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https://www.readbyqxmd.com/read/27908779/lipoprotein-lipase-does-not-increase-significantly-in-the-postprandial-plasma
#1
Nobuyoshi Ishiyama, Kouji Sakamaki, Younosuke Shimomura, Kazuhiko Kotani, Kokoro Tsuzaki, Naoki Sakane, Kazuya Miyashita, Isao Fukamachi, Junji Kobayashi, Kimber L Stanhope, Peter J Havel, Keiko Kamachi, Akira Tanaka, Yoshiharu Tokita, Tetsuo Machida, Masami Murakami, Katsuyuki Nakajima
BACKGROUND: Previous reports have shown that lipoprotein lipase (LPL) activity significantly increases in the postprandial plasma associated with the increase of TG-rich lipoproteins. Therefore, we have reexamined those relationships using newly developed LPL assay with the different kinds of food intake. METHODS: Standard meal (n=81), 50g of fat (n=54), 75g of glucose (n=25) and cookie (25g fat and 75g carbohydrate fat) (n=28) were administered in generally healthy volunteers...
November 28, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27898284/increased-vldl-tg-fatty-acid-storage-in-skeletal-muscle-in-men-with-type-2-diabetes
#2
Iben R Andersen, Esben Søndergaard, Lars P Sørensen, Birgitte Nellemann, Lars C Gormsen, Michael D Jensen, Søren Nielsen
CONTEXT: Lipoprotein lipase (LPL) activity is considered the rate-limiting step of very-low-density-lipoprotein triglycerides (VLDL-TG) tissue storage, and has been suggested to relate to the development of obesity as well as insulin resistance and type 2 diabetes. OBJECTIVE: The objective of the study was to assess the relationship between the quantitative storage of VLDL-TG fatty acids and LPL activity and other storage factors in muscle and adipose tissue. In addition, we examine whether such relations were influenced by type 2 diabetes...
November 29, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27891367/comparison-of-mustard-oil-and-ghee-consumption-on-the-history-of-coronary-heart-disease-in-urban-population-of-india
#3
Soumen Manna, Hanjabam Barun Sharma, Soniya Vyas, Jayant Kumar
INTRODUCTION: Coronary Heart Disease (CHD) is one of the leading causes of mortality in India, due to high consumption of mustard oil and ghee among urban population. AIM: To find out the relationship of mustard oil and ghee consumption on CHD history. MATERIALS AND METHODS: By a random cross-sectional, house-to-house survey in North India, 137 people aged between 40-80 years (70 males and 67 females) were selected by dietary history of Mustard Oil (MO) and Ghee consumption (G), but having no other CHD precipitating factor...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27871790/antioxidant-and-anti-hyperlipidemic-effects-of-mycelia-zinc-polysaccharides-by-pleurotus-eryngii-var-tuoliensis
#4
Nuo Xu, Zhenzhen Ren, Jianjun Zhang, Xinling Song, Zheng Gao, Huijuan Jing, Shangshang Li, Shouxian Wang, Le Jia
The aims of this work were designed to investigate the hepatoprotective and antioxidant effects of acidic- and alkali-extractable mycelia zinc polysaccharides (AcMZPS, AlMZPS) from Pleurotus eryngii var. tuoliensis on high-fat-high-cholesterol emulsion-induced hyperlipidemic mice. The in vivo experiments demonstrated that both AcMZPS and AlMZPS had potential hepatoprotective effects by significantly decreasing the levels of LDL-C, VLDL-C, TC, TG, ALT, AST, ALP, MDA and LPO, and remarkably increasing the HDL-C, SOD, GSH-Px, and CAT in serum lipid/liver homogenate, respectively...
November 18, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27869741/isoliquiritigenin-attenuates-atherogenesis-in-apolipoprotein-e-deficient-mice
#5
Fen Du, Quzhen Gesang, Jia Cao, Mei Qian, Li Ma, Dongfang Wu, Hong Yu
Isoliquiritigenin (ISL) exhibits antioxidation and anti-inflammation activity. We sought to investigate the effects and mechanism of ISL on the development of atherosclerotic lesions in apolipoprotein E-deficient (apoE(-/-)) mice. Firstly, we determined that ISL reduced the mRNA levels of inflammatory factors interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), and monocyte chemotactic protein-1 (MCP-1), while it increased the expression of several lipoprotein-related genes in peritoneal macrophages treated with lipopolysaccharide (LPS)...
