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https://www.readbyqxmd.com/read/29453968/lipoprotein-lipase-biosynthesis-regulatory-factors-and-its-role-in-atherosclerosis-and-other-diseases
#1
REVIEW
Ping-Ping He, Ting Jiang, Xin-Ping OuYang, Ya-Qin Liang, Jie-Qiong Zou, Yan Wang, Qian-Qian Shen, Li Liao, Xi-Long Zheng
Lipoprotein lipase (LPL) is a rate-limiting enzyme that catalyzes hydrolysis of the triglyceride (TG) core of circulating TG-rich lipoproteins including chylomicrons (CM), low-density lipoproteins (LDL) and very low-density lipoproteins (VLDL). A variety of parenchymal cells can synthesize and secrete LPL. Recent studies have demonstrated that complicated processes are involved in LPL biosynthesis, secretion and transport. The enzyme activity of LPL is regulated by many factors, such as apolipoproteins, angiopoietins, hormones and miRNAs...
February 14, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29438776/quercetin-ameliorates-hfd-induced-nafld-by-promoting-hepatic-vldl-assembly-and-lipophagy-via-the-ire1a-xbp1s-pathway
#2
Xinhong Zhu, Ting Xiong, Peiyi Liu, Xiaoping Guo, Lin Xiao, Feng Zhou, Yuhan Tang, Ping Yao
The consumption of a quercetin-rich diet has been well-established as a feasible method against non-alcoholic fatty liver disease (NAFLD); however, the molecular mechanisms underlying the progression of NAFLD and its intervention by quercetin remain largely obscure. Male Sprague-Dawley rats fed high-fat diet (HFD), and HepG2 cells stimulated with free fatty acid, were treated with quercetin and various pharmacological reagents to explore the effect of signaling pathways involved in endoplasmic reticulum stress on very low-density lipoprotein (VLDL) assembly and lipophagy...
February 10, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29438437/a-novel-lpl-intronic-variant-g-18704c-a-identified-by-re-sequencing-kuwaiti-arab-samples-is-associated-with-high-density-lipoprotein-very-low-density-lipoprotein-and-triglyceride-lipid-levels
#3
Suzanne A Al-Bustan, Ahmad Al-Serri, Babitha G Annice, Majed A Alnaqeeb, Wafa Y Al-Kandari, Mohammed Dashti
The role interethnic genetic differences play in plasma lipid level variation across populations is a global health concern. Several genes involved in lipid metabolism and transport are strong candidates for the genetic association with lipid level variation especially lipoprotein lipase (LPL). The objective of this study was to re-sequence the full LPL gene in Kuwaiti Arabs, analyse the sequence variation and identify variants that could attribute to variation in plasma lipid levels for further genetic association...
2018: PloS One
https://www.readbyqxmd.com/read/29405635/metformin-does-not-affect-postabsorptive-hepatic-free-fatty-acid-uptake-oxidation-or-resecretion-in-humans-a-3-months-placebo-controlled-clinical-trial-in-patients-with-type-2-diabetes-and-healthy-controls
#4
Lars C Gormsen, Esben Søndergaard, Nana L Christensen, Steen Jakobsen, Erik H T Nielsen, Ole L Munk, Lars P Tolbod, Niels Jessen, Søren Nielsen
AIMS: Metformin is due to its well-documented glucose lowering effect the most commonly used drug in patients with T2D. However, metformin have also in pre-clinical studies been shown to improve lipid metabolism, possibly through modulation of intrahepatic partitioning of fatty acids towards oxidation and away from reesterification and resecretion as triglycerides. MATERIALS AND METHODS: To explore whether these pre-clinical findings can be translated to a human setting, we performed a 3-month randomized, placebo controlled, parallel-group clinical trial in patients with T2D (24 patients) and healthy controls (12 subjects)...
February 6, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29387371/antihyperglycemic-and-antidyslipidemic-activity-of-musa-paradisiaca-based-diet-in-alloxan-induced-diabetic-rats
#5
Basiru O Ajiboye, Hussein O B Oloyede, Musa O Salawu
This study was aimed at investigating the antihyperglycemic and antidyslipidemic activity of Musa paradisiaca-based diets in alloxan-induced diabetic mellitus rats. Diabetes was induced by a single intraperitoneal injection of alloxan (150 mg/kg b.w) in 48 randomly selected rats. The rats were randomly grouped into four as follows: normal rats fed Dioscorea rotundata-based diet, diabetic control rats fed D. rotundata-based diet, diabetic rats fed D. rotundata-based diet and administered metformin (14.2 mg/kg body weight) orally per day, and diabetic rats fed M...
