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https://www.readbyqxmd.com/read/29355550/research-in-extracorporeal-life-support-a-call-to-action
#1
Daniel Brodie, Vincent Jean-Louis, Laurent J Brochard, Alain Combes, Niall D Ferguson, Carol L Hodgson, John G Laffey, Alain Mercat, Antonio Pesenti, Michael Quintel, Arthur S Slutsky, V Marco Ranieri
No abstract text is available yet for this article.
January 17, 2018: Chest
https://www.readbyqxmd.com/read/29350241/the-airway-occlusion-pressure-p0-1-to-monitor-respiratory-drive-during-mechanical-ventilation-increasing-awareness-of-a-not-so-new-problem
#2
Irene Telias, Felipe Damiani, Laurent Brochard
No abstract text is available yet for this article.
January 19, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/29347110/influence-of-a-dispersion-of-magnetic-and-nonmagnetic-nanoparticles-on-the-magnetic-fredericksz-transition-of-the-liquid-crystal-5cb
#3
Ahmed Mouhli, Habib Ayeb, Tahar Othman, Jérôme Fresnais, Vincent Dupuis, Ian R Nemitz, Joel S Pendery, Charles Rosenblatt, Olivier Sandre, Emmanuelle Lacaze
A long time ago, Brochard and de Gennes predicted the possibility of significantly decreasing the critical magnetic field of the Fredericksz transition (the magnetic Fredericksz threshold) in a mixture of nematic liquid crystals and ferromagnetic particles, the so-called ferronematics. This phenomenon is rarely measured to be large, due to soft homeotropic anchoring induced at the nanoparticle surface. Here we present an optical study of the magnetic Fredericksz transition combined with a light scattering study of the classical nematic liquid crystal: the pentylcyanobiphenyl (5CB), doped with 6 nm diameter magnetic and nonmagnetic nanoparticles...
July 2017: Physical Review. E
https://www.readbyqxmd.com/read/29330683/cardiac-function-during-weaning-failure-the-role-of-diastolic-dysfunction
#4
Ferran Roche-Campo, Alexandre Bedet, Emmanuel Vivier, Laurent Brochard, Armand Mekontso Dessap
BACKGROUND: Cardiac dysfunction is a common cause of weaning failure. Weaning shares some similarities with a cardiac stress test and may challenge active phases of the cardiac cycle-like ventricular contractility and relaxation. This study aimed at assessing systolic and diastolic function during the weaning process and scrutinizing their dynamics during weaning trials. METHODS: Echocardiography was performed during baseline ventilator settings to assess cardiac function at the initiation of the weaning process and at the start and the end of consecutive weaning trials (performed at day-1, day-2, and before extubation if applicable) to explore the evolution of left ventricle contractility and relaxation in a subset of patients...
January 9, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29323931/esophageal-manometry-and-regional-transpulmonary-pressure-in-lung-injury
#5
Takeshi Yoshida, Marcelo B P Amato, Domenico Luca Grieco, Lu Chen, Cristhiano A S Lima, Rollin Roldan, Caio C A Morais, Susimeire Gomes, Eduardo L V Costa, Paulo F G Cardoso, Emmanuel Charbonney, Jean-Christophe M Richard, Laurent Brochard, Brian P Kavanagh
RATIONALE: Esophageal manometry is the clinically available method to estimate pleural pressure, thus enabling calculation of the transpulmonary pressure (PL). However, many concerns make uncertain in which lung region esophageal manometry reflects local PL. OBJECTIVES: To determine the accuracy of esophageal pressure (Pes) and in which regions esophageal manometry reflects Ppl and PL; to assess whether lung stress in non-dependent regions can be estimated at end-inspiration from PL...
