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https://www.readbyqxmd.com/read/28539740/evaluation-of-antioxidant-hypolipidemic-and-antiatherogenic-property-of-lycopene-and-astaxanthin-in-atherosclerosis-induced-rats
#1
Rajesh Kumar, Kartik Janardan Salwe, Manimekalai Kumarappan
BACKGROUND: Atherosclerosis is one of the major causes of morbidity and mortality in the world. Antioxidants play a major role in prophylaxis and prevention of progression and complications of atherosclerosis. OBJECTIVE: In this study, we are evaluating the antiatherosclerotic effect of two antioxidants such as astaxanthin and lycopene. MATERIALS AND METHODS: After acclimatization, 24 male SD rats, 8-10 weeks old, 150 ± 10 g, maintained as per CPCSEA guidelines were divided into four groups of six rats each...
April 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28539716/prevention-mechanism-of-2-3-5-4-tetrahydroxy-stilbene-2-o-%C3%AE-d-glucoside-on-lipid-accumulation-in-steatosis-hepatic-l-02-cell
#2
Pei Lin, Jian-Mei Lu, Yan-Fang Wang, Wen Gu, Rong-Hua Zhao, Jie Yu
AIM: 2,3,5,4'-Tetrahydroxy-stilbene-2-O-β-d-glucoside (TSG), a natural stilbene, shows great activities in hepatic lipid regulation, especially for hepatic triglyceride lowering. However, information about its mechanisms on biosynthesis and degradation of triglyceride is still limited. This research pays close attention to clarify the mechanism of TSG on prevention of hepatic lipid accumulation. MATERIALS AND METHODS: TSG was given to steatosis hepatocyte L-02 cell induced by fat emulsion incubation...
April 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28515160/replacement-of-refined-starches-and-added-sugars-with-egg-protein-and-unsaturated-fats-increases-insulin-sensitivity-and-lowers-triglycerides-in-overweight-or-obese-adults-with-elevated-triglycerides
#3
Kevin C Maki, Orsolya M Palacios, Emily Lindner, Kristin M Nieman, Marjorie Bell, Jennifer Sorce
Background: Hypertriglyceridemia is a common condition in the United States and is often associated with other metabolic disturbances, including insulin resistance, metabolic syndrome, and a predominance of small dense LDL particles.Objective: The objective of this trial was to evaluate the effects of a combination of egg protein (Epro) and unsaturated fatty acids (UFAs) substituted for refined starches and added sugars on insulin sensitivity (primary outcome) and other cardiometabolic health markers in overweight or obese adults with elevated triglyceride (TG) concentrations...
May 17, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28504609/age-and-sex-differences-in-serum-adiponectin-and-its-association-with-lipoprotein-fractions
#4
Yoshiharu Tomono, Chika Hiraishi, Hiroshi Yoshida
Objective The correlation of adiponectin with cholesterol concentration of fractionated lipoproteins has not been well investigated. Methods This study included 174 subjects (79 men and 95 women) without diabetes. The medical record data were investigated retrospectively. The study subjects with adiponectin <8.3, > 8.3 but less 13.9, and ≥ 13.9 were classified into tertile groups: Groups A ( n = 59), B ( n = 58) and C ( n = 57), respectively. Results In women, age and HDL-C were higher in Group C than in Groups A and B, but BMI, TG, IDL-C and VLDL-C were lower in Group C than in Groups A and B...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28500244/tamoxifen-reduces-hepatic-vldl-production-and-gh-secretion-in-women-a-possible-mechanism-for-steatosis-development
#5
Vita Birzniece, P Hugh R Barrett, Ken K Y Ho
CONTEXT: Growth hormone (GH) stimulates hepatic synthesis of very-low-density lipoproteins (VLDL), whereas hepatic steatosis develops as a result of GH deficiency. Steatosis is also a complication of tamoxifen treatment, the cause of which is not known. As tamoxifen inhibits the secretion and action of GH, we hypothesize that it induces steatosis by inhibiting hepatic VLDL export. AIM: To investigate whether tamoxifen reduces hepatic VLDL secretion. DESIGN: Eight healthy, normolipidemic women (age 64...
