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https://www.readbyqxmd.com/read/28328131/recessive-mutations-in-slc35a3-cause-early-onset-epileptic-encephalopathy-with-skeletal-defects
#1
Carla Marini, Katia Hardies, Tiziana Pisano, Patrick May, Sarah Weckhuysen, Elena Cellini, Arvid Suls, Davide Mei, Rudi Balling, Peter D Jonghe, Ingo Helbig, Domenico Garozzo, Renzo Guerrini
We describe the clinical and whole genome sequencing (WGS) study of a non-consanguineous Italian family in which two siblings, a boy and a girl, manifesting a severe epileptic encephalopathy (EE) with skeletal abnormalities, carried novel SLC35A3 compound heterozygous mutations. Both siblings exhibited infantile spasms, associated with focal, and tonic vibratory seizures from early infancy. EEG recordings showed a suppression-burst (SB) pattern and multifocal paroxysmal activity in both. In addition both had quadriplegia, acquired microcephaly, and severe intellectual disability...
April 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28327526/survivin-and-naip-in-human-benign-prostatic-hyperplasia-protective-role-of-the-association-of-serenoa-repens-lycopene-and-selenium-from-the-randomized-clinical-study
#2
Giuseppe Morgia, Antonio Micali, Mariagrazia Rinaldi, Natasha Irrera, Herbert Marini, Domenico Puzzolo, Antonina Pisani, Salvatore Privitera, Giorgio I Russo, Sebastiano Cimino, Antonio Ieni, Vincenzo Trichilo, Domenica Altavilla, Francesco Squadrito, Letteria Minutoli
Benign prostatic hyperplasia (BPH) treatment includes the apoptosis machinery modulation through the direct inhibition of caspase cascade. We previously demonstrated that Serenoa repens (Ser) with lycopene (Ly) and selenium (Se) reawakened apoptosis by reducing survivin and neuronal apoptosis inhibitory protein (NAIP) levels in rats. The aim of this study was to evaluate the effectiveness of Ser-Se-Ly association on survivin and NAIP expression in BPH patients. Ninety patients with lower urinary tract symptoms (LUTS) due to clinical BPH were included in this randomized, double-blind, placebo-controlled trial...
March 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28323974/phenotypic-spectrum-in-osteogenesis-imperfecta-due-to-mutations-in-tmem38b-unravelling-a-complex-cellular-defect
#3
Emma A Webb, Meena Balasubramanian, Nadja Fratzl-Zelman, Wayne A Cabral, Hannah Titheradge, Atif Alsaedi, Vrinda Saraff, Julie Vogt, Trevor Cole, Susan Stewart, Nicola J Crabtree, Brandi M Sargent, Sonja Gamsjaeger, Eleftherios P Paschalis, Paul Roschger, Klaus Klaushofer, Nick J Shaw, Joan C Marini, Wolfgang Högler
Context: Recessive mutations in TMEM38B cause type XIV osteogenesis imperfecta (OI) by dysregulating intracellular calcium flux. Objectives: Clinical and bone material phenotype description and osteoblast differentiation studies. Design and Setting: Natural history study in paediatric research centres. Patients: Eight patients with type XIV OI. Main Outcome Measures: Clinical examinations included: bone mineral density, radiographs, echocardiography and muscle biopsy...
March 16, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28318657/radiation-dose-among-different-cardiac-and-vascular-invasive-procedures-the-rodeo-study
#4
Alessandro Sciahbasi, Giuseppe Ferrante, Dionigi Fischetti, Daniel Jonathan Miklin, Alessandro Sarandrea, Valentina Schirripa, Fabrizio Guarracini, Arash Arya, Giorgio Loreni, Antonio Bruni, Stefano Rigattieri, Massimiliano Marini, Simone Vagnarelli, Germano Scevola, Bernhard Reimers, Gerhard Hindricks, Mauricio Cohen
BACKGROUND: Interventional radiology and cardiology procedures contribute significantly to the collective dose of radiation exposure from medical interventions. Recent and dedicated studies comparing directly these procedures in term of patient radiation exposure are lacking. Our aim was to compare radiation exposure among different interventional procedures performed under fluoroscopic guidance. METHODS: The RODEO study (NCT: 02972736) is an international observational retrospective multicenter study enrolling all patients undergoing diagnostic or interventional procedures performed by different interventional operators (i...