November 18, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27867278/effect-of-methanolic-leaf-extract-of-talinum-triangulare-jacq-willd-on-biochemical-parameters-in-diet-induced-dyslipidemia-wistar-rats
#6
Olubukola Sinbad Olorunnisola, Adewale Adetutu, Anthony Jide Afolayan, Abiodun Olusoji Owoade
OBJECTIVE: To investigate the effect of methanolic leaf extract of Talinum triangulare on hematological parameters, enzymatic and non-enzymatic antioxidant status, and serum lipid in Wistar rats fed standard laboratory, or 2% cholesterol-enrich diet. MATERIAL AND METHODS: Wistar rats (180-210g) divided into six groups of six animals (males) each were fed 2% cholesterol-enriched diet and orally treated with 0.9% saline or extract of Talinum triangulare (250, 500, and 1000 mg/kg per body weight) daily for eight weeks...
October 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27862118/prevention-of-hepatic-fibrosis-with-liver-microsomal-triglyceride-transfer-protein-deletion-in-liver-fatty-acid-binding-protein-null-mice
#7
Elizabeth P Newberry, Yan Xie, Susan M Kennedy, Mark J Graham, Rosanne M Crooke, Hui Jiang, Anping Chen, Daniel S Ory, Nicholas O Davidson
: Blocking hepatic very low density lipoprotein (VLDL) secretion via genetic or pharmacologic inhibition of microsomal triglyceride (TG) transfer protein (Mttp) causes hepatic steatosis, yet the risks for developing hepatic fibrosis are poorly understood. Here we report that liver-specific Mttp knockout mice (Mttp-LKO) exhibit both steatosis and fibrosis, which is exacerbated by a high trans fat, fructose diet. When crossed into germline Liver fatty acid binding protein null mice (Mttp-LKO, L-Fabp (-/-) , ie DKO mice) hepatic steatosis was greatly diminished and fibrosis prevented, on both low and high fat diets...
November 14, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27829582/postprandial-hyperlipidemia-and-remnant-lipoproteins
#8
Daisaku Masuda, Shizuya Yamashita
Fasting hypertriglyceridemia is positively associated with the morbidity of coronary heart disease (CHD), and postprandial (non-fasting) hypertriglyceridemia is also correlated with the risk status for CHD, which is related to the increase in chylomicron (CM) remnant lipoproteins produced from the intestine. CM remnant particles, as well as oxidized low density lipoprotein (LDL) or very low density lipoprotein (VLDL) remnants, are highly atherogenic and act by enhancing systemic inflammation, platelet activation, coagulation, thrombus formation, and macrophage foam cell formation...
November 8, 2016: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/27816804/persistent-changes-in-lipoprotein-lipids-after-a-single-infusion-of-ascending-doses-of-mdco-216-apoa-imilano-popc-in-healthy-volunteers-and-stable-coronary-artery-disease-patients
#9
Herman J Kempen, Monica Gomaraschi, Sara Simonelli, Laura Calabresi, Matthijs Moerland, James Otvos, Elias Jeyarajah, David Kallend, Peter L J Wijngaard
BACKGROUND AND AIMS: Effects of single ascending doses of MDCO-216 on plasma lipid and lipoprotein levels were assessed in human healthy volunteers and in patients with stable coronary artery disease (CAD). METHODS: MDCO-216 was infused at a single dose of 5, 10, 20, 30 or 40 mg/kg over 2 h and blood was collected at 2, 4, 8, 24, 48, 168 and 720 h after start of infusion (ASOI). Lipoprotein lipids were assessed by FLPC and by 1H NMR. RESULTS: Plasma concentrations of free cholesterol (FC) displayed a rapid and dose-dependent rise, peaking at 8 h, but remaining above baseline until 48 h ASOI, whereas levels of esterified cholesterol (CE) increased at lower doses but not at higher doses, and even decreased below baseline at the highest dose...
October 24, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27811230/in-vivo-activation-of-leukocyte-gpr120-ffar4-by-polyunsaturated-fatty-acids-has-minimal-impact-on-atherosclerosis-in-ldl-receptor-knockout-mice
#10
Swapnil V Shewale, Amanda L Brown, Xin Bi, Elena Boudyguina, Janet K Sawyer, Martha A Alexander-Miller, John S Parks
G protein-coupled receptor 120 (GPR120/FFAR4) activation by n-3 PUFAs attenuates inflammation, but its impact on atherosclerosis is unknown. We determined whether in vivo activation of leukocyte GPR120/FFAR4 by n-3 vs. n-6 PUFA is atheroprotective. Leukocyte GPR120/FFAR4 WT or KO mice in the LDL receptor KO background were generated by bone marrow transplantation. Mice were fed one of the four atherogenic diets containing 0.2% cholesterol and 10% calories as palm oil (PO) + 10% calories as: 1) PO, 2) fish oil (FO; 20:5 n-3 and 22:6 n-3 enriched), 3) echium oil (EO; 18:4 n-3 enriched), or 4) borage oil (BO; 18:3 n-6 enriched) for 16 weeks...