May 12, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28473603/increased-hepatic-mitochondrial-fa-oxidation-leads-to-lower-tg-levels-in-rat-liver-and-plasma-and-is-associated-with-upregulation-of-uncoupling-proteins-and-downregulation-of-apolipoprotein-c-iii
#6
Carine Lindquist, Bodil Bjørndal, Christine Renate Rossmann, Deusdedit Tusubira, Asbjørn Svardal, Gro Vatne Røsland, Karl Johan Tronstad, Seth Hallström, Rolf Kristian Berge
Hepatic mitochondrial function, APOC-III and LPL are potential targets for TG lowering drugs. After three weeks of dietary treatment with the compound 2-(tridec-12 -yn-1-ylthio) acetic acid (1-triple TTA), the hepatic mitochondrial FA oxidation increased more than 5-fold in male Wistar rats. Gene expression analysis in liver showed significant downregulation of APOC-III, and upregulation of LPL and the VLDL receptor. This led to lower hepatic (53 %) and plasma (73 %) TG levels. Concomitantly liver-specific biomarkers related to mitochondrial biogenesis and function (mitochondrial DNA, citrate synthase activity and cytochrome c and Tfam gene expression) were elevated...
May 4, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28471688/atherogenic-impact-of-lecithin-cholesterol-acyltransferase-and-its-relation-to-cholesterol-esterification-rate-in-hdl-fer-hdl-and-aip-log-tg-hdl-c-biomarkers-the-butterfly-effect
#7
M Dobiášová
The atherogenic impact and functional capacity of LCAT was studied and discussed over a half century. This review aims to clarify the key points that may affect the final decision on whether LCAT is an anti-atherogenic or atherogenic factor. There are three main processes involving the efflux of free cholesterol from peripheral cells, LCAT action in intravascular pool where cholesterol esterification rate is under the control of HDL, LDL and VLDL subpopulations, and finally the destination of newly produced cholesteryl esters either to the catabolism in liver or to a futile cycle with apoB lipoproteins...
May 4, 2017: Physiological Research
https://www.readbyqxmd.com/read/28465372/identification-of-4-aminopyrazolopyrimidine-metabolite-that-may-contribute-to-the-hypolipidemic-effects-of-ly2584702-in-long-evans-diet-induced-obese-rats
#8
Tom Estridge, Asim Dey, Charles Reidy, Xiaohong Yu, Yuke Zhang, Maryalice Hartley, Paul L Milligan, Najia Jin, Mark C Kowala, Jennifer K Leohr, Adrian J Fretland, Thomas E Mabry, Debra Luffer-Atlas, M Jane Luo
LY2584702 is an inhibitor of p70 S6 kinase-1 previously developed for the treatment of cancer. In two phase 1 trials in oncology patients, significant reductions of total cholesterol, low density lipoprotein cholesterol (LDL-C) and triglyceride was observed. In the current study, we sought to understand the potential mechanism of action of this compound in regulation of lipid metabolism. In Long Evans diet induced obese (DIO) rats, oral administration of LY2584702 for 3 to 4 weeks led to robust reduction of LDL-C up to 60%...
May 2, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28455595/crebh-mediates-metabolic-inflammation-to-hepatic-vldl-overproduction-and-hyperlipoproteinemia
#9
Yongyan Song, Miaoyun Zhao, Xiao Cheng, Jing Shen, Rituraj Khound, Kezhong Zhang, Qiaozhu Su
Metabolic inflammation is closely associated with hyperlipidemia and cardiovascular disease. However, the underlying mechanisms are not fully understood. The current study established that cAMP-responsive-element-binding protein H (CREBH), an acute-phase transcription factor, enhances very-low-density lipoprotein (VLDL) assembly and secretion by upregulating apolipoprotein B (apoB) expression and contributes to metabolic inflammation-associated hyperlipoproteinemia induced by TNFα, lipopolysaccharides (LPS), and high-fat diet (HFD) in mice...
April 28, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28454077/comparison-of-ftir-atr-and-raman-spectroscopy-in-determination-of-vldl-triglycerides-in-blood-serum-with-pls-regression
#10
Adam Oleszko, Jadwiga Hartwich, Anna Wójtowicz, Marlena Gąsior-Głogowska, Hubert Huras, Małgorzata Komorowska
Hypertriglyceridemia, related with triglyceride (TG) in plasma above 1.7mmol/L is one of the cardiovascular risk factors. Very low density lipoproteins (VLDL) are the main TG carriers. Despite being time consuming, demanding well-qualified staff and expensive instrumentation, ultracentrifugation technique still remains the gold standard for the VLDL isolation. Therefore faster and simpler method of VLDL-TG determination is needed. Vibrational spectroscopy, including FT-IR and Raman, is widely used technique in lipid and protein research...