March 10, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28316302/high-frequency-oscillatory-ventilation-hfov-as-primary-ventilator-strategy-in-the-management-of-severe-acute-respiratory-distress-syndrome-ards-with-pneumothorax-in-the-setting-of-trauma
#5
Kartik Prabhakaran, Daniel Hagler, Dominick Vitale, Alejandro Betancourt, Patrizio Petrone, Corrado P Marini
No abstract text is available yet for this article.
March 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28303961/the-metabolic-waste-ammonium-regulates-mtorc2-and-mtorc1-signaling
#6
Ahmad Merhi, Paul Delrée, Anna Maria Marini
Two structurally and functionally distinct mammalian TOR complexes control cell growth and metabolism in physiological and pathological contexts including cancer. Upregulated glutaminolysis is part of the metabolic reprogramming occurring in cancer, providing fuels for growth but also liberating ammonium, a potent neurotoxic waste product. Here, we identify ammonium as a novel dose-dependent signal mediating rapid mTORC2 activation and further regulating mTORC1. We show that ammonium induces rapid RICTOR-dependent phosphorylation of AKT-S473, a process requiring the PI3K pathway and further involving the Src-family kinase YES1, the FAK kinase and the ITGβ1 integrin...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28303554/imaging-of-the-oesophagus-beyond-cancer
#7
REVIEW
Thomas Marini, Amit Desai, Katherine Kaproth-Joslin, John Wandtke, Susan K Hobbs
Non-malignant oesophageal diseases are critical to recognize, but can be easily overlooked or misdiagnosed radiologically. In this paper, we cover the salient clinical features and imaging findings of non-malignant pathology of the oesophagus. We organize the many non-malignant diseases of the oesophagus into two major categories: luminal disorders and wall disorders. Luminal disorders include dilatation/narrowing (e.g. achalasia, scleroderma, and stricture) and foreign body impaction. Wall disorders include wall thickening (e...
March 17, 2017: Insights Into Imaging
https://www.readbyqxmd.com/read/28298288/-18-f-fluorodeoxyglucose-imaging-of-inflammation-ready-to-represent-a-standard-in-diagnosing-endocarditis
#8
EDITORIAL
Gianmario Sambuceti, Silvia Morbelli, Anna Maria Orengo, Matteo Bauckneht, Cecilia Marini
No abstract text is available yet for this article.
March 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28289805/comparison-of-lindane-and-carbaryl-pesticide-bioaccumulation-in-the-common-sole-solea-solea
#9
Frapiccini Emanuela, Scarcella Giuseppe, Guicciardi Stefano, Betti Mattia, Marini Mauro
Organochlorines and carbamates are common pesticides predominantly employed in agriculture. Large amounts of pesticides make their way into rivers and marine habitats. They accumulate in aquatic organisms through different exposure routes and gradually move up the food chain. Since contaminant bioaccumulation in animals is affected by several factors, this work harnessed several different approaches to explore the persistence of lindane, a long banned organochlorine pesticide, and carbaryl, a newer generation pesticide, in common sole (Solea solea), a major commercial species in Adriatic fisheries...
March 13, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28287209/-primary-cardiac-lymphoma-in-an-immunocompetent-young-adult-outcome-with-chemotherapy
#10
Gian Piero Perna, Guido Gini, Michela Brambatti, Ilaria Battistoni, Marco Marini, Luca Angelini, Matteo Francioni, Gaia Goteri, Melissa Dottori
Primitive cardiac lymphoma (PCL) is a rare disease accounting for only 1-2% of primary cardiac tumors. Diffuse large B cell lymphoma is the most common type and shows a rapid progression with poor prognosis. The clinical presentation of PCL is nonspecific, and echocardiographic study is essential to the initial work-up. Magnetic resonance imaging and computed tomography scan are the methods of choice for the assessment of tumor extension. The definitive diagnosis is histopathology examination. Chemotherapy and radiotherapy represent the best treatment and should be started promptly after PCL diagnosis...
