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Karen E A Burns, Stavroula Raptis, Rosane Nisenbaum, Leena Rizvi, Andrew Jones, Jyoti Bakshi, Wylie Tan, Aleksander Meret, Deborah J Cook, Francois Lellouche, Scott K Epstein, David Gattas, Farhad N Kapadia, Jesús Villar, Laurent Brochard, Martin R Lessard, Maureen O Meade
RATIONALE: Randomized trials and meta-analyses have informed several aspects of weaning. Results are rarely replicated in practice as evidence is applied in intensive care units (ICUs) that differ from the settings in which it was generated. OBJECTIVES: We aimed to (i) describe weaning practice variation (identifying weaning candidates, conducting spontaneous breathing trials (SBTs), using ventilator modes, other aspects of care during weaning); (ii) characterize regional differences in weaning practices; and (iii) identify predictors of common practices...
March 6, 2018: Annals of the American Thoracic Society
A Le Fouler, A Hamy, J Barbieux, V Souday, P Bigot, P Le Naoures, R Jaouen, C Brochard, Aurélien Venara
PURPOSE: For survivors of perineal gangrene (PG), quality of life and functional prognosis of pelvic functions are probably overestimated. The aim of this study was to report long-term anal and urinary sphincter dysfunctions, sexual sequelae, and patients' quality of life after treatment of perineal gangrene. METHODS: This retrospective observational study was conducted in one university hospital over 16 years. Seventy-three patients experienced PG; 22 were subject to long-term follow-up...
March 2, 2018: International Journal of Colorectal Disease
Irene Telias, Laurent Brochard, Ewan C Goligher
No abstract text is available yet for this article.
March 1, 2018: Intensive Care Medicine
Laurent Brochard, Irene Telias
No abstract text is available yet for this article.
March 2018: Critical Care Medicine
Detajin Junhasavasdikul, Irene Telias, Domenico Luca Grieco, Lu Chen, Cinta Millan Gutierrez, Thomas Piraino, Laurent Brochard
Expiratory flow limitation (EFL) is present when the flow cannot rise despite an increase of the expiratory driving pressure. The mechanisms of EFL are debated but are thought to be related to the collapsibility of small airways. In mechanically ventilated patients, EFL can exist during tidal ventilation, representing an extreme situation where lung volume cannot decrease whatever the expiratory driving forces. It is a key factor for the generation of auto- or intrinsic positive end-expiratory pressure (auto-PEEP or PEEPi) and requires specific management such as positioning and adjustment of external PEEP...
February 9, 2018: Chest
Véronique Vitton, Henri Damon, Alban Benezech, Dominique Bouchard, Sarah Brardjanian, Charlène Brochard, Benoit Coffin, Nadia Fathallah, Thierry Higuero, Pauline Jouët, Anne-Marie Leroi, Laure Luciano, Guillaume Meurette, Thierry Piche, Alain Ropert, Jean-Marc Sabate, Laurent Siproudhis
Chronic constipation is a common symptom that regularly affects the quality of life of adult patients. Its treatment is mainly based on dietary rules, laxative drugs, perineal rehabilitation and surgical treatment. The French National Society of Coloproctology offers clinical practice recommendations on the basis of the data in the current literature, including those on recently developed treatments. Most are noninvasive, and the main concepts include the following: stimulant laxatives are now considered safe drugs and can be more easily prescribed as a second-line treatment; biofeedback therapy remains the gold standard for the treatment of anorectal dyssynergia that is resistant to medical treatment; transanal irrigation is the second-line treatment of choice in patients with neurological diseases, but it may also be proposed for patients without neurological diseases; and although interferential therapy may be a new promising treatment, it needs further evaluation...
February 5, 2018: European Journal of Gastroenterology & Hepatology
Matthieu Grégoire, Julia Brochard Libois, Denis Waast, Benjamin Gaborit, Marc Dauty, Guillaume Deslandes, Eric Dailly, Sophie Touchais, David Boutoille, Nicolas Grégoire, William Couet
An obese woman was treated orally by tedizolid 200 mg once daily for a pseudoarthrosis, 10 years after a Roux-en-Y bypass surgery.Total plasma peak concentration was 2.12 mg/L, 3h after intake and AUC0-24h was 28.3 mg/L*h. The AUC0-24h/MIC ratio for unbound concentrations and for sensible Staphylococcus and Streptococcus strains was at least 10.8, higher than a targeted ratio of 3.These results support the use of tedizolid without adjustment after a bariatric surgery.