January 2018: Food Science & Nutrition
https://www.readbyqxmd.com/read/29382504/balanced-high-fat-diet-reduces-cardiovascular-risk-in-obese-women-although-changes-in-adipose-tissue-lipoproteins-and-insulin-resistance-differ-by-race
#6
K D Niswender, S Fazio, B A Gower, H J Silver
BACKGROUND: We previously reported that consuming a balanced high fat diet (BHFD) wherein total saturated fat was reduced and total unsaturated fat increased by proportionately balancing the type of fat (1/3 saturated, 1/3 monounsaturated, 1/3 polyunsaturated) led to significant improvements in inflammatory burden, blood pressure, and vascular function in obese premenopausal European American (EA) and African American (AA) women. OBJECTIVE: Here we compared changes in adipose tissue, lipoproteins, insulin resistance, and cardiovascular risk between EA and AA women...
January 27, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29369816/beneficial-effect-of-ghee-consumption-over-mustard-oil-on-lipid-profile-a-study-in-north-indian-adult-population
#7
Hanjabam Barun Sharma, Soniya Vyas, Jayant Kumar, Soumen Manna
Background Ghee (G) is attributed with numerous health benefits in Ayurveda. However, due to the high saturated fat content, it has been predicted to increase the cardiovascular disease risk. Hence, the current study was performed to evaluate the effect of G consumption as compared to mustard oil (MO) on lipid profile. Methods Two hundred (100 males) apparently healthy adults (≥40 years) were randomly selected out of the total individuals interviewed in a house-to-house survey. They were divided into three groups based on G and MO consumption: (A) MO >1 L/month, G<0...
January 24, 2018: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29351922/activation-of-constitutive-androstane-receptor-ameliorates-renal-ischemia-reperfusion-induced-liver-and-kidney-injury
#8
You-Jin Choi, Dong Zhou, Anne Barbosa, Yongdong Niu, Xiudong Guan, Meishu Xu, Songrong Ren, Thomas Nolin, Yiuhua Liu, Wen Xie
Acute kidney injury (AKI) is associate with high mortality. Despite the evidence of AKI-induced distant organ injury, a relationship between AKI and liver injury has not been clearly established. The goal of this study is to investigate whether renal ischemia-reperfusion (IR) can affect liver pathophysiology. We showed that renal IR in mice induced fatty liver and compromised liver function through the down-regulation of constitutive androstane receptor (CAR; -90.4%) and inhibition of hepatic very low-density lipoprotein-triglyceride (VLDL-TG) secretion (-28...
January 19, 2018: Molecular Pharmacology
https://www.readbyqxmd.com/read/29338972/hdl-c-apoa1-and-vldl-tg-as-biomarkers-for-the-carotid-plaque-presence-in-patients-with-metabolic-syndrome
#9
Meryem Abi-Ayad, Amine Abbou, Fatima Zahra Abi-Ayad, Omar Behadada, Mohamed Benyoucef
AIM: Hypercholesterolemia and hyper LDL-C are associated with the atherosclerosis (AS). The current study was performed to evaluate the implication of the others lipoproteins (HDL, LDL, VLDL) and apolipoproteins (ApoA1, ApoB100) with subclinical atherosclerosis (carotid plaque) in patients with metabolic syndrome (MetS) free from cardiovascular disease (CVD). METHODS: Prospective transversal study was conducted in patients with MetS free from cardiovascular disease (CVD)...
December 30, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29306619/comparative-study-between-conventional-fasting-versus-overnight-infusion-of-lipid-or-carbohydrate-on-insulin-and-free-fatty-acids-in-obese-patients-undergoing-elective-on-pump-coronary-artery-bypass-grafting-a-prospective-randomized-trial
#10
Hisham Hosny, Mohamed Ibrahim, Wael El-Siory, Amr Abdel-Monem
OBJECTIVES: Postoperative insulin resistance represents a major component of postoperative metabolic disorder. The authors compared the effects of preoperative infusion of lipid emulsion or carbohydrate to conventional preoperative fasting on postoperative insulin and free fatty acid (FFA) levels. DESIGN: A prospective randomized double-blinded study. SETTINGS: Tertiary university hospital. PARTICIPANTS: Sixty-three patients undergoing coronary artery bypass grafting...