January 2017: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/28286545/erratum-to-iroa-international-register-of-open-abdomen-preliminary-results
#11
Federico Coccolini, Giulia Montori, Marco Ceresoli, Fausto Catena, Rao Ivatury, Michael Sugrue, Massimo Sartelli, Paola Fugazzola, Davide Corbella, Francesco Salvetti, Ionut Negoi, Monica Zese, Savino Occhionorelli, Stefano Maccatrozzo, Sergei Shlyapnikov, Christian Galatioto, Massimo Chiarugi, Zaza Demetrashvili, Daniele Dondossola, Yovcho Yovtchev, Orestis Ioannidis, Giuseppe Novelli, Mirco Nacoti, Desmond Khor, Kenji Inaba, Demetrios Demetriades, Torsten Kaussen, Asri Che Jusoh, Wagih Ghannam, Boris Sakakushev, Ohad Guetta, Agron Dogjani, Stefano Costa, Sandeep Singh, Dimitrios Damaskos, Arda Isik, Kuo-Ching Yuan, Francesco Trotta, Stefano Rausei, Aleix Martinez-Perez, Giovanni Bellanova, Vinicius Cordeiro Fonseca, Fernando Hernández, Athanasios Marinis, Wellington Fernandes, Martha Quiodettis, Miklosh Bala, Andras Vereczkei, Rafael L Curado, Gustavo Pereira Fraga, Bruno M Pereira, Mahir Gachabayov, Guillermo Perez Chagerben, Miguel Leon Arellano, Sefa Ozyazici, Gianluca Costa, Tugan Tezcaner, Luca Ansaloni
[This corrects the article DOI: 10.1186/s13017-017-0123-8.].
2017: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/28283821/significance-of-admission-hypoalbuminemia-in-acute-intracerebral-hemorrhage
#12
Andrea Morotti, Sandro Marini, Umme K Lena, Katherine Crawford, Kristin Schwab, Christina Kourkoulis, Alison M Ayres, M Edip Gurol, Anand Viswanathan, Steven M Greenberg, Christopher D Anderson, Jonathan Rosand, Joshua N Goldstein
Low levels of serum albumin may increase the risk of infections and mortality in critically ill patients. We tested the hypothesis that admission hypoalbuminemia predicted infectious complications and poor outcome in subjects with acute intracerebral hemorrhage (ICH). We analyzed a single center cohort of ICH patients collected between 1994 and 2015. Pneumonia, urinary tract infection and sepsis were retrospectively identified, according to validated criteria. Serum albumin was measured on admission and hypoalbuminemia was defined as total albumin ≤3...
March 10, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28275102/plasma-glutamine-is-a-minor-precursor-for-the-synthesis-of-citrulline-a-multispecies-study
#13
Juan C Marini, Umang Agarwal, Inka C Didelija, Mahshid Azamian, Barbara Stoll, Sandesh Cs Nagamani
Background: Glutamine is considered the main precursor for citrulline synthesis in many species, including humans. The transfer of (15)N from 2-[(15)N]-glutamine to citrulline has been used as evidence for this precursor-product relation. However, work in mice has shown that nitrogen and carbon tracers follow different moieties of glutamine and that glutamine contribution to the synthesis of citrulline is minor. It is unclear whether this small contribution of glutamine is also true in other species.Objective: The objective of the present work was to determine the contribution of glutamine to citrulline production by using nitrogen and carbon skeleton tracers in multiple species...
March 8, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28272374/what-is-new-in-the-mirna-world-regarding-osteosarcoma-and-chondrosarcoma
#14
REVIEW
Gaia Palmini, Francesca Marini, Maria Luisa Brandi
Despite the availability of multimodal and aggressive therapies, currently patients with skeletal sarcomas, including osteosarcoma and chondrosarcoma, often have a poor prognosis. In recent decades, advances in sequencing technology have revealed the presence of RNAs without coding potential known as non-coding RNAs (ncRNAs), which provides evidence that protein-coding genes account for only a small percentage of the entire genome. This has suggested the influence of ncRNAs during development, apoptosis and cell proliferation...
