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Roch Houot, Emmanuel Bachy, Guillaume Cartron, François-Xavier Gros, Franck Morschhauser, Lucie Oberic, Thomas Gastinne, Pierre Feugier, Rémy Duléry, Catherine Thieblemont, Magalie Joris, Fabrice Jardin, Sylvain Choquet, Olivier Casasnovas, Gabriel Brisou, Morgane Cheminant, Jacques-Olivier Bay, Francisco Llamas Gutierrez, Cédric Menard, Karin Tarte, Marie-Hélène Delfau, Cédric Portugues, Emmanuel Itti, Xavier Palard-Novello, Paul Blanc-Durand, Yassine Al Tabaa, Clément Bailly, Camille Laurent, François Lemonnier
No abstract text is available yet for this article.
October 2023: Nature Medicine
#2
JOURNAL ARTICLE
Francois Cherifi, François Gernier, Fabrice Jardin, Sophie Lefevre-Arbogast, Etienne Bastien, Justine Lequesne, Olivier Rigal, Florian Quilan, Bénédicte Clarisse, Jean-Michel Grellard, Giulia Binarelli, Marie Fernette, Marie Lange, Doriane Richard, Adeline Morel, Bénédicte Griffon, Louis-Ferdinand Pepin, Alexandra Leconte, Audrey Faveyrial, Marianne Leheurteur, Bérengère Beauplet, Florence Joly
INTRODUCTION: The Coronavirus (COVID-19) pandemic and its associated health restrictions have harmed the population psychologically. We aimed to compare the post-traumatic stress disorder (PTSD) symptoms and Quality of Life (QoL) in older French patients with cancer to the younger ones. MATERIALS AND METHODS: This longitudinal multicenter study named COVIPACT began in April 2020 during the first French lockdown and has included 579 outpatients receiving treatment for a solid or hematological malignancy...
September 25, 2023: Journal of Geriatric Oncology
#3
JOURNAL ARTICLE
Roch Houot, Emmanuel Bachy, Guillaume Cartron, François-Xavier Gros, Franck Morschhauser, Lucie Oberic, Thomas Gastinne, Pierre Feugier, Rémy Duléry, Catherine Thieblemont, Magalie Joris, Fabrice Jardin, Sylvain Choquet, Olivier Casasnovas, Gabriel Brisou, Morgane Cheminant, Jacques-Olivier Bay, Francisco Llamas Gutierrez, Cédric Menard, Karin Tarte, Marie-Hélène Delfau, Cédric Portugues, Emmanuel Itti, Xavier Palard-Novello, Paul Blanc-Durand, Yassine Al Tabaa, Clément Bailly, Camille Laurent, François Lemonnier
Axicabtagene ciloleucel (axi-cel) demonstrated superior efficacy compared to standard of care as second-line therapy in patients with high-risk relapsed/refractory (R/R) large B cell lymphoma (LBCL) considered eligible for autologous stem cell transplantation (ASCT); however, in clinical practice, roughly half of patients with R/R LBCL are deemed unsuitable candidates for ASCT. The efficacy of axi-cel remains to be ascertained in transplant-ineligible patients. ALYCANTE, an open-label, phase 2 study, evaluated axi-cel as a second-line therapy in 62 patients with R/R LBCL who were considered ineligible for ASCT...
September 14, 2023: Nature Medicine
#4
REVIEW
Roch Houot, Jacques-Olivier Bay, Patrice Chevallier, Sylvain Choquet, Luc-Matthieu Fornecker, Jean-Christophe Ianotto, Arnaud Jaccard, Fabrice Jardin, Laurence Legros, François Lemonnier, Sophie Park, Laurent Pascal, Carole Soussain, Emmanuel Gyan
The French hospital system crises are constantly forcing the heads of departments to adapt and find solutions for maintaining optimal patient care in a context of staff shortage. Facing these challenges, we had the desire to create a community of department heads capable of helping each other, sharing their experiences, relying on collective intelligence and, ultimately, contributing to rebuilding their hospitals from the bottom up. In this respect, we arranged a two-day seminar, which brought together fourteen heads of hematology departments who share the same desire to challenge their organizations with a collaborative approach and make them evolve...