January 11, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29317351/a-new-physiological-model-for-studying-the-effect-of-chest-compression-and-ventilation-during-cardiopulmonary-resuscitation-the-thiel-cadaver
#6
Emmanuel Charbonney, Stéphane Delisle, Dominique Savary, Gilles Bronchti, Marceau Rigollot, Adrien Drouet, Bilal Badat, Paul Ouellet, Patrice Gosselin, Alain Mercat, Laurent Brochard, Jean-Christophe M Richard
BACKGROUND: Studying ventilation and intrathoracic pressure (ITP) induced by chest compressions (CC) during Cardio Pulmonary Resuscitation is challenging and important aspects such as airway closure have been mostly ignored. We hypothesized that Thiel Embalmed Cadavers could constitute an appropriate model. METHODS: We assessed respiratory mechanics and ITP during CC in 11 cadavers, and we compared it to measurements obtained in 9 out-of-hospital cardiac arrest patients and to predicted values from a bench model...
January 6, 2018: Resuscitation
https://www.readbyqxmd.com/read/29316903/parental-reassurance-concerning-a-feverish-child-determinant-factors-in-rural-general-practice
#7
Anthony Chapron, Marc Brochard, Chloé Rousseau, Anne-Charlotte Rousseau, Martine Brujean, Laure Fiquet, Virginie Gandemer
BACKGROUND: Acute fever is the most common pediatric condition encountered in general practice and a source of parental concern that can result in inappropriate behavior. The main objective of this study was to describe and quantify parental reassurance concerning their feverish child in the context of visits to rural general practitioners (GPs). METHOD: The study included the parents of 202 feverish children, aged from 3 months to 6 years, consulting 13 representative rural GPs...
January 9, 2018: BMC Family Practice
https://www.readbyqxmd.com/read/29288113/early-botulinum-toxin-injections-in-infants-with-musculoskeletal-disorders-a-systematic-review-of-safety-and-effectiveness
#8
REVIEW
Jean-Sébastien Bourseul, Anais Molina, Mael Lintanf, Laetitia Houx, Emmanuelle Chaléat-Valayer, Christelle Pons, Sylvain Brochard
OBJECTIVE: To report current evidence regarding the safety of intramuscular BTI in children with orthopaedic- and neurological-related musculoskeletal disorders under the age of 2 years. DATA SOURCE: PUBMED, The Cochrane Library, and Science Direct, Google Scholar and Web of Science. STUDY SELECTION: Two reviewers independently selected studies based on predetermined inclusion criteria. DATA EXTRACTION: Data relating to the aim were extracted...
December 26, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29232401/dynamic-mri-to-quantify-musculoskeletal-motion-a-systematic-review-of-concurrent-validity-and-reliability-and-perspectives-for-evaluation-of-musculoskeletal-disorders
#9
Bhushan Borotikar, Mathieu Lempereur, Mathieu Lelievre, Valérie Burdin, Douraied Ben Salem, Sylvain Brochard
PURPOSE: To report evidence for the concurrent validity and reliability of dynamic MRI techniques to evaluate in vivo joint and muscle mechanics, and to propose recommendations for their use in the assessment of normal and impaired musculoskeletal function. MATERIALS AND METHODS: The search was conducted on articles published in Web of science, PubMed, Scopus, Academic search Premier, and Cochrane Library between 1990 and August 2017. Studies that reported the concurrent validity and/or reliability of dynamic MRI techniques for in vivo evaluation of joint or muscle mechanics were included after assessment by two independent reviewers...
2017: PloS One
https://www.readbyqxmd.com/read/29221238/protecting-lungs-during-spontaneous-breathing-what-can-we-do
#10
EDITORIAL
Hong-Liang Li, Lu Chen, Laurent Brochard
No abstract text is available yet for this article.
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29218379/a-prospective-international-observational-prevalence-study-on-prone-positioning-of-ards-patients-the-apronet-ards-prone-position-network-study
#11
C Guérin, P Beuret, J M Constantin, G Bellani, P Garcia-Olivares, O Roca, J H Meertens, P Azevedo Maia, T Becher, J Peterson, A Larsson, M Gurjar, Z Hajjej, F Kovari, A H Assiri, E Mainas, M S Hasan, D R Morocho-Tutillo, L Baboi, J M Chrétien, G François, L Ayzac, L Chen, L Brochard, A Mercat
INTRODUCTION: While prone positioning (PP) has been shown to improve patient survival in moderate to severe acute respiratory distress syndrome (ARDS) patients, the rate of application of PP in clinical practice still appears low. AIM: This study aimed to determine the prevalence of use of PP in ARDS patients (primary endpoint), the physiological effects of PP, and the reasons for not using it (secondary endpoints). METHODS: The APRONET study was a prospective international 1-day prevalence study performed four times in April, July, and October 2016 and January 2017...