March 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28272095/transcranial-direct-current-stimulation-in-substance-use-disorders-a-systematic-review-of-scientific-literature
#15
Matteo Lupi, Giovanni Martinotti, Rita Santacroce, Eduardo Cinosi, Maria Carlucci, Stefano Marini, Tiziano Acciavatti, Massimo di Giannantonio
INTRODUCTION: New treatment options such as noninvasive brain stimulation have been recently explored in the field of substance use disorders (SUDs), including transcranial direct current stimulation (tDCS). OBJECTIVES: In light of this, we have performed a review of the scientific literature to assess efficacy and technical and methodological issues resulting from applying tDCS to the field of SUDs. METHODS: Our analysis highlighted the following selection criteria: clinical studies on tDCS and SUDs (alcohol, caffeine, cannabis, cocaine, heroin, methamphetamine, and nicotine)...
March 8, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28269302/robot-assisted-assessment-of-wrist-proprioception-does-wrist-proprioceptive-acuity-follow-weber-s-law
#16
Sara Contu, Francesca Marini, Leonardo Cappello, Lorenzo Masia
Proprioception is essential for planning and controlling limb posture and movement. In our recent work, we introduced a standardized robot-aided method for measuring proprioceptive discrimination thresholds at the wrist to obtain reliable and accurate measures of proprioceptive acuity. Weber's law defines discrimination thresholds as a constant ratio between the just noticeable difference and the reference or standard stimulus. Reporting Weber's fractions thus provides the possibility of comparing results with the reports of others collected worldwide...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28260978/measurements-of-the-formula-see-text-production-cross-section-in-lepton-jets-final-states-in-pp-collisions-at-8-formula-see-text-and-ratio-of-8-to-7%C3%A2-formula-see-text-cross-sections
#17
V Khachatryan, A M Sirunyan, A Tumasyan, W Adam, E Asilar, T Bergauer, J Brandstetter, E Brondolin, M Dragicevic, J Erö, M Flechl, M Friedl, R Frühwirth, V M Ghete, C Hartl, N Hörmann, J Hrubec, M Jeitler, V Knünz, A König, M Krammer, I Krätschmer, D Liko, T Matsushita, I Mikulec, D Rabady, B Rahbaran, H Rohringer, J Schieck, R Schöfbeck, J Strauss, W Treberer-Treberspurg, W Waltenberger, C-E Wulz, V Mossolov, N Shumeiko, J Suarez Gonzalez, S Alderweireldt, T Cornelis, E A De Wolf, X Janssen, A Knutsson, J Lauwers, S Luyckx, M Van De Klundert, H Van Haevermaet, P Van Mechelen, N Van Remortel, A Van Spilbeeck, S Abu Zeid, F Blekman, J D'Hondt, N Daci, I De Bruyn, K Deroover, N Heracleous, J Keaveney, S Lowette, M Maes, L Moreels, A Olbrechts, Q Python, D Strom, S Tavernier, W Van Doninck, P Van Mulders, G P Van Onsem, I Van Parijs, P Barria, H Brun, C Caillol, B Clerbaux, G De Lentdecker, G Fasanella, L Favart, A Grebenyuk, G Karapostoli, T Lenzi, A Léonard, T Maerschalk, A Marinov, L Perniè, A Randle-Conde, T Reis, T Seva, C Vander Velde, P Vanlaer, R Yonamine, F Zenoni, F Zhang, K Beernaert, L Benucci, A Cimmino, S Costantini, S Crucy, D Dobur, A Fagot, G Garcia, M Gul, J Mccartin, A A Ocampo Rios, D Poyraz, D Ryckbosch, S Salva, M Sigamani, N Strobbe, M Tytgat, W Van Driessche, E