July 26, 2023: Bulletin du Cancer
#5
COMMENT
Cédric Gil-Jardiné, Jean-François Payen, Rémy Bernard, Xavier Bobbia, Pierre Bouzat, Pierre Catoire, Anthony Chauvin, Yann-Erick Claessens, Bénédicte Douay, Xavier Dubucs, Damien Galanaud, Tobias Gauss, Jean-Yves Gauvrit, Thomas Geeraerts, Bertrand Glize, Sybille Goddet, Anne Godier, Pierrick Le Borgne, Geoffroy Rousseau, Vincent Sapin, Lionel Velly, Damien Viglino, Bernard Vigue, Philippe Cuvillon, Denis Frasca, Pierre-Géraud Claret
OBJECTIVE: To develop a multidisciplinary French reference that addresses initial pre- and in-hospital management of a mild traumatic brain injury patient. DESIGN: A panel of 22 experts was formed on request from the French Society of Emergency Medicine (SFMU) and the French Society of Anaesthesiology and Critical Care Medicine (SFAR). A policy of declaration and monitoring of links of interest was applied and respected throughout the process of producing the guidelines...
August 2023: Anaesthesia, Critical Care & Pain Medicine
#6
JOURNAL ARTICLE
Isabelle R Jardine, Hannah E Christie, Kate Oetsch, Angelo Sabag, Meredith Kennedy, Barbara J Meyer, Monique E Francois
Maintaining blood glucose within the target range is the primary treatment goal for women with gestational diabetes mellitus (GDM). Foods with low glycaemic loads are recommended in clinical practice; however, the relative importance of other key lifestyle variables is unexplored. This pilot study explored the associations of glycaemic load, carbohydrates and physical activity parameters on blood glucose concentrations in free-living women with GDM. Twenty-nine women (28-30 weeks gestation, 34 ± 4 years) with GDM were enrolled...
April 19, 2023: Nutrients
#7
JOURNAL ARTICLE
Etienne Bastien, Sophie Lefèvre-Arbogast, Justine Lequesne, François Gernier, François Cherifi, Olivier Rigal, Lydia Guittet, Jean-Michel Grellard, Giulia Binarelli, Marie Lange, Marie Fernette, Laure Tron, Adeline Morel, Doriane Richard, Bénédicte Griffon, Alexandra Leconte, Florian Quilan, Louis-Ferdinand Pépin, Fabrice Jardin, Marianne Leheurteur, Audrey Faveyrial, Bénédicte Clarisse, Florence Joly
BACKGROUND: Patients with cancer may be particularly vulnerable to psychological consequences of the COVID-19 pandemic. We studied the prevalence and evolution of posttraumatic stress symptoms (PTSS) in patients with cancer during the pandemic waves, and we investigated factors associated with high symptoms. METHODS: COVIPACT is a 1-year longitudinal prospective study of French patients with solid/hematologic malignancies receiving treatment during the first nationwide lockdown...
February 22, 2023: Journal of the National Comprehensive Cancer Network: JNCCN
#8
Vincent Cottin, Philippe Bonniaud, Jacques Cadranel, Bruno Crestani, Stéphane Jouneau, Sylvain Marchand-Adam, Hilario Nunes, Lidwine Wémeau-Stervinou, Emmanuel Bergot, Elodie Blanchard, Raphaël Borie, Arnaud Bourdin, Cécile Chenivesse, Annick Clément, Emmanuel Gomez, Anne Gondouin, Sandrine Hirschi, François Lebargy, Charles-Hugo Marquette, David Montani, Grégoire Prévot, Sébastien Quetant, Martine Reynaud-Gaubert, Mathieu Salaun, Olivier Sanchez, Bruno Trumbic, Karim Berkani, Pierre-Yves Brillet, Marion Campana, Lara Chalabreysse, Gérard Chatté, Didier Debieuvre, Gilbert Ferretti, Jean-Michel Fourrier, Nicolas Just, Marianne Kambouchner, Bertrand Legrand, Frédéric Le Guillou, Jean-Pierre Lhuillier, Anas Mehdaoui, Jean-Marc Naccache, Catherine Paganon, Martine Rémy-Jardin, Salim Si-Mohamed, Philippe Terrioux
BACKGROUND: Since the latest 2017 French guidelines, knowledge about idiopathic pulmonary fibrosis has evolved considerably. METHODS: Practical guidelines were drafted on the initiative of the Coordinating Reference Center for Rare Pulmonary Diseases, led by the French Language Pulmonology Society (SPLF), by a coordinating group, a writing group, and a review group, with the involvement of the entire OrphaLung network, pulmonologists practicing in various settings, radiologists, pathologists, a general practitioner, a health manager, and a patient association...