December 7, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/29208005/recovery-after-critical-illness-putting-the-puzzle-together-a-consensus-of-29
#12
REVIEW
Elie Azoulay, Jean-Louis Vincent, Derek C Angus, Yaseen M Arabi, Laurent Brochard, Stephen J Brett, Giuseppe Citerio, Deborah J Cook, Jared Randall Curtis, Claudia C Dos Santos, E Wesley Ely, Jesse Hall, Scott D Halpern, Nicholas Hart, Ramona O Hopkins, Theodore J Iwashyna, Samir Jaber, Nicola Latronico, Sangeeta Mehta, Dale M Needham, Judith Nelson, Kathleen Puntillo, Michael Quintel, Kathy Rowan, Gordon Rubenfeld, Greet Van den Berghe, Johannes Van der Hoeven, Hannah Wunsch, Margaret Herridge
In this review, we seek to highlight how critical illness and critical care affect longer-term outcomes, to underline the contribution of ICU delirium to cognitive dysfunction several months after ICU discharge, to give new insights into ICU acquired weakness, to emphasize the importance of value-based healthcare, and to delineate the elements of family-centered care. This consensus of 29 also provides a perspective and a research agenda about post-ICU recovery.
December 5, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29191587/phenotypes-of-lung-cancer-and-statistical-interactions-between-tobacco-smoking-and-occupational-exposure-to-asbestos-and-crystalline-silica-from-a-large-case-only-study-the-capromat-study
#13
Mohamad El Zoghbi, Pascale Salameh, Isabelle Stücker, Christophe Paris, Jean Claude Pairon, Antoine Gislard, Jack Siemiatycki, Vincent Bonneterre, Bénédicte Clin, Patrick Brochard, Fleur Delva, Aude Lacourt
OBJECTIVES: The aim of this study was to assess the effect modification of the association between tobacco smoking and phenotypes of lung cancer (histological type, tumor location, and age at diagnosis) by occupational exposure to asbestos or to crystalline silica. MATERIALS AND METHODS: The CaProMat study is a pooled case-only study including 7256 male lung cancer cases recruited between 1996 and 2011 in France and Canada. Two job-exposure matrices (JEMs) were used to assess occupational exposure to asbestos and crystalline silica...
October 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29186671/reply-to-the-plausibility-of-bronchiolotrauma
#14
Lu Chen, Lorenzo Del Sorbo, Eddy Fan, Laurent Brochard
No abstract text is available yet for this article.
November 29, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29146990/how-gluttonous-cell-aggregates-clear-substrates-coated-with-microparticles
#15
Grégory Beaune, Andy Y W Lam, Sylvie Dufour, Françoise M Winnik, Françoise Brochard-Wyart
We study the spreading of cell aggregates deposited on adhesive substrates decorated with microparticles (MPs). A cell monolayer expands around the aggregate. The cells on the periphery of the monolayer take up the MPs, clearing the substrate as they progress and forming an aureole of cells filled with MPs. We study the dynamics of spreading and determine the width of the aureole and the level of MP internalization in cells as a function of MP size, composition, and density. From the radius and width of the aureole, we quantify the volume fraction of MPs within the cell, which leads to an easy, fast, and inexpensive measurement of the cell - particle internalization...