Yazgan, N Zaganidis, S Basegmez, C Beluffi, O Bondu, S Brochet, G Bruno, A Caudron, L Ceard, G G Da Silveira, C Delaere, D Favart, L Forthomme, A Giammanco, J Hollar, A Jafari, P Jez, M Komm, V Lemaitre, A Mertens, M Musich, C Nuttens, L Perrini, A Pin, K Piotrzkowski, A Popov, L Quertenmont, M Selvaggi, M Vidal Marono, N Beliy, G H Hammad, W L Aldá Júnior, F L Alves, G A Alves, L Brito, M Correa Martins Junior, M Hamer, C Hensel, C Mora Herrera, A Moraes, M E Pol, P Rebello Teles, E Belchior Batista Das Chagas, W Carvalho, J Chinellato, A Custódio, E M Da Costa, D De Jesus Damiao, C De Oliveira Martins, S Fonseca De Souza, L M Huertas Guativa, H Malbouisson, D Matos Figueiredo, L Mundim, H Nogima, W L Prado Da Silva, A Santoro, A Sznajder, E J Tonelli Manganote, A Vilela Pereira, S Ahuja, C A Bernardes, A De Souza Santos, S Dogra, T R Fernandez Perez Tomei, E M Gregores, P G Mercadante, C S Moon, S F Novaes, Sandra S Padula, D Romero Abad, J C Ruiz Vargas, A Aleksandrov, R Hadjiiska, P Iaydjiev, M Rodozov, S Stoykova, G Sultanov, M Vutova, A Dimitrov, I Glushkov, L Litov, B Pavlov, P Petkov, M Ahmad, J G Bian, G M Chen, H S Chen, M Chen, T Cheng, R Du, C H Jiang, R Plestina, F Romeo, S M Shaheen, A Spiezia, J Tao, C Wang, Z Wang, H Zhang, C Asawatangtrakuldee, Y Ban, Q Li, S Liu, Y Mao, S J Qian, D Wang, Z Xu, C Avila, A Cabrera, L F Chaparro Sierra, C Florez, J P Gomez, B Gomez Moreno, J C Sanabria, N Godinovic, D Lelas, I Puljak, P M Ribeiro Cipriano, Z Antunovic, M Kovac, V Brigljevic, K Kadija, J Luetic, S Micanovic, L Sudic, A Attikis, G Mavromanolakis, J Mousa, C Nicolaou, F Ptochos, P A Razis, H Rykaczewski, M Bodlak, M Finger, M Finger, A A Abdelalim, A Awad, M El Sawy, A Mahrous, A Radi, B Calpas, M Kadastik, M Murumaa, M Raidal, A Tiko, C Veelken, P Eerola, J Pekkanen, M Voutilainen, J Härkönen, V Karimäki, R Kinnunen, T Lampén, K Lassila-Perini, S Lehti, T Lindén, P Luukka, T Mäenpää, T Peltola, E Tuominen, J Tuominiemi, E Tuovinen, L Wendland, J Talvitie, T Tuuva, M Besancon, F Couderc, M Dejardin, D Denegri, B Fabbro, J L Faure, C Favaro, F Ferri, S Ganjour, A Givernaud, P Gras, G Hamel de Monchenault, P Jarry, E Locci, M Machet, J Malcles, J Rander, A Rosowsky, M Titov, A Zghiche, I Antropov, S Baffioni, F Beaudette, P Busson, L Cadamuro, E Chapon, C Charlot, T Dahms, O Davignon, N Filipovic, A Florent, R Granier de Cassagnac, S Lisniak, L Mastrolorenzo, P Miné, I N Naranjo, M Nguyen, C Ochando, G Ortona, P Paganini, P Pigard, S Regnard, R Salerno, J B Sauvan, Y Sirois, T Strebler, Y Yilmaz, A Zabi, J-L Agram, J Andrea, A Aubin, D Bloch, J-M Brom, M Buttignol, E C Chabert, N Chanon, C Collard, E Conte, X Coubez, J-C Fontaine, D Gelé, U Goerlach, C Goetzmann, A-C Le Bihan, J A Merlin, K Skovpen, P Van Hove, S Gadrat, S Beauceron, C Bernet, G Boudoul, E Bouvier, C A Carrillo Montoya, R Chierici, D Contardo, B Courbon, P Depasse, H El Mamouni, J Fan, J Fay, S Gascon, M Gouzevitch, B Ille, F Lagarde, I B Laktineh, M Lethuillier, L Mirabito, A L Pequegnot, S Perries, J D Ruiz Alvarez, D Sabes, L Sgandurra, V Sordini, M Vander Donckt, P Verdier, S Viret, T Toriashvili, Z Tsamalaidze, C Autermann, S Beranek, M Edelhoff, L Feld, A Heister, M K Kiesel, K Klein, M Lipinski, A Ostapchuk, M Preuten, F