November 3, 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/27790463/comparison-between-the-effect-of-cow-ghee-and-butter-on-memory-and-lipid-profile-of-wistar-rats
#11
Yogita Surendra Karandikar, Akshata Sanjay Bansude, Eesha Ajit Angadi
INTRODUCTION: The traditional texts designate Cow Ghee as Medhya Rasayana, beneficial for mental alertness and memory. There has been concern about increased risk of cardiovascular disease due to its high percentage of saturated fatty acids in ghee. Amongst all edible fats, nutrition composition of cow ghee and butter is comparatively similar. Hence we had planned a study to assess effect of cow ghee on memory and lipid profile. AIM: So the aim of this study is to assess the effect of cow ghee on memory and lipid profile...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27761069/influence-of-extracting-solvent-on-pharmacological-activity-and-cytotoxicity-of-polygonum-minus-a-commonly-consumed-herb-in-southeast-asia
#12
Parayil Varghese Christapher, Subramani Parasuraman, Palanimuthu Vasanth Raj, Sultan Ayesh Mohammed Saghir, Mohd Zaini Asmawi, Murugaiyah Vikneswaran
OBJECTIVE: To investigate the antihyperlipidemic, antioxidant, and cytotoxic effect of aqueous and methanol extract of leaves of Polygonum minus. MATERIALS AND METHODS: Acute antihyperlipidemic effect was studied on chemically induced hyperlipidemic rat model. Treated groups received aqueous and methanol extract of leaves of P. minus respectively (1000 mg/kg; oral) whereas standard treated group received atorvastatin (60 mg/kg; oral) for 3 consecutive days. Blood samples were collected at fixed intervals for lipid profile analysis...
July 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27741216/effect-of-resistance-training-and-caloric-restriction-on-the-metabolic-syndrome
#13
Eve Normandin, Elizabeth Chmelo, Mary F Lyles, Anthony P Marsh, Barbara J Nicklas
PURPOSE: The prevalence of metabolic syndrome is greatest in older obese adults and effective evidence-based treatment strategies are lacking. This study determined the efficacy of adding caloric restriction (CR) for weight loss to resistance training (RT) on metabolic syndrome (MetS) and its individual components in older overweight and obese adults. METHODS: We performed a 5-month randomized controlled trial in 126 older (65-79 yrs) overweight and obese (Body Mass Index: 27-35 kg/m) men and women who were assigned to progressive 3-d/wk, moderate-intensity RT with (RT+CR) or without caloric restriction (RT)...
October 13, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27736980/patients-with-rheumatoid-arthritis-show-altered-lipoprotein-profiles-with-dysfunctional-high-density-lipoproteins-that-can-exacerbate-inflammatory-and-atherogenic-process
#14
Jae-Yong Kim, Eun-Young Lee, Jin Kyun Park, Yeong Wook Song, Jae-Ryong Kim, Kyung-Hyun Cho
OBJECTIVE: In order to identify putative biomarkers in lipoprotein, we compared lipid and lipoprotein properties between rheumatoid arthritis (RA) patients and control with similar age. METHODS: We analyzed four classes of lipoproteins (VLDL, LDL, HDL2, HDL3) from both male (n = 8, 69±4 year-old) and female (n = 25, 53±7 year-old) rheumatoid arthritis (RA) patients as well as controls with similar age (n = 13). RESULTS: Although RA group showed normal levels of total cholesterol (TC), low-density lipoprotein (LDL)-cholesterol, and glucose, however, the RA group showed significantly reduced high-density lipoprotein (HDL)-C level and ratio of HDL-C/TC...
2016: PloS One
https://www.readbyqxmd.com/read/27731821/rauwolfia-serpentina-improves-altered-glucose-and-lipid-homeostasis-in-fructose-induced-type-2-diabetic-mice
#15
Muhammad Bilal Azmi, Shamim A Qureshi
Rauwolfia serpentina is well-reported in traditional medicines for the treatment of hypertensive and neurological disorders. However, its antidiabetic potential has been currently described in both alloxan-treated and normoglycemic mice. Present effort was carried out to investigate the effect of methanol root extract (MREt) of R.serpentina in fructose-induced type 2 diabetic mice. Experimental mice were grouped into normal control (distilled water 1ml/kg) and fructose-induced type 2 diabetic groups (10% fructose 1 ml/kg)...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27692001/acetoacetic-acid-induces-oxidative-stress-to-inhibit-the-assembly-of-very-low-density-lipoprotein-in-bovine-hepatocytes
#16
Xiaoxia Shi, Dangdang Li, Qinghua Deng, Zhicheng Peng, Chenxu Zhao, Xiaobing Li, Zhe Wang, Xinwei Li, Guowen Liu
Dairy cows with fatty liver or ketosis exhibit hyperketonemia, oxidative stress, and a low rate of very low density lipoprotein (VLDL) assembly, and there may be a potential link among these characteristics. Therefore, the objective of this study was to determine the effect of acetoacetic acid (AcAc) on the assembly of VLDL in cow hepatocytes. Cultured cow hepatocytes were treated with different concentrations of AcAc with or without N-acetylcysteine (NAC, an antioxidant). AcAc treatment decreased the mRNA expression and activities of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), and significantly increased malondialdehyde (MDA) content, indicative of oxidative stress...
