacytoid-dendritic-cell-neoplasms
#9
Anouk Emadali, Neda Hoghoughi, Samuel Duley, Azadeh Hajmirza, Els Verhoeyen, Francois-Loic Cosset, Philippe Bertrand, Christophe Roumier, Anne Roggy, Céline Suchaud-Martin, Martine Chauvet, Sarah Bertrand, Sieme Hamaidia, Sophie Rousseaux, Véronique Josserand, Julie Charles, Isabelle Templier, Takahiro Maeda, Juliana Bruder-Costa, Laurence Chaperot, Joel Plumas, Marie-Christine Jacob, Thierry Bonnefoix, Sophie Park, Remy Gressin, Cornelis P Tensen, Cristina Mecucci, Elizabeth Macintyre, Dominique Leroux, Elisabeth Brambilla, Florence Nguyen-Khac, Isabelle Luquet, Dominique Penther, Christian Bastard, Fabrice Jardin, Christine Lefebvre, Francine Garnache, Mary B Callanan
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and highly aggressive leukemia for which knowledge on disease mechanisms and effective therapies are currently lacking. Only a handful of recurring genetic mutations have been identified and none is specific to BPDCN. In this study, through molecular cloning in an index case that presented a balanced t(3;5)(q21;q31) and molecular cytogenetic analyses in a further 46 cases, we identify monoallelic deletion of NR3C1 (5q31), encoding the glucocorticoid receptor (GCR), in 13 of 47 (28%) BPDCN patients...
June 16, 2016: Blood
https://www.readbyqxmd.com/read/26583761/effect-of-iterative-reconstruction-on-the-detection-of-systemic-sclerosis-related-interstitial-lung-disease-clinical-experience-in-55-patients
#10
François Pontana, Anne-Sophie Billard, Alain Duhamel, Bernhard Schmidt, Jean-Baptiste Faivre, Eric Hachulla, Régis Matran, Jacques Remy, Martine Remy-Jardin
PURPOSE: To evaluate the effect of iterative reconstruction on the depiction of systemic sclerosis-related interstitial lung disease (ILD) when the radiation dose is reduced by 60%. MATERIALS AND METHODS: This study was based on retrospective interpretation of prospectively acquired data over a 12-month period and approved by the institutional review board. The requirement to obtain informed consent was waived. Fifty-five chest computed tomographic (CT) examinations were performed in 38 women and 17 men (mean age, 55...
April 2016: Radiology
https://www.readbyqxmd.com/read/25648996/phenol-soluble-modulin-%C3%AE-induces-g2-m-phase-transition-delay-in-eukaryotic-hela-cells
#11
Martine Deplanche, Rachid Aref El-Aouar Filho, Ludmila Alekseeva, Emilie Ladier, Julien Jardin, Gwénaële Henry, Vasco Azevedo, Anderson Miyoshi, Laetitia Beraud, Frederic Laurent, Gerard Lina, François Vandenesch, Jean-Paul Steghens, Yves Le Loir, Michael Otto, Friedrich Götz, Nadia Berkova
Staphylococcus aureus is a gram-positive bacterium responsible for a wide range of infections. Host cell cycle alteration is a sophisticated mechanism used by pathogens to hijack the defense functions of host cells. We previously demonstrated that S. aureus MW2 (USA400) bacteria induced a G2/M phase transition delay in HeLa cells. We demonstrate here that this activity is triggered by culture supernatant compounds. Using size exclusion chromatography of the MW2 supernatant, followed by mass spectroscopy analysis of corresponding peaks, we identified phenol-soluble modulin α (PSMα) peptides as the likely candidates for this effect...