Raupach, S Schael, J F Schulte, T Verlage, H Weber, B Wittmer, V Zhukov, M Ata, M Brodski, E Dietz-Laursonn, D Duchardt, M Endres, M Erdmann, S Erdweg, T Esch, R Fischer, A Güth, T Hebbeker, C Heidemann, K Hoepfner, D Klingebiel, S Knutzen, P Kreuzer, M Merschmeyer, A Meyer, P Millet, M Olschewski, K Padeken, P Papacz, T Pook, M Radziej, H Reithler, M Rieger, F Scheuch, L Sonnenschein, D Teyssier, S Thüer, V Cherepanov, Y Erdogan, G Flügge, H Geenen, M Geisler, F Hoehle, B Kargoll, T Kress, Y Kuessel, A Künsken, J Lingemann, A Nehrkorn, A Nowack, I M Nugent, C Pistone, O Pooth, A Stahl, M Aldaya Martin, I Asin, N Bartosik, O Behnke, U Behrens, A J Bell, K Borras, A Burgmeier, A Campbell, S Choudhury, F Costanza, C Diez Pardos, G Dolinska, S Dooling, T Dorland, G Eckerlin, D Eckstein, T Eichhorn, G Flucke, E Gallo, J Garay Garcia, A Geiser, A Gizhko, P Gunnellini, J Hauk, M Hempel, H Jung, A Kalogeropoulos, O Karacheban, M Kasemann, P Katsas, J Kieseler, C Kleinwort, I Korol, W Lange, J Leonard, K Lipka, A Lobanov, W Lohmann, R Mankel, I Marfin, I-A Melzer-Pellmann, A B Meyer, G Mittag, J Mnich, A Mussgiller, S Naumann-Emme, A Nayak, E Ntomari, H Perrey, D Pitzl, R Placakyte, A Raspereza, B Roland, M Ö Sahin, P Saxena, T Schoerner-Sadenius, M Schröder, C Seitz, S Spannagel, K D Trippkewitz, R Walsh, C Wissing, V Blobel, M Centis Vignali, A R Draeger, J Erfle, E Garutti, K Goebel, D Gonzalez, M Görner, J Haller, M Hoffmann, R S Höing, A Junkes, R Klanner, R Kogler, N Kovalchuk, T Lapsien, T Lenz, I Marchesini, D Marconi, M Meyer, D Nowatschin, J Ott, F Pantaleo, T Peiffer, A Perieanu, N Pietsch, J Poehlsen, D Rathjens, C Sander, C Scharf, H Schettler, P Schleper, E Schlieckau, A Schmidt, J Schwandt, V Sola, H Stadie, G Steinbrück, H Tholen, D Troendle, E Usai, L Vanelderen, A Vanhoefer, B Vormwald, M Akbiyik, C Barth, C Baus, J Berger, C Böser, E Butz, T Chwalek, F Colombo, W De Boer, A Descroix, A Dierlamm, S Fink, F Frensch, R Friese, M Giffels, A Gilbert, D Haitz, F Hartmann, S M Heindl, U Husemann, I Katkov, A Kornmayer, P Lobelle Pardo, B Maier, H Mildner, M U Mozer, T Müller, Th Müller, M Plagge, G Quast, K Rabbertz, S Röcker, F Roscher, G Sieber, H J Simonis, F M Stober, R Ulrich, J Wagner-Kuhr, S Wayand, M Weber, T Weiler, C Wöhrmann, R Wolf, G Anagnostou, G Daskalakis, T Geralis, V A Giakoumopoulou, A Kyriakis, D Loukas, A Psallidas, I Topsis-Giotis, A Agapitos, S Kesisoglou, A Panagiotou, N Saoulidou, E Tziaferi, I Evangelou, G Flouris, C Foudas, P Kokkas, N Loukas, N Manthos, I Papadopoulos, E Paradas, J Strologas, G Bencze, C Hajdu, A Hazi, P Hidas, D Horvath, F Sikler, V Veszpremi, G Vesztergombi, A J Zsigmond, N Beni, S Czellar, J Karancsi, J Molnar, Z Szillasi, M Bartók, A Makovec, P Raics, Z L Trocsanyi, B Ujvari, P Mal, K Mandal, D K Sahoo, N Sahoo, S K Swain, S Bansal, S B Beri, V Bhatnagar, R Chawla, R Gupta, U Bhawandeep, A K Kalsi, A Kaur, M Kaur, R Kumar, A Mehta, M Mittal, J B Singh, G Walia, Ashok Kumar, A Bhardwaj, B C Choudhary, R B Garg, A Kumar, S Malhotra, M Naimuddin, N Nishu, K Ranjan, R Sharma, V Sharma, S Bhattacharya, K Chatterjee, S Dey, S Dutta, Sa Jain, N Majumdar, A Modak, K Mondal, S Mukherjee, S Mukhopadhyay, A Roy, D Roy, S Roy Chowdhury, S Sarkar, M Sharan, A Abdulsalam, R