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https://www.readbyqxmd.com/read/28770536/preparation-and-in-vivo-evaluation-of-lecithin-based-microparticles-for-topical-delivery-of-minoxidil
#1
Hyo-Jung Lee, Dong-Won Oh, Min-Ju Na, Dong-Wook Kim, Dong-Yeon Yuk, Hyoung-Chul Choi, Yong-Beom Lee, Kun Han, Chun-Woong Park
Minoxidil is widely used for treatment of androgenic alopecia. Commercial products containing minoxidil are usually in solution form. Repeated applications of minoxidil solution can lead to adverse effects such as skin irritation and horniness. The aims of this study were to prepare lecithin-based microparticle in minoxidil solution for enhancement of minoxidil topical delivery and skin protection and evaluate the ability of lecithin on in vitro delivery, in vivo hair growth, and skin trouble improvement compared to commercial minoxidil solution...
August 2, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28761264/a-case-report-of-verruca-vulgaris-on-basis-of-alopecia-areata-successfully-treated-with-diphenylcyclopropenone
#2
Tugba Kevser Uzuncakmak, Mahmut Can Koska, Ayşe Serap Karadağ, Necmettin Akdeniz
Alopecia areata is an autoimmune skin disease which is usually characterized by patchy hair loss in effected regions. Diagnosis usually based on clinical findings and main treatment options include topical, intralesional, systemic corticosteroids, and topical immunotherapy. Verruca vulgaris is an infectious disease caused by human papillomavirus which is usually characterized by well-marginated hyperkeratotic papules or plaques. There are several treatment modalities such as physical and chemical destruction and topical immunotherapy...
January 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28761259/a-comparative-study-of-microneedling-with-platelet-rich-plasma-plus-topical-minoxidil-5-and-topical-minoxidil-5-alone-in-androgenetic-alopecia
#3
Kaksha B Shah, Aarti N Shah, Rekha B Solanki, Ranjan C Raval
CONTEXT: There are very few studies evaluating efficacy of platelet-rich plasma (PRP) in hair restoration and its combination with microneedling. As far as ascertained, there is no study to evaluate efficacy of microneedling with PRP plus topical minoxidil (5%) versus topical minoxidil (5%) alone in androgenetic alopecia (AGA). AIMS: This study aims (1) to compare the efficacy of (a) topical minoxidil (5%) alone and (b) topical minoxidil (5%) + microneedling with PRP in men between 18 and 50 years with AGA Grade III to V vertex (Norwood-Hamilton scale) and (2) to perform objective and subjective evaluation based on clinical improvement and photographic evidence...
January 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28748570/lichen-planopilaris-in-a-latin-american-chilean-population-demographics-clinical-profile-and-treatment-experience
#4
F Mardones, J Shapiro
BACKGROUND: Lichen planopilaris (LPP) is characterized by lymphocytic infiltrate, fibrosis and potential destruction of the hair follicle. Demographic and clinical studies in LPP are limited, and racial differences have not been thoroughly investigated. AIM: To analyse epidemiological data and clinical profiles of Chilean adults with LPP, and report on the treatments used. METHODS: This was a retrospective review of medical records and clinical follow-up of Chilean adults with a clinical and histopathological diagnosis of LPP...
July 27, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28697221/hair-loss-myths
#5
Gabriella DiMarco, Amy McMichael
<p>INTRODUCTION: Hair loss is a common complaint seen in dermatology clinics. From frustration and attempts at self-help, patients with hair loss may present to the dermatologist with false beliefs, or myths, about the causes of their condition and what treatments are effective.</p> <p>METHODS: We identified 12 common myths about hair loss, categorized as myths about minoxidil treatment, vitamin and mineral supplements, natural topical treatments, and hair care practices. We performed a PubMed search to find evidence to support or refute each myth...
July 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28616431/comparing-the-effects-of-zinc-sulfate-calcium-pantothenate-their-combination-and-minoxidil-solution-regimens-on-controlling-hair-loss-in-women-a-randomized-controlled-trial
#6
Mansour Siavash, Fereshteh Tavakoli, Fatemeh Mokhtari
OBJECTIVE: This study was conducted to evaluate the combination of oral supplements with 2% minoxidil solution in four groups of women with hair loss. METHODS: A prospective, randomized controlled trial was conducted from July to December 2016 in dermatology clinics affiliated to Isfahan University of Medical Sciences. A total of 73, 15-45-year-old, women with hair loss participated in this 4-month study. Simple randomization using Random Allocation Software was done to put the participants in four groups to receive coadministration of zinc sulfate and calcium pantothenate, zinc sulfate, calcium pantothenate, and 2% minoxidil solution...