April 18, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28450679/the-combination-therapy-of-fenofibrate-and-ezetimibe-improved-lipid-profile-and-vascular-function-compared-with-statins-in-patients-with-type-2-diabetes
#11
Atsushi Shinnakasu, Kiyoaki Yamamoto, Mihoko Kurano, Hiroshi Arimura, Aiko Arimura, Akira Kikuti, Hiroshi Hashiguchi, Takahisa Deguti, Yoshihiko Nishio
AIM: Elevated level of serum triglyceride (TG) is a characteristic of type 2 diabetes. We evaluated the clinical significance of intervention for the serum TG levels in the fasting and postprandial states in patients with type 2 diabetes. METHODS: Fifty patients with type 2 diabetes, treated with statins, were selected and divided into two groups. One group was treated with a combination of fenofibrate and ezetimibe (F/E group) and the other group with statins (statin group) for 12 weeks...
April 27, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28449094/hepatic-tm6sf2-overexpression-affects-cellular-apob-trafficking-plasma-lipid-levels-hepatic-steatosis-and-atherosclerosis
#12
Nicole Ehrhardt, Michael E Doche, Shuang Chen, Hui Z Mao, Meghan T Walsh, Candy Bedoya, Maha Guindi, Weidong Xiong, Joseph Ignatius Irudayam, Jahangir Iqbal, Sebastien Fuchs, Samuel W French, M Mahmood Hussain, Moshe Arditi, Vaithilingaraja Arumugaswami, Miklós Péterfy
The human TM6SF2 gene has been implicated in plasma lipoprotein metabolism, alcoholic and non-alcoholic fatty liver disease and myocardial infarction in multiple genome-wide association studies. To investigate the role of Tm6sf2 in metabolic homeostasis, we generated mice with elevated expression using adeno-associated virus (AAV)-mediated gene delivery. Hepatic overexpression of mouse Tm6sf2 resulted in phenotypes previously observed in Tm6sf2-deficient mice including reduced plasma lipid levels, diminished hepatic TG secretion and increased hepatosteatosis...
April 25, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28442378/antihyperlipidemic-and-antiapoptotic-potential-of-zingerone-on-alcohol-induced-hepatotoxicity-in-experimental-rats
#13
Vijay Mani, Sivaranjani Arivalagan, Aktarul Islam Siddique, Nalini Namasivayam
The ultimate aim of this present study was to investigate the antihyperlipidemic and antiapoptotic potential of zingerone (ZO) on alcohol induced hepatotoxicity in experimental rats. Male albino wistar rats were divided in four groups. Groups 1 and 2 rats received isocaloric glucose and dimethyl sulphoxide (2% DMSO), liver toxicity was induced in groups 3 and 4 by supplementing 30% ethanol post orally for 60 days. In addition, groups 2 and 4 received zingerone (20 mg/kg body weight in 2% DMSO) daily during the final 30 days of the experimental period...
April 22, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28437620/american-association-of-clinical-endocrinologists-and-american-college-of-endocrinology-guidelines-for-management-of-dyslipidemia-and-prevention-of-cardiovascular-disease
#14
Paul S Jellinger, Yehuda Handelsman, Paul D Rosenblit, Zachary T Bloomgarden, Vivian A Fonseca, Alan J Garber, George Grunberger, Chris K Guerin, David S H Bell, Jeffrey I Mechanick, Rachel Pessah-Pollack, Kathleen Wyne, Donald Smith, Eliot A Brinton, Sergio Fazio, Michael Davidson
OBJECTIVE: The development of these guidelines is mandated by the American Association of Clinical Endocrinologists (AACE) Board of Directors and American College of Endocrinology (ACE) Board of Trustees and adheres with published AACE protocols for the standardized production of clinical practice guidelines (CPGs). METHODS: Recommendations are based on diligent reviews of the clinical evidence with transparent incorporation of subjective factors, according to established AACE/ACE guidelines for guidelines protocols...
