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TG AND VLDL

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https://www.readbyqxmd.com/read/29022212/effect-of-food-on-the-pharmacokinetics-of-saroglitazar-magnesium-a-novel-dual-ppar%C3%AE-%C3%AE-agonist-in-healthy-adult-subjects
#1
Maulik R Patel, Kevinkumar A Kansagra, Devang P Parikh, Deven V Parmar, Hardik B Patel, Mayur M Soni, Uday S Patil, Harilal V Patel, Jaimik A Patel, Swagat S Gujarathi, Krupi V Parmar, Nuggehally R Srinivas
BACKGROUND AND OBJECTIVE: Peroxisome proliferator-activated receptors (PPARs) have recently become a focus of interest for their important roles in glucose and lipid metabolism. In humans, PPARα activation causes a decrease in plasma triglyceride (TG) levels, enhancement of high-density lipoprotein cholesterol (HDL-C) and simultaneous enhancement of very-low-density lipoprotein (VLDL) lipolysis, whereas PPARγ agonists act as insulin sensitizers and improve insulin resistance, which is very useful in patients with type 2 diabetes mellitus (T2DM)...
October 11, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28988596/tnf-%C3%AE-il-10-ratio-an-independent-predictor-for-coronary-artery-disease-in-north-indian-population
#2
Reena Kumari, Sandeep Kumar, M Kaleem Ahmad, Rajeev Singh, Akshayaya Pradhan, Sharad Chandra, Sudhir Kumar
BACKGROUND/AIM: Cytokines are responsible for the modulation of immunological and inflammatory processes and play a significant role in the pathogenesis of coronary artery disease (CAD). Tumor necrosis factor-alpha (TNF-α) are considered as a pro inflammatory and interleukin-10 (IL-10) anti inflammatory have been shown to predict the risk of incident of CAD. Aim of present study is to examine the impact of the TNF-α and Il-10 levels on various components of the CAD. METHODS: Total 580 subjects were recruited in the present study out of which 290 diagnosed CAD subjects (Age 51...
September 22, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28971099/effect-of-theobromine-consumption-on-serum-lipoprotein-profiles-in-apparently-healthy-humans-with-low-hdl-cholesterol-concentrations
#3
Doris M Jacobs, Lotte Smolders, Yuguang Lin, Niels de Roo, Elke A Trautwein, John van Duynhoven, Ronald P Mensink, Jogchum Plat, Velitchka V Mihaleva
Scope: Theobromine is a major active compound in cocoa with allegedly beneficial effect on high-density-lipoprotein-cholesterol (HDL-CH). We have investigated the effect of theobromine (TB) consumption on the concentrations of triglyceride (TG) and cholesterol (CH) in various lipoprotein (LP) subclasses. Methods: In a randomized, double-blind, placebo-controlled, cross-over study, 44 apparently healthy women and men (age: 60 ± 6 years, BMI: 29 ± 3 kg/m(2)) with low baseline HDL-CH concentrations consumed a drink supplemented with 500 mg/d theobromine for 4 weeks...
2017: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/28964326/postprandial-vldl-tg-metabolism-in-type-2-diabetes
#4
Esben Søndergaard, Rakel Fuglsang Johansen, Michael D Jensen, Søren Nielsen
BACKGROUND: Type 2 diabetes is associated with excess postprandial lipemia due to accumulation of chylomicrons and VLDL particles. This is a risk factor for development of cardiovascular disease. However, whether the excess lipemia is associated with an impaired suppression of VLDL-TG secretion and/or reduced clearance into adipose tissue is unknown. OBJECTIVE: We measured the postprandial VLDL-TG secretion, clearance and adipose tissue storage to test the hypothesis that impaired postprandial suppression of VLDL-TG secretion, combined with impaired VLDL-TG storage in adipose tissue, is associated with excess postprandial lipemia...
October 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28951062/talinum-triangulare-whole-wheat-meal-fortified-with-soy-flour-consumed-with-talinum-triangulare-gbure-soup-glycemic-index-and-the-test-human-subjects-lipid-profiles
#5
Sunday Adeola Emaleku, Olusola D Omueti, Godsent Oluwakemi Emaleku
AIM: Cardiovascular diseases (CVDs) and diabetes mellitus (DM) are some of the leading causes of death in the world, and diet has roles in their etiology. This research study therefore investigates the glycemic index (GI) of soy flour fortified whole wheat meal (SFFWWM) consumed with Talinum triangulare (gbure) soup and the effects of the meal on the lipid profiles of the test human subjects. METHODS: The control human subjects and test human subjects were fed D-glucose (DG) and whole wheat meal (WWM) with Talinum triangulare soup respectively on the first day of the experiment, and SFFWWM with the same soup the next day (for test subjects only) after 10-12h overnight fasting...