Chudasama, D Dutta, V Jha, V Kumar, A K Mohanty, L M Pant, P Shukla, A Topkar, T Aziz, S Banerjee, S Bhowmik, R M Chatterjee, R K Dewanjee, S Dugad, S Ganguly, S Ghosh, M Guchait, A Gurtu, G Kole, S Kumar, B Mahakud, M Maity, G Majumder, K Mazumdar, S Mitra, G B Mohanty, B Parida, T Sarkar, N Sur, B Sutar, N Wickramage, S Chauhan, S Dube, K Kothekar, S Sharma, H Bakhshiansohi, H Behnamian, S M Etesami, A Fahim, R Goldouzian, M Khakzad, M Mohammadi Najafabadi, M Naseri, S Paktinat Mehdiabadi, F Rezaei Hosseinabadi, B Safarzadeh, M Zeinali, M Felcini, M Grunewald, M Abbrescia, C Calabria, C Caputo, A Colaleo, D Creanza, L Cristella, N De Filippis, M De Palma, L Fiore, G Iaselli, G Maggi, M Maggi, G Miniello, S My, S Nuzzo, A Pompili, G Pugliese, R Radogna, A Ranieri, G Selvaggi, L Silvestris, R Venditti, P Verwilligen, G Abbiendi, C Battilana, A C Benvenuti, D Bonacorsi, S Braibant-Giacomelli, L Brigliadori, R Campanini, P Capiluppi, A Castro, F R Cavallo, S S Chhibra, G Codispoti, M Cuffiani, G M Dallavalle, F Fabbri, A Fanfani, D Fasanella, P Giacomelli, C Grandi, L Guiducci, S Marcellini, G Masetti, A Montanari, F L Navarria, A 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Eshaq, T Ferbel, M Galanti, A Garcia-Bellido, J Han, A Harel, O Hindrichs, A Khukhunaishvili, G Petrillo, P Tan, M Verzetti, S Arora, A Barker, J P Chou, C Contreras-Campana, E Contreras-Campana, D Duggan, D Ferencek, Y Gershtein, R Gray, E Halkiadakis, D Hidas, E Hughes, S Kaplan, R Kunnawalkam Elayavalli, A Lath, K Nash, S Panwalkar, M Park, S Salur, S Schnetzer, D Sheffield, S Somalwar, R Stone, S Thomas, P Thomassen, M Walker, M Foerster, G Riley, K Rose, S Spanier, A York, O Bouhali, A Castaneda Hernandez, M Dalchenko, M De Mattia, A Delgado, S Dildick, R Eusebi, J Gilmore, T Kamon, V Krutelyov, R Mueller, I Osipenkov, Y Pakhotin, R Patel, A Perloff, A Rose, A Safonov, A Tatarinov, K A Ulmer, N Akchurin, C Cowden, J Damgov, C Dragoiu, P R Dudero, J Faulkner, S Kunori, K Lamichhane, S W Lee, T Libeiro, S Undleeb, I Volobouev, E Appelt, A G Delannoy, S Greene, A Gurrola, R Janjam, W Johns, C Maguire, Y Mao, A Melo, H Ni, P Sheldon, B Snook, S Tuo, J Velkovska, Q Xu, M W Arenton, B Cox, B Francis, J Goodell, R Hirosky, A Ledovskoy, H Li, C Lin, C Neu, T Sinthuprasith, X Sun, Y Wang, E Wolfe, J Wood, F Xia, C Clarke, R Harr, P E Karchin, C Kottachchi Kankanamge Don, P Lamichhane, J Sturdy, D A Belknap, D Carlsmith, M Cepeda, S Dasu, L Dodd, S Duric, B Gomber, M Grothe, R Hall-Wilton, M Herndon, A Hervé, P Klabbers, A Lanaro, A Levine, K Long, R Loveless, A Mohapatra, I Ojalvo, T Perry, G A Pierro, G Polese, T Ruggles, T Sarangi, A Savin, A Sharma, N Smith, W H Smith, D Taylor, N Woods
A measurement of the top quark pair production ([Formula: see text]) cross section in proton-proton collisions at the centre-of-mass energy of 8[Formula: see text] is presented using data collected with the CMS detector at the LHC, corresponding to an integrated luminosity of 19.6[Formula: see text]. This analysis is performed in the [Formula: see text] decay channels with one isolated, high transverse momentum electron or muon and at least four jets, at least one of which is required to be identified as originating from hadronization of a b quark...
