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JOURNAL ARTICLE
Pram Depauw, F van Eijs, C Wensing, R Geuze, H van Santbrink, M Malbrain, J J De Waele
BACKGROUND AND AIMS: Both anaesthesiologists and spine surgeons consider the intra-abdominal pressure (IAP) as an important peri-operative factor affected by patient positioning. We assessed the change in IAP caused by using a thoraco pelvic support (inflatable prone support, IPS) with the subject under general anesthesia. The IAP was measured before, during and immediately after surgery. METHODS: The Spine Intra-Abdominal Pressure study (SIAP trial) is a prospective, single-arm, monocenter, observational study looking at changes in IAP prior, during and after spine surgery...
May 23, 2023: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
#22
RANDOMIZED CONTROLLED TRIAL
Andrew W Kirkpatrick, Federico Coccolini, Matti Tolonen, Samuel Minor, Fausto Catena, Emanuel Gois, Christopher J Doig, Michael D Hill, Luca Ansaloni, Massimo Chiarugi, Dario Tartaglia, Orestis Ioannidis, Michael Sugrue, Elif Colak, S Morad Hameed, Hanna Lampela, Vanni Agnoletti, Jessica L McKee, Naisan Garraway, Massimo Sartelli, Chad G Ball, Neil G Parry, Kelly Voght, Lisa Julien, Jenna Kroeker, Derek J Roberts, Peter Faris, Corina Tiruta, Ernest E Moore, Lee Anne Ammons, Elissavet Anestiadou, Cino Bendinelli, Konstantinos Bouliaris, Rosemarry Carroll, Marco Ceresoli, Francesco Favi, Angela Gurrado, Joao Rezende-Neto, Arda Isik, Camilla Cremonini, Silivia Strambi, Georgios Koukoulis, Mario Testini, Sandy Trpcic, Alessandro Pasculli, Erika Picariello, Fikri Abu-Zidan, Ademola Adeyeye, Goran Augustin, Felipe Alconchel, Yuksel Altinel, Luz Adriana Hernandez Amin, José Manuel Aranda-Narváez, Oussama Baraket, Walter L Biffl, Gian Luca Baiocchi, Luigi Bonavina, Giuseppe Brisinda, Luca Cardinali, Andrea Celotti, Mohamed Chaouch, Maria Chiarello, Gianluca Costa, Nicola de'Angelis, Nicolo De Manzini, Samir Delibegovic, Salomone Di Saverio, Belinda De Simone, Vincent Dubuisson, Pietro Fransvea, Gianluca Garulli, Alessio Giordano, Carlos Gomes, Firdaus Hayati, Jinjian Huang, Aini Fahriza Ibrahim, Tan Jih Huei, Ruhi Fadzlyana Jailani, Mansoor Khan, Alfonso Palmieri Luna, Manu L N G Malbrain, Sanjay Marwah, Paul McBeth, Andrei Mihailescu, Alessia Morello, Francesk Mulita, Valentina Murzi, Ahmad Tarmizi Mohammad, Simran Parmar, Ajay Pak, Michael Pak-Kai Wong, Desire Pantalone, Mauro Podda, Caterina Puccioni, Kemal Rasa, Jianan Ren, Francesco Roscio, Antonio Gonzalez-Sanchez, Gabriele Sganga, Maximilian Scheiterle, Mihail Slavchev, Dmitry Smirnov, Lorenzo Tosi, Anand Trivedi, Jaime Andres Gonzalez Vega, Maciej Waledziak, Sofia Xenaki, Desmond Winter, Xiuwen Wu, Andee Dzulkarnean Zakaria, Zaidi Zakaria
BACKGROUND: Severe complicated intra-abdominal sepsis (SCIAS) has an increasing incidence with mortality rates over 80% in some settings. Mortality typically results from disruption of the gastrointestinal tract, progressive and self-perpetuating bio-mediator generation, systemic inflammation, and multiple organ failure. A further therapeutic option may be open abdomen (OA) management with negative peritoneal pressure therapy (NPPT) to remove inflammatory ascites and attenuate the systemic damage from SCIAS, although there are definite risks of leaving the abdomen open whenever it might possibly be closed...
