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https://www.readbyqxmd.com/read/28074228/ventilation-induced-lung-injury-exists-in-spontaneously-breathing-patients-with-acute-respiratory-failure-yes
#1
EDITORIAL
Laurent Brochard
No abstract text is available yet for this article.
January 10, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28029545/highly-sensitive-lc-ms-ms-methods-for-urinary-biological-monitoring-of-occupational-exposure-to-cyclophosphamide-ifosfamide-and-methotrexate-antineoplastic-drugs-and-routine-application
#2
Mireille Canal-Raffin, Karim Khennoufa, Béatrice Martinez, Yves Goujon, Celia Folch, Dominique Ducint, Karine Titier, Patrick Brochard, Catherine Verdun-Esquer, Mathieu Molimard
Highly sensitive ESI-LC-MS/MS methods were developed for urinary biological monitoring of occupational exposure to cyclophosphamide (CP), ifosfamide (IF), and methotrexate (MTX), which are hazardous antineoplastic drugs frequently handled by healthcare professionals. Extraction methods consisted of liquid/liquid extraction for simultaneous urinary CP and IF assays, and of solid phase extraction for the urinary MTX assay. A good linearity (r2>0.997), precision (CV<14.6%), and accuracy (bias<9.9%) were achieved for all compounds...
October 21, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28027085/bispectral-index-can-reliably-detect-deep-sedation-in-mechanically-ventilated-patients-a-prospective-multicenter-validation-study
#3
Zhu-Heng Wang, Han Chen, Yan-Lin Yang, Zhong-Hua Shi, Qing-Hua Guo, Yu-Wei Li, Li-Ping Sun, Wei Qiao, Guan-Hua Zhou, Rong-Guo Yu, Kai Yin, Xuan He, Ming Xu, Laurent J Brochard, Jian-Xin Zhou
BACKGROUND: Excessively deep sedation is prevalent in mechanically ventilated patients and often considered suboptimal. We hypothesized that the bispectral index (BIS), a quantified electroencephalogram instrument, would accurately detect deep levels of sedation. METHODS: We prospectively enrolled 90 critically ill mechanically ventilated patients who were receiving sedation. The BIS was monitored for 24 hours and compared with the Richmond Agitation Sedation Scale (RASS) evaluated every 4 hours...
December 22, 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27987468/neurotomy-of-the-rectus-femoris-nerve-short-term-effectiveness-for-spastic-stiff-knee-gait-clinical-assessment-and-quantitative-gait-analysis
#4
R Gross, J Robertson, F Leboeuf, O Hamel, S Brochard, B Perrouin-Verbe
BACKGROUND: Stiff knee gait is a troublesome gait disturbance related to spastic paresis, frequently associated with overactivity of the rectus femoris muscle in the swing phase of gait. OBJECTIVE: The aim of this study was to assess the short-term effects of rectus femoris neurotomy for the treatment of spastic stiff-knee gait in patients with hemiparesis. PATIENTS AND METHODS: An Intervention study (before-after trial) with an observational design was carried out in a university hospital...
November 19, 2016: Gait & Posture
https://www.readbyqxmd.com/read/27973930/comorbidities-and-subgroups-of-patients-surviving-severe-acute-hypercapnic-respiratory-failure-in-the-icu
#5
Dan Adler, Jean-Louis Pépin, Elise Dupuis-Lozeron, Katerina Espa-Cervena, Roselyne Merlet-Violet, Hajo Muller, Jean-Paul Janssens, Laurent Brochard
RATIONALE: No methodical assessment of the lung, cardiac and sleep function of patients surviving an acute hypercapnic respiratory failure episode requiring admission to the intensive care unit (ICU) has been reported in the literature. OBJECTIVES: To prospectively investigate the prevalence and impact of comorbidities in patients treated by mechanical ventilator support (invasive or non-invasive) for acute hypercapnic respiratory failure in the ICU. METHODS: Seventy-eight consecutive patients admitted for an episode of acute hypercapnic respiratory failure underwent an assessment of lung, cardiac and sleep function by pulmonary function tests, transthoracic echocardiography and polysomnography 3 months after ICU discharge...