November 24, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29247727/comparative-investigation-for-hypoglycemic-effects-of-polysaccharides-from-four-substitutes-of-lonicera-japonica-in-chinese-medicine
#11
Xiangmei Zhao, Dongying Wang, Lijie Qin, Xianzhi Yang, Chuanyu Gao
The polysaccharide fractions were obtained from flower buds of the four substitutes of Lonicera japonica, L. macranthoides (LMPB), L. hypoglauca (LHPB), L. fulvotomentosa (LFPB) and L. confuse (LCPB), and their hypoglycemic effects were investigated. In study, streptozocin (STZ)-induced diabetic rats were orally administrated once daily with LMPB, LHPB, LFPB and LCPB (each 800 mg/kg) for 42 days. Reduction for food and water intake (p < 0.05, p < 0.01) and levels of sugar and insulin (p < 0...
December 13, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29207826/the-association-between-periodontal-status-serum-lipid-levels-lipoprotein-associated-phosholipase-a2-lp-pla2-in-chronic-periodontitis-subjects-and-healthy-controls
#12
Bittu Saira Koshy, Jaideep Mahendra
Introduction: Lipoprotein associated phospholipase A2 (Lp-PLA2) has been explored as a potential biomarker for Cardiovascular Disease (CVD). The human Lp-PLA2 is a serine-dependent, Ca2+- independent enzyme. It gives way to oxidised free fatty acids and lysophosphatidyl choline by hydrolysing oxidised phospholipids, that leads to smooth muscle cell apoptosis, inflammatory cell chemotaxis and endothelial cell dysfunction in CVD. Owing to its role in inflammation, it may influence the development and progression of periodontitis as well...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29202484/usefulness-of-martin-s-method-for-estimation-of-low-density-lipoprotein-cholesterol-in-coronary-atherosclerosis
#13
Soie Chung
OBJECTIVE: This study was conducted to validate Martin's method in coronary atherosclerosis in comparison with Friedewald's equation. SUBJECTS AND METHODS: A total of 299 participants with a coronary artery calcium score (CACS) ≥ 300 and a serum triglyceride (TG) level < 400 mg/dL at Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea were enrolled in this study. The Low-density lipoprotein cholesterol (LDL-C) was directly measured with a homogeneous assay (DLDL) and estimated by both Friedewald's equation (FLDL) and Martin's method (MLDL)...
December 4, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29193277/spectrophotometry-and-ultracentrifugation-for-measurement-of-plasma-lipids-in-dogs-with-diabetes-mellitus
#14
E C Seage, K J Drobatz, R S Hess
BACKGROUND: There are conflicting reports of plasma lipoprotein lipid content in dogs with diabetes mellitus (DM). OBJECTIVES: To determine lipoprotein lipid content of plasma of dogs with DM by spectrophotometry and ultracentrifugation; to compare lipoprotein lipid content in diabetic and healthy dogs; and to quantify apolipoprotein B-100 (ApoB) in dogs with DM. ANIMALS: 22 dogs with DM and 9 healthy dogs. METHODS: Cross-sectional study...
November 29, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29183623/role-of-angiopoietin-like-3-angptl3-in-regulating-plasma-level-of-low-density-lipoprotein-cholesterol
#15
Yu-Xin Xu, Valeska Redon, Haojie Yu, William Querbes, James Pirruccello, Abigail Liebow, Amy Deik, Kevin Trindade, Xiao Wang, Kiran Musunuru, Clary B Clish, Chad Cowan, Kevin Fizgerald, Daniel Rader, Sekar Kathiresan
BACKGROUND AND AIMS: Angiopoietin-like 3 (ANGPTL3) has emerged as a key regulator of lipoprotein metabolism in humans. Homozygous loss of ANGPTL3 function causes familial combined hypolipidemia characterized by low plasma levels of triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). While known effects of ANGPTL3 in inhibiting lipoprotein lipase and endothelial lipase contribute to the low TG and HDL-C, respectively, the basis of low LDL-C remains unclear...