May 11, 2023: World Journal of Emergency Surgery: WJES
#23
JOURNAL ARTICLE
Kay Choong See, Salar Tayebi, Chew Lai Sum, Jason Phua, Johan Stiens, Robert Wise, Amartya Mukhopadhyay, Manu L N G Malbrain
Increased intra-abdominal pressure (IAP) is an important vital sign in critically ill patients and has a negative impact on morbidity and mortality. This study aimed to validate a novel non-invasive ultrasonographic approach to IAP measurement against the gold standard intra-bladder pressure (IBP) method. We conducted a prospective observational study in an adult medical ICU of a university hospital. IAP measurements using ultrasonography by two independent operators, with different experience levels (experienced, IAPUS1 ; inexperienced, IAPUS2 ), were compared with the gold standard IBP method performed by a third blinded operator...
May 3, 2023: Journal of Clinical Monitoring and Computing
#24
JOURNAL ARTICLE
Erica A Voss, Azza Shoaibi, Lana Yin Hui Lai, Clair Blacketer, Thamir Alshammari, Rupa Makadia, Kevin Haynes, Anthony G Sena, Gowtham Rao, Sebastiaan van Sandijk, Clement Fraboulet, Laurent Boyer, Tanguy Le Carrour, Scott Horban, Daniel R Morales, Jordi Martínez Roldán, Juan Manuel Ramírez-Anguita, Miguel A Mayer, Marcel de Wilde, Luis H John, Talita Duarte-Salles, Elena Roel, Andrea Pistillo, Raivo Kolde, Filip Maljković, Spiros Denaxas, Vaclav Papez, Michael G Kahn, Karthik Natarajan, Christian Reich, Alex Secora, Evan P Minty, Nigam H Shah, Jose D Posada, Maria Teresa Garcia Morales, Diego Bosca, Honorio Cadenas Juanino, Antonio Diaz Holgado, Miguel Pedrera Jiménez, Pablo Serrano Balazote, Noelia García Barrio, Selçuk Şen, Ali Yağız Üresin, Baris Erdogan, Luc Belmans, Geert Byttebier, Manu L N G Malbrain, Daniel J Dedman, Zara Cuccu, Rohit Vashisht, Atul J Butte, Ayan Patel, Lisa Dahm, Cora Han, Fan Bu, Faaizah Arshad, Anna Ostropolets, Fredrik Nyberg, George Hripcsak, Marc A Suchard, Dani Prieto-Alhambra, Peter R Rijnbeek, Martijn J Schuemie, Patrick B Ryan
BACKGROUND: Adverse events of special interest (AESIs) were pre-specified to be monitored for the COVID-19 vaccines. Some AESIs are not only associated with the vaccines, but with COVID-19. Our aim was to characterise the incidence rates of AESIs following SARS-CoV-2 infection in patients and compare these to historical rates in the general population. METHODS: A multi-national cohort study with data from primary care, electronic health records, and insurance claims mapped to a common data model...
April 2023: EClinicalMedicine
#25
JOURNAL ARTICLE
Guy Fishman, Eilon Ram, Dan Gorfil, Yigal Kassif, Rachel David, Tzlil Hershko, Manu L N G Malbrain, Pierre Singer, Daniel I Sessler
OBJECTIVES: Urine output is used to evaluate fluid status and is an important marker for acute kidney injury (AKI). Our primary aim was to validate a new automatic urine output monitoring device by comparison to the current practice - the standard urometer. METHODS: We conducted a prospective observational study in three ICUs. Urine flow measurements by Serenno Medical Automatic urine output measuring device (Serenno Medical, Yokneam, Israel) were compared to standard urometer readings taken automatically at 5-minutes intervals by a camera, and to hourly urometer readings by the nurses, both over 1 to 7 days...