August 24, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28938514/-2-4-fluorobenzamido-4-methylthiazole-5-carboxylic-acid-a-novel-thiazole-compound-ameliorates-insulin-sensitivity-and-hyperlipidaemia-in-streptozotocin-induced-diabetic-rats-plausible-role-of-inflammatory-and-oxidative-stress-markers
#6
Yam Nath Paudel, Md Rahmat Ali, Mohammad Adil, Sandhya Bawa, Manju Sharma
Emerging evidence suggests that thiazole compounds are of great interest due to their protective effect against DM. Protective effects of thiazole derivatives against hyperglycemia have been demonstrated in earlier in vitro and in vivo studies. Previously, anti-oxidant and free radical scavenging activities of 2-(4-Fluorobenzamido)-4-methylthiazole-5-carboxylicacid, a newly developed thiazole derivative (NDTD), have been well-documented. Current study investigated the pharmacological effect of NDTD on hyperglycaemia, insulin sensitivity, lipid profile, anti-inflammatory and oxidative stress markers in an animal model...
September 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28924542/association-of-the-apolipoprotein-a-i-gene-polymorphisms-with-cardiovascular-disease-risk-factors-and-atherogenic-indices-in-patients-from-assam-northeast-india
#7
K Bora, M S Pathak, P Borah, Md I Hussain, D Das
Cardiovascular disease (CVD) risk factors, and particularly decreased high density lipoprotein cholesterol (HDL-C) dyslipidemia are prevalent in Assam, India. This study was undertaken to investigate whether Apolipoprotein A-I (APOA1) gene polymorphisms (G-75A and C+83T) were associated with i) the risk for decreased HDL-C, and ii) other CVD risk factors, viz. serum lipids, atherogenic indices, obesity, and blood pressure (BP). A total of 649 subjects were screened, from which 200 eligible individuals, classified as case group with decreased HDL-C levels (100 subjects) and control group with normal HDL-C levels (100 subjects) were enrolled and genotyped using polymersase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing...
June 30, 2017: Balkan Journal of Medical Genetics: BJMG
https://www.readbyqxmd.com/read/28917868/anti-hyperlipidemic-and-antioxidant-effects-of-alkali-extractable-mycelia-polysaccharides-by-pleurotus-eryngii-var-tuolensis
#8
Zhenzhen Ren, Juan Li, Nuo Xu, Jianjun Zhang, Xinling Song, Xiuxiu Wang, Zheng Gao, Huijuan Jing, Shangshang Li, Chen Zhang, Min Liu, Huajie Zhao, Le Jia
In this study, we noted that the Al-MPS from Pleurotus eryngii var. tuolensis provoked pharmacological effects on blood lipid profiles and oxidative stress. Animal studies demonstrated that Al-MPS showed potential effects on relieving hyperlipidemia and preventing oxidative stress, reflecting by decreasing the levels of serum enzyme activities (ALP, ALT and AST), restoring the activities of antioxidant enzymes (SOD, GSH-Px, CAT and T-AOC), down-regulating the MDA and LPO contents, as well as remitting the hepatic and cardiac tissues injury, respectively...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28870033/-the-expression-and-clinical-significance-of-proprotein-convertase-subtilisin-kexin-9-in-rheumatoid-arthritis
#9
Q Du, X J Yu, H J Li, S Q Guan, Z Y Zhang, Y F Mei
Objective: To assess the expression and significance of proprotein convertase subtilisin kexin 9 (PCSK9) in patients with rheumatoid arthritis (RA). Methods: Sixty-five RA patients and forty-seven healthy controls were recruited in this study. The body mass index (BMI) and serum total cholesterol(TC), triglyceride(TG), high density lipoprotein(HDL), lipoprotein a, low density lipoprotein(LDL), very low density lipoprotein(VLDL), apolipoprotein A(ApoA), apolipoprotein B(ApoB) and the ratio of LDL-C/HDL-C were tested...
September 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/28866046/formaldehyde-alters-triglyceride-synthesis-and-very-low-density-lipoprotein-secretion-in-a-time-dependent-manner
#10
Jianying Bai, Pan Wang, Yanfei Liu, Yan Zhang, Yaofu Li, Zhen He, Lifang Hou, Ruifeng Liang
Formaldehyde is a common indoor air pollutant that is toxic to the liver. This study aimed to investigate the effects of formaldehyde on triglyceride metabolism in human hepatocellular carcinoma cells (HepG2). Cell viability was detected using a MTT (3-(4,5-dimethylthiazol-2-Yl)-2,5-diphenyltetrazolium bromide) assay. Following treatment with different concentrations of formaldehyde for 24 and 48h, the intra and extra-hepatocellular triglyceride (TG) content was determined using a chemical-enzymatic method; Western blotting was used to detect the levels of fatty acid synthesis and VLDL-related proteins...
