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https://www.readbyqxmd.com/read/28738186/neonatal-screening-9-of-children-with-filter-paper-thyroid-stimulating-hormone-levels-between-5-and-10%C3%AE-iu-ml-have-congenital-hypothyroidism
#1
Flávia C Christensen-Adad, Carolina T Mendes-Dos-Santos, Maura M F Goto, Letícia E Sewaybricker, Lília F R D'Souza-Li, Gil Guerra-Junior, André M Morcillo, Sofia Helena V Lemos-Marini
OBJECTIVES: To determine the prevalence of congenital hypothyroidism in children with filter paper thyroid-stimulating hormone levels between 5 and 10μUI/mL in the neonatal screening. METHODS: This was a retrospective study including children screened from 2003 to 2010, with filter paper thyroid-stimulating hormone levels between 5 and 10μIU/mL, who were followed-up during the first two years of life when there was no serum thyroid-stimulating hormone normalization...
July 21, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28733468/management-impact-effects-on-quality-of-life-and-prognosis-in-men1
#2
Francesca Marini, Francesca Giusti, Francesco Tonelli, Maria Luisa Brandi
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant endocrine tumor syndrome, caused by inactivating mutations of the MEN1 tumor suppressor gene at 11q13 locus, which predisposes to develop tumors in target neuroendocrine tissues. Since the positional cloning and identification of the causative gene in 1997, genetic diagnosis, by the sequencing-based research of gene mutations, has become an important tool in the early and differential diagnosis of the disease. Application of the genetic test, in MEN1 index cases and in first degree relatives of mutated patients, has been constantly increasing during the last two decades, also thanks to the establishment of multidisciplinary referral centers and specific genetic counselling, and thanks to the wide availability of high throughput instruments for gene sequencing and gene mutation identification...
July 21, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28730561/men-experience-higher-risk-of-pneumonia-and-death-after-intracerebral-hemorrhage
#3
Sandro Marini, Andrea Morotti, Umme K Lena, Joshua N Goldstein, Steven M Greenberg, Jonathan Rosand, Christopher D Anderson
BACKGROUND: Infectious complications worsen outcome after intracerebral hemorrhage (ICH). We investigated the impact of sex on post-ICH infections and mortality. METHODS: Consecutive ICH patients (admitted to a single hospital between 1994 and 2015) were retrospectively assessed via chart review to ascertain the following in-hospital infections: urinary tract infection (UTI), pneumonia, and sepsis. Adjusted logistic regression was performed to identify associations between sex, infection, and mortality at 90 days...
July 20, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28718698/pegging-down-risk-factors-for-peg-asparaginase-hepatotoxicity-in-patients-with-acute-lymphoblastic-leukemia-%C3%A2
#4
Caitlin R Rausch, Bernard L Marini, Lydia L Benitez, Allison Elias, Patrick W Burke, Dale Bixby, Anthony J Perissinotti
Asparaginase is commonly de-emphasized/omitted in adult acute lymphoblastic leukemia regimens due to poor tolerability, including hepatotoxicity (HTX). Adult patients (n = 100) given induction therapy containing pegylated asparaginase (PEG) from January 2008 to February 2016 were evaluated for HTX. Sixteen patients met criteria for HTX (direct bilirubin >3 g/dL). A multivariable model identified body surface area >2m(2) (OR 7.40; 95% CI: 1.73-31.61, p = .007), albumin <3 mg/dL (OR 4.62; 95% CI: 1...
July 18, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28716219/sex-differences-in-intracerebral-hemorrhage-expansion-and-mortality
#5
Sandro Marini, Andrea Morotti, Alison M Ayres, Katherine Crawford, Christina E Kourkoulis, Umme K Lena, Edip M Gurol, Anand Viswanathan, Joshua N Goldstein, Steven M Greenberg, Alessandro Biffi, Jonathan Rosand, Christopher D Anderson
BACKGROUND AND OBJECTIVE: Due to conflicting results in multiple studies, uncertainty remains regarding sex differences in severity and mortality after intracerebral hemorrhage (ICH). We investigated the impact of sex on ICH severity, expansion, and mortality. METHODS: We analyzed prospectively collected ICH patients and assessed clinical variables and mortality rate. Mediation analyses were used to examine associations between sex and mortality and sex and hematoma expansion...