April 7, 2023: Journal of Clinical Monitoring and Computing
#26
JOURNAL ARTICLE
Lawrence Ledoux-Hutchinson, Ron Wald, Manu L N G Malbrain, François Martin Carrier, Sean M Bagshaw, Rinaldo Bellomo, Neill K J Adhikari, Martin Gallagher, Samuel A Silver, Josée Bouchard, Michael J Connor, Edward G Clark, Jean-Maxime Côté, Javier A Neyra, André Denault, William Beaubien-Souligny
BACKGROUND: In critically ill patients receiving KRT, high ultrafiltration rates and persistent fluid accumulation are associated with adverse outcomes. The purpose of this international survey was to evaluate current practices and evidence gaps related to fluid removal with KRT in critically ill patients. METHODS: This was a multinational, web-based survey distributed by seven networks comprising nephrologists and intensivists. Physicians involved in the care of critically ill patients were invited to complete a 39-question survey about fluid management practices on KRT...
June 1, 2023: Clinical Journal of the American Society of Nephrology: CJASN
#27
EDITORIAL
Carmen Andrea Pfortmueller, Wojciech Dabrowski, Manu L N G Malbrain
No abstract text is available yet for this article.
August 2023: Journal of Critical Care
#28
JOURNAL ARTICLE
Lore Huwel, Joke Van Eessen, Jan Gunst, Manu L N G Malbrain, Veerle Bosschem, Tom Vanacker, Sofie Verhaeghe, Dominique D Benoit
AIM: This study examines when healthcare professionals consider intensive care as appropriate care. BACKGROUND: Despite attempts to conceptualize appropriate care in prior research, there is a lack of insight into its meaning and implementation in practice. This is an important issue because healthcare professionals as well as patients and relatives report inappropriate care in the intensive care unit (ICU) on a regular basis. METHODS: A qualitative study was designed, based on principles of grounded theory...
February 2023: Heliyon
#29
JOURNAL ARTICLE
Patrick Brockway, David M Hill, Vanessa Moll, Kelly Stanton, Manu L N G Malbrain, Sai R Velamuri
Objective: A quality improvement study to assess catheter-associated urinary tract infection (CAUTI) rate post-implementation of a bladder catheter with integrated active drain line urine clearance and automated intra-abdominal pressure monitoring in a burn intensive care unit (ICU). DESIGN: Eight-year retrospective before and after study (2015−2022). Setting: A single American Burn Association-verified Burn Center with 14 inpatient beds. Patients: Patients meeting criteria for admission to a Burn Center...
November 22, 2022: Life
#30
JOURNAL ARTICLE
Wojciech Dabrowski, Mariusz Gagos, Dorota Siwicka-Gieroba, Mariusz Piechota, Jan Siwiec, Magdalena Bielacz, Katarzyna Kotfis, Andrzej Stepulak, Luiza Grzycka-Kowalczyk, Andrzej Jaroszynski, Manu Lng Malbrain
BACKGROUND: The systemic inflammatory response following severe COVID-19 is associated with poor outcomes. Several anti-inflammatory medications have been studied in COVID-19 patients. Xanthohumol (Xn), a natural extract from hop cones, possesses strong anti-inflammatory and antioxidative properties. The aim of this study was to analyze the effect of Xn on the inflammatory response and the clinical outcome of COVID-19 patients. METHODS: Adult patients treated for acute respiratory failure (PaO2 /FiO2 less than 150) were studied...
December 9, 2022: Biomedicine & Pharmacotherapy
#31
JOURNAL ARTICLE
Nathane S Felix, Ligia A Maia, Nazareth N Rocha, Gisele C Rodrigues, Mayck Medeiros, Leticia A da Silva, Camila M Baldavira, Sandra de M Fernezlian, Esmeralda M Eher, Vera L Capelozzi, Manu L N G Malbrain, Paolo Pelosi, Patricia R M Rocco, Pedro L Silva
Background: Fluid regimens in acute respiratory distress syndrome (ARDS) are conflicting. The amount of fluid and positive end-expiratory pressure (PEEP) level may interact leading to ventilator-induced lung injury (VILI). We therefore evaluated restrictive and liberal fluid strategies associated with low and high PEEP levels with regard to lung and kidney damage, as well as cardiorespiratory function in endotoxin-induced ARDS. Methods: Thirty male Wistar rats received an intratracheal instillation of Escherichia coli lipopolysaccharide...