August 30, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28851734/cardiac-overexpression-of-perilipin-2-induces-dynamic-steatosis-prevention-by-hormone-sensitive-lipase
#11
Masami Ueno, Jinya Suzuki, Masamichi Hirose, Satsuki Sato, Michiko Imagawa, Yasuo Zenimaru, Sadao Takahashi, Shoichiro Ikuyama, Tsutomu Koizumi, Tadashi Konoshita, Fredric B Kraemer, Tamotsu Ishizuka
Cardiac intracellular lipid accumulation (steatosis) is a pathophysiological phenomenon observed in starvation and diabetes mellitus. Perilipin 2 (PLIN2) is a lipid droplet (LD)-associated protein expressed in non-adipose tissues, including the heart. To explore the pathophysiological function of myocardial PLIN2, we generated transgenic (Tg) mice by cardiac-specific overexpression of PLIN2. Tg hearts showed accumulation of numerous small LDs associated with mitochondrial chains, and high cardiac triacylglycerol (TAG) content (8-fold greater than wild-type (Wt) mice)...
August 29, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28838346/molecular-effects-of-leptin-on-peroxisome-proliferator-activated-receptor-gamma-ppar-%C3%AE-mrna-expression-in-rat-s-adipose-and-liver-tissue
#12
A Abbasi, A A Moghadam, Z Kahrarian, R Abbsavaran, K Yari, E Alizadeh
Leptin is a 16-kDa peptide hormone secreted by adipose tissue that participates in the regulation of energy homeostasis. The aim of this study was to determine the effect of leptin injection on mRNA expression of peroxisome proliferator-activated receptor gamma (PPAR-γ) and comparison of PPAR-γ mRNA expression in rat's adipose and liver tissue. Twenty adult male rats were divided into the following groups: Group 1asa control (n=10) that did not receive any treatment. Group 2as a treatment (n=10) that received leptin (30 µg ⁄ kg BW) intraperitoneally (ip) for two successive days...
August 15, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28826937/tempol-improves-lipid-profile-and-prevents-left-ventricular-hypertrophy-in-ldl-receptor-gene-knockout-ldlr-mice-on-a-high-fat-diet
#13
Igor Cândido Viana Gonçalves, Cláudio Daniel Cerdeira, Eduardo Poletti Camara, José Antônio Dias Garcia, Maísa Ribeiro Pereira Lima Brigagão, Roberta Bessa Veloso Silva, Gérsika Bitencourt Dos Santos
INTRODUCTION AND OBJECTIVE: Dyslipidemia is associated with increased risk of cardiovascular disease and atherosclerosis, and hence with high morbidity and mortality. This study investigated the effects of the nitroxide 4-hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl (Tempol) on lipid profile and cardiac morphology in low-density lipoprotein (LDL) receptor gene knockout (LDLr-/-) mice. METHODS: Male LDLr-/- mice (three months old, approximately 22 g weight) were divided into the following groups: controls, including (1) standard chow (SC, n=8) and (2) high-fat diet (HFD, n=8); and treatment, including (3) standard chow + Tempol (SC+T, n=8) (30 mg/kg administered by gavage, once daily) and (4) high-fat diet + Tempol (HFD+T, n=8) (30 mg/kg)...
August 18, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/28826565/lipoprotein-particle-number-and-size-predict-vascular-structure-and-function-better-than-traditional-lipids-in-adolescents-and-young-adults
#14
Elaine M Urbina, Connie E McCoy, Zhiqian Gao, Philip R Khoury, Amy S Shah, Lawrence M Dolan, Thomas R Kimball
BACKGROUND: In adults, dyslipidemia is associated with higher carotid thickness and arterial stiffness, predictors of cardiovascular events. In young subjects, lipid concentrations have not been consistently associated with vascular measures. OBJECTIVE: The objective of the study was to compare nuclear magnetic resonance (NMR) measures of lipoprotein particle number (low-density lipoprotein [LDL] particle, low-density lipoprotein [HDL] particle, very low-density lipoprotein [VLDL] particle) and size (LDL size, HDL size, and VLDL size) to determine if they were associated with vascular measures more strongly than lipid concentrations (LDL cholesterol, HDL cholesterol, and triglyceride [TG])...
July 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28817948/effects-of-dietary-supplementation-of-resveratrol-on-performance-egg-quality-yolk-cholesterol-and-antioxidant-enzyme-activity-of-laying-hens
#15
Z H Feng, J G Gong, G X Zhao, X Lin, Y C Liu, K W Ma
1. This experiment was conducted to evaluate the effects of dietary supplementation of resveratrol on laying performance, egg quality, egg yolk cholesterol and antioxidant enzyme activities of laying hens. 2. A total of 360 Beijing PINK-1 laying hens (60 weeks old) were randomly distributed among five dietary treatments, each of which included 6 replicates of 12 hens. Dietary treatments were basal diet supplemented with 0 (control), 0.5, 1.0, 2.0 and 4.0 g/kg diet resveratrol. The study lasted for 9 weeks including 1 week of adaptation and 8 weeks of the main experimental period...