2017: European Physical Journal. C, Particles and Fields
https://www.readbyqxmd.com/read/28258984/application-of-design-space-optimization-strategy-to-the-development-of-lc-methods-for-simultaneous-analysis-of-18-antiretroviral-medicines-and-4-major-excipients-used-in-various-pharmaceutical-formulations
#18
Védaste Habyalimana, Jérémie Kindenge Mbinze, Achille Loconon Yemoa, Christelle Waffo, Tidiane Diallo, Nicodème Kalenda Tshilombo, Justin-Léonard Kadima Ntokamunda, Pierre Lebrun, Philippe Hubert, Roland Djang'eing'a Marini
As one of the world's most significant public health challenges in low- and middle-income countries, HIV/AIDS deserves to be treated with appropriate medicines, however which are not spared from counterfeiting. For that, we developed screening and specific HPLC methods that can analyze 18 antiretroviral medicines (ARV) and 4 major excipients. Design of experiments and design space methodology were initially applied for 15 ARV and the 4 excipients with prediction thanks to Monte Carlo simulations and focusing on rapidity and affordability thus using short column and low cost organic solvent (methanol) in gradient mode with 10mM buffer solutions of ammonium hydrogen carbonate...
February 24, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28257120/glycerol-as-precursor-of-organoselanyl-and-organotellanyl-alkynes
#19
Eder J Lenardão, Elton L Borges, Guilherme Stach, Liane K Soares, Diego Alves, Ricardo F Schumacher, Luana Bagnoli, Francesca Marini, Gelson Perin
Herein we describe the synthesis of organoselanyl and organotellanyl alkynes by the addition of lithium alkynylchalcogenolate (Se and Te) to tosyl solketal, easily obtained from glycerol. The alkynylchalcogenolate anions were generated in situ and added to tosyl solketal in short reaction times, furnishing in all cases the respective products of substitution in good yields. Some of the prepared compounds were deprotected using an acidic resin to afford new water-soluble 3-organotellanylpropane-1,2-diols. The synthetic versatility of the new chalcogenyl alkynes was demonstrated in the iodocyclization of 2,2-dimethyl-1,3-dioxolanylmethyl(2-methoxyphenylethynyl)selane 3f, which afforded 3-iodo-2-(2,2-dimethyl-1,3-dioxolanylmethyl) selenanylbenzo[b]furan in 85% yield, opening a new way to access water-soluble Se-functionalized benzo[b]furanes...
March 2, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28250420/a-fully-organic-retinal-prosthesis-restores-vision-in-a-rat-model-of-degenerative-blindness
#20
José Fernando Maya-Vetencourt, Diego Ghezzi, Maria Rosa Antognazza, Elisabetta Colombo, Maurizio Mete, Paul Feyen, Andrea Desii, Ambra Buschiazzo, Mattia Di Paolo, Stefano Di Marco, Flavia Ticconi, Laura Emionite, Dmytro Shmal, Cecilia Marini, Ilaria Donelli, Giuliano Freddi, Rita Maccarone, Silvia Bisti, Gianmario Sambuceti, Grazia Pertile, Guglielmo Lanzani, Fabio Benfenati
The degeneration of photoreceptors in the retina is one of the major causes of adult blindness in humans. Unfortunately, no effective clinical treatments exist for the majority of retinal degenerative disorders. Here we report on the fabrication and functional validation of a fully organic prosthesis for long-term in vivo subretinal implantation in the eye of Royal College of Surgeons rats, a widely recognized model of retinitis pigmentosa. Electrophysiological and behavioural analyses reveal a prosthesis-dependent recovery of light sensitivity and visual acuity that persists up to 6-10 months after surgery...
March 6, 2017: Nature Materials
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