August 4, 2022: Respiratory medicine and research
#9
JOURNAL ARTICLE
Hannah E Christie, Courtney R Chang, Isabelle R Jardine, Monique E Francois
The purpose of this study was to determine whether postmeal walking (breaking up exercise into short bouts after meals) is an effective and feasible alternate to continuous walking for the management of gestational diabetes. Forty-one women with gestational diabetes were randomised between wk 28-30 gestation to either standard-care (30-min continuous exercise) or standard-care with postmeal walking (10-min of walking after breakfast, lunch and dinner). Continuous glucose and activity monitors were worn to measure glycaemic control and adherence during three-days of standard-care (baseline) followed by three-days of postmeal or continuous walking...
August 19, 2022: Applied Physiology Nutrition and Metabolism
#10
EDITORIAL
Can Peer Review Be Kinder? Supportive Peer Review: A Re-Commitment to Kindness and a Call to Action.
Catherine M Clase, Elizabeth Dicks, Rachel Holden, Manish M Sood, Adeera Levin, Kamyar Kalantar-Zadeh, Linda W Moore, Susan J Bartlett, Aminu K Bello, Clara Bohm, Darren Bridgewater, Josee Bouchard, Dylan Burger, Juan Jesús Carrero, Maoliosa Donald, Meghan Elliott, Maya J Goldenberg, Meg Jardine, Ngan N Lam, W Joy Maddigan, François Madore, Thomas A Mavrakanas, Amber O Molnar, G V Ramesh Prasad, Claudio Rigatto, Karthik K Tennankore, Elena Torban, Laurel Trainor, Christine A White, Sunny Hartwig
Peer review aims to select articles for publication and to improve articles before publication. We believe that this process can be infused by kindness without losing rigor. In 2014, the founding editorial team of the Canadian Journal of Kidney Health and Disease (CJKHD) made an explicit commitment to treat authors as we would wish to be treated ourselves. This broader group of authors reaffirms this principle, for which we suggest the terminology "supportive review."
2022: Canadian Journal of Kidney Health and Disease
#11
Karim Tazarourte, François-Xavier Ageron, Aurélie Avondo, Edward Barnard, Xavier Bobbia, Eric Cesareo, Charlotte Chollet-Xemard, Sonja Curac, Thibaut Desmettre, Carlos E L Khoury, Tobias Gauss, Cédric Gil-Jardine, Tim Harris, Matthieu Heidet, Frédéric Lapostolle, Catherine Pradeau, Aurélien Renard, David Sapir, Jean-Pierre Tourtier, Stéphane Travers
No abstract text is available yet for this article.
June 2022: Anaesthesia, Critical Care & Pain Medicine
#12
JOURNAL ARTICLE
Marie-Delphine Lanic, François Le Loarer, Vinciane Rainville, Vincent Sater, Mathieu Viennot, Ludivine Beaussire, Pierre-Julien Viailly, Emilie Angot, Isabelle Hostein, Fabrice Jardin, Philippe Ruminy, Marick Laé
Morphological, immunohistochemical, and molecular methods often need to be combined for accurate diagnosis and optimal clinical management of sarcomas. Here, we have developed, a new molecular diagnostic assay, for the detection of gene fusions in sarcomas. This targeted multiplexed next-generation sequencing (NGS)-based method utilizes ligation dependent reverse-transcriptase polymerase chain reaction (LD-RT-PCR-NGS) to detect oncogenic fusion transcripts involving 137 genes, leading to 139 gene fusions known to be recurrently rearranged in soft-tissue and bone tumors...