December 14, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27969245/le-lavement-rectal-syst%C3%A3-matique-avant-cystomanom%C3%A3-trie-n%C3%A2-a-pas-d%C3%A2-influence-sur-la-qualit%C3%A3-de-la-courbe-de-pression-abdominale%C3%A2-r%C3%A3-sultat-d%C3%A2-une-%C3%A3-tude-prospective-contr%C3%A3-l%C3%A3-e
#6
B Peyronnet, H Rigole, N Senal, A Manunta, A Manunta, C Brochard, L Tondut, L Tondut, Q Alimi, L Siproudhis, L Siproudhis, L Siproudhis, K Bensalah, M Damphousse, J Kerdraon, I Bonan
No abstract text is available yet for this article.
November 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27969205/%C3%A3-pid%C3%A3-miologie-du-spina-bifida-en-france
#7
B Peyronnet, F Gao, C Brochard, E Oger, H Menard, A Arnaud, J Hascoet, J Kerdraon, L Siproudhis, X Game, A Manunta
No abstract text is available yet for this article.
November 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27969204/comparaison-des-neurovessies-des-dysraphismes-ferm%C3%A3-s-et-ouverts%C3%A2-r%C3%A3-sultats-observ%C3%A3-s-sur-une-cohorte-prospective-de-395%C3%A2-patients
#8
B Peyronnet, C Brochard, M Jezequel, H Menard, J Hascoet, N Senal, I Bonan, A Arnaud, L Siproudhis, J Kerdraon, X Game, A Manunta
No abstract text is available yet for this article.
November 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27875410/should-we-use-driving-pressure-to-set-tidal-volume
#9
Domenico L Grieco, Lu Chen, Martin Dres, Laurent Brochard
PURPOSE OF REVIEW: Ventilator-induced lung injury (VILI) can occur despite use of tidal volume (VT) limited to 6 ml/kg of predicted body weight, especially in patients with a smaller aerated compartment (i.e. the baby lung) in which, indeed, tidal ventilation takes place. Because respiratory system static compliance (CRS) is mostly affected by the volume of the baby lung, the ratio VT/CRS (i.e. the driving pressure, ΔP) may potentially help tailoring interventions on VT setting. RECENT FINDINGS: Driving pressure is the ventilatory variable most strongly associated with changes in survival and has been shown to be the key mediator of the effects of mechanical ventilation on outcome in the acute respiratory distress syndrome...
February 2017: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/27873306/activated-leukocyte-cell-adhesion-molecule-alcam-is-a-marker-of-recurrence-and-promotes-cell-migration-invasion-and-metastasis-in-early-stage-endometrioid-endometrial-cancer
#10
Laura Devis, Cristian P Moiola, Nuria Masia, Elena Martinez-Garcia, Maria Santacana, Tomita Vasilica Stirbat, Françoise Brochard-Wyart, Ángel García, Francesc Alameda, Silvia Cabrera, Jose Palacios, Gema Moreno-Bueno, Miguel Abal, William Thomas, Sylvie Dufour, Xavier Matias-Guiu, Anna Santamaria, Jaume Reventos, Antonio Gil-Moreno, Eva Colas
Endometrial cancer is the most common gynaecological cancer in western countries, being the most common subtype of endometrioid tumours. Most patients are diagnosed at an early stage and present an excellent prognosis. However, a number of those continue to suffer recurrence, without means of identification by risk classification systems. Thus, finding a reliable marker to predict recurrence becomes an important unmet clinical issue. ALCAM is a cell-cell adhesion molecule and member of the Immunoglobulin superfamily that has been associated with genesis of many cancers...
November 22, 2016: Journal of Pathology
https://www.readbyqxmd.com/read/27866118/pathological-and-physiological-muscle-co-activation-during-active-elbow-extension-in-children-with-unilateral-cerebral-palsy
#11
A Sarcher, M Raison, F Leboeuf, B Perrouin-Verbe, S Brochard, R Gross
OBJECTIVE: To address the roles and mechanisms of co-activation in two flexor/extensor pairs during elbow extension in children with cerebral palsy (CP). METHODS: 13 Typically Developing (TD) and 13 children with unilateral spastic CP performed elbow extension/flexion at different speeds. Elbow angle and velocity were recorded using a 3D motion analysis system. The acceleration and deceleration phases of extension were analyzed. Co-activation of the brachioradialis/triceps and biceps/triceps pairs was computed for each phase from surface electromyographic signals...