September 4, 2017: British Poultry Science
https://www.readbyqxmd.com/read/28817248/attenuated-suppression-of-lipolysis-explains-the-increases-in-triglyceride-secretion-and-concentration-associated-with-basal-insulin-peglispro-relative-to-insulin-glargine-treatment-in-patients-with-type-1-diabetes
#16
Rakel F Johansen, Esben Søndergaard, Helle Linnebjerg, Parag Garhyan, Eric C Q Lam, Niels Porksen, Scott J Jacober, Søren Nielsen
AIMS: To test the hypothesis that, as well as lowering weight and increasing plasma triglyceride (TG) levels and hepatic fat compared with insulin glargine (GL) in patients with type 1 diabetes, the attenuated peripheral effects of basal insulin peglispro (BIL) may include increased free fatty acid flux to the liver, causing increased very-low-density lipoprotein (VLDL)-TG secretion and lipid oxidation, and decreased TG adipose tissue deposition. METHODS: In this open-label, randomized, 2-period crossover study, 14 patients with type 1 diabetes received once-daily, individualized, stable BIL or GL doses for 3 weeks...
August 17, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28804115/relevance-of-serum-concentrations-of-non-esterified-fatty-acids-and-very-low-density-lipoproteins-in-nulli-primiparous-and-multiparous-cows-in-the-close-up-period
#17
Shin Oikawa, Haruka Saitoh-Okumura, Masaki Tanji, Ken Nakada
Serum concentrations of non-esterified fatty acids (NEFA) and very low-density lipoprotein (VLDL) in close-up dairy cattle were compared in relation to parity. Data were obtained from 37 nulli/primiparous (NP) and 24 multiparous (MU, parity: 2-7) cows between 14 days and 1 day prepartum. A positive correlation (r=0.684, P<0.01) was found between serum NEFA and VLDL concentrations in NP cows. Among the VLDL constituents, the NEFA concentration was particularly correlated with the triglyceride (TG) concentration (r=0...
August 13, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28797569/the-impact-of-multiple-blood-donations-on-the-risk-of-cardiovascular-diseases-insight-of-lipid-profile
#18
M A Bani-Ahmad, O F Khabour, M Y Gharibeh, K N Alshlool
OBJECTIVES: The reduction in blood viscosity and iron store were proposed to be connected to the reduction in the risk of cardiovascular disease (CVD) among multiple blood donors. Herein, we evaluated the modulation of serum lipids levels in accordance with donation events. Furthermore, atherogenic impacts on the risk of CVD were investigated. MATERIALS AND METHODS: A total of 100 voluntarily male donors were included in the study. Fifty donors were multiple time donors (MTD) and 50 were single time donors (STD)...
August 7, 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/28797250/omega-3-fatty-acids-eicosapentaenoic-acid-and-docosahexaenoic-acid-and-their-mechanisms-of-action-on-apolipoprotein-b-containing-lipoproteins-in-humans-a-review
#19
REVIEW
Jan Oscarsson, Eva Hurt-Camejo
BACKGROUND: Epidemiological and genetic studies suggest that elevated triglyceride (TG)-rich lipoprotein levels in the circulation increase the risk of cardiovascular disease. Prescription formulations of omega-3 fatty acids (OM3FAs), mainly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), reduce plasma TG levels and are approved for the treatment of patients with severe hypertriglyceridemia. Many preclinical studies have investigated the TG-lowering mechanisms of action of OM3FAs, but less is known from clinical studies...
August 10, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28792970/targeting-hepatic-heparin-binding-egf-like-growth-factor-hb-egf-induces-anti-hyperlipidemia-leading-to-reduction-of-angiotensin-ii-induced-aneurysm-development
#20
Seonwook Kim, Lihua Yang, Seongu Kim, Richard G Lee, Mark J Graham, Judith A Berliner, Aldons J Lusis, Lei Cai, Ryan E Temel, Debra L Rateri, Sangderk Lee
OBJECTIVE: The upregulated expression of heparin binding EGF-like growth factor (HB-EGF) in the vessel and circulation is associated with risk of cardiovascular disease. In this study, we tested the effects of HB-EGF targeting using HB-EGF-specific antisense oligonucleotide (ASO) on the development of aortic aneurysm in a mouse aneurysm model. APPROACH AND RESULTS: Low-density lipoprotein receptor (LDLR) deficient mice (male, 16 weeks of age) were injected with control and HB-EGF ASOs for 10 weeks...
2017: PloS One
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