April 2017: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/28604133/a-preliminary-study-on-topical-cetirizine-in-the-therapeutic-management-of-androgenetic-alopecia
#7
A Rossi, D Campo, M C Fortuna, V Garelli, G Pranteda, D Di Nunno, M Carlesimo
Androgenetic alopecia (AGA) is a common form of scalp hair loss that affects up to 50% of males between 18-40 years old. Several molecules are commonly used for the treatment of AGA, acting on different steps of its pathogenesis (Minoxidil, Finasteride, Serenoa repens) and show some side effects. In literature, on the basis of hypertrichosis observed in patients treated with analogues of prostaglandin PGF2α, was supposed that prostaglandins would have an important role in the hair growth: PGE and PGF2α play a positive role, while PGD2 a negative one...
June 12, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28594262/an-analysis-of-gene-expression-data-involving-examination-of-signaling-pathways-activation-reveals-new-insights-into-the-mechanism-of-action-of-minoxidil-topical-foam-in-men-with-androgenetic-alopecia
#8
Georgios N Stamatas, Jeff Wu, Apostolos Pappas, Paradi Mirmirani, Thomas S McCormick, Kevin D Cooper, Mary Consolo, Jane Schastnaya, Ivan Ozerov, Alexander Aliper, Alex Zhavoronkov
Androgenetic alopecia is the most common form of hair loss. Minoxidil has been approved for the treatment of hair loss, however its mechanism of action is still not fully clarified. In this study, we aimed to elucidate the effects of 5% minoxidil topical foam on gene expression and activation of signaling pathways in vertex and frontal scalp of men with androgenetic alopecia. We identified regional variations in gene expression and perturbed signaling pathways using in silico Pathway Activation Network Decomposition Analysis (iPANDA) before and after treatment with minoxidil...
June 8, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28593214/association-between-gender-and-drug-cost-for-over-the-counter-minoxidil
#9
Mackenzie R Wehner, Kevin T Nead, Jules B Lipoff
No abstract text is available yet for this article.
August 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28566902/therapeutic-efficacy-of-a-combination-therapy-of-topical-17%C3%AE-estradiol-and-topical-minoxidil-on-female-pattern-hair-loss-a-noncomparative-retrospective-evaluation
#10
Sung Jay Choe, Solam Lee, Jaewoong Choi, Won-Soo Lee
BACKGROUND: A variety of agents have been used to treat female pattern hair loss (FPHL), including topical minoxidil, topical 17α-estradiol, oral anti-androgen agents, and mineral supplements. Compared with these single agent regimens, combination therapies could be a better therapeutic option in expectation of superior treatment outcome. OBJECTIVE: This study was designed to determine the efficacy of a combination therapy consisting of topical 0.025% 17α-estradiol and 3% minoxidil in Korean patients with FPHL...
June 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28562433/platelet-rich-plasma-in-combination-with-5-minoxidil-topical-solution-and-1-mg-oral-finasteride-for-the-treatment-of-androgenetic-alopecia-a-randomized-placebo-controlled-double-blind-half-head-study
#11
Rubina Alves, Ramon Grimalt
No abstract text is available yet for this article.
May 25, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28557785/updated-stability-data-for-midazolam-oseltamivir-phosphate-and-propranolol-hydrochloride-in-surspend-sf-and-minoxidil-in-espumil
#12
Eli Dijkers, Valerie Nanhekhan, Astrid Thorissen
No abstract text is available yet for this article.
May 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28539964/preclinical-and-clinical-studies-demonstrate-that-the-proprietary-herbal-extract-da-5512-effectively-stimulates-hair-growth-and-promotes-hair-health
#13
Jae Young Yu, Biki Gupta, Hyoung Geun Park, Miwon Son, Joon-Ho Jun, Chul Soon Yong, Jeong Ah Kim, Jong Oh Kim
The proprietary DA-5512 formulation comprises six herbal extracts from traditional oriental plants historically associated with therapeutic and other applications related to hair. Here, we investigated the effects of DA-5512 on the proliferation of human dermal papilla cells (hDPCs) in vitro and on hair growth in C57BL/6 mice and conducted a clinical study to evaluate the efficacy and safety of DA-5512. DA-5512 significantly enhanced the viability of hDPCs in a dose-dependent manner (p < 0.05), and 100 ppm of DA-5512 and 1 μM minoxidil (MXD) significantly increased the number of Ki-67-positive cells, compared with the control group (p < 0...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28521549/efficacy-of-topical-latanoprost-versus-minoxidil-and-betamethasone-valerate-on-the-treatment-of-alopecia-areata
#14
Amal Ahmad El-Ashmawy, Iman Hamed El-Maadawy, Gamal Mohamed El-Maghraby
BACKGROUND: Alopecia areata (AA) is one of the most common causes of localized hair loss. There is no universally proven therapy that induces and sustains remission of hair growth in AA. OBJECTIVE: To compare the efficacy and safety of topical latanoprost, minoxidil and betamethasone valerate on hair growth in patients with AA. PATIENTS AND METHODS: Hundred patients with AA classified into five groups of 20 treated with: Group I, latanoprost 0...