August 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28714595/telocytes-in-normal-and-keratoconic-human-cornea-an-immunohistochemical-and-transmission-electron-microscopy-study
#6
Mirca Marini, Rita Mencucci, Irene Rosa, Eleonora Favuzza, Daniele Guasti, Lidia Ibba-Manneschi, Mirko Manetti
Telocytes (TC) are typically defined as cells with telopodes by their ultrastructural features. Their presence was reported in the interstitium of various organs in vertebrates, including humans. However, no study has yet described the presence of TC in the human eye and in particular, within the stromal compartment of the cornea. To address this issue, samples of normal and pathologic (keratoconic) human corneas were tested by immunohistochemistry for CD34, platelet-derived growth factor receptor α (PDGFRα) and c-kit/CD117 or examined by transmission electron microscopy...
July 17, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28714150/development-and-psychometric-testing-of-a-new-instrument-to-measure-the-caring-behaviour-of-nurses-in-italian-acute-care-settings
#7
Michela Piredda, Valerio Ghezzi, Elisa Fenizia, Anna Marchetti, Tommasangelo Petitti, Maria Grazia De Marinis, Alessandro Sili
AIM: To develop and psychometrically test the Italian-language Nurse Caring Behaviours Scale, a short measure of nurse caring behaviour as perceived by inpatients. BACKGROUND: Patient perceptions of nurses' caring behaviours are a predictor of care quality. Caring behaviours are culture-specific, but no measure of patient perceptions has previously been developed in Italy. Moreover, existing tools show unclear psychometric properties, are burdensome for respondents, or are not widely applicable...
July 16, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28713682/predictive-biomarkers-of-immunotherapy-for-non-small-cell-lung-cancer-results-from-an-experts-panel-meeting-of-the-italian-association-of-thoracic-oncology
#8
REVIEW
Cesare Gridelli, Andrea Ardizzoni, Massimo Barberis, Federico Cappuzzo, Francesca Casaluce, Romano Danesi, Giancarlo Troncone, Filippo De Marinis
Unleashing the potential of immune system to fight cancer has become one of the main promising treatment modalities for advanced non-small cell lung cancer (NSCLC). The knowledge of numerous factors that come into play in the cancer-immunity cycle provide a wide range of potential therapeutic targets, including monoclonal antibodies that inhibits the programmed death-1 (PD-1) checkpoint pathway. Over the last two years, nivolumab, pembrolizumab and atezolizumab received approval for treatment of pretreated advanced NSCLC, and more recently, immunotherapy with pembrolizumab is the new standard of care as first-line in patients with high levels of programmed death-ligand 1 (PD-L1) expression...
June 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/28711034/pressure-in-an-exactly-solvable-model-of-active-fluid
#9
Umberto Marini Bettolo Marconi, Claudio Maggi, Matteo Paoluzzi
We consider the pressure in the steady-state regime of three stochastic models characterized by self-propulsion and persistent motion and widely employed to describe the behavior of active particles, namely, the Active Brownian particle (ABP) model, the Gaussian colored noise (GCN) model, and the unified colored noise approximation (UCNA) model. Whereas in the limit of short but finite persistence time, the pressure in the UCNA model can be obtained by different methods which have an analog in equilibrium systems, in the remaining two models only the virial route is, in general, possible...
July 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28710115/acromegaly-is-associated-with-increased-cancer-risk-a-survey-in-italy
#10
Massimo Terzolo, Giuseppe Reimondo, Paola Berchialla, Emanuele Ferrante, Elena Malchiodi, Laura De Marinis, Rosario Pivonello, Silvia Grottoli, Marco Losa, Salvatore Cannavò, Diego Ferone, Marcella Montini, Marta Bondanelli, Ernesto de Menis, Chiara Martini, Efisio Puxeddu, Antonino Velardo, Alessandro Peri, Marco Faustini-Fustini, Patrizia Tita, Francesca Pigliaru, Giulia Peraga, Giorgio Borretta, Carla Scaroni, Nicoletta Bazzoni, Antonio Bianchi, Alessandro Berton, Andreea Liliana Serban, Roberto Baldelli, Letizia Fatti, Annamaria Al Colao, Maura Arosio
It is debated if acromegalic patients have an increased risk to develop malignancies. The aim of the present study was to assess the standardized incidence ratios (SIRs) of different types of cancer in acromegaly on a large series of acromegalic patients managed in the somatostatin analogs era. It was evaluated the incidence of cancer in an Italian nationwide multicenter cohort study of 1512 acromegalic patients, 624 men and 888 women, mean age at diagnosis 45 +/- 13 years, followed-up for a mean of 10 years (12573 person-years) in respect to the general Italian population...