January 24, 2022: Modern Pathology
#13
JOURNAL ARTICLE
Florence Joly, Olivier Rigal, Lydia Guittet, Sophie Lefèvre-Arbogast, Jean-Michel Grellard, Giulia Binarelli, Marie Lange, Chantal Rieux, Marie Fernette, Laure Tron, François Gernier, Romain Travers, Adeline Morel, Doriane Richard, Bénédicte Griffon, Alexandra Leconte, Etienne Bastien, Florian Quilan, Louis-Ferdinand Pépin, Fabrice Jardin, Marianne Leheurteur, Bénédicte Clarisse, Justine Lequesne, Audrey Faveyrial
BACKGROUND: The COVID-19 pandemic may induce post-traumatic stress disorder (PTSD) symptoms among patients with cancer, who also face adaptations to their treatment. The authors assessed the occurrence of PTSD symptoms, investigated pandemic-induced adjustments in medical oncology practice in patients with cancer, and explored risk factors for PTSD and the association between PTSD symptoms, insomnia, and quality of life (QoL). METHODS: This prospective French study was conducted in patients with solid/hematologic tumors who were receiving medical treatment in the day care departments of 2 cancer centers during the lockdown...
December 15, 2021: Cancer
#14
JOURNAL ARTICLE
Fanny Drieux, Philippe Ruminy, Vincent Sater, Vinciane Marchand, Virginie Fataccioli, Marie-Delphine Lanic, Mathieu Viennot, Pierre-Julien Viailly, Nouhoum Sako, Cyrielle Robe, Aurélie Dupuy, David Vallois, Liana Veresezan, Elsa Poullot, Jean-Michel Picquenot, Céline Bossard, Marie Parrens, François Lemonnier, Fabrice Jardin, Laurence de Leval, Philippe Gaulard
The genetic basis of peripheral T-cell lymphoma (PTCL) is complex and encompasses several recurrent fusion transcripts discovered over the past years by means of massive parallel sequencing. However, there is currently no affordable and rapid technology for their simultaneous detection in clinical samples. Herein, we developed a multiplex ligation-dependent RT-PCR-based assay, followed by high-throughput sequencing, to detect 33 known PTCL-associated fusion transcripts. ALK fusion transcripts were detected in 15 of 16 ALK-positive anaplastic large-cell lymphomas...
June 18, 2021: Journal of Molecular Diagnostics: JMD
#15
MULTICENTER STUDY
Marie Csanyi-Bastien, Marie-Delphine Lanic, Ludivine Beaussire, Sandra Ferric, Arnaud François, Didier Meseure, Fabrice Jardin, Michel Wassef, Philippe Ruminy, Marick Laé
Secretory carcinoma (SC) is characterized by ETV6 rearrangements, most often ETV6-NTRK3 fusion. Given its histologic overlap with other salivary gland tumors (SGTs), SCs can be difficult to diagnose without genetic confirmation. A recently developed pan-TRK (tropomyosin receptor kinase) antibody shows promise for identifying tumors with NTRK (neurotrophic tyrosine kinase receptor 3) fusions. The aim of this study was to evaluate the utility of pan-TRK immunohistochemistry in distinguishing SCs from mimics and selecting patients eligible for TRK inhibitor clinical trials...
November 1, 2021: American Journal of Surgical Pathology
#16
JOURNAL ARTICLE
Clarisse Cazelles, Karim Belhadj, Hélène Vellemans, Vincent Camus, Elsa Poullot, Philippe Gaulard, Liana Veresezan, Emmanuel Itti, Stéphanie Becker, Muriel Carvalho, Jehan Dupuis, Fabien Le Bras, François Lemonnier, Louise Roulin, Taoufik El Gnaoui, Fabrice Jardin, Nicolas Mounier, Hervé Tilly, Corinne Haioun
There is no established standard treatment for relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) in patients who are not eligible to receive an intensive treatment. The combination of rituximab gemcitabine and oxaliplatin (R-GemOx) is widely used in this population but data are scarce. We retrospectively collected the data of 196 patients with R/R DLBCL treated with R-GemOx in two French centers over a period of 15 years. The median age of the population was 72 years (range, 24-89), 63% of the patients had an international prognostic index of 3 or higher and 57% were refractory to the last treatment...