2022: Frontiers in Physiology
#32
JOURNAL ARTICLE
Xavier Monnet, Manu L N G Malbrain, Michael R Pinsky
No abstract text is available yet for this article.
January 2023: Intensive Care Medicine
#33
JOURNAL ARTICLE
Fatime Hawchar, Dana Tomescu, Karl Träger, Dominik Joskowiak, Klaus Kogelmann, Jens Soukup, Singrun Friesecke, David Jacob, Jan Gummert, Andreas Faltlhauser, Filippo Aucella, Martijn van Tellingen, Manu L N G Malbrain, Ralph Bogdanski, Günter Weiss, Andreas Herbrich, Stefan Utzolino, Axel Nierhaus, Andreas Baumann, Andreas Hartjes, Dietrich Henzler, Evgeny Grigoryev, Harald Fritz, Friedhelm Bach, Stefan Schröder, Andreas Weyland, Udo Gottschaldt, Matthias Menzel, Olivier Zachariae, Radovan Novak, Jernej Berden, Hendrik Haake, Michael Quintel, Stephan Kloesel, Andreas Kortgen, Stephanie Stecher, Patricia Torti, Frieder Nestler, Markus Nitsch, Detlef Olboeter, Philip Muck, Michael Findeisen, Diane Bitzinger, Jens Kraßler, Martin Benad, Martin Schott, Ulrike Schumacher, Zsolt Molnar, Frank Martin Brunkhorst
The aim of the current paper is to summarize the results of the International CytoSorb Registry. Data were collected on patients of the intensive care unit. The primary endpoint was actual in-hospital mortality compared to the mortality predicted by APACHE II score. The main secondary endpoints were SOFA scores, inflammatory biomarkers and overall evaluation of the general condition. 1434 patients were enrolled. Indications for hemoadsorption were sepsis/septic shock (N = 936); cardiac surgery perioperatively (N = 172); cardiac surgery postoperatively (N = 67) and "other" reasons (N = 259)...
2022: PloS One
#34
REVIEW
Andrea Crosignani, Stefano Spina, Francesco Marrazzo, Stefania Cimbanassi, Manu L N G Malbrain, Niels Van Regenmortel, Roberto Fumagalli, Thomas Langer
Patients with acute pancreatitis (AP) often require ICU admission, especially when signs of multiorgan failure are present, a condition that defines AP as severe. This disease is characterized by a massive pancreatic release of pro-inflammatory cytokines that causes a systemic inflammatory response syndrome and a profound intravascular fluid loss. This leads to a mixed hypovolemic and distributive shock and ultimately to multiorgan failure. Aggressive fluid resuscitation is traditionally considered the mainstay treatment of AP...
October 17, 2022: Annals of Intensive Care
#35
REVIEW
Rita Jacobs, Robert D Wise, Ivan Myatchin, Domien Vanhonacker, Andrea Minini, Michael Mekeirele, Andrew W Kirkpatrick, Bruno M Pereira, Michael Sugrue, Bart De Keulenaer, Zsolt Bodnar, Stefan Acosta, Janeth Ejike, Salar Tayebi, Johan Stiens, Colin Cordemans, Niels Van Regenmortel, Paul W G Elbers, Xavier Monnet, Adrian Wong, Wojciech Dabrowski, Philippe G Jorens, Jan J De Waele, Derek J Roberts, Edward Kimball, Annika Reintam Blaser, Manu L N G Malbrain
BACKGROUND: General pathophysiological mechanisms regarding associations between fluid administration and intra-abdominal hypertension (IAH) are evident, but specific effects of type, amount, and timing of fluids are less clear. OBJECTIVES: This review aims to summarize current knowledge on associations between fluid administration and intra-abdominal pressure (IAP) and fluid management in patients at risk of intra-abdominal hypertension and abdominal compartment syndrome (ACS)...