July 14, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28708686/clinical-deployment-of-the-esophageal-balloon-catheter-making-the-case
#11
John J Marini
No abstract text is available yet for this article.
August 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28705098/prevention-of-systemic-toxicity-in-hyperthermic-isolated-lung-perfusion-using-radioisotopic-leakage-monitoring
#12
Francesco Fiz, Giuseppe Villa, Enrico Ferrari, Elena Pomposelli, Silvia Morbelli, Antonella Alloisio, Daniela Pende, Raffaella Meazza, Cristina Gereloni, Cecilia Marini, Giovanni Battista Ratto, Gianmario Sambuceti
RATIONALE: Hyperthermic isolated lung Perfusion (ILuP) is used to deliver high-dose chemotherapy to pulmonary metastases while sparing systemic toxicity. Accurate leakage monitoring is however necessary. This study aimed to verify the accuracy of radionuclide leakage monitoring in patients undergoing ILuP, by comparing this method with serial blood sampling. METHODS: A total of 15 consecutive ILuP procedures were performed on eleven patients affected by lung metastases from soft tissue sarcoma...
July 13, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28701178/the-future-of-mechanical-ventilation-lessons-from-the-present-and-the-past
#13
REVIEW
Luciano Gattinoni, John J Marini, Francesca Collino, Giorgia Maiolo, Francesca Rapetti, Tommaso Tonetti, Francesco Vasques, Michael Quintel
The adverse effects of mechanical ventilation in acute respiratory distress syndrome (ARDS) arise from two main causes: unphysiological increases of transpulmonary pressure and unphysiological increases/decreases of pleural pressure during positive or negative pressure ventilation. The transpulmonary pressure-related side effects primarily account for ventilator-induced lung injury (VILI) while the pleural pressure-related side effects primarily account for hemodynamic alterations. The changes of transpulmonary pressure and pleural pressure resulting from a given applied driving pressure depend on the relative elastances of the lung and chest wall...
July 12, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28699219/enzyme-prodrug-therapy-engineered-into-electrospun-fibers-with-embedded-liposomes-for-controlled-localized-synthesis-of-therapeutics
#14
Rona Chandrawati, Morten T J Olesen, Thatiane C C Marini, Gurpal Bisra, Anne Géraldine Guex, Marcelo G de Oliveira, Alexander N Zelikin, Molly M Stevens
Enzyme prodrug therapy (EPT) enables localized conversion of inert prodrugs to active drugs by enzymes. Performance of EPT necessitates that the enzyme remains active throughout the time frame of the envisioned therapeutic application. β-glucuronidase is an enzyme with historically validated performance in EPT, however it retains its activity in biomaterials for an insufficiently long period of time, typically not exceeding 7 d. Herein, the encapsulation of β-glucuronidase in liposomal subcompartments within poly(vinyl alcohol) electrospun fibers is reported, leading to the assembly of biocatalytically active materials with activity of the enzyme sustained over at least seven weeks...
July 12, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28697948/catalyzing-improvements-in-all-therapy-with-asparaginase
#15
REVIEW
Bernard L Marini, Anthony J Perissinotti, Dale L Bixby, Julia Brown, Patrick W Burke
Asparaginase remains a cornerstone of ALL therapy and is one of the key contributing factors to improved outcomes in adolescent and young adult (AYA) patients treated on pediatric protocols. Asparagine depletion has been associated with improved outcomes in ALL patients; this has led to an increased emphasis on optimizing asparagine depletion in ALL patients of all ages. To ensure adequate asparagine depletion, the use of therapeutic drug monitoring of asparaginase therapy holds much promise, yet remains underutilized in practice...