January 29, 2018: Antimicrobial Agents and Chemotherapy
Daniel Brodie, Vincent Jean-Louis, Laurent J Brochard, Alain Combes, Niall D Ferguson, Carol L Hodgson, John G Laffey, Alain Mercat, Antonio Pesenti, Michael Quintel, Arthur S Slutsky, V Marco Ranieri
No abstract text is available yet for this article.
January 17, 2018: Chest
Irene Telias, Felipe Damiani, Laurent Brochard
No abstract text is available yet for this article.
January 19, 2018: Intensive Care Medicine
Ahmed Mouhli, Habib Ayeb, Tahar Othman, Jérôme Fresnais, Vincent Dupuis, Ian R Nemitz, Joel S Pendery, Charles Rosenblatt, Olivier Sandre, Emmanuelle Lacaze
A long time ago, Brochard and de Gennes predicted the possibility of significantly decreasing the critical magnetic field of the Fredericksz transition (the magnetic Fredericksz threshold) in a mixture of nematic liquid crystals and ferromagnetic particles, the so-called ferronematics. This phenomenon is rarely measured to be large, due to soft homeotropic anchoring induced at the nanoparticle surface. Here we present an optical study of the magnetic Fredericksz transition combined with a light scattering study of the classical nematic liquid crystal: the pentylcyanobiphenyl (5CB), doped with 6 nm diameter magnetic and nonmagnetic nanoparticles...
July 2017: Physical Review. E
Ferran Roche-Campo, Alexandre Bedet, Emmanuel Vivier, Laurent Brochard, Armand Mekontso Dessap
BACKGROUND: Cardiac dysfunction is a common cause of weaning failure. Weaning shares some similarities with a cardiac stress test and may challenge active phases of the cardiac cycle-like ventricular contractility and relaxation. This study aimed at assessing systolic and diastolic function during the weaning process and scrutinizing their dynamics during weaning trials. METHODS: Echocardiography was performed during baseline ventilator settings to assess cardiac function at the initiation of the weaning process and at the start and the end of consecutive weaning trials (performed at day-1, day-2, and before extubation if applicable) to explore the evolution of left ventricle contractility and relaxation in a subset of patients...
January 9, 2018: Annals of Intensive Care
Takeshi Yoshida, Marcelo B P Amato, Domenico Luca Grieco, Lu Chen, Cristhiano A S Lima, Rollin Roldan, Caio C A Morais, Susimeire Gomes, Eduardo L V Costa, Paulo F G Cardoso, Emmanuel Charbonney, Jean-Christophe M Richard, Laurent Brochard, Brian P Kavanagh
RATIONALE: Esophageal manometry is the clinically available method to estimate pleural pressure, thus enabling calculation of the transpulmonary pressure (PL). However, many concerns make uncertain in which lung region esophageal manometry reflects local PL. OBJECTIVES: To determine the accuracy of esophageal pressure (Pes) and in which regions esophageal manometry reflects Ppl and PL; to assess whether lung stress in non-dependent regions can be estimated at end-inspiration from PL...
January 11, 2018: American Journal of Respiratory and Critical Care Medicine
Emmanuel Charbonney, Stéphane Delisle, Dominique Savary, Gilles Bronchti, Marceau Rigollot, Adrien Drouet, Bilal Badat, Paul Ouellet, Patrice Gosselin, Alain Mercat, Laurent Brochard, Jean-Christophe M Richard
BACKGROUND: Studying ventilation and intrathoracic pressure (ITP) induced by chest compressions (CC) during Cardio Pulmonary Resuscitation is challenging and important aspects such as airway closure have been mostly ignored. We hypothesized that Thiel Embalmed Cadavers could constitute an appropriate model. METHODS: We assessed respiratory mechanics and ITP during CC in 11 cadavers, and we compared it to measurements obtained in 9 out-of-hospital cardiac arrest patients and to predicted values from a bench model...
January 6, 2018: Resuscitation
Anthony Chapron, Marc Brochard, Chloé Rousseau, Anne-Charlotte Rousseau, Martine Brujean, Laure Fiquet, Virginie Gandemer
BACKGROUND: Acute fever is the most common pediatric condition encountered in general practice and a source of parental concern that can result in inappropriate behavior. The main objective of this study was to describe and quantify parental reassurance concerning their feverish child in the context of visits to rural general practitioners (GPs). METHOD: The study included the parents of 202 feverish children, aged from 3 months to 6 years, consulting 13 representative rural GPs...