November 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29138899/correction-to-potentially-modifiable-factors-contributing-to-outcome-from-acute-respiratory-distress-syndrome-the-lung-safe-study
#16
John G Laffey, Giacomo Bellani, Tài Pham, Eddy Fan, Fabiana Madotto, Ednan K Bajwa, Laurent Brochard, Kevin Clarkson, Andres Esteban, Luciano Gattinoni, Frank van Haren, Leo M Heunks, Kiyoyasu Kurahashi, Jon Henrik Laake, Anders Larsson, Daniel F McAuley, Lia McNamee, Nicolas Nin, Haibo Qiu, Marco Ranieri, Gordon D Rubenfeld, B Taylor Thompson, Hermann Wrigge, Arthur S Slutsky, Antonio Pesenti
Correction to: Intensive Care Med (2016) 42:1865-1876 DOI 10.1007/s00134-016-4571-5.
November 14, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/29138898/correction-to-the-intensive-care-global-study-on-severe-acute-respiratory-infection-ic-glossari-a-multicenter-multinational-14-day-inception-cohort-study
#17
Yasser Sakr, Ricard Ferrer, Konrad Reinhart, Richard Beale, Andrew Rhodes, Rui Moreno, Jean Francois Timsit, Laurent Brochard, B Taylor Thompson, Ederlon Rezende, Jean Daniel Chiche
In both the original publication (DOI 10.1007/s00134-015-4206-2) and the first erratum (DOI 10.1007/s00134-016-4317-4), the members of the IC-GLOSSARI Investigators and the ESICM Trials Group were provided in such a way that they could not be indexed as collaborators on PubMed. The publisher apologizes for these errors and is pleased to list the members of the groups here.
November 14, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/29099420/predictors-of-intubation-in-patients-with-acute-hypoxemic-respiratory-failure-treated-with-a-noninvasive-oxygenation-strategy
#18
Jean-Pierre Frat, Stéphanie Ragot, Rémi Coudroy, Jean-Michel Constantin, Christophe Girault, Gwénael Prat, Thierry Boulain, Alexandre Demoule, Jean-Damien Ricard, Keyvan Razazi, Jean-Baptiste Lascarrou, Jérôme Devaquet, Jean-Paul Mira, Laurent Argaud, Jean-Charles Chakarian, Muriel Fartoukh, Saad Nseir, Alain Mercat, Laurent Brochard, René Robert, Arnaud W Thille
OBJECTIVES: In patients with acute hypoxemic respiratory failure, noninvasive ventilation and high-flow nasal cannula oxygen are alternative strategies to conventional oxygen therapy. Endotracheal intubation is frequently needed in these patients with a risk of delay, and early predictors of failure may help clinicians to decide early. We aimed to identify factors associated with intubation in patients with acute hypoxemic respiratory failure treated with different noninvasive oxygenation techniques...
November 2, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29095203/acute-respiratory-distress-syndrome-cases-volume-and-icu-mortality-in-medical-patients
#19
COMPARATIVE STUDY
Martin Dres, Peter C Austin, Tài Pham, Philippe Aegerter, Bertrand Guidet, Alexandre Demoule, Antoine Vieillard-Baron, Laurent Brochard, Guillaume Geri
OBJECTIVES: To determine whether ICUs caring for higher volumes of acute respiratory distress syndrome patients would be associated with lower ICU mortality. DESIGN: A 9-year multicenter retrospective cohort study of prospectively collected data. SETTING: French medical ICUs. PATIENTS: From 2004 to 2012, acute respiratory distress syndrome cases were identified from a coding system through a regional database (Collège des Utilisateurs de Données en Réanimation)...
January 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29091088/reentrant-wetting-transition-in-the-spreading-of-cellular-aggregates
#20
Grégory Beaune, Guillaume Duclos, Nada Khalifat, Tomita Vasilica Stirbat, Danijela Matic Vignjevic, Françoise Brochard-Wyart
We study spreading on soft substrates of cellular aggregates using CT26 cells that produce an extracellular matrix (ECM). Compared to our previous work on the spreading of S180 cellular aggregates, which did not secrete ECMs, we found that the spreading velocity of the precursor film is also maximal for intermediate rigidities, but new striking features show up. First, we observed a cascade of liquid-gas-liquid (L/G/L) transitions of the precursor film as the substrate rigidity is decreased. We attribute the L/G transition to a decrease of cell/cell adhesion resulting from the weakening of the cell/substrate adhesion...
November 22, 2017: Soft Matter
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