September 21, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29181401/investigation-into-hypoglycemic-antihyperlipidemic-and-renoprotective-potentials-of-dennettia-tripetala-pepper-fruit-seed-in-a-rat-model-of-diabetes
#16
Innocent Anioke, Chukwugozie Okwuosa, Ikenna Uchendu, Olive Chijioke, Ogechukwu Dozie-Nwakile, Ifeoma Ikegwuonu, Peculiar Kalu, Maryann Okafor
This study investigated the hypoglycemic, antihyperlipidemic, and renoprotective potentials of Dennettia tripetala (DT) in a rat model of diabetes. The hypoglycemic activity in crude methanol seed extract of DT (CMEDT) and methanol seed fraction of DT (MFDT) measured by glucose oxidase method was increased by 47.37% and 28.72%, respectively, after 8 hours of administration. After 10 days of treatment, CMEDT and MFDT gave a good glycemic control with the highest percentage reduction of 75.82% and 71.34% in glucose level, respectively, which is closely compared with 79...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29135689/vldl-triglyceride-accumulation-in-skeletal-muscle-and-adipose-tissue-in-type-2-diabetes
#17
Esben Søndergaard, Søren Nielsen
PURPOSE OF REVIEW: Insulin resistance is closely linked to accumulation of lipid outside adipose tissue (ectopic fat storage). VLDL particles transport lipids from the liver to peripheral tissues. However, whether abnormalities in VLDL-triglyceride storage in muscle and adipose tissue exist in type 2 diabetes has previously been unknown, primarily because of methodological difficulties. Here, we review recent research on VLDL-triglyceride storage. RECENT FINDINGS: In a recent study, men with type 2 diabetes had increased skeletal muscle VLDL-triglyceride storage compared to weight-matched nondiabetic men, potentially leading to intramyocellular triglyceride accumulation...
November 11, 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/29132372/hepatitis-b-virus-inhibits-the-in-vivo-and-in-vitro-synthesis-and-secretion-of-apolipoprotein-c3
#18
Chengliang Zhu, Hengcheng Zhu, Hui Song, Limin Xu, Longxuan Li, Fang Liu, Xinghui Liu
BACKGROUND: Hepatitis B virus (HBV) infection in the body can damage liver cells and cause disorders in blood lipid metabolism. Apolipoprotein C3 (ApoC3) plays an important role in the regulation of lipid metabolism, but no study on the HBV regulation of ApoC3 has been reported. This purpose of this study was to investigate the effect of HBV on ApoC3 expression and its regulatory mechanism. METHODS: The expression levels of ApoC3 mRNA and protein in the human hepatoma cell lines HepG2 and HepG2...
November 13, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29124482/apociii-as-a-cardiovascular-risk-factor-and-modulation-by-the-novel-lipid-lowering-agent-volanesorsen
#19
REVIEW
Natalia A Rocha, Cara East, Jun Zhang, Peter A McCullough
PURPOSE OF REVIEW: Apolipoprotein CIII (ApoCIII) is now recognized as a key regulator in severe hypertriglyceridemia, chylomicronemia, and conditions of triglyceride-rich lipoprotein (TRL) remnant excess due to its inhibition of lipoprotein lipase (LPL) and hepatic lipase, leading to decreased hepatic reuptake of TRLs, as well as enhanced synthesis and secretion of VLDL from the liver. ApoCIII gain-of-function mutations are associated with atherosclerosis and coronary heart disease (CHD), and contribute to the development of cardiometabolic syndrome, hypertriglyceridemia, and type 2 diabetes mellitus...
November 9, 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29100061/apolipoprotein-c-ii-new-findings-related-to-genetics-biochemistry-and-role-in-triglyceride-metabolism
#20
REVIEW
Anna Wolska, Richard L Dunbar, Lita A Freeman, Masako Ueda, Marcelo J Amar, Denis O Sviridov, Alan T Remaley
Apolipoprotein C-II (apoC-II) is a small exchangeable apolipoprotein found on triglyceride-rich lipoproteins (TRL), such as chylomicrons (CM) and very low-density lipoproteins (VLDL), and on high-density lipoproteins (HDL), particularly during fasting. ApoC-II plays a critical role in TRL metabolism by acting as a cofactor of lipoprotein lipase (LPL), the main enzyme that hydrolyses plasma triglycerides (TG) on TRL. Here, we present an overview of the role of apoC-II in TG metabolism, emphasizing recent novel findings regarding its transcriptional regulation and biochemistry...
October 20, 2017: Atherosclerosis
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