April 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28421037/lipid-processing-in-the-brain-a-key-regulator-of-systemic-metabolism
#15
REVIEW
Kimberley D Bruce, Andrea Zsombok, Robert H Eckel
Metabolic disorders, particularly aberrations in lipid homeostasis, such as obesity, type 2 diabetes mellitus, and hypertriglyceridemia often manifest together as the metabolic syndrome (MetS). Despite major advances in our understanding of the pathogenesis of these disorders, the prevalence of the MetS continues to rise. It is becoming increasingly apparent that intermediary metabolism within the central nervous system is a major contributor to the regulation of systemic metabolism. In particular, lipid metabolism within the brain is tightly regulated to maintain neuronal structure and function and may signal nutrient status to modulate metabolism in key peripheral tissues such as the liver...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28420354/therapeutic-potentials-of-crataegus-azarolus-var-eu-azarolus-maire-leaves-and-its-isolated-compounds
#16
Eman Abu-Gharbieh, Naglaa Gamil Shehab
BACKGROUND: Hyperglycemia is a complicated condition accompanied with high incidence of infection and dyslipidemia. This study aimed to explore the phyto-constituents of Crataegus azarolus var. eu- azarolus Maire leaves, and to evaluate the therapeutic potentials particularly antimicrobial, antihyperglycemic and antihyperlipidemic of the extract and the isolated compound (3β-O-acetyl ursolic acid). METHODS: Total phenolics and flavonoidal contents were measured by RP-HPLC analysis...
April 18, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28419828/hypoglycemic-and-hypolipidemic-effects-of-a-polysaccharide-from-flower-buds-of-lonicera-japonica-in-streptozotocin-induced-diabetic-rats
#17
Dongying Wang, Xiangmei Zhao, Yulan Liu
Hyperglycemia and dyslipidemia are classic features for diabetes mellitus (DM). In this study, one fraction of the crude polysaccharides extracted from Lonicera japonica flower buds (LJP) were investigated for its hypolipidaemic and hypoglycaemic activities by means of streptozotocin (STZ)-induced diabetic rats. Interestingly, after orally administrated with 800mg/kg body weight (B.W.) LJP for 42 days, the food and water intake and the levels of sugar and insulin in blood for the diabetic rats were drastically decreased, while the contents of liver and skeletal muscle glycogen and the concentrations of hepatic pyruvate kinase and hexokinase were obviously increased (p<0...
April 15, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28416782/assessment-of-atherosclerotic-risk-among-patients-with-epilepsy-on-valproic-acid-lamotrigine-and-carbamazepine-treatment
#18
Nudrat A Zuberi, Mukhtiar Baig, Shazia Bano, Zehra Batool, Saeeda Haider, Tahira Perveen
OBJECTIVE: To compare the long-term effects of carbamazepine (CBZ), valproic acid (VPA), and lamotrigine (LTG) as monotherapy on the markers of vascular risk. METHODS: The present cross-sectional study was carried out at the Department of Neurology, Jinnah Postgraduate Medical Centre (JPMC), Karachi, Pakistan, from 2012 to 2013. We selected 120 adult patients with epilepsy and 40 control subjects. The patients with epilepsy were divided into 3 groups according to the use of antiepileptic drugs (AEDs) (CBZ, n = 40; VPA, n = 40; and LTG, n = 40)...
April 2017: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
https://www.readbyqxmd.com/read/28368310/role-of-the-enterocyte-in-fructose-induced-hypertriglyceridaemia
#19
REVIEW
Simon Steenson, A Margot Umpleby, Julie A Lovegrove, Kim G Jackson, Barbara A Fielding
Dietary fructose has been linked to an increased post-prandial triglyceride (TG) level; which is an established independent risk factor for cardiovascular disease. Although much research has focused on the effects of fructose consumption on liver-derived very-low density lipoprotein (VLDL); emerging evidence also suggests that fructose may raise post-prandial TG levels by affecting the metabolism of enterocytes of the small intestine. Enterocytes have become well recognised for their ability to transiently store lipids following a meal and to thus control post-prandial TG levels according to the rate of chylomicron (CM) lipoprotein synthesis and secretion...
April 1, 2017: Nutrients
https://www.readbyqxmd.com/read/28346471/effect-of-functional-sympathetic-nervous-system-impairment-of-the-liver-and-abdominal-visceral-adipose-tissue-on-circulating-triglyceride-rich-lipoproteins
#20
Michael F La Fountaine, Christopher M Cirnigliaro, Steven C Kirshblum, Cristin McKenna, William A Bauman
BACKGROUND: Interruption of sympathetic innervation to the liver and visceral adipose tissue (VAT) in animal models has been reported to reduce VAT lipolysis and hepatic secretion of very low density lipoprotein (VLDL) and concentrations of triglyceride-rich lipoprotein particles. Whether functional impairment of sympathetic nervous system (SNS) innervation to tissues of the abdominal cavity reduce circulating concentrations of triglyceride (TG) and VLDL particles (VLDL-P) was tested in men with spinal cord injury (SCI)...
2017: PloS One
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