May 2015: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/25636413/impact-of-iterative-reconstruction-on-the-diagnosis-of-acute-pulmonary-embolism-pe-on-reduced-dose-chest-ct-angiograms
#12
François Pontana, Simon Henry, Alain Duhamel, Jean-Baptiste Faivre, Nunzia Tacelli, Julien Pagniez, Jacques Remy, Martine Remy-Jardin
PURPOSE: To evaluate the impact of iterative reconstruction on the detectability of clots. METHODS AND MATERIALS: Fifty-three patients were enrolled in a study comparing reduced-dose and full-dose images, available from the same dual-source data set. From each acquisition, three series of images were generated: (1) full-dose images (from both tubes), reconstructed with filtered back projection (FBP) (group 1; standard of reference), (2) reduced-dose images (from tube A only; 60 % dose reduction) reconstructed with FBP (group 2) and iterative reconstruction (SAFIRE) (group 3)...
April 2015: European Radiology
https://www.readbyqxmd.com/read/25474514/cxcl12-and-cxcr4-but-not-cxcr7-are-primarily-expressed-by-the-stroma-in-head-and-neck-squamous-cell-carcinoma
#13
Florian Clatot, Marie Cornic, Anca Berghian, Vinciane Marchand, Olivier Choussy, Faissal El Ouakif, Arnaud François, Philippe Ruminy, Sophie Laberge-Le-Couteulx, Jean-Michel Picquenot, Fabrice Jardin
The CXCL12/CXCR4 axis is involved in numerous models of metastatic dissemination, including head and neck squamous cell carcinoma (HNSCC). We assessed the relative expressions of CXCL12, CXCR4 and CXCR7 in the stroma and the tumour of HNSCC, and evaluated the methylation status of the CXCL12 promoter.Snap-frozen, HPV negative HNSCC samples were micro-dissected to isolate the tumoural and stromal compartments. The expression levels of CXCL12, CXCR4 and CXCR7 were assessed by qRT-PCR, and the methylation level of the CXCL12 promoter was evaluated by pyrosequencing...
January 2015: Pathology
https://www.readbyqxmd.com/read/25373456/copy-neutral-loss-of-heterozygosity-and-chromosome-gains-and-losses-are-frequent-in-gastrointestinal-stromal-tumors
#14
Nelson Lourenço, Zofia Hélias-Rodzewicz, Jean-Baptiste Bachet, Sabrina Brahimi-Adouane, Fabrice Jardin, Jeanne Tran van Nhieu, Frédérique Peschaud, Emmanuel Martin, Alain Beauchet, Frédéric Chibon, Jean-François Emile
BACKGROUND: A KIT gain of function mutation is present in 70% of gastrointestinal stromal tumors (GISTs) and the wild-type (WT) allele is deleted in 5 to 15% of these cases. The WT KIT is probably deleted during GIST progression. We aimed to identify the mechanism of WT KIT loss and to determine whether other genes are involved or affected. METHODS: Whole-genome SNP array analyses were performed in 22 GISTs with KIT exon 11 mutations, including 11 with WT loss, to investigate the mechanisms of WT allele deletion...
2014: Molecular Cancer
https://www.readbyqxmd.com/read/25316113/fine-tuned-characterization-of-staphylococcus-aureus-newbould-305-a-strain-associated-with-mild-and-chronic-mastitis-in-bovines
#15
Vincent Peton, Damien S Bouchard, Sintia Almeida, Lucie Rault, Hélène Falentin, Julien Jardin, Gwénaël Jan, David Hernandez, Patrice François, Jacques Schrenzel, Vasco Azevedo, Anderson Miyoshi, Nadia Berkova, Sergine Even, Yves Le Loir
S. aureus is a major aetiological agent of ruminant mastitis worldwide. The chronic nature of S. aureus mastitis makes it difficult to cure and prone to resurgence. In order to identify the bacterial factors involved in this chronicity, Newbould 305 (N305), a strain that can reproducibly induce mild and chronic mastitis in an experimental setting, was characterized in depth. We employed genomic and proteomic techniques combined with phenotype characterization, in order to comprehensively analyse N305. The results were compared with data obtained on S...