June 15, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28489273/low-level-light-minoxidil-5-combination-versus-either-therapeutic-modality-alone-in-management-of-female-patterned-hair-loss-a-randomized-controlled-study
#15
Samia M Esmat, Rehab A Hegazy, Heba I Gawdat, Rania M Abdel Hay, Riham S Allam, Rofaida El Naggar, Hoda Moneib
BACKGROUND: Female pattern hair loss (FPHL) is the most common form of hair loss in women. Nevertheless, its management represents a real challenge. Among the FDA approved therapeutic modalities for FPHL are topical minoxidil and more recently low-level light therapy (LLLT). AIM OF WORK: Assess the efficacy and safety of LLLT in comparison to topical minoxidil 5% and to a combination of both therapies in the treatment of FPHL. PATIENTS AND METHODS: This study included 45 female patients with proven FPHL...
May 10, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28450835/bioactives-in-chinese-proprietary-medicine-modulates-5%C3%AE-reductase-activity-and-gene-expression-associated-with-androgenetic-alopecia
#16
Justin J Y Tan, Jing Pan, Lihan Sun, Junying Zhang, Chunyong Wu, Lifeng Kang
Androgenetic alopecia (AGA) is characterized by a progressive and patterned transformation of thick, pigmented terminal scalp hairs into short, hypo-pigmented vellus-like hairs. The use of Minoxidil and Finasteride to treat AGA are often associated with complications in safety and efficacy. However, herbal remedies are deemed to have lesser side effects in many societies. This study aims to identify potential hair growth properties of individual compounds from a Chinese proprietary medicine known as Yangxue Shengfa capsule (YSC), used in China for many years for improving AGA...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28436015/the-use-of-topical-minoxidil-to-accelerate-nail-growth-a-pilot-study
#17
Kumpol Aiempanakit, Alan Geater, Preeyachat Limtong, Kathleen Nicoletti
Linear nail growth rate is affected by various conditions, one of which is the level of blood flow. Our supposition was that topical minoxidil, which has vasodilatory properties, can increase the rate of nail growth. The aim of this study was to determine the impact of topical minoxidil on nail growth. A 5% topical minoxidil solution was applied twice daily to the fingernails of 32 participants. Two groups of 16 participants were randomly chosen. In one group, the applications were made to the right index and left ring fingernails, and, in the other, the left index and right ring fingernails...
April 23, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28405563/minoxidil-induced-hypertrichosis-in-a-child-with-alopecia-areata
#18
Ajay Kumar Rai
No abstract text is available yet for this article.
March 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28403264/a-retrospective-review-of-treatment-results-for-patients-with-central-centrifugal-cicatrical-alopecia
#19
Ariana Eginli, Emily Dothard, Courtney W Bagayoko, Karen Huang, Alyssa Daniel, Amy J McMichael
<p>INTRODUCTION: Central centrifugal cicatricial alopecia (CCCA) is a form of scarring alopecia primarily affecting women of African descent on the crown of the scalp. Limited data exists regarding evidence-based treatment for CCCA.</p> <p>OBJECTIVE: To examine photos of subjects with CCCA before and after treatment in order to evaluate results of treatment and compare results of different treatment regimens.</p> <p>METHODS: Photographs of 15 subjects with CCCA before and after treatment were evaluated by two blinded investigators who assigned disease severity scores to photographs based on a published scale: Central Scalp Alopecia Photographic Scale in African American Women...
April 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28396101/the-effectiveness-of-treatments-for-androgenetic-alopecia-a-systematic-review-and-meta-analysis
#20
REVIEW
Areej Adil, Marshall Godwin
BACKGROUND: Androgenetic alopecia, or male pattern hair loss, is a hair loss disorder mediated by dihydrotestosterone, the potent form of testosterone. Currently, minoxidil and finasteride are Food and Drug Administration (FDA)-approved, and HairMax LaserComb, which is FDA-cleared, are the only treatments recognized by the FDA as treatments of androgenetic alopecia. OBJECTIVE: This systematic review and meta-analysis assesses the efficacy of nonsurgical treatments of androgenetic alopecia in comparison to placebo for improving hair density, thickness, growth (defined by an increased anagen:telogen ratio), or subjective global assessments done by patients and investigators...
July 2017: Journal of the American Academy of Dermatology
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