October 3, 2016: Journal of Dairy Research
https://www.readbyqxmd.com/read/27690087/a-trypsin-inhibitor-from-tamarind-reduces-food-intake-and-improves-inflammatory-status-in-rats-with-metabolic-syndrome-regardless-of-weight-loss
#17
Fabiana M C Carvalho, Vanessa C O Lima, Izael S Costa, Amanda F Medeiros, Alexandre C Serquiz, Maíra C J S Lima, Raphael P Serquiz, Bruna L L Maciel, Adriana F Uchôa, Elizeu A Santos, Ana H A Morais
Trypsin inhibitors are studied in a variety of models for their anti-obesity and anti-inflammatory bioactive properties. Our group has previously demonstrated the satietogenic effect of tamarind seed trypsin inhibitors (TTI) in eutrophic mouse models and anti-inflammatory effects of other trypsin inhibitors. In this study, we evaluated TTI effect upon satiety, biochemical and inflammatory parameters in an experimental model of metabolic syndrome (MetS). Three groups of n = 5 male Wistar rats with obesity-based MetS received for 10 days one of the following: (1) Cafeteria diet; (2) Cafeteria diet + TTI (25 mg/kg); and (3) Standard diet...
2016: Nutrients
https://www.readbyqxmd.com/read/27632909/twice-weekly-intake-of-farmed-atlantic-salmon-salmo-salar-positively-influences-lipoprotein-concentration-and-particle-size-in-overweight-men-and-women
#18
Susan K Raatz, LuAnn K Johnson, Thad A Rosenberger, Matthew J Picklo
The US Dietary Guidelines for Americans recommend twice weekly fish intake. Farmed Atlantic salmon is a good source of omega-3 (n-3) fatty acids which have positive lipid modifying effects; however, it is unknown whether these responses are dose-dependent. Our primary research objective was to determine the effect of dose-dependent intake of farmed Atlantic salmon on lipoprotein particle (P) size and concentration. We hypothesized that low-density lipoprotein (LDL)-P and high-density lipoprotein (HDL)-P size and concentration would increase with salmon intake in a dose-dependent manner...
September 2016: Nutrition Research
https://www.readbyqxmd.com/read/27599291/inhibition-of-apolipoprotein-b-synthesis-stimulates-endoplasmic-reticulum-autophagy-that-prevents-steatosis
#19
Donna M Conlon, Tiffany Thomas, Tatyana Fedotova, Antonio Hernandez-Ono, Gilbert Di Paolo, Robin B Chan, Kelly Ruggles, Sarah Gibeley, Jing Liu, Henry N Ginsberg
Inhibition of VLDL secretion reduces plasma levels of atherogenic apolipoprotein B (apoB) lipoproteins but can also cause hepatic steatosis. Approaches targeting apoB synthesis, which lies upstream of VLDL secretion, have potential to effectively reduce dyslipidemia but can also lead to hepatic accumulation of unsecreted triglycerides (TG). Here, we found that treating mice with apoB antisense oligonucleotides (ASOs) for 6 weeks decreased VLDL secretion and plasma cholesterol without causing steatosis. The absence of steatosis was linked to an increase in ER stress in the first 3 weeks of ASO treatment, followed by development of ER autophagy at the end of 6 weeks of treatment...
October 3, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27592475/effect-of-hormonal-contraceptives-on-serum-lipids-a-prospective-study
#20
Huma Dilshad, Rabia Ismail, Safila Naveed, Khan Usmanghani, M Tanweer Alam, Ghulam Sarwar
To estimate the effects of using hormonal contraceptives on serum lipoprotein levels. Lipid profile was measured at baseline and afterward at 3, 6, 9 and 12 months. 1391 Pakistani females taking COCs, DMPA, or non hormonal (NH) contraceptives. The results were calculated by repeated measure ANOVA subsequent to tukey's post hoc test for the multiple comparisons. Statistical examination revealed that differences in lipid profile were significant (p <0.001) among all treated group in comparison with control...
July 2016: Pakistan Journal of Pharmaceutical Sciences
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