January 9, 2018: BMC Family Practice
Jean-Sébastien Bourseul, Anais Molina, Mael Lintanf, Laetitia Houx, Emmanuelle Chaléat-Valayer, Christelle Pons, Sylvain Brochard
OBJECTIVE: To report current evidence regarding the safety of intramuscular BTI in children with orthopaedic- and neurological-related musculoskeletal disorders under the age of 2 years. DATA SOURCE: PUBMED, The Cochrane Library, and Science Direct, Google Scholar and Web of Science. STUDY SELECTION: Two reviewers independently selected studies based on predetermined inclusion criteria. DATA EXTRACTION: Data relating to the aim were extracted...
December 26, 2017: Archives of Physical Medicine and Rehabilitation
Bhushan Borotikar, Mathieu Lempereur, Mathieu Lelievre, Valérie Burdin, Douraied Ben Salem, Sylvain Brochard
PURPOSE: To report evidence for the concurrent validity and reliability of dynamic MRI techniques to evaluate in vivo joint and muscle mechanics, and to propose recommendations for their use in the assessment of normal and impaired musculoskeletal function. MATERIALS AND METHODS: The search was conducted on articles published in Web of science, PubMed, Scopus, Academic search Premier, and Cochrane Library between 1990 and August 2017. Studies that reported the concurrent validity and/or reliability of dynamic MRI techniques for in vivo evaluation of joint or muscle mechanics were included after assessment by two independent reviewers...
2017: PloS One
Hong-Liang Li, Lu Chen, Laurent Brochard
No abstract text is available yet for this article.
September 2017: Journal of Thoracic Disease
C Guérin, P Beuret, J M Constantin, G Bellani, P Garcia-Olivares, O Roca, J H Meertens, P Azevedo Maia, T Becher, J Peterson, A Larsson, M Gurjar, Z Hajjej, F Kovari, A H Assiri, E Mainas, M S Hasan, D R Morocho-Tutillo, L Baboi, J M Chrétien, G François, L Ayzac, L Chen, L Brochard, A Mercat
INTRODUCTION: While prone positioning (PP) has been shown to improve patient survival in moderate to severe acute respiratory distress syndrome (ARDS) patients, the rate of application of PP in clinical practice still appears low. AIM: This study aimed to determine the prevalence of use of PP in ARDS patients (primary endpoint), the physiological effects of PP, and the reasons for not using it (secondary endpoints). METHODS: The APRONET study was a prospective international 1-day prevalence study performed four times in April, July, and October 2016 and January 2017...
January 2018: Intensive Care Medicine
Elie Azoulay, Jean-Louis Vincent, Derek C Angus, Yaseen M Arabi, Laurent Brochard, Stephen J Brett, Giuseppe Citerio, Deborah J Cook, Jared Randall Curtis, Claudia C Dos Santos, E Wesley Ely, Jesse Hall, Scott D Halpern, Nicholas Hart, Ramona O Hopkins, Theodore J Iwashyna, Samir Jaber, Nicola Latronico, Sangeeta Mehta, Dale M Needham, Judith Nelson, Kathleen Puntillo, Michael Quintel, Kathy Rowan, Gordon Rubenfeld, Greet Van den Berghe, Johannes Van der Hoeven, Hannah Wunsch, Margaret Herridge
In this review, we seek to highlight how critical illness and critical care affect longer-term outcomes, to underline the contribution of ICU delirium to cognitive dysfunction several months after ICU discharge, to give new insights into ICU acquired weakness, to emphasize the importance of value-based healthcare, and to delineate the elements of family-centered care. This consensus of 29 also provides a perspective and a research agenda about post-ICU recovery.
December 5, 2017: Critical Care: the Official Journal of the Critical Care Forum
Mohamad El Zoghbi, Pascale Salameh, Isabelle Stücker, Christophe Paris, Jean Claude Pairon, Antoine Gislard, Jack Siemiatycki, Vincent Bonneterre, Bénédicte Clin, Patrick Brochard, Fleur Delva, Aude Lacourt
OBJECTIVES: The aim of this study was to assess the effect modification of the association between tobacco smoking and phenotypes of lung cancer (histological type, tumor location, and age at diagnosis) by occupational exposure to asbestos or to crystalline silica. MATERIALS AND METHODS: The CaProMat study is a pooled case-only study including 7256 male lung cancer cases recruited between 1996 and 2011 in France and Canada. Two job-exposure matrices (JEMs) were used to assess occupational exposure to asbestos and crystalline silica...
October 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
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