July 5, 2017: Blood Reviews
https://www.readbyqxmd.com/read/28696707/cyclophilin-b-deficiency-causes-abnormal-dentin-collagen-matrix
#16
Masahiko Terajima, Yuki Taga, Wayne A Cabral, Masako Nagasawa, Noriko Sumida, Shunji Hattori, Joan C Marini, Mitsuo Yamauchi
Cyclophilin B (CypB) is an endoplasmic reticulum-resident protein that regulates collagen folding, and also contributes to prolyl 3-hydroxylation (P3H) and lysine (Lys) hydroxylation of collagen. In this study, we characterized dentin type I collagen in CypB null (KO) mice, a model of recessive osteogenesis imperfecta type IX, and compared to those of wild-type (WT) and heterozygous (Het) mice. Mass spectrometric analysis demonstrated that the extent of P3H in KO collagen was significantly diminished compared to WT/Het...
July 11, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28692278/ab-initio-calculations-of-ultra-short-carrier-dynamics-in-2d-materials-valley-depolarization-in-single-layer-wse2
#17
Alejandro Molina-Sánchez, Davide Sangalli, Ludger Wirtz, Andrea Marini
In single-layer WSe2, a paradigmatic semiconducting transition metal dichalcogenide, a circularly polarized laser field can selectively excite electronic transitions in one of the inequivalent K(±) valleys. Such a selective valley population corresponds to a pseudospin that can be used as a degree of freedom in valleytronics provided that the time scale for valley depolarization is sufficiently large. Yet, the mechanism behind the valley depolarization still remains heavily debated. Recent time-dependent Kerr experiments have provided an accurate way to visualize the valley dynamics by measuring the rotation of a linearly polarized probe pulse applied after a circularly polarized pump pulse...
July 10, 2017: Nano Letters
https://www.readbyqxmd.com/read/28689007/creativity-and-psychiatric-illness-a-functional-perspective-beyond-chaos
#18
REVIEW
Federica Vellante, Fabiola Sarchione, Sjoerd J H Ebisch, Anatolia Salone, Laura Orsolini, Stefano Marini, Alessandro Valchera, Michele Fornaro, Alessandro Carano, Felice Iasevoli, Giovanni Martinotti, Massimo Di Giannantonio, Domenico De Berardis
No abstract text is available yet for this article.
July 5, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28687016/safety-and-tolerability-of-deferasirox-in-pediatric-hematopoietic-stem-cell-transplant-recipients-one-facility-s-five-years-experience-of-chelation-treatment
#19
Natalia Maximova, Massimo Gregori, Roberto Simeone, Aurelio Sonzogni, Giulia Boz, Carmen Fucile, Valeria Marini, Antonietta Martelli, Francesca Mattioli
42 pediatric patients with iron overload, who underwent liver biopsy and DFX treatment after hematopoietic stem cell transplantation were included in the study group. The patients were divided into two groups diversified according to deferasirox trough plasma concentrations (DFX Ctrough) with cut-off equal to10 mcg/mL. The average dose of DFX was 25.9 mg/kg in the DFX Ctrough < 10 mcg/mL group versus 19.2 mg/kg in the DFX Ctrough > 10 mcg/mL group (p=0,0003). The mean duration of DFX treatment was 135...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28685184/morphological-and-molecular-characterisation-of-aporocotyle-margolisi-smith-1967-digenea-aporocotylidae-from-the-north-pacific-hake-merluccius-productus-ayres-gadiformes-merlucciidae-off-oregon-usa
#20
Jesus S Hernández-Orts, David I Hernández-Mena, Gema Alama-Bermejo, Roman Kuchta, Kym C Jacobson
Aporocotylid blood flukes conspecific with Aporocotyle margolisi Smith, 1967 were collected from the bulbus arteriosus of the North Pacific hake Merluccius productus (Ayres). This study revisits the morphology of A. margolisi, including drawings, measurements and scanning electron microscopy images, and provides for the first time molecular data for the large subunit of the ribosomal RNA (28S rDNA) and the mitochondrial cytochrome c oxidase subunit 1 (cox1) genes for this species. A 28S rDNA phylogenetic study of A...
July 6, 2017: Systematic Parasitology
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