September 6, 2022: Life
#36
REVIEW
Federico Coccolini, Francesco Corradi, Massimo Sartelli, Raul Coimbra, Igor A Kryvoruchko, Ari Leppaniemi, Krstina Doklestic, Elena Bignami, Giandomenico Biancofiore, Miklosh Bala, Ceresoli Marco, Dimitris Damaskos, Walt L Biffl, Paola Fugazzola, Domenico Santonastaso, Vanni Agnoletti, Catia Sbarbaro, Mirco Nacoti, Timothy C Hardcastle, Diego Mariani, Belinda De Simone, Matti Tolonen, Chad Ball, Mauro Podda, Isidoro Di Carlo, Salomone Di Saverio, Pradeep Navsaria, Luigi Bonavina, Fikri Abu-Zidan, Kjetil Soreide, Gustavo P Fraga, Vanessa Henriques Carvalho, Sergio Faria Batista, Andreas Hecker, Alessandro Cucchetti, Giorgio Ercolani, Dario Tartaglia, Joseph M Galante, Imtiaz Wani, Hayato Kurihara, Edward Tan, Andrey Litvin, Rita Maria Melotti, Gabriele Sganga, Tamara Zoro, Alessandro Isirdi, Nicola De'Angelis, Dieter G Weber, Adrien M Hodonou, Richard tenBroek, Dario Parini, Jim Khan, Giovanni Sbrana, Carlo Coniglio, Antonino Giarratano, Angelo Gratarola, Claudia Zaghi, Oreste Romeo, Michael Kelly, Francesco Forfori, Massimo Chiarugi, Ernest E Moore, Fausto Catena, Manu L N G Malbrain
BACKGROUND: Non-traumatic emergency general surgery involves a heterogeneous population that may present with several underlying diseases. Timeous emergency surgical treatment should be supplemented with high-quality perioperative care, ideally performed by multidisciplinary teams trained to identify and handle complex postoperative courses. Uncontrolled or poorly controlled acute postoperative pain may result in significant complications. While pain management after elective surgery has been standardized in perioperative pathways, the traditional perioperative treatment of patients undergoing emergency surgery is often a haphazard practice...
September 21, 2022: World Journal of Emergency Surgery: WJES
#37
JOURNAL ARTICLE
Salar Tayebi, Robert Wise, Ali Pourkazemi, Johan Stiens, Manu L N G Malbrain
Introduction: Increased intra-abdominal pressure (IAP) has an important impact on morbidity and mortality in critically ill patients. The SERENNO Sentinel system (Serenno Medical, Yokne'am Illit, Israel) is a novel device that allows automatic and continuous IAP measurements. Aims: Pre-clinical validation in a bench model study comparing the new device with the gold standard method and two other continuous IAP measurement devices. Methods: IAP measurement with the novel SERENNO device (IAPSER ) was compared with the gold standard IAPH2O (water column height) and two other automatic and continuous IAP measurement devices: IAPCiM measured via the CiMON device (Pulsion Medical Systems, Munich, Germany) and IAPSPIE measured using the Spiegelberg device (Spiegelberg, Hamburg, Germany), which previously received the CE mark for clinical applications...
July 30, 2022: Life
#38
JOURNAL ARTICLE
Manu L N G Malbrain, Greg Martin, Marlies Ostermann
No abstract text is available yet for this article.
December 2022: Intensive Care Medicine
#39
EDITORIAL
Manu L N G Malbrain, Bart L De Keulenaer, Ashish K Khanna
No abstract text is available yet for this article.
August 4, 2022: Intensive Care Medicine
#40
JOURNAL ARTICLE
Prashant Nasa, Robert Wise, Paul W G Elbers, Adrian Wong, Wojciech Dabrowski, Niels V Regenmortel, Xavier Monnet, Sheila N Myatra, Manu L N G Malbrain
PURPOSE: In the absence of recent international recommendations supported by scientific societies like Anesthesiology or Intensive Care Medicine, healthcare professionals (HCP) knowledge on IV fluid is expected to vary. We undertook a cross-sectional survey, aiming to assess prescription patterns and test the knowledge of HCP for IV fluid use in the operating room (OR) and intensive care unit (ICU). METHODS: An online international cross-sectional survey was conducted between October 20, 2019, and November 27, 2021...
October 2022: Journal of Critical Care
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