2014: Veterinary Research
https://www.readbyqxmd.com/read/24481760/thoracic-applications-of-dual-energy
#16
REVIEW
Martine Remy-Jardin, Jean-Baptiste Faivre, Francois Pontana, Francesco Molinari, Nunzia Tacelli, Jacques Remy
Computed tomography (CT) is the core imaging modality for the evaluation of thoracic disorders. With the recently developed dual-energy CT (DECT) technique, the clinical utility of CT in the management of pulmonary diseases can be expanded. The most actively investigated principle of dual energy is material decomposition based on attenuation differences at different energy levels. This technique provides two key insights into lung physiology, that is, regional perfusion and ventilation. This functional information is obtained in addition to morphologic information because high-resolution thoracic anatomy is entirely preserved on dual-energy thoracic CT...
February 2014: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/24463406/left-atrial-volume-in-chronic-obstructive-pulmonary-disease
#17
Lucie Cassagnes, François Pontana, Francesco Molinari, Jean-Baptiste Faivre, Teresa Santangelo, Emmanuela Algeri, Alain Duhamel, Jacques Remy, Martine Remy-Jardin
PURPOSE: The aim of the study was to evaluate left atrial (LA) volume in smokers according to the severity of emphysema, with the objective of providing indirect evidence of reduced pulmonary venous return due to capillary destruction. MATERIALS AND METHODS: A total of 121 smokers underwent a high-pitch and high-temporal resolution computed tomography (CT) angiographic examination, enabling quantification of emphysema, total lung volume, and LA volume measurements normalized to body surface area...
July 2014: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/24387976/the-gene-expression-profile-of-inflammatory-hypoxic-and-metabolic-genes-predicts-the-metastatic-spread-of-human-head-and-neck-squamous-cell-carcinoma
#18
Florian Clatot, Sophie Gouérant, Sylvain Mareschal, Marie Cornic, Anca Berghian, Olivier Choussy, Faissal El Ouakif, Arnaud François, Magalie Bénard, Philippe Ruminy, Jean-Michel Picquenot, Fabrice Jardin
OBJECTIVES: To assess the prognostic value of the expression profile of the main genes implicated in hypoxia, glucose and lactate metabolism, inflammation, angiogenesis and extracellular matrix interactions for the metastatic spread of head and neck squamous cell carcinoma. PATIENTS AND METHODS: Using a high-throughput qRT-PCR, we performed an unsupervised clustering analysis based on the expression of 42 genes for 61 patients. Usual prognostic factors and clustering analysis results were related to metastasis free survival...
March 2014: Oral Oncology
https://www.readbyqxmd.com/read/24267717/new-insights-in-thromboembolic-disease
#19
Martine Remy-Jardin, François Pontana, Jean-Baptiste Faivre, Francesco Molinari, Julien Pagniez, Suonita Khung, Jacques Remy
This article highlights new areas of interest in the management of patients with acute pulmonary embolism, with the objective of alerting radiologists about necessary updates for daily practice.
January 2014: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/23793896/characterization-of-volatile-organic-compounds-emitted-by-barley-hordeum-vulgare-l-roots-and-their-attractiveness-to-wireworms
#20
Aurélie Gfeller, Morgan Laloux, Fanny Barsics, Djamel Edine Kati, Eric Haubruge, Patrick du Jardin, François J Verheggen, Georges Lognay, Jean-Paul Wathelet, Marie-Laure Fauconnier
Root volatile organic compounds (VOCs), their chemistry and ecological functions have garnered less attention than aboveground emitted plant VOCs. We report here on the identification of VOCs emitted by barley roots (Hordeum vulgare L.). Twenty nine VOCs were identified from isolated 21-d-old roots. The detection was dependent on the medium used for root cultivation. We identified 24 VOCs from 7-d-old roots when plants were cultivated on sterile Hoagland gelified medium, 33 when grown on sterile vermiculite, and 34 on non-sterile vermiculite...
August 2013: Journal of Chemical Ecology
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