January 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/27784322/spontaneous-breathing-trial-and-post-extubation-work-of-breathing-in-morbidly-obese-critically-ill-patients
#12
Martin Mahul, Boris Jung, Fabrice Galia, Nicolas Molinari, Audrey de Jong, Yannaël Coisel, Rosanna Vaschetto, Stefan Matecki, Gérald Chanques, Laurent Brochard, Samir Jaber
BACKGROUND: Predicting whether an obese critically ill patient can be successfully extubated may be specially challenging. Several weaning tests have been described but no physiological study has evaluated the weaning test that would best reflect the post-extubation inspiratory effort. METHODS: This was a physiological randomized crossover study in a medical and surgical single-center Intensive Care Unit, in patients with body mass index (BMI) >35 kg/m(2) who were mechanically ventilated for more than 24 h and underwent a weaning test...
October 27, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27776992/routine-enema-before-urodynamics-has-no-impact-on-the-quality-of-abdominal-pressure-curves-results-of-a-prospective-controlled-study
#13
H Rigole, N Senal, M Damphousse, C Brochard, A Manunta, J Kerdraon, L Tondut, Q Alimi, J Hascoet, L Siproudhis, B Peyronnet, I Bonan
AIMS: The presence of stools in the rectum might affect the quality of the abdominal pressure curve during filling cystometry, but, to date, no study has evaluated the impact of bowel preparation before urodynamics. We evaluated the influence of a sodium phosphate enema before urodynamics on the quality of the abdominal pressure curve. METHODS: A prospective, controlled, single-blind study was conducted in a single center from May to June 2013. The patients were divided into 2 consecutive groups: patients seen in outpatient clinics during the first 6 weeks (group A) who underwent urodynamics without bowel preparation and patients seen in outpatient clinics during the second 6 weeks (group B) who had a prescription of sodium phosphate enema before urodynamics...
December 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27768396/effort-to-breathe-with-various-spontaneous-breathing-trial-techniques-a-physiological-meta-analysis
#14
Michael C Sklar, Karen Burns, Nuttapol Rittayamai, Ashley Lanys, Michela Rauseo, Lu Chen, Martin Dres, Guang-Qiang Chen, Ewan C Goligher, Neill Kj Adhikari, Laurent Brochard, Jan O Friedrich
Introduction Spontaneous breathing trials (SBTs) are designed to simulate conditions following extubation and it is essential to understand the physiological impact of different methods. We conducted a systematic review and pooled measures reflecting patient respiratory effort among studies comparing SBT methods in a meta-analysis. Methods We searched Medline, EMBASE, and Web of Science from inception to January 2016 to identify randomized and non-randomized clinical trials reporting physiological measurements of respiratory effort (pressure-time product, PTP) or work of breathing during at least 2 SBT techniques...
October 21, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27757516/potentially-modifiable-factors-contributing-to-outcome-from-acute-respiratory-distress-syndrome-the-lung-safe-study
#15
John G Laffey, Giacomo Bellani, Tài Pham, Eddy Fan, Fabiana Madotto, Ednan K Bajwa, Laurent Brochard, Kevin Clarkson, Andres Esteban, Luciano Gattinoni, Frank van Haren, Leo M Heunks, Kiyoyasu Kurahashi, Jon Henrik Laake, Anders Larsson, Daniel F McAuley, Lia McNamee, Nicolas Nin, Haibo Qiu, Marco Ranieri, Gordon D Rubenfeld, B Taylor Thompson, Hermann Wrigge, Arthur S Slutsky, Antonio Pesenti
PURPOSE: To improve the outcome of the acute respiratory distress syndrome (ARDS), one needs to identify potentially modifiable factors associated with mortality. METHODS: The large observational study to understand the global impact of severe acute respiratory failure (LUNG SAFE) was an international, multicenter, prospective cohort study of patients with severe respiratory failure, conducted in the winter of 2014 in a convenience sample of 459 ICUs from 50 countries across five continents...