September 2021: Leukemia & Lymphoma
#17
JOURNAL ARTICLE
Hadjer Miloudi, Élodie Bohers, François Guillonneau, Antoine Taly, Vincent Cabaud Gibouin, Pierre-Julien Viailly, Gaëtan Jego, Luca Grumolato, Fabrice Jardin, Brigitte Sola
The XPO1 gene encodes exportin 1 (XPO1) that controls the nuclear export of cargo proteins and RNAs. Almost 25% of primary mediastinal B-cell lymphoma (PMBL) and classical Hodgkin lymphoma (cHL) cases harboured a recurrent XPO1 point mutation (NM_003400, chr2:g61718472C>T) resulting in the E571K substitution within the hydrophobic groove of the protein, the site of cargo binding. We investigated the impact of the XPO1 E571K mutation using PMBL/cHL cells having various XPO1 statuses and CRISPR-Cas9-edited cells in which the E571K mutation was either introduced or knocked-out...
September 30, 2020: Cancers
#18
JOURNAL ARTICLE
Margarita Gutiérrez-Ruiz, Jean-François Parrot, Carolina Ramírez-Núñez, Leticia Pérez-Manzanera, Daniel Amaro-Ramírez, Lizbeth Jardines-Mendoza
A three-dimensional interpolation method based on a digital elevation model (DEM) was developed to assess the impact of mining and metallurgical activity on the Claro River (Hidalgo, Mexico). This method was used to analyze the spatial concentration of manganese in sediments, water, and fish (viscera and muscle). Input data correspond to chemical manganese (Mn) analysis of the aforementioned environmental matrices, mining discharge volumes, and rainfall data. The three-dimensional model made it possible to (a) define Mn dispersion (19 km for sediments and 13 km for viscera); (b) identify northern meanders of the Claro River as areas of Mn accumulation in sediments and fish; and (c) determine river features that influence Mn concentration in fish...
September 12, 2020: Environmental Science and Pollution Research International
#19
JOURNAL ARTICLE
(no author information available yet)
BACKGROUND: Risk factors for coronavirus disease 2019 (COVID-19) death in sub-Saharan Africa and the effects of human immunodeficiency virus (HIV) and tuberculosis on COVID-19 outcomes are unknown. METHODS: We conducted a population cohort study using linked data from adults attending public-sector health facilities in the Western Cape, South Africa. We used Cox proportional hazards models, adjusted for age, sex, location, and comorbidities, to examine the associations between HIV, tuberculosis, and COVID-19 death from 1 March to 9 June 2020 among (1) public-sector "active patients" (≥1 visit in the 3 years before March 2020); (2) laboratory-diagnosed COVID-19 cases; and (3) hospitalized COVID-19 cases...
October 5, 2021: Clinical Infectious Diseases
#20
JOURNAL ARTICLE
Natayme Rocha Tartaglia, Aurélie Nicolas, Vinícius de Rezende Rodovalho, Brenda Silva Rosa da Luz, Valérie Briard-Bion, Zuzana Krupova, Anne Thierry, François Coste, Agnes Burel, Patrice Martin, Julien Jardin, Vasco Azevedo, Yves Le Loir, Eric Guédon
Staphylococcus aureus is an important opportunistic pathogen of humans and animals. It produces extracellular vesicles (EVs) that are involved in cellular communication and enable inter-kingdom crosstalk, the delivery of virulence factors and modulation of the host immune response. The protein content of EVs determines their biological functions. Clarifying which proteins are selected, and how, is of crucial value to understanding the role of EVs in pathogenesis and the development of molecular delivery systems...
May 21, 2020: Scientific Reports
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