October 18, 2016: Intensive Care Medicine
https://www.readbyqxmd.com/read/27753501/noninvasive-ventilation-of-patients-with-acute-respiratory-distress-syndrome-insights-from-the-lung-safe-study
#16
Giacomo Bellani, John G Laffey, Tài Pham, Fabiana Madotto, Eddy Fan, Laurent Brochard, Andres Esteban, Luciano Gattinoni, Vesna Bumbasirevic, Lise Piquilloud, Frank van Haren, Anders Larsson, Daniel F McAuley, Philippe R Bauer, Yaseen M Arabi, Marco Ranieri, Massimo Antonelli, Gordon D Rubenfeld, B Taylor Thompson, Hermann Wrigge, Arthur S Slutsky, Antonio Pesenti
RATIONALE: Noninvasive ventilation (NIV) is increasingly used in patients with acute respiratory distress syndrome (ARDS). The evidence supporting NIV use in patients with ARDS remains relatively sparse. OBJECTIVES: To determine whether, during NIV, the categorization of ARDS severity based on the PaO2/FiO2 Berlin criteria is useful. METHODS: The LUNG SAFE (Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure) study described the management of patients with ARDS...
January 1, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27748627/partial-neuromuscular-blockade-during-partial-ventilatory-support-in-sedated-patients-with-high-tidal-volumes
#17
Jonne Doorduin, Joeke L Nollet, Lisanne H Roesthuis, Hieronymus W H van Hees, Laurent J Brochard, Christer A Sinderby, Johannes G van der Hoeven, Leo M A Heunks
RATIONALE: Controlled mechanical ventilation is used to deliver lung-protective ventilation in patients with acute respiratory distress syndrome. Despite recognized benefits, such as preserved diaphragm activity, partial support ventilation modes may be incompatible with lung-protective ventilation due to high tidal volume and high transpulmonary pressure. As an alternative to high dose sedatives and controlled mechanical ventilation, pharmacologically induced neuromechanical uncoupling of the diaphragm should facilitate lung-protective ventilation under partial support modes...
October 17, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27747049/high-flow-nasal-cannula-in-postextubation-management
#18
COMMENT
Lu Chen, Hong-Liang Li, Laurent Brochard
No abstract text is available yet for this article.
September 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27736154/a-multicenter-randomized-trial-assessing-the-efficacy-of-helium-oxygen-in-severe-exacerbations-of-chronic-obstructive-pulmonary-disease
#19
Philippe Jolliet, Lamia Ouanes-Besbes, Fekri Abroug, Jalila Ben Khelil, Mohamed Besbes, Aude Garnero, Jean-Michel Arnal, Fabrice Daviaud, Jean-Daniel Chiche, Benoît Lortat-Jacob, Jean-Luc Diehl, Nicolas Lerolle, Alain Mercat, Keyvan Razazi, Christian Brun-Buisson, Isabelle Durand-Zaleski, Joëlle Texereau, Laurent Brochard
RATIONALE: During non-invasive ventilation (NIV) for COPD exacerbations, Helium/Oxygen (He/O2) reduces work of breathing and hypercapnia more than Air/O2 but impact on clinical outcome remains unknown. OBJECTIVE: To determine whether continuous administration of He/O2 for 72 hours, during and in-between NIV sessions, is superior to Air/O2 in reducing NIV failure (25% to 15%) in severe hypercapnic COPD exacerbations. METHODS: Prospective, randomized, open-label trial (16 intensive care units, 6 countries)...
October 13, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27714338/nanostickers-for-cells-a-model-study-using-cell-nanoparticle-hybrid-aggregates
#20
Benjamin Brunel, Grégory Beaune, Usharani Nagarajan, Sylvie Dufour, Françoise Brochard-Wyart, Françoise M Winnik
We present direct evidence that nanoparticles (NPs) can stick together cells that are inherently non-adhesive. Using cadherin-depleted S180 murine cells lines, which exhibit very low cell-cell adhesion, we show that NPs can assemble dispersed single cells into large cohesive aggregates. The dynamics of aggregation, which is controlled by diffusion and collision, can be described as a second-order kinetic law characterized by a rate of collision that depends on the size, concentration, and surface chemistry of the NPs...
September 